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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monocrotophos
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Accession:CHEBI:38728 term browser browse the term
Definition:An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate.
Synonyms:exact_synonym: dimethyl (1E)-1-methyl-3-(methylamino)-3-oxoprop-1-en-1-yl phosphate
 related_synonym: (E)-monocrotophos;   Azodrin;   Dimethyl (E)-1-methyl-2-(methylcarbamoyl)vinyl phosphate;   Dimethyl (E)-3-hydroxy-N-methylcrotonamide;   Formula=C7H14NO5P;   InChI=1S/C7H14NO5P/c1-6(5-7(9)8-2)13-14(10,11-3)12-4/h5H,1-4H3,(H,8,9)/b6-5+;   InChIKey=KRTSDMXIXPKRQR-AATRIKPKSA-N;   Phosphoric acid, dimethyl (E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl ester;   SMILES=CNC(=O)\\C=C(/C)OP(=O)(OC)OC
 xref: Beilstein:2331934;   CAS:6923-22-4;   HMDB:HMDB0031805;   KEGG:C18663
 xref_mesh: MESH:D008999
 xref: PMID:23010531;   PMID:23228476;   PMID:23948368;   PMID:24105069;   PMID:24440807;   PPDB:1111;   Reaxys:8415832;   Wikipedia:Monocrotophos


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monocrotophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Monocrotophos results in increased expression of ABCA1 mRNA CTD PMID:32267039 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression
increases activity		 EXP Monocrotophos results in increased expression of ACACA mRNA
Monocrotophos results in increased activity of ACACA protein		 CTD PMID:32267039 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
decreases expression		 ISO
EXP		 asoxime chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]
[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein
Monocrotophos results in decreased expression of ACHE mRNA		 CTD PMID:8783813 PMID:15679473 PMID:15793557 PMID:19730754 PMID:20026515 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Monocrotophos results in decreased expression of ADIPOQ protein CTD PMID:32267039 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
increases expression		 ISO Monocrotophos affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein
Monocrotophos results in increased expression of AHR mRNA		 CTD PMID:22733800 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases expression		 ISO Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]
Monocrotophos results in decreased expression of AIFM1 protein		 CTD PMID:33078895 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions
increases expression		 ISO Monocrotophos results in increased expression of and affects the localization of APEX1 protein
Monocrotophos results in increased expression of APEX1 mRNA		 CTD PMID:28887667 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP Monocrotophos results in increased expression of and affects the localization of BAX protein; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]
Monocrotophos results in increased expression of BAX mRNA; Monocrotophos results in increased expression of BAX protein		 CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP Monocrotophos results in increased expression of BBC3 mRNA CTD PMID:20957986 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Monocrotophos results in decreased activity of BCHE protein CTD PMID:19730754 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions		 EXP Monocrotophos results in increased expression of BCL2 mRNA; Monocrotophos results in increased expression of BCL2 protein
Monocrotophos results in decreased expression of BCL2 mRNA; Monocrotophos results in decreased expression of BCL2 protein
resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein]		 CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Monocrotophos results in decreased expression of BCL2L2 mRNA; Monocrotophos results in decreased expression of BCL2L2 protein CTD PMID:20957986 PMID:21445290 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP Monocrotophos results in increased expression of CASP3 mRNA; Monocrotophos results in increased expression of CASP3 protein; Monocrotophos results in increased expression of CASP3 protein modified form
resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 protein]		 CTD PMID:20957986 PMID:21445290 PMID:23833438 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression EXP Monocrotophos results in increased expression of CASP9 mRNA; Monocrotophos results in increased expression of CASP9 protein; Monocrotophos results in increased expression of CASP9 protein modified form CTD PMID:20957986 PMID:21445290 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity EXP Monocrotophos results in decreased activity of CAT protein CTD PMID:22751200 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Monocrotophos results in increased expression of CDKN1A mRNA; Monocrotophos results in increased expression of CDKN1A protein CTD PMID:20957986 PMID:21445290 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of COX4I1 mRNA] CTD PMID:35403558 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Monocrotophos results in increased expression of and affects the localization of CYCS protein CTD PMID:20957986 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
multiple interactions		 EXP
ISO		 Monocrotophos results in increased expression of CYP1A1 protein
Monocrotophos results in increased activity of CYP1A1 protein
Monocrotophos results in increased expression of CYP1A1 mRNA; Monocrotophos results in increased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein		 CTD PMID:21445290 PMID:22733800 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Monocrotophos results in increased expression of CYP1A2 protein CTD PMID:21445290 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Monocrotophos results in increased expression of CYP2B2 protein CTD PMID:21445290 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
multiple interactions
increases expression		 ISO Monocrotophos results in increased activity of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein
Monocrotophos results in increased expression of CYP2B6 mRNA; Monocrotophos results in increased expression of CYP2B6 protein		 CTD PMID:22733800 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
increases activity
multiple interactions		 EXP
ISO		 Monocrotophos results in increased expression of CYP2E1 protein
Monocrotophos results in increased activity of CYP2E1 protein
Monocrotophos results in increased expression of CYP2E1 mRNA; Monocrotophos results in increased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein		 CTD PMID:21445290 PMID:22733800 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions		 ISO Monocrotophos results in increased activity of CYP3A4 protein
Monocrotophos results in increased expression of CYP3A4 mRNA; Monocrotophos results in increased expression of CYP3A4 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein		 CTD PMID:22733800 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP Monocrotophos results in increased expression of CYP7A1 mRNA CTD PMID:32267039 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fasn fatty acid synthase increases activity
increases expression		 EXP Monocrotophos results in increased activity of FASN protein
Monocrotophos results in increased expression of FASN mRNA		 CTD PMID:32267039 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Monocrotophos results in increased expression of FOS protein CTD PMID:20957986 PMID:21445290 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects activity
multiple interactions
increases activity		 EXP Monocrotophos affects the activity of G6PD protein
[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein
Monocrotophos results in increased activity of G6PD protein		 CTD PMID:24248738 PMID:32267039 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gck glucokinase increases activity EXP Monocrotophos results in increased activity of GCK protein CTD PMID:32267039 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
affects activity
multiple interactions		 EXP Monocrotophos results in decreased activity of GSR protein
Monocrotophos affects the activity of GSR protein
[Monocrotophos co-treated with quinalphos] affects the activity of GSR protein		 CTD PMID:22751200 PMID:24248738 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 EXP
ISO		 Monocrotophos results in increased expression of GSTP1 mRNA; Monocrotophos results in increased expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein		 CTD PMID:21445290 PMID:22733800 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP Monocrotophos results in increased expression of HMGCR mRNA CTD PMID:32267039 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Monocrotophos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP
ISO		 Monocrotophos results in increased expression of JUN protein
Monocrotophos results in increased expression of and results in increased phosphorylation of JUN protein		 CTD PMID:20957986 PMID:21445290 PMID:28887667 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression EXP Monocrotophos results in increased expression of LDLR mRNA CTD PMID:32267039 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lig3 DNA ligase 3 increases expression ISO Monocrotophos results in increased expression of LIG3 mRNA CTD PMID:28887667 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lpin1 lipin 1 increases activity EXP Monocrotophos results in increased activity of LPIN1 protein CTD PMID:32267039 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Monocrotophos results in increased expression of LPL mRNA CTD PMID:32267039 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP Monocrotophos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases activity EXP Monocrotophos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Monocrotophos results in decreased expression of MCL1 mRNA; Monocrotophos results in decreased expression of MCL1 protein CTD PMID:20957986 PMID:21445290 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND1 mRNA] CTD PMID:35403558 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 decreases expression
multiple interactions		 EXP Monocrotophos results in decreased expression of ND2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND2 mRNA]		 CTD PMID:35403558 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Nes nestin decreases expression
increases expression		 ISO Monocrotophos results in decreased expression of NES mRNA
Monocrotophos results in increased expression of NES protein		 CTD PMID:33569802 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Monocrotophos results in increased expression of NFE2L2 protein
Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]
Monocrotophos results in decreased expression of NFE2L2 mRNA		 CTD PMID:28887667 PMID:33078895 PMID:35403558 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression
multiple interactions		 ISO Monocrotophos affects the expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein		 CTD PMID:22733800 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases expression
increases expression		 ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
Monocrotophos results in decreased expression of NR1I3 protein
Monocrotophos results in increased expression of NR1I3 mRNA; Monocrotophos results in increased expression of NR1I3 protein		 CTD PMID:22733800 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of NRF1 mRNA] CTD PMID:35403558 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO Monocrotophos results in decreased expression of OGG1 mRNA CTD PMID:28887667 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Monocrotophos results in increased expression of PARP1 mRNA; Monocrotophos results in increased expression of PARP1 protein CTD PMID:28887667 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Monocrotophos results in decreased expression of PPARA mRNA CTD PMID:32267039 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Monocrotophos results in increased expression of PPARG mRNA CTD PMID:32267039 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP Monocrotophos results in decreased expression of PPARGC1A mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of PPARGC1A mRNA]		 CTD PMID:35403558 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression EXP Monocrotophos results in increased expression of SCARB1 mRNA CTD PMID:32267039 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions		 EXP Monocrotophos results in decreased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of SOD2 mRNA]		 CTD PMID:35403558 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Monocrotophos results in increased expression of SREBF1 mRNA CTD PMID:32267039 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP Monocrotophos results in increased expression of SREBF2 mRNA CTD PMID:32267039 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO [perfluorooctanoic acid co-treated with Monocrotophos] results in decreased expression of TAC1 mRNA CTD PMID:33569802 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of TFAM mRNA] CTD PMID:35403558 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity		 EXP Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP Monocrotophos results in increased expression of TNF protein CTD PMID:32267039 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Monocrotophos results in increased expression of TP53 mRNA; Monocrotophos results in increased expression of TP53 protein; Monocrotophos results in increased expression of TRP53 mRNA; Monocrotophos results in increased expression of TRP53 protein CTD PMID:20957986 PMID:21445290 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        agrochemical 16894
          monocrotophos 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              oxoacid 18808
                                pnictogen oxoacid 14987
                                  phosphorus oxoacid 14587
                                    phosphoric acids 13935
                                      phosphoric acid 13935
                                        phosphoric acid derivative 13817
                                          phosphate 13843
                                            organic phosphate 13816
                                              alkyl phosphate 7977
                                                dialkyl phosphate 7512
                                                  monocrotophos 62
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