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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ryanodine receptor modulator
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Accession:CHEBI:38809 term browser browse the term
Synonyms:related_synonym: RyR modulator;   ryanodine receptor modulators;   ryanodine-sensitive calcium channel modulator;   ryanodine-sensitive calcium-release channel modulator


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caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATM protein] CTD PMID:38104654 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552 		JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CCNB1 protein] CTD PMID:38104654 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDC25C protein] CTD PMID:38104654 NCBI chr 2:140,289,156...140,323,696
Ensembl chr 2:140,289,115...140,324,425 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDK1 protein] CTD PMID:38104654 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197 		JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of CHEK2 protein] CTD PMID:38104654 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G RYR1 ryanodine receptor 1 increases activity
multiple interactions		 EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
dantrolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 decreases activity
multiple interactions		 EXP Dantrolene results in decreased activity of RYR1 protein
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]; [Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977 		JBrowse link
ryanodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 affects binding
multiple interactions		 EXP Ryanodine binds to RYR1 protein; Ryanodine binds to RYR1 protein mutant form
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Ryanodine binds to RYR1 protein]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
G RYR2 ryanodine receptor 2 affects binding EXP Ryanodine binds to RYR2 protein CTD PMID:11278295 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 5151
    role 5118
      biological role 5118
        biophysical role 207
          membrane transport modulator 123
            calcium channel modulator 95
              ryanodine receptor modulator 8
                azumolene 0
                flubendiamide 0
                ruthenium red 1
                ryanodine 2
                ryanodine receptor agonist + 6
                ryanodine receptor antagonist + 1
                ryanoid insecticide 0
                tetrachlorantraniliprole 0
paths to the root