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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antibiotic acaricide
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Accession:CHEBI:39216 term browser browse the term


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abamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
decreases expression
decreases response to substance
increases expression		 ISO
EXP		 abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCB1 protein
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCB1A protein
abamectin results in decreased expression of ABCB1A protein
ABCB1A protein results in decreased susceptibility to abamectin
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Sesame Oil inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]		 CTD PMID:9144452 PMID:17134887 PMID:19879343 PMID:25865432 PMID:31739238 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCC1 protein		 CTD PMID:25865432 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Actb actin, beta decreases expression ISO abamectin results in decreased expression of ACTB protein CTD PMID:19879343 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO abamectin results in decreased expression of AKT1 protein CTD PMID:30958899 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ano1 anoctamin 1 decreases activity ISO abamectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA] CTD PMID:34748272 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]
abamectin results in increased expression of BAX mRNA; abamectin results in increased expression of BAX protein		 CTD PMID:34748272 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]
abamectin results in decreased expression of BCL2 mRNA; abamectin results in decreased expression of BCL2 protein		 CTD PMID:34748272 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of BECN1 protein
Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]		 CTD PMID:34748272 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 ISO
EXP		 abamectin results in increased activity of CASP3 protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CASP3 protein]
abamectin results in increased expression of CASP3 mRNA; abamectin results in increased expression of CASP3 protein		 CTD PMID:30958899 PMID:31739238 PMID:34748272 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity		 EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased activity of CAT protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Sesame Oil inhibits the reaction [abamectin results in increased activity of CAT protein] CTD PMID:31739238 PMID:34748272 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CYP2E1 protein] CTD PMID:31739238 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions		 EXP abamectin results in increased expression of EIF2AK3 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]		 CTD PMID:34748272 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of ERN1 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]		 CTD PMID:34748272 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA] CTD PMID:34748272 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP abamectin results in increased expression of HSPA5 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]		 CTD PMID:34748272 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP abamectin results in increased expression of IL1B mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]		 CTD PMID:34748272 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA] CTD PMID:34748272 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases expression
multiple interactions		 EXP abamectin results in increased expression of JAK2 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA]		 CTD PMID:34748272 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA] CTD PMID:34748272 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA] CTD PMID:34748272 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
multiple interactions		 EXP abamectin results in increased expression of MAPK14 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]		 CTD PMID:34748272 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA] CTD PMID:34748272 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of NFKB1 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]		 CTD PMID:34748272 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO abamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO abamectin results in decreased expression of SQSTM1 protein CTD PMID:30958899 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions		 EXP abamectin results in increased expression of STAT3 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA]		 CTD PMID:34748272 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP abamectin results in increased expression of TNF mRNA; abamectin results in increased expression of TNF protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Sesame Oil inhibits the reaction [abamectin results in increased expression of TNF protein]		 CTD PMID:31739238 PMID:34748272 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO abamectin results in decreased expression of TUBB3 protein CTD PMID:19879343 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pesticide 18067
          acaricide 13701
            antibiotic acaricide 29
              macrolide acaricide + 29
paths to the root