CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: organofluorine acaricide
Accession: CHEBI:38806
browse the term
Synonyms: related_synonym: fluoroorganic acaricide; fluororganische Akarizide; organofluorine acaricides
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation multiple interactions
ISO
etoxazole results in increased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [etoxazole results in increased phosphorylation of AKT1 protein]
CTD
PMID:33618463
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ar
androgen receptor
increases expression
ISO
etoxazole results in increased expression of AR mRNA
CTD
PMID:33618463
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects expression increases expression
ISO
etoxazole affects the expression of CYP17A1 mRNA etoxazole results in increased expression of CYP17A1 mRNA
CTD
PMID:33618463
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
etoxazole results in increased expression of CYP3A4 mRNA
CTD
PMID:17293382
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
etoxazole results in increased expression of JUN mRNA
CTD
PMID:33618463
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
etoxazole results in decreased expression of JUND mRNA
CTD
PMID:33618463
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]
CTD
PMID:33618463
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33618463
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Star
steroidogenic acute regulatory protein
increases expression affects expression
ISO
etoxazole results in increased expression of STAR mRNA etoxazole affects the expression of STAR mRNA
CTD
PMID:33618463
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [flucythrinate results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects binding
ISO
flucythrinate binds to CYP3A4 protein
CTD
PMID:32278787
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Esr1
estrogen receptor 1
increases activity
ISO
flucythrinate results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Mmp9
matrix metallopeptidase 9
affects binding
ISO
flucythrinate binds to MMP9 protein
CTD
PMID:32278787
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
flucythrinate binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Rora
RAR-related orphan receptor A
affects binding
ISO
flucythrinate binds to RORA protein
CTD
PMID:32278787
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Vdr
vitamin D receptor
affects binding
ISO
flucythrinate binds to VDR protein
CTD
PMID:32278787
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
flumethrin results in increased expression of BAX mRNA
CTD
PMID:34142587
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
flumethrin results in decreased expression of BCL2 mRNA
CTD
PMID:34142587
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
flumethrin results in increased expression of CDKN1A mRNA
CTD
PMID:34142587
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Esr1
estrogen receptor 1
increases expression
ISO
flumethrin results in increased expression of ESR1 mRNA
CTD
PMID:34142587
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases expression
ISO
flumethrin results in increased expression of ESR2 mRNA
CTD
PMID:34142587
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Pgr
progesterone receptor
increases expression
ISO
flumethrin results in increased expression of PGR mRNA
CTD
PMID:34142587
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Tff1
trefoil factor 1
increases expression
ISO
flumethrin results in increased expression of TFF1 mRNA
CTD
PMID:34142587
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tp53
tumor protein p53
increases expression
ISO
flumethrin results in increased expression of TP53 mRNA
CTD
PMID:34142587
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
fluvalinate analog promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:25684042
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Cdk2
cyclin dependent kinase 2
affects binding
ISO
fluvalinate binds to CDK2 protein
CTD
PMID:32278787
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects binding
ISO
fluvalinate binds to CYP3A4 protein
CTD
PMID:32278787
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Erbb2
erb-b2 receptor tyrosine kinase 2
affects binding
ISO
fluvalinate binds to ERBB2 protein
CTD
PMID:32278787
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Fgfr2
fibroblast growth factor receptor 2
affects binding
ISO
fluvalinate binds to FGFR2 protein
CTD
PMID:32278787
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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Mmp9
matrix metallopeptidase 9
affects binding
ISO
fluvalinate binds to MMP9 protein
CTD
PMID:32278787
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nqo1
NAD(P)H quinone dehydrogenase 1
affects binding
ISO
fluvalinate binds to NQO1 protein
CTD
PMID:32278787
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
fluvalinate binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Ppard
peroxisome proliferator-activated receptor delta
affects binding
ISO
fluvalinate binds to PPARD protein
CTD
PMID:32278787
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Rora
RAR-related orphan receptor A
affects binding
ISO
fluvalinate binds to RORA protein
CTD
PMID:32278787
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Rorc
RAR-related orphan receptor C
affects binding
ISO
fluvalinate binds to RORC protein
CTD
PMID:32278787
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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