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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monocrotophos
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Accession:CHEBI:38728 term browser browse the term
Definition:An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate.
Synonyms:related_synonym: (E)-monocrotophos;   Azodrin;   Dimethyl (E)-1-methyl-2-(methylcarbamoyl)vinyl phosphate;   Dimethyl (E)-3-hydroxy-N-methylcrotonamide;   Phosphoric acid, dimethyl (E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl ester;   dimethyl (1E)-1-methyl-3-(methylamino)-3-oxoprop-1-en-1-yl phosphate
 xref: Beilstein:2331934;   CAS:6923-22-4;   HMDB:HMDB0031805
 xref_mesh: MESH:D008999
 xref: PPDB:1111;   Reaxys:8415832;   kegg.compound:C18663;   pubmed:23010531;   pubmed:23228476;   pubmed:23948368;   pubmed:24105069;   pubmed:24440807;   wikipedia.en:Monocrotophos
 chemrof_formula: C7H14NO5P
 chemrof_smiles: CNC(=O)/C=C(C)OP(=O)(OC)OC
 chemrof_inchi: InChI=1S/C7H14NO5P/c1-6(5-7(9)8-2)13-14(10,11-3)12-4/h5H,1-4H3,(H,8,9)/b6-5+
 chemrof_inchikey: KRTSDMXIXPKRQR-AATRIKPKSA-N


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monocrotophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Monocrotophos results in increased expression of ABCA1 mRNA CTD PMID:32267039 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression
increases activity 		EXP Monocrotophos results in increased expression of ACACA mRNA
Monocrotophos results in increased activity of ACACA protein 		CTD PMID:32207356 PMID:32267039 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
decreases expression 		ISO
EXP 		asoxime chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]
[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein
Monocrotophos results in decreased expression of ACHE mRNA 		CTD PMID:8783813 PMID:15679473 PMID:15793557 PMID:19730754 PMID:20026515 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Monocrotophos results in decreased expression of ADIPOQ protein CTD PMID:32207356 PMID:32267039 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
increases expression 		ISO Monocrotophos affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein
Monocrotophos results in increased expression of AHR mRNA 		CTD PMID:22733800 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases expression 		ISO Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]
Monocrotophos results in decreased expression of AIFM1 protein 		CTD PMID:33078895 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions
increases expression 		ISO Monocrotophos results in increased expression of and affects the localization of APEX1 protein
Monocrotophos results in increased expression of APEX1 mRNA 		CTD PMID:28887667 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP Monocrotophos results in increased expression of and affects the localization of BAX protein; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]
Monocrotophos results in increased expression of BAX mRNA; Monocrotophos results in increased expression of BAX protein 		CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP Monocrotophos results in increased expression of BBC3 mRNA CTD PMID:20957986 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Monocrotophos results in decreased activity of BCHE protein CTD PMID:19730754 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions 		EXP Monocrotophos results in increased expression of BCL2 mRNA; Monocrotophos results in increased expression of BCL2 protein
Monocrotophos results in decreased expression of BCL2 mRNA; Monocrotophos results in decreased expression of BCL2 protein
resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein] 		CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Monocrotophos results in decreased expression of BCL2L2 mRNA; Monocrotophos results in decreased expression of BCL2L2 protein CTD PMID:20957986 PMID:21445290 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		EXP Monocrotophos results in increased expression of CASP3 mRNA; Monocrotophos results in increased expression of CASP3 protein; Monocrotophos results in increased expression of CASP3 protein modified form
resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 protein] 		CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases expression EXP Monocrotophos results in increased expression of CASP9 mRNA; Monocrotophos results in increased expression of CASP9 protein; Monocrotophos results in increased expression of CASP9 protein modified form CTD PMID:20957986 PMID:21445290 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase decreases activity EXP Monocrotophos results in decreased activity of CAT protein CTD PMID:22751200 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Monocrotophos results in increased expression of CDKN1A mRNA; Monocrotophos results in increased expression of CDKN1A protein CTD PMID:20957986 PMID:21445290 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression 		EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of COX4I1 mRNA] CTD PMID:35403558 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Monocrotophos results in increased expression of and affects the localization of CYCS protein CTD PMID:20957986 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
multiple interactions 		EXP
ISO 		Monocrotophos results in increased expression of CYP1A1 protein
Monocrotophos results in increased activity of CYP1A1 protein
Monocrotophos results in increased expression of CYP1A1 mRNA; Monocrotophos results in increased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein 		CTD PMID:21445290 PMID:22733800 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Monocrotophos results in increased expression of CYP1A2 protein CTD PMID:21445290 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Monocrotophos results in increased expression of CYP2B2 protein CTD PMID:21445290 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
multiple interactions
increases expression 		ISO Monocrotophos results in increased activity of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein
Monocrotophos results in increased expression of CYP2B6 mRNA; Monocrotophos results in increased expression of CYP2B6 protein 		CTD PMID:22733800 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
increases activity
multiple interactions 		EXP
ISO 		Monocrotophos results in increased expression of CYP2E1 protein
Monocrotophos results in increased activity of CYP2E1 protein
Monocrotophos results in increased expression of CYP2E1 mRNA; Monocrotophos results in increased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein 		CTD PMID:21445290 PMID:22733800 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions 		ISO Monocrotophos results in increased activity of CYP3A4 protein
Monocrotophos results in increased expression of CYP3A4 mRNA; Monocrotophos results in increased expression of CYP3A4 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein 		CTD PMID:22733800 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP Monocrotophos results in increased expression of CYP7A1 mRNA CTD PMID:32267039 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression EXP Monocrotophos results in increased expression of DGAT1 mRNA CTD PMID:32207356 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Fasn fatty acid synthase increases activity
increases expression 		EXP Monocrotophos results in increased activity of FASN protein
Monocrotophos results in increased expression of FASN mRNA 		CTD PMID:32207356 PMID:32267039 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Monocrotophos results in increased expression of FOS protein CTD PMID:20957986 PMID:21445290 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects activity
multiple interactions
increases activity 		EXP Monocrotophos affects the activity of G6PD protein
[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein
Monocrotophos results in increased activity of G6PD protein 		CTD PMID:24248738 PMID:32207356 PMID:32267039 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases activity EXP Monocrotophos results in increased activity of GAPDH protein CTD PMID:32207356 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gck glucokinase increases activity EXP Monocrotophos results in increased activity of GCK protein CTD PMID:32267039 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
affects activity
multiple interactions 		EXP Monocrotophos results in decreased activity of GSR protein
Monocrotophos affects the activity of GSR protein
[Monocrotophos co-treated with quinalphos] affects the activity of GSR protein 		CTD PMID:22751200 PMID:24248738 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions 		EXP
ISO 		Monocrotophos results in increased expression of GSTP1 mRNA; Monocrotophos results in increased expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein 		CTD PMID:21445290 PMID:22733800 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP Monocrotophos results in increased expression of HMGCR mRNA CTD PMID:32267039 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Monocrotophos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Ins1 insulin 1 increases expression EXP Monocrotophos results in increased expression of INS1 protein CTD PMID:32207356 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		EXP
ISO 		Monocrotophos results in increased expression of JUN protein
Monocrotophos results in increased expression of and results in increased phosphorylation of JUN protein 		CTD PMID:20957986 PMID:21445290 PMID:28887667 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression EXP Monocrotophos results in increased expression of LDLR mRNA CTD PMID:32267039 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Lep leptin increases expression EXP Monocrotophos results in increased expression of LEP protein CTD PMID:32207356 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lig3 DNA ligase 3 increases expression ISO Monocrotophos results in increased expression of LIG3 mRNA CTD PMID:28887667 NCBI chr10:68,215,371...68,238,705
Ensembl chr10:68,215,407...68,238,704 		JBrowse link
G Lpin1 lipin 1 increases activity
affects expression 		EXP Monocrotophos results in increased activity of LPIN1 protein
Monocrotophos affects the expression of LPIN1 mRNA 		CTD PMID:32207356 PMID:32267039 NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991 		JBrowse link
G Lpl lipoprotein lipase increases expression
decreases activity 		EXP Monocrotophos results in increased expression of LPL mRNA
Monocrotophos results in decreased activity of LPL protein 		CTD PMID:32207356 PMID:32267039 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP Monocrotophos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Maob monoamine oxidase B decreases activity EXP Monocrotophos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Monocrotophos results in decreased expression of MCL1 mRNA; Monocrotophos results in decreased expression of MCL1 protein CTD PMID:20957986 PMID:21445290 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression 		EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND1 mRNA] CTD PMID:35403558 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 decreases expression
multiple interactions 		EXP Monocrotophos results in decreased expression of ND2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND2 mRNA] 		CTD PMID:35403558 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,892...4,929 		JBrowse link
G Nes nestin decreases expression
increases expression 		ISO Monocrotophos results in decreased expression of NES mRNA
Monocrotophos results in increased expression of NES protein 		CTD PMID:33569802 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
decreases expression 		ISO
EXP 		Monocrotophos results in increased expression of NFE2L2 protein
Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]
Monocrotophos results in decreased expression of NFE2L2 mRNA 		CTD PMID:28887667 PMID:33078895 PMID:35403558 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression
multiple interactions 		ISO Monocrotophos affects the expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein 		CTD PMID:22733800 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases expression
increases expression 		ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
Monocrotophos results in decreased expression of NR1I3 protein
Monocrotophos results in increased expression of NR1I3 mRNA; Monocrotophos results in increased expression of NR1I3 protein 		CTD PMID:22733800 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
decreases expression 		EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of NRF1 mRNA] CTD PMID:35403558 NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO Monocrotophos results in decreased expression of OGG1 mRNA CTD PMID:28887667 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Monocrotophos results in increased expression of PARP1 mRNA; Monocrotophos results in increased expression of PARP1 protein CTD PMID:28887667 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Monocrotophos results in decreased expression of PPARA mRNA CTD PMID:32267039 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Monocrotophos results in increased expression of PPARG mRNA CTD PMID:32207356 PMID:32267039 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions 		EXP Monocrotophos results in decreased expression of PPARGC1A mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of PPARGC1A mRNA] 		CTD PMID:35403558 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression EXP Monocrotophos results in increased expression of SCARB1 mRNA CTD PMID:32267039 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions 		EXP Monocrotophos results in decreased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of SOD2 mRNA] 		CTD PMID:35403558 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Monocrotophos results in increased expression of SREBF1 mRNA CTD PMID:32207356 PMID:32267039 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP Monocrotophos results in increased expression of SREBF2 mRNA CTD PMID:32267039 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO [perfluorooctanoic acid co-treated with Monocrotophos] results in decreased expression of TAC1 mRNA CTD PMID:33569802 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
decreases expression 		EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of TFAM mRNA] CTD PMID:35403558 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity 		EXP Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP Monocrotophos results in increased expression of TNF protein CTD PMID:32207356 PMID:32267039 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Monocrotophos results in increased expression of TP53 mRNA; Monocrotophos results in increased expression of TP53 protein; Monocrotophos results in increased expression of TRP53 mRNA; Monocrotophos results in increased expression of TRP53 protein CTD PMID:20957986 PMID:21445290 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        agrochemical 16228
          monocrotophos 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      pnictogen 19695
                        phosphorus atom 14760
                          phosphorus molecular entity 14760
                            phosphorus oxoacids and derivatives 14745
                              phosphorus oxoacid derivative 14118
                                phosphoric acid derivative 13866
                                  phosphate 13865
                                    organic phosphate 13865
                                      alkyl phosphate 8100
                                        dialkyl phosphate 7646
                                          monocrotophos 66
paths to the root