Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azulenofuran
go back to main search page
Accession:CHEBI:39433 term browser browse the term
Synonyms:related_synonym: azulenofurans



show annotations for term's descendants           Sort by:
lactucin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of ACACA protein] CTD PMID:32023857 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in increased expression of ADAM17 mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ADAM17 mRNA] CTD PMID:36055749 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO lactucin results in increased expression of and results in decreased phosphorylation of AKT1 protein
lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
CTD PMID:33995112 PMID:36364182 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO lactucin results in increased expression of BAX protein CTD PMID:36364182 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 protein]
lactucin results in decreased expression of BCL2 mRNA; lactucin results in decreased expression of BCL2 protein
CTD PMID:34302634 PMID:36364182 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases cleavage ISO lactucin results in increased cleavage of CASP3 protein CTD PMID:34302634 PMID:36364182 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO lactucin results in decreased expression of CCNB1 protein CTD PMID:36364182 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO lactucin results in decreased expression of CCND1 protein CTD PMID:36364182 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of CD36 mRNA] CTD PMID:32023857 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO lactucin results in decreased expression of CDK2 protein CTD PMID:36364182 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO lactucin results in decreased expression of CDK4 protein CTD PMID:36364182 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO lactucin results in increased expression of CDKN1A protein CTD PMID:36364182 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of CEBPA mRNA]; lactucin affects the reaction [Dietary Fats affects the expression of CEBPA protein] CTD PMID:32023857 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of CEBPB protein] CTD PMID:32023857 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Acetylcysteine inhibits the reaction [lactucin results in decreased expression of CFLAR protein]; CFLAR protein inhibits the reaction [lactucin results in increased cleavage of PARP1 protein]; lactucin results in decreased expression of and results in increased degradation of CFLAR protein CTD PMID:34302634 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of DGAT1 mRNA] CTD PMID:32023857 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of FAS protein] CTD PMID:32023857 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the activity of GPT protein] CTD PMID:32023857 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in decreased expression of HADHA mRNA]; lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in decreased expression of HADHA protein]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of HADHA mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of HADHA protein] CTD PMID:36055749 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33995112 PMID:39164375 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:33995112 PMID:39164375 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the phosphorylation of JAK2 protein] CTD PMID:32023857 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Ldha lactate dehydrogenase A affects binding ISO lactucin binds to LDHA protein CTD PMID:36364182 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO lactucin results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:36364182 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
lactucin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:33995112 PMID:36364182 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO lactucin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:33995112 PMID:36364182 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33995112 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [lactucin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [lactucin results in increased cleavage of PARP1 protein] CTD PMID:34302634 PMID:36364182 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgm1 phosphoglucomutase 1 affects binding ISO lactucin binds to PGM1 protein CTD PMID:36364182 NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
JBrowse link
G Pkm pyruvate kinase M1/2 affects binding ISO lactucin binds to PKM protein CTD PMID:36364182 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO lactucin affects the reaction [Dietary Fats affects the expression of PPARG mRNA]; lactucin affects the reaction [Dietary Fats affects the expression of PPARG protein] CTD PMID:32023857 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO lactucin results in increased expression of PTEN protein CTD PMID:36364182 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33995112 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Smad3 SMAD family member 3 decreases expression ISO
EXP
lactucin results in decreased expression of SMAD3 protein CTD PMID:39164375 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP
ISO
lactucin results in increased expression of SMAD7 protein CTD PMID:39164375 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in increased expression of SQSTM1 mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SQSTM1 mRNA] CTD PMID:36055749 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases localization
multiple interactions
EXP
ISO
lactucin results in decreased localization of STAT3 protein; lactucin results in decreased localization of STAT3 protein modified form
lactucin affects the reaction [Dietary Fats affects the phosphorylation of STAT3 protein]
CTD PMID:32023857 PMID:39164375 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP
ISO
lactucin results in decreased expression of TGFB1 protein CTD PMID:39164375 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 increases expression EXP lactucin results in increased expression of TLR4 protein CTD PMID:39164375 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:39164375 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO lactucin results in increased expression of TP53 protein CTD PMID:36364182 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          oxygen atom 19541
            oxygen molecular entity 19541
              organooxygen compound 19191
                oxacycle 17906
                  azulenofuran 41
                    (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-\{[(2Z)-2-methylbut-2-enoyl]oxy\}-7-(octanoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4-yl 12-[(tert-butoxycarbonyl)amino]dodecanoate 0
                    11,13-dihydro-8-deoxylactucin 15-glycoside 0
                    11beta,13-dihydro-8-deoxylactucin 0
                    11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                    11beta,13-dihydrolactucin 0
                    11beta,13-dihydrolactucin 15-glycoside 0
                    11beta,13-dihydrolactucin 15-oxalate 0
                    11beta,13-dihydrolactucopicrin 0
                    11beta,13-dihydrolactucopicrin 15-oxalate 0
                    8-deoxylactucin 15-oxalate 0
                    8-deoxylactucin-15-glycoside 0
                    achillin 0
                    acroptilin 0
                    amaralin 0
                    lactucin + 41
                    lactucin 15-glycoside 0
                    lactucin 15-oxalate 0
                    lactucopicrin 0
                    lactucopicrin 15-oxalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      azulenofuran 41
                                        (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-\{[(2Z)-2-methylbut-2-enoyl]oxy\}-7-(octanoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4-yl 12-[(tert-butoxycarbonyl)amino]dodecanoate 0
                                        11,13-dihydro-8-deoxylactucin 15-glycoside 0
                                        11beta,13-dihydro-8-deoxylactucin 0
                                        11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                                        11beta,13-dihydrolactucin 0
                                        11beta,13-dihydrolactucin 15-glycoside 0
                                        11beta,13-dihydrolactucin 15-oxalate 0
                                        11beta,13-dihydrolactucopicrin 0
                                        11beta,13-dihydrolactucopicrin 15-oxalate 0
                                        8-deoxylactucin 15-oxalate 0
                                        8-deoxylactucin-15-glycoside 0
                                        achillin 0
                                        acroptilin 0
                                        amaralin 0
                                        lactucin + 41
                                        lactucin 15-glycoside 0
                                        lactucin 15-oxalate 0
                                        lactucopicrin 0
                                        lactucopicrin 15-oxalate 0
paths to the root