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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amprenavir
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Accession:CHEBI:40050 term browser browse the term
Definition:A tetrahydrofuryl ester that has formula C25H35N3O6S.
Synonyms:related_synonym: (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate;   (3S)-tetrahydrofuran-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-hydroxypropyl]carbamate;   Agenerase;   Formula=C25H35N3O6S;   InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1;   InChIKey=YMARZQAQMVYCKC-OEMFJLHTSA-N;   SMILES=CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
 alt_id: CHEBI:2684;   CHEBI:40043
 xref: Beilstein:10126027;   CAS:161814-49-9;   DrugBank:DB00701;   Drug_Central:200;   KEGG:C08086;   KEGG:D00894
 xref_mesh: MESH:C095108
 xref: Wikipedia:Amprenavir


show annotations for term's descendants           Sort by:
amprenavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO amprenavir results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects binding
multiple interactions 		ISO ABCB1 protein results in increased transport of amprenavir
amprenavir binds to ABCB1 protein
[Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of amprenavir 		CTD PMID:23976943 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO amprenavir results in increased expression of CCL2 protein CTD PMID:17668557 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO amprenavir results in increased expression of CCL3 protein CTD PMID:17668557 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO amprenavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of amprenavir] CTD PMID:18799805 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          antiviral agent 11451
            antiviral drug 2030
              amprenavir 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      chalcogen 20489
                        oxygen atom 20455
                          oxygen molecular entity 20455
                            hydroxides 20228
                              oxoacid 19285
                                chalcogen oxoacid 13893
                                  sulfur oxoacid 13684
                                    sulfonic acid 11712
                                      sulfonic acid derivative 11712
                                        sulfonamide 5380
                                          amprenavir 6
paths to the root