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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclophosphamide
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Accession:CHEBI:4027 term browser browse the term
Definition:A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Synonyms:exact_synonym: N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
 related_synonym: (RS)-Cyclophosphamide;   2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide;   Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester;   Cyclophosphamide anhydrous;   Formula=C7H15Cl2N2O2P;   InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12);   InChIKey=CMSMOCZEIVJLDB-UHFFFAOYSA-N;   N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide;   SMILES=ClCCN(CCCl)P1(=O)NCCCO1
 xref: CAS:50-18-0;   DrugBank:DB00531;   Drug_Central:758;   HMDB:HMDB0014672;   KEGG:C07888;   KEGG:D07760;   LINCS:LSM-4961
 xref_mesh: MESH:D003520
 xref: PMID:15711186;   PMID:7850793;   Reaxys:11744;   Wikipedia:Cyclophosphamide


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cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        xenobiotic 40
          cyclophosphamide 1
            cyclophosphamide hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 498
    subatomic particle 498
      composite particle 498
        hadron 498
          baryon 498
            nucleon 498
              atomic nucleus 498
                atom 498
                  main group element atom 491
                    p-block element atom 491
                      chalcogen 447
                        oxygen atom 445
                          oxygen molecular entity 445
                            hydroxides 420
                              oxoacid 375
                                pnictogen oxoacid 14
                                  phosphorus oxoacid 9
                                    phosphoric acids 9
                                      phosphoric acid 9
                                        phosphoramide 1
                                          phosphorodiamide 1
                                            cyclophosphamide 1
                                              cyclophosphamide hydrate 0
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