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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluorescent probe
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Accession:CHEBI:39442 term browser browse the term
Definition:A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy.


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8-anilinonaphthalene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor affects binding ISO 1-anilino-8-naphthalenesulfonate binds to AMBP protein CTD PMID:16461020 NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850 		JBrowse link
G Apod apolipoprotein D affects binding ISO 1-anilino-8-naphthalenesulfonate binds to APOD protein CTD PMID:16461020 NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263 		JBrowse link
G C8g complement C8 gamma chain affects binding ISO 1-anilino-8-naphthalenesulfonate binds to C8G protein CTD PMID:16461020 NCBI chr 3:28,718,648...28,720,232 JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to GSTA1 protein CTD PMID:14690442 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Lcn1 lipocalin 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN1 protein CTD PMID:16461020 NCBI chr 3:29,930,943...29,935,418 JBrowse link
G Lcn2 lipocalin 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN2 protein CTD PMID:16461020 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Obp2a odorant binding protein 2A affects binding ISO 1-anilino-8-naphthalenesulfonate binds to OBP2A protein CTD PMID:16461020 NCBI chr 3:28,904,024...28,907,391
Ensembl chr 3:28,902,876...28,907,389 		JBrowse link
G Orm1 orosomucoid 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to ORM1 protein CTD PMID:16461020 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Paep progestagen associated endometrial protein affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PAEP protein CTD PMID:16461020 NCBI chr 3:28,929,252...28,932,592 JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978 		JBrowse link
G Ttr transthyretin affects binding
multiple interactions 		ISO 1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein] 		CTD PMID:23584369 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969 		JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Chlortetracycline results in decreased activity of CAT protein CTD PMID:30768968 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
filipin III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP 		Filipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] 		CTD PMID:12614848 PMID:17172471 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein] CTD PMID:20036696 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:29724254 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA] CTD PMID:29724254 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Des desmin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein] CTD PMID:19632255 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein] CTD PMID:17172471 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein] CTD PMID:20036696 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:70,993,622...71,011,585
Ensembl chr13:70,999,186...71,011,572 		JBrowse link
G Prnp prion protein increases secretion
multiple interactions
decreases expression 		ISO Filipin results in increased secretion of PRNP protein
Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]
[Copper co-treated with Filipin] results in increased cleavage of PRNP protein; Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]
Filipin results in decreased expression of PRNP protein alternative form 		CTD PMID:11994310 PMID:19597535 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein] CTD PMID:19632255 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:73,361,296...73,502,464
Ensembl chr  X:73,361,310...73,502,547 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:120,741,750...120,798,513 		JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:28,525,912...29,062,344
Ensembl chr  X:28,525,917...29,061,244 		JBrowse link
G Azi2 5-azacytidine induced 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:126,651,206...126,676,182 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 5:156,718,619...156,818,623
Ensembl chr 5:156,650,432...156,818,619 		JBrowse link
G Cd109 CD109 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 8:88,334,736...88,449,463
Ensembl chr 8:88,334,736...88,449,462 		JBrowse link
G Cd180 CD180 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr 2:35,589,889...35,602,837
Ensembl chr 2:35,589,451...35,603,982 		JBrowse link
G Cd86 CD86 molecule increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cd93 CD93 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 3:156,345,019...156,351,537
Ensembl chr 3:156,345,019...156,351,537 		JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799 		JBrowse link
G Copa COPI coat complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr13:87,078,853...87,119,256
Ensembl chr13:87,078,383...87,119,256 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr 6:108,885,970...108,912,116
Ensembl chr 6:108,885,932...108,912,110 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr 7:9,569,439...9,607,095
Ensembl chr 7:9,569,439...9,607,095 		JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:69,596,475...69,617,206
Ensembl chr18:69,598,827...69,616,175 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760 		JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:148,439,354...148,461,650 		JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein 		CTD PMID:27871981 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression 		ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in decreased expression of IFNG protein] CTD PMID:27863430 PMID:29198882 PMID:36870414 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr 7:1,643,379...1,687,524
Ensembl chr 7:1,644,799...1,687,094 		JBrowse link
G Il13 interleukin 13 multiple interactions
increases expression 		ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL13 protein]]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL13 protein] CTD PMID:28240277 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein CTD PMID:36870414 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 4:148,160,384...148,173,830
Ensembl chr 4:148,159,475...148,173,827 		JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr 2:45,851,073...45,922,300
Ensembl chr 2:45,855,868...45,917,009 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression 		ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein] CTD PMID:27863430 PMID:27871981 PMID:29198882 PMID:36870414 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 increases expression
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased expression of IL5 protein
diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL5 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL5 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL5 protein] 		CTD PMID:27863430 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL6 protein]]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL6 protein] CTD PMID:28240277 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 1:89,354,354...89,358,806
Ensembl chr 1:89,354,335...89,358,810 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] 		CTD PMID:27129696 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] 		CTD PMID:27129696 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein 		CTD PMID:27129696 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation 		ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein 		CTD PMID:27129696 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mt2 metallothionein 2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mybpc1 myosin binding protein C1 affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr 7:24,817,770...24,903,681
Ensembl chr 7:24,817,561...24,903,544 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]] 		CTD PMID:20491607 PMID:27871981 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828 		JBrowse link
G Postn periostin affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300 		JBrowse link
G Pprc1 PPARG related coactivator 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr 1:254,851,136...254,867,570
Ensembl chr 1:254,851,164...254,867,570 		JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 3:27,535,341...27,571,850
Ensembl chr 3:27,535,440...27,573,731 		JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation 		ISO [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide co-treated with diisononyl phthalate] promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of RELA protein]; [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of RELA protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of RELA protein] CTD PMID:27863430 PMID:27871981 PMID:28240277 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 8:72,494,554...72,505,127
Ensembl chr 8:72,494,566...72,503,460 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
increases uptake 		ISO Taurocholic Acid promotes the reaction [SLC10A1 protein results in increased uptake of Fluorescein-5-isothiocyanate] CTD PMID:32209977 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr10:105,885,250...105,935,043
Ensembl chr10:105,885,250...105,935,043 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation 		ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein] CTD PMID:27863430 PMID:27871981 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
increases phosphorylation 		ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein] CTD PMID:27863430 PMID:27871981 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] 		CTD PMID:27863430 PMID:27871981 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Tpsab1 tryptase alpha/beta 1 multiple interactions
increases expression 		ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TPSAB1 protein]]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TPSAB1 protein] CTD PMID:28240277 NCBI chr10:14,864,887...14,867,302
Ensembl chr10:14,864,887...14,867,302 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding
increases expression
multiple interactions 		ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein
Fluorescein-5-isothiocyanate results in increased expression of TRPA1 mRNA; Fluorescein-5-isothiocyanate results in increased expression of TRPA1 protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 mRNA]]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 protein]]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 mRNA]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 mRNA]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TRPA1 protein]] 		CTD PMID:27129696 PMID:28240277 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325 		JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions 		ISO Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide co-treated with diisononyl phthalate] promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [diisononyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein] 		CTD PMID:27863430 PMID:27871981 PMID:28240277 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 8:75,973,278...76,049,151
Ensembl chr 8:75,974,615...76,049,153 		JBrowse link
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal affects expression
multiple interactions 		ISO pyrene affects the expression of ACP2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein 		CTD PMID:28803881 NCBI chr 3:97,630,654...97,642,601
Ensembl chr 3:97,631,326...97,642,565 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects response to substance
affects binding 		EXP
ISO 		pyrene binds to and results in increased activity of AHR protein; pyrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [pyrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; fluoranthene promotes the reaction [pyrene results in increased activity of AHR protein]; pyrene promotes the reaction [fluoranthene results in increased activity of AHR protein]
AHR affects the susceptibility to pyrene
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA; [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA; [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of AHR mRNA; AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]
pyrene binds to AHR protein 		CTD PMID:3024361 PMID:12850102 PMID:17618724 PMID:17665671 PMID:28710019 More... NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019 PMID:30980910 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases expression ISO pyrene results in decreased expression of ALDH3A1 mRNA CTD PMID:32890658 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151 		JBrowse link
G Ar androgen receptor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; pyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; pyrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:26022396 PMID:30980910 PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression 		ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
pyrene affects the expression of BAX protein 		CTD PMID:28803881 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity 		EXP
ISO 		pyrene results in increased expression of CASP3 mRNA
pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]
pyrene results in increased activity of CASP3 protein
pyrene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein 		CTD PMID:19815060 PMID:28803881 PMID:31368503 PMID:35908932 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity EXP pyrene results in increased activity of CASP7 protein CTD PMID:31368503 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression 		ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
pyrene results in decreased expression of CCNA2 protein 		CTD PMID:28803881 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
pyrene results in increased expression of CCND1 protein 		CTD PMID:28803881 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd63 Cd63 molecule decreases expression EXP pyrene results in decreased expression of CD63 protein CTD PMID:31368503 NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938 		JBrowse link
G Cd81 Cd81 molecule decreases expression EXP pyrene results in decreased expression of CD81 protein CTD PMID:31368503 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:207,664,885...207,681,092 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression 		ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
pyrene results in increased expression of CDK2 protein 		CTD PMID:28803881 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects expression 		ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
pyrene affects the expression of CYP19A1 protein 		CTD PMID:28803881 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
increases activity
increases hydroxylation 		ISO
EXP 		[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of CYP1A1 mRNA; [fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
pyrene results in decreased expression of CYP1A1 mRNA
pyrene results in increased expression of CYP1A1 mRNA; pyrene results in increased expression of CYP1A1 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA
pyrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of pyrene 		CTD PMID:7750161 PMID:15016593 PMID:15566942 PMID:16906435 PMID:25956473 More... NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases expression
multiple interactions 		ISO
EXP 		CYP1A2 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1A2 mRNA
pyrene results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of CYP1A2 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of and results in increased activity of CYP1A2 protein 		CTD PMID:7750161 PMID:15016593 PMID:17618724 PMID:26160115 PMID:30240548 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
multiple interactions
decreases expression
increases expression 		ISO CYP1B1 protein results in increased hydroxylation of pyrene
pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]
pyrene results in decreased expression of CYP1B1 mRNA
pyrene results in increased expression of CYP1B1 protein
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] 		CTD PMID:15016593 PMID:15566942 PMID:19365803 PMID:19563207 PMID:30248327 More... NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP pyrene results in increased expression of CYP2B1 mRNA CTD PMID:30240548 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pyrene results in increased expression of CYP2B2 mRNA CTD PMID:30240548 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions 		ISO pyrene results in increased expression of CYP2B6 mRNA
pyrene results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]
[fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with fluoranthene] results in increased expression of CYP2B6 mRNA; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA] 		CTD PMID:17618724 PMID:26160115 PMID:33249052 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP pyrene affects the expression of CYP2C11 mRNA CTD PMID:30240548 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects expression EXP pyrene affects the expression of CYP2C6 mRNA CTD PMID:30240548 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP pyrene results in decreased expression of CYP2E1 mRNA CTD PMID:30240548 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP pyrene results in increased expression of CYP3A23-3A1 mRNA CTD PMID:30240548 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; pyrene binds to and results in increased activity of ESR1 protein CTD PMID:30980910 PMID:33049310 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO pyrene binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP pyrene results in decreased expression of GJB1 protein CTD PMID:25268939 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:70,541,862...70,549,843 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression ISO pyrene results in decreased expression of GSTA1 mRNA CTD PMID:32890658 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression 		ISO [Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of GSTM1 protein
pyrene results in increased expression of GSTM1 mRNA 		CTD PMID:25956473 PMID:26160115 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO pyrene results in increased expression of GSTM3 mRNA CTD PMID:26160115 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrene results in increased expression of HSPA1A mRNA CTD PMID:22367790 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions 		ISO pyrene results in increased expression of ICAM1 protein
[phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ICAM1 mRNA; [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ICAM1 protein 		CTD PMID:22313677 PMID:37888695 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma affects activity
multiple interactions 		ISO pyrene affects the activity of IFNG protein
[phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of IFNG protein 		CTD PMID:9258441 PMID:37888695 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of IL1B protein CTD PMID:37888695 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 increases expression ISO pyrene results in increased expression of IL4 mRNA; pyrene results in increased expression of IL4 protein CTD PMID:10756232 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of IL6 protein CTD PMID:37888695 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFE2L2 mRNA CTD PMID:37888695 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP pyrene results in increased activity of NQO1 protein CTD PMID:16906435 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
decreases expression
increases activity
increases response to substance 		ISO
EXP 		AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]; NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione]; NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]; pyrene affects the localization of and results in increased activity of NR1I3 protein
pyrene results in decreased expression of NR1I3 mRNA
pyrene results in increased activity of NR1I3 protein
NR1I3 results in increased susceptibility to pyrene
[Benzo(a)pyrene co-treated with fluoranthene] inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; [Benzo(a)pyrene co-treated with pyrene] inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA]; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; fluoranthene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; pyrene inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA] 		CTD PMID:17618724 PMID:26160115 PMID:28927721 PMID:30240548 PMID:33249052 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression EXP pyrene results in increased expression of PDCD6IP protein CTD PMID:31368503 NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP pyrene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:33,672,832...33,687,747
Ensembl chr  X:33,674,923...33,687,636 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pyrene binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Docosahexaenoic Acids co-treated with pyrene] results in increased expression of PTGS2 mRNA CTD PMID:25956473 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of RELA mRNA CTD PMID:37888695 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sele selectin E multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of SELE mRNA CTD PMID:37888695 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene CTD PMID:23458896 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [pyrene results in increased expression of CXCL8 mRNA]
[phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of TNF protein 		CTD PMID:18434080 PMID:37888695 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein] CTD PMID:22120587 PMID:35908932 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tsg101 tumor susceptibility 101 increases expression EXP pyrene results in increased expression of TSG101 protein CTD PMID:31368503 NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:106,535,021...106,578,775 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA CTD PMID:17618724 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase family 1 member A6a multiple interactions ISO [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA 		CTD PMID:15566942 PMID:17618724 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of VCAM1 mRNA; [phenanthrene co-treated with fluoranthene co-treated with pyrene] results in increased expression of VCAM1 protein CTD PMID:37888695 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases expression 		ISO 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein 		CTD PMID:22964423 PMID:28263721 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions
increases expression 		ISO 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein 		CTD PMID:22964423 PMID:28263721 PMID:30849339 NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression ISO 7-hydroxycoumarin results in increased expression of AKR7A3 mRNA CTD PMID:28263721 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP 7-hydroxycoumarin results in decreased expression of ATF4 mRNA CTD PMID:34979142 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		7-hydroxycoumarin results in increased expression of BAX protein
7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]; bisphenol A diglycidyl ether inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]] 		CTD PMID:15964220 PMID:34409680 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		7-hydroxycoumarin results in decreased expression of BCL2 protein
7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]; bisphenol A diglycidyl ether inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]] 		CTD PMID:15964220 PMID:34409680 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP
ISO 		7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin results in increased activity of CASP3 protein 		CTD PMID:34979142 PMID:37704181 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 7-hydroxycoumarin results in decreased expression of CCND1 protein CTD PMID:11679177 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions 		EXP 7-hydroxycoumarin results in increased expression of CREB1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CREB1 mRNA] 		CTD PMID:33522649 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cygb cytoglobin multiple interactions
increases expression 		EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CYGB protein]
7-hydroxycoumarin results in increased expression of CYGB protein 		CTD PMID:33522649 NCBI chr10:102,376,506...102,386,272
Ensembl chr10:102,376,507...102,386,272 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarin CTD PMID:34334558 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA] CTD PMID:34979142 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] CTD PMID:33522649 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression 		EXP [7-hydroxycoumarin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA
7-hydroxycoumarin results in increased expression of HSPA5 mRNA 		CTD PMID:34979142 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IKBKB protein] CTD PMID:33522649 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33522649 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:36650709 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:36650709 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 protein] CTD PMID:36650709 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:34979142 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:34979142 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:34979142 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation 		ISO [4-aminobenzhydrazide results in decreased activity of MPO protein] which affects the susceptibility to 7-hydroxycoumarin
MPO protein results in increased oxidation of 7-hydroxycoumarin 		CTD PMID:23994743 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression 		ISO
EXP 		7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 protein
7-hydroxycoumarin results in increased expression of NFE2L2 mRNA; 7-hydroxycoumarin results in increased expression of NFE2L2 protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein] 		CTD PMID:28263721 PMID:33522649 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions 		EXP 7-hydroxycoumarin results in decreased expression of NFKBIA protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein] 		CTD PMID:33522649 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression 		EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]
7-hydroxycoumarin results in increased expression of PPARG mRNA 		CTD PMID:33522649 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:33522649 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions 		EXP 7-hydroxycoumarin results in increased expression of SIRT1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA] 		CTD PMID:33522649 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions 		ISO SLC22A6 protein results in increased uptake of 7-hydroxycoumarin metabolite
7-hydroxycoumarin inhibits the reaction [SLC22A6 protein results in increased uptake of 6-carboxyfluorescein]; 7-hydroxycoumarin metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of 7-hydroxycoumarin metabolite] 		CTD PMID:39481674 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions 		ISO SLC22A8 protein results in increased uptake of 7-hydroxycoumarin metabolite
7-hydroxycoumarin inhibits the reaction [SLC22A8 protein results in increased uptake of 6-carboxyfluorescein]; 7-hydroxycoumarin metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of 7-hydroxycoumarin metabolite] 		CTD PMID:39481674 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:36650709 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP 		SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin CTD PMID:11181495 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:36650709 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:33522649 PMID:36650709 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase family 1 member A6a affects metabolic processing
increases metabolic processing 		EXP UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin 		CTD PMID:9429234 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 7-hydroxycoumarin; UGT1A8 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15044611 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 7-hydroxycoumarin CTD PMID:7574722 NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        probe 247
          fluorescent probe 165
            1-hexadecanoyl-2-\{12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoyl\}-sn-glycero-3-phosphocholine 0
            1-hexadecanoyl-2-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phosphocholine 0
            1-oleoyl-2-\{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phospho-L-serine 0
            2'-MANT-GDP + 0
            2'-MANT-GTP + 0
            3'-MANT-GDP + 0
            3'-MANT-GTP + 0
            4-chloro-7-nitrobenzofurazan 0
            5-[(2-acetamidoethyl)amino]naphthalene-1-sulfonic acid 0
            5-\{[2-(iodoacetamido)ethyl]amino\}naphthalene-1-sulfonic acid 0
            6-O-(carboxymethyl)fluorescein ethyl ester 0
            7-glycidyloxy-9-(2-glycidyloxycarbonylphenyl)-2-xanthone 0
            8-anilinonaphthalene-1-sulfonic acid 11
            FFN206 0
            MANT-GDP 0
            MANT-GTP 0
            N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
            N-\{6-[(7-nitrobenzo-2,1,3-oxadiazol-4-yl)amino]hexanoyl\}sphingosylphosphocholine 0
            SC-4Mor 0
            acridon-2-yl-L-alanine 0
            beta-Ala-Lys-N(epsilon)-AMCA 0
            chlortetracycline 2
            filipin III 20
            fluorescein isothiocyanate + 62
            lissamine rhodamine 0
            pyrene 59
            rac-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester 0
            rhodamine B 0
            sapintoxin D 0
            sodium 8-methoxypyrene-1,3,6-trisulfonate 0
            tetrasulfocyanine 0
            umbelliferone 44
paths to the root