aminoguanidine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	aminoguanidine	go back to main search page
Accession:	CHEBI:40618	browse the term
Definition:	A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Synonyms:	related_synonym:	2-aminoguanidine; 2-azanylguanidine; AG; Formula=CH6N4; Guanyl hydrazine; Imino semicarbazide; InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5); InChIKey=HAMNKKUPIHEESI-UHFFFAOYSA-N; Monoaminoguanidine; SMILES=NNC(N)=N; hydrazinecarboximidamide; pimagedine
	alt_id:	CHEBI:475161
	xref:	Beilstein:741921; CAS:79-17-4; DrugBank:DB02533
	xref_mesh:	MESH:C004479
	xref:	PDBeChem:AGU; PMID:10848923; PMID:11328740; PMID:11812359

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Genes (71)

aminoguanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

advanced glycosylation end product-specific receptor

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]

PMID:26723916 PMID:29148590

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

allograft inflammatory factor 1

multiple interactions

pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

albumin

multiple interactions

pimagedine inhibits the reaction [[Fructose co-treated with Glucose] results in increased glycation of ALB protein]; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]

PMID:12196478 PMID:22287321 PMID:36933777

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

amine oxidase, copper containing 1

multiple interactions
decreases activity

pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine results in decreased activity of AOC1 protein
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]

PMID:6218830 PMID:8144586

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

amyloid beta precursor protein

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

pimagedine results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

beta-secretase 1

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2 associated X, apoptosis regulator

decreases expression

pimagedine results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein

PMID:16980304 PMID:17135264 PMID:17786558

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcitonin-related polypeptide alpha

multiple interactions

pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

multiple interactions

pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]

PMID:15545282 PMID:33930484

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]

PMID:17786558 PMID:19556603 PMID:33930484

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases expression

[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein

PMID:12123627 PMID:19107871 PMID:19266598 PMID:19481068 PMID:22287321

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

pimagedine results in decreased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CD34 molecule

decreases expression

pimagedine results in decreased expression of CD34 protein

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CF transmembrane conductance regulator

multiple interactions

pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

collagen type I alpha 1 chain

increases expression

pimagedine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cAMP responsive element binding protein 1

decreases phosphorylation

pimagedine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

C-X-C motif chemokine receptor 2

multiple interactions

[pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome b-245 alpha chain

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

endothelin 1

multiple interactions

pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

Fc epsilon receptor II

multiple interactions

pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]

NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein]

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

glutamate cysteine ligase, modifier subunit

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glial fibrillary acidic protein

multiple interactions

[7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glyoxalase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]

PMID:26723916 PMID:28919305 PMID:29148590 PMID:33930484

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamic--pyruvic transaminase

multiple interactions

pimagedine inhibits the reaction [sodium arsenite results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase alpha 5

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA]

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]

PMID:29148590 PMID:33930484

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interferon gamma

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]

PMID:7689037 PMID:11498278 PMID:12612912 PMID:12892526 PMID:12911628 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions

pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]

PMID:9698594 PMID:11500085 PMID:12123627 PMID:25406100 PMID:28223158 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]

PMID:25042521 PMID:26723916 PMID:28223158 PMID:29148590

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

decreases expression

pimagedine results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 13

increases expression

pimagedine results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

increases expression

pimagedine results in increased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 9

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein]

PMID:11713966 PMID:18209962

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded cytochrome c oxidase I

affects activity
affects expression

pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

NFE2 like bZIP transcription factor 2

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 1

affects expression

pimagedine affects the expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

decreases expression
decreases activity
multiple interactions
affects expression

pimagedine results in decreased expression of NOS2 protein
pimagedine results in decreased activity of NOS2 protein
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein

PMID:9306416 PMID:9810145 PMID:9853001 PMID:11574821 PMID:12054156 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

affects expression
multiple interactions

pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

plasminogen activator, tissue type

multiple interactions

pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

PPARG coactivator 1 alpha

multiple interactions

[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein

PMID:26723916 PMID:28919305

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

presenilin 1

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

presenilin 2

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

prostaglandin-endoperoxide synthase 2

multiple interactions

pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein

PMID:15067210 PMID:17637181 PMID:29935243

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein B

multiple interactions

pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

serpin family E member 1

multiple interactions
increases expression

pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA

PMID:10856522 PMID:18380797

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sirtuin 1

multiple interactions

[pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 1

decreases expression
multiple interactions

pimagedine results in decreased expression of SOD1 protein
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]

PMID:19266598 PMID:33930484

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein

PMID:18483403 PMID:19266598

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 1

multiple interactions

pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

transforming growth factor, beta 1

increases expression
multiple interactions

pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]

PMID:18380797 PMID:25406100

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

pimagedine results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]

PMID:12123627 PMID:12612912 PMID:22287321 PMID:25042521 PMID:25406100 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA]

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
atom	19872
nonmetal atom	19794
carbon atom	19748
organic molecular entity	19748
one-carbon compound	17863
aminoguanidine	71
mitoguazone	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
p-block molecular entity	19811
carbon group molecular entity	19751
organic molecular entity	19748
heteroorganic entity	19505
organonitrogen compound	18827
guanidines	2344
aminoguanidine	71
mitoguazone	0

paths to the root