CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: doramapimod
Accession: CHEBI:40953
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Definition: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
Synonyms: exact_synonym: N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
related_synonym: 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea; 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea; BIRB 796; Formula=C31H37N5O3; InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37); InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N; SMILES=C(=O)(NC=1N(N=C(C1)C(C)(C)C)C=2C=CC(=CC2)C)NC=3C4=C(C=CC=C4)C(=CC3)OCCN5CCOCC5
alt_id: MESH:C452139
xref: CAS:285983-48-4; KEGG:D03736; LINCS:LSM-1170
xref_mesh: MESH:C452139
xref: PDBeChem:B96; PMID:11896401; PMID:19244237; PMID:20655210; PMID:23685672; PMID:25358442; PMID:25589935; PMID:26044359; PMID:26232862; Reaxys:9170597
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
doramapimod results in increased expression of ABCC2 mRNA
CTD
PMID:21328587
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Actg2
actin gamma 2, smooth muscle
increases expression
EXP
doramapimod results in increased expression of ACTG2 mRNA
CTD
PMID:24303162
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
increases expression
EXP
doramapimod results in increased expression of ADH7 mRNA
CTD
PMID:24303162
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
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Ahsg
alpha-2-HS-glycoprotein
decreases expression
ISO
doramapimod results in decreased expression of AHSG mRNA
CTD
PMID:21328587
NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
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Ak5
adenylate kinase 5
increases expression
EXP
doramapimod results in increased expression of AK5 mRNA
CTD
PMID:24303162
NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
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Akr1b7
aldo-keto reductase family 1, member B7
increases expression
ISO
doramapimod results in increased expression of AKR1B7 mRNA
CTD
PMID:21328587
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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Apoa4
apolipoprotein A4
decreases expression
ISO
doramapimod results in decreased expression of APOA4 mRNA
CTD
PMID:21328587
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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C1qa
complement C1q A chain
decreases expression
ISO
doramapimod results in decreased expression of C1QA mRNA
CTD
PMID:21328587
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C1qb
complement C1q B chain
decreases expression
ISO
doramapimod results in decreased expression of C1QB mRNA
CTD
PMID:21328587
NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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Car3
carbonic anhydrase 3
decreases expression
ISO
doramapimod results in decreased expression of CAR3 mRNA
CTD
PMID:21328587
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Casp3
caspase 3
multiple interactions
ISO
doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein]
CTD
PMID:28629242
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cd5l
Cd5 molecule-like
decreases expression
ISO
doramapimod results in decreased expression of CD5L mRNA
CTD
PMID:21328587
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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Cd74
CD74 molecule
decreases expression
ISO
doramapimod results in decreased expression of CD74 mRNA
CTD
PMID:21328587
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Ceacam1
CEA cell adhesion molecule 1
decreases expression
EXP
doramapimod results in decreased expression of CEACAM1 mRNA
CTD
PMID:24303162
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Ces3a
carboxylesterase 3a
increases expression
ISO
doramapimod results in increased expression of CES3 mRNA
CTD
PMID:21328587
NCBI chr19:32,992,386...33,000,562
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Clec1b
C-type lectin domain family 1, member B
decreases expression
ISO
doramapimod results in decreased expression of CLEC1B mRNA
CTD
PMID:21328587
NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291
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Ctss
cathepsin S
decreases expression
ISO
doramapimod results in decreased expression of CTSS mRNA
CTD
PMID:21328587
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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Cxcl1
C-X-C motif chemokine ligand 1
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]
CTD
PMID:14997032
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
decreases secretion
ISO
doramapimod results in decreased secretion of CXCL10 protein
CTD
PMID:17996064
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]
CTD
PMID:14997032
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cxcr1
C-X-C motif chemokine receptor 1
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein]
CTD
PMID:14997032
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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Cxcr2
C-X-C motif chemokine receptor 2
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]
CTD
PMID:14997032
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
increases expression
ISO
doramapimod results in increased expression of CYP2A4 mRNA
CTD
PMID:21328587
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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Cyss
cystatin S
decreases expression
EXP
doramapimod results in decreased expression of CYSS mRNA
CTD
PMID:24303162
NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610
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Egr1
early growth response 1
increases expression
ISO
doramapimod results in increased expression of EGR1 mRNA
CTD
PMID:21328587
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Fcgr2b
Fc gamma receptor 2B
decreases expression
ISO
doramapimod results in decreased expression of FCGR2B mRNA
CTD
PMID:21328587
NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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Fgf8
fibroblast growth factor 8
decreases expression
EXP
doramapimod results in decreased expression of FGF8 mRNA
CTD
PMID:24303162
NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
doramapimod results in decreased expression of G6PC1 mRNA
CTD
PMID:21328587
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
doramapimod results in increased expression of GCLC mRNA
CTD
PMID:21328587
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gpx2
glutathione peroxidase 2
increases expression
ISO
doramapimod results in increased expression of GPX2 mRNA
CTD
PMID:21328587
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Grm8
glutamate metabotropic receptor 8
increases expression
EXP
doramapimod results in increased expression of GRM8 mRNA
CTD
PMID:24303162
NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831
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Gsta2
glutathione S-transferase alpha 2
increases expression
ISO
doramapimod results in increased expression of GSTA2 mRNA
CTD
PMID:21328587
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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Gsta5
glutathione S-transferase alpha 5
increases expression
ISO
doramapimod results in increased expression of GSTA1 mRNA
CTD
PMID:21328587
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Gstm2
glutathione S-transferase mu 2
increases expression
ISO
doramapimod results in increased expression of GSTM2 mRNA
CTD
PMID:21328587
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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Gstm5
glutathione S-transferase, mu 5
increases expression
ISO
doramapimod results in increased expression of GSTM3 mRNA
CTD
PMID:21328587
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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Hp
haptoglobin
decreases expression
ISO
doramapimod results in decreased expression of HP mRNA
CTD
PMID:21328587
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Hpd
4-hydroxyphenylpyruvate dioxygenase
decreases expression
EXP
doramapimod results in decreased expression of HPD mRNA
CTD
PMID:24303162
NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
doramapimod inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein]
CTD
PMID:19427879
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il1b
interleukin 1 beta
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD
PMID:28629242
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Kcnk1
potassium two pore domain channel subfamily K member 1
decreases expression
EXP
doramapimod results in decreased expression of KCNK1 mRNA
CTD
PMID:24303162
NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724
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Lmod1
leiomodin 1
increases expression
EXP
doramapimod results in increased expression of LMOD1 mRNA
CTD
PMID:24303162
NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900
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Mapk14
mitogen activated protein kinase 14
decreases activity
ISO
doramapimod results in decreased activity of MAPK14 protein
CTD
PMID:28629242
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Meig1
meiosis/spermiogenesis associated 1
increases expression
ISO
doramapimod results in increased expression of MEIG1 mRNA
CTD
PMID:21328587
NCBI chr17:74,810,791...74,828,433
Ensembl chr17:74,814,632...74,828,433
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Mt1
metallothionein 1
increases expression
ISO
doramapimod results in increased expression of MT1 mRNA
CTD
PMID:21328587
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mybpc1
myosin binding protein C1
decreases expression
EXP
doramapimod results in decreased expression of MYBPC1 mRNA
CTD
PMID:24303162
NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957
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Myh11
myosin heavy chain 11
increases expression
EXP
doramapimod results in increased expression of MYH11 mRNA
CTD
PMID:24303162
NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459
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Myh3
myosin heavy chain 3
increases expression
EXP
doramapimod results in increased expression of MYH3 mRNA
CTD
PMID:24303162
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
doramapimod results in increased expression of NQO1 mRNA
CTD
PMID:21328587
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Olr59
olfactory receptor 59
increases expression
EXP
doramapimod results in increased expression of OLR59 mRNA
CTD
PMID:24303162
NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179
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Otog
otogelin
decreases expression
EXP
doramapimod results in decreased expression of OTOG mRNA
CTD
PMID:24303162
NCBI chr 1:96,746,336...96,815,416
Ensembl chr 1:96,746,336...96,815,415
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Pfn2
profilin 2
increases expression
ISO
doramapimod results in increased expression of PFN2 mRNA
CTD
PMID:21328587
NCBI chr 2:142,067,102...142,072,938
Ensembl chr 2:142,067,104...142,072,938
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Pon1
paraoxonase 1
decreases expression
EXP
doramapimod results in decreased expression of PON1 mRNA
CTD
PMID:24303162
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
doramapimod results in increased expression of PPARG mRNA
CTD
PMID:21328587
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prm2
protamine 2
increases expression
ISO
doramapimod results in increased expression of PRM2 mRNA
CTD
PMID:21328587
NCBI chr10:4,876,285...4,877,026
Ensembl chr10:4,873,372...4,877,026
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Rgs4
regulator of G-protein signaling 4
increases expression
EXP
doramapimod results in increased expression of RGS4 mRNA
CTD
PMID:24303162
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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RT1-Bb
RT1 class II, locus Bb
decreases expression
ISO
doramapimod results in decreased expression of H2-AB1 mRNA
CTD
PMID:21328587
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
doramapimod results in increased expression of SLC7A11 mRNA
CTD
PMID:21328587
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Spock2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
decreases expression
EXP
doramapimod results in decreased expression of SPOCK2 mRNA
CTD
PMID:24303162
NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272
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Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
decreases expression
ISO
doramapimod results in decreased expression of SPSB1 mRNA
CTD
PMID:21328587
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Srxn1
sulfiredoxin 1
increases expression
ISO
doramapimod results in increased expression of SRXN1 mRNA
CTD
PMID:21328587
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Stmn2
stathmin 2
increases expression
EXP
doramapimod results in increased expression of STMN2 mRNA
CTD
PMID:24303162
NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011
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Tnf
tumor necrosis factor
multiple interactions
ISO
doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein]
CTD
PMID:28629242
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vsig4
V-set and immunoglobulin domain containing 4
decreases expression
ISO
doramapimod results in decreased expression of VSIG4 mRNA
CTD
PMID:21328587
NCBI chr X:61,144,926...61,170,212
Ensembl chr X:61,144,928...61,170,212
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