chlorocycloalkane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	chlorocycloalkane	go back to main search page
Accession:	CHEBI:39155	browse the term
Definition:	A chlorohydrocarbon that is any cycloalkane substituted by at least one chloro group.
Synonyms:	related_synonym:	chlorocycloalkanes

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Genes (513)

alpha-hexachlorocyclohexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

increases expression

alpha-hexachlorocyclohexane results in increased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 3

increases expression

alpha-hexachlorocyclohexane results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases methylation

alpha-hexachlorocyclohexane results in increased methylation of ABL1 promoter

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetyl-CoA acyltransferase 2

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acetyl-CoA acetyltransferase 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

ArfGAP with dual PH domains 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of ADAP2 mRNA

NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

aldehyde dehydrogenase 1 family, member A1

increases expression

alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

apolipoprotein C1

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

amyloid beta precursor protein

increases expression

alpha-hexachlorocyclohexane results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein]

PMID:10696776 PMID:15084347 PMID:21962538 PMID:26022396

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

carbonic anhydrase 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA

PMID:16940010 PMID:17785943

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase 3

increases activity

alpha-hexachlorocyclohexane results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
increases activity

[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
alpha-hexachlorocyclohexane results in increased activity of CAT protein

PMID:1708174 PMID:16046044

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 1

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA

NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096

G

CD36 molecule

increases expression

alpha-hexachlorocyclohexane results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cell division cycle 123

increases expression

alpha-hexachlorocyclohexane results in increased expression of CDC123 mRNA

NCBI chr17:72,459,270...72,503,316
Ensembl chr17:72,459,282...72,503,316

G

cyclin-dependent kinase 17

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of CDK17 mRNA

NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910

G

carboxylesterase 2H

increases expression

alpha-hexachlorocyclohexane results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

coiled-coil-helix-coiled-coil-helix domain containing 2

decreases expression
increases expression
affects expression

alpha-hexachlorocyclohexane results in decreased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in increased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane affects the expression of CHCHD2 mRNA

NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755

G

carboxypeptidase N subunit 1

affects expression
decreases expression
increases expression

alpha-hexachlorocyclohexane affects the expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in increased expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

cathepsin C

decreases expression
affects expression
increases expression

alpha-hexachlorocyclohexane results in decreased expression of CTSC mRNA
alpha-hexachlorocyclohexane affects the expression of CTSC mRNA
alpha-hexachlorocyclohexane results in increased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cytochrome b5 type A

affects expression

alpha-hexachlorocyclohexane affects the expression of CYB5A mRNA

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome b5 reductase 3

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA

NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily a, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases activity

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2B1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 protein
alpha-hexachlorocyclohexane results in increased activity of CYP2B1 protein

PMID:1372805 PMID:11165752 PMID:16246485

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 15

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYP2B2 mRNA

PMID:16940010 PMID:17785943

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 12

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression
multiple interactions

alpha-hexachlorocyclohexane results in increased expression of CYP2C6 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6 protein

PMID:16246485 PMID:16940010

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein

PMID:11165752 PMID:16246485 PMID:16940010

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 4, subfamily a, polypeptide 8

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 51

increases expression

alpha-hexachlorocyclohexane results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

enoyl-CoA delta isomerase 1

decreases expression
affects expression
increases expression

alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNA
alpha-hexachlorocyclohexane affects the expression of ECI1 mRNA
alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

epidermal growth factor

multiple interactions

[EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epithelial cell adhesion molecule

increases expression

alpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

epoxide hydrolase 1

increases expression
increases activity

alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA
alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein

PMID:1372805 PMID:16940010

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

estrogen receptor 1

multiple interactions
increases activity

alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
alpha-hexachlorocyclohexane results in increased activity of ESR1 protein

PMID:10580743 PMID:26022396

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

alpha-hexachlorocyclohexane results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

FEV transcription factor, ETS family member

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of FEV mRNA

NCBI chr 9:76,439,164...76,443,603
Ensembl chr 9:76,439,172...76,443,065

G

fibroblast growth factor 1

decreases response to substance

alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

FKBP prolyl isomerase 3

increases expression

alpha-hexachlorocyclohexane results in increased expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

fibronectin 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

ferritin light chain 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of FTL1 mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases expression
multiple interactions

alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:9316872 PMID:17785943

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression
increases expression
decreases expression

alpha-hexachlorocyclohexane affects the expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in increased expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in decreased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glutathione peroxidase 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione-disulfide reductase

increases expression
multiple interactions

alpha-hexachlorocyclohexane results in increased expression of GSR mRNA
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein

PMID:16046044 PMID:17785943

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of GSTA2 mRNA

PMID:16940010 PMID:17785943

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 5

increases expression

alpha-hexachlorocyclohexane results in increased expression of GSTA5 mRNA

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase kappa 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 4

decreases expression
affects expression
increases expression

alpha-hexachlorocyclohexane results in decreased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane affects the expression of GSTM4 mRNA
alpha-hexachlorocyclohexane results in increased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase pi 1

multiple interactions
increases expression

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of GSTP1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of GSTP1 protein
alpha-hexachlorocyclohexane results in increased expression of GSTP1 mRNA

PMID:16246485 PMID:16940010

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hepatocyte growth factor

increases expression

alpha-hexachlorocyclohexane results in increased expression of HGF protein

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

heat shock protein family B (small) member 1

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

potassium inwardly-rectifying channel, subfamily J, member 5

affects expression

alpha-hexachlorocyclohexane affects the expression of KCNJ5 mRNA

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

alpha-hexachlorocyclohexane results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lipoprotein lipase

increases expression

alpha-hexachlorocyclohexane results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 2

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

LUC7-like 2 pre-mRNA splicing factor

affects expression

alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNA

NCBI chr 4:67,287,593...67,347,986
Ensembl chr 4:67,287,640...67,347,964

G

mitogen activated protein kinase 1

increases expression
decreases expression
affects expression

alpha-hexachlorocyclohexane results in increased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane affects the expression of MAPK1 mRNA

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 6

increases expression

alpha-hexachlorocyclohexane results in increased expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

malic enzyme 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

mesenchyme homeobox 2

increases expression

alpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA

NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467

G

mitochondrially encoded cytochrome c oxidase I

increases expression

alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mucin 13, cell surface associated

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of MUC13 mRNA

NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

neutrophil cytosolic factor 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nucleolin

increases expression

alpha-hexachlorocyclohexane results in increased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

nitric oxide synthase 3

increases expression
multiple interactions

alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA
Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of NQO1 mRNA

PMID:16940010 PMID:17785943

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

alpha-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
alpha-hexachlorocyclohexane results in increased activity of NR1I2 protein

PMID:21115097 PMID:25680588

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

8-oxoguanine DNA glycosylase

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

one cut homeobox 1

affects expression

alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

proliferating cell nuclear antigen

multiple interactions

[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of PCNA protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

progesterone receptor

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

serine protease 8

increases expression

alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA

NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815

G

phosphoserine aminotransferase 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 26S subunit, ATPase 3

increases expression

alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome activator subunit 1

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNA

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

RAB7A, member RAS oncogene family

increases expression

alpha-hexachlorocyclohexane results in increased expression of RAB7 mRNA

NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889

G

RB transcriptional corepressor 1

affects expression
decreases expression
increases expression

alpha-hexachlorocyclohexane affects the expression of RB1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA
alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

arginyl aminopeptidase

decreases expression
affects expression
increases expression

alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA
alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA
alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA

NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998

G

ribosomal protein lateral stalk subunit P0

increases expression

alpha-hexachlorocyclohexane results in increased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

stearoyl-CoA desaturase

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 16 member 1

affects expression
decreases expression
increases expression

alpha-hexachlorocyclohexane affects the expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in increased expression of SLC16A1 mRNA

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 17 member 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of SLC17A1 mRNA

NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304

G

small muscle protein, X-linked

decreases expression

alpha-hexachlorocyclohexane results in decreased expression of SMPX mRNA

NCBI chr X:37,233,209...37,292,266
Ensembl chr X:37,234,294...37,276,708

G

sorting nexin 4

increases expression

alpha-hexachlorocyclohexane results in increased expression of SNX4 mRNA

NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174

G

steroidogenic acute regulatory protein

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

succinate-CoA ligase GDP-forming subunit beta

increases expression

alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

sulfotransferase family 1B member 1

increases expression

alpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

tumor protein p53

increases expression
decreases expression
affects expression

alpha-hexachlorocyclohexane results in increased expression of TP53 mRNA
alpha-hexachlorocyclohexane results in decreased expression of TP53 mRNA
alpha-hexachlorocyclohexane affects the expression of TRP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

ubiquitin C

increases expression

alpha-hexachlorocyclohexane results in increased expression of UBC mRNA

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA

NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNA

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

UDP glycosyltransferase 2 family, polypeptide B

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT2B mRNA

NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

alpha-hexachlorocyclohexane results in increased expression of UGT2B1 mRNA

PMID:16940010 PMID:17785943

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

vasoactive intestinal peptide

multiple interactions

alpha-hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

beta-hexachlorocyclohexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

increases expression

beta-hexachlorocyclohexane results in increased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

increases expression

beta-hexachlorocyclohexane results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

beta-hexachlorocyclohexane results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 8

increases expression

beta-hexachlorocyclohexane results in increased expression of ABCG8 mRNA; beta-hexachlorocyclohexane results in increased expression of ABCG8 protein

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases methylation

beta-hexachlorocyclohexane results in increased methylation of ABL1 promoter

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA dehydrogenase, long chain

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ACADL mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADL protein

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ACADM mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADM protein

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ACADS mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADS protein

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA oxidase 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

adiponectin, C1Q and collagen domain containing

affects response to substance
multiple interactions

ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane
[ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane] which affects the expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensin II receptor, type 1a

decreases expression

beta-hexachlorocyclohexane results in decreased expression of AGTR1A mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

aryl hydrocarbon receptor

affects expression
multiple interactions

beta-hexachlorocyclohexane affects the expression of AHR protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 13

increases expression

beta-hexachlorocyclohexane results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

5'-aminolevulinate synthase 1

increases expression

beta-hexachlorocyclohexane results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

ALG5, dolichyl-phosphate beta-glucosyltransferase

increases expression

beta-hexachlorocyclohexane results in increased expression of ALG5 mRNA

NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216

G

ankyrin 1

increases expression

beta-hexachlorocyclohexane results in increased expression of ANK1 mRNA

NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759

G

apolipoprotein A5

decreases expression

beta-hexachlorocyclohexane results in decreased expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

androgen receptor

multiple interactions
affects expression

beta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide affects the reaction [beta-hexachlorocyclohexane affects the expression of AR protein]

PMID:26022396 PMID:33207735

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ATPase phospholipid transporting 11B (putative)

increases expression

beta-hexachlorocyclohexane results in increased expression of ATP11B mRNA

NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232

G

ATPase copper transporting beta

increases expression

beta-hexachlorocyclohexane results in increased expression of ATP7B mRNA

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

BCR activator of RhoGEF and GTPase

decreases expression

beta-hexachlorocyclohexane results in decreased expression of BCR mRNA

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

BRCA1, DNA repair associated

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

caspase 3

increases cleavage

beta-hexachlorocyclohexane results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

beta-hexachlorocyclohexane results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 63

increases expression

beta-hexachlorocyclohexane results in increased expression of CCDC63 mRNA

NCBI chr12:34,424,388...34,453,080
Ensembl chr12:34,424,344...34,453,085

G

cyclin D1

increases expression
multiple interactions

beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA
fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA]

PMID:17640349 PMID:20206645

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD19 molecule

increases expression

beta-hexachlorocyclohexane results in increased expression of CD19 mRNA

NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975

G

cyclin-dependent kinase inhibitor 1B

increases expression

beta-hexachlorocyclohexane results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

ceramide synthase 6

decreases expression

beta-hexachlorocyclohexane results in decreased expression of CERS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

G

carboxylesterase 1D

increases expression

beta-hexachlorocyclohexane results in increased expression of CES1D mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

COP9 signalosome subunit 8

increases expression

beta-hexachlorocyclohexane results in increased expression of COPS8 mRNA

NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258

G

carnitine palmitoyltransferase 1A

decreases expression

beta-hexachlorocyclohexane results in decreased expression of CPT1A mRNA

PMID:25270620 PMID:28397872

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cathepsin S

increases expression

beta-hexachlorocyclohexane results in increased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450 family 7 subfamily A member 1

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

increases expression

beta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

DAB adaptor protein 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

defensin alpha 5

decreases expression

beta-hexachlorocyclohexane results in decreased expression of DEFA5 mRNA

NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836

G

dopamine receptor D2

decreases expression

beta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

beta-hexachlorocyclohexane results in decreased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dynein 2 intermediate chain 1

increases expression

beta-hexachlorocyclohexane results in increased expression of DYNC2I1 mRNA

NCBI chr 6:137,133,418...137,189,937
Ensembl chr 6:137,133,418...137,188,719

G

eukaryotic translation initiation factor 2B subunit gamma

increases expression

beta-hexachlorocyclohexane results in increased expression of EIF2B3 mRNA

NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332

G

epithelial membrane protein 2

decreases expression

beta-hexachlorocyclohexane results in decreased expression of EMP2 mRNA

NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733

G

erythrocyte membrane protein band 4.1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of EPB41 mRNA

NCBI chr 5:144,110,010...144,264,037
Ensembl chr 5:144,111,906...144,237,821

G

erb-b2 receptor tyrosine kinase 2

increases expression
multiple interactions
increases activity

beta-hexachlorocyclohexane results in increased expression of ERBB2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]
beta-hexachlorocyclohexane results in increased activity of ERBB2 protein
beta-hexachlorocyclohexane results in increased expression of ERBB2 protein

PMID:9443065 PMID:11222871 PMID:12439862 PMID:12948864 PMID:17640349

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

endoplasmic reticulum metallopeptidase 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ERMP1 mRNA

NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909

G

estrogen receptor 1

decreases expression
increases expression
multiple interactions
increases activity

beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA; beta-hexachlorocyclohexane results in decreased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased expression of ESR1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]
beta-hexachlorocyclohexane results in increased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased activity of ESR1 protein
[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNA; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]

PMID:12948864 PMID:15064155 PMID:15541753 PMID:16758953 PMID:20206645 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases activity

beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein]
beta-hexachlorocyclohexane results in increased activity of ESR2 protein

PMID:15064155 PMID:21278053

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ETS variant transcription factor 1

increases expression

beta-hexachlorocyclohexane results in increased expression of ETV1 mRNA

NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775

G

exosome component 8

increases expression

beta-hexachlorocyclohexane results in increased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

G

fatty acid binding protein 5

increases expression

beta-hexachlorocyclohexane results in increased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

family with sequence similarity 107, member A

decreases expression

beta-hexachlorocyclohexane results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

Fas ligand

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

increases expression

beta-hexachlorocyclohexane results in increased expression of FASN protein

PMID:27203212 PMID:28397872

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 19

decreases expression

beta-hexachlorocyclohexane results in decreased expression of FGF15 mRNA

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

glucose-6-phosphate dehydrogenase

increases activity

beta-hexachlorocyclohexane results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gonadotropin releasing hormone 1

multiple interactions

[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of GNRH1 mRNA

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

G protein-coupled receptor 146

decreases expression

beta-hexachlorocyclohexane results in decreased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

glutathione-disulfide reductase

multiple interactions

[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

affects response to substance

GSTM1 gene polymorphism affects the susceptibility to beta-hexachlorocyclohexane

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

H2A.X variant histone

increases phosphorylation

beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heme oxygenase 1

increases expression

beta-hexachlorocyclohexane results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hyaluronidase 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of HYAL1 mRNA

NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210

G

insulin-like growth factor 1 receptor

increases expression

beta-hexachlorocyclohexane results in increased expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

immunoglobulin superfamily, member 3

increases expression

beta-hexachlorocyclohexane results in increased expression of IGSF3 mRNA

NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645

G

insulin 1

decreases secretion

beta-hexachlorocyclohexane results in decreased secretion of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

beta-hexachlorocyclohexane results in increased expression of JMJD6 mRNA

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[beta-hexachlorocyclohexane co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of JUN mRNA
beta-hexachlorocyclohexane results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KN motif and ankyrin repeat domains 3

decreases expression

beta-hexachlorocyclohexane results in decreased expression of KANK3 mRNA

NCBI chr 7:14,594,358...14,607,675
Ensembl chr 7:14,594,422...14,607,675

G

potassium voltage-gated channel subfamily D member 2

decreases expression

beta-hexachlorocyclohexane results in decreased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

KDEL endoplasmic reticulum protein retention receptor 2

increases expression

beta-hexachlorocyclohexane results in increased expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153

G

kinesin family member 24

increases expression

beta-hexachlorocyclohexane results in increased expression of KIF24 mRNA

NCBI chr 5:56,561,019...56,628,040
Ensembl chr 5:56,561,154...56,628,025

G

kallikrein 1-related peptidase C10

increases expression
multiple interactions

beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA
bicalutamide inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

keratin 19

increases expression

beta-hexachlorocyclohexane results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

lipocalin 8

decreases expression

beta-hexachlorocyclohexane results in decreased expression of LCN8 mRNA

NCBI chr 3:8,467,934...8,473,691
Ensembl chr 3:8,467,934...8,470,918

G

mitogen activated protein kinase 1

decreases expression
multiple interactions

beta-hexachlorocyclohexane results in decreased expression of MAPK1 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein

PMID:12948864 PMID:20206645

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases expression
multiple interactions

beta-hexachlorocyclohexane results in decreased expression of MAPK3 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:12948864 PMID:20206645

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

mitochondrial genome maintenance exonuclease 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of MGME1 mRNA

NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932

G

matrix metallopeptidase 12

increases expression

beta-hexachlorocyclohexane results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

increases expression

beta-hexachlorocyclohexane results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 9

increases expression

beta-hexachlorocyclohexane results in increased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

maestro heat-like repeat family member 9

increases expression

beta-hexachlorocyclohexane results in increased expression of MROH9 mRNA

NCBI chr13:75,387,800...75,443,118
Ensembl chr13:75,387,746...75,443,092

G

myosin regulatory light chain interacting protein

decreases expression

beta-hexachlorocyclohexane results in decreased expression of MYLIP mRNA

NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295

G

myosin IE

decreases expression

beta-hexachlorocyclohexane results in decreased expression of MYO1E mRNA

NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169

G

NAD kinase

increases expression

beta-hexachlorocyclohexane results in increased expression of NADK mRNA

NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322

G

nuclear receptor subfamily 1, group H, member 4

increases expression

beta-hexachlorocyclohexane results in increased expression of NR1H4 mRNA

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

beta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 2, group C, member 1

increases expression

beta-hexachlorocyclohexane results in increased expression of NR2C1 mRNA

NCBI chr 7:28,715,347...28,768,624
Ensembl chr 7:28,715,562...28,767,160

G

neurotensin receptor 2

increases expression

beta-hexachlorocyclohexane results in increased expression of NTSR2 mRNA

NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014

G

platelet derived growth factor receptor beta

decreases expression

beta-hexachlorocyclohexane results in decreased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of PFKFB1 mRNA

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182

G

progesterone receptor

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; beta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]
beta-hexachlorocyclohexane results in increased expression of PGR; beta-hexachlorocyclohexane results in increased expression of PGR mRNA

PMID:2479123 PMID:16242299 PMID:20206645 PMID:26022396

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phospholipase A2, group XIIA

increases expression

beta-hexachlorocyclohexane results in increased expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740

G

phospholipase A2, group XV

decreases expression

beta-hexachlorocyclohexane results in decreased expression of PLA2G15 mRNA

NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063

G

RNA polymerase I subunit B

decreases expression

beta-hexachlorocyclohexane results in decreased expression of POLR1B mRNA

NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379

G

proopiomelanocortin

multiple interactions

[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

cytochrome p450 oxidoreductase

increases expression

beta-hexachlorocyclohexane results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

prolactin

multiple interactions
increases expression

ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

pre-mRNA processing factor 18

decreases expression

beta-hexachlorocyclohexane results in decreased expression of PRPF18 mRNA

NCBI chr17:73,630,560...73,661,210
Ensembl chr17:73,630,571...73,690,979

G

proteasome 26S subunit, non-ATPase 12

increases expression

beta-hexachlorocyclohexane results in increased expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

prostaglandin E synthase

increases expression

beta-hexachlorocyclohexane results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

retinol dehydrogenase 9

decreases expression

beta-hexachlorocyclohexane results in decreased expression of RDH9 mRNA

NCBI chr 7:63,642,305...63,645,149

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulator of G-protein signaling 3

increases expression

beta-hexachlorocyclohexane results in increased expression of RGS3 mRNA

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

stearoyl-CoA desaturase

increases expression

beta-hexachlorocyclohexane results in increased expression of SCD1 mRNA; beta-hexachlorocyclohexane results in increased expression of SCD1 protein

PMID:27203212 PMID:28397872

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serpin family A member 7

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SERPINA7 protein

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

SH3 domain containing 21

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SH3D21 mRNA

NCBI chr 5:138,429,180...138,444,540
Ensembl chr 5:138,429,180...138,444,407

G

solute carrier family 10 member 1

increases expression

beta-hexachlorocyclohexane results in increased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 10 member 2

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SLC10A2 mRNA

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 27 member 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SLC27A1 mRNA

NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063

G

solute carrier family 29 member 1

increases expression

beta-hexachlorocyclohexane results in increased expression of SLC29A1 mRNA

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 2 member 4

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SLC2A4 protein

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 51 member A

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SLC51A mRNA

NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485

G

SLC51 subunit beta

decreases expression

beta-hexachlorocyclohexane results in decreased expression of SLC51B mRNA

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

syntrophin, beta 2

increases expression

beta-hexachlorocyclohexane results in increased expression of SNTB2 mRNA

NCBI chr19:34,831,657...34,922,325
Ensembl chr19:34,831,584...34,914,113

G

sperm associated antigen 16

increases expression

beta-hexachlorocyclohexane results in increased expression of SPAG16 mRNA

NCBI chr 9:71,333,005...72,252,772
Ensembl chr 9:71,332,992...72,252,708

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

Snf2-related CREBBP activator protein

increases expression

beta-hexachlorocyclohexane results in increased expression of SRCAP mRNA

NCBI chr 1:182,123,562...182,172,643
Ensembl chr 1:182,118,416...182,176,610

G

sterol regulatory element binding transcription factor 1

decreases expression
increases expression

beta-hexachlorocyclohexane results in decreased expression of SREBF1 mRNA
beta-hexachlorocyclohexane results in increased expression of SREBF1 mRNA; beta-hexachlorocyclohexane results in increased expression of SREBF1 protein

PMID:25270620 PMID:27203212

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transforming, acidic coiled-coil containing protein 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of TACC1 mRNA

NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733

G

trefoil factor 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]

PMID:8968093 PMID:16242299 PMID:20206645

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

THUMP domain containing 2

decreases expression

beta-hexachlorocyclohexane results in decreased expression of THUMPD2 mRNA

NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657

G

tensin 1

decreases expression

beta-hexachlorocyclohexane results in decreased expression of TNS1 mRNA

NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225

G

tropomyosin 3

decreases expression

beta-hexachlorocyclohexane results in decreased expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

tripartite motif-containing 42

increases expression

beta-hexachlorocyclohexane results in increased expression of TRIM42 mRNA

NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268

G

thyroid stimulating hormone subunit beta

multiple interactions

beta-hexachlorocyclohexane affects the expression of and affects the secretion of TSHB protein

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

tumor suppressing subtransferable candidate 4

decreases expression

beta-hexachlorocyclohexane results in decreased expression of TSSC4 mRNA

NCBI chr 1:198,251,986...198,254,810
Ensembl chr 1:198,235,487...198,254,980

G

tetratricopeptide repeat domain 39B

increases expression

beta-hexachlorocyclohexane results in increased expression of TTC39B mRNA

NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270

G

zinc finger protein 3

increases expression

beta-hexachlorocyclohexane results in increased expression of ZFP113 mRNA

NCBI chr12:17,022,104...17,033,776
Ensembl chr12:17,022,279...17,033,709

G

zinc finger protein 597

decreases expression

beta-hexachlorocyclohexane results in decreased expression of ZFP597 mRNA

NCBI chr10:11,653,169...11,658,843
Ensembl chr10:11,653,127...11,660,675

delta-hexachlorocyclohexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]

PMID:10696776 PMID:26022396

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

caspase 3

increases activity

delta-hexachlorocyclohexane results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

decreases activity
multiple interactions

delta-hexachlorocyclohexane results in decreased activity of CDIPT protein
[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; delta-hexachlorocyclohexane inhibits the reaction [CDIPT protein results in increased chemical synthesis of Cytidine Diphosphate Diglycerides]

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

G

estrogen receptor 1

increases activity

delta-hexachlorocyclohexane results in increased activity of ESR1 protein

PMID:15064155 PMID:26022396

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

delta-hexachlorocyclohexane results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
delta-hexachlorocyclohexane results in decreased expression of FOS mRNA; delta-hexachlorocyclohexane results in decreased expression of FOS protein

PMID:1380685 PMID:7534335

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]

PMID:9316872 PMID:11156579

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 4

multiple interactions

delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha6

multiple interactions

delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

gamma-aminobutyric acid type A receptor subunit beta1

multiple interactions

delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit beta 3

multiple interactions

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]

PMID:9316872 PMID:11156579

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glutathione-disulfide reductase

multiple interactions

[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

delta-hexachlorocyclohexane results in decreased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

delta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

progesterone receptor

multiple interactions

delta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

sex hormone binding globulin

multiple interactions

delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

steroidogenic acute regulatory protein

multiple interactions

delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

gamma-hexachlorocyclohexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

Hexachlorocyclohexane results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Hexachlorocyclohexane results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 3

increases expression

Hexachlorocyclohexane results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

increases expression

Hexachlorocyclohexane results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

increases expression

Hexachlorocyclohexane results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases methylation

Hexachlorocyclohexane results in increased methylation of ABL1 promoter

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetylcholinesterase

multiple interactions
decreases activity
increases activity
affects activity

Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
Hexachlorocyclohexane results in decreased activity of ACHE protein
Hexachlorocyclohexane results in increased activity of ACHE protein
Hexachlorocyclohexane affects the activity of ACHE protein

PMID:6186625 PMID:19893075 PMID:20663516

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

decreases expression
affects activity

Hexachlorocyclohexane results in decreased expression of ACLY mRNA
Hexachlorocyclohexane affects the activity of ACLY protein

PMID:7535533 PMID:17785943

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aconitase 2

increases expression

Hexachlorocyclohexane results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA synthetase long-chain family member 5

decreases expression

Hexachlorocyclohexane results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

actin, beta

affects expression

Hexachlorocyclohexane affects the expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

activin A receptor type 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

activin A receptor type 1C

increases expression

Hexachlorocyclohexane results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

adducin 3

affects expression

Hexachlorocyclohexane affects the expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

aryl hydrocarbon receptor

increases expression

Hexachlorocyclohexane results in increased expression of AHR mRNA

PMID:17785943 PMID:25572523

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 4

decreases expression

Hexachlorocyclohexane results in decreased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 7 member A3

increases expression

Hexachlorocyclohexane results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

AKT serine/threonine kinase 1

decreases phosphorylation

Hexachlorocyclohexane results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 8 family, member A1

increases expression

Hexachlorocyclohexane results in increased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

ALK receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression
increases activity

[Hexachlorocyclohexane co-treated with isoproturon] results in decreased activity of ALPL protein; [Hexachlorocyclohexane co-treated with isoproturon] results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased activity of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

apolipoprotein B

affects expression

Hexachlorocyclohexane affects the expression of APOB mRNA

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

androgen receptor

affects binding
multiple interactions

Hexachlorocyclohexane binds to AR protein
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]

PMID:14565775 PMID:21295777 PMID:26022396

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

armadillo repeat containing 6

decreases expression

Hexachlorocyclohexane results in decreased expression of ARMC6 mRNA

NCBI chr16:19,191,106...19,201,528
Ensembl chr16:19,191,093...19,206,047

G

aryl hydrocarbon receptor nuclear translocator

increases expression

Hexachlorocyclohexane results in increased expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arylsulfatase A

decreases activity

Hexachlorocyclohexane results in decreased activity of ARSA protein

NCBI chr 7:120,542,788...120,547,577
Ensembl chr 7:120,543,362...120,548,783

G

agouti signaling protein

increases response to substance

A mutant form results in increased susceptibility to Hexachlorocyclohexane

NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Hexachlorocyclohexane results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

ATP synthase F1 subunit delta

decreases expression

Hexachlorocyclohexane results in decreased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase inhibitory factor subunit 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of BAX mRNA; Hexachlorocyclohexane results in increased expression of BAX protein
Hexachlorocyclohexane results in decreased expression of BAX protein
Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]

PMID:14688026 PMID:18174961 PMID:19041923

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions
decreases activity

Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Hexachlorocyclohexane results in decreased activity of BCHE protein

PMID:20455324 PMID:20663516

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of BCL2 protein
Hexachlorocyclohexane results in increased expression of BCL2 mRNA; Hexachlorocyclohexane results in increased expression of BCL2 protein
[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]

PMID:14688026 PMID:18174961 PMID:19041923

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of BCL2L1 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]

PMID:19041923 PMID:22001173

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BCL6, transcription repressor

increases expression

Hexachlorocyclohexane results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

increases expression

Hexachlorocyclohexane results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

affects expression
multiple interactions

Hexachlorocyclohexane affects the expression of BECN1 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

basic helix-loop-helix family, member a15

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA

NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713

G

basic helix-loop-helix family, member e40

decreases expression

Hexachlorocyclohexane results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 3

increases expression

Hexachlorocyclohexane results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

similar to human chromosome 15 open reading frame 39

decreases expression

Hexachlorocyclohexane results in decreased expression of C15ORF39 mRNA

NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941

G

calreticulin

decreases expression

Hexachlorocyclohexane results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

cysteinyl-tRNA synthetase 1

increases expression

Hexachlorocyclohexane results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 3

increases expression
increases activity
multiple interactions
decreases activity

Hexachlorocyclohexane results in increased expression of CASP3 mRNA; Hexachlorocyclohexane results in increased expression of CASP3 protein
Hexachlorocyclohexane results in increased activity of CASP3 protein
[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP3 protein; Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]
Hexachlorocyclohexane results in decreased activity of CASP3 protein

PMID:19038305 PMID:19041923 PMID:19221147 PMID:19815060 PMID:20036686 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression
multiple interactions
increases activity
decreases activity

Hexachlorocyclohexane results in increased expression of CASP9 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]
Hexachlorocyclohexane results in decreased activity of CASP9 protein

PMID:19038305 PMID:19041923 PMID:22001173

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

increases expression

Hexachlorocyclohexane results in increased expression of CAST mRNA

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

multiple interactions
increases activity
decreases activity

Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]
Hexachlorocyclohexane results in increased activity of CAT protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]

PMID:1708174 PMID:2429406 PMID:2469257 PMID:9057899 PMID:9467884 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin G2

increases expression

Hexachlorocyclohexane results in increased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

Cd47 molecule

decreases expression

Hexachlorocyclohexane results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

Cd69 molecule

increases expression

Hexachlorocyclohexane results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

CD84 molecule

increases expression

Hexachlorocyclohexane results in increased expression of CD84 mRNA

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

G

cell division cycle 42

decreases expression

Hexachlorocyclohexane results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

affects activity

Hexachlorocyclohexane affects the activity of CDIPT protein

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

G

cyclin-dependent kinase inhibitor 1A

increases expression
decreases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of CDKN1A mRNA; Hexachlorocyclohexane results in increased expression of CDKN1A protein
Hexachlorocyclohexane results in decreased expression of CDKN1A protein
Hexachlorocyclohexane affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased expression of CDKN1A protein]

PMID:14688026 PMID:17785943 PMID:18174961

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein beta

increases expression

Hexachlorocyclohexane results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

carboxylesterase 2H

increases expression

Hexachlorocyclohexane results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Hexachlorocyclohexane results in increased expression of CHAC1 mRNA

PMID:23824090 PMID:24356939

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

cell death-inducing DFFA-like effector a

decreases expression

Hexachlorocyclohexane results in decreased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytokine inducible SH2-containing protein

decreases expression

Hexachlorocyclohexane results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

Hexachlorocyclohexane results in increased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

chloride voltage-gated channel 5

decreases expression

Hexachlorocyclohexane results in decreased expression of CLCN5 mRNA

NCBI chr X:15,185,380...15,339,977
Ensembl chr X:15,185,451...15,334,264

G

clusterin

increases expression

Hexachlorocyclohexane results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cyclic nucleotide gated channel subunit alpha 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CNGA1 mRNA

NCBI chr14:35,566,947...35,605,065
Ensembl chr14:35,567,125...35,605,065

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases activity

Hexachlorocyclohexane results in decreased activity of CNP protein

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

carboxypeptidase D

increases expression

Hexachlorocyclohexane results in increased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

cysteine rich transmembrane BMP regulator 1

increases expression

Hexachlorocyclohexane results in increased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

cystatin 8

affects expression

Hexachlorocyclohexane affects the expression of CST8 mRNA

NCBI chr 3:136,244,586...136,255,412
Ensembl chr 3:136,244,636...136,251,273

G

C-X3-C motif chemokine receptor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

cytochrome c, somatic

affects expression

Hexachlorocyclohexane affects the expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of CYP11A1 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]

PMID:15749814 PMID:17080404

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity
decreases activity

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
Hexachlorocyclohexane results in increased expression of CYP19A1 mRNA
Hexachlorocyclohexane results in increased activity of CYP19A1 protein
Hexachlorocyclohexane results in decreased activity of CYP19A1 protein

PMID:12849724 PMID:17080404

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions

Hexachlorocyclohexane results in increased activity of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of CYP1A1 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]
Hexachlorocyclohexane inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

PMID:11684361 PMID:12842176 PMID:15620088 PMID:16641539 PMID:17919674 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
increases expression
multiple interactions

Hexachlorocyclohexane results in increased activity of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of CYP1A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]

PMID:12842176 PMID:16641539 PMID:17919674 PMID:17984293 PMID:18486174 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases activity

Hexachlorocyclohexane results in increased activity of CYP2A1 protein

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression
multiple interactions
increases activity

Hexachlorocyclohexane results in increased expression of CYP2B1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]
Hexachlorocyclohexane results in increased activity of CYP2B1 protein

PMID:11684361 PMID:12842176 PMID:17919674 PMID:17984293 PMID:18486174 More...

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions
increases activity

Hexachlorocyclohexane results in increased expression of CYP2B2 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]
Hexachlorocyclohexane results in increased activity of CYP2B2 protein

PMID:11684361 PMID:12842176 PMID:17785943 PMID:17919674 PMID:17984293 More...

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Hexachlorocyclohexane results in increased expression of CYP2B6 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B6 protein

PMID:15548381 PMID:20035023

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

increases expression

Hexachlorocyclohexane results in increased expression of CYP2C11 mRNA; Hexachlorocyclohexane results in increased expression of CYP2C11 protein

PMID:11684361 PMID:16837770

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 12

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

Hexachlorocyclohexane results in increased expression of CYP2D1 mRNA

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases activity
increases expression
decreases response to substance
decreases expression

Hexachlorocyclohexane results in increased activity of CYP2E1 protein
Hexachlorocyclohexane results in increased expression of CYP2E1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Hexachlorocyclohexane
Hexachlorocyclohexane results in decreased expression of CYP2E1 mRNA

PMID:12842176 PMID:14631868 PMID:17919674 PMID:17984293 PMID:20035023 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases activity

Hexachlorocyclohexane results in increased expression of CYP3A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP3A2 protein
Hexachlorocyclohexane results in increased expression of CYP3A4 protein
Hexachlorocyclohexane results in increased activity of CYP3A2 protein

PMID:3569844 PMID:11684361 PMID:15548381 PMID:16837770

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
affects expression

Hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA
Hexachlorocyclohexane affects the expression of CYP3A23-3A1 mRNA

PMID:14613717 PMID:22001173 PMID:25572523

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 51

increases expression

Hexachlorocyclohexane results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

death associated protein 3

increases expression

Hexachlorocyclohexane results in increased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

decorin

decreases expression

Hexachlorocyclohexane results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Hexachlorocyclohexane results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member C5

decreases expression

Hexachlorocyclohexane results in decreased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

dopamine receptor D2

increases expression

Hexachlorocyclohexane results in increased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

increases expression

Hexachlorocyclohexane results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

eukaryotic translation elongation factor 1 alpha 1

affects expression

Hexachlorocyclohexane affects the expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

early growth response 1

increases expression

Hexachlorocyclohexane results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2B subunit gamma

affects expression

Hexachlorocyclohexane affects the expression of EIF2B3 mRNA

NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332

G

eukaryotic translation initiation factor 2B subunit delta

affects expression

Hexachlorocyclohexane affects the expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 5

increases expression

Hexachlorocyclohexane results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

Eph receptor A3

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA

NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900

G

Eph receptor A8

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

estrogen receptor 1

multiple interactions
increases activity
affects binding
decreases expression

[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
Hexachlorocyclohexane results in increased activity of ESR1 protein
Hexachlorocyclohexane binds to ESR1 protein
Hexachlorocyclohexane results in decreased expression of ESR1 protein
Hexachlorocyclohexane binds to and results in increased activity of ESR1 protein

PMID:14579009 PMID:15253041 PMID:16329587 PMID:20209442 PMID:21278053 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

Hexachlorocyclohexane results in increased activity of ESR2 protein

PMID:15064155 PMID:26139245

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

increases expression

Hexachlorocyclohexane results in increased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ecotropic viral integration site 2A

increases expression

Hexachlorocyclohexane results in increased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

family with sequence similarity 107, member B

increases expression

Hexachlorocyclohexane results in increased expression of FAM107B mRNA

NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989

G

Fas cell surface death receptor

increases expression

Hexachlorocyclohexane results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Hexachlorocyclohexane results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

affects activity

Hexachlorocyclohexane affects the activity of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

F-box protein 32

increases expression

Hexachlorocyclohexane results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

FKBP prolyl isomerase 3

affects expression

Hexachlorocyclohexane affects the expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

fibronectin 1

affects expression

Hexachlorocyclohexane affects the expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of FOS mRNA
alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
Hexachlorocyclohexane results in increased expression of FOS mRNA; Hexachlorocyclohexane results in increased expression of FOS protein
W 7 inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]

PMID:1380685 PMID:1710164 PMID:7531829 PMID:7534335 PMID:10072926

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A1

decreases expression

Hexachlorocyclohexane results in decreased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

FRAT regulator of WNT signaling pathway 1

increases expression

Hexachlorocyclohexane results in increased expression of FRAT1 mRNA

NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945

G

follicle stimulating hormone subunit beta

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphate dehydrogenase

affects activity
increases activity

Hexachlorocyclohexane affects the activity of G6PD protein
Hexachlorocyclohexane results in increased activity of G6PD protein

PMID:2461408 PMID:7535533 PMID:8519523

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

decreases expression

Hexachlorocyclohexane results in decreased expression of GABARAPL2 mRNA

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
increases expression

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Hexachlorocyclohexane results in increased expression of GABRA1 mRNA

PMID:9316872 PMID:11156579 PMID:14637376 PMID:25572523

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944

G

gamma-aminobutyric acid type A receptor subunit alpha6

multiple interactions

Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

gamma-aminobutyric acid type A receptor subunit beta1

affects binding
multiple interactions

Hexachlorocyclohexane binds to GABRB1 protein
Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]

PMID:11156579 PMID:11489356

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit beta 3

affects binding
multiple interactions

Hexachlorocyclohexane binds to GABRB3 protein
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:9316872 PMID:11312652 PMID:11489356 PMID:16537435

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:9316872 PMID:11156579 PMID:14637376

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

gamma-aminobutyric acid type A receptor subunit rho 1

affects binding

Hexachlorocyclohexane binds to GABRR1 protein

NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228

G

GATA binding protein 3

increases expression

Hexachlorocyclohexane results in increased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucokinase

increases expression

Hexachlorocyclohexane results in increased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Hexachlorocyclohexane results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Hexachlorocyclohexane results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GDNF family receptor alpha 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

G

gamma-glutamyltransferase 1

multiple interactions
affects activity
decreases activity
increases activity

Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in increased activity of GGT1 protein]
Hexachlorocyclohexane affects the activity of GGT1 protein
Hexachlorocyclohexane results in decreased activity of GGT1 protein

PMID:8519523 PMID:9475050 PMID:11349524

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

affects localization
increases expression
decreases phosphorylation
decreases expression
increases degradation
increases phosphorylation
multiple interactions

Hexachlorocyclohexane affects the localization of GJA1 protein
Hexachlorocyclohexane results in increased expression of GJA1 protein
Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein
Hexachlorocyclohexane results in decreased expression of GJA1 mRNA; Hexachlorocyclohexane results in decreased expression of GJA1 protein
Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form
Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]; Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane affects the localization of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]

PMID:7530866 PMID:8824497 PMID:11532877 PMID:12807735 PMID:15194225 More...

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycine receptor, alpha 1

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA1 protein

NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162

G

glycine receptor, alpha 2

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA2 protein

NCBI chr X:29,020,377...29,241,666
Ensembl chr X:29,020,557...29,241,666

G

glycine receptor, alpha 3

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA3 protein

NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753

G

glutamate-ammonia ligase

decreases expression

Hexachlorocyclohexane results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glycine-N-acyltransferase

affects expression

Hexachlorocyclohexane affects the expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

G protein subunit alpha 12

affects expression

Hexachlorocyclohexane affects the expression of GNA12 mRNA

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

gonadotropin releasing hormone 1

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glutamic-oxaloacetic transaminase 1

increases expression

Hexachlorocyclohexane results in increased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycerol-3-phosphate acyltransferase 3

increases expression

Hexachlorocyclohexane results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

G protein-coupled receptor 18

increases expression

Hexachlorocyclohexane results in increased expression of GPR18 mRNA

PMID:23824090 PMID:24356939

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

[Hexachlorocyclohexane co-treated with isoproturon] results in increased activity of GPT protein
Hexachlorocyclohexane results in increased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamic--pyruvic transaminase 2

increases expression

Hexachlorocyclohexane results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione-disulfide reductase

multiple interactions
increases expression
decreases activity
increases activity

[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Permethrin] results in decreased activity of GSR protein; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]
Hexachlorocyclohexane results in increased expression of GSR mRNA
Hexachlorocyclohexane results in increased activity of GSR protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in increased activity of GSR protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]

PMID:1716606 PMID:9704597 PMID:10817630 PMID:11349524 PMID:11404799 More...

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

affects expression

Hexachlorocyclohexane affects the expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 5

increases expression

Hexachlorocyclohexane results in increased expression of GSTA5 mRNA

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glucuronidase, beta

affects activity

Hexachlorocyclohexane affects the activity of GUSB protein

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hemoglobin, epsilon 2

decreases expression

Hexachlorocyclohexane results in decreased expression of HBG2 protein

NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hepatocyte nuclear factor 4, alpha

affects expression

Hexachlorocyclohexane affects the expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

4-hydroxyphenylpyruvate dioxygenase

increases expression

Hexachlorocyclohexane results in increased expression of HPD mRNA

NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases activity

Hexachlorocyclohexane results in decreased activity of HSD17B1 protein

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases activity

Hexachlorocyclohexane results in decreased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of HSD3B2 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 1A

affects localization

Hexachlorocyclohexane affects the localization of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 4

increases expression

Hexachlorocyclohexane results in increased expression of HSPA4 protein

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

5-hydroxytryptamine receptor 2A

increases expression

Hexachlorocyclohexane results in increased expression of HTR2A mRNA

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

HYLS1, centriolar and ciliogenesis associated

decreases expression

Hexachlorocyclohexane results in decreased expression of HYLS1 mRNA

NCBI chr 8:33,912,692...33,921,760
Ensembl chr 8:33,912,692...33,921,760

G

inhibitor of DNA binding 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NADP(+)) 1

affects expression

Hexachlorocyclohexane affects the expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

immediate early response 3

increases expression

Hexachlorocyclohexane results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon gamma

decreases expression

Hexachlorocyclohexane results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 alpha

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]
Hexachlorocyclohexane results in increased expression of IL1A mRNA; Hexachlorocyclohexane results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 5

decreases expression

Hexachlorocyclohexane results in decreased expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

insulin receptor substrate 1

decreases phosphorylation

Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

ISL LIM homeobox 2

increases expression

Hexachlorocyclohexane results in increased expression of ISL2 mRNA

NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation
multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of JUN protein
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of JUN protein

PMID:15888667 PMID:23927878

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 21B

increases expression

Hexachlorocyclohexane results in increased expression of KIF21B mRNA

NCBI chr13:47,576,129...47,626,112
Ensembl chr13:47,576,160...47,626,127

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KLF transcription factor 9

increases expression

Hexachlorocyclohexane results in increased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch-like family member 24

increases expression

Hexachlorocyclohexane results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lactate dehydrogenase A

decreases expression

Hexachlorocyclohexane results in decreased expression of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

decreases expression

Hexachlorocyclohexane results in decreased expression of LDHB protein

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

leptin

affects expression

Hexachlorocyclohexane affects the expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

Hexachlorocyclohexane results in decreased expression of LHCGR protein

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

LIF, interleukin 6 family cytokine

increases expression

Hexachlorocyclohexane results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

leucine rich repeat containing 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

lymphatic vessel endothelial hyaluronan receptor 1

increases expression

Hexachlorocyclohexane results in increased expression of XLKD1 mRNA

NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Hexachlorocyclohexane results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

multiple interactions

Hexachlorocyclohexane promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

Hexachlorocyclohexane results in decreased expression of MAP4K4 mRNA

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein

PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myelin basic protein

decreases expression
affects expression

Hexachlorocyclohexane results in decreased expression of MBP protein
Hexachlorocyclohexane affects the expression of MBP mRNA

PMID:1701514 PMID:22954530

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

membrane-bound transcription factor peptidase, site 2

increases expression

Hexachlorocyclohexane results in increased expression of MBTPS2 mRNA

NCBI chr X:37,410,914...37,461,130
Ensembl chr X:37,410,811...37,464,430

G

mesenchyme homeobox 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MEOX2 mRNA

NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467

G

MER proto-oncogene, tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

myeloperoxidase

multiple interactions
increases activity

[Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein
Hexachlorocyclohexane results in increased activity of MPO protein

PMID:7503757 PMID:11141352

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

metallothionein 1

increases expression

Hexachlorocyclohexane results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

mitochondrial carrier 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

Hexachlorocyclohexane results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Hexachlorocyclohexane results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 3

affects expression

Hexachlorocyclohexane affects the expression of MYH3 mRNA

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

nanos C2HC-type zinc finger 1

decreases expression

Hexachlorocyclohexane results in decreased expression of NANOS1 mRNA

NCBI chr 1:259,897,663...259,901,561
Ensembl chr 1:259,897,939...259,898,730

G

nuclear receptor coactivator 7

increases expression

Hexachlorocyclohexane results in increased expression of NCOA7 mRNA

NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871

G

NFE2 like bZIP transcription factor 2

decreases expression

Hexachlorocyclohexane results in decreased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFE2 like bZIP transcription factor 3

decreases expression

Hexachlorocyclohexane results in decreased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nuclear factor I/A

decreases expression

Hexachlorocyclohexane results in decreased expression of NFIA mRNA

NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885

G

nuclear factor I/B

decreases expression

Hexachlorocyclohexane results in decreased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nuclear factor I X

increases expression

Hexachlorocyclohexane results in increased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

multiple interactions
increases phosphorylation
increases activity

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]
Hexachlorocyclohexane results in increased phosphorylation of NFKB1 protein

PMID:15019085 PMID:15025948

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

increases phosphorylation

Hexachlorocyclohexane results in increased phosphorylation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NIPBL, cohesin loading factor

increases expression

Hexachlorocyclohexane results in increased expression of NIPBL mRNA

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

G

NOP58 ribonucleoprotein

increases expression

Hexachlorocyclohexane results in increased expression of NOL5 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

nitric oxide synthase 2

increases expression

Hexachlorocyclohexane results in increased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Hexachlorocyclohexane results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression
increases activity

Hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
Hexachlorocyclohexane results in increased expression of NR1I2 mRNA
Hexachlorocyclohexane results in increased activity of NR1I2 protein

PMID:14613717 PMID:15548381 PMID:16054614 PMID:25572523 PMID:25680588

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity

Hexachlorocyclohexane results in increased expression of NR1I3 mRNA
Hexachlorocyclohexane results in increased activity of NR1I3 protein

PMID:25572523 PMID:28927721

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 6

affects expression

Hexachlorocyclohexane affects the expression of NR2F6 mRNA

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

increases expression

Hexachlorocyclohexane results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

increases expression

Hexachlorocyclohexane results in increased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear respiratory factor 1

increases expression

Hexachlorocyclohexane results in increased expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

ornithine decarboxylase 1

multiple interactions
increases activity
increases expression

Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases expression

Hexachlorocyclohexane results in increased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

one cut homeobox 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

orthodenticle homeobox 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

Hexachlorocyclohexane results in decreased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

Parkinsonism associated deglycase

decreases activity

Hexachlorocyclohexane results in decreased activity of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

paired box 6

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

programmed cell death 4

increases expression

Hexachlorocyclohexane results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

platelet derived growth factor receptor beta

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

PDZ and LIM domain 1

decreases expression

Hexachlorocyclohexane results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

pellino E3 ubiquitin protein ligase 1

increases expression

Hexachlorocyclohexane results in increased expression of PELI1 mRNA

NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285

G

period circadian regulator 2

decreases expression

Hexachlorocyclohexane results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

phosphogluconate dehydrogenase

affects activity

Hexachlorocyclohexane affects the activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

progesterone receptor

affects binding
multiple interactions

Hexachlorocyclohexane binds to PGR protein
[Progesterone co-treated with Hexachlorocyclohexane] results in decreased expression of PGR mRNA; Hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Hexachlorocyclohexane inhibits the reaction [Progesterone binds to PGR protein]

PMID:9144411 PMID:14579009 PMID:26022396

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

polymeric immunoglobulin receptor

increases expression

Hexachlorocyclohexane results in increased expression of PIGR mRNA

NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875

G

praja ring finger ubiquitin ligase 2

increases expression

Hexachlorocyclohexane results in increased expression of PJA2 mRNA

NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783

G

phospholipase A and acyltransferase 5

decreases expression

Hexachlorocyclohexane results in decreased expression of PLAAT5 mRNA

NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184

G

phospholipase C-like 1

increases expression

Hexachlorocyclohexane results in increased expression of PLCL1 mRNA

NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782

G

phospholipid phosphatase 3

increases expression

Hexachlorocyclohexane results in increased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

plexin D1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

proline-rich nuclear receptor coactivator 1

increases expression

Hexachlorocyclohexane results in increased expression of PNRC1 mRNA

NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161

G

DNA polymerase gamma 2, accessory subunit

increases expression

Hexachlorocyclohexane results in increased expression of POLG2 mRNA

NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008

G

proopiomelanocortin

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

cytochrome p450 oxidoreductase

increases expression

Hexachlorocyclohexane results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

PPARG coactivator 1 alpha

increases expression

Hexachlorocyclohexane results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

Hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

PPARG related coactivator 1

increases expression

Hexachlorocyclohexane results in increased expression of PPRC1 mRNA

NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587

G

protein kinase cAMP-activated catalytic subunit beta

affects expression

Hexachlorocyclohexane affects the expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase C, eta

affects expression

Hexachlorocyclohexane affects the expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

peroxiredoxin like 2B

decreases expression

Hexachlorocyclohexane results in decreased expression of PRXL2B mRNA

NCBI chr 5:165,462,610...165,465,213

G

proteasome 20S subunit beta 3

decreases expression

Hexachlorocyclohexane results in decreased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Hexachlorocyclohexane results in increased expression of and results in increased activity of PTGS2 protein
Hexachlorocyclohexane results in increased expression of PTGS2 mRNA; Hexachlorocyclohexane results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase 4A1

increases expression

Hexachlorocyclohexane results in increased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

RAB14, member RAS oncogene family

increases expression

Hexachlorocyclohexane results in increased expression of RAB14 mRNA

NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172

G

RAB34, member RAS oncogene family

affects expression

Hexachlorocyclohexane affects the expression of RAB34 mRNA

NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

Hexachlorocyclohexane results in decreased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS like proto-oncogene A

increases expression

Hexachlorocyclohexane results in increased expression of RALA mRNA

NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063

G

Ral GTPase activating protein catalytic subunit alpha 1

increases expression

Hexachlorocyclohexane results in increased expression of RALGAPA1 mRNA

NCBI chr 6:72,977,432...73,252,378
Ensembl chr 6:72,977,432...73,252,378

G

retinoic acid receptor, alpha

increases activity

Hexachlorocyclohexane results in increased activity of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RB transcriptional corepressor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 10

decreases expression

Hexachlorocyclohexane results in decreased expression of RBM10 mRNA

NCBI chr X:1,540,399...1,572,571
Ensembl chr X:1,540,398...1,572,575

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
increases phosphorylation
affects localization

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein]
Hexachlorocyclohexane results in increased phosphorylation of RELA protein
Hexachlorocyclohexane affects the localization of RELA protein

PMID:15019085 PMID:15025948 PMID:19038305

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ret proto-oncogene

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

regulator of G-protein signaling 2

decreases expression

Hexachlorocyclohexane results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

arginyl aminopeptidase

decreases expression

Hexachlorocyclohexane results in decreased expression of RNPEP mRNA

NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998

G

ribosomal protein S15

decreases expression

Hexachlorocyclohexane results in decreased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

radical S-adenosyl methionine domain containing 2

decreases expression

Hexachlorocyclohexane results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

retinoid X receptor alpha

affects expression

Hexachlorocyclohexane affects the expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor beta

increases activity

Hexachlorocyclohexane results in increased activity of RXRB protein

NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773

G

retinoid X receptor gamma

decreases expression

Hexachlorocyclohexane results in decreased expression of RXRG mRNA

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

stearoyl-CoA desaturase

decreases expression

Hexachlorocyclohexane results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

syndecan 4

increases expression

Hexachlorocyclohexane results in increased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

SEC22 homolog A, vesicle trafficking protein

decreases expression

Hexachlorocyclohexane results in decreased expression of SEC22A mRNA

NCBI chr11:65,402,583...65,462,329
Ensembl chr11:65,402,684...65,462,319

G

SEC31 homolog A, COPII coat complex component

increases expression

Hexachlorocyclohexane results in increased expression of SEC31A mRNA

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

semaphorin 3G

decreases expression

Hexachlorocyclohexane results in decreased expression of SEMA3G mRNA

NCBI chr16:6,413,589...6,425,221
Ensembl chr16:6,413,589...6,425,221

G

serine incorporator 3

affects expression

Hexachlorocyclohexane affects the expression of SERINC3 mRNA

NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808

G

serpin family E member 2

decreases expression

Hexachlorocyclohexane results in decreased expression of SERPINE2 mRNA

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

sestrin 2

increases expression

Hexachlorocyclohexane results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

serum/glucocorticoid regulated kinase 1

decreases expression
increases expression

Hexachlorocyclohexane results in decreased expression of SGK1 mRNA
Hexachlorocyclohexane results in increased expression of SGK1 mRNA

PMID:17785943 PMID:24356939

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sex hormone binding globulin

multiple interactions
decreases expression

Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
Hexachlorocyclohexane results in decreased expression of SHBG protein

PMID:9171990 PMID:18248869

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

sucrase-isomaltase

decreases activity

Hexachlorocyclohexane results in decreased activity of SI protein

NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260

G

solute carrier family 10 member 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 11 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 22 member 1

decreases activity

Hexachlorocyclohexane results in decreased activity of SLC22A1 protein

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22, member 25

affects expression

Hexachlorocyclohexane affects the expression of SLC22A9 mRNA

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 25, member 30

decreases expression

Hexachlorocyclohexane results in decreased expression of SLC25A30 mRNA

NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613

G

solute carrier family 3 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

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solute carrier family 4 member 4

increases expression

Hexachlorocyclohexane results in increased expression of SLC4A4 mRNA

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 7 member 11

increases expression

Hexachlorocyclohexane results in increased expression of SLC7A11 mRNA

PMID:24356939 PMID:26198647

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

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solute carrier family 7 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

snail family transcriptional repressor 2

affects expression

Hexachlorocyclohexane affects the expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

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small nuclear ribonucleoprotein U1 subunit 70

increases expression

Hexachlorocyclohexane results in increased expression of SNRNP70 mRNA

NCBI chr 1:95,856,038...95,876,434
Ensembl chr 1:95,856,036...95,876,392

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suppressor of cytokine signaling 2

decreases expression

Hexachlorocyclohexane results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

sorbitol dehydrogenase

affects activity

Hexachlorocyclohexane affects the activity of SORD protein

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

sprouty RTK signaling antagonist 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SPRY1 mRNA

NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189

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squalene epoxidase

increases expression

Hexachlorocyclohexane results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sequestosome 1

increases expression

Hexachlorocyclohexane results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

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serine and arginine rich splicing factor 2

increases expression

Hexachlorocyclohexane results in increased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

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sulfiredoxin 1

increases expression

Hexachlorocyclohexane results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

signal transducing adaptor molecule 2

increases expression

Hexachlorocyclohexane results in increased expression of STAM2 mRNA

NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812

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steroidogenic acute regulatory protein

multiple interactions
decreases expression
increases expression

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]
Hexachlorocyclohexane results in decreased expression of STAR protein
Hexachlorocyclohexane results in increased expression of STAR protein
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]
Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]
Hexachlorocyclohexane results in increased expression of STAR mRNA

PMID:10993823 PMID:15749814 PMID:17080404 PMID:18248869

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

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sulfotransferase family 1A member 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

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sulfotransferase family 2A member 1

multiple interactions
decreases expression

Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]
Hexachlorocyclohexane results in decreased expression of SULT2A1 mRNA

PMID:9566755 PMID:17080404

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

transcription factor A, mitochondrial

increases expression

Hexachlorocyclohexane results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor B2, mitochondrial

increases expression

Hexachlorocyclohexane results in increased expression of TFB2M mRNA

NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657

G

transforming growth factor, beta 1

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tight junction protein 1

affects localization
multiple interactions
decreases expression

Hexachlorocyclohexane affects the localization of TJP1 protein
Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
Hexachlorocyclohexane results in decreased expression of TJP1 protein

PMID:11532877 PMID:15194225

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

multiple interactions
increases expression

[Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TLR4 protein
Hexachlorocyclohexane results in increased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane 6 superfamily member 1

increases expression

Hexachlorocyclohexane results in increased expression of TM6SF1 mRNA

NCBI chr 1:135,799,844...135,828,515
Ensembl chr 1:135,786,381...135,828,443

G

transmembrane and coiled-coil domains 6

decreases expression

Hexachlorocyclohexane results in decreased expression of TMCO6 mRNA

NCBI chr18:28,349,248...28,355,843
Ensembl chr18:28,349,248...28,355,843

G

transmembrane protein 177

decreases expression

Hexachlorocyclohexane results in decreased expression of TMEM177 mRNA

NCBI chr13:31,023,893...31,027,368
Ensembl chr13:31,023,455...31,027,378

G

transmembrane protein 267

increases expression

Hexachlorocyclohexane results in increased expression of TMEM267 mRNA

NCBI chr 2:51,580,210...51,588,937
Ensembl chr 2:51,581,252...51,587,636

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression

[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
[Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein
Lindane increases expression of Tnf protein in serum
Hexachlorocyclohexane results in increased expression of TNF mRNA; Hexachlorocyclohexane results in increased expression of TNF protein
Hexachlorocyclohexane results in decreased expression of TNF protein

CTD
RGD

PMID:15019085 PMID:15025948 PMID:15135310 PMID:15319175 PMID:28177269 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tenascin XA, pseudogene 1

affects expression

Hexachlorocyclohexane affects the expression of TNXA mRNA

NCBI chr20:4,026,471...4,027,826

G

torsin 1A interacting protein 1

increases expression

Hexachlorocyclohexane results in increased expression of TOR1AIP1 mRNA

NCBI chr13:68,196,681...68,226,121
Ensembl chr13:68,196,681...68,225,862

G

tumor protein p53

multiple interactions

[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 3

affects expression

Hexachlorocyclohexane affects the expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

transformer 2 beta

affects expression

Hexachlorocyclohexane affects the expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

tribbles pseudokinase 3

increases expression

Hexachlorocyclohexane results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tubulin, alpha 4A

decreases expression

Hexachlorocyclohexane results in decreased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

G

thioredoxin 2

decreases expression

Hexachlorocyclohexane results in decreased expression of TXN2 mRNA

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

TYRO3 protein tyrosine kinase

affects expression

Hexachlorocyclohexane affects the expression of TYRO3 mRNA

NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142

G

UDP glucuronosyltransferase family 1 member A1

increases activity

Hexachlorocyclohexane results in increased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Hexachlorocyclohexane results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

increases expression

Hexachlorocyclohexane results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide

decreases response to substance
multiple interactions

Hexachlorocyclohexane results in decreased susceptibility to VIP protein
Hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]

PMID:2467674 PMID:4120787 PMID:20732086

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

very low density lipoprotein receptor

increases expression

Hexachlorocyclohexane results in increased expression of VLDLR mRNA

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

WASP like actin nucleation promoting factor

increases expression

Hexachlorocyclohexane results in increased expression of WASL mRNA

NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022

G

zinc finger protein 354A

increases expression

Hexachlorocyclohexane results in increased expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 628

decreases expression

Hexachlorocyclohexane results in decreased expression of ZNF628 mRNA

NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
chemical entity	19878
molecular entity	19878
polyatomic entity	19830
heteroatomic molecular entity	19787
halide	18664
organohalogen compound	18528
halohydrocarbon	15851
chlorohydrocarbon	11880
chlorocycloalkane	513
chlorocyclohexane +	513
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
main group molecular entity	19817
s-block molecular entity	19653
hydrogen molecular entity	19634
hydrides	19144
organic hydride	18691
organic fundamental parent	18691
hydrocarbon	18442
halohydrocarbon	15851
chlorohydrocarbon	11880
chlorocycloalkane	513
chlorocyclohexane +	513

paths to the root