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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:crotonaldehyde
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Accession:CHEBI:41607 term browser browse the term
Definition:An enal consisting of propene having a formyl group at the 1-position.
Synonyms:related_synonym: (2E)-BUT-2-ENAL;   (E)-crotonaldehyde;   1-formylpropene;   2-Butenal;   Formula=C4H6O;   InChI=1S/C4H6O/c1-2-3-4-5/h2-4H,1H3/b3-2+;   InChIKey=MLUCVPSAIODCQM-NSCUHMNNSA-N;   SMILES=[H]C(=O)\\C=C\\C;   aldehyde crotonique;   beta-methylacrolein;   crotonal;   crotonic aldehyde;   crotylaldehyde;   methylpropenal;   propylene aldehyde;   trans-2-butenal;   trans-2-butenaldehyde;   trans-but-2-enal;   trans-crotonaldehyde
 xref: CAS:123-73-9;   CAS:4170-30-3;   KEGG:C19377
 xref_mesh: MESH:C012796
 xref: PDBeChem:CRD;   PMID:20153411;   PMID:20672270;   PMID:20736172;   PMID:21238556;   PMID:21306579;   Reaxys:1209254



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crotonaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 decreases expression ISO 2-butenal results in decreased expression of ABCC5 mRNA CTD PMID:20471460 NCBI chr11:93,975,579...94,071,659 JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide affects reduction EXP ADH1 protein affects the reduction of 2-butenal CTD PMID:12604195 NCBI chr 2:226,797,303...226,808,892 JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression ISO 2-butenal results in decreased expression of ADRB2 mRNA CTD PMID:20471460 NCBI chr18:57,912,760...57,914,802 JBrowse link
G Agt angiotensinogen increases expression EXP 2-butenal results in increased expression of AGT protein CTD PMID:30426860 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Akap11 A-kinase anchoring protein 11 decreases expression ISO 2-butenal results in decreased expression of AKAP11 mRNA CTD PMID:20471460 NCBI chr15:53,911,635...53,956,138 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 affects reduction EXP AKR1A1 protein affects the reduction of 2-butenal CTD PMID:12604195 NCBI chr 5:135,329,605...135,367,037 JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of 2-butenal; AKR1B1 protein results in increased reduction of 2-butenal metabolite CTD PMID:9890881 PMID:21329684 NCBI chr 4:63,899,222...63,913,315 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects metabolic processing
increases reduction
decreases response to substance
ISO 2-butenal affects the metabolism of AKR1B10 protein
AKR1B10 protein results in increased reduction of 2-butenal; AKR1B10 protein results in increased reduction of 2-butenal metabolite
AKR1B10 protein results in decreased susceptibility to 2-butenal
CTD PMID:17597105 PMID:21329684 NCBI chr 4:64,005,632...64,027,860 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO 2-butenal results in increased expression of AKR1C1 mRNA CTD PMID:20471460 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO 2-butenal results in increased expression of AKR1C3 mRNA CTD PMID:20471460 NCBI chr17:71,020,884...71,037,779 JBrowse link
G Alb albumin increases secretion ISO 2-butenal results in increased secretion of ALB protein CTD PMID:32634517 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO 2-butenal results in increased expression of ALDH1A3 mRNA CTD PMID:20471460 NCBI chr 1:119,982,272...120,017,416 JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 affects oxidation EXP ALDH3A2 protein affects the oxidation of 2-butenal CTD PMID:12604195 NCBI chr10:46,427,789...46,448,449 JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO 2-butenal results in decreased expression of ANGPTL4 mRNA CTD PMID:20471460 NCBI chr 7:14,550,288...14,557,797 JBrowse link
G Ankfy1 ankyrin repeat and FYVE domain containing 1 decreases expression ISO 2-butenal results in decreased expression of ANKFY1 mRNA CTD PMID:20471460 NCBI chr10:57,312,246...57,383,964 JBrowse link
G Ankrd10 ankyrin repeat domain 10 decreases expression ISO 2-butenal results in decreased expression of ANKRD10 mRNA CTD PMID:20471460 NCBI chr16:77,866,489...77,889,745 JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 2-butenal results in increased expression of ANKRD37 mRNA CTD PMID:20471460 NCBI chr16:53,001,487...53,004,545 JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression ISO 2-butenal results in decreased expression of ARHGAP11A mRNA CTD PMID:20471460 NCBI chr 3:100,590,865...100,607,146 JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO 2-butenal results in decreased expression of ARMC8 mRNA CTD PMID:20471460 NCBI chr 8:108,916,274...109,010,877 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 2-butenal results in increased expression of ATF3 mRNA CTD PMID:20471460 NCBI chr13:105,274,103...105,331,653 JBrowse link
G B2m beta-2 microglobulin increases expression EXP 2-butenal results in increased expression of B2M protein CTD PMID:30426860 NCBI chr 3:129,549,236...129,555,354 JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO 2-butenal results in increased expression of BAG3 mRNA CTD PMID:20471460 NCBI chr 1:192,533,460...192,557,281 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2-butenal results in increased expression of BAX protein CTD PMID:31345100 PMID:33749501 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP 2-butenal results in decreased expression of BCL2 protein CTD PMID:31345100 PMID:33749501 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [2-butenal co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BIRC3 mRNA CTD PMID:24849683 NCBI chr 8:13,285,702...13,313,329 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 decreases expression ISO 2-butenal results in decreased expression of BMPR2 mRNA CTD PMID:20471460 NCBI chr 9:68,685,942...68,801,353 JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO 2-butenal results in decreased expression of BPTF mRNA CTD PMID:20471460 NCBI chr10:92,480,007...92,582,485 JBrowse link
G Casp3 caspase 3 increases activity
affects expression
increases expression
EXP 2-butenal results in increased activity of CASP3 protein
2-butenal affects the expression of CASP3 protein
2-butenal results in increased expression of CASP3 protein
CTD PMID:23535401 PMID:31345100 PMID:33749501 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp7 caspase 7 increases activity EXP 2-butenal results in increased activity of CASP7 protein CTD PMID:23535401 NCBI chr 1:265,442,647...265,481,938 JBrowse link
G Casp9 caspase 9 increases activity
affects expression
increases expression
EXP 2-butenal results in increased activity of CASP9 protein
2-butenal affects the expression of CASP9 protein
2-butenal results in increased expression of CASP9 protein
CTD PMID:23535401 PMID:31345100 PMID:33749501
G Cat catalase decreases activity EXP 2-butenal results in decreased activity of CAT protein CTD PMID:30426860 PMID:31345100 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccdc121 coiled-coil domain containing 121 increases expression ISO 2-butenal results in increased expression of CCDC121 mRNA CTD PMID:20471460 NCBI chr 6:24,970,845...24,973,451 JBrowse link
G Ccdc9b coiled-coil domain containing 9B decreases expression ISO 2-butenal results in decreased expression of CCDC9B mRNA CTD PMID:20471460 NCBI chr 3:105,736,120...105,745,039 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 2-butenal results in decreased expression of CCL2 mRNA CTD PMID:20471460 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO 2-butenal results in increased expression of CCL25 mRNA CTD PMID:20471460 NCBI chr12:2,707,398...2,716,571 JBrowse link
G Ccl26 C-C motif chemokine ligand 26 increases expression ISO 2-butenal results in increased expression of CCL26 mRNA CTD PMID:20471460 NCBI chr12:26,745,972...26,750,924 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 2-butenal results in decreased expression of CCND1 mRNA CTD PMID:20471460 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO 2-butenal results in increased expression of CHAC1 mRNA CTD PMID:20471460 NCBI chr 3:126,796,131...126,799,352 JBrowse link
G Chmp1b charged multivesicular body protein 1B increases expression ISO 2-butenal results in increased expression of CHMP1B mRNA CTD PMID:20471460 NCBI chr18:60,740,349...60,742,879 JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO 2-butenal results in increased expression of CLK1 mRNA CTD PMID:20471460 NCBI chr 9:67,441,962...67,453,180 JBrowse link
G Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 decreases expression ISO 2-butenal results in decreased expression of CMTM7 mRNA CTD PMID:20471460 NCBI chr 8:114,448,037...114,474,958 JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO 2-butenal results in increased expression of CREBRF mRNA CTD PMID:20471460 NCBI chr10:16,903,607...16,967,450 JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO 2-butenal results in decreased expression of CSF1 mRNA CTD PMID:20471460 NCBI chr 2:198,065,400...198,084,774 JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
decreases secretion
ISO 2-butenal results in decreased expression of CSF2 mRNA
2-butenal results in decreased secretion of CSF2 protein
CTD PMID:17491020 PMID:20471460 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO 2-butenal results in decreased expression of CSF3 mRNA CTD PMID:20471460 NCBI chr10:84,157,485...84,159,860 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO 2-butenal results in decreased expression of CXCL1 mRNA CTD PMID:20471460 NCBI chr14:17,477,542...17,479,321 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO 2-butenal results in decreased expression of CXCL2 mRNA CTD PMID:20471460 NCBI chr14:17,465,210...17,467,255 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO 2-butenal results in decreased expression of CXCL1 mRNA CTD PMID:20471460 NCBI chr14:17,571,900...17,573,624 JBrowse link
G Cycs cytochrome c, somatic increases expression EXP 2-butenal results in increased expression of CYCS protein CTD PMID:31345100 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 decreases expression ISO 2-butenal results in decreased expression of DBT mRNA CTD PMID:20471460 NCBI chr 2:204,481,744...204,510,612 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 2-butenal results in increased expression of DDIT3 mRNA CTD PMID:20471460 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Dedd2 death effector domain containing 2 increases expression ISO 2-butenal results in increased expression of DEDD2 mRNA CTD PMID:20471460 NCBI chr 1:80,789,084...80,807,789 JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO 2-butenal results in increased expression of DNAJB1 mRNA CTD PMID:20471460 NCBI chr19:41,427,453...41,431,141 JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 2-butenal results in increased expression of DNAJB4 mRNA CTD PMID:20471460 NCBI chr 2:243,790,296...243,819,042 JBrowse link
G Dok3 docking protein 3 decreases expression ISO 2-butenal results in decreased expression of DOK3 mRNA CTD PMID:20471460 NCBI chr17:9,109,633...9,115,188 JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 2-butenal results in increased expression of DUSP10 mRNA CTD PMID:20471460 NCBI chr13:98,145,317...98,183,304 JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO 2-butenal results in decreased expression of E2F8 mRNA CTD PMID:20471460 NCBI chr 1:107,701,985...107,720,538 JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 increases expression ISO 2-butenal results in increased expression of EID3 mRNA CTD PMID:20471460 NCBI chr 7:20,860,073...20,861,395 JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases expression ISO 2-butenal results in decreased expression of ELAVL1 mRNA CTD PMID:20471460 NCBI chr12:2,640,936...2,684,787 JBrowse link
G Elk4 ETS transcription factor ELK4 decreases expression ISO 2-butenal results in decreased expression of ELK4 mRNA CTD PMID:20471460 NCBI chr13:43,451,130...43,475,035 JBrowse link
G Fam217b family with sequence similarity 217, member B decreases expression ISO 2-butenal results in decreased expression of FAM217B mRNA CTD PMID:20471460 NCBI chr 3:185,883,277...185,892,976 JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO 2-butenal results in decreased expression of FBXO5 mRNA CTD PMID:20471460 NCBI chr 1:44,601,412...44,607,781 JBrowse link
G Fgd4 FYVE, RhoGEF and PH domain containing 4 increases expression ISO 2-butenal results in increased expression of FGD4 mRNA CTD PMID:20471460 NCBI chr11:97,904,182...98,055,190 JBrowse link
G Flcn folliculin increases expression ISO 2-butenal results in increased expression of FLCN mRNA CTD PMID:20471460 NCBI chr10:45,088,164...45,107,581 JBrowse link
G Frmd4a FERM domain containing 4A decreases expression ISO 2-butenal results in decreased expression of FRMD4A mRNA CTD PMID:20471460 NCBI chr17:73,667,787...74,258,487 JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO 2-butenal results in increased expression of GABARAPL1 mRNA CTD PMID:20471460 NCBI chr 4:164,666,332...164,675,474 JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO 2-butenal results in decreased expression of GAS1 mRNA CTD PMID:20471460 NCBI chr17:4,487,716...4,490,701 JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO 2-butenal results in decreased expression of GAS5 mRNA CTD PMID:20471460 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gdf6 growth differentiation factor 6 decreases expression ISO 2-butenal results in decreased expression of GDF6 mRNA CTD PMID:20471460 NCBI chr 5:27,793,561...27,809,884 JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO 2-butenal results in increased expression of GEM mRNA CTD PMID:20471460 NCBI chr 5:25,214,309...25,225,222 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases activity EXP 2-butenal results in decreased activity of GGT1 protein CTD PMID:31345100 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO 2-butenal results in decreased expression of GLI2 mRNA CTD PMID:20471460 NCBI chr13:29,946,882...30,163,589 JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP 2-butenal results in increased activity of GPT protein CTD PMID:33749501 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP 2-butenal results in decreased activity of GPX1 protein CTD PMID:30426860 PMID:31345100 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases metabolic processing
multiple interactions
increases expression
ISO
EXP
GSTP1 protein results in increased metabolism of 2-butenal
2-butenal binds to and results in decreased activity of GSTP1 protein
2-butenal results in increased expression of GSTP1 protein
CTD PMID:9463521 PMID:10799737 PMID:11600134 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Gtf3c4 general transcription factor IIIC subunit 4 decreases expression ISO 2-butenal results in decreased expression of GTF3C4 mRNA CTD PMID:20471460 NCBI chr 3:12,154,803...12,172,795 JBrowse link
G Gxylt1 glucoside xylosyltransferase 1 decreases expression ISO 2-butenal results in decreased expression of GXYLT1 mRNA CTD PMID:20471460 NCBI chr 7:124,400,896...124,434,682 JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 decreases expression ISO 2-butenal results in decreased expression of HIPK2 mRNA CTD PMID:20471460 NCBI chr 4:68,399,358...68,586,404 JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO 2-butenal results in decreased expression of HMGA2 mRNA CTD PMID:20471460 NCBI chr 7:57,762,710...57,884,555 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; Acetylcysteine inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]
2-butenal results in increased expression of HMOX1 mRNA; 2-butenal results in increased expression of HMOX1 protein
CTD PMID:20471460 PMID:21238556 PMID:28947239 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 2-butenal results in increased expression of HSPA1A mRNA CTD PMID:20471460 NCBI chr20:3,875,411...3,877,866 JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO 2-butenal results in increased expression of HSPA1L mRNA CTD PMID:20471460 NCBI chr20:3,848,843...3,855,571 JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression
multiple interactions
ISO 2-butenal results in increased expression of HSPA6 mRNA
[2-butenal co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HSPA6 mRNA
CTD PMID:20471460 PMID:24849683 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Htra3 HtrA serine peptidase 3 increases expression ISO 2-butenal results in increased expression of HTRA3 mRNA CTD PMID:20471460 NCBI chr14:75,068,917...75,097,315 JBrowse link
G Hus1b HUS1 checkpoint clamp component B increases expression ISO 2-butenal results in increased expression of HUS1B mRNA CTD PMID:20471460 NCBI chr17:33,534,032...33,535,199 JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO 2-butenal results in decreased expression of ID1 mRNA CTD PMID:20471460 NCBI chr 3:161,671,525...161,672,691 JBrowse link
G Ifng interferon gamma decreases secretion
increases expression
ISO
EXP
2-butenal results in decreased secretion of IFNG protein
2-butenal results in increased expression of IFNG protein
CTD PMID:17491020 PMID:30426860 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ikzf4 IKAROS family zinc finger 4 decreases expression ISO 2-butenal results in decreased expression of IKZF4 mRNA CTD PMID:20471460 NCBI chr 7:1,063,283...1,102,940 JBrowse link
G Il10 interleukin 10 decreases secretion ISO 2-butenal results in decreased secretion of IL10 protein CTD PMID:17491020 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il11 interleukin 11 increases expression ISO 2-butenal results in increased expression of IL11 mRNA CTD PMID:20471460 NCBI chr 1:69,069,829...69,076,129 JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
EXP
ISO
2-butenal results in decreased expression of IL1B protein
2-butenal results in decreased expression of IL1B mRNA
2-butenal results in increased expression of IL1B protein
CTD PMID:20471460 PMID:23000924 PMID:30426860 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 decreases secretion ISO 2-butenal results in decreased secretion of IL2 protein CTD PMID:17491020 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il24 interleukin 24 increases expression ISO 2-butenal results in increased expression of IL24 mRNA CTD PMID:20471460 NCBI chr13:44,905,362...44,910,760 JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
ISO
EXP
2-butenal results in decreased expression of IL6 mRNA
2-butenal results in increased expression of IL6 protein
CTD PMID:20471460 PMID:30426860 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Il7 interleukin 7 increases expression ISO 2-butenal results in increased expression of IL7 mRNA CTD PMID:20471460 NCBI chr 2:96,142,523...96,186,282 JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO 2-butenal results in decreased expression of INHBA mRNA CTD PMID:20471460 NCBI chr17:53,787,159...53,810,942 JBrowse link
G Itgb8 integrin subunit beta 8 multiple interactions ISO [2-butenal co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ITGB8 mRNA CTD PMID:24849683 NCBI chr 6:146,267,982...146,351,245 JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression ISO 2-butenal results in increased expression of JMJD6 mRNA CTD PMID:20471460 NCBI chr10:102,041,131...102,047,182 JBrowse link
G Kmt2a lysine methyltransferase 2A decreases expression ISO 2-butenal results in decreased expression of KMT2A mRNA CTD PMID:20471460 NCBI chr 8:54,013,547...54,089,219 JBrowse link
G Krt34 keratin 34 increases expression ISO 2-butenal results in increased expression of KRT34 mRNA CTD PMID:20471460 NCBI chr10:85,470,391...85,474,501 JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase decreases expression ISO 2-butenal results in decreased expression of LNPEP mRNA CTD PMID:20471460 NCBI chr 1:66,931,712...67,027,610 JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma decreases expression ISO 2-butenal results in decreased expression of LPP mRNA CTD PMID:20471460 NCBI chr11:89,292,060...89,933,973 JBrowse link
G Lrp8 LDL receptor related protein 8 decreases expression ISO 2-butenal results in decreased expression of LRP8 mRNA CTD PMID:20471460 NCBI chr 5:127,792,236...127,864,207 JBrowse link
G Lrrc58 leucine rich repeat containing 58 decreases expression ISO 2-butenal results in decreased expression of LRRC58 mRNA CTD PMID:20471460 NCBI chr11:62,850,507...62,862,829 JBrowse link
G Lrrc70 leucine rich repeat containing 70 increases expression ISO 2-butenal results in increased expression of LRRC70 mRNA CTD PMID:20471460 NCBI chr 2:38,215,871...38,218,476 JBrowse link
G Luc7l3 LUC7-like 3 pre-mRNA splicing factor decreases expression ISO 2-butenal results in decreased expression of CROP mRNA CTD PMID:20471460 NCBI chr10:79,737,457...79,773,478 JBrowse link
G Ly6k lymphocyte antigen 6 family member K increases expression ISO 2-butenal results in increased expression of LY6K mRNA CTD PMID:20471460 NCBI chr 7:106,683,749...106,712,802 JBrowse link
G Lyrm7 LYR motif containing 7 decreases expression ISO 2-butenal results in decreased expression of LYRM7 mRNA CTD PMID:20471460 NCBI chr10:38,964,299...38,983,628 JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 2-butenal results in decreased expression of MAT2A mRNA CTD PMID:20471460 NCBI chr 4:106,048,043...106,053,612 JBrowse link
G Mideas mitotic deacetylase associated SANT domain protein decreases expression ISO 2-butenal results in decreased expression of MIDEAS mRNA CTD PMID:20471460 NCBI chr 6:103,784,779...103,854,470 JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 2-butenal results in increased expression of MMP3 mRNA CTD PMID:20471460 NCBI chr 8:12,925,267...12,938,828 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases secretion
increases expression
ISO 2-butenal results in increased secretion of MMP9 protein
2-butenal results in increased expression of MMP9 mRNA
CTD PMID:28947239 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Mms22l MMS22-like, DNA repair protein decreases expression ISO 2-butenal results in decreased expression of MMS22L mRNA CTD PMID:20471460 NCBI chr 5:38,197,707...38,313,745 JBrowse link
G Mob1b MOB kinase activator 1B decreases expression ISO 2-butenal results in decreased expression of MOB1B mRNA CTD PMID:20471460 NCBI chr14:19,333,058...19,365,845 JBrowse link
G Mprip myosin phosphatase Rho interacting protein decreases expression ISO 2-butenal results in decreased expression of MPRIP mRNA CTD PMID:20471460 NCBI chr10:44,953,472...45,073,388 JBrowse link
G Mrtfb myocardin related transcription factor B decreases expression ISO 2-butenal results in decreased expression of MRTFB mRNA CTD PMID:20471460 NCBI chr10:1,116,315...1,278,106 JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 decreases expression EXP 2-butenal results in decreased expression of ATP6 mRNA CTD PMID:33749501
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP 2-butenal results in decreased expression of COX1 mRNA CTD PMID:33749501
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression EXP 2-butenal results in decreased expression of COX3 mRNA CTD PMID:33749501
G Mt-cyb mitochondrially encoded cytochrome b decreases expression EXP 2-butenal results in decreased expression of CYTB mRNA CTD PMID:33749501 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression EXP 2-butenal results in decreased expression of ND1 mRNA CTD PMID:33749501 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 decreases expression EXP 2-butenal results in decreased expression of ND2 mRNA CTD PMID:33749501 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 decreases expression ISO 2-butenal results in decreased expression of MT1E mRNA CTD PMID:20471460 NCBI chr17:79,695,812...79,696,200 JBrowse link
G Mtcl2 microtubule crosslinking factor 2 decreases expression ISO 2-butenal results in decreased expression of MTCL2 mRNA CTD PMID:20471460 NCBI chr 3:145,669,102...145,741,578 JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO 2-butenal results in increased expression of MXD1 mRNA CTD PMID:20471460 NCBI chr 4:120,654,731...120,678,972 JBrowse link
G N4bp1 Nedd4 binding protein 1 decreases expression ISO 2-butenal results in decreased expression of N4BP1 mRNA CTD PMID:20471460 NCBI chr19:20,222,811...20,273,570 JBrowse link
G Ncor2 nuclear receptor co-repressor 2 decreases expression ISO 2-butenal results in decreased expression of NCOR2 mRNA CTD PMID:20471460 NCBI chr12:37,127,736...37,289,612 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
decreases response to substance
ISO 2-butenal affects the localization of NFE2L2 protein
NFE2L2 protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein]
NFE2L2 protein results in decreased susceptibility to 2-butenal
CTD PMID:21238556 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfic nuclear factor I/C decreases expression ISO 2-butenal results in decreased expression of NFIC mRNA CTD PMID:20471460 NCBI chr 7:8,278,210...8,309,936 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects expression ISO 2-butenal affects the expression of NFKB1 mRNA CTD PMID:28947239 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO 2-butenal results in decreased expression of NFKBIA mRNA CTD PMID:20471460 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nfkbiz NFKB inhibitor zeta decreases expression ISO 2-butenal results in decreased expression of NFKBIZ mRNA CTD PMID:20471460 NCBI chr11:58,251,720...58,279,767 JBrowse link
G Nhlrc2 NHL repeat containing 2 decreases expression ISO 2-butenal results in decreased expression of NHLRC2 mRNA CTD PMID:20471460 NCBI chr 1:265,594,915...265,655,647 JBrowse link
G Nos2 nitric oxide synthase 2 increases activity EXP 2-butenal results in increased activity of INOS protein CTD PMID:30426860 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nppb natriuretic peptide B increases expression EXP 2-butenal results in increased expression of NPPB protein CTD PMID:30426860 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Or5t16 olfactory receptor family 5 subfamily T member 16 decreases expression ISO 2-butenal results in decreased expression of OR5T2 mRNA CTD PMID:20471460 NCBI chr 3:72,096,981...72,097,916 JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 decreases expression
increases expression
ISO 2-butenal results in decreased expression of PAG1 mRNA
2-butenal results in increased expression of PAG1 mRNA
CTD PMID:20471460 NCBI chr 2:91,935,378...92,076,937 JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression ISO 2-butenal results in decreased expression of POU2F1 mRNA CTD PMID:20471460 NCBI chr13:80,653,602...80,796,279 JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 2-butenal results in increased expression of PPP1R15A mRNA CTD PMID:20471460 NCBI chr 1:105,136,521...105,139,596 JBrowse link
G Prag1 PEAK1 related kinase activating pseudokinase 1 decreases expression ISO 2-butenal results in decreased expression of PRAG1 mRNA CTD PMID:20471460 NCBI chr16:62,791,249...62,844,532 JBrowse link
G Prickle2 prickle planar cell polarity protein 2 decreases expression ISO 2-butenal results in decreased expression of PRICKLE2 mRNA CTD PMID:20471460 NCBI chr 4:124,869,655...125,214,862 JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PRKCD protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein] CTD PMID:21238556 NCBI chr16:5,775,681...5,806,122 JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO 2-butenal results in decreased expression of PTGER4 mRNA CTD PMID:20471460 NCBI chr 2:56,061,699...56,074,594 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-butenal CTD PMID:11524419 NCBI chr 5:78,579,060...78,597,671 JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 decreases expression ISO 2-butenal results in decreased expression of PTPN3 mRNA CTD PMID:20471460 NCBI chr 5:76,703,687...76,822,584 JBrowse link
G Ptx3 pentraxin 3 decreases expression
increases expression
ISO 2-butenal results in decreased expression of PTX3 mRNA
2-butenal results in increased expression of PTX3 mRNA
CTD PMID:20471460 NCBI chr 2:152,797,563...152,803,372 JBrowse link
G Pwwp2a PWWP domain containing 2A decreases expression ISO 2-butenal results in decreased expression of PWWP2A mRNA CTD PMID:20471460 NCBI chr10:28,155,509...28,195,255 JBrowse link
G Rab22a RAB22A, member RAS oncogene family decreases expression ISO 2-butenal results in decreased expression of RAB22A mRNA CTD PMID:20471460 NCBI chr 3:162,459,727...162,506,129 JBrowse link
G Rab3gap2 RAB3 GTPase activating non-catalytic protein subunit 2 decreases expression ISO 2-butenal results in decreased expression of RAB3GAP2 mRNA CTD PMID:20471460 NCBI chr13:96,757,430...96,828,930 JBrowse link
G Rbm33 RNA binding motif protein 33 increases expression ISO 2-butenal results in increased expression of RBM33 mRNA CTD PMID:20471460 NCBI chr 4:6,980,807...7,088,334 JBrowse link
G Rcor3 REST corepressor 3 decreases expression ISO 2-butenal results in decreased expression of RCOR3 mRNA CTD PMID:20471460 NCBI chr13:103,624,966...103,665,565 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2-butenal inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:23000924 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Ric1 RIC1 homolog, RAB6A GEF complex partner 1 decreases expression ISO 2-butenal results in decreased expression of RIC1 mRNA CTD PMID:20471460 NCBI chr 1:227,285,510...227,384,553 JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO 2-butenal results in decreased expression of RO60 mRNA CTD PMID:20471460 NCBI chr13:55,499,514...55,520,504 JBrowse link
G Rrp15 ribosomal RNA processing 15 homolog decreases expression ISO 2-butenal results in decreased expression of RRP15 mRNA CTD PMID:20471460 NCBI chr13:98,276,276...98,299,357 JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO 2-butenal results in decreased expression of RUNX1T1 mRNA CTD PMID:20471460 NCBI chr 5:27,187,674...27,338,070 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases activity
ISO [2-butenal co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein
2-butenal results in increased activity of SLC2A1 protein
CTD PMID:20955755 NCBI chr 5:138,002,522...138,030,742 JBrowse link
G Slc35a3 solute carrier family 35 member A3 decreases expression ISO 2-butenal results in decreased expression of SLC35A3 mRNA CTD PMID:20471460 NCBI chr 2:204,620,103...204,659,319 JBrowse link
G Snord22 small nucleolar RNA, C/D box 22 decreases expression ISO 2-butenal results in decreased expression of SNORD22 mRNA CTD PMID:20471460 NCBI chr11:9,097,799...9,097,923 JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP 2-butenal results in decreased activity of SOD1 protein CTD PMID:30426860 PMID:31345100 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO 2-butenal results in decreased expression of SOX9 mRNA CTD PMID:20471460 NCBI chr10:98,305,744...98,311,250 JBrowse link
G Spag9 sperm associated antigen 9 increases expression ISO 2-butenal results in increased expression of SPAG9 mRNA CTD PMID:20471460 NCBI chr10:78,943,439...79,077,797 JBrowse link
G Tent4a terminal nucleotidyltransferase 4A decreases expression ISO 2-butenal results in decreased expression of TENT4A mRNA CTD PMID:20471460 NCBI chr 1:33,765,949...33,799,405 JBrowse link
G Tex19.2 testis expressed gene 19.2 increases expression ISO 2-butenal results in increased expression of TEX19 mRNA CTD PMID:20471460 NCBI chr10:106,379,757...106,382,344 JBrowse link
G Thbd thrombomodulin decreases expression ISO 2-butenal results in decreased expression of THBD mRNA CTD PMID:20471460 NCBI chr 3:156,316,526...156,320,178 JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator decreases expression ISO 2-butenal results in decreased expression of TICRR mRNA CTD PMID:20471460 NCBI chr 1:143,006,989...143,048,836 JBrowse link
G Tnf tumor necrosis factor decreases secretion
decreases expression
increases expression
ISO
EXP
2-butenal results in decreased secretion of TNF protein
2-butenal results in decreased expression of TNF protein
2-butenal results in increased expression of TNF mRNA
2-butenal results in increased expression of TNF protein
CTD PMID:17491020 PMID:23000924 PMID:28947239 PMID:30426860 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO 2-butenal results in decreased expression of TNFAIP3 mRNA CTD PMID:20471460 NCBI chr 1:15,528,921...15,543,993 JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression ISO 2-butenal results in decreased expression of TNIK mRNA CTD PMID:20471460 NCBI chr 2:113,112,937...113,511,341 JBrowse link
G Tp53 tumor protein p53 increases expression EXP 2-butenal results in increased expression of TP53 protein CTD PMID:23535401 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 decreases expression ISO 2-butenal results in decreased expression of TRAF3IP1 mRNA CTD PMID:20471460 NCBI chr 9:99,521,176...99,557,966 JBrowse link
G Tram2 translocation associated membrane protein 2 decreases expression ISO 2-butenal results in decreased expression of TRAM2 mRNA CTD PMID:20471460 NCBI chr 9:23,419,204...23,498,745 JBrowse link
G Trappc10 trafficking protein particle complex subunit 10 decreases expression ISO 2-butenal results in decreased expression of TRAPPC10 mRNA CTD PMID:20471460 NCBI chr20:10,438,404...10,498,740 JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 2-butenal results in increased expression of TRIB3 mRNA CTD PMID:20471460 NCBI chr 3:161,269,939...161,275,533 JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO 2-butenal results in decreased expression of TRIM38 mRNA CTD PMID:20471460 NCBI chr17:41,351,857...41,365,021 JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity EXP
ISO
2-butenal results in increased activity of TRPA1 protein CTD PMID:18568077 PMID:32634517 NCBI chr 5:9,163,060...9,217,325 JBrowse link
G Ttpal alpha tocopherol transfer protein like decreases expression ISO 2-butenal results in decreased expression of TTPAL mRNA CTD PMID:20471460 NCBI chr 3:152,278,246...152,296,550 JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO 2-butenal results in decreased expression of TXNIP mRNA CTD PMID:20471460 NCBI chr 2:186,781,933...186,785,736 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 2-butenal results in increased expression of TXNRD1 mRNA CTD PMID:20471460 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Ubc ubiquitin C increases expression ISO 2-butenal results in increased expression of UBC mRNA CTD PMID:20471460 NCBI chr12:36,899,673...36,905,275 JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO 2-butenal results in increased expression of UPP1 mRNA CTD PMID:20471460 NCBI chr14:88,023,155...88,043,036 JBrowse link
G Usf3 upstream transcription factor family member 3 decreases expression ISO 2-butenal results in decreased expression of USF3 mRNA CTD PMID:20471460 NCBI chr11:69,976,658...70,035,809 JBrowse link
G Usp31 ubiquitin specific peptidase 31 decreases expression ISO 2-butenal results in decreased expression of USP31 mRNA CTD PMID:20471460 NCBI chr 1:176,211,334...176,278,183 JBrowse link
G Ypel2 yippee-like 2 increases expression ISO 2-butenal results in increased expression of YPEL2 mRNA CTD PMID:20471460 NCBI chr10:72,243,591...72,301,124 JBrowse link
G Zbed3 zinc finger, BED-type containing 3 decreases expression ISO 2-butenal results in decreased expression of ZBED3 mRNA CTD PMID:20471460 NCBI chr 2:26,587,620...26,600,177 JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO 2-butenal results in decreased expression of ZBTB24 mRNA CTD PMID:20471460 NCBI chr20:46,525,982...46,546,363 JBrowse link
G Zc3hav1l ZC3HAV1 like decreases expression ISO 2-butenal results in decreased expression of ZC3HAV1L mRNA CTD PMID:20471460 NCBI chr 4:66,994,192...67,003,207 JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO 2-butenal results in increased expression of ZFAND2A mRNA CTD PMID:20471460 NCBI chr12:15,161,601...15,172,679 JBrowse link
G Zfhx4 zinc finger homeobox 4 decreases expression ISO 2-butenal results in decreased expression of ZFHX4 mRNA CTD PMID:20471460 NCBI chr 2:96,224,763...96,408,245 JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 decreases expression ISO 2-butenal results in decreased expression of ZFP36L2 mRNA CTD PMID:20471460 NCBI chr 6:16,242,622...16,246,662 JBrowse link
G Zfp652 zinc finger protein 652 decreases expression ISO 2-butenal results in decreased expression of ZNF652 mRNA CTD PMID:20471460 NCBI chr10:81,123,326...81,203,153 JBrowse link
G Zfp786 zinc finger protein 786 decreases expression ISO 2-butenal results in decreased expression of ZNF786 mRNA CTD PMID:20471460 NCBI chr 4:76,822,383...76,840,943 JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 decreases expression ISO 2-butenal results in decreased expression of ZHX3 mRNA CTD PMID:20471460 NCBI chr 3:149,417,787...149,548,671 JBrowse link
G Zkscan1 zinc finger with KRAB and SCAN domains 1 decreases expression ISO 2-butenal results in decreased expression of ZKSCAN1 mRNA CTD PMID:20471460 NCBI chr12:16,966,287...16,987,680 JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 decreases expression ISO 2-butenal results in decreased expression of ZMIZ1 mRNA CTD PMID:20471460 NCBI chr16:1,027,083...1,232,616 JBrowse link
G Znf783 zinc finger protein 783 decreases expression ISO 2-butenal results in decreased expression of ZNF783 mRNA CTD PMID:20471460
G Znfx1 zinc finger, NFX1-type containing 1 decreases expression ISO 2-butenal results in decreased expression of ZNFX1 mRNA CTD PMID:20471460 NCBI chr 3:176,183,111...176,210,812 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              olefinic compound 16992
                enal 3111
                  crotonaldehyde 197
                    S-(4-oxobutan-2-yl)glutathione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          formyl group 9386
                                            aldehyde 9386
                                              alpha,beta-unsaturated aldehyde 3111
                                                enal 3111
                                                  crotonaldehyde 197
                                                    S-(4-oxobutan-2-yl)glutathione 0
paths to the root