trihydroxyflavanone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	trihydroxyflavanone	go back to main search page
Accession:	CHEBI:38739	browse the term
Definition:	A hydroxyflavanone carrying three hydroxy substituents.
Synonyms:	related_synonym:	trihydroxyflavanones

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Rat (268 ) Mouse (269 ) Human (279 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (268)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

ISO

naringenin results in increased expression of ABCB1 mRNA
naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

PMID:19148864 PMID:34217736

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

multiple interactions
increases activity

ISO

[Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]

PMID:11306701 PMID:12485947 PMID:16156793

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

multiple interactions

ISO

naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

actin alpha 2, smooth muscle

multiple interactions

EXP

naringenin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adhesion G protein-coupled receptor B1

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA
naringenin metabolite results in increased expression of ADGRB1 mRNA

NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:108,293,818...108,365,870

G

alpha-fetoprotein

affects binding

EXP

naringenin binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aryl hydrocarbon receptor

increases activity
multiple interactions

ISO

naringenin results in increased activity of AHR protein
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]

PMID:17869316 PMID:20450880

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C1

multiple interactions

ISO

naringenin binds to and results in decreased activity of AKR1C1 protein

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

naringenin results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

ISO
EXP

naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
naringenin results in decreased expression of AKT1 mRNA
naringenin inhibits the reaction [lead acetate results in decreased expression of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]

PMID:22692793 PMID:22709785 PMID:25866363 PMID:36807407 PMID:36819991

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions

ISO

naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]

PMID:31063766 PMID:37076581

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of APAF1 mRNA; naringenin results in increased expression of APAF1 protein
[naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of APAF1 mRNA

PMID:27838343 PMID:36235125

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

amyloid beta precursor protein

multiple interactions

EXP

naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 1

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein]

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

aquaporin 5

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

Rho GDP dissociation inhibitor alpha

increases expression

ISO

naringenin results in increased expression of ARHGDIA mRNA; naringenin results in increased expression of ARHGDIA protein

NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ISO

naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

ATM serine/threonine kinase

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ATM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATR serine/threonine kinase

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ATR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

beta-secretase 1

decreases activity

ISO

naringenin results in decreased activity of BACE1 protein

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2-antagonist/killer 1

increases expression

ISO

naringenin results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]
[naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA]

PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BBC3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

butyrylcholinesterase

multiple interactions

ISO

naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
decreases response to substance

ISO
EXP

[naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]
naringenin results in decreased expression of BCL2 mRNA
naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]

PMID:19124070 PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of BCL2A1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

decreases expression

ISO

naringenin results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

brain-derived neurotrophic factor

multiple interactions
increases expression

EXP

naringenin inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]
naringenin results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BIRC5 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BIRC5 mRNA
naringenin metabolite results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BRCA1, DNA repair associated

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA2, DNA repair associated

increases expression
multiple interactions

ISO

naringenin results in increased expression of BRCA2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BRCA2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194

G

BTG anti-proliferation factor 2

decreases expression
multiple interactions

ISO

naringenin metabolite results in decreased expression of BTG2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BTG2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

caspase 2

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CASP2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP2 mRNA
naringenin results in increased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases activity
increases expression
multiple interactions

ISO
EXP

naringenin results in increased activity of CASP3 protein
naringenin results in increased expression of CASP3 mRNA
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
naringenin results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]; naringenin inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; naringenin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]

PMID:19124070 PMID:22692793 PMID:23192364 PMID:27838343 PMID:31254498 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

naringenin results in increased expression of CASP7 protein modified form

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases activity
multiple interactions
increases expression

ISO
EXP

naringenin results in increased activity of CASP9 protein
[naringenin co-treated with bisphenol A] results in increased expression of CASP9 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP9 mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]
naringenin metabolite results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 protein modified form
naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP9 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP9 mRNA]

PMID:19124070 PMID:23192364 PMID:27838343 PMID:31254498 PMID:36235125

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases expression
increases activity

EXP
ISO

naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of CAT protein]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; naringenin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringenin inhibits the reaction [Glucose results in decreased activity of CAT protein]; naringenin inhibits the reaction [lead acetate results in decreased activity of CAT protein]; naringenin inhibits the reaction [Paraquat results in increased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
naringenin inhibits the reaction [Trichloroethylene results in decreased activity of CAT protein]
naringenin results in decreased expression of CAT protein
naringenin analog results in increased activity of CAT protein; naringenin results in increased activity of CAT protein
naringenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:19063931 PMID:19409769 PMID:23192364 PMID:23283742 PMID:23845967 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin B1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA
naringenin results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

decreases expression
multiple interactions

ISO

naringenin results in decreased expression of CCNE1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA

PMID:30153467 PMID:36235125

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin G1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in decreased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin H

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNH mRNA

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860

G

cell division cycle 25A

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDC25A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25A mRNA
naringenin metabolite results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25C

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDC25C mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in decreased expression of CDK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 4

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA
naringenin metabolite results in increased expression of CDKN1A mRNA; naringenin results in increased expression of CDKN1A mRNA

PMID:30153467 PMID:36235125

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

CF transmembrane conductance regulator

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

checkpoint kinase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP

naringenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

CASP2 and RIPK1 domain containing adaptor with death domain

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CRADD mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CRADD mRNA
naringenin results in increased expression of CRADD mRNA

NCBI chr 7:31,827,131...31,839,796
Ensembl chr 7:31,685,622...31,874,512

G

catenin beta 1

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of CTNNB1 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin D

multiple interactions

ISO

[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cytochrome c, somatic

multiple interactions
increases expression

EXP
ISO

naringenin inhibits the reaction [Glucose affects the localization of CYCS protein]
naringenin results in increased expression of CYCS protein

PMID:23192364 PMID:27838343

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO
EXP

naringenin binds to and results in decreased activity of CYP19A1 protein
naringenin results in decreased activity of CYP19A1 protein

PMID:9435150 PMID:15319488 PMID:17895526 PMID:38403145

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases expression

ISO
EXP

naringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
naringenin results in decreased activity of CYP1A1 protein
naringenin results in increased expression of CYP1A1 mRNA
naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]

PMID:11454723 PMID:20930378 PMID:21053930 PMID:27444380

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

naringenin results in decreased activity of CYP1A2 protein

PMID:21053930 PMID:29753067

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

ISO

naringenin binds to and results in decreased activity of CYP1B1 protein
naringenin results in increased expression of CYP1B1 mRNA

PMID:21053930 PMID:31621310

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

naringenin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO
EXP

naringenin results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases expression

ISO

naringenin results in decreased activity of CYP3A4 protein
naringenin results in increased expression of CYP3A4 mRNA

PMID:19148864 PMID:21053930 PMID:29753067

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA methyltransferase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

dopamine receptor D2

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of DRD2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of DRD2 mRNA]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

E2F transcription factor 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of E2F1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of E2F3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

epidermal growth factor receptor

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of EGFR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGFR mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein]

PMID:25866363 PMID:36235125

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of EGR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

estrogen receptor 1

multiple interactions
increases expression
decreases expression
affects binding
increases activity

ISO
EXP

[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein
naringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNA
naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form
naringenin results in increased activity of ESR1 protein

PMID:9751507 PMID:10397250 PMID:10854714 PMID:12650720 PMID:15713566 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression
increases activity
affects binding

ISO
EXP

[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; bisphenol A inhibits the reaction [naringenin metabolite results in increased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [naringenin results in increased expression of ESR2 mRNA]; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]
naringenin metabolite results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 protein
naringenin results in increased activity of ESR2 protein
naringenin binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16118406 PMID:16566672 PMID:17716812 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

Fas associated via death domain

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of FAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FAS mRNA
naringenin metabolite results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of FASLG mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FASLG mRNA
naringenin metabolite results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

naringenin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

forkhead box O3

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

glucose-6-phosphate dehydrogenase

multiple interactions
decreases activity

EXP
ISO

[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]
naringenin results in decreased activity of G6PD protein

PMID:19063931 PMID:25130191 PMID:25228019

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of GADD45A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GADD45A mRNA
naringenin metabolite results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

ISO

NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

naringenin results in increased expression of GCLM protein
NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glycosylphosphatidylinositol anchored molecule like

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of GML mRNA
[naringenin co-treated with bisphenol A] results in increased expression of GML mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GML mRNA

NCBI chr 7:108,578,386...108,601,738

G

G protein-coupled estrogen receptor 1

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein
naringenin metabolite results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 protein

PMID:30153467 PMID:36235125

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

glutamic--pyruvic transaminase

multiple interactions

EXP

[naringenin co-treated with methylmercuric chloride] results in decreased activity of GPT protein; naringenin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein]

PMID:23283742 PMID:29223569 PMID:38308452

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]
naringenin results in decreased expression of GPX1 protein

PMID:23192364 PMID:28395574

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA
naringenin results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 3

multiple interactions

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

glutathione peroxidase 5

increases expression
multiple interactions

ISO

naringenin results in increased expression of GPX5 mRNA
[Paraquat co-treated with naringenin] results in increased expression of GPX5 mRNA

NCBI chr17:48,131,853...48,138,801
Ensembl chr17:48,093,895...48,138,801

G

glutathione peroxidase 7

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX7 mRNA
naringenin results in increased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725

G

glutathione-disulfide reductase

multiple interactions
increases expression

EXP
ISO

naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; naringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA]
Paraquat inhibits the reaction [naringenin results in increased expression of GSR mRNA]

PMID:19063931 PMID:23192364 PMID:24561720

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase zeta 1

multiple interactions
increases expression

ISO

Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA]

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:112,525,377...112,536,233

G

hepatitis A virus cellular receptor 1

multiple interactions

ISO

naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

hexokinase 2

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of HK2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of HK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heme oxygenase 1

multiple interactions
increases expression

EXP
ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin results in increased expression of and results in increased activity of HMOX1 protein; wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]
naringenin results in increased expression of HMOX1 mRNA; naringenin results in increased expression of HMOX1 protein
[Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA
naringenin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]

PMID:15316927 PMID:22709785 PMID:24561720

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

insulin-like growth factor 1 receptor

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of IGF1R mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases expression

ISO

naringenin results in increased expression of IKBKB mRNA

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions

EXP
ISO

naringenin inhibits the reaction [lead acetate results in increased expression of IL1B protein]
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:36807407 PMID:37880698

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of IL6 mRNA
naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]
[naringenin co-treated with bisphenol A] results in increased expression of IL6 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IL6 mRNA

PMID:36235125 PMID:37076581

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha 4

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

ISO

naringenin metabolite results in decreased expression of JUN mRNA; naringenin results in decreased expression of JUN mRNA
naringenin results in increased expression of JUN mRNA

PMID:28395574 PMID:36235125

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysine acetyltransferase 2B

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of KAT2B mRNA
[naringenin co-treated with bisphenol A] results in increased expression of KAT2B mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of KAT2B mRNA

NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

ISO

Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

kinase insert domain receptor

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

KRAS proto-oncogene, GTPase

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNA

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

luteinizing hormone subunit beta

multiple interactions

EXP

naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

lactoperoxidase

increases expression
multiple interactions

ISO

naringenin results in increased expression of LPO mRNA
Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA]

NCBI chr10:73,104,170...73,124,683
Ensembl chr10:73,104,188...73,123,456

G

leucine rich repeat containing 27

increases expression

ISO

naringenin results in increased expression of LRRC27 mRNA; naringenin results in increased expression of LRRC27 protein

NCBI chr 1:203,433,463...203,464,683
Ensembl chr 1:203,434,355...203,464,676

G

leucine-rich repeat kinase 2

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of LRRK2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of LRRK2 mRNA]

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

mitogen-activated protein kinase kinase kinase 5

increases expression

ISO

naringenin results in increased expression of MAP3K5 protein

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase 1

multiple interactions
decreases expression
decreases activity
decreases phosphorylation

EXP
ISO

naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
naringenin results in decreased expression of MAPK1 mRNA
naringenin results in decreased activity of MAPK1 protein
naringenin results in decreased phosphorylation of MAPK1 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]

PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases activity
decreases phosphorylation

EXP
ISO

naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
naringenin results in decreased activity of MAPK3 protein
naringenin results in decreased phosphorylation of MAPK3 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]

PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation

ISO

naringenin results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

increases phosphorylation

ISO

naringenin results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MCL1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

midkine

multiple interactions

EXP

naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743

G

MDM2 proto-oncogene

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA
naringenin metabolite results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MDM4 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM4 mRNA

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

microRNA 141

decreases expression

ISO

naringenin metabolite results in decreased expression of MIR141 mRNA

NCBI chr 4:159,209,525...159,209,618

G

microRNA 200c

multiple interactions

ISO

naringenin inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]; naringenin metabolite inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]

NCBI chr 4:159,209,965...159,210,033

G

mutL homolog 1

increases expression
multiple interactions

ISO

naringenin results in increased expression of MLH1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MLH1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MLH1 mRNA

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011

G

matrix metallopeptidase 2

decreases expression
multiple interactions

ISO

naringenin results in decreased expression of MMP2 mRNA
naringenin results in decreased expression of and results in decreased activity of MMP2 protein

PMID:30153467 PMID:30431227

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringenin results in decreased expression of and results in decreased activity of MMP9 protein
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]
naringenin results in decreased expression of MMP9 mRNA

PMID:25866363 PMID:30153467 PMID:30431227 PMID:37880698

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mutS homolog 2

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of MSH2 mRNA

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

naringenin inhibits the reaction [lead acetate results in decreased expression of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

myogenic differentiation 1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of MYOD1 mRNA; naringenin results in increased expression of MYOD1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MYOD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

Nanog homeobox

decreases expression

ISO

naringenin results in decreased expression of NANOG protein

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

neurofibromin 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of NF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases activity
increases expression

ISO

[naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; naringenin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]
naringenin results in increased activity of NFE2L2 protein
naringenin results in increased expression of NFE2L2 mRNA

PMID:24561720 PMID:31254498

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of NFKB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

ISO

naringenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor like 1

increases expression

ISO

naringenin results in increased expression of NFKBIL1 mRNA; naringenin results in increased expression of NFKBIL1 protein

NCBI chr20:3,595,319...3,610,295
Ensembl chr20:3,595,284...3,610,294

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

ISO

naringenin results in increased expression of NME1 mRNA; naringenin results in increased expression of NME1 protein

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

nitric oxide synthase 2

multiple interactions

ISO

Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:10188978 PMID:12512693 PMID:15316927 PMID:18274639

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA
naringenin results in increased expression of NQO1 mRNA; naringenin results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

naringenin results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

naringenin results in increased cleavage of PARP1 protein
naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]

PMID:27838343 PMID:31254498

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PCNA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphogluconate dehydrogenase

decreases activity

ISO

naringenin results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

progesterone receptor

increases expression
multiple interactions

EXP
ISO

naringenin results in increased expression of PGR mRNA
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA

PMID:10397250 PMID:24586459

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

p53-induced death domain protein 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PIDD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

paraoxonase 1

increases expression

ISO

naringenin results in increased expression of PON1 mRNA

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP
ISO

HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

multiple interactions

ISO
EXP

naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARB protein]
HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP
ISO

HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein]

PMID:29223569 PMID:31063766

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

peroxiredoxin 1

decreases expression

ISO

naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein kinase C, alpha

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PRKCA mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]

PMID:25866363 PMID:36235125

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

multiple interactions

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, gamma

multiple interactions

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein]

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814

G

prominin 1

decreases expression

ISO

naringenin results in decreased expression of PROM1 protein

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

presenilin 2

multiple interactions

ISO

[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA

NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116

G

phosphatase and tensin homolog

multiple interactions
increases expression

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTEN mRNA
naringenin results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 1

increases expression

ISO

naringenin results in increased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of PTGS2 protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]

PMID:21341175 PMID:25855085 PMID:27206700

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

PTTG1 regulator of sister chromatid separation, securin

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of PTTG1 mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RB transcriptional corepressor 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of RELA protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

PMID:18274639 PMID:25855085 PMID:27206700 PMID:36731809

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reprimo, TP53 dependent G2 arrest mediator homolog

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA
naringenin metabolite results in increased expression of RPRM mRNA; naringenin results in increased expression of RPRM mRNA

NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:58,799,866...58,950,542

G

regulatory associated protein of MTOR, complex 1

increases expression

ISO

naringenin results in increased expression of RPTOR mRNA; naringenin results in increased expression of RPTOR protein

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413

G

serpin family E member 1

multiple interactions

EXP

naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sestrin 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of SESN2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

sex hormone binding globulin

affects binding

ISO

naringenin binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

sucrase-isomaltase

decreases activity
multiple interactions

EXP
ISO

naringenin results in decreased activity of SI protein
naringenin binds to and results in decreased activity of SI protein

NCBI chr 2:159,804,568...159,884,902
Ensembl chr 2:159,804,568...159,883,934

G

siah E3 ubiquitin protein ligase 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of SIAH1 mRNA

NCBI chr19:36,552,165...36,575,773
Ensembl chr19:36,540,947...36,581,541

G

sirtuin 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 16 member 1

multiple interactions

ISO
EXP

naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
[naringenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

PMID:17108059 PMID:17976262

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 2 member 1

multiple interactions
decreases activity

ISO

naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
naringenin results in decreased activity of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 4

multiple interactions

EXP

naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 5 member 1

multiple interactions

ISO

naringenin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 6 member 3

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of SLC6A3 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of SLC6A3 mRNA]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

snail family transcriptional repressor 1

decreases expression

ISO

naringenin results in decreased expression of SNAI1 protein

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

decreases expression

ISO

naringenin results in decreased expression of SNAI2 protein

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synuclein alpha

multiple interactions
increases expression

EXP

naringenin inhibits the reaction [Paraquat results in increased expression of SNCA mRNA]
naringenin results in increased expression of SNCA mRNA

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

suppressor of cytokine signaling 3

increases expression

ISO

naringenin results in increased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA]
naringenin results in decreased expression of SOD1 protein

PMID:23192364 PMID:28395574

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 2

decreases expression

ISO

naringenin results in decreased expression of SOX2 protein

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

secreted phosphoprotein 1

multiple interactions

EXP

naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

signal transducer and activator of transcription 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

naringenin results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

sulfotransferase family 1A member 1

multiple interactions

ISO
EXP

Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin]

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

transcriptional adaptor 3

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of TADA3 mRNA

NCBI chr 4:148,065,859...148,077,347
Ensembl chr 4:148,065,877...148,077,320

G

TEK receptor tyrosine kinase

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

transforming growth factor, beta 1

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
naringenin inhibits the reaction [lead acetate results in increased expression of TGFB1 protein]

PMID:23845967 PMID:36807407

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

multiple interactions
decreases expression

EXP

naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein]
naringenin results in decreased expression of TH protein

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

multiple interactions
increases expression
decreases activity

ISO
EXP

[naringenin co-treated with bisphenol A] results in increased expression of TNF mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNF mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
naringenin metabolite results in increased expression of TNF mRNA
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]
naringenin results in decreased activity of TNF protein
naringenin inhibits the reaction [lead acetate results in increased expression of TNF protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]

PMID:18720166 PMID:19135038 PMID:22709785 PMID:36235125 PMID:36807407 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with naringenin] results in increased expression of TP53 mRNA; naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; naringenin results in increased expression of and results in increased phosphorylation of TP53 protein
naringenin results in increased expression of TP53 mRNA

PMID:15795422 PMID:27838343 PMID:30153467

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein, 2

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53BP2 mRNA

NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616

G

tumor protein p63

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TP63 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP63 mRNA
naringenin metabolite results in increased expression of TP63 mRNA; naringenin results in increased expression of TP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

tumor protein p73

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of TP73 mRNA; naringenin results in increased expression of TP73 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of TP73 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

thyroid peroxidase

decreases activity

EXP

naringenin results in decreased activity of TPO protein

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

Tnf receptor-associated factor 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TRAF2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

TSC complex subunit 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TSC1 mRNA

NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568

G

uncoupling protein 1

multiple interactions

EXP

naringenin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

ISO

UGT1A1 protein results in increased glucuronidation of naringenin
naringenin results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:31621310

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of naringenin

PMID:14557274 PMID:18816295

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

EXP

UGT2B15 protein results in increased metabolism of naringenin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467

G

vascular endothelial growth factor A

multiple interactions

ISO
EXP

naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]
naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

PMID:36731809 PMID:37076581

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WT1 transcription factor

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of WT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of WT1 mRNA
naringenin metabolite results in increased expression of WT1 mRNA

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

G

xanthine dehydrogenase

multiple interactions

EXP

naringenin inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-ray repair cross complementing 5

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293

6-prenylnaringenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

6-prenylnaringenin results in increased expression of CYP1A1 mRNA; 6-prenylnaringenin results in increased expression of CYP1A1 protein
6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; 6-prenylnaringenin inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA]

PMID:27269377 PMID:32986415

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

ISO

6-prenylnaringenin results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

DNA methyltransferase 1

multiple interactions

ISO

6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

estrogen receptor 1

multiple interactions
decreases expression

ISO

2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]; 6-prenylnaringenin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

eriocitrin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

eriocitrin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 7

increases expression

ISO

eriocitrin results in increased expression of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases expression

ISO

eriocitrin results in increased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin D1

decreases expression

ISO

eriocitrin results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

Janus kinase 2

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

proliferating cell nuclear antigen

decreases expression

ISO

eriocitrin results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

actin alpha 2, smooth muscle

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

hesperetin results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

aryl hydrocarbon receptor

increases activity
multiple interactions

ISO

hesperetin results in increased activity of AHR protein
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]

PMID:17869316 PMID:21720915

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

multiple interactions

EXP

hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions

EXP

hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 4 family, member A1

affects binding

ISO

hesperetin binds to ALDH4A1 protein

NCBI chr 5:157,163,189...157,188,673
Ensembl chr 5:157,162,945...157,188,673

G

apurinic/apyrimidinic endodeoxyribonuclease 1

affects binding

ISO

hesperetin binds to APEX1 protein

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

autophagy related 5

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of ATG5 mRNA]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

ISO
EXP

hesperetin affects the expression of BAX protein
[Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]
hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein
hesperetin analog results in increased expression of BAX mRNA

PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

affects expression
multiple interactions
decreases expression

ISO
EXP

hesperetin affects the expression of BCL2 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein
hesperetin analog results in decreased expression of BCL2 mRNA

PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 PMID:37487865

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of BECN1 mRNA]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity

ISO
EXP

hesperetin affects the cleavage of CASP3 protein
hesperetin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form
hesperetin analog results in increased activity of CASP3 protein
hesperetin analog results in increased expression of CASP3 mRNA

PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

increases activity
multiple interactions
decreases activity

ISO
EXP

hesperetin results in increased activity of CAT protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 5

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin D1

decreases expression
multiple interactions

ISO
EXP

hesperetin results in decreased expression of CCND1
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]

PMID:17927510 PMID:27818223

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

copper chaperone for superoxide dismutase

affects binding

ISO

hesperetin binds to CCS protein

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260

G

cyclin dependent kinase 2

decreases expression

ISO

hesperetin results in decreased expression of CDK2

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

multiple interactions
decreases expression

ISO

hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in decreased expression of CDK4

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA

PMID:17927510 PMID:25345581

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

hesperetin results in increased expression of CDKN1B

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

hesperetin results in decreased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

collagen type I alpha 1 chain

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

colony stimulating factor 3

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cytochrome b5 type A

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein]

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome c, somatic

increases expression

ISO

hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

hesperetin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO

[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
hesperetin results in decreased activity of CYP1A1 protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]

PMID:10781868 PMID:21720915 PMID:26546711

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

hesperetin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

hesperetin results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

hesperetin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

deleted in azoospermia-like

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of DAZL mRNA]

NCBI chr 9:18,193,363...18,210,100
Ensembl chr 9:18,193,363...18,210,100

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

ISO

hesperetin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dynamin 1-like

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

fatty acid binding protein 4

decreases expression

ISO

hesperetin results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP

hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutathione peroxidase 4

affects binding

ISO

hesperetin binds to GPX4 protein

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of GSR protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]

PMID:21134734 PMID:26546711 PMID:35567572

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

heme oxygenase 1

increases expression
multiple interactions

ISO

hesperetin results in increased expression of HMOX1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]

PMID:15316927 PMID:31153982

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

ISO

hesperetin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 alpha

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
affects expression

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
hesperetin affects the expression of IL1B protein

PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
affects expression

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]
hesperetin affects the expression of IL6 protein

PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Janus kinase 1

multiple interactions

ISO

hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Kelch-like ECH-associated protein 1

affects binding

ISO

hesperetin binds to KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

lipoprotein lipase

decreases expression

ISO

hesperetin results in decreased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

mitogen activated protein kinase 1

multiple interactions

ISO

hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP
ISO

hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
[Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]

PMID:19222219 PMID:31153982

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

microRNA 150

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR150 mRNA]

NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571

G

microRNA 181b-2

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR181B2 mRNA]

NCBI chr 3:43,026,666...43,026,753
Ensembl chr 3:43,026,666...43,026,753

G

microRNA 410

multiple interactions

ISO

hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]

NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839

G

myeloperoxidase

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:31153982 PMID:33522063

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

EXP

hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

ISO

hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein
hesperetin results in increased expression of NFE2L2 protein

PMID:26546711 PMID:31153982

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]

PMID:12512693 PMID:15316927 PMID:35567572

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NADPH oxidase 4

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of NOX4 protein
hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

EXP
ISO

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein]
hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein
hesperetin results in increased expression of NQO1 protein

PMID:19497424 PMID:31153982

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects binding

ISO

hesperetin binds to NQO2 protein

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

hesperetin results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of PCNA mRNA]

PMID:26546711 PMID:34933056

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 6 interacting protein

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of PDCD6IP protein
Acetylcysteine inhibits the reaction [hesperetin results in decreased expression of PDCD6IP protein]

NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993

G

cytochrome p450 oxidoreductase

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein]

PMID:25345581 PMID:28428136

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

phosphatase and tensin homolog

multiple interactions

EXP

hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

multiple interactions
affects activity

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
hesperetin affects the activity of PTGS2 protein

PMID:15240993 PMID:16101151 PMID:35567572

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]

PMID:26546711 PMID:35567572

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

resistin

decreases expression

ISO

hesperetin results in decreased expression of RETN mRNA

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116

G

sex hormone binding globulin

affects binding

ISO

hesperetin binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

sirtuin 3

affects binding

ISO

hesperetin binds to SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

sirtuin 6

multiple interactions
increases expression

ISO

[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein
hesperetin results in increased expression of SIRT6 protein

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542

G

solute carrier family 16 member 1

multiple interactions

EXP

[hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

suppressor of cytokine signaling 3

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

increases expression

ISO

hesperetin results in increased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression

ISO

hesperetin results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 18

multiple interactions

ISO

hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]

NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802

G

signal transducer and activator of transcription 1

multiple interactions

ISO

hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

PMID:27818223 PMID:34922902

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
affects expression
decreases expression

ISO
EXP

[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
hesperetin affects the expression of TNF protein
hesperetin results in decreased expression of TNF mRNA

PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [hesperetin results in increased expression of TP53 protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]

PMID:15795422 PMID:37487865

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

affects binding

ISO

hesperetin binds to UQCRFS1 protein

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950

G

utrophin

increases expression

ISO

hesperetin results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

homoeriodictyol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

BCL2, apoptosis regulator

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

homoeriodictyol results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

homoeriodictyol results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

homoeriodictyol results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

ghrelin and obestatin prepropeptide

multiple interactions

ISO

[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

homoeriodictyol results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bcl2-like 1

decreases expression
multiple interactions

ISO

kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

increases activity
multiple interactions

ISO

kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cyclin D1

decreases expression

ISO

kurarinol results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

ISO

kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

Naringenin increases expression of NR1H3 mRNA and protein in macrophages

RGD

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

ISO

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

collagen type I alpha 1 chain

multiple interactions
increases expression

ISO

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

RUNX family transcription factor 2

increases expression

ISO

neoeriocitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

sophoraflavanone B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression
increases activity

ISO

[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
8-prenylnaringenin results in increased expression of ALPL mRNA
8-prenylnaringenin results in increased activity of ALPL protein

PMID:12650720 PMID:16019205

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

complement C3

increases expression

EXP

8-prenylnaringenin results in increased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

carbonyl reductase 1

multiple interactions

ISO

8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; 8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

glycoprotein hormones, alpha polypeptide

decreases expression

EXP

8-prenylnaringenin results in decreased expression of CGA mRNA

NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464

G

casein beta

increases expression
multiple interactions

EXP

8-prenylnaringenin results in increased expression of CSN2 mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of CSN2 mRNA]

NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
decreases expression

ISO

8-prenylnaringenin results in decreased activity of CYP1A1 protein
8-prenylnaringenin results in decreased expression of CYP1A1 mRNA

PMID:19770484 PMID:32986415

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression

ISO

8-prenylnaringenin results in decreased activity of CYP1A2 protein
8-prenylnaringenin results in increased expression of CYP1A2 mRNA

PMID:15672752 PMID:19770484

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

8-prenylnaringenin results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

estrogen receptor 1

multiple interactions
decreases expression
increases expression
increases activity

ISO
EXP

8-prenylnaringenin analog binds to and results in increased activity of ESR1 protein; 8-prenylnaringenin binds to and results in increased activity of ESR1 protein; [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
8-prenylnaringenin results in increased expression of ESR1 mRNA
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]
8-prenylnaringenin results in increased activity of ESR1 protein

PMID:12623674 PMID:12650720 PMID:15876408 PMID:16076101 PMID:17149865 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

decreases expression
multiple interactions
increases expression
increases activity

EXP
ISO

8-prenylnaringenin results in decreased expression of ESR2 mRNA
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR2 mRNA
8-prenylnaringenin results in increased expression of ESR2 mRNA
8-prenylnaringenin analog binds to and results in decreased activity of ESR2 protein; 8-prenylnaringenin binds to and results in increased activity of ESR2 protein
8-prenylnaringenin results in increased activity of ESR2 protein

PMID:16076101 PMID:16522720 PMID:17149865 PMID:17716812 PMID:34848279

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

follicle stimulating hormone subunit beta

decreases expression

EXP

8-prenylnaringenin results in decreased expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

gonadotropin releasing hormone receptor

decreases expression

EXP

8-prenylnaringenin results in decreased expression of GNRHR mRNA

NCBI chr14:22,211,666...22,229,654

G

insulin-like growth factor 1

multiple interactions

EXP

[Fulvestrant co-treated with 8-prenylnaringenin] results in decreased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

increases expression

EXP

8-prenylnaringenin results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

interleukin 6

decreases expression

ISO

8-prenylnaringenin results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinesin family member 11

multiple interactions
increases expression

EXP

Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 18A

increases expression
multiple interactions

EXP

8-prenylnaringenin results in increased expression of KIF18A mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF18A mRNA]

NCBI chr 3:116,219,007...116,279,378
Ensembl chr 3:116,219,007...116,279,227

G

kinesin family member 2C

increases expression

EXP

8-prenylnaringenin results in increased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

luteinizing hormone subunit beta

decreases expression

EXP

8-prenylnaringenin results in decreased expression of LHB mRNA; 8-prenylnaringenin results in decreased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

marker of proliferation Ki-67

decreases expression

EXP

8-prenylnaringenin results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

progesterone receptor

increases expression
multiple interactions

ISO
EXP

8-prenylnaringenin results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [8-prenylnaringenin results in increased expression of PGR mRNA]
8-prenylnaringenin results in increased expression of PGR mRNA; 8-prenylnaringenin results in increased expression of PGR protein

PMID:16076101 PMID:16522720 PMID:16837889 PMID:34848279

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

prolactin

increases expression

EXP

8-prenylnaringenin results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

trefoil factor 1

increases expression

ISO

8-prenylnaringenin results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

von Willebrand factor

increases expression

ISO

8-prenylnaringenin results in increased expression of VWF mRNA

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
molecular entity	20871
polyatomic entity	20745
heteroatomic molecular entity	20606
hydroxides	19922
organic hydroxy compound	19685
hydroxyflavanone	579
trihydroxyflavanone	268
(-)-(2S)-5,7,2'-trihydroxy-5'-(1''',1'''-dimethylallyl)-8-prenylflavanone	0
(-)-(2S)-5,7,2'-trihydroxy-8,3'-diprenylflavanone	0
(2S)-(-)-kurarinone	0
(2S)-2'-hydroxydemethoxymatteucinol	0
(2S)-5,7,3',5'-tetrahydroxyflavanone-7-O-beta-D-glucopyranoside	0
(2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone	0
(2S)-carthamidin-7-methyl ether	0
(2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid	0
(2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside	0
(2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone	0
2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one +	0
5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone	0
5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone	0
6,7,4'-trihydroxyflavanone	0
6,8-diprenylnaringenin	0
6-methoxyaromadendrin 3-O-acetate	0
6-prenylnaringenin	4
abyssinone V	0
butin	0
eriocitrin	10
eriodictyol 7-O-beta-D-glucopyranoside	0
eriosemaone C	0
euchrenone-a7	0
exiguaflavanone B	0
fustin 3-O-beta-D-galactoside	0
garbanzol	0
glepidotin B	0
guangsangon M	0
guangsangon N	0
hesperetin	93
homoeriodictyol	21
isohemiphloin	0
kurarinol	5
leachianone A	0
lespeflorin B2	0
lespeflorin B3	0
macaflavanone G	0
monotesone A	0
myrciacitrin I	0
myrciacitrin III	0
myrciacitrin IV	0
myrciacitrin V	0
naringenin +	204
neocarthamin	0
neoeriocitrin	3
phellamurin	0
pinobanksin	0
pisonivanone	0
remangiflavanone A	0
schizolaenone A	0
sophoraflavanone A	0
sophoraflavanone B	24
sophoraflavanone L	0
tanariflavanone B	0
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
organic heterocyclic compound	19381
oxacycle	18273
benzopyran	10790
1-benzopyran	10376
flavans	3662
flavanones	597
hydroxyflavanone	579
trihydroxyflavanone	268
(-)-(2S)-5,7,2'-trihydroxy-5'-(1''',1'''-dimethylallyl)-8-prenylflavanone	0
(-)-(2S)-5,7,2'-trihydroxy-8,3'-diprenylflavanone	0
(2S)-(-)-kurarinone	0
(2S)-2'-hydroxydemethoxymatteucinol	0
(2S)-5,7,3',5'-tetrahydroxyflavanone-7-O-beta-D-glucopyranoside	0
(2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone	0
(2S)-carthamidin-7-methyl ether	0
(2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid	0
(2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside	0
(2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone	0
2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one +	0
5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone	0
5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone	0
6,7,4'-trihydroxyflavanone	0
6,8-diprenylnaringenin	0
6-methoxyaromadendrin 3-O-acetate	0
6-prenylnaringenin	4
abyssinone V	0
butin	0
eriocitrin	10
eriodictyol 7-O-beta-D-glucopyranoside	0
eriosemaone C	0
euchrenone-a7	0
exiguaflavanone B	0
fustin 3-O-beta-D-galactoside	0
garbanzol	0
glepidotin B	0
guangsangon M	0
guangsangon N	0
hesperetin	93
homoeriodictyol	21
isohemiphloin	0
kurarinol	5
leachianone A	0
lespeflorin B2	0
lespeflorin B3	0
macaflavanone G	0
monotesone A	0
myrciacitrin I	0
myrciacitrin III	0
myrciacitrin IV	0
myrciacitrin V	0
naringenin +	204
neocarthamin	0
neoeriocitrin	3
phellamurin	0
pinobanksin	0
pisonivanone	0
remangiflavanone A	0
schizolaenone A	0
sophoraflavanone A	0
sophoraflavanone B	24
sophoraflavanone L	0
tanariflavanone B	0

paths to the root