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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dibenzothiazepine
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Accession:CHEBI:39268 term browser browse the term
Synonyms:related_synonym: dibenzothiazepines


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Clotiapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO clothiapine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
quetiapine fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Quetiapine Fumarate results in decreased activity of ABCB1 protein CTD PMID:16810505 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein]; Quetiapine Fumarate inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Quetiapine Fumarate results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Quetiapine Fumarate results in increased expression of BDNF protein CTD PMID:17442489 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cat catalase multiple interactions EXP Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression ISO Quetiapine Fumarate results in decreased expression of CNR1 protein CTD PMID:31220554 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Quetiapine Fumarate results in increased expression of CNR2 protein CTD PMID:31220554 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Carbamazepine promotes the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] CTD PMID:16390352 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Quetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein] CTD PMID:15716360 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity 		ISO Quetiapine Fumarate inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Quetiapine Fumarate results in decreased activity of KCNH2 protein 		CTD PMID:21158687 PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases metabolic processing ISO Quetiapine Fumarate results in decreased metabolism of MAP1LC3B protein CTD PMID:31220554 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Quetiapine Fumarate inhibits the reaction [Cuprizone results in decreased activity of MBP protein] CTD PMID:18938062 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein]; AM 1241 inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; AM 1241 inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein]; AM 281 inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; AM 281 inhibits the reaction [Quetiapine Fumarate results in increased phosphorylation of MLKL protein]; Quetiapine Fumarate results in increased expression of and affects the localization of MLKL protein; Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein; Rimonabant inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:31220554 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
affects oxidation 		ISO Quetiapine Fumarate inhibits the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Quetiapine Fumarate inhibits the reaction [MPO protein results in increased abundance of Hypochlorous Acid]
Quetiapine Fumarate results in decreased activity of MPO protein
MPO protein affects the oxidation of Quetiapine Fumarate 		CTD PMID:35575633 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Quetiapine Fumarate results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520 		JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Quetiapine Fumarate results in decreased expression of NGFR mRNA CTD PMID:12111809 PMID:16513140 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Prl prolactin decreases expression
increases secretion 		ISO Quetiapine Fumarate results in decreased expression of PRL protein
Quetiapine Fumarate results in increased secretion of PRL protein 		CTD PMID:16379509 PMID:18063941 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression 		ISO AM 281 inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein] CTD PMID:31220554 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions
increases expression 		ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK3 protein] CTD PMID:31220554 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression 		ISO
EXP 		Quetiapine Fumarate inhibits the reaction [Cuprizone results in decreased activity of SOD1 protein]
Quetiapine Fumarate results in increased expression of SOD1 mRNA
Quetiapine Fumarate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA] 		CTD PMID:12111809 PMID:12752374 PMID:18938062 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
tianeptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP tianeptine results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP tianeptine results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP tianeptine results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO tianeptine results in decreased expression of ANGPTL3 mRNA CTD PMID:27089845 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444 		JBrowse link
G Cat catalase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19497431 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP tianeptine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP tianeptine results in decreased expression of DRD2 mRNA CTD PMID:11981225 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO tianeptine results in increased expression of IGFBP1 mRNA CTD PMID:27089845 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19497431 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO tianeptine results in increased activity of OPRM1 protein CTD PMID:32734307 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP tianeptine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO tianeptine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP tianeptine results in decreased expression of SLCO1A1 mRNA CTD PMID:27765674 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO tianeptine results in increased expression of SREBF1 mRNA CTD PMID:27089845 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          nitrogen atom 19576
            nitrogen molecular entity 19576
              organonitrogen compound 19311
                organonitrogen heterocyclic compound 18491
                  dibenzothiazepine 33
                    1-butyl-3-(5-methyl-6-oxo-3-benzo[b][1,4]benzothiazepinyl)urea 0
                    1-cyclopropyl-3-[6-oxo-5-(phenylmethyl)-3-benzo[b][1,4]benzothiazepinyl]urea 0
                    5-[(2-fluorophenyl)methyl]-6,11-dioxo-3-benzo[b][1,4]benzothiazepinecarboxylic acid 0
                    6-ethyl-8-methyl-N-(3-pyridinylmethyl)-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                    7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid + 14
                    8-bromo-6-ethyl-N-(2-oxolanylmethyl)-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                    Clotiapine 1
                    N-(2-furanylmethyl)-6-propyl-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                    Norquetiapine 0
                    quetiapine + 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterotricyclic compound 16085
                                      dibenzothiazepine 33
                                        1-butyl-3-(5-methyl-6-oxo-3-benzo[b][1,4]benzothiazepinyl)urea 0
                                        1-cyclopropyl-3-[6-oxo-5-(phenylmethyl)-3-benzo[b][1,4]benzothiazepinyl]urea 0
                                        5-[(2-fluorophenyl)methyl]-6,11-dioxo-3-benzo[b][1,4]benzothiazepinecarboxylic acid 0
                                        6-ethyl-8-methyl-N-(3-pyridinylmethyl)-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                                        7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid + 14
                                        8-bromo-6-ethyl-N-(2-oxolanylmethyl)-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                                        Clotiapine 1
                                        N-(2-furanylmethyl)-6-propyl-3-benzo[b][1,4]benzothiazepinecarboxamide 0
                                        Norquetiapine 0
                                        quetiapine + 23
paths to the root