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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-hexachlorocyclohexane
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Accession:CHEBI:39096 term browser browse the term
Definition:A hexachlorocyclohexane that has formula C6H6Cl6.
Synonyms:exact_synonym: (1R,2R,3R,4R,5S,6S)-1,2,3,4,5,6-hexachlorocyclohexane
 related_synonym: (1alpha,2alpha,3beta,4beta,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane;   (1r,2c,3t,4t,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane;   1alpha,2alpha,3beta,4alpha,5beta,6beta-Hexachlorocyclohexane;   Formula=C6H6Cl6;   InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m1/s1;   InChIKey=JLYXXMFPNIAWKQ-SHFUYGGZSA-N;   SMILES=Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@H]1Cl;   alpha-BHC;   alpha-HCH;   alpha-Lindane;   alpha-benzene hexachloride;   alpha-hexachlorane
 xref: Beilstein:1907336;   CAS:319-84-6;   Gmelin:794031;   KEGG:C15214
 xref_mesh: MESH:C040534


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alpha-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCB4 mRNA CTD PMID:16940010 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:17785943 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases methylation ISO alpha-hexachlorocyclohexane results in increased methylation of ABL1 promoter CTD PMID:35788154 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA CTD PMID:16940010 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA CTD PMID:17785943 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ADAP2 mRNA CTD PMID:16940010 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ADH1 mRNA CTD PMID:16940010 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA CTD PMID:17785943 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Apoc1 apolipoprotein C1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA CTD PMID:16940010 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G App amyloid beta precursor protein increases expression EXP alpha-hexachlorocyclohexane results in increased expression of APP mRNA CTD PMID:17785943 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:10696776 PMID:15084347 PMID:21962538 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA CTD PMID:17785943 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp3 caspase 3 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of CASP3 protein CTD PMID:19818741 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
alpha-hexachlorocyclohexane results in increased activity of CAT protein		 CTD PMID:1708174 PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbx1 chromobox 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA CTD PMID:16940010 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096 		JBrowse link
G Cd36 CD36 molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CD36 mRNA CTD PMID:17785943 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdc123 cell division cycle 123 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CDC123 mRNA CTD PMID:16940010 NCBI chr17:72,459,270...72,503,316
Ensembl chr17:72,459,282...72,503,316 		JBrowse link
G Cdk17 cyclin-dependent kinase 17 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CDK17 mRNA CTD PMID:16940010 NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CES2 mRNA CTD PMID:17785943 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 decreases expression
increases expression
affects expression		 EXP alpha-hexachlorocyclohexane results in decreased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in increased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane affects the expression of CHCHD2 mRNA		 CTD PMID:16940010 NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755 		JBrowse link
G Cpn1 carboxypeptidase N subunit 1 affects expression
decreases expression
increases expression		 EXP alpha-hexachlorocyclohexane affects the expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in increased expression of CPN1 mRNA		 CTD PMID:16940010 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465 		JBrowse link
G Ctsc cathepsin C decreases expression
affects expression
increases expression		 EXP alpha-hexachlorocyclohexane results in decreased expression of CTSC mRNA
alpha-hexachlorocyclohexane affects the expression of CTSC mRNA
alpha-hexachlorocyclohexane results in increased expression of CTSC mRNA		 CTD PMID:16940010 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cyb5a cytochrome b5 type A affects expression EXP alpha-hexachlorocyclohexane affects the expression of CYB5A mRNA CTD PMID:17785943 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA CTD PMID:17785943 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein CTD PMID:11165752 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein CTD PMID:16246485 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases activity		 EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2B1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 protein
alpha-hexachlorocyclohexane results in increased activity of CYP2B1 protein		 CTD PMID:1372805 PMID:11165752 PMID:16246485 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B15 mRNA CTD PMID:17785943 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein CTD PMID:16246485 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA CTD PMID:17785943 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression
multiple interactions		 EXP alpha-hexachlorocyclohexane results in increased expression of CYP2C6 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6 protein		 CTD PMID:16246485 PMID:16940010 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein CTD PMID:16246485 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein		 CTD PMID:11165752 PMID:16246485 PMID:16940010 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16940010 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNA CTD PMID:17785943 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP51 mRNA CTD PMID:17785943 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression
affects expression
increases expression		 EXP alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNA
alpha-hexachlorocyclohexane affects the expression of ECI1 mRNA
alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNA		 CTD PMID:16940010 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA CTD PMID:17785943 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
increases activity		 EXP alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA
alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein		 CTD PMID:1372805 PMID:16940010 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity		 EXP
ISO		 alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
alpha-hexachlorocyclohexane results in increased activity of ESR1 protein		 CTD PMID:10580743 PMID:26022396 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fev FEV transcription factor, ETS family member decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of FEV mRNA CTD PMID:17785943 NCBI chr 9:76,439,164...76,443,603
Ensembl chr 9:76,439,172...76,443,065 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases response to substance EXP alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein CTD PMID:1715812 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FKBP3 mRNA CTD PMID:17785943 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA CTD PMID:17785943 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] CTD PMID:1380685 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FTL1 mRNA CTD PMID:16940010 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
multiple interactions		 EXP
ISO		 alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]		 CTD PMID:9316872 PMID:17785943 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression
increases expression
decreases expression		 EXP alpha-hexachlorocyclohexane affects the expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in increased expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in decreased expression of GAPDH mRNA		 CTD PMID:16940010 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA CTD PMID:17785943 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions		 EXP alpha-hexachlorocyclohexane results in increased expression of GSR mRNA
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein		 CTD PMID:16046044 PMID:17785943 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA5 mRNA CTD PMID:17785943 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTK1 mRNA CTD PMID:16940010 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression
affects expression
increases expression		 EXP alpha-hexachlorocyclohexane results in decreased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane affects the expression of GSTM4 mRNA
alpha-hexachlorocyclohexane results in increased expression of GSTM4 mRNA		 CTD PMID:16940010 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of GSTP1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of GSTP1 protein
alpha-hexachlorocyclohexane results in increased expression of GSTP1 mRNA		 CTD PMID:16246485 PMID:16940010 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP alpha-hexachlorocyclohexane results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA CTD PMID:17785943 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 affects expression EXP alpha-hexachlorocyclohexane affects the expression of KCNJ5 mRNA CTD PMID:17785943 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of KIT mRNA CTD PMID:16940010 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of LPL mRNA CTD PMID:17785943 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrp2 LDL receptor related protein 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of LRP2 mRNA CTD PMID:16940010 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Luc7l2 LUC7-like 2 pre-mRNA splicing factor affects expression EXP alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNA CTD PMID:17785943 NCBI chr 4:67,287,593...67,347,986
Ensembl chr 4:67,287,640...67,347,964 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
decreases expression
affects expression		 EXP alpha-hexachlorocyclohexane results in increased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane affects the expression of MAPK1 mRNA		 CTD PMID:16940010 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MAPK6 mRNA CTD PMID:16940010 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ME1 mRNA CTD PMID:17785943 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Meox2 mesenchyme homeobox 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA CTD PMID:17785943 NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression EXP alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA CTD PMID:16940010 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Muc13 mucin 13, cell surface associated decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of MUC13 mRNA CTD PMID:17785943 NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA] CTD PMID:28273962 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncl nucleolin increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NCL mRNA CTD PMID:17785943 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions		 ISO alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA
Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]		 CTD PMID:28273962 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NQO1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO alpha-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
alpha-hexachlorocyclohexane results in increased activity of NR1I2 protein		 CTD PMID:21115097 PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of OGG1 mRNA CTD PMID:16246485 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Onecut1 one cut homeobox 1 affects expression EXP alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNA CTD PMID:17785943 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of PCNA protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of PCNA protein CTD PMID:16246485 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA CTD PMID:17785943 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025 		JBrowse link
G Prss8 serine protease 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA CTD PMID:17785943 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNA CTD PMID:17785943 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNA CTD PMID:16940010 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358 		JBrowse link
G Psme1 proteasome activator subunit 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNA CTD PMID:16940010 NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RAB7 mRNA CTD PMID:17785943 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression
decreases expression
increases expression		 EXP alpha-hexachlorocyclohexane affects the expression of RB1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA
alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA		 CTD PMID:16940010 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rnpep arginyl aminopeptidase decreases expression
affects expression
increases expression		 EXP alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA
alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA
alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA		 CTD PMID:16940010 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RPLP0 mRNA CTD PMID:16940010 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SCD1 mRNA CTD PMID:17785943 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 affects expression
decreases expression
increases expression		 EXP alpha-hexachlorocyclohexane affects the expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in increased expression of SLC16A1 mRNA		 CTD PMID:16940010 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SLC17A1 mRNA CTD PMID:17785943 NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304 		JBrowse link
G Smpx small muscle protein, X-linked decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SMPX mRNA CTD PMID:17785943 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708 		JBrowse link
G Snx4 sorting nexin 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SNX4 mRNA CTD PMID:17785943 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein] CTD PMID:10993823 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA CTD PMID:16940010 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA CTD PMID:16940010 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
affects expression		 EXP alpha-hexachlorocyclohexane results in increased expression of TP53 mRNA
alpha-hexachlorocyclohexane results in decreased expression of TP53 mRNA
alpha-hexachlorocyclohexane affects the expression of TRP53 mRNA		 CTD PMID:16940010 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ubc ubiquitin C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UBC mRNA CTD PMID:16940010 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A5 mRNA CTD PMID:17785943 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA CTD PMID:17785943 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA CTD PMID:16940010 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNA CTD PMID:16940010 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B mRNA CTD PMID:16940010 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      chemical role 19498
        environmental contaminant 18883
          persistent organic pollutant 16792
            alpha-hexachlorocyclohexane 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            organic hydride 18704
                              organic fundamental parent 18704
                                hydrocarbon 18452
                                  cyclic hydrocarbon 17239
                                    monocyclic hydrocarbon 6165
                                      cycloalkane 520
                                        cyclohexane 515
                                          chlorocyclohexane 513
                                            hexachlorocyclohexane 513
                                              alpha-hexachlorocyclohexane 110
paths to the root