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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:celecoxib
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Accession:CHEBI:41423 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Synonyms:exact_synonym: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
 related_synonym: Celebrex;   Formula=C17H14F3N3O2S;   InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25);   InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N;   SMILES=CC1=CC=C(C=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F;   celecoxibum;   p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
 alt_id: CHEBI:3520;   CHEBI:41418
 xref: CAS:169590-42-5;   CAS:184007-95-2;   Chemspider:2562;   DrugBank:DB00482;   Drug_Central:568;   FooDB:FDB023586;   HMDB:HMDB0005014;   KEGG:C07589;   KEGG:D00567;   LINCS:LSM-2032
 xref_mesh: MESH:C105934
 xref: PDBeChem:CEL;   PMID:14736236;   PMID:16580269;   PMID:17983259;   PMID:18405470;   PMID:19137124;   PMID:19203891;   PMID:19955429;   PMID:20709553;   PMID:21348927;   PMID:21955617;   PMID:22141388;   PMID:22419293;   PMID:22971036;   PMID:23296687;   PMID:23506230;   PMID:27756840;   PMID:28166217;   Reaxys:8280770;   Wikipedia:Celecoxib


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celecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Celecoxib results in decreased activity of ABCB11 protein
Celecoxib inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:22646477 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
increases expression
decreases activity
increases methylation		 ISO Celecoxib results in decreased expression of ABCB1 protein
[Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Tamoxifen
Celecoxib results in increased expression of ABCB1 mRNA
Celecoxib results in decreased activity of ABCB1A protein
Celecoxib results in increased methylation of ABCB1 promoter		 CTD PMID:15458769 PMID:19562670 PMID:21745461 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression
increases expression		 ISO Celecoxib results in decreased expression of ABCC1 mRNA
Celecoxib results in increased expression of ABCC1 mRNA		 CTD PMID:18202791 PMID:21745461 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Celecoxib results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Celecoxib results in increased expression of ABCC4 mRNA; Celecoxib results in increased expression of ABCC4 protein CTD PMID:18690847 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Celecoxib results in increased expression of ABCC5 mRNA; Celecoxib results in increased expression of ABCC5 protein CTD PMID:18690847 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 affects expression ISO Celecoxib affects the expression of ABCF1 mRNA CTD PMID:20562220 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433 		JBrowse link
G Abcf2 ATP binding cassette subfamily F member 2 affects expression ISO Celecoxib affects the expression of ABCF2 mRNA CTD PMID:20562220 NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Celecoxib results in decreased expression of ABCG2 mRNA CTD PMID:18202791 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acan aggrecan affects expression EXP Celecoxib affects the expression of ACAN mRNA CTD PMID:16273290 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity		 ISO donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Celecoxib results in increased activity of ACHE protein] CTD PMID:18208924 PMID:18343489 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Celecoxib results in decreased expression of ACTA2 mRNA; Celecoxib results in decreased expression of ACTA2 protein		 CTD PMID:16420518 PMID:19201774 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akap1 A-kinase anchoring protein 1 affects expression ISO Celecoxib affects the expression of AKAP1 mRNA CTD PMID:20562220 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
increases phosphorylation
decreases activity
decreases expression
decreases phosphorylation
affects phosphorylation		 ISO
EXP		 AKT1 protein results in decreased susceptibility to Celecoxib
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with Docetaxel] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased phosphorylation of AKT1 protein; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]; Celecoxib results in decreased phosphorylation of and results in decreased activity of AKT1 protein
Celecoxib analog results in increased phosphorylation of AKT1 protein; Celecoxib results in increased phosphorylation of AKT1 protein
Celecoxib results in decreased activity of AKT1 protein
Celecoxib results in decreased expression of AKT1 protein
Celecoxib analog results in decreased phosphorylation of AKT1 protein; Celecoxib results in decreased phosphorylation of AKT1 protein
Celecoxib affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]		 CTD PMID:10753955 PMID:12000750 PMID:12464646 PMID:14654083 PMID:15499625 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions EXP Celecoxib inhibits the reaction [Gentamicins results in decreased expression of ALB protein] CTD PMID:31628940 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects localization EXP celecoxib increases the release of aldh2 protein from the mitochondrial matrix RGD PMID:29491208 RGD:15036803 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C affects expression ISO Celecoxib affects the expression of ALDOC mRNA CTD PMID:20562220 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein] CTD PMID:12376474 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Apod apolipoprotein D multiple interactions ISO [Celecoxib co-treated with Paraquat] results in increased expression of APOD mRNA; Celecoxib inhibits the reaction [Oxidopamine results in decreased expression of APOD mRNA] CTD PMID:33160981 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G App amyloid beta precursor protein affects cleavage ISO Celecoxib affects the cleavage of APP protein CTD PMID:14690522 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 EXP
ISO		 [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein
Celecoxib results in decreased expression of AR protein		 CTD PMID:15570007 PMID:17908994 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 affects expression ISO Celecoxib affects the expression of ATP6AP2 mRNA CTD PMID:20562220 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) affects expression ISO Celecoxib affects the expression of ATP9A mRNA CTD PMID:20562220 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
decreases response to substance		 ISO
EXP		 Celecoxib analog results in increased expression of BAK1 protein; Celecoxib results in increased expression of BAK1 mRNA; Celecoxib results in increased expression of BAK1 protein
BAK1 results in decreased susceptibility to Celecoxib		 CTD PMID:18349538 PMID:19428934 PMID:19682443 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases activity
multiple interactions
increases expression		 ISO Celecoxib results in decreased expression of BAX mRNA
Celecoxib results in increased activity of BAX protein
[docetaxel co-treated with Celecoxib] results in increased expression of BAX protein; [tetracycline CMT-3 co-treated with Celecoxib] results in increased expression of BAX protein; BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; Celecoxib results in increased activity of and results in increased localization of BAX protein
Celecoxib results in increased expression of BAX protein		 CTD PMID:15688368 PMID:17342322 PMID:17368424 PMID:17952603 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases response to substance
multiple interactions
increases expression		 ISO BBC3 results in increased susceptibility to Celecoxib
BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]
Celecoxib results in increased expression of BBC3; Celecoxib results in increased expression of BBC3 protein		 CTD PMID:17368424 PMID:18760266 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO Celecoxib results in increased cleavage of and results in increased localization of BCAR1 protein CTD PMID:16353145 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [docetaxel results in increased expression of BCL2 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased expression of BCL2 protein]; tetraarsenic tetrasulfide promotes the reaction [Celecoxib results in decreased expression of BCL2 protein]
Celecoxib results in increased expression of BCL2 mRNA
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein]		 CTD PMID:15688368 PMID:15911099 PMID:16230411 PMID:16391871 PMID:17342322 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
increases expression		 ISO [Celecoxib co-treated with docetaxel] results in decreased expression of BCL2L1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased expression of BCL2L1 protein; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in decreased expression of BCL2L1 protein
Celecoxib results in increased expression of BCL2L1 mRNA		 CTD PMID:15688368 PMID:17342322 PMID:20104024 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions		 ISO Celecoxib results in increased cleavage of BID protein
[ABT-737 co-treated with Celecoxib] results in increased cleavage of BID protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]		 CTD PMID:15197583 PMID:15572759 PMID:20104024 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects binding
decreases expression
increases expression		 ISO [Celecoxib binds to BIRC5 promoter] which results in decreased expression of BIRC5 mRNA; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]
Celecoxib results in decreased expression of BIRC5 mRNA; Celecoxib results in decreased expression of BIRC5 protein
Celecoxib results in increased expression of BIRC5 mRNA
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein		 CTD PMID:16004971 PMID:16123214 PMID:16707021 PMID:17270149 PMID:17342322 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO Celecoxib binds to and results in decreased activity of CA2 protein
Celecoxib results in decreased activity of CA2 protein		 CTD PMID:16858005 PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Celecoxib binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp3 caspase 3 decreases expression
increases activity
multiple interactions
increases expression
increases cleavage		 ISO
EXP		 Celecoxib analog results in decreased expression of CASP3 protein; Celecoxib results in decreased expression of CASP3 protein
Celecoxib results in increased activity of CASP3; Celecoxib results in increased activity of CASP3 protein
3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP3 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP3 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [Docetaxel results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib results in increased activity of and results in increased expression of CASP3 protein; Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein; Docetaxel promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in increased expression of CASP3 protein
Celecoxib inhibits the reaction [aristolochic acid I results in increased cleavage of CASP3 protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]		 CTD PMID:10753955 PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein] CTD PMID:15572759 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases activity
affects activity
multiple interactions		 ISO Celecoxib results in increased activity of CASP7; Celecoxib results in increased activity of CASP7 protein
Celecoxib analog affects the activity of CASP7 protein
Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]		 CTD PMID:15572759 PMID:18202791 PMID:18485224 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage		 ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP8 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
Celecoxib analog results in increased activity of CASP8 protein; Celecoxib results in increased activity of CASP8 protein		 CTD PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 PMID:18172863 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP9 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP9 protein; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]
Celecoxib results in increased activity of CASP9 protein		 CTD PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 PMID:15688368 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 ISO Celecoxib results in decreased expression of CAT protein
Celecoxib inhibits the reaction [Smoke results in increased activity of CAT protein]		 CTD PMID:18848576 PMID:21280565 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 increases expression ISO Celecoxib results in increased expression of CAV1 protein CTD PMID:18848576 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO
EXP		 Celecoxib inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
Celecoxib results in decreased expression of CCL2 mRNA
Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]		 CTD PMID:12902868 PMID:20039930 PMID:24530660 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Celecoxib results in decreased expression of CCL5 mRNA CTD PMID:12902868 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Celecoxib affects the expression of CCNB1 CTD PMID:19846907 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression
multiple interactions		 ISO
EXP		 Celecoxib affects the expression of CCND1
Celecoxib results in decreased expression of CCND1 mRNA; Celecoxib results in decreased expression of CCND1 protein
Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib promotes the reaction [Gemcitabine results in decreased expression of CCND1 protein]
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of CCND1 protein]		 CTD PMID:15489888 PMID:16060994 PMID:17270149 PMID:17908994 PMID:19846907 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Celecoxib results in decreased expression of CCND2 mRNA; Celecoxib results in decreased expression of CCND2 protein CTD PMID:19428934 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CCR2 mRNA CTD PMID:12902868 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO Celecoxib results in decreased expression of CCR5 mRNA CTD PMID:12902868 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA] CTD PMID:19194550 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
multiple interactions		 ISO Celecoxib analog results in increased expression of CDH1 protein; Celecoxib results in increased expression of CDH1 mRNA; Celecoxib results in increased expression of CDH1 protein
Celecoxib affects the expression of CDH1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]		 CTD PMID:17224647 PMID:19682443 PMID:29932878 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Celecoxib results in decreased expression of CDK2 protein; Celecoxib results in decreased expression of CDK2 protein modified form CTD PMID:16136956 PMID:19428934 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Celecoxib results in decreased expression of CDK4 protein CTD PMID:16136956 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
increases localization		 ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1A protein]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1A protein]
Celecoxib results in increased expression of CDKN1A mRNA; Celecoxib results in increased expression of CDKN1A protein
Celecoxib results in increased localization of CDKN1A protein		 CTD PMID:16136956 PMID:18172863 PMID:19141979 PMID:19706164 PMID:21737646 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1B protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]
Celecoxib results in increased expression of CDKN1B mRNA; Celecoxib results in increased expression of CDKN1B protein		 CTD PMID:18172863 PMID:19428934 PMID:21737646 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of CEBPA mRNA] CTD PMID:19247274 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Celecoxib results in decreased expression of CFLAR CTD PMID:17145853 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
Celecoxib results in decreased expression of COL1A1 mRNA		 CTD PMID:16420518 PMID:19201774 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein] CTD PMID:32416088 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crp C-reactive protein decreases expression ISO Celecoxib results in decreased expression of CRP CTD PMID:12551863 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of CRYAB mRNA] CTD PMID:16420518 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Celecoxib affects the localization of CTNNB1 protein; Celecoxib analog affects the localization of CTNNB1 protein CTD PMID:19682443 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [Celecoxib co-treated with Paraquat] results in increased expression of CTSD mRNA; Celecoxib inhibits the reaction [Oxidopamine results in decreased expression of CTSD mRNA]; Celecoxib inhibits the reaction [Paraquat results in increased expression of CTSD mRNA] CTD PMID:33160981 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO Celecoxib results in decreased expression of CXCR1 mRNA CTD PMID:12902868 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CXCR2 mRNA CTD PMID:12902868 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Celecoxib results in decreased activity of CYP19A1 protein
Celecoxib results in decreased expression of CYP19A1 mRNA		 CTD PMID:15964185 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Celecoxib results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dap3 death associated protein 3 affects expression ISO Celecoxib affects the expression of DAP3 mRNA CTD PMID:20562220 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
affects expression
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]
Celecoxib analog affects the expression of DDIT3 protein
Celecoxib results in increased expression of DDIT3; Celecoxib results in increased expression of DDIT3 protein		 CTD PMID:16463383 PMID:18485224 PMID:20104024 PMID:21567098 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Des desmin multiple interactions
increases expression		 ISO PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA] CTD PMID:18089846 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein] CTD PMID:15572759 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Celecoxib affects the expression of DHCR24 mRNA CTD PMID:20562220 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein] CTD PMID:25656942 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]; Celecoxib results in decreased susceptibility to [BQ 788 binds to and results in decreased activity of EDNRB protein] CTD PMID:24462674 PMID:25656942 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 PMID:17908994 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Emc3 ER membrane protein complex subunit 3 affects expression ISO Celecoxib affects the expression of EMC3 mRNA CTD PMID:20562220 NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029 		JBrowse link
G Fadd Fas associated via death domain multiple interactions
affects response to substance		 ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]
FADD affects the susceptibility to Celecoxib		 CTD PMID:15197583 PMID:15572759 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]
Celecoxib results in increased expression of FAS mRNA; Celecoxib results in increased expression of FAS protein		 CTD PMID:15197583 PMID:19141979 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases activity
multiple interactions		 ISO Celecoxib results in decreased activity of FASN protein
Dinoprostone promotes the reaction [Celecoxib results in decreased activity of FASN protein]		 CTD PMID:19159447 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
decreases expression
multiple interactions		 EXP
ISO		 Celecoxib affects the expression of FOS protein
Celecoxib results in decreased expression of FOS protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of FOS protein]		 CTD PMID:18988310 PMID:19463908 PMID:32416088 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Celecoxib results in increased expression of GDF15; Celecoxib results in increased expression of GDF15 mRNA
[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA; GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]		 CTD PMID:17257745 PMID:17959037 PMID:18089846 PMID:20067113 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gorasp2 golgi reassembly stacking protein 2 affects expression ISO Celecoxib affects the expression of GORASP2 mRNA CTD PMID:20562220 NCBI chr 3:55,474,448...55,503,570
Ensembl chr 3:55,474,757...55,503,576 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]; PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Celecoxib results in increased expression of GPX1 protein CTD PMID:20883674 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA] CTD PMID:21589914 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA] CTD PMID:21589914 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA] CTD PMID:21589914 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA] CTD PMID:21589914 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] CTD PMID:21589914 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA CTD PMID:21589914 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA CTD PMID:21589914 NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA CTD PMID:21589914 NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA] CTD PMID:21589914 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA] CTD PMID:21589914 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] CTD PMID:21589914 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA] CTD PMID:21589914 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA] CTD PMID:21589914 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions		 ISO Celecoxib results in decreased phosphorylation of GSK3B protein
GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]		 CTD PMID:17257745 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gss glutathione synthetase affects expression ISO Celecoxib affects the expression of GSS mRNA CTD PMID:20562220 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO Celecoxib results in increased expression of GSTP1 mRNA
PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]		 CTD PMID:18089846 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of HK2 mRNA] CTD PMID:27452194 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP		 Celecoxib results in increased expression of HMOX1 protein CTD PMID:19356721 PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Celecoxib co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Celecoxib results in increased expression of HSPA5 CTD PMID:21567098 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]
Celecoxib results in increased expression of ICAM1 mRNA; Celecoxib results in increased expression of ICAM1 protein		 CTD PMID:14762100 PMID:26513172 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IFNG protein] CTD PMID:32416088 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in decreased expression of IL10 protein]
Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]		 CTD PMID:16230411 PMID:24932515 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL17A protein] CTD PMID:32416088 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects secretion		 ISO
EXP		 Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Celecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of IL1B protein]
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Celecoxib affects the secretion of IL1B protein		 CTD PMID:14762100 PMID:15309881 PMID:16230411 PMID:16357062 PMID:19129380 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in increased expression of IL2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of IL2 protein] CTD PMID:24462674 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of IL6; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]; Celecoxib inhibits the reaction [IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of IL6 protein]		 CTD PMID:16702388 PMID:24285838 PMID:24530660 PMID:31048000 PMID:32416088 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Celecoxib inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of INS1] CTD PMID:19247274 PMID:20039930 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of JUN protein; Celecoxib promotes the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of JUN protein]		 CTD PMID:18172863 PMID:32416088 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lct lactase increases activity EXP Celecoxib results in increased activity of LCT protein CTD PMID:18604318 NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of LDHA mRNA] CTD PMID:27452194 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K2 protein CTD PMID:16123214 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO
EXP		 Celecoxib analog results in increased phosphorylation of MAPK1 protein
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK1 protein
Celecoxib analog results in decreased phosphorylation of MAPK1 protein; Celecoxib results in decreased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [Acetic Acid results in increased activity of MAPK1]; Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11891194 PMID:12464646 PMID:15499625 PMID:16463383 PMID:18988310 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK14 protein CTD PMID:16463383 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO
EXP		 Celecoxib analog results in increased phosphorylation of MAPK3 protein
Celecoxib analog results in decreased phosphorylation of MAPK3 protein; Celecoxib results in decreased phosphorylation of MAPK3 protein
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK3 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15499625 PMID:16463383 PMID:18988310 PMID:19682443 PMID:32416088 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Celecoxib inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]		 CTD PMID:16442704 PMID:32416088 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Celecoxib results in decreased expression of MCL1 protein CTD PMID:14654083 PMID:17952603 PMID:19665451 PMID:20836993 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET mRNA]; Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET protein] CTD PMID:11891194 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions
increases expression		 ISO [Celecoxib co-treated with Paraquat] results in increased expression of MITF mRNA; [Oxidopamine co-treated with Celecoxib] results in increased expression of MITF mRNA; Celecoxib inhibits the reaction [Paraquat results in increased expression of MITF mRNA]; Oxidopamine promotes the reaction [Celecoxib results in increased expression of MITF mRNA] CTD PMID:33160981 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions		 ISO Celecoxib results in decreased expression of MKI67
[FEC protocol co-treated with Celecoxib] results in decreased expression of MKI67 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of MKI67 protein]		 CTD PMID:16507397 PMID:20697803 PMID:32416088 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
affects expression		 ISO
EXP		 Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 mRNA]; Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 protein]
Celecoxib affects the expression of MMP2 mRNA
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]		 CTD PMID:16420518 PMID:18438340 PMID:21540248 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of MMP9 protein]
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]		 CTD PMID:16230411 PMID:16420518 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of MPO protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Celecoxib results in increased activity of MPO protein		 CTD PMID:15309881 PMID:21893697 PMID:24932515 PMID:31628940 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrps26 mitochondrial ribosomal protein S26 affects expression ISO Celecoxib affects the expression of MRPS26 mRNA CTD PMID:20562220 NCBI chr 3:117,769,220...117,770,883
Ensembl chr 3:117,769,100...117,770,885 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 affects expression ISO Celecoxib affects the expression of MTUS1 mRNA CTD PMID:20562220 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression ISO Celecoxib results in decreased expression of MVD CTD PMID:17224647 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Celecoxib analog results in decreased expression of MYC protein; Celecoxib results in decreased expression of MYC protein CTD PMID:19682443 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:15489888 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor affects expression EXP Celecoxib affects the expression of NGF mRNA CTD PMID:19129380 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Celecoxib results in increased expression of NGFR mRNA; Celecoxib results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein]		 CTD PMID:21893697 PMID:24932515 PMID:32416088 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Celecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; Celecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA] CTD PMID:19194550 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Celecoxib affects the localization of and results in increased activity of NR3C1 protein CTD PMID:15700047 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]] CTD PMID:16357062 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein affects expression ISO Celecoxib affects the expression of OXA1L mRNA CTD PMID:20562220 NCBI chr15:27,813,688...27,821,319
Ensembl chr15:27,813,625...27,821,319 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
affects cleavage
increases activity
increases cleavage		 ISO [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein]
Celecoxib analog affects the cleavage of PARP1 protein
Celecoxib results in increased activity of PARP1 protein
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein]		 CTD PMID:12824303 PMID:15572759 PMID:15688368 PMID:15911099 PMID:16123214 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Celecoxib results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19201774 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases activity
multiple interactions		 ISO Celecoxib analog results in decreased activity of PDPK1 protein; Celecoxib results in decreased activity of PDPK1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of and results in decreased expression of PDPK1 protein		 CTD PMID:12000750 PMID:15499625 PMID:18172863 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pdpn podoplanin decreases expression ISO Celecoxib results in decreased expression of PDPN mRNA CTD PMID:17285134 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO [Celecoxib co-treated with docetaxel] results in decreased expression of PLA2G4A protein; Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 PMID:16052515 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plin2 perilipin 2 increases expression ISO Celecoxib results in increased expression of PLIN2 mRNA CTD PMID:19415698 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases response to substance ISO PMAIP1 results in increased susceptibility to Celecoxib CTD PMID:19665451 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Poglut2 protein O-glucosyltransferase 2 affects expression ISO Celecoxib affects the expression of POGLUT2 mRNA CTD PMID:20562220 NCBI chr 9:46,256,388...46,268,714
Ensembl chr 9:46,256,390...46,268,532 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Celecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA] CTD PMID:22902858 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Celecoxib results in increased expression of PPARA mRNA; Celecoxib results in increased expression of PPARA protein CTD PMID:19415698 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Celecoxib analog results in decreased expression of PPARD protein; Celecoxib results in decreased expression of PPARD protein CTD PMID:19682443 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects localization
increases expression		 ISO
EXP		 2-chloro-5-nitrobenzanilide inhibits the reaction [Celecoxib affects the localization of PPARG protein]; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib affects the localization of PPARG protein]
Celecoxib results in increased expression of PPARG mRNA; Celecoxib results in increased expression of PPARG protein
Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]
[Celecoxib co-treated with docetaxel] results in increased expression of PPARG protein		 CTD PMID:16052515 PMID:19247274 PMID:19522023 PMID:23943857 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Celecoxib promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:19293639 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Celecoxib results in increased expression of PTGDS protein CTD PMID:23943857 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO Celecoxib inhibits the reaction [PTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene] CTD PMID:21739481 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions EXP Celecoxib inhibits the reaction [Heymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA] CTD PMID:14636300 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions EXP [Celecoxib co-treated with Heymann Nephritis Antigenic Complex] affects the expression of PTGER4 mRNA CTD PMID:14636300 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression		 ISO
EXP		 [Celecoxib co-treated with docetaxel] results in decreased expression of PTGES protein
Celecoxib results in decreased expression of PTGES mRNA		 CTD PMID:16052515 PMID:16273290 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression		 ISO
EXP		 Celecoxib analog results in decreased activity of PTGS1 protein; Celecoxib results in decreased activity of PTGS1 protein
Celecoxib results in decreased expression of PTGS1 mRNA alternative form		 CTD PMID:11375891 PMID:16141368 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
decreases activity
increases expression
increases response to substance
affects binding		 ISO
EXP		 Celecoxib analog results in decreased expression of PTGS2 protein; Celecoxib results in decreased expression of PTGS2; Celecoxib results in decreased expression of PTGS2 mRNA; Celecoxib results in decreased expression of PTGS2 protein
[Celecoxib analog results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [FEC protocol co-treated with Celecoxib] results in decreased expression of PTGS2 protein; [tetraarsenic tetrasulfide co-treated with Celecoxib] results in decreased expression of PTGS2 protein; Celecoxib binds to and results in decreased activity of PTGS2 protein; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Quercetin results in decreased expression of PTGS2 protein]; Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein; Celecoxib results in increased expression of and results in increased activity of PTGS2 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib results in increased activity of PTGS2 protein]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]
Celecoxib analog results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein mutant form
Celecoxib results in increased expression of PTGS2 mRNA; Celecoxib results in increased expression of PTGS2 protein
PTGS2 results in increased susceptibility to Celecoxib
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane A2; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Mustard Gas; [Celecoxib results in decreased activity of PTGS2 protein] which results in increased susceptibility to Acetaminophen; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [potassium superoxide results in increased expression of PTGS2 mRNA]; Celecoxib results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein alternative form
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; Celecoxib inhibits the reaction [BQ 788 results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
Celecoxib binds to PTGS2 protein		 CTD PMID:11743745 PMID:12417326 PMID:12727271 PMID:12888902 PMID:12967936 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pxk PX domain containing serine/threonine kinase like affects expression ISO Celecoxib affects the expression of PXK mRNA CTD PMID:20562220 NCBI chr15:16,759,857...16,828,452
Ensembl chr15:16,759,862...16,828,444 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 ISO [Atorvastatin co-treated with Celecoxib] results in decreased expression of RB1 protein modified form; [Atorvastatin co-treated with Celecoxib] results in increased expression of RB1 protein
Celecoxib results in increased expression of RB1		 CTD PMID:18172863 PMID:19846907 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO
EXP		 [irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; Celecoxib inhibits the reaction [Doxorubicin affects the localization of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]
Celecoxib results in decreased expression of RELA protein
Celecoxib inhibits the reaction [Gentamicins results in increased expression of RELA protein]		 CTD PMID:15489888 PMID:15570007 PMID:16685529 PMID:17097285 PMID:19635192 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin decreases expression EXP Celecoxib results in decreased expression of REN protein CTD PMID:10742298 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein] CTD PMID:18172863 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased localization of RHOB protein; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOB protein] CTD PMID:18172863 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOC protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOC protein] CTD PMID:18172863 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Celecoxib affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor affects expression ISO Celecoxib affects the expression of SARAF mRNA CTD PMID:20562220 NCBI chr16:58,017,231...58,035,481
Ensembl chr16:58,017,231...58,035,545 		JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component affects expression ISO Celecoxib affects the expression of SEC23A mRNA CTD PMID:20562220 NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035 		JBrowse link
G Sele selectin E multiple interactions ISO Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]] CTD PMID:14762100 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA] CTD PMID:16420518 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Si sucrase-isomaltase increases activity EXP Celecoxib results in increased activity of SI protein CTD PMID:18604318 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC16A3 mRNA] CTD PMID:27452194 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression		 ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC2A1 mRNA]
Celecoxib results in increased expression of SLC2A1 mRNA		 CTD PMID:19327236 PMID:27452194 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
affects expression
decreases expression		 ISO [Celecoxib results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin
Celecoxib affects the expression of SLC31A1 mRNA		 CTD PMID:20562220 PMID:21177414 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Celecoxib results in increased expression of SLC3A2 mRNA CTD PMID:33785417 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Celecoxib results in increased expression of SLC7A11 mRNA CTD PMID:33785417 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization
multiple interactions		 ISO Celecoxib affects the localization of SNAI1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]		 CTD PMID:29932878 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Celecoxib results in decreased expression of SOD2 protein CTD PMID:18848576 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] CTD PMID:29396848 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Celecoxib co-treated with ABT-737] results in decreased expression of SQSTM1 protein CTD PMID:20104024 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Celecoxib results in increased expression of SSTR2 protein CTD PMID:17959037 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein CTD PMID:21268125 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Celecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
affects activity		 ISO Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]
Celecoxib affects the activity of SULT2A1 protein		 CTD PMID:15483193 PMID:17239972 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tfeb transcription factor EB increases expression
multiple interactions		 ISO Celecoxib results in increased expression of TFEB mRNA
[Celecoxib co-treated with Paraquat] results in increased expression of TFEB mRNA; [Oxidopamine co-treated with Celecoxib] results in increased expression of TFEB mRNA; Celecoxib inhibits the reaction [Paraquat results in increased expression of TFEB mRNA]; Oxidopamine promotes the reaction [Celecoxib results in increased expression of TFEB mRNA]		 CTD PMID:33160981 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of TGFB1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Celecoxib results in decreased expression of TGFB1 mRNA		 CTD PMID:19194550 PMID:19201774 PMID:24462674 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA CTD PMID:16420518 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tm9sf4 transmembrane 9 superfamily member 4 affects expression ISO Celecoxib affects the expression of TM9SF4 mRNA CTD PMID:20562220 NCBI chr 3:141,627,128...141,675,386
Ensembl chr 3:141,627,346...141,675,386 		JBrowse link
G Tmem131 transmembrane protein 131 affects expression ISO Celecoxib affects the expression of TMEM131 mRNA CTD PMID:20562220 NCBI chr 9:39,016,470...39,162,841
Ensembl chr 9:39,016,485...39,162,964 		JBrowse link
G Tmx2 thioredoxin-related transmembrane protein 2 affects expression ISO Celecoxib affects the expression of TMX2 mRNA CTD PMID:20562220 NCBI chr 3:69,754,937...69,762,587
Ensembl chr 3:69,754,939...69,762,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of TNF; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of TNF protein]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of TNF protein]
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of TNF protein]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Celecoxib results in decreased expression of TNF protein		 CTD PMID:15489888 PMID:16230411 PMID:16702388 PMID:17908994 PMID:19247274 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Celecoxib results in increased expression of TNFRSF10A mRNA; Celecoxib results in increased expression of TNFRSF10A protein CTD PMID:15572759 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases secretion
increases expression		 ISO Celecoxib results in decreased secretion of TNFRSF11B protein
Celecoxib results in increased expression of TNFRSF11B mRNA		 CTD PMID:19327236 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein] CTD PMID:15572759 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
increases response to substance		 ISO
EXP		 Celecoxib results in increased expression of TP53 mRNA; Celecoxib results in increased expression of TP53 protein
[FEC protocol co-treated with Celecoxib] results in decreased expression of TP53 protein; Celecoxib results in increased activity of and results in increased localization of TP53 protein; Celecoxib results in increased expression of and results in increased phosphorylation of TP53 protein; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]
[Celecoxib co-treated with docetaxel] results in increased expression of TRP53 protein; Celecoxib promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]
Celecoxib inhibits the reaction [Gentamicins results in increased expression of TP53 protein]		 CTD PMID:15458769 PMID:16052515 PMID:16507397 PMID:18202791 PMID:18760266 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vapb VAMP associated protein B and C affects expression ISO Celecoxib affects the expression of VAPB mRNA CTD PMID:20562220 NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases expression
affects expression
multiple interactions		 ISO
EXP		 Celecoxib results in decreased expression of VEGFA; Celecoxib results in decreased expression of VEGFA protein
Celecoxib results in increased expression of VEGFA mRNA; Celecoxib results in increased expression of VEGFA protein
Celecoxib affects the expression of VEGFA mRNA
[Celecoxib co-treated with docetaxel] results in decreased expression of VEGFA protein; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of VEGFA protein]
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]
Celecoxib results in decreased expression of VEGFA mRNA; Celecoxib results in decreased expression of VEGFA protein		 CTD PMID:15126378 PMID:16052515 PMID:16230411 PMID:17201140 PMID:17224647 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        anti-inflammatory agent 16684
          anti-inflammatory drug 14974
            non-steroidal anti-inflammatory drug 14290
              celecoxib 221
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  heteroarene 17169
                                    monocyclic heteroarene 14995
                                      azole 14515
                                        diazole 10781
                                          pyrazoles 2332
                                            celecoxib 221
paths to the root