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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:doramapimod
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Accession:CHEBI:40953 term browser browse the term
Definition:A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
Synonyms:related_synonym: 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea;   1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;   BIRB 796;   N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
 alt_id: MESH:C452139
 xref: CAS:285983-48-4
 xref_mesh: MESH:C452139
 xref: Reaxys:9170597;   kegg.drug:D03736;   lincs.smallmolecule:LSM-1170;   pdb-ccd:B96;   pubmed:11896401;   pubmed:19244237;   pubmed:20655210;   pubmed:23685672;   pubmed:25358442;   pubmed:25589935;   pubmed:26044359;   pubmed:26232862
 chemrof_formula: C31H37N5O3
 chemrof_smiles: Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1
 chemrof_inchi: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
 chemrof_inchikey: MVCOAUNKQVWQHZ-UHFFFAOYSA-N


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doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO doramapimod results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression EXP doramapimod results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP doramapimod results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:229,421,252...229,436,691 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO doramapimod results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039 		JBrowse link
G Ak5 adenylate kinase 5 increases expression EXP doramapimod results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:244,057,240...244,241,366 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO doramapimod results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO doramapimod results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G C1qa complement C1q A chain decreases expression ISO doramapimod results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732 		JBrowse link
G C1qb complement C1q B chain decreases expression ISO doramapimod results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression ISO doramapimod results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:28629242 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cd5l Cd5 molecule-like decreases expression ISO doramapimod results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:175,088,884...175,099,926 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO doramapimod results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP doramapimod results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798 		JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO doramapimod results in increased expression of CES3 mRNA CTD PMID:21328587 NCBI chr19:49,902,312...49,910,484 JBrowse link
G Clec1b C-type lectin domain family 1, member B decreases expression ISO doramapimod results in decreased expression of CLEC1B mRNA CTD PMID:21328587 NCBI chr 4:164,533,987...164,542,320
Ensembl chr 4:164,534,055...164,542,867 		JBrowse link
G Ctss cathepsin S decreases expression ISO doramapimod results in decreased expression of CTSS mRNA CTD PMID:21328587 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO doramapimod results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein] CTD PMID:14997032 NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:14997032 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO doramapimod results in increased expression of CYP2A4 mRNA CTD PMID:21328587 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649 		JBrowse link
G Cyss cystatin S decreases expression EXP doramapimod results in decreased expression of CYSS mRNA CTD PMID:24303162 NCBI chr 3:157,892,660...157,897,265
Ensembl chr 3:157,892,660...157,897,265 		JBrowse link
G Egr1 early growth response 1 increases expression ISO doramapimod results in increased expression of EGR1 mRNA CTD PMID:21328587 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO doramapimod results in decreased expression of FCGR2B mRNA CTD PMID:21328587 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517 		JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP doramapimod results in decreased expression of FGF8 mRNA CTD PMID:24303162 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:254,533,504...254,539,605 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO doramapimod results in decreased expression of G6PC1 mRNA CTD PMID:21328587 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO doramapimod results in increased expression of GCLC mRNA CTD PMID:21328587 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO doramapimod results in increased expression of GPX2 mRNA CTD PMID:21328587 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression EXP doramapimod results in increased expression of GRM8 mRNA CTD PMID:24303162 NCBI chr 4:56,771,247...57,696,951
Ensembl chr 4:56,770,771...57,687,639 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO doramapimod results in increased expression of GSTA1 mRNA CTD PMID:21328587 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO doramapimod results in increased expression of GSTM2 mRNA CTD PMID:21328587 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO doramapimod results in increased expression of GSTM3 mRNA CTD PMID:21328587 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Hp haptoglobin decreases expression ISO doramapimod results in decreased expression of HP mRNA CTD PMID:21328587 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP doramapimod results in decreased expression of HPD mRNA CTD PMID:24303162 NCBI chr12:39,042,246...39,053,596
Ensembl chr12:39,042,238...39,053,612 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO doramapimod inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein] CTD PMID:19427879 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28629242 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP doramapimod results in decreased expression of KCNK1 mRNA CTD PMID:24303162 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051 		JBrowse link
G Lmod1 leiomodin 1 increases expression EXP doramapimod results in increased expression of LMOD1 mRNA CTD PMID:24303162 NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases activity ISO doramapimod results in decreased activity of MAPK14 protein CTD PMID:28629242 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Meig1 meiosis/spermiogenesis associated 1 increases expression ISO doramapimod results in increased expression of MEIG1 mRNA CTD PMID:21328587 NCBI chr17:79,718,630...79,737,604
Ensembl chr17:79,723,811...79,737,533 		JBrowse link
G Mt1a metallothionein 1A increases expression ISO doramapimod results in increased expression of MT1 mRNA CTD PMID:21328587 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mybpc1 myosin binding protein C1 decreases expression EXP doramapimod results in decreased expression of MYBPC1 mRNA CTD PMID:24303162 NCBI chr 7:24,817,770...24,903,681
Ensembl chr 7:24,817,561...24,903,544 		JBrowse link
G Myh11 myosin heavy chain 11 increases expression EXP doramapimod results in increased expression of MYH11 mRNA CTD PMID:24303162 NCBI chr10:1,250,554...1,345,681
Ensembl chr10:1,263,194...1,345,678 		JBrowse link
G Myh3 myosin heavy chain 3 increases expression EXP doramapimod results in increased expression of MYH3 mRNA CTD PMID:24303162 NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO doramapimod results in increased expression of NQO1 mRNA CTD PMID:21328587 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP doramapimod results in increased expression of OLR59 mRNA CTD PMID:24303162 NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:166,604,141...166,623,265 		JBrowse link
G Otog otogelin decreases expression EXP doramapimod results in decreased expression of OTOG mRNA CTD PMID:24303162 NCBI chr 1:105,882,747...105,951,825
Ensembl chr 1:105,882,747...105,951,824 		JBrowse link
G Pfn2 profilin 2 increases expression ISO doramapimod results in increased expression of PFN2 mRNA CTD PMID:21328587 NCBI chr 2:144,217,100...144,222,936
Ensembl chr 2:144,205,636...144,222,936 		JBrowse link
G Pon1 paraoxonase 1 decreases expression EXP doramapimod results in decreased expression of PON1 mRNA CTD PMID:24303162 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO doramapimod results in increased expression of PPARG mRNA CTD PMID:21328587 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prm2 protamine 2 increases expression ISO doramapimod results in increased expression of PRM2 mRNA CTD PMID:21328587 NCBI chr10:5,383,208...5,383,949
Ensembl chr10:5,379,029...5,384,004 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP doramapimod results in increased expression of RGS4 mRNA CTD PMID:24303162 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO doramapimod results in decreased expression of H2-AB1 mRNA CTD PMID:21328587 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO doramapimod results in increased expression of SLC7A11 mRNA CTD PMID:21328587 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 decreases expression EXP doramapimod results in decreased expression of SPOCK2 mRNA CTD PMID:24303162 NCBI chr20:28,580,262...28,607,198
Ensembl chr20:28,580,226...28,608,409 		JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 decreases expression ISO doramapimod results in decreased expression of SPSB1 mRNA CTD PMID:21328587 NCBI chr 5:165,641,255...165,701,482
Ensembl chr 5:165,642,851...165,654,225 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO doramapimod results in increased expression of SRXN1 mRNA CTD PMID:21328587 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
G Stmn2 stathmin 2 increases expression EXP doramapimod results in increased expression of STMN2 mRNA CTD PMID:24303162 NCBI chr 2:95,112,017...95,159,642
Ensembl chr 2:95,112,019...95,159,335 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein]
doramapimod inhibits the reaction [nivalenol results in increased secretion of TNF protein] 		CTD PMID:28629242 PMID:38616237 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 decreases expression ISO doramapimod results in decreased expression of VSIG4 mRNA CTD PMID:21328587 NCBI chr  X:65,154,422...65,179,708
Ensembl chr  X:65,154,424...65,179,708 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        immunomodulator 15087
          doramapimod 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  heteroarene 17357
                                    monocyclic heteroarene 15176
                                      azole 14629
                                        diazole 10862
                                          pyrazoles 2369
                                            doramapimod 63
paths to the root