calcium ion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	calcium ion	go back to main search page
Accession:	CHEBI:39124	browse the term
Synonyms:	related_synonym:	Formula=Ca; calcium ions

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Rat (372 ) Mouse (371 ) Human (374 ) Chinchilla (0 ) Bonobo (0 ) Dog (3 ) Squirrel (0 ) Pig (2 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (374)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxymethylbilane synthase

decreases activity

ISO

Calcium ion decreases activity of purified Hmbs protein

RGD

NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834

atorvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression
multiple interactions
decreases expression

ISO
EXP

Atorvastatin results in increased expression of ABCA1 mRNA
[Rosiglitazone co-treated with Atorvastatin] results in increased expression of ABCA1 protein
Atorvastatin results in decreased expression of ABCA1 mRNA; Atorvastatin results in decreased expression of ABCA1 protein

PMID:15183127 PMID:16386711 PMID:25278499

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

multiple interactions
decreases expression
decreases activity
increases transport

EXP
ISO

ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Atorvastatin results in decreased expression of ABCB1A mRNA
Atorvastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Atorvastatin; ABCB1 protein results in increased transport of Atorvastatin analog

PMID:10751037 PMID:15616150 PMID:19802823 PMID:24502637

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

EXP

Atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; Atorvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atorvastatin results in decreased activity of ABCB11 protein

PMID:15901796 PMID:23956101 PMID:24014644

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 4

increases expression

ISO

Atorvastatin results in increased expression of ABCB4 mRNA; Atorvastatin results in increased expression of ABCB4 protein

PMID:15986414 PMID:25278499

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions
increases expression

EXP
ISO

Atorvastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Atorvastatin analog; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Atorvastatin results in increased expression of ABCC2 mRNA

PMID:15616150 PMID:23562342 PMID:25278499

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

increases expression

ISO

Atorvastatin results in increased expression of ABCC3 mRNA; Atorvastatin results in increased expression of ABCC3 protein

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily G member 2 (JR blood group)

increases expression

ISO

Atorvastatin results in increased expression of ABCG2 mRNA

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

ATP binding cassette subfamily G member 5

increases expression

ISO

Atorvastatin results in increased expression of ABCG5 mRNA

NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865

G

ATP binding cassette subfamily G member 8

increases expression

ISO

Atorvastatin results in increased expression of ABCG8 mRNA

NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988

G

acetyl-CoA carboxylase beta

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of ACACB mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ACACB mRNA]

NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226

G

angiotensin I converting enzyme

decreases expression

ISO

Atorvastatin results in decreased expression of ACE mRNA

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

angiotensin converting enzyme 2

increases expression

ISO

Atorvastatin results in increased expression of ACE2 mRNA

NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236

G

acyl-CoA oxidase 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA]

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

actin alpha 2, smooth muscle

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

ADAM metallopeptidase domain 12

decreases expression

ISO

Atorvastatin results in decreased expression of ADAM12 protein

NCBI chr10:126,012,391...126,388,477
Ensembl chr10:126,012,381...126,388,477

G

ADAM metallopeptidase domain 17

decreases expression

ISO

Atorvastatin results in decreased expression of ADAM17 protein

NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732

G

adhesion G protein-coupled receptor E1

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression

EXP
ISO

Atorvastatin results in decreased expression of ADIPOQ protein
Atorvastatin results in decreased expression of ADIPOQ mRNA
Atorvastatin results in increased expression of ADIPOQ protein

PMID:19651449 PMID:38971901

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

angiotensinogen

multiple interactions

ISO

Atorvastatin inhibits the reaction [AGT protein results in decreased expression of SOD1 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK1 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK3 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased expression of NOX1 protein]

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

aldo-keto reductase family 7 member A2

increases expression

EXP

Atorvastatin results in increased expression of AKR7A2 mRNA; Atorvastatin results in increased expression of AKR7A2 protein

NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

ISO
EXP

Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]
Atorvastatin results in increased phosphorylation of AKT1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; Atorvastatin results in decreased expression of and results in decreased phosphorylation of AKT1 protein

PMID:18172863 PMID:19526287 PMID:20305681 PMID:27345130 PMID:27815113 More...

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of ALPL mRNA]; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of ALPL protein]

NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410

G

angiopoietin 2

increases expression

EXP

Atorvastatin results in increased expression of ANGPT2 mRNA

NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409

G

apolipoprotein B

multiple interactions
decreases secretion
decreases expression

EXP
ISO

Atorvastatin results in decreased expression of and results in decreased secretion of APOB protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]
Atorvastatin results in decreased secretion of APOB protein
Atorvastatin results in decreased expression of APOB protein

PMID:9512650 PMID:10357840 PMID:11728391 PMID:12065722 PMID:12172771 More...

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

G

apolipoprotein E

decreases expression
multiple interactions

EXP
ISO

Atorvastatin results in decreased expression of APOE mRNA; Atorvastatin results in decreased expression of APOE protein
Atorvastatin affects the reaction [APOE protein affects the susceptibility to Dietary Fats]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein

PMID:16386711 PMID:19603250 PMID:32976958 PMID:36395561 PMID:37121058

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

amyloid beta precursor protein

multiple interactions

ISO

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]; Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein]

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

activating transcription factor 6

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

autophagy related 5

multiple interactions
increases response to substance

ISO

ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
ATG5 results in increased susceptibility to Atorvastatin

NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791

G

BCL2 antagonist/killer 1

increases expression

EXP

Atorvastatin results in increased expression of BAK1 protein

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

EXP
ISO

Atorvastatin results in increased expression of BAX protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]

PMID:19935899 PMID:37121058

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

EXP
ISO

Atorvastatin results in decreased expression of BCL2 mRNA; Atorvastatin results in decreased expression of BCL2 protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]

PMID:16470222 PMID:31423616 PMID:32259528 PMID:37121058

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

beclin 1

increases expression

ISO

Atorvastatin results in increased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

bone gamma-carboxyglutamate protein

increases expression

EXP

Atorvastatin results in increased expression of BGLAP mRNA

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

G

BH3 interacting domain death agonist

multiple interactions

ISO

Atorvastatin results in decreased expression of and results in increased cleavage of BID protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein]; U 0126 inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein]

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 5

decreases expression

ISO

Atorvastatin results in decreased expression of BIRC5 mRNA; Atorvastatin results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 2

increases expression
increases secretion

EXP
ISO

Atorvastatin results in increased expression of BMP2 mRNA
Atorvastatin results in increased secretion of BMP2 protein

PMID:16470222 PMID:17252541 PMID:38971901

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

complement C3

multiple interactions

ISO

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

caspase 1

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions
decreases activity
increases activity
increases cleavage

EXP
ISO

2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; RHOA protein inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]
Atorvastatin results in decreased activity of CASP3 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the cleavage of CASP3 protein; ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]

PMID:16470222 PMID:18172863 PMID:18339080 PMID:19429019 PMID:20305681 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions
increases activity

EXP
ISO

[Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]; [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]
Atorvastatin results in increased activity of CASP8 protein

PMID:15705602 PMID:18172863 PMID:20946910

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases activity

EXP
ISO

[Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]

PMID:15705602 PMID:16470222 PMID:18172863 PMID:18339080 PMID:29630879

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions
increases activity

ISO
EXP

Atorvastatin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
Atorvastatin results in increased activity of CAT protein

PMID:17479860 PMID:25218292

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

EXP
ISO

Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Atorvastatin results in decreased expression of and results in decreased secretion of CCL2 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CCL2 mRNA]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CCL2 protein]

PMID:12117737 PMID:25058445 PMID:34939712

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

CD14 molecule

decreases expression

EXP

Atorvastatin results in decreased expression of CD14 protein

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

G

CD36 molecule (CD36 blood group)

multiple interactions

EXP
ISO

Atorvastatin inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; Atorvastatin inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]

PMID:15183127 PMID:16386711 PMID:32259528

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD40 molecule

decreases expression

EXP

Atorvastatin results in decreased expression of CD40 protein

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

CD40 ligand

decreases expression

EXP

Atorvastatin results in decreased expression of CD40LG protein

PMID:16368305 PMID:19171469

NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390

G

CD83 molecule

decreases expression

EXP

Atorvastatin results in decreased expression of CD83 protein

NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,140,682

G

CD86 molecule

decreases expression

EXP

Atorvastatin results in decreased expression of CD86 protein

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

cell division cycle 42

multiple interactions

EXP

[Poly I-C co-treated with Atorvastatin] results in decreased expression of CDC42 mRNA

NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360

G

cadherin 1

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein]

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

EXP

[Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; CDKN1A protein mutant form inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
Atorvastatin results in increased expression of CDKN1A protein

PMID:18172863 PMID:20876807

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

cyclin dependent kinase inhibitor 1B

multiple interactions
increases expression

EXP

[Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1B protein
Atorvastatin results in increased expression of CDKN1B protein

PMID:16470222 PMID:18172863

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

CCAAT enhancer binding protein alpha

decreases expression

ISO

Atorvastatin results in decreased expression of CEBPA mRNA

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

CCAAT enhancer binding protein beta

increases expression

ISO

Atorvastatin results in increased expression of CEBPB mRNA

NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,734...50,192,690

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased phosphorylation of CHUK protein]

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

chloride voltage-gated channel 1

decreases expression

ISO

Atorvastatin results in decreased expression of CLCN1 protein

NCBI chr 7:143,316,111...143,352,083
Ensembl chr 7:143,316,111...143,352,083

G

collagen type I alpha 1 chain

increases expression
multiple interactions

EXP
ISO

Atorvastatin results in increased expression of COL1A1 mRNA
Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of COL1A1 mRNA]

PMID:17252541 PMID:38971901

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

carnitine palmitoyltransferase 1A

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of CPT1A mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased expression of CPT1A mRNA]

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

C-reactive protein

multiple interactions
decreases expression

EXP
ISO

[Atorvastatin co-treated with Amlodipine] results in decreased expression of CRP protein; Atorvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP mRNA]; Atorvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CRP protein]
Atorvastatin results in decreased expression of CRP protein

PMID:16025360 PMID:16360360 PMID:17673219 PMID:18389332 PMID:21584495 More...

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

citrate synthase

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of CS mRNA
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of CS mRNA]

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

G

colony stimulating factor 2

multiple interactions

EXP

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CSF2 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CSF2 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CSF2 protein]

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

catenin beta 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of CTNNB1 mRNA]

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

C-X-C motif chemokine ligand 10

decreases expression

ISO

Atorvastatin results in decreased expression of CXCL10

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 8

multiple interactions
increases expression
decreases secretion
decreases expression

EXP

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Atorvastatin results in decreased expression of and results in decreased secretion of CXCL8 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CXCL8 mRNA]
Atorvastatin results in increased expression of CXCL8 protein
Atorvastatin results in decreased secretion of CXCL8 protein
Atorvastatin results in decreased expression of CXCL8 mRNA; Atorvastatin results in decreased expression of CXCL8 protein

PMID:12117737 PMID:16387846 PMID:16410222 PMID:19171469 PMID:19482827

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

cytochrome b-245 alpha chain

multiple interactions

ISO

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA]

NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083

G

cytochrome c, somatic

multiple interactions
affects localization

ISO
EXP

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the localization of CYCS protein]

PMID:31423616 PMID:32259528

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 11 subfamily A member 1

affects expression

ISO

Atorvastatin affects the expression of CYP11A1 mRNA

NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646

G

cytochrome P450 family 17 subfamily A member 1

increases expression

ISO

Atorvastatin results in increased expression of CYP17A1 mRNA

NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472

G

cytochrome P450 family 19 subfamily A member 1

increases expression

ISO

Atorvastatin results in increased expression of CYP19A1 mRNA

NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601

G

cytochrome P450 family 27 subfamily A member 1

decreases expression
increases expression

EXP
ISO

Atorvastatin results in decreased expression of CYP27A1 mRNA; Atorvastatin results in decreased expression of CYP27A1 protein
Atorvastatin results in increased expression of CYP27A1 mRNA

PMID:16386711 PMID:25278499

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

G

cytochrome P450 family 2 subfamily B member 6

increases expression

EXP
ISO

Atorvastatin results in increased expression of CYP2B6 mRNA
Atorvastatin results in increased expression of CYP2B10 mRNA; Atorvastatin results in increased expression of CYP2B10 protein

PMID:15802384 PMID:15986414

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 39 subfamily A member 1

increases expression

ISO

Atorvastatin results in increased expression of CYP39A1 mRNA

NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830

G

cytochrome P450 family 3 subfamily A member 4

increases expression
multiple interactions
decreases expression
decreases activity
affects metabolic processing
affects response to substance
increases metabolic processing

EXP
ISO

Atorvastatin results in increased expression of CYP3A4 protein
Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]
Atorvastatin results in decreased expression of CYP3A4 mRNA; Atorvastatin results in decreased expression of CYP3A4 protein
CYP3A4 protein affects the metabolism of Atorvastatin
CYP3A4 polymorphism affects the susceptibility to Atorvastatin
CYP3A4 protein results in increased metabolism of Atorvastatin
ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin]; Atorvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]

PMID:15963098 PMID:16011971 PMID:16029222 PMID:18528690 PMID:18846481 More...

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 3 subfamily A member 51, pseudogene

affects response to substance

EXP

CYP3A51P gene polymorphism affects the susceptibility to Atorvastatin

NCBI chr 7:99,685,024...99,700,120
Ensembl chr 7:99,685,145...99,700,034

G

cytochrome P450 family 7 subfamily A member 1

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of CYP7A1 mRNA
Atorvastatin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]

PMID:25278499 PMID:32048413

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

ISO

Atorvastatin results in decreased expression of CYP7B1 mRNA

NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737

G

doublecortin

increases expression

ISO

Atorvastatin results in increased expression of DCX protein

NCBI chr X:111,293,779...111,412,192
Ensembl chr X:111,293,779...111,412,429

G

diacylglycerol O-acyltransferase 1

increases expression
multiple interactions
increases activity

ISO

Atorvastatin results in increased expression of DGAT1 mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of DGAT1 protein]

NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910

G

DNA replication and sister chromatid cohesion 1

affects response to substance

EXP

DSCC1 protein affects the susceptibility to Atorvastatin

NCBI chr 8:119,833,976...119,855,894
Ensembl chr 8:119,833,976...119,855,894

G

endothelin 1

decreases expression

EXP

Atorvastatin results in decreased expression of EDN1 protein

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin receptor type A

multiple interactions
decreases expression

ISO

Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA]

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

epidermal growth factor receptor

multiple interactions

ISO

Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases response to substance

EXP

EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]
EIF2AK3 results in increased susceptibility to Atorvastatin

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

EXP

4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

erythrocyte membrane protein band 4.1

multiple interactions

ISO

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in decreased expression of EPB41 protein]

NCBI chr 1:28,887,100...29,120,041
Ensembl chr 1:28,887,091...29,120,046

G

coagulation factor II, thrombin

decreases activity

EXP

Atorvastatin results in decreased activity of F2 protein

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor V

decreases activity

EXP

Atorvastatin results in decreased activity of F5 protein

NCBI chr 1:169,511,951...169,586,481
Ensembl chr 1:169,511,951...169,586,588

G

Fas associated via death domain

multiple interactions

ISO

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

affects expression

ISO

Atorvastatin affects the expression of FAS mRNA; Atorvastatin affects the expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

multiple interactions
increases expression

ISO
EXP

[Atorvastatin co-treated with Acetylcysteine] inhibits the reaction [sodium arsenite results in increased expression of FASLG protein]
Atorvastatin results in increased expression of FASLG protein modified form
Atorvastatin inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of FASLG protein modified form]

PMID:15063428 PMID:20946910

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fatty acid synthase

increases expression
multiple interactions

EXP
ISO

Atorvastatin results in increased expression of FASN mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA]

PMID:11728391 PMID:12056585 PMID:32259528

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

F-box protein 32

increases expression

ISO

Atorvastatin results in increased expression of FBXO32 mRNA

NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206

G

fibroblast growth factor 19

decreases expression

ISO

Atorvastatin results in decreased expression of FGF15 mRNA

NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022

G

forkhead box O1

decreases phosphorylation

ISO

Atorvastatin results in decreased phosphorylation of FOXO1 protein

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

ferritin heavy chain 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

G

frizzled class receptor 5

decreases expression

ISO

Atorvastatin results in decreased expression of FZD5 mRNA

NCBI chr 2:207,762,598...207,769,906
Ensembl chr 2:207,762,598...207,769,906

G

frizzled class receptor 8

decreases expression

ISO

Atorvastatin results in decreased expression of FZD8 mRNA

NCBI chr10:35,638,247...35,642,296
Ensembl chr10:35,638,247...35,642,296

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

glucokinase

decreases expression
multiple interactions

EXP
ISO

Atorvastatin results in decreased expression of GCK protein
NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of GCK protein]

NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170

G

gap junction protein alpha 1

multiple interactions

ISO

Atorvastatin promotes the reaction [dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein]]

NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727

G

G protein subunit gamma 3

multiple interactions
affects localization

ISO

[Isoproterenol co-treated with Atorvastatin] affects the localization of GNG3 protein
Atorvastatin affects the localization of GNG3 protein

NCBI chr11:62,706,446...62,709,201
Ensembl chr11:62,707,676...62,709,201

G

glutamic-oxaloacetic transaminase 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GOT1 protein]

NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA]

NCBI chr10:112,149,865...112,227,677
Ensembl chr10:112,149,865...112,215,377

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
[Atorvastatin co-treated with triptolide] results in increased expression of GPT protein; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GPT protein]

PMID:29679711 PMID:30657622 PMID:32259528 PMID:32976958 PMID:33600922 More...

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 4

multiple interactions

ISO

Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]

NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791

G

heparin binding EGF like growth factor

decreases expression

ISO

Atorvastatin results in decreased expression of HBEGF protein

NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
affects binding
increases expression
increases activity

EXP
ISO

Atorvastatin results in increased expression of and results in increased activity of HMGCR protein
Atorvastatin binds to HMGCR protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Atorvastatin results in increased expression of and results in increased activity of HMGCR protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]

PMID:9512650 PMID:10357840 PMID:12056585 PMID:12065722 PMID:12612140 More...

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

heme oxygenase 1

increases expression
multiple interactions

EXP
ISO

Atorvastatin results in increased expression of HMOX1 mRNA
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]

PMID:16410222 PMID:32259528 PMID:32976958 PMID:38484826

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hepatocyte nuclear factor 4 alpha

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA]

NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845

G

5-hydroxytryptamine receptor 7

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of HTR7 mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of HTR7 mRNA]]

NCBI chr10:90,740,823...90,858,039
Ensembl chr10:90,740,823...90,858,039

G

intercellular adhesion molecule 1

multiple interactions
increases expression

EXP
ISO

Atorvastatin inhibits the reaction [TNF results in increased expression of ICAM1]
Atorvastatin results in increased expression of ICAM1 protein
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of ICAM1 protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]

PMID:12615677 PMID:17589825 PMID:19171469 PMID:25058445

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased phosphorylation of IKBKB protein]

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

interleukin 12A

decreases expression

EXP

Atorvastatin results in decreased expression of IL12A mRNA

NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019

G

interleukin 18

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096

G

interleukin 1 beta

multiple interactions

EXP
ISO

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]

PMID:17589825 PMID:19482827 PMID:25058445 PMID:32048413 PMID:34939712 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2 receptor subunit alpha

affects expression

EXP

Atorvastatin affects the expression of IL2RA protein

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 6

multiple interactions
decreases expression
decreases secretion

EXP
ISO

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Atorvastatin results in decreased expression of and results in decreased secretion of IL6 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of IL6 mRNA]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of IL6 protein]
Atorvastatin results in decreased expression of IL6 mRNA; Atorvastatin results in decreased expression of IL6 protein
Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of IL6 mRNA]]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of IL6 mRNA]]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
Atorvastatin results in decreased secretion of IL6 protein

PMID:12117737 PMID:16387846 PMID:17521631 PMID:19171469 PMID:19482827 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

insulin

increases expression

EXP

Atorvastatin results in increased expression of INS protein

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

INS-IGF2 readthrough

multiple interactions

ISO

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of INS1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]

PMID:19800637 PMID:34939712

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

interleukin 1 receptor associated kinase 1

multiple interactions

EXP

[Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA

NCBI chr X:154,010,507...154,019,902
Ensembl chr X:154,010,506...154,019,902

G

interferon regulatory factor 4

decreases expression

ISO

Atorvastatin results in decreased expression of IRF4 protein

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

integrin subunit alpha 2

multiple interactions

EXP
ISO

Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]; geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]

NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779

G

integrin subunit alpha L

multiple interactions

EXP

Atorvastatin inhibits the reaction [TNF results in increased expression of ITGAL]

NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567

G

integrin subunit alpha M

decreases expression

EXP

Atorvastatin results in decreased expression of ITGAM protein

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

integrin subunit alpha X

decreases expression

EXP

Atorvastatin results in decreased expression of ITGAX protein

NCBI chr16:31,355,176...31,382,999
Ensembl chr16:31,355,134...31,382,999

G

integrin subunit beta 1

multiple interactions
increases expression

EXP
ISO

Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]; geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ITGB1 mRNA]

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 2

multiple interactions

EXP

Atorvastatin inhibits the reaction [TNF results in increased expression of ITGB2]

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[Atorvastatin co-treated with Celecoxib] results in increased expression of JUN protein; Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein; Celecoxib promotes the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions

ISO

Atorvastatin results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

ketohexokinase

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]

NCBI chr 2:27,086,772...27,100,762
Ensembl chr 2:27,086,772...27,100,762

G

kinesin family member 6

increases response to substance

EXP

KIF6 polymorphism results in increased susceptibility to Atorvastatin

NCBI chr 6:39,329,990...39,725,408
Ensembl chr 6:39,329,990...39,725,408

G

karyopherin subunit alpha 2

multiple interactions
affects localization

EXP

[Ivermectin co-treated with Atorvastatin] affects the localization of KPNA2 protein
Atorvastatin affects the localization of KPNA2 protein

NCBI chr17:68,035,735...68,046,854
Ensembl chr17:68,035,636...68,047,364

G

karyopherin subunit alpha 7

multiple interactions

EXP

Atorvastatin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA]

NCBI chr 7:99,145,804...99,219,419
Ensembl chr 7:99,173,572...99,250,075

G

lecithin-cholesterol acyltransferase

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein]

NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131

G

lipocalin 2

multiple interactions

ISO

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]

PMID:29679711 PMID:32259528

NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453

G

low density lipoprotein receptor

increases activity
multiple interactions
increases expression

EXP
ISO

Atorvastatin results in increased activity of LDLR protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Atorvastatin inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]
Atorvastatin results in increased expression of LDLR mRNA

PMID:10357840 PMID:11728391 PMID:12612140 PMID:24502637 PMID:30273964 More...

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

leptin

multiple interactions

ISO

Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

lipoprotein lipase

multiple interactions
increases expression

ISO

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]; Atorvastatin inhibits the reaction [Dexamethasone results in increased expression of LPL mRNA]
Atorvastatin results in increased expression of LPL mRNA

PMID:30273964 PMID:38971901

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

LDL receptor related protein 5

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of LRP5 mRNA]

NCBI chr11:68,298,412...68,449,275
Ensembl chr11:68,312,591...68,449,275

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased lipidation of MAP1LC3B protein]

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

EXP
ISO

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]
Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]
Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:16470222 PMID:18339080 PMID:18360054 PMID:19451411

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

multiple interactions

ISO
EXP

Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
Atorvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK14 protein]

PMID:17589825 PMID:19767766 PMID:20018284 PMID:20305681

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]
Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]
Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:16470222 PMID:18339080 PMID:18360054 PMID:19451411

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of MAPK8 mRNA]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of MAPK9 mRNA]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

myoglobin

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of MB protein
[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein

PMID:27815113 PMID:29679711

NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

EXP

Atorvastatin results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

MDM2 proto-oncogene

increases expression

EXP

Atorvastatin results in increased expression of MDM2 protein

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

myocyte enhancer factor 2D

increases expression

ISO

Atorvastatin results in increased expression of MEF2D mRNA

NCBI chr 1:156,463,727...156,500,775
Ensembl chr 1:156,463,727...156,500,779

G

mitofusin 2

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 protein]

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

microRNA 133b

multiple interactions

ISO

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA

NCBI chr 6:52,148,923...52,149,041
Ensembl chr 6:52,148,923...52,149,041

G

microRNA 145

increases expression

EXP

Atorvastatin results in increased expression of MIR145 mRNA

NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733

G

microRNA 146a

multiple interactions

EXP

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A; [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A

NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450

G

microRNA 146b

multiple interactions

EXP

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B; [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B

NCBI chr10:102,436,512...102,436,584
Ensembl chr10:102,436,512...102,436,584

G

microRNA 206

multiple interactions

ISO

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA

NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434

G

microRNA 221

decreases expression

EXP

Atorvastatin results in decreased expression of MIR221

NCBI chr X:45,746,157...45,746,266
Ensembl chr X:45,746,157...45,746,266

G

microRNA 222

decreases expression

EXP

Atorvastatin results in decreased expression of MIR222

NCBI chr X:45,747,015...45,747,124
Ensembl chr X:45,747,015...45,747,124

G

MLX interacting protein like

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]

PMID:19053045 PMID:21122807

NCBI chr 7:73,593,202...73,647,907
Ensembl chr 7:73,593,194...73,624,543

G

matrix metallopeptidase 2

decreases expression
increases activity

ISO

Atorvastatin results in decreased expression of MMP2 protein
Atorvastatin results in increased activity of MMP2 protein

PMID:18360054 PMID:23831763

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions
increases activity

EXP
ISO

Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sildenafil Citrate promotes the reaction [Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]]
Atorvastatin results in increased activity of MMP9 protein

PMID:15728660 PMID:23831763 PMID:26614570

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions

ISO

Atorvastatin inhibits the reaction [Paraquat results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

macrophage scavenger receptor 1

multiple interactions

EXP

[Rosiglitazone co-treated with Atorvastatin] results in increased expression of MSR1 mRNA

NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490

G

myostatin

increases expression

ISO

Atorvastatin results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

mitochondrially encoded cytochrome c oxidase I

affects expression
multiple interactions

ISO

Atorvastatin affects the expression of COX1 mRNA
Quercetin inhibits the reaction [Atorvastatin affects the expression of COX1 mRNA]

NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445

G

metallothionein 2A

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA]

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of and results in increased phosphorylation of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

microsomal triglyceride transfer protein

increases expression
multiple interactions
decreases expression

ISO
EXP

Atorvastatin results in increased expression of MTTP mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of MTTP mRNA]
Atorvastatin results in decreased expression of MTTP mRNA

PMID:10357840 PMID:12056585

NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

EXP

Atorvastatin results in decreased expression of MYC mRNA

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

MYD88 innate immune signal transduction adaptor

multiple interactions

ISO

Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of MYD88 mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of MYD88 protein]

NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024

G

myosin heavy chain 2

multiple interactions
affects expression

ISO

[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of MYH2 protein
Atorvastatin affects the expression of MYH2 protein

NCBI chr17:10,521,148...10,549,658
Ensembl chr17:10,521,148...10,549,700

G

NFE2 like bZIP transcription factor 1

increases expression

ISO

Atorvastatin results in increased expression of NFE2L1 mRNA

NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions
decreases expression

ISO
EXP

Atorvastatin results in increased expression of NFE2L2 mRNA
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of NFE2L2 protein]; Atorvastatin results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of NFE2L2 mRNA; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]

PMID:30511338 PMID:31423616 PMID:32259528 PMID:32976958 PMID:38484826

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

multiple interactions

EXP
ISO

[Ivermectin co-treated with Atorvastatin] inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Atorvastatin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:34696514 PMID:37023836

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NLR family pyrin domain containing 3

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

PMID:34939712 PMID:37023836

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108

G

nicotinamide N-methyltransferase

increases expression

EXP

Atorvastatin results in increased expression of NNMT protein

NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Atorvastatin results in decreased expression of NOS2 mRNA; Atorvastatin results in decreased expression of NOS2 protein

PMID:15166393 PMID:25058445 PMID:25218292

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions
increases expression
affects response to substance

EXP
ISO

Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]]
Atorvastatin results in increased expression of NOS3 mRNA; Atorvastatin results in increased expression of NOS3 protein
[Dexamethasone co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; [Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased phosphorylation of NOS3 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS3 protein]; Atorvastatin inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]
NOS3 promoter SNP affects the susceptibility to Atorvastatin

PMID:12490971 PMID:15166393 PMID:16410222 PMID:16962929 PMID:17042910 More...

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

NADPH oxidase 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [AGT protein results in increased expression of NOX1 protein]

NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359

G

NADPH oxidase 4

multiple interactions

ISO
EXP

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOX4 mRNA]
Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]

PMID:20018284 PMID:25218292

NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187

G

natriuretic peptide A

multiple interactions

ISO

Atorvastatin inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

decreases expression

ISO

Atorvastatin results in decreased expression of NPPB protein

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

nuclear receptor subfamily 0 group B member 2

decreases expression

ISO

Atorvastatin results in decreased expression of NR0B2 mRNA

NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975

G

nuclear receptor subfamily 1 group I member 2

multiple interactions
increases expression

EXP
ISO

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Atorvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of GCK protein]; NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of SLC2A2 protein]
Atorvastatin promotes the reaction [Dietary Fats results in increased expression of NR1I2 protein]
Atorvastatin binds to and results in increased activity of NR1I2 protein
Atorvastatin results in increased expression of NR1I2 protein

PMID:15986414 PMID:24204015 PMID:26616219

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

nuclear receptor subfamily 1 group I member 3

increases activity

EXP
ISO

Atorvastatin results in increased activity of NR1I3 protein

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

G

nuclear respiratory factor 1

multiple interactions
affects expression
increases expression

ISO

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of NRF1 mRNA]; Quercetin inhibits the reaction [Atorvastatin affects the expression of NRF1 mRNA]

NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage

EXP
ISO

2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; CDKN1A protein mutant form inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]

PMID:16470222 PMID:18172863 PMID:20876807 PMID:31423616

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

phosphate cytidylyltransferase 1A, choline

increases activity

ISO

Atorvastatin results in increased activity of PCYT1A protein

NCBI chr 3:196,234,368...196,287,726
Ensembl chr 3:196,214,222...196,287,957

G

pyruvate dehydrogenase kinase 4

multiple interactions

ISO

Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]

NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516

G

3-phosphoinositide dependent protein kinase 1

multiple interactions

EXP

[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of and results in decreased expression of PDPK1 protein

NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,190

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

decreases expression

EXP

Atorvastatin results in decreased expression of PIK3CA mRNA

NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093

G

pyruvate kinase L/R

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]

PMID:19053045 PMID:21122807

NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438

G

pyruvate kinase M1/2

increases expression

ISO

Atorvastatin results in increased expression of PKM mRNA

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

plasminogen activator, urokinase

decreases expression

EXP

Atorvastatin results in decreased expression of PLAU protein

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

perilipin 2

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PLIN2 protein]

NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290

G

proopiomelanocortin

increases expression

ISO

Atorvastatin results in increased expression of POMC protein

NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903

G

paraoxonase 1

increases activity
multiple interactions
increases expression

EXP
ISO

Atorvastatin results in increased activity of PON1 protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]
PON1 gene polymorphism affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]; PON1 gene SNP affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]; PON1 protein affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]
Atorvastatin results in increased expression of PON1 mRNA

PMID:15324535 PMID:15690306 PMID:15969877 PMID:16238680 PMID:30273964

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

paraoxonase 2

increases activity
increases expression

EXP

Atorvastatin results in increased activity of PON2 protein
Atorvastatin results in increased expression of PON2 mRNA

NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

EXP
ISO

Atorvastatin results in decreased expression of PPARA mRNA
Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]

PMID:12065722 PMID:18812576 PMID:21554872 PMID:32259528

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

peroxisome proliferator activated receptor gamma

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
Atorvastatin inhibits the reaction [Dexamethasone results in increased expression of PPARG mRNA]; Atorvastatin inhibits the reaction [Dexamethasone results in increased expression of PPARG protein]

PMID:36006763 PMID:38971901

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

PPARG coactivator 1 alpha

decreases expression
affects expression
multiple interactions
increases expression

ISO

Atorvastatin results in decreased expression of PPARGC1A mRNA
Atorvastatin results in decreased expression of PPARGC1A protein
Atorvastatin affects the expression of PPARGC1A mRNA
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1A mRNA
Atorvastatin results in increased expression of PPARGC1A mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of PPARGC1A mRNA]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]; Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]

PMID:21775390 PMID:22343369 PMID:30511338 PMID:32259528

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

PPARG coactivator 1 beta

affects expression
decreases expression
affects response to substance
multiple interactions

ISO

Atorvastatin affects the expression of PPARGC1B mRNA
Atorvastatin affects the expression of PPARGC1B protein
Atorvastatin results in decreased expression of PPARGC1B mRNA
PPARGC1B protein affects the susceptibility to Atorvastatin
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the cleavage of CASP3 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of MYH2 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of NFE2L2 mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1A mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1B mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of SOD2 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TFAM mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TOMM20 protein
Quercetin inhibits the reaction [Atorvastatin affects the expression of PPARGC1B mRNA]

PMID:21775390 PMID:30511338

NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022

G

protein phosphatase 3 catalytic subunit alpha

increases expression

ISO

Atorvastatin results in increased expression of PPP3CA mRNA

NCBI chr 4:101,023,418...101,347,526
Ensembl chr 4:101,023,409...101,348,278

G

protein kinase AMP-activated catalytic subunit alpha 1

increases activity

EXP

Atorvastatin results in increased activity of PRKAA1 protein

NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

ISO

Atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein]

NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084

G

protein kinase C alpha

multiple interactions

ISO

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C theta

increases expression

ISO

Atorvastatin results in increased expression of PRKCQ mRNA; Atorvastatin results in increased expression of PRKCQ protein

NCBI chr10:6,394,097...6,580,646
Ensembl chr10:6,427,143...6,580,301

G

protein kinase C zeta

multiple interactions

ISO

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]

NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395

G

phosphatase and tensin homolog

increases expression

ISO

Atorvastatin results in increased expression of PTEN protein

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

ISO

[Atorvastatin co-treated with Pioglitazone] results in increased expression of PTGS2 protein; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PTGS2 protein]
Atorvastatin results in increased expression of PTGS2 protein

PMID:16908763 PMID:34939712

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

Rac family small GTPase 1

multiple interactions

EXP
ISO

[Poly I-C co-treated with Atorvastatin] results in decreased expression of RAC1 mRNA; Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of RAC1 protein]
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of and results in increased localization of RAC1 protein]

PMID:17279352 PMID:17589825 PMID:34696514

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

RB transcriptional corepressor 1

multiple interactions

EXP

[Atorvastatin co-treated with Celecoxib] results in decreased expression of RB1 protein modified form; [Atorvastatin co-treated with Celecoxib] results in increased expression of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of RELA protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of RELA mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of RELA protein]; Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]

PMID:19733216 PMID:34939712 PMID:37121058 PMID:38213245

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ras homolog family member A

increases expression
decreases activity
multiple interactions
decreases localization

EXP
ISO

Atorvastatin results in increased expression of RHOA protein
Atorvastatin results in decreased activity of RHOA protein
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of RHOA protein]
[Poly I-C co-treated with Atorvastatin co-treated with Ivermectin] results in increased expression of RHOA mRNA; [Poly I-C co-treated with Atorvastatin] results in increased expression of RHOA mRNA; Atorvastatin results in increased localization of and results in decreased prenylation of RHOA protein; Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; RHOA protein inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]

PMID:16470222 PMID:17589825 PMID:18172863 PMID:34696514

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member B

increases localization
increases expression
multiple interactions

EXP

Atorvastatin results in increased localization of RHOB protein
Atorvastatin results in increased expression of RHOB protein
[Atorvastatin co-treated with Celecoxib] results in increased localization of RHOB protein; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOB protein]

NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440

G

ras homolog family member C

decreases localization
multiple interactions
increases expression

EXP

Atorvastatin results in decreased localization of RHOC protein
Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOC protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOC protein]

NCBI chr 1:112,701,131...112,707,408
Ensembl chr 1:112,701,127...112,707,434

G

ribosomal protein L36a

increases expression

ISO

Atorvastatin results in increased expression of CYP21A2 mRNA

NCBI chr X:101,391,011...101,396,155
Ensembl chr X:101,390,824...101,396,155

G

RUNX family transcription factor 2

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

scavenger receptor class B member 1

multiple interactions

EXP

[Rosiglitazone co-treated with Atorvastatin] results in increased expression of SCARB1 protein

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

stearoyl-CoA desaturase

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]

NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826

G

selectin E

increases expression

EXP

Atorvastatin results in increased expression of SELE protein

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

serpin family E member 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

serum/glucocorticoid regulated kinase 2

multiple interactions

EXP

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA

NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237

G

sirtuin 1

multiple interactions
increases phosphorylation

ISO
EXP

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]
Atorvastatin results in increased phosphorylation of SIRT1 protein

PMID:33073877 PMID:34939712

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

solute carrier family 10 member 1

increases expression

ISO

Atorvastatin results in increased expression of SLC10A1 mRNA

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 10 member 2

increases expression

ISO

Atorvastatin results in increased expression of SLC10A2 mRNA; Atorvastatin results in increased expression of SLC10A2 protein

NCBI chr13:103,043,998...103,066,417
Ensembl chr13:103,043,998...103,066,417

G

solute carrier family 1 member 2

multiple interactions

ISO

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]

NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063

G

solute carrier family 1 member 3

multiple interactions

ISO

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein]

NCBI chr 5:36,606,606...36,688,334
Ensembl chr 5:36,596,588...36,688,334

G

solute carrier family 22 member 1

multiple interactions
increases expression

EXP
ISO

Atorvastatin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Atorvastatin results in increased expression of SLC22A1 mRNA

PMID:21641380 PMID:25278499

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 3

multiple interactions

EXP

Atorvastatin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 22 member 5

multiple interactions

EXP

Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613

G

solute carrier family 29 member 1 (Augustine blood group)

increases expression

ISO

Atorvastatin results in increased expression of SLC29A1 mRNA

NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142

G

solute carrier family 2 member 2

decreases expression
multiple interactions

ISO
EXP

Atorvastatin results in decreased expression of SLC2A2 protein
NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of SLC2A2 protein]

NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743

G

solute carrier family 2 member 4

multiple interactions

ISO

Atorvastatin inhibits the reaction [Sodium Glutamate results in decreased expression of SLC2A4 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in decreased expression of SLC2A4 protein]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of SLC2A4 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of SLC2A4 protein]

PMID:19800637 PMID:25834641

NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257

G

solute carrier family 4 member 1 (Diego blood group)

multiple interactions

ISO

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]

NCBI chr17:44,248,390...44,268,135
Ensembl chr17:44,248,390...44,268,141

G

solute carrier family 6 member 4

multiple interactions

ISO

Atorvastatin inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 protein]

NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002

G

solute carrier organic anion transporter family member 1A2

decreases expression

ISO

Atorvastatin results in decreased expression of SLCO1A4 protein

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

solute carrier organic anion transporter family member 1B1

decreases activity
increases uptake
increases import
decreases transport
multiple interactions

EXP

Atorvastatin results in decreased activity of SLCO1B1 protein
SLCO1B1 protein results in increased uptake of Atorvastatin
SLCO1B1 protein results in increased import of Atorvastatin
SLCO1B1 gene SNP results in decreased transport of Atorvastatin
Apigenin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin]; Atorvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]; glimepiride inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Glyburide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; kaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Pioglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Quercetin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin]; repaglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Rosiglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]

PMID:15616150 PMID:15970799 PMID:22394605 PMID:23121773 PMID:25106415 More...

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

G

solute carrier organic anion transporter family member 1B3

increases expression
increases uptake
multiple interactions

ISO
EXP

Atorvastatin results in increased expression of SLCO1B2 mRNA
SLCO1B3 protein results in increased uptake of Atorvastatin
glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Rosiglitazone inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]

PMID:23121773 PMID:25106415 PMID:25278499

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

solute carrier organic anion transporter family member 2B1

multiple interactions
increases uptake

EXP

glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Rosiglitazone inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]

PMID:23121773 PMID:25106415

NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549

G

superoxide dismutase 1

multiple interactions

ISO

Atorvastatin inhibits the reaction [AGT protein results in decreased expression of SOD1 protein]

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

multiple interactions
affects expression
decreases expression
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of SOD2 mRNA]; Quercetin affects the reaction [Atorvastatin affects the expression of SOD2 mRNA]
Atorvastatin affects the expression of SOD2 protein
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the expression of SOD2 protein]
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of SOD2 protein
Atorvastatin results in decreased expression of SOD2 protein

PMID:21775390 PMID:30511338 PMID:31423616

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

superoxide dismutase 3

increases expression

ISO

Atorvastatin results in increased expression of SOD3 protein

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

G

Sp7 transcription factor

multiple interactions

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of SP7 protein]

NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315

G

sequestosome 1

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]

PMID:19053045 PMID:32259528

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression
increases localization

ISO
EXP

Atorvastatin results in increased activity of and results in increased localization of SREBF2 protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA]
Atorvastatin results in increased localization of SREBF2 protein

PMID:11728391 PMID:12056585 PMID:12065722

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

G

steroidogenic acute regulatory protein

affects expression

ISO

Atorvastatin affects the expression of STAR mRNA

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

synaptophysin

increases expression

ISO

Atorvastatin results in increased expression of SYP protein

NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218

G

transcription factor A, mitochondrial

increases expression
decreases expression
multiple interactions

ISO

Atorvastatin results in increased expression of TFAM mRNA
Atorvastatin results in decreased expression of TFAM protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TFAM mRNA
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of TFAM mRNA]

PMID:21775390 PMID:30511338

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

G

transferrin receptor

affects expression
multiple interactions

EXP
ISO

Atorvastatin affects the expression of TFRC protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]

PMID:16387846 PMID:32976958

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

transforming growth factor beta 1

multiple interactions

ISO

2-chloro-5-nitrobenzanilide inhibits the reaction [Atorvastatin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]

PMID:24161914 PMID:32329363

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

decreases expression

ISO

Atorvastatin results in decreased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta 3

decreases expression

ISO

Atorvastatin results in decreased expression of TGFB3 mRNA

NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011

G

thrombospondin 1

decreases expression

EXP

Atorvastatin results in decreased expression of THBS1 mRNA

NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466

G

toll like receptor 2

increases expression

EXP

Atorvastatin results in increased expression of TLR2 protein

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260

G

toll like receptor 4

multiple interactions
decreases expression
increases expression

EXP
ISO

[Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein
Atorvastatin results in decreased expression of TLR4 mRNA; Atorvastatin results in decreased expression of TLR4 protein
Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 protein]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein]
Atorvastatin results in increased expression of TLR4 protein

PMID:16387846 PMID:20524934 PMID:27883937 PMID:38213245

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions
decreases expression
decreases secretion

EXP
ISO

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of FASLG protein modified form]; Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of ITGAL]; Atorvastatin inhibits the reaction [TNF results in increased expression of ITGB2]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of TNF mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of TNF mRNA]]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]; Atorvastatin inhibits the reaction [TNF protein results in increased oxidation of Glucose]; Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]
Atorvastatin results in decreased expression of TNF mRNA
Atorvastatin results in decreased secretion of TNF protein
Atorvastatin results in decreased expression of TNF protein

PMID:12117737 PMID:12615677 PMID:15063428 PMID:16387846 PMID:17521631 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 11b

multiple interactions
increases expression

ISO

Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]
Atorvastatin results in increased expression of TNFRSF11B mRNA

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF receptor superfamily member 1A

decreases expression

EXP

Atorvastatin results in decreased expression of TNFRSF1A protein

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF superfamily member 10

increases response to substance

EXP

TNFSF10 protein results in increased susceptibility to Atorvastatin

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

translocase of outer mitochondrial membrane 20

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of TOMM20 protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TOMM20 protein

NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837

G

tumor protein p53

increases expression
multiple interactions

EXP
ISO

Atorvastatin results in increased expression of TP53 protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]

PMID:29630879 PMID:37121058

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

TNF receptor associated factor 6

multiple interactions

EXP

[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA

NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272

G

tubulin beta 3 class III

increases expression

ISO

Atorvastatin results in increased expression of TUBB3 protein

NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761

G

vascular cell adhesion molecule 1

decreases expression
multiple interactions

EXP
ISO

Atorvastatin results in decreased expression of VCAM1 mRNA; Atorvastatin results in decreased expression of VCAM1 protein
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of VCAM1 protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

PMID:17589825 PMID:17673219 PMID:22245985 PMID:25058445

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

G

vascular endothelial growth factor D

affects expression

EXP

Atorvastatin affects the expression of VEGFD mRNA

NCBI chr X:15,345,596...15,384,413
Ensembl chr X:15,345,596...15,384,413

G

vimentin

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VIM protein]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

von Willebrand factor

increases expression

EXP

Atorvastatin results in increased expression of VWF protein

NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770

G

Wnt family member 5A

increases expression
multiple interactions

ISO

Atorvastatin results in increased expression of WNT5A mRNA
Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of WNT5A mRNA]; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of WNT5A protein]

NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539

G

WT1 transcription factor

multiple interactions

ISO

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of WT1 protein]

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

G

xin actin binding repeat containing 1

multiple interactions

ISO

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA

NCBI chr 3:39,183,215...39,192,595
Ensembl chr 3:39,183,210...39,192,596

calcium carbonate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

decreases expression

EXP

Calcium Carbonate results in decreased expression of BGLAP protein

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

G

calpain 1

increases activity

EXP

Calcium Carbonate analog results in increased activity of CAPN1 protein

NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006

G

caspase 3

increases activity

EXP

Calcium Carbonate analog results in increased activity of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

DNA damage inducible transcript 3

increases expression

EXP

Calcium Carbonate analog results in increased expression of DDIT3

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

parathyroid hormone

affects expression
decreases expression

EXP

Calcium Carbonate affects the expression of PTH protein
Calcium Carbonate results in decreased expression of PTH protein

PMID:1752077 PMID:2027271 PMID:3826069 PMID:7891547 PMID:8481062 More...

NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181

G

parathyroid hormone like hormone

decreases expression

EXP

Calcium Carbonate results in decreased expression of PTHLH protein

NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733

G

secreted phosphoprotein 1

decreases expression

ISO

Calcium Carbonate results in decreased expression of SPP1 protein

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

calcium dichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 10

increases expression

ISO

Calcium Chloride results in increased expression of ADAM10 mRNA; Calcium Chloride results in increased expression of ADAM10 protein

NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791

G

ADAM metallopeptidase domain 17

increases expression

ISO

Calcium Chloride results in increased expression of ADAM17 mRNA; Calcium Chloride results in increased expression of ADAM17 protein

NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732

G

alkaline phosphatase, biomineralization associated

increases expression

EXP

Calcium Chloride results in increased expression of ALPL mRNA

NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410

G

apolipoprotein C3

increases expression

EXP

Calcium Chloride results in increased expression of APOC3 protein

NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072

G

ATP synthase peripheral stalk subunit F6

increases expression

EXP

Calcium Chloride results in increased expression of ATP5PF protein

NCBI chr21:25,724,500...25,735,653
Ensembl chr21:25,716,503...25,735,673

G

BAG cochaperone 4

increases expression

EXP

Calcium Chloride results in increased expression of BAG4 protein

NCBI chr 8:38,176,855...38,213,301
Ensembl chr 8:38,176,533...38,213,301

G

bone gamma-carboxyglutamate protein

increases expression

EXP

Calcium Chloride results in increased expression of BGLAP mRNA

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

G

BICD cargo adaptor 2

increases expression

EXP

Calcium Chloride results in increased expression of BICD2 protein

NCBI chr 9:92,711,363...92,764,833
Ensembl chr 9:92,711,363...92,764,833

G

calmodulin 3

multiple interactions

EXP

Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein]

NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782

G

caspase 3

multiple interactions
increases cleavage

ISO

cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

increases cleavage
multiple interactions

ISO

Calcium Chloride results in increased cleavage of CASP9 protein
cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

calcium sensing receptor

multiple interactions
increases activity

EXP

Calcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]
Calcium Chloride results in increased activity of CASR protein

PMID:16316325 PMID:17376781

NCBI chr 3:122,183,668...122,291,629
Ensembl chr 3:122,183,668...122,291,629

G

C-C motif chemokine ligand 2

increases phosphorylation
increases expression
multiple interactions

ISO

Calcium Chloride results in increased phosphorylation of CCL2 protein
Calcium Chloride results in increased expression of CCL2 mRNA; Calcium Chloride results in increased expression of CCL2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CCL2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased phosphorylation of CCL2 protein]

PMID:21530968 PMID:22728078

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

chaperonin containing TCP1 subunit 6A

decreases expression

EXP

Calcium Chloride results in decreased expression of CCT6A protein

NCBI chr 7:56,051,765...56,063,989
Ensembl chr 7:56,051,685...56,063,989

G

CD68 molecule

multiple interactions
increases expression

ISO

resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CD68 mRNA]

NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111

G

cyclin dependent kinase inhibitor 1B

multiple interactions

ISO

Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 2A

multiple interactions

ISO

Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A protein]

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

CCAAT enhancer binding protein alpha

increases activity

EXP

Calcium Chloride results in increased activity of CEBPA protein

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

C-type lectin domain family 3 member B

increases expression

EXP

Calcium Chloride results in increased expression of CLEC3B protein

NCBI chr 3:45,026,303...45,036,071
Ensembl chr 3:45,001,548...45,036,071

G

chloride intracellular channel 3

decreases expression

EXP

Calcium Chloride results in decreased expression of CLIC3 protein

NCBI chr 9:136,994,608...136,996,568
Ensembl chr 9:136,994,608...136,996,568

G

CKLF like MARVEL transmembrane domain containing 6

increases expression

EXP

Calcium Chloride results in increased expression of CMTM6 protein

NCBI chr 3:32,481,312...32,502,852
Ensembl chr 3:32,481,312...32,502,852

G

collagen type I alpha 1 chain

increases expression

EXP

Calcium Chloride results in increased expression of COL1A1 mRNA

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type VIII alpha 1 chain

increases expression

EXP

Calcium Chloride results in increased expression of COL8A1 protein

NCBI chr 3:99,638,594...99,799,217
Ensembl chr 3:99,638,475...99,799,226

G

COP9 signalosome subunit 3

increases expression

EXP

Calcium Chloride results in increased expression of COPS3 protein

NCBI chr17:17,246,616...17,281,246
Ensembl chr17:17,246,616...17,281,273

G

cystatin C

increases expression

EXP

Calcium Chloride results in increased expression of CST3 protein

NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473

G

collagen triple helix repeat containing 1

decreases expression

EXP

Calcium Chloride results in decreased expression of CTHRC1 protein

NCBI chr 8:103,371,538...103,382,989
Ensembl chr 8:103,371,538...103,382,989

G

cathepsin B

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of CTSB protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSB protein]

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin K

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of CTSK protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSK protein]

NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577

G

decorin

decreases expression

EXP

Calcium Chloride results in decreased expression of DCN protein

NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217

G

DExD-box helicase 39B

increases expression

EXP

Calcium Chloride results in increased expression of DDX39B protein

NCBI chr 6:31,530,226...31,542,003
Ensembl chr 6:31,530,219...31,542,448

G

EH domain containing 2

increases expression

EXP

Calcium Chloride results in increased expression of EHD2 protein

NCBI chr19:47,713,422...47,743,134
Ensembl chr19:47,713,422...47,743,134

G

coagulation factor X

multiple interactions

EXP

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529

G

coagulation factor XI

multiple interactions

EXP

[F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein

NCBI chr 4:186,266,189...186,289,681
Ensembl chr 4:186,266,189...186,289,681

G

coagulation factor II, thrombin

multiple interactions

EXP

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor V

multiple interactions

EXP

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr 1:169,511,951...169,586,481
Ensembl chr 1:169,511,951...169,586,588

G

coagulation factor IX

multiple interactions

EXP

[F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein

NCBI chr X:139,530,739...139,563,459
Ensembl chr X:139,530,739...139,563,459

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

EXP

Calcium Chloride results in increased expression of FYN protein

NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452

G

GIT ArfGAP 1

increases expression

EXP

Calcium Chloride results in increased expression of GIT1 protein

NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054

G

gonadotropin releasing hormone 1

multiple interactions

ISO

[manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein

NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654

G

G protein-coupled receptor 89B

increases expression

EXP

Calcium Chloride results in increased expression of GPR89B protein

NCBI chr 1:147,928,420...148,025,934
Ensembl chr 1:147,928,393...147,993,592
Ensembl chr 1:147,928,393...147,993,592

G

glutathione peroxidase 1

multiple interactions
increases expression

ISO

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]

PMID:21530968 PMID:24337353

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 3

multiple interactions
increases expression

ISO

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]

PMID:21530968 PMID:24337353

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

heme oxygenase 1

multiple interactions

EXP
ISO

Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

HtrA serine peptidase 1

decreases expression

EXP

Calcium Chloride results in decreased expression of HTRA1 protein

NCBI chr10:122,461,553...122,514,907
Ensembl chr10:122,458,551...122,514,907

G

intercellular adhesion molecule 1

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of ICAM1 mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of ICAM1 mRNA]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

intraflagellar transport 27

increases expression

EXP

Calcium Chloride results in increased expression of IFT27 protein

NCBI chr22:36,758,211...36,776,119
Ensembl chr22:36,758,202...36,776,256

G

interleukin 1 beta

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of IL1B protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of IL1B protein]

PMID:22728078 PMID:36731150

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

inter-alpha-trypsin inhibitor heavy chain 1

multiple interactions

EXP

Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]

NCBI chr 3:52,777,599...52,792,068
Ensembl chr 3:52,777,595...52,792,068

G

inter-alpha-trypsin inhibitor heavy chain 2

multiple interactions

EXP

Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr10:7,703,316...7,749,520
Ensembl chr10:7,703,316...7,749,520

G

kallikrein related peptidase 8

increases activity

EXP

Calcium Chloride results in increased activity of KLK8 protein

NCBI chr19:50,996,008...51,001,604
Ensembl chr19:50,996,007...51,002,711

G

LIM and SH3 protein 1

increases expression

EXP

Calcium Chloride results in increased expression of LASP1 protein

NCBI chr17:38,870,058...38,921,770
Ensembl chr17:38,869,859...38,921,770

G

LRR binding FLII interacting protein 1

decreases expression

EXP

Calcium Chloride results in decreased expression of LRRFIP1 protein

NCBI chr 2:237,627,587...237,781,643
Ensembl chr 2:237,627,587...237,813,682

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Calcium Chloride results in increased phosphorylation of MAPK1 protein
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein]

PMID:21215118 PMID:33621091

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases expression
multiple interactions
increases phosphorylation

EXP
ISO

Calcium Chloride results in increased expression of MAPK3 protein
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein]
Calcium Chloride results in increased phosphorylation of MAPK3 protein

PMID:21215118 PMID:25824407 PMID:33621091

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

matrix metallopeptidase 2

increases expression
increases activity
multiple interactions

ISO
EXP

Calcium Chloride results in increased expression of MMP2 mRNA; Calcium Chloride results in increased expression of MMP2 protein
Calcium Chloride results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]
Calcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]

PMID:10086886 PMID:16159824 PMID:20621845 PMID:21530968 PMID:22728078 More...

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

increases expression
increases activity
multiple interactions

ISO

Calcium Chloride results in increased expression of MMP9 mRNA; Calcium Chloride results in increased expression of MMP9 protein
Calcium Chloride results in increased activity of MMP9 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]

PMID:20621845 PMID:21530968 PMID:22728078 PMID:24337353

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC protein]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

neutrophil cytosolic factor 1

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of NCF1 mRNA; Calcium Chloride results in increased expression of NCF1 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 protein]

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

G

nitric oxide synthase 1

multiple interactions

ISO

Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene]

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

G

nitric oxide synthase 2

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of NOS2 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NOS2 mRNA]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

5', 3'-nucleotidase, cytosolic

increases expression

EXP

Calcium Chloride results in increased expression of NT5C protein

NCBI chr17:75,130,228...75,131,742
Ensembl chr17:75,130,225...75,131,757

G

nucleoredoxin

increases expression

EXP

Calcium Chloride results in increased expression of NXN protein

NCBI chr17:799,310...979,776
Ensembl chr17:799,310...979,776

G

paraoxonase 1

multiple interactions

EXP

Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon]

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

periostin

decreases expression

EXP

Calcium Chloride results in decreased expression of POSTN protein

NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844

G

POTE ankyrin domain family member K, pseudogene

increases expression

EXP

Calcium Chloride results in increased expression of POTEKP protein

NCBI chr 2:131,592,042...131,626,429
Ensembl chr 2:131,591,752...131,628,147

G

peptidylprolyl isomerase D

increases expression

EXP

Calcium Chloride results in increased expression of PPID mRNA; Calcium Chloride results in increased expression of PPID protein

NCBI chr 4:158,709,127...158,723,396
Ensembl chr 4:158,709,127...158,723,396

G

presenilin 2

increases expression

EXP

Calcium Chloride results in increased expression of PSEN2 protein

NCBI chr 1:226,870,616...226,903,668
Ensembl chr 1:226,870,184...226,927,726

G

RAD50 double strand break repair protein

decreases expression

EXP

Calcium Chloride results in decreased expression of RAD50 protein

NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349

G

reversion inducing cysteine rich protein with kazal motifs

increases expression

EXP

Calcium Chloride results in increased expression of RECK protein

NCBI chr 9:36,036,913...36,124,455
Ensembl chr 9:36,036,913...36,124,455

G

S100 calcium binding protein A13

multiple interactions

EXP

[Calcium Chloride co-treated with cuprous chloride] binds to and affects the folding of S100A13 protein; Calcium Chloride binds to and affects the folding of S100A13 protein

NCBI chr 1:153,618,799...153,634,361
Ensembl chr 1:153,618,779...153,634,412

G

S100 calcium binding protein A8

increases expression

EXP

Calcium Chloride results in increased expression of S100A8 mRNA; Calcium Chloride results in increased expression of S100A8 protein

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

S100 calcium binding protein A9

increases expression

EXP

Calcium Chloride results in increased expression of S100A9 mRNA; Calcium Chloride results in increased expression of S100A9 protein

NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023

G

SHC adaptor protein 1

increases expression

EXP

Calcium Chloride results in increased expression of SHC1 protein

NCBI chr 1:154,962,298...154,974,376
Ensembl chr 1:154,962,298...154,974,395

G

superoxide dismutase 2

increases activity
multiple interactions

ISO

Calcium Chloride results in increased activity of SOD2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of SOD2 protein]

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

signal transducer and activator of transcription 6

decreases expression

EXP

Calcium Chloride results in decreased expression of STAT6 protein

NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139

G

synapsin I

multiple interactions

ISO

[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]

NCBI chr X:47,571,901...47,619,857
Ensembl chr X:47,571,901...47,619,857

G

transforming growth factor beta 1

decreases expression

EXP

Calcium Chloride results in decreased expression of TGFB1 protein

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

TIMP metallopeptidase inhibitor 1

decreases expression
multiple interactions

ISO

Calcium Chloride results in decreased expression of TIMP1 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in decreased expression of TIMP1 mRNA]

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of TNF mRNA]
cordycepin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]
Calcium Chloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
Calcium Chloride results in increased expression of TNF mRNA; Calcium Chloride results in increased expression of TNF protein

PMID:21530968 PMID:22728078 PMID:36416909 PMID:36731150

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF alpha induced protein 6

multiple interactions

EXP

Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046

G

transient receptor potential cation channel subfamily V member 1

multiple interactions
increases activity

ISO

Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]
Ionomycin inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [Calcium Chloride results in increased activity of TRPV1 protein]

NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411

G

ubiquitin protein ligase E3B

multiple interactions

EXP

Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein]

NCBI chr12:109,477,634...109,547,829
Ensembl chr12:109,477,402...109,536,705

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases phosphorylation
multiple interactions

ISO

Calcium Chloride results in decreased phosphorylation of UQCRFS1 protein
[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; [tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]; Cyclosporine inhibits the reaction [[tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]

NCBI chr19:29,205,320...29,213,151
Ensembl chr19:29,205,320...29,213,151

G

vascular endothelial growth factor A

increases expression
multiple interactions

ISO

Calcium Chloride results in increased expression of VEGFA mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of VEGFA mRNA]

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

calcium oxalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

EXP

Calcium Oxalate results in increased expression of BAX protein
SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

EXP

Calcium Oxalate results in decreased expression of BCL2 protein
SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

multiple interactions
increases cleavage

EXP

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

multiple interactions
decreases expression

ISO

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

ISO

Calcium Oxalate results in decreased expression of CCL2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CCL2 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]

PMID:37414240 PMID:37454925

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

CD44 molecule (IN blood group)

multiple interactions
decreases expression

ISO

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CD44 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]

PMID:37414240 PMID:37454925

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

cytochrome b-245 beta chain

increases expression
multiple interactions

ISO

Calcium Oxalate results in increased expression of NOX2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX2 protein]

NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461

G

histone deacetylase 1

multiple interactions

ISO

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA]

NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635

G

histone deacetylase 2

multiple interactions

ISO

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA]

NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308

G

histone deacetylase 3

multiple interactions

ISO

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA]

NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849

G

histone deacetylase 8

multiple interactions

ISO

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA]

NCBI chr X:72,329,516...72,572,843
Ensembl chr X:72,329,516...72,573,101

G

heme oxygenase 1

multiple interactions
increases expression

EXP

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

inositol 1,4,5-trisphosphate receptor type 1

increases expression
multiple interactions

ISO

Calcium Oxalate results in increased expression of ITPR1 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein]

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

inositol 1,4,5-trisphosphate receptor type 2

increases expression
multiple interactions

ISO

Calcium Oxalate results in increased expression of ITPR2 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein]

NCBI chr12:26,335,352...26,833,194
Ensembl chr12:26,335,352...26,833,194

G

inositol 1,4,5-trisphosphate receptor type 3

increases expression

ISO

Calcium Oxalate results in increased expression of ITPR3 protein

NCBI chr 6:33,621,322...33,696,562
Ensembl chr 6:33,620,365...33,696,574

G

NADPH oxidase 4

increases expression
multiple interactions

ISO

Calcium Oxalate results in increased expression of NOX4 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX4 protein]

NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187

G

sirtuin 1

multiple interactions
decreases expression

EXP

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

superoxide dismutase 1

decreases expression
multiple interactions

ISO

Calcium Oxalate results in decreased expression of SOD1 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SOD1 protein]

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

secreted phosphoprotein 1

decreases expression
multiple interactions

ISO

Calcium Oxalate results in decreased expression of SPP1 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]

PMID:37414240 PMID:37454925

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

calcium phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 10

increases expression

EXP

calcium phosphate results in increased expression of CXCL10 protein

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 12

increases expression

EXP

calcium phosphate results in increased expression of CXCL12 protein

NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493

rosuvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression
multiple interactions

EXP

Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 11

multiple interactions

EXP
ISO

Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium

PMID:15901796 PMID:19853032

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression
affects secretion

EXP
ISO

ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium

PMID:19853032 PMID:23562342 PMID:24909372

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

increases expression

ISO

Rosuvastatin Calcium results in increased expression of ABCC3 protein

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily G member 1

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA

NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,304,389

G

ATP binding cassette subfamily G member 2 (JR blood group)

multiple interactions
increases activity

ISO
EXP

[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein

PMID:19853032 PMID:30083819

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

acetylcholinesterase (Yt blood group)

multiple interactions

ISO

[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

AKT serine/threonine kinase 1

affects phosphorylation

ISO

Rosuvastatin Calcium affects the phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

apolipoprotein A1

multiple interactions
increases expression

EXP

Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein]

PMID:12767421 PMID:15539964

NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622

G

apolipoprotein B

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of APOB protein

PMID:15539964 PMID:18702965

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

complement C3

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of C3 mRNA

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

caspase 3

increases activity
increases expression

EXP
ISO

Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein

PMID:21478229 PMID:32771489

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

increases activity
multiple interactions

ISO

Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]

PMID:20146376 PMID:32007421 PMID:35130744

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of CCL2 mRNA

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cAMP responsive element binding protein 5

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of CREB5 mRNA

NCBI chr 7:28,299,321...28,825,894
Ensembl chr 7:28,299,321...28,825,894

G

C-reactive protein

multiple interactions

EXP

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

ISO

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

ISO

Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

PMID:16633368 PMID:21562509

NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461

G

estrogen receptor 1

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

glutamate-cysteine ligase catalytic subunit

increases expression
multiple interactions

EXP

Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

G protein-coupled receptor 183

multiple interactions
increases expression

EXP

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA]

NCBI chr13:99,294,539...99,307,399
Ensembl chr13:99,294,539...99,307,399

G

granzyme K

multiple interactions
increases expression

EXP

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA]

NCBI chr 5:55,024,256...55,034,570
Ensembl chr 5:55,024,256...55,034,570

G

hepatocyte nuclear factor 4 alpha

increases secretion

ISO

HNF4A protein results in increased secretion of Rosuvastatin Calcium

NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845

G

interleukin 18 receptor accessory protein

decreases expression
multiple interactions

EXP

Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]

NCBI chr 2:102,418,621...102,452,565
Ensembl chr 2:102,418,689...102,452,565

G

interleukin 1 beta

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

potassium voltage-gated channel subfamily H member 2

decreases activity

EXP

Rosuvastatin Calcium results in decreased activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium inwardly rectifying channel subfamily J member 15

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA

NCBI chr21:38,229,926...38,307,357
Ensembl chr21:38,155,549...38,307,357

G

kinase insert domain receptor

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

myoglobin

affects expression

ISO

Rosuvastatin Calcium affects the expression of MB protein

NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951

G

myostatin

increases expression

ISO

Rosuvastatin Calcium results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]

PMID:32007421 PMID:35130744

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nitric oxide synthase 2

increases expression
multiple interactions

ISO

Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]

PMID:21443142 PMID:32007421 PMID:35130744

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions
increases expression
affects response to substance

EXP
ISO

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium

PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

orosomucoid 1

multiple interactions
decreases expression

EXP

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA]

NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]

NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776

G

peptidase inhibitor 3

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of PI3 mRNA

NCBI chr20:45,174,902...45,176,544
Ensembl chr20:45,174,902...45,176,544

G

selectin P

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of SELP mRNA

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

G

serpin family E member 2

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]

NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318

G

solute carrier organic anion transporter family member 1A2

increases uptake
multiple interactions
decreases expression

EXP
ISO

SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium
SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]

PMID:24909372 PMID:26888941 PMID:28867436

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

solute carrier organic anion transporter family member 1B1

multiple interactions
increases uptake

EXP

Fusidic Acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Rosuvastatin Calcium]; Rifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Rosuvastatin Calcium]; SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Rosuvastatin Calcium

PMID:23564645 PMID:26888941 PMID:31299240

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

G

solute carrier organic anion transporter family member 1B3

multiple interactions
increases uptake

EXP
ISO

Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]

PMID:26888941 PMID:31299240

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

solute carrier organic anion transporter family member 2B1

multiple interactions
increases uptake

EXP

Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549

G

superoxide dismutase 1

multiple interactions
increases expression

ISO

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

trefoil factor 1

decreases expression

ISO

Rosuvastatin Calcium results in decreased expression of TFF1 mRNA

NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535

G

transforming growth factor beta 1

multiple interactions
decreases expression

ISO

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA

PMID:15681303 PMID:27097221

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

decreases expression
multiple interactions

ISO

Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]

PMID:15681303 PMID:32007421 PMID:35130744

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

troponin I3, cardiac type

multiple interactions

ISO

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]

PMID:32007421 PMID:35130744

NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773

G

vanin 3, pseudogene

decreases expression

EXP

Rosuvastatin Calcium results in decreased expression of VNN3P mRNA

NCBI chr 6:132,722,787...132,734,765
Ensembl chr 6:132,722,784...132,736,935
Ensembl chr 6:132,722,784...132,736,935

G

WT1 transcription factor

increases expression

ISO

Rosuvastatin Calcium results in increased expression of WT1 mRNA

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

tricalcium bis(phosphate)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dynamin 1 like

increases expression

ISO

tricalcium phosphate results in increased expression of DNM1L protein

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

heme oxygenase 1

decreases expression

ISO

tricalcium phosphate results in decreased expression of HMOX1 protein

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

microtubule associated protein 1 light chain 3 beta

multiple interactions
affects localization

ISO

Acetylcysteine inhibits the reaction [tricalcium phosphate affects the localization of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [tricalcium phosphate results in increased expression of MAP1LC3B protein]

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mitofusin 2

decreases expression

ISO

tricalcium phosphate results in decreased expression of MFN2 protein

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

mixed lineage kinase domain like pseudokinase

increases phosphorylation
multiple interactions

ISO

tricalcium phosphate results in increased phosphorylation of MLKL protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]

NCBI chr16:74,671,855...74,700,862
Ensembl chr16:74,671,855...74,700,960

G

NFE2 like bZIP transcription factor 2

decreases expression

ISO

tricalcium phosphate results in decreased expression of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NAD(P)H quinone dehydrogenase 1

decreases expression

ISO

tricalcium phosphate results in decreased expression of NQO1 protein

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

PTEN induced kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased expression of PINK1 protein]; tricalcium phosphate results in increased expression of and results in increased localization of PINK1 protein

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

receptor interacting serine/threonine kinase 1

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]

NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187

G

receptor interacting serine/threonine kinase 3

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]

NCBI chr14:24,336,025...24,339,991
Ensembl chr14:24,336,025...24,340,022

G

sequestosome 1

decreases expression
multiple interactions

ISO

tricalcium phosphate results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in decreased expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

thioredoxin

decreases expression

ISO

tricalcium phosphate results in decreased expression of TXN1 protein

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

G

thioredoxin interacting protein

increases expression

ISO

tricalcium phosphate results in increased expression of TXNIP protein

NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26798
chemical entity	26778
molecular entity	26760
ion	20029
monoatomic ion	19090
monoatomic cation	18461
metal cation	18461
calcium ion	374
calcium cation +	373
Path 2
Term	Annotations
CHEBI ontology	26798
subatomic particle	26774
composite particle	26774
hadron	26774
baryon	26774
nucleon	26774
atomic nucleus	26774
atom	26774
main group element atom	26525
main group molecular entity	26525
s-block molecular entity	25560
alkaline earth molecular entity	932
calcium molecular entity	773
elemental calcium	771
calcium ion	374
calcium cation +	373

paths to the root