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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:12-hydroxylauric acid
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Accession:CHEBI:39567 term browser browse the term
Definition:A medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid.
Synonyms:related_synonym: 12-Hydroxydodecanoic acid;   12-hydroxy lauric acid;   2-hydroxy-dodecanoic acid;   Formula=C12H24O3;   InChI=1S/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15);   InChIKey=ZDHCZVWCTKTBRY-UHFFFAOYSA-N;   SMILES=OCCCCCCCCCCCC(O)=O;   omega-OH dodecanoic acid;   omega-OH lauric acid;   omega-hydroxy lauric acid;   omega-hydroxydodecanoic acid
 alt_id: CHEBI:10616;   CHEBI:39557
 xref: Beilstein:1238370;   CAS:505-95-3;   DrugBank:DB03704;   HMDB:HMDB0002059;   KEGG:C08317;   KNApSAcK:C00001219;   LIPID_MAPS_instance:LMFA01050039
 xref_mesh: MESH:C031263
 xref: PDBeChem:12H;   PMID:113393;   PMID:16719385;   PMID:2155662;   PMID:7872779;   Reaxys:1238370
 cyclic_relationship: is_conjugate_acid_of CHEBI:36204


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12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
affects binding 		ISO ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid
12-hydroxydodecanoic acid binds to ADH5 protein 		CTD PMID:12196016 PMID:12604204 PMID:19428350 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis 		ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:53,650,978...53,675,916
Ensembl chr16:53,650,569...53,676,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antibacterial agent 16665
            dodecanoic acid 201
              12-hydroxylauric acid 2
                (3R)-3,12-dihydroxylauric acid + 0
                oscr#20 + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      monocarboxylic acid 18309
                                        fatty acid 17010
                                          hydroxy fatty acid 212
                                            omega-hydroxy fatty acid 22
                                              omega-hydroxy-medium-chain fatty acid 22
                                                12-hydroxylauric acid 2
                                                  (3R)-3,12-dihydroxylauric acid + 0
                                                  oscr#20 + 0
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