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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:12-hydroxylauric acid
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Accession:CHEBI:39567 term browser browse the term
Definition:A medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid.
Synonyms:related_synonym: 12-Hydroxydodecanoic acid;   12-hydroxy lauric acid;   2-hydroxy-dodecanoic acid;   Formula=C12H24O3;   InChI=1S/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15);   InChIKey=ZDHCZVWCTKTBRY-UHFFFAOYSA-N;   SMILES=OCCCCCCCCCCCC(O)=O;   omega-OH dodecanoic acid;   omega-OH lauric acid;   omega-hydroxy lauric acid;   omega-hydroxydodecanoic acid
 alt_id: CHEBI:10616;   CHEBI:39557
 xref: Beilstein:1238370;   CAS:505-95-3;   DrugBank:DB03704;   HMDB:HMDB0002059;   KEGG:C08317;   KNApSAcK:C00001219;   LIPID_MAPS_instance:LMFA01050039
 xref_mesh: MESH:C031263
 xref: PDBeChem:12H;   PMID:113393;   PMID:16719385;   PMID:2155662;   PMID:7872779;   Reaxys:1238370
 cyclic_relationship: is_conjugate_acid_of CHEBI:36204


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12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
affects binding		 ISO ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid
12-hydroxydodecanoic acid binds to ADH5 protein		 CTD PMID:12196016 PMID:12604204 PMID:19428350 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        antimicrobial agent 18270
          antibacterial agent 16371
            dodecanoic acid 200
              12-hydroxylauric acid 2
                (3R)-3,12-dihydroxylauric acid + 0
                oscr#20 + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      monocarboxylic acid 18007
                                        fatty acid 16847
                                          hydroxy fatty acid 211
                                            omega-hydroxy fatty acid 22
                                              omega-hydroxy-medium-chain fatty acid 22
                                                12-hydroxylauric acid 2
                                                  (3R)-3,12-dihydroxylauric acid + 0
                                                  oscr#20 + 0
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