Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imidazoquinoline
go back to main search page
Accession:CHEBI:38776 term browser browse the term
Synonyms:related_synonym: imidazoquinolines


show annotations for term's descendants           Sort by:
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport ISO ABCC2 protein affects the transport of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:16611851 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases mutagenesis ISO
EXP		 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of APC gene CTD PMID:7846077 PMID:8608549 PMID:12034317 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Aprt adenine phosphoribosyl transferase multiple interactions ISO [NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene
[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT gene		 CTD PMID:2023932 PMID:9150757 NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of ASF1A mRNA CTD PMID:26198647 NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased cleavage of CASP3 protein
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CASP3 mRNA		 CTD PMID:35985368 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CASP9 mRNA CTD PMID:35985368 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of CDH1 protein CTD PMID:22094457 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of CDKN1A protein
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CDKN1A mRNA		 CTD PMID:22094457 PMID:31542801 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis
multiple interactions		 EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene
[chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]		 CTD PMID:9515794 PMID:12628520 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects activity
increases expression		 ISO CYP1A1 affects the activity of 2-amino-3-methylimidazo(4,5-f)quinoline
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CYP1A1 mRNA		 CTD PMID:2334931 PMID:27644595 PMID:31542801 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
multiple interactions
increases activity
affects response to substance		 ISO
EXP		 CYP1A2 protein affects the metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CYP1A2 mRNA
Quercetin inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline]
[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT gene
CYP1A2 protein affects the susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
CYP1A2 protein results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline
[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline		 CTD PMID:2023932 PMID:2334931 PMID:2655891 PMID:9581821 PMID:10503888 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of FBXO30 mRNA CTD PMID:26198647 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein] CTD PMID:12628520 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation		 ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of H2AX protein modified form
2-amino-3-methylimidazo(4,5-f)quinoline results in increased phosphorylation of H2AX protein		 CTD PMID:28160022 PMID:34510228 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of HRAS gene CTD PMID:2009133 PMID:8844820 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of JUN protein CTD PMID:22094457 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of KRAS gene CTD PMID:8844820 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance
multiple interactions		 ISO NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline; [NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline		 CTD PMID:7625840 PMID:9150757 PMID:28160022 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:9581821 PMID:10503888 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:9581821 PMID:10503888 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:11159734 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of SULT1B1 mRNA CTD PMID:31542801 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR1 protein CTD PMID:22094457 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR2 protein CTD PMID:22094457 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of UGT1A1 mRNA CTD PMID:31542801 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Wnt1 Wnt family member 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of WNT1 protein CTD PMID:22094457 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
dactolisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO
EXP		 dactolisib results in decreased expression of AKT1 protein modified form
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib increases phosphorylation of Akt in rat tumor grafts		 CTD
RGD		 PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 More... RGD:152177690 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein] CTD PMID:23151917 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO dactolisib affects the expression of BCL2L1 protein CTD PMID:25640480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression ISO dactolisib affects the expression of BCL2L11 protein CTD PMID:25640480 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO dactolisib results in decreased expression of BIRC5 protein CTD PMID:22729845 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO dactolisib results in increased activity of CASP3 protein
dactolisib results in increased cleavage of CASP3 protein
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]		 CTD PMID:21372221 PMID:23151917 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of CCND1 protein CTD PMID:23651616 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dactolisib results in increased expression of CDKN1A protein CTD PMID:23651616 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions		 ISO dactolisib affects the localization of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein		 CTD PMID:23151917 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:24758408 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
increases response to substance
multiple interactions		 ISO dactolisib results in decreased phosphorylation of EIF4EBP1 protein
EIF4EBP1 protein modified form results in increased susceptibility to dactolisib
Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO dactolisib results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein] CTD PMID:22949526 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases metabolic processing
affects localization		 ISO dactolisib results in increased metabolism of MAP1LC3A protein
dactolisib affects the localization of MAP1LC3A protein		 CTD PMID:23651616 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:22415236 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22415236 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression
multiple interactions		 ISO dactolisib affects the expression of MCL1 protein
[dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein		 CTD PMID:25640480 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases response to substance ISO OGT mutant form results in increased susceptibility to dactolisib CTD PMID:23029544 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]
dactolisib results in decreased phosphorylation of OXSR1 protein		 CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dactolisib results in increased cleavage of PARP1 protein CTD PMID:21464613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases response to substance
decreases response to substance		 ISO PIK3CA results in increased susceptibility to dactolisib
PIK3CA results in decreased susceptibility to dactolisib		 CTD PMID:21372221 PMID:21633166 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO dactolisib results in decreased expression of RB1 protein modified form CTD PMID:23651616 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein] CTD PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 More... NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]
dactolisib results in decreased phosphorylation of SLC12A3 protein		 CTD PMID:22949526 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein] CTD PMID:23151917 PMID:23651616 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]
dactolisib results in decreased phosphorylation of STK39 protein		 CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
imiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] CTD PMID:24990399 PMID:29402411 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO imiquimod results in decreased expression of APEX1 mRNA CTD PMID:21878529 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO imiquimod results in decreased expression of BCL2 protein CTD PMID:20033192 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO imiquimod results in decreased expression of BLM mRNA CTD PMID:21878529 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO imiquimod results in decreased expression of BRCA2 mRNA CTD PMID:21878529 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Imiquimod results in increased expression of BST2 protein CTD PMID:31093508 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 ISO Imiquimod results in increased activity of CASP1 protein
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein]
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]		 CTD PMID:31383729 PMID:36577999 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO imiquimod results in increased activity of CASP3 protein
imiquimod results in increased cleavage of CASP3 protein		 CTD PMID:12902443 PMID:20033192 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Imiquimod results in increased secretion of CCL2 protein CTD PMID:34740670 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Imiquimod results in increased expression of CD274 protein CTD PMID:31093508 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions		 ISO Imiquimod results in increased expression of CD40 protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]		 CTD PMID:22916010 PMID:31093508 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Imiquimod results in increased expression of CD80 protein CTD PMID:31093508 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO imiquimod results in decreased expression of CHAF1A mRNA CTD PMID:21878529 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO imiquimod results in decreased expression of CHAF1B mRNA CTD PMID:21878529 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Ctsb cathepsin B increases activity ISO Imiquimod results in increased activity of CTSB protein CTD PMID:22916010 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsk cathepsin K increases activity ISO Imiquimod results in increased activity of CTSK protein CTD PMID:22916010 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L increases activity ISO Imiquimod results in increased activity of CTSL protein CTD PMID:22916010 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S increases activity ISO Imiquimod results in increased activity of CTSS protein CTD PMID:22916010 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] CTD PMID:28655636 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion
multiple interactions
increases expression		 ISO Imiquimod results in increased secretion of CXCL1 protein
hispidulin inhibits the reaction [Imiquimod results in increased expression of CXCL1 mRNA]		 CTD PMID:22916010 PMID:32679548 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
affects metabolic processing
increases chemical synthesis		 ISO CYP1A1 protein results in increased metabolism of Imiquimod
CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]
CYP1A1 protein affects the metabolism of Imiquimod
[CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite		 CTD PMID:31111189 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases chemical synthesis
increases metabolic processing		 ISO [CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the metabolism of Imiquimod
CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]		 CTD PMID:31111189 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO imiquimod results in decreased expression of ERCC2 mRNA CTD PMID:21878529 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO imiquimod results in increased expression of ERCC5 mRNA CTD PMID:21878529 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Fancl FA complementation group L decreases expression ISO imiquimod results in decreased expression of FANCL mRNA CTD PMID:21878529 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fbh1 F-box DNA helicase 1 decreases expression ISO imiquimod results in decreased expression of FBH1 mRNA CTD PMID:21878529 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO imiquimod results in decreased expression of FGF2 CTD PMID:16368197 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein] CTD PMID:36577999 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 decreases expression ISO imiquimod results in decreased expression of GTF2H3 mRNA CTD PMID:21878529 NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 decreases expression ISO imiquimod results in decreased expression of GTF2H4 mRNA CTD PMID:21878529 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984 		JBrowse link
G Gzmb granzyme B multiple interactions ISO Imiquimod results in increased expression of and results in increased secretion of GZMB protein CTD PMID:31093508 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G H2ax H2A.X variant histone decreases expression ISO Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] CTD PMID:21097750 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il11 interleukin 11 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] CTD PMID:31054998 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] CTD PMID:31054998 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases secretion		 ISO [imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]
Imiquimod results in increased secretion of IL12A protein		 CTD PMID:21097750 PMID:31093508 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases secretion
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:21097750 PMID:22916010 PMID:31054998 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] CTD PMID:31054998 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Imiquimod results in increased expression of IL13RA2 mRNA CTD PMID:31054998 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
increases secretion		 ISO (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]]
Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein
imiquimod results in increased secretion of IL17A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 PMID:32679548 PMID:36002070 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17b interleukin 17B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17B mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA]		 CTD PMID:31054998 NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565 		JBrowse link
G Il17rb interleukin 17 receptor B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA]		 CTD PMID:31054998 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL18 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA]		 CTD PMID:31054998 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18bp interleukin 18 binding protein increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL18BP mRNA
hispidulin inhibits the reaction [Imiquimod results in increased expression of IL18BP mRNA]		 CTD PMID:32679548 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] CTD PMID:31054998 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il19 interleukin 19 increases expression
multiple interactions		 ISO imiquimod results in increased expression of IL19 mRNA
resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA]		 CTD PMID:25965695 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] CTD PMID:31054998 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression		 ISO Imiquimod results in increased secretion of IL1B protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]
Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein; Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein]		 CTD PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 PMID:32679548 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1f10 interleukin 1 family member 10 decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL1F10 mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA]		 CTD PMID:31054998 NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Imiquimod results in increased expression of IL1RAP mRNA CTD PMID:31054998 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Il2 interleukin 2 increases secretion ISO Imiquimod results in increased secretion of IL2 protein CTD PMID:34740670 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il20 interleukin 20 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA]		 CTD PMID:31054998 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA]		 CTD PMID:31054998 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL22RA1 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]		 CTD PMID:31054998 NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296 		JBrowse link
G Il23a interleukin 23 subunit alpha increases secretion
multiple interactions
increases expression		 ISO imiquimod results in increased secretion of IL23A protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein]
Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il27 interleukin 27 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] CTD PMID:31054998 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] CTD PMID:31054998 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il36a interleukin 36, alpha increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36A mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA]		 CTD PMID:31054998 NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400 		JBrowse link
G Il36b interleukin 36, beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36B mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA]		 CTD PMID:31054998 NCBI chr 3:7,024,881...7,030,388
Ensembl chr 3:7,021,973...7,031,619 		JBrowse link
G Il36g interleukin 36, gamma multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] CTD PMID:31054998 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480 		JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] CTD PMID:31054998 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Il4 interleukin 4 increases secretion ISO Imiquimod results in increased secretion of IL4 protein CTD PMID:34740670 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of IL6 mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of IL6 protein]		 CTD PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7 interleukin 7 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL7 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA]		 CTD PMID:31054998 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Il7r interleukin 7 receptor multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] CTD PMID:31054998 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Il9r interleukin 9 receptor decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL9R mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA]		 CTD PMID:31054998 NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] CTD PMID:31054998 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IRAK3 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA]		 CTD PMID:31054998 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] CTD PMID:21097750 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO imiquimod results in decreased expression of KIF22 mRNA CTD PMID:21878529 NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401 		JBrowse link
G Lgmn legumain increases activity
multiple interactions		 ISO Imiquimod results in increased activity of LGMN protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]		 CTD PMID:22916010 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO imiquimod results in decreased expression of LIG1 mRNA CTD PMID:21878529 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 multiple interactions ISO LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] CTD PMID:30523158 NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK1 protein CTD PMID:20033192 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK3 protein CTD PMID:20033192 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO imiquimod results in decreased expression of MLH1 mRNA CTD PMID:21878529 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO imiquimod results in decreased activity of MMP9 protein CTD PMID:14708627 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression ISO imiquimod results in decreased expression of MPG mRNA CTD PMID:21878529 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mpo myeloperoxidase increases activity
increases expression
multiple interactions		 ISO imiquimod results in increased activity of MPO protein
Imiquimod results in increased expression of MPO protein
(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased activity of MPO protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased activity of MPO protein]]		 CTD PMID:26149470 PMID:32679548 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO imiquimod results in decreased expression of MRE11A mRNA CTD PMID:21878529 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO imiquimod results in decreased expression of MSH2 mRNA CTD PMID:21878529 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nudt1 nudix hydrolase 1 decreases expression ISO imiquimod results in decreased expression of NUDT1 mRNA CTD PMID:21878529 NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA CTD PMID:25965695 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions		 ISO Imiquimod results in increased expression of PCNA protein
Chloroquine inhibits the reaction [Imiquimod results in increased expression of PCNA protein]		 CTD PMID:36002070 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression ISO imiquimod results in decreased expression of PMS2 mRNA CTD PMID:21878529 NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO imiquimod results in decreased expression of POLE mRNA CTD PMID:21878529 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
G Poll DNA polymerase lambda decreases expression ISO imiquimod results in decreased expression of POLL mRNA CTD PMID:21878529 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO [resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA CTD PMID:25965695 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO imiquimod results in decreased expression of RAD51AP1 mRNA CTD PMID:21878529 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rad51d RAD51 paralog D decreases expression ISO imiquimod results in decreased expression of RAD51D mRNA CTD PMID:21878529 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rad54l RAD54 like decreases expression ISO imiquimod results in decreased expression of RAD54L mRNA CTD PMID:21878529 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions		 ISO imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]		 CTD PMID:26149470 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO imiquimod results in decreased expression of RUVBL2 mRNA CTD PMID:21878529 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Ssrp1 structure specific recognition protein 1 decreases expression ISO imiquimod results in decreased expression of SSRP1 mRNA CTD PMID:21878529 NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO imiquimod results in increased expression of STAT3 mRNA CTD PMID:26149470 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion ISO Imiquimod results in increased secretion of TGFB1 protein CTD PMID:34740670 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO imiquimod results in increased expression of TIMP1 protein CTD PMID:14708627 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr7 toll-like receptor 7 multiple interactions
increases cleavage
affects binding		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]
Imiquimod binds to TLR7 protein		 CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein]
Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein]
Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein		 CTD PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression ISO imiquimod results in increased expression of TREX1 mRNA CTD PMID:21878529 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA CTD PMID:25965695 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO imiquimod results in decreased expression of UHRF1 mRNA CTD PMID:21878529 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Wrnip1 WRN helicase interacting protein 1 decreases expression ISO imiquimod results in decreased expression of WRNIP1 mRNA CTD PMID:21878529 NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO imiquimod results in increased expression of XPC mRNA CTD PMID:21878529 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
resiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions
increases degradation		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resiquimod results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO resiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein]; 7-oxozeanol inhibits the reaction [resiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein]		 CTD PMID:28924041 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]; resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]; resiquimod promotes the reaction [RELA protein binds to CXCL10 promoter] CTD PMID:28924041 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions
increases secretion
increases expression		 ISO [resiquimod co-treated with Lipopolysaccharides] results in increased expression of IFNB1 mRNA; apilimod inhibits the reaction [resiquimod results in increased expression of IFNB1 mRNA]; apilimod inhibits the reaction [resiquimod results in increased secretion of IFNB1 protein] CTD PMID:15851485 PMID:24600036 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12B mRNA; [beta-Glucans co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; IFNG protein affects the reaction [[Zymosan co-treated with resiquimod] results in increased expression of IL10 protein]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of IL12B protein]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein]
resiquimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein]		 CTD PMID:18490488 PMID:23890009 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions		 ISO resiquimod results in increased phosphorylation of IKBKB protein
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide promotes the reaction [resiquimod results in increased phosphorylation of IKBKB protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased phosphorylation of IKBKB protein]		 CTD PMID:28924041 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
increases secretion		 ISO [Zymosan co-treated with resiquimod] results in increased expression of IL10 protein; IFNG protein affects the reaction [[Zymosan co-treated with resiquimod] results in increased expression of IL10 protein]; resiquimod promotes the reaction [beta-Glucans results in increased expression of IL10 mRNA]; resiquimod promotes the reaction [beta-Glucans results in increased expression of IL10 protein]
resiquimod results in increased expression of IL10 mRNA
MYD88 gene mutant form inhibits the reaction [resiquimod results in increased expression of IL10 protein]; resiquimod results in increased expression of and results in increased secretion of IL10 protein
resiquimod results in increased secretion of IL10 protein		 CTD PMID:16224278 PMID:17238832 PMID:18490488 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [beta-Glucans co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [beta-Glucans co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; [resiquimod co-treated with Poly I-C] results in increased secretion of [IL12A protein binds to IL12B protein]; [Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]
[resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]		 CTD PMID:15851485 PMID:18490488 PMID:35688559 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12B mRNA; [beta-Glucans co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; [Lipopolysaccharides co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL12B protein]; [Lipopolysaccharides co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; [resiquimod co-treated with Poly I-C] results in increased secretion of [IL12A protein binds to IL12B protein]; [Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; [Zymosan co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; [Zymosan co-treated with resiquimod] results in increased expression of IL12B protein; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of IL12B protein]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein]; resiquimod promotes the reaction [beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]]; resiquimod promotes the reaction [beta-Glucans results in increased expression of IL12B protein]
resiquimod results in increased expression of IL12B protein
[resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]; resiquimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein]; Simvastatin promotes the reaction [resiquimod results in increased expression of IL12B protein]		 CTD PMID:15187114 PMID:15851485 PMID:18490488 PMID:23890009 PMID:35688559 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; resiquimod promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA] CTD PMID:16687389 PMID:23430110 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il21 interleukin 21 increases expression
multiple interactions		 ISO resiquimod results in increased expression of IL21 protein
Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]		 CTD PMID:33632240 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Lipopolysaccharides co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; [Zymosan co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]]; resiquimod promotes the reaction [beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]]; resiquimod promotes the reaction [beta-Glucans results in increased expression of IL23A mRNA] CTD PMID:18490488 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion		 ISO LGMN gene mutant form inhibits the reaction [resiquimod results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]; resiquimod promotes the reaction [deoxynivalenol results in increased expression of IL6 mRNA]
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]; 7-oxozeanol inhibits the reaction [resiquimod results in increased expression of IL6 protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of IL6 protein]
resiquimod results in increased expression of IL6 mRNA; resiquimod results in increased expression of IL6 protein		 CTD PMID:16687389 PMID:22916010 PMID:28924041 PMID:33632240 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases phosphorylation
multiple interactions		 ISO resiquimod results in increased phosphorylation of IRAK4 protein
[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of IL6 protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of TNF protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased phosphorylation of IKBKB protein]		 CTD PMID:28924041 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]; resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]; resiquimod promotes the reaction [IRF5 protein binds to TNF promoter] CTD PMID:28924041 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Lgmn legumain multiple interactions ISO LGMN gene mutant form inhibits the reaction [resiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [resiquimod results in increased secretion of TNF protein] CTD PMID:22916010 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO MYD88 gene mutant form inhibits the reaction [resiquimod results in increased expression of IL10 protein] CTD PMID:17238832 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO resiquimod promotes the reaction [RELA protein binds to CXCL10 promoter]; resiquimod promotes the reaction [RELA protein binds to TNF promoter] CTD PMID:28924041 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sdc1 syndecan 1 increases expression
multiple interactions		 ISO resiquimod results in increased expression of SDC1 protein
Tetrachlorodibenzodioxin inhibits the reaction [resiquimod results in increased expression of SDC1 protein]		 CTD PMID:20348231 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO resiquimod results in increased expression of STAT3 mRNA CTD PMID:17238832 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tlr7 toll-like receptor 7 affects binding
increases activity		 ISO resiquimod binds to TLR7 protein
resiquimod results in increased activity of TLR7 protein		 CTD PMID:15851485 PMID:25780039 PMID:29122671 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 affects binding
increases activity
multiple interactions		 ISO resiquimod binds to TLR8 protein
resiquimod results in increased activity of TLR8 protein
bafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein]		 CTD PMID:15851485 PMID:21398612 PMID:25780039 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions		 ISO resiquimod results in increased expression of TNF mRNA
resiquimod results in increased secretion of TNF protein
resiquimod results in increased expression of TNF mRNA; resiquimod results in increased expression of TNF protein
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased expression of TNF protein]; 7-oxozeanol inhibits the reaction [resiquimod results in increased expression of TNF protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of TNF protein]; resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]; resiquimod promotes the reaction [RELA protein binds to TNF promoter]
LGMN gene mutant form inhibits the reaction [resiquimod results in increased secretion of TNF protein]; resiquimod promotes the reaction [deoxynivalenol results in increased expression of TNF mRNA]		 CTD PMID:16687389 PMID:17238832 PMID:22916010 PMID:28924041 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  imidazoquinoline 179
                    1H-imidazo[4,5-c]quinoline 0
                    2-(acetoxyamino)-3-methylimidazo[4,5-f]quinoline 0
                    3-methyl-3H-imidazo[4,5-f]quinolin-2-amine 38
                    BGT226 free base 0
                    CMB4563 0
                    I-BET151 0
                    NVP-BHS345 0
                    dactolisib 30
                    imiquimod 110
                    resiquimod 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      imidazoquinoline 179
                                        1H-imidazo[4,5-c]quinoline 0
                                        2-(acetoxyamino)-3-methylimidazo[4,5-f]quinoline 0
                                        3-methyl-3H-imidazo[4,5-f]quinolin-2-amine 38
                                        BGT226 free base 0
                                        CMB4563 0
                                        I-BET151 0
                                        NVP-BHS345 0
                                        dactolisib 30
                                        imiquimod 110
                                        resiquimod 24
paths to the root