pediculicide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pediculicide	go back to main search page
Accession:	CHEBI:38706	browse the term
Definition:	Substance used to treat lice (genus Pediculus) infestation.
Synonyms:	related_synonym:	pediculicides

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Rat (750) Mouse (740) Human (829) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (17) Green Monkey (0) Naked Mole-rat (0) All
Genes (750)

gamma-hexachlorocyclohexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

Hexachlorocyclohexane results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Hexachlorocyclohexane results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 3

increases expression

Hexachlorocyclohexane results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

increases expression

Hexachlorocyclohexane results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

increases expression

Hexachlorocyclohexane results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases methylation

Hexachlorocyclohexane results in increased methylation of ABL1 promoter

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetylcholinesterase

multiple interactions
decreases activity
increases activity
affects activity

Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
Hexachlorocyclohexane results in decreased activity of ACHE protein
Hexachlorocyclohexane results in increased activity of ACHE protein
Hexachlorocyclohexane affects the activity of ACHE protein

PMID:6186625 PMID:19893075 PMID:20663516

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

decreases expression
affects activity

Hexachlorocyclohexane results in decreased expression of ACLY mRNA
Hexachlorocyclohexane affects the activity of ACLY protein

PMID:7535533 PMID:17785943

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aconitase 2

increases expression

Hexachlorocyclohexane results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA synthetase long-chain family member 5

decreases expression

Hexachlorocyclohexane results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

actin, beta

affects expression

Hexachlorocyclohexane affects the expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

activin A receptor type 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

activin A receptor type 1C

increases expression

Hexachlorocyclohexane results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

adducin 3

affects expression

Hexachlorocyclohexane affects the expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

aryl hydrocarbon receptor

increases expression

Hexachlorocyclohexane results in increased expression of AHR mRNA

PMID:17785943 PMID:25572523

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 4

decreases expression

Hexachlorocyclohexane results in decreased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 7 member A3

increases expression

Hexachlorocyclohexane results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

AKT serine/threonine kinase 1

decreases phosphorylation

Hexachlorocyclohexane results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 8 family, member A1

increases expression

Hexachlorocyclohexane results in increased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

ALK receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression
increases activity

[Hexachlorocyclohexane co-treated with isoproturon] results in decreased activity of ALPL protein; [Hexachlorocyclohexane co-treated with isoproturon] results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased activity of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

apolipoprotein B

affects expression

Hexachlorocyclohexane affects the expression of APOB mRNA

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

androgen receptor

affects binding
multiple interactions

Hexachlorocyclohexane binds to AR protein
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]

PMID:14565775 PMID:21295777 PMID:26022396

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

armadillo repeat containing 6

decreases expression

Hexachlorocyclohexane results in decreased expression of ARMC6 mRNA

NCBI chr16:19,191,106...19,201,528
Ensembl chr16:19,191,093...19,206,047

G

aryl hydrocarbon receptor nuclear translocator

increases expression

Hexachlorocyclohexane results in increased expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arylsulfatase A

decreases activity

Hexachlorocyclohexane results in decreased activity of ARSA protein

NCBI chr 7:120,542,788...120,547,577
Ensembl chr 7:120,543,362...120,548,783

G

agouti signaling protein

increases response to substance

A mutant form results in increased susceptibility to Hexachlorocyclohexane

NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Hexachlorocyclohexane results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

ATP synthase F1 subunit delta

decreases expression

Hexachlorocyclohexane results in decreased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase inhibitory factor subunit 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of BAX mRNA; Hexachlorocyclohexane results in increased expression of BAX protein
Hexachlorocyclohexane results in decreased expression of BAX protein
Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]

PMID:14688026 PMID:18174961 PMID:19041923

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions
decreases activity

Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Hexachlorocyclohexane results in decreased activity of BCHE protein

PMID:20455324 PMID:20663516

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of BCL2 protein
Hexachlorocyclohexane results in increased expression of BCL2 mRNA; Hexachlorocyclohexane results in increased expression of BCL2 protein
[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]

PMID:14688026 PMID:18174961 PMID:19041923

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of BCL2L1 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]

PMID:19041923 PMID:22001173

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BCL6, transcription repressor

increases expression

Hexachlorocyclohexane results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

increases expression

Hexachlorocyclohexane results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

affects expression
multiple interactions

Hexachlorocyclohexane affects the expression of BECN1 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

basic helix-loop-helix family, member a15

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA

NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713

G

basic helix-loop-helix family, member e40

decreases expression

Hexachlorocyclohexane results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 3

increases expression

Hexachlorocyclohexane results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

similar to human chromosome 15 open reading frame 39

decreases expression

Hexachlorocyclohexane results in decreased expression of C15ORF39 mRNA

NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941

G

calreticulin

decreases expression

Hexachlorocyclohexane results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

cysteinyl-tRNA synthetase 1

increases expression

Hexachlorocyclohexane results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 3

increases expression
increases activity
multiple interactions
decreases activity

Hexachlorocyclohexane results in increased expression of CASP3 mRNA; Hexachlorocyclohexane results in increased expression of CASP3 protein
Hexachlorocyclohexane results in increased activity of CASP3 protein
[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP3 protein; Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]
Hexachlorocyclohexane results in decreased activity of CASP3 protein

PMID:19038305 PMID:19041923 PMID:19221147 PMID:19815060 PMID:20036686 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression
multiple interactions
increases activity
decreases activity

Hexachlorocyclohexane results in increased expression of CASP9 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]
Hexachlorocyclohexane results in decreased activity of CASP9 protein

PMID:19038305 PMID:19041923 PMID:22001173

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

increases expression

Hexachlorocyclohexane results in increased expression of CAST mRNA

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

multiple interactions
increases activity
decreases activity

Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]
Hexachlorocyclohexane results in increased activity of CAT protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]

PMID:1708174 PMID:2429406 PMID:2469257 PMID:9057899 PMID:9467884 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin G2

increases expression

Hexachlorocyclohexane results in increased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

Cd47 molecule

decreases expression

Hexachlorocyclohexane results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

Cd69 molecule

increases expression

Hexachlorocyclohexane results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

CD84 molecule

increases expression

Hexachlorocyclohexane results in increased expression of CD84 mRNA

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

G

cell division cycle 42

decreases expression

Hexachlorocyclohexane results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

affects activity

Hexachlorocyclohexane affects the activity of CDIPT protein

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

G

cyclin-dependent kinase inhibitor 1A

increases expression
decreases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of CDKN1A mRNA; Hexachlorocyclohexane results in increased expression of CDKN1A protein
Hexachlorocyclohexane results in decreased expression of CDKN1A protein
Hexachlorocyclohexane affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased expression of CDKN1A protein]

PMID:14688026 PMID:17785943 PMID:18174961

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein beta

increases expression

Hexachlorocyclohexane results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

carboxylesterase 2H

increases expression

Hexachlorocyclohexane results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Hexachlorocyclohexane results in increased expression of CHAC1 mRNA

PMID:23824090 PMID:24356939

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

cell death-inducing DFFA-like effector a

decreases expression

Hexachlorocyclohexane results in decreased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytokine inducible SH2-containing protein

decreases expression

Hexachlorocyclohexane results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

Hexachlorocyclohexane results in increased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

chloride voltage-gated channel 5

decreases expression

Hexachlorocyclohexane results in decreased expression of CLCN5 mRNA

NCBI chr X:15,185,380...15,339,977
Ensembl chr X:15,185,451...15,334,264

G

clusterin

increases expression

Hexachlorocyclohexane results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cyclic nucleotide gated channel subunit alpha 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CNGA1 mRNA

NCBI chr14:35,566,947...35,605,065
Ensembl chr14:35,567,125...35,605,065

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases activity

Hexachlorocyclohexane results in decreased activity of CNP protein

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

carboxypeptidase D

increases expression

Hexachlorocyclohexane results in increased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

cysteine rich transmembrane BMP regulator 1

increases expression

Hexachlorocyclohexane results in increased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

cystatin 8

affects expression

Hexachlorocyclohexane affects the expression of CST8 mRNA

NCBI chr 3:136,244,586...136,255,412
Ensembl chr 3:136,244,636...136,251,273

G

C-X3-C motif chemokine receptor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

cytochrome c, somatic

affects expression

Hexachlorocyclohexane affects the expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of CYP11A1 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]

PMID:15749814 PMID:17080404

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity
decreases activity

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
Hexachlorocyclohexane results in increased expression of CYP19A1 mRNA
Hexachlorocyclohexane results in increased activity of CYP19A1 protein
Hexachlorocyclohexane results in decreased activity of CYP19A1 protein

PMID:12849724 PMID:17080404

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions

Hexachlorocyclohexane results in increased activity of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of CYP1A1 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]
Hexachlorocyclohexane inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

PMID:11684361 PMID:12842176 PMID:15620088 PMID:16641539 PMID:17919674 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
increases expression
multiple interactions

Hexachlorocyclohexane results in increased activity of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of CYP1A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]

PMID:12842176 PMID:16641539 PMID:17919674 PMID:17984293 PMID:18486174 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases activity

Hexachlorocyclohexane results in increased activity of CYP2A1 protein

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression
multiple interactions
increases activity

Hexachlorocyclohexane results in increased expression of CYP2B1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]
Hexachlorocyclohexane results in increased activity of CYP2B1 protein

PMID:11684361 PMID:12842176 PMID:17919674 PMID:17984293 PMID:18486174 More...

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions
increases activity

Hexachlorocyclohexane results in increased expression of CYP2B2 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]
Hexachlorocyclohexane results in increased activity of CYP2B2 protein

PMID:11684361 PMID:12842176 PMID:17785943 PMID:17919674 PMID:17984293 More...

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Hexachlorocyclohexane results in increased expression of CYP2B6 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B6 protein

PMID:15548381 PMID:20035023

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

increases expression

Hexachlorocyclohexane results in increased expression of CYP2C11 mRNA; Hexachlorocyclohexane results in increased expression of CYP2C11 protein

PMID:11684361 PMID:16837770

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 12

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

Hexachlorocyclohexane results in increased expression of CYP2D1 mRNA

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases activity
increases expression
decreases response to substance
decreases expression

Hexachlorocyclohexane results in increased activity of CYP2E1 protein
Hexachlorocyclohexane results in increased expression of CYP2E1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Hexachlorocyclohexane
Hexachlorocyclohexane results in decreased expression of CYP2E1 mRNA

PMID:12842176 PMID:14631868 PMID:17919674 PMID:17984293 PMID:20035023 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases activity

Hexachlorocyclohexane results in increased expression of CYP3A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP3A2 protein
Hexachlorocyclohexane results in increased expression of CYP3A4 protein
Hexachlorocyclohexane results in increased activity of CYP3A2 protein

PMID:3569844 PMID:11684361 PMID:15548381 PMID:16837770

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
affects expression

Hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA
Hexachlorocyclohexane affects the expression of CYP3A23-3A1 mRNA

PMID:14613717 PMID:22001173 PMID:25572523

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 51

increases expression

Hexachlorocyclohexane results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

death associated protein 3

increases expression

Hexachlorocyclohexane results in increased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

decorin

decreases expression

Hexachlorocyclohexane results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Hexachlorocyclohexane results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member C5

decreases expression

Hexachlorocyclohexane results in decreased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

dopamine receptor D2

increases expression

Hexachlorocyclohexane results in increased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

increases expression

Hexachlorocyclohexane results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

eukaryotic translation elongation factor 1 alpha 1

affects expression

Hexachlorocyclohexane affects the expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

early growth response 1

increases expression

Hexachlorocyclohexane results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2B subunit gamma

affects expression

Hexachlorocyclohexane affects the expression of EIF2B3 mRNA

NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332

G

eukaryotic translation initiation factor 2B subunit delta

affects expression

Hexachlorocyclohexane affects the expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 5

increases expression

Hexachlorocyclohexane results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

Eph receptor A3

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA

NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900

G

Eph receptor A8

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

estrogen receptor 1

multiple interactions
increases activity
affects binding
decreases expression

[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
Hexachlorocyclohexane results in increased activity of ESR1 protein
Hexachlorocyclohexane binds to ESR1 protein
Hexachlorocyclohexane results in decreased expression of ESR1 protein
Hexachlorocyclohexane binds to and results in increased activity of ESR1 protein

PMID:14579009 PMID:15253041 PMID:16329587 PMID:20209442 PMID:21278053 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

Hexachlorocyclohexane results in increased activity of ESR2 protein

PMID:15064155 PMID:26139245

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

increases expression

Hexachlorocyclohexane results in increased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ecotropic viral integration site 2A

increases expression

Hexachlorocyclohexane results in increased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

family with sequence similarity 107, member B

increases expression

Hexachlorocyclohexane results in increased expression of FAM107B mRNA

NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989

G

Fas cell surface death receptor

increases expression

Hexachlorocyclohexane results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Hexachlorocyclohexane results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

affects activity

Hexachlorocyclohexane affects the activity of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

F-box protein 32

increases expression

Hexachlorocyclohexane results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

FKBP prolyl isomerase 3

affects expression

Hexachlorocyclohexane affects the expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

fibronectin 1

affects expression

Hexachlorocyclohexane affects the expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Hexachlorocyclohexane results in increased expression of FOS mRNA
alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
Hexachlorocyclohexane results in increased expression of FOS mRNA; Hexachlorocyclohexane results in increased expression of FOS protein
W 7 inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]

PMID:1380685 PMID:1710164 PMID:7531829 PMID:7534335 PMID:10072926

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A1

decreases expression

Hexachlorocyclohexane results in decreased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

FRAT regulator of WNT signaling pathway 1

increases expression

Hexachlorocyclohexane results in increased expression of FRAT1 mRNA

NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945

G

follicle stimulating hormone subunit beta

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphate dehydrogenase

affects activity
increases activity

Hexachlorocyclohexane affects the activity of G6PD protein
Hexachlorocyclohexane results in increased activity of G6PD protein

PMID:2461408 PMID:7535533 PMID:8519523

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

decreases expression

Hexachlorocyclohexane results in decreased expression of GABARAPL2 mRNA

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
increases expression

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Hexachlorocyclohexane results in increased expression of GABRA1 mRNA

PMID:9316872 PMID:11156579 PMID:14637376 PMID:25572523

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944

G

gamma-aminobutyric acid type A receptor subunit alpha6

multiple interactions

Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

gamma-aminobutyric acid type A receptor subunit beta1

affects binding
multiple interactions

Hexachlorocyclohexane binds to GABRB1 protein
Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]

PMID:11156579 PMID:11489356

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit beta 3

affects binding
multiple interactions

Hexachlorocyclohexane binds to GABRB3 protein
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:9316872 PMID:11312652 PMID:11489356 PMID:16537435

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:9316872 PMID:11156579 PMID:14637376

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

gamma-aminobutyric acid type A receptor subunit rho 1

affects binding

Hexachlorocyclohexane binds to GABRR1 protein

NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228

G

GATA binding protein 3

increases expression

Hexachlorocyclohexane results in increased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucokinase

increases expression

Hexachlorocyclohexane results in increased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Hexachlorocyclohexane results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Hexachlorocyclohexane results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GDNF family receptor alpha 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

G

gamma-glutamyltransferase 1

multiple interactions
affects activity
decreases activity
increases activity

Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in increased activity of GGT1 protein]
Hexachlorocyclohexane affects the activity of GGT1 protein
Hexachlorocyclohexane results in decreased activity of GGT1 protein

PMID:8519523 PMID:9475050 PMID:11349524

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

affects localization
increases expression
decreases phosphorylation
decreases expression
increases degradation
increases phosphorylation
multiple interactions

Hexachlorocyclohexane affects the localization of GJA1 protein
Hexachlorocyclohexane results in increased expression of GJA1 protein
Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein
Hexachlorocyclohexane results in decreased expression of GJA1 mRNA; Hexachlorocyclohexane results in decreased expression of GJA1 protein
Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form
Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]; Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane affects the localization of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]

PMID:7530866 PMID:8824497 PMID:11532877 PMID:12807735 PMID:15194225 More...

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycine receptor, alpha 1

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA1 protein

NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162

G

glycine receptor, alpha 2

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA2 protein

NCBI chr X:29,020,377...29,241,666
Ensembl chr X:29,020,557...29,241,666

G

glycine receptor, alpha 3

decreases activity

Hexachlorocyclohexane results in decreased activity of GLRA3 protein

NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753

G

glutamate-ammonia ligase

decreases expression

Hexachlorocyclohexane results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glycine-N-acyltransferase

affects expression

Hexachlorocyclohexane affects the expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

G protein subunit alpha 12

affects expression

Hexachlorocyclohexane affects the expression of GNA12 mRNA

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

gonadotropin releasing hormone 1

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glutamic-oxaloacetic transaminase 1

increases expression

Hexachlorocyclohexane results in increased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycerol-3-phosphate acyltransferase 3

increases expression

Hexachlorocyclohexane results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

G protein-coupled receptor 18

increases expression

Hexachlorocyclohexane results in increased expression of GPR18 mRNA

PMID:23824090 PMID:24356939

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

[Hexachlorocyclohexane co-treated with isoproturon] results in increased activity of GPT protein
Hexachlorocyclohexane results in increased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamic--pyruvic transaminase 2

increases expression

Hexachlorocyclohexane results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione-disulfide reductase

multiple interactions
increases expression
decreases activity
increases activity

[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Permethrin] results in decreased activity of GSR protein; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]
Hexachlorocyclohexane results in increased expression of GSR mRNA
Hexachlorocyclohexane results in increased activity of GSR protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in increased activity of GSR protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]

PMID:1716606 PMID:9704597 PMID:10817630 PMID:11349524 PMID:11404799 More...

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

affects expression

Hexachlorocyclohexane affects the expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 5

increases expression

Hexachlorocyclohexane results in increased expression of GSTA5 mRNA

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glucuronidase, beta

affects activity

Hexachlorocyclohexane affects the activity of GUSB protein

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hemoglobin, epsilon 2

decreases expression

Hexachlorocyclohexane results in decreased expression of HBG2 protein

NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hepatocyte nuclear factor 4, alpha

affects expression

Hexachlorocyclohexane affects the expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

4-hydroxyphenylpyruvate dioxygenase

increases expression

Hexachlorocyclohexane results in increased expression of HPD mRNA

NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Hexachlorocyclohexane results in decreased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases activity

Hexachlorocyclohexane results in decreased activity of HSD17B1 protein

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases activity

Hexachlorocyclohexane results in decreased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases expression
multiple interactions

Hexachlorocyclohexane results in decreased expression of HSD3B2 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 1A

affects localization

Hexachlorocyclohexane affects the localization of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 4

increases expression

Hexachlorocyclohexane results in increased expression of HSPA4 protein

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

5-hydroxytryptamine receptor 2A

increases expression

Hexachlorocyclohexane results in increased expression of HTR2A mRNA

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

HYLS1, centriolar and ciliogenesis associated

decreases expression

Hexachlorocyclohexane results in decreased expression of HYLS1 mRNA

NCBI chr 8:33,912,692...33,921,760
Ensembl chr 8:33,912,692...33,921,760

G

inhibitor of DNA binding 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NADP(+)) 1

affects expression

Hexachlorocyclohexane affects the expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

immediate early response 3

increases expression

Hexachlorocyclohexane results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon gamma

decreases expression

Hexachlorocyclohexane results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 alpha

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]
Hexachlorocyclohexane results in increased expression of IL1A mRNA; Hexachlorocyclohexane results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 5

decreases expression

Hexachlorocyclohexane results in decreased expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

insulin receptor substrate 1

decreases phosphorylation

Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

ISL LIM homeobox 2

increases expression

Hexachlorocyclohexane results in increased expression of ISL2 mRNA

NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation
multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of JUN protein
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of JUN protein

PMID:15888667 PMID:23927878

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 21B

increases expression

Hexachlorocyclohexane results in increased expression of KIF21B mRNA

NCBI chr13:47,576,129...47,626,112
Ensembl chr13:47,576,160...47,626,127

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KLF transcription factor 9

increases expression

Hexachlorocyclohexane results in increased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch-like family member 24

increases expression

Hexachlorocyclohexane results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lactate dehydrogenase A

decreases expression

Hexachlorocyclohexane results in decreased expression of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

decreases expression

Hexachlorocyclohexane results in decreased expression of LDHB protein

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

leptin

affects expression

Hexachlorocyclohexane affects the expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

Hexachlorocyclohexane results in decreased expression of LHCGR protein

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

LIF, interleukin 6 family cytokine

increases expression

Hexachlorocyclohexane results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

leucine rich repeat containing 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

lymphatic vessel endothelial hyaluronan receptor 1

increases expression

Hexachlorocyclohexane results in increased expression of XLKD1 mRNA

NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Hexachlorocyclohexane results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

multiple interactions

Hexachlorocyclohexane promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

Hexachlorocyclohexane results in decreased expression of MAP4K4 mRNA

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein

PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myelin basic protein

decreases expression
affects expression

Hexachlorocyclohexane results in decreased expression of MBP protein
Hexachlorocyclohexane affects the expression of MBP mRNA

PMID:1701514 PMID:22954530

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

membrane-bound transcription factor peptidase, site 2

increases expression

Hexachlorocyclohexane results in increased expression of MBTPS2 mRNA

NCBI chr X:37,410,914...37,461,130
Ensembl chr X:37,410,811...37,464,430

G

mesenchyme homeobox 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MEOX2 mRNA

NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467

G

MER proto-oncogene, tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

myeloperoxidase

multiple interactions
increases activity

[Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein
Hexachlorocyclohexane results in increased activity of MPO protein

PMID:7503757 PMID:11141352

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

metallothionein 1

increases expression

Hexachlorocyclohexane results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

mitochondrial carrier 2

decreases expression

Hexachlorocyclohexane results in decreased expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

Hexachlorocyclohexane results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Hexachlorocyclohexane results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 3

affects expression

Hexachlorocyclohexane affects the expression of MYH3 mRNA

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

nanos C2HC-type zinc finger 1

decreases expression

Hexachlorocyclohexane results in decreased expression of NANOS1 mRNA

NCBI chr 1:259,897,663...259,901,561
Ensembl chr 1:259,897,939...259,898,730

G

nuclear receptor coactivator 7

increases expression

Hexachlorocyclohexane results in increased expression of NCOA7 mRNA

NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871

G

NFE2 like bZIP transcription factor 2

decreases expression

Hexachlorocyclohexane results in decreased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFE2 like bZIP transcription factor 3

decreases expression

Hexachlorocyclohexane results in decreased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nuclear factor I/A

decreases expression

Hexachlorocyclohexane results in decreased expression of NFIA mRNA

NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885

G

nuclear factor I/B

decreases expression

Hexachlorocyclohexane results in decreased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nuclear factor I X

increases expression

Hexachlorocyclohexane results in increased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

multiple interactions
increases phosphorylation
increases activity

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]
Hexachlorocyclohexane results in increased phosphorylation of NFKB1 protein

PMID:15019085 PMID:15025948

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

increases phosphorylation

Hexachlorocyclohexane results in increased phosphorylation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NIPBL, cohesin loading factor

increases expression

Hexachlorocyclohexane results in increased expression of NIPBL mRNA

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

G

NOP58 ribonucleoprotein

increases expression

Hexachlorocyclohexane results in increased expression of NOL5 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

nitric oxide synthase 2

increases expression

Hexachlorocyclohexane results in increased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Hexachlorocyclohexane results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression
increases activity

Hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
Hexachlorocyclohexane results in increased expression of NR1I2 mRNA
Hexachlorocyclohexane results in increased activity of NR1I2 protein

PMID:14613717 PMID:15548381 PMID:16054614 PMID:25572523 PMID:25680588

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity

Hexachlorocyclohexane results in increased expression of NR1I3 mRNA
Hexachlorocyclohexane results in increased activity of NR1I3 protein

PMID:25572523 PMID:28927721

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 6

affects expression

Hexachlorocyclohexane affects the expression of NR2F6 mRNA

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

increases expression

Hexachlorocyclohexane results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

increases expression

Hexachlorocyclohexane results in increased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear respiratory factor 1

increases expression

Hexachlorocyclohexane results in increased expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

ornithine decarboxylase 1

multiple interactions
increases activity
increases expression

Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases expression

Hexachlorocyclohexane results in increased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

one cut homeobox 1

decreases expression

Hexachlorocyclohexane results in decreased expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

orthodenticle homeobox 2

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

Hexachlorocyclohexane results in decreased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

Parkinsonism associated deglycase

decreases activity

Hexachlorocyclohexane results in decreased activity of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

paired box 6

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

programmed cell death 4

increases expression

Hexachlorocyclohexane results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

platelet derived growth factor receptor beta

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

PDZ and LIM domain 1

decreases expression

Hexachlorocyclohexane results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

pellino E3 ubiquitin protein ligase 1

increases expression

Hexachlorocyclohexane results in increased expression of PELI1 mRNA

NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285

G

period circadian regulator 2

decreases expression

Hexachlorocyclohexane results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

phosphogluconate dehydrogenase

affects activity

Hexachlorocyclohexane affects the activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

progesterone receptor

affects binding
multiple interactions

Hexachlorocyclohexane binds to PGR protein
[Progesterone co-treated with Hexachlorocyclohexane] results in decreased expression of PGR mRNA; Hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Hexachlorocyclohexane inhibits the reaction [Progesterone binds to PGR protein]

PMID:9144411 PMID:14579009 PMID:26022396

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

polymeric immunoglobulin receptor

increases expression

Hexachlorocyclohexane results in increased expression of PIGR mRNA

NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875

G

praja ring finger ubiquitin ligase 2

increases expression

Hexachlorocyclohexane results in increased expression of PJA2 mRNA

NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783

G

phospholipase A and acyltransferase 5

decreases expression

Hexachlorocyclohexane results in decreased expression of PLAAT5 mRNA

NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184

G

phospholipase C-like 1

increases expression

Hexachlorocyclohexane results in increased expression of PLCL1 mRNA

NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782

G

phospholipid phosphatase 3

increases expression

Hexachlorocyclohexane results in increased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

plexin D1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

proline-rich nuclear receptor coactivator 1

increases expression

Hexachlorocyclohexane results in increased expression of PNRC1 mRNA

NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161

G

DNA polymerase gamma 2, accessory subunit

increases expression

Hexachlorocyclohexane results in increased expression of POLG2 mRNA

NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008

G

proopiomelanocortin

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

cytochrome p450 oxidoreductase

increases expression

Hexachlorocyclohexane results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

PPARG coactivator 1 alpha

increases expression

Hexachlorocyclohexane results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

Hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

PPARG related coactivator 1

increases expression

Hexachlorocyclohexane results in increased expression of PPRC1 mRNA

NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587

G

protein kinase cAMP-activated catalytic subunit beta

affects expression

Hexachlorocyclohexane affects the expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase C, eta

affects expression

Hexachlorocyclohexane affects the expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

peroxiredoxin like 2B

decreases expression

Hexachlorocyclohexane results in decreased expression of PRXL2B mRNA

NCBI chr 5:165,462,610...165,465,213

G

proteasome 20S subunit beta 3

decreases expression

Hexachlorocyclohexane results in decreased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Hexachlorocyclohexane results in increased expression of and results in increased activity of PTGS2 protein
Hexachlorocyclohexane results in increased expression of PTGS2 mRNA; Hexachlorocyclohexane results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase 4A1

increases expression

Hexachlorocyclohexane results in increased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

RAB14, member RAS oncogene family

increases expression

Hexachlorocyclohexane results in increased expression of RAB14 mRNA

NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172

G

RAB34, member RAS oncogene family

affects expression

Hexachlorocyclohexane affects the expression of RAB34 mRNA

NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

Hexachlorocyclohexane results in decreased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS like proto-oncogene A

increases expression

Hexachlorocyclohexane results in increased expression of RALA mRNA

NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063

G

Ral GTPase activating protein catalytic subunit alpha 1

increases expression

Hexachlorocyclohexane results in increased expression of RALGAPA1 mRNA

NCBI chr 6:72,977,432...73,252,378
Ensembl chr 6:72,977,432...73,252,378

G

retinoic acid receptor, alpha

increases activity

Hexachlorocyclohexane results in increased activity of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RB transcriptional corepressor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 10

decreases expression

Hexachlorocyclohexane results in decreased expression of RBM10 mRNA

NCBI chr X:1,540,399...1,572,571
Ensembl chr X:1,540,398...1,572,575

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
increases phosphorylation
affects localization

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein]
Hexachlorocyclohexane results in increased phosphorylation of RELA protein
Hexachlorocyclohexane affects the localization of RELA protein

PMID:15019085 PMID:15025948 PMID:19038305

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ret proto-oncogene

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

regulator of G-protein signaling 2

decreases expression

Hexachlorocyclohexane results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

arginyl aminopeptidase

decreases expression

Hexachlorocyclohexane results in decreased expression of RNPEP mRNA

NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998

G

ribosomal protein S15

decreases expression

Hexachlorocyclohexane results in decreased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

radical S-adenosyl methionine domain containing 2

decreases expression

Hexachlorocyclohexane results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

retinoid X receptor alpha

affects expression

Hexachlorocyclohexane affects the expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor beta

increases activity

Hexachlorocyclohexane results in increased activity of RXRB protein

NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773

G

retinoid X receptor gamma

decreases expression

Hexachlorocyclohexane results in decreased expression of RXRG mRNA

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

stearoyl-CoA desaturase

decreases expression

Hexachlorocyclohexane results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

syndecan 4

increases expression

Hexachlorocyclohexane results in increased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

SEC22 homolog A, vesicle trafficking protein

decreases expression

Hexachlorocyclohexane results in decreased expression of SEC22A mRNA

NCBI chr11:65,402,583...65,462,329
Ensembl chr11:65,402,684...65,462,319

G

SEC31 homolog A, COPII coat complex component

increases expression

Hexachlorocyclohexane results in increased expression of SEC31A mRNA

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

semaphorin 3G

decreases expression

Hexachlorocyclohexane results in decreased expression of SEMA3G mRNA

NCBI chr16:6,413,589...6,425,221
Ensembl chr16:6,413,589...6,425,221

G

serine incorporator 3

affects expression

Hexachlorocyclohexane affects the expression of SERINC3 mRNA

NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808

G

serpin family E member 2

decreases expression

Hexachlorocyclohexane results in decreased expression of SERPINE2 mRNA

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

sestrin 2

increases expression

Hexachlorocyclohexane results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

serum/glucocorticoid regulated kinase 1

decreases expression
increases expression

Hexachlorocyclohexane results in decreased expression of SGK1 mRNA
Hexachlorocyclohexane results in increased expression of SGK1 mRNA

PMID:17785943 PMID:24356939

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sex hormone binding globulin

multiple interactions
decreases expression

Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
Hexachlorocyclohexane results in decreased expression of SHBG protein

PMID:9171990 PMID:18248869

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

sucrase-isomaltase

decreases activity

Hexachlorocyclohexane results in decreased activity of SI protein

NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260

G

solute carrier family 10 member 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 11 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 22 member 1

decreases activity

Hexachlorocyclohexane results in decreased activity of SLC22A1 protein

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22, member 25

affects expression

Hexachlorocyclohexane affects the expression of SLC22A9 mRNA

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 25, member 30

decreases expression

Hexachlorocyclohexane results in decreased expression of SLC25A30 mRNA

NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613

G

solute carrier family 3 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 4 member 4

increases expression

Hexachlorocyclohexane results in increased expression of SLC4A4 mRNA

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 7 member 11

increases expression

Hexachlorocyclohexane results in increased expression of SLC7A11 mRNA

PMID:24356939 PMID:26198647

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 2

increases expression

Hexachlorocyclohexane results in increased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

snail family transcriptional repressor 2

affects expression

Hexachlorocyclohexane affects the expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

small nuclear ribonucleoprotein U1 subunit 70

increases expression

Hexachlorocyclohexane results in increased expression of SNRNP70 mRNA

NCBI chr 1:95,856,038...95,876,434
Ensembl chr 1:95,856,036...95,876,392

G

suppressor of cytokine signaling 2

decreases expression

Hexachlorocyclohexane results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

sorbitol dehydrogenase

affects activity

Hexachlorocyclohexane affects the activity of SORD protein

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

sprouty RTK signaling antagonist 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SPRY1 mRNA

NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189

G

squalene epoxidase

increases expression

Hexachlorocyclohexane results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sequestosome 1

increases expression

Hexachlorocyclohexane results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

serine and arginine rich splicing factor 2

increases expression

Hexachlorocyclohexane results in increased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

sulfiredoxin 1

increases expression

Hexachlorocyclohexane results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

signal transducing adaptor molecule 2

increases expression

Hexachlorocyclohexane results in increased expression of STAM2 mRNA

NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression
increases expression

Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]
Hexachlorocyclohexane results in decreased expression of STAR protein
Hexachlorocyclohexane results in increased expression of STAR protein
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]
Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]
Hexachlorocyclohexane results in increased expression of STAR mRNA

PMID:10993823 PMID:15749814 PMID:17080404 PMID:18248869

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

sulfotransferase family 1A member 1

decreases expression

Hexachlorocyclohexane results in decreased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

multiple interactions
decreases expression

Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]
Hexachlorocyclohexane results in decreased expression of SULT2A1 mRNA

PMID:9566755 PMID:17080404

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

transcription factor A, mitochondrial

increases expression

Hexachlorocyclohexane results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor B2, mitochondrial

increases expression

Hexachlorocyclohexane results in increased expression of TFB2M mRNA

NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657

G

transforming growth factor, beta 1

multiple interactions

Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tight junction protein 1

affects localization
multiple interactions
decreases expression

Hexachlorocyclohexane affects the localization of TJP1 protein
Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
Hexachlorocyclohexane results in decreased expression of TJP1 protein

PMID:11532877 PMID:15194225

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

multiple interactions
increases expression

[Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TLR4 protein
Hexachlorocyclohexane results in increased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane 6 superfamily member 1

increases expression

Hexachlorocyclohexane results in increased expression of TM6SF1 mRNA

NCBI chr 1:135,799,844...135,828,515
Ensembl chr 1:135,786,381...135,828,443

G

transmembrane and coiled-coil domains 6

decreases expression

Hexachlorocyclohexane results in decreased expression of TMCO6 mRNA

NCBI chr18:28,349,248...28,355,843
Ensembl chr18:28,349,248...28,355,843

G

transmembrane protein 177

decreases expression

Hexachlorocyclohexane results in decreased expression of TMEM177 mRNA

NCBI chr13:31,023,893...31,027,368
Ensembl chr13:31,023,455...31,027,378

G

transmembrane protein 267

increases expression

Hexachlorocyclohexane results in increased expression of TMEM267 mRNA

NCBI chr 2:51,580,210...51,588,937
Ensembl chr 2:51,581,252...51,587,636

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression

[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
[Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein
Lindane increases expression of Tnf protein in serum
Hexachlorocyclohexane results in increased expression of TNF mRNA; Hexachlorocyclohexane results in increased expression of TNF protein
Hexachlorocyclohexane results in decreased expression of TNF protein

CTD
RGD

PMID:15019085 PMID:15025948 PMID:15135310 PMID:15319175 PMID:28177269 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tenascin XA, pseudogene 1

affects expression

Hexachlorocyclohexane affects the expression of TNXA mRNA

NCBI chr20:4,026,471...4,027,826

G

torsin 1A interacting protein 1

increases expression

Hexachlorocyclohexane results in increased expression of TOR1AIP1 mRNA

NCBI chr13:68,196,681...68,226,121
Ensembl chr13:68,196,681...68,225,862

G

tumor protein p53

multiple interactions

[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 3

affects expression

Hexachlorocyclohexane affects the expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

transformer 2 beta

affects expression

Hexachlorocyclohexane affects the expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

tribbles pseudokinase 3

increases expression

Hexachlorocyclohexane results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tubulin, alpha 4A

decreases expression

Hexachlorocyclohexane results in decreased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

G

thioredoxin 2

decreases expression

Hexachlorocyclohexane results in decreased expression of TXN2 mRNA

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

TYRO3 protein tyrosine kinase

affects expression

Hexachlorocyclohexane affects the expression of TYRO3 mRNA

NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142

G

UDP glucuronosyltransferase family 1 member A1

increases activity

Hexachlorocyclohexane results in increased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Hexachlorocyclohexane results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

increases expression

Hexachlorocyclohexane results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide

decreases response to substance
multiple interactions

Hexachlorocyclohexane results in decreased susceptibility to VIP protein
Hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]

PMID:2467674 PMID:4120787 PMID:20732086

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

very low density lipoprotein receptor

increases expression

Hexachlorocyclohexane results in increased expression of VLDLR mRNA

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

WASP like actin nucleation promoting factor

increases expression

Hexachlorocyclohexane results in increased expression of WASL mRNA

NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022

G

zinc finger protein 354A

increases expression

Hexachlorocyclohexane results in increased expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 628

decreases expression

Hexachlorocyclohexane results in decreased expression of ZNF628 mRNA

NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243

malaoxon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

[malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]
malaoxon metabolite results in decreased activity of ACHE protein; malaoxon results in decreased activity of ACHE protein
Dichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]; K075 compound inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]

PMID:597376 PMID:4859365 PMID:8783813 PMID:9268605 PMID:9515941 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

albumin

affects binding

malaoxon binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

butyrylcholinesterase

affects binding

malaoxon binds to BCHE protein; malaoxon binds to BCHE protein modified form

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

increases expression

malaoxon results in increased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

decreases expression

malaoxon results in decreased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

claudin 5

multiple interactions
decreases expression

[malaoxon co-treated with Lead] results in decreased expression of CLDN5 protein
malaoxon results in decreased expression of CLDN5 protein

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

glutamic-oxaloacetic transaminase 1

increases secretion
multiple interactions

malaoxon results in increased secretion of GOT1 protein
[malaoxon co-treated with Obidoxime Chloride] results in increased secretion of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

heme oxygenase 1

increases expression

malaoxon results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

occludin

multiple interactions
decreases expression

[malaoxon co-treated with Lead] results in decreased expression of OCLN protein
malaoxon results in decreased expression of OCLN protein

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

patatin-like phospholipase domain containing 6

decreases activity

malaoxon results in decreased activity of PNPLA6 protein

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

paraoxonase 1

multiple interactions

PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]; PON1 affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate co-treated with malaoxon]

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

prostaglandin-endoperoxide synthase 2

increases expression

malaoxon results in increased expression of PTGS2 mRNA; malaoxon results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

increases expression

malaoxon results in increased expression of RELA mRNA

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

signal transducer and activator of transcription 3

decreases phosphorylation

malaoxon results in decreased phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tight junction protein 1

multiple interactions
decreases expression

[malaoxon co-treated with Lead] results in decreased expression of TJP1 protein
malaoxon results in decreased expression of TJP1 protein

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tight junction protein 2

multiple interactions
decreases expression

[malaoxon co-treated with Lead] results in decreased expression of TJP2 protein
malaoxon results in decreased expression of TJP2 protein

NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

malaoxon results in increased expression of TRPC1 mRNA; malaoxon results in increased expression of TRPC1 protein

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

transient receptor potential cation channel, subfamily C, member 4

increases expression

malaoxon results in increased expression of TRPC4 mRNA; malaoxon results in increased expression of TRPC4 protein

NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768

malathion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA binding domain containing 5

increases expression

Malathion results in increased expression of ACBD5 mRNA

NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215

G

acetylcholinesterase

multiple interactions
decreases activity

[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]
[Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]

PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA thioesterase 6

decreases expression

Malathion results in decreased expression of ACOT6 mRNA

NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

Malathion results in decreased expression of ACSM1 mRNA

NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495

G

ADAM metallopeptidase domain 11

increases methylation

Malathion results in increased methylation of ADAM11 promoter

NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562

G

ADAM metallopeptidase domain 32

decreases expression

Malathion results in decreased expression of ADAM32 mRNA

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

Malathion results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

ADAM metallopeptidase with thrombospondin type 1 motif, 20

decreases expression

Malathion results in decreased expression of ADAMTS20 mRNA

NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:125,397,734...125,527,777

G

ADAM metallopeptidase with thrombospondin type 1 motif, 6

increases expression

Malathion results in increased expression of ADAMTS6 mRNA

NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298

G

adducin 3

increases expression

Malathion results in increased expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

adrenomedullin

increases expression

Malathion results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor alpha 2A

increases expression

Malathion results in increased expression of ADRA2A mRNA

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

ALF transcription elongation factor 1

increases expression

Malathion results in increased expression of AFF1 mRNA mutant form

NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729

G

aryl hydrocarbon receptor

multiple interactions

[prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1, member C1

increases expression

Malathion results in increased expression of AKR1C1 mRNA

PMID:16079077 PMID:18214805

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

increases expression

Malathion results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member E2

decreases expression

Malathion results in decreased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

G

ALK and LTK ligand 2

increases expression

Malathion results in increased expression of ALKAL2 mRNA

NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

Malathion results in increased activity of ALPL protein
thymoquinone inhibits the reaction [Malathion results in increased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiomotin

decreases expression

Malathion results in decreased expression of AMOT mRNA

NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272

G

angiopoietin-like 2

decreases expression

Malathion results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin-like 4

decreases methylation
increases expression

Malathion results in decreased methylation of ANGPTL4 promoter
Malathion results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin 1

decreases expression

Malathion results in decreased expression of ANK1 mRNA

NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759

G

ankyrin repeat domain 55

increases expression

Malathion results in increased expression of ANKRD55 mRNA

NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:43,883,857...43,983,680

G

aprataxin and PNKP like factor

decreases expression

Malathion results in decreased expression of APLF mRNA

NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633

G

aquaporin 12A

decreases expression

Malathion results in decreased expression of AQP12A mRNA

NCBI chr 9:93,554,527...93,560,011
Ensembl chr 9:93,554,527...93,560,011

G

aquaporin 9

increases expression

Malathion results in increased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

androgen receptor

multiple interactions
decreases expression

[terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein
Malathion results in decreased expression of AR mRNA

PMID:23871939 PMID:36336997

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

armadillo repeat containing 3

decreases expression

Malathion results in decreased expression of ARMC3 mRNA

NCBI chr17:81,814,087...81,917,534
Ensembl chr17:81,832,518...81,917,531

G

aryl hydrocarbon receptor nuclear translocator 2

decreases expression

Malathion results in decreased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

acid sensing ion channel subunit family member 5

increases expression

Malathion results in increased expression of ASIC5 mRNA

NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

Malathion results in decreased expression of ATP2B3 mRNA

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

beta-1,4-galactosyltransferase 1

decreases expression

Malathion results in decreased expression of B4GALT1 mRNA

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

B9 domain containing 1

decreases expression

Malathion results in decreased expression of B9D1 mRNA

NCBI chr10:46,186,222...46,196,309
Ensembl chr10:46,186,691...46,196,008

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions
increases expression

Malathion results in decreased expression of BAX mRNA
Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin inhibits the reaction [Malathion results in increased expression of BAX protein]

PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions
decreases activity
increases activity

Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]
Malathion results in increased activity of BCHE protein

PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
increases expression

Malathion results in decreased expression of BCL2 mRNA
Malathion results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
Malathion results in increased expression of BCL2 protein
Malathion results in increased expression of BCL2 mRNA

PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions

[Pesticides results in increased abundance of Malathion metabolite] which results in decreased secretion of BDNF protein; [Pesticides results in increased abundance of Malathion metabolite] which results in increased methylation of BDNF gene

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

Malathion results in increased expression of BIRC5 protein
Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of BIRC5 protein]; thymoquinone inhibits the reaction [Malathion results in increased expression of BIRC5 protein]

PMID:33510276 PMID:34262720

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BMI1 proto-oncogene, polycomb ring finger

increases expression

Malathion results in increased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

bromodomain containing 7

increases expression

Malathion results in increased expression of BRD7 mRNA

NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494

G

barttin CLCNK type accessory subunit beta

increases expression

Malathion results in increased expression of BSND mRNA

NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571

G

BTG anti-proliferation factor 1

decreases expression

Malathion results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Malathion results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

similar to human chromosome 10 open reading frame 53

decreases expression

Malathion results in decreased expression of C10ORF53 mRNA

NCBI chr16:7,634,207...7,644,876
Ensembl chr16:7,634,207...7,644,876

G

complement C1q like 2

decreases expression

Malathion results in decreased expression of C1QL2 mRNA

NCBI chr13:31,471,150...31,472,685
Ensembl chr13:31,471,150...31,472,689

G

similar to human chromosome 3 open reading frame 80

decreases expression

Malathion results in decreased expression of C3ORF80 mRNA

NCBI chr 2:153,125,312...153,128,124
Ensembl chr 2:153,125,676...153,126,419

G

similar to human chromosome 11 open reading frame 96

increases expression

Malathion results in increased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

similar to human chromosome 15 open reading frame 48

increases expression

Malathion results in increased expression of C15ORF48 mRNA

NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006

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similar to human chromosome 8 open reading frame 34

decreases expression

Malathion results in decreased expression of C8ORF34 mRNA

NCBI chr 5:7,237,968...7,777,119
Ensembl chr 5:7,238,853...7,776,769

G

similar to human chromosome 12 open reading frame 54

decreases expression

Malathion results in decreased expression of C12ORF54 mRNA

NCBI chr 7:129,529,811...129,548,676

G

calcium binding protein 7

decreases expression

Malathion results in decreased expression of CABP7 mRNA

NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240

G

calcium voltage-gated channel subunit alpha1 C

increases expression

Malathion results in increased expression of CACNA1C mRNA

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

multiple interactions

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calpain 8

decreases expression

Malathion results in decreased expression of CAPN8 mRNA

NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146

G

CART prepropeptide

increases expression

Malathion results in increased expression of CARTPT mRNA

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

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caspase 3

increases activity
multiple interactions
increases expression
increases cleavage

Malathion results in increased activity of CASP3 protein
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]

PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 4

decreases expression

Malathion results in decreased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

increases activity

Malathion results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

increases activity
increases expression
multiple interactions
increases cleavage

Malathion results in increased activity of CASP9 protein
Malathion results in increased expression of CASP9 mRNA
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]

PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

multiple interactions
decreases activity
increases activity
decreases expression

[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
[Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]

PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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core-binding factor subunit beta

increases expression

Malathion results in increased expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

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coiled-coil domain containing 126

increases expression

Malathion results in increased expression of CCDC126 mRNA

NCBI chr 4:78,297,625...78,318,655
Ensembl chr 4:78,297,551...78,318,655

G

cholecystokinin

increases expression

Malathion results in increased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 1

increases expression

Malathion results in increased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 19

increases expression

Malathion results in increased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

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C-C motif chemokine ligand 20

increases expression

Malathion results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

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C-C motif chemokine ligand 3

increases expression

Malathion results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

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C-C motif chemokine ligand 7

increases expression

Malathion results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

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CCM2 like scaffold protein

increases expression

Malathion results in increased expression of CCM2L mRNA

NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140

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cyclin A2

decreases expression

Malathion results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

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cyclin B1

decreases expression

Malathion results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

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cyclin E1

decreases expression

Malathion results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

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coiled-coil serine-rich protein 1

increases expression

Malathion results in increased expression of CCSER1 mRNA

NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786

G

CD14 molecule

decreases expression

Malathion results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

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CD274 molecule

increases expression

Malathion results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

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CD36 molecule

increases expression

Malathion results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

Cd5 molecule

decreases expression

Malathion results in decreased expression of CD5 mRNA

NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313

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Cd69 molecule

increases expression

Malathion results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

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cell division cycle 20

decreases expression

Malathion results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cyclin-dependent kinase 15

increases expression

Malathion results in increased expression of CDK15 mRNA

NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777

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cyclin dependent kinase 2

decreases expression
increases expression

Malathion results in decreased expression of CDK2 protein
Malathion results in increased expression of CDK2 mRNA

PMID:30769050 PMID:32069766

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

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CCAAT/enhancer binding protein gamma

increases expression

Malathion results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

centromere protein F

decreases expression

Malathion results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

carboxylesterase 1D

increases expression

Malathion results in increased expression of CES1 mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cilia and flagella associated protein 157

decreases expression

Malathion results in decreased expression of CFAP157 mRNA

NCBI chr 3:16,066,521...16,073,504
Ensembl chr 3:16,066,521...16,073,495

G

cilia and flagella associated protein 91

decreases expression

Malathion results in decreased expression of CFAP91 mRNA

NCBI chr11:62,413,613...62,457,281
Ensembl chr11:62,413,602...62,457,293

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complement factor B

increases expression

Malathion results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

cholesterol 25-hydroxylase

increases expression

Malathion results in increased expression of CH25H mRNA

NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195

G

claudin 12

increases expression

Malathion results in increased expression of CLDN12 mRNA

NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801

G

claudin 22

decreases expression

Malathion results in decreased expression of CLDN22 mRNA

NCBI chr16:44,422,344...44,423,370
Ensembl chr16:44,422,345...44,423,354

G

claudin 5

multiple interactions
decreases expression

[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein
Malathion results in decreased expression of CLDN5 protein

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

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chymase 1

decreases expression

Malathion results in decreased expression of CMA1 mRNA

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

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contactin 4

increases expression

Malathion results in increased expression of CNTN4 mRNA

NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090

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collagen type I alpha 2 chain

increases expression

Malathion results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

copine family member 9

decreases expression

Malathion results in decreased expression of CPNE9 mRNA

NCBI chr 4:146,429,961...146,454,335
Ensembl chr 4:146,430,792...146,454,333

G

carboxypeptidase Z

decreases expression

Malathion results in decreased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

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corticotropin releasing hormone

multiple interactions
decreases expression

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

PMID:20233601 PMID:25404496

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

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cysteine-rich secretory protein 3

decreases expression

Malathion results in decreased expression of CRISP3 mRNA

NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658

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cysteine-rich secretory protein LCCL domain containing 2

decreases expression

Malathion results in decreased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

colony stimulating factor 2

increases expression

Malathion results in increased expression of CSF2 protein
Malathion results in increased expression of CSF2 mRNA

PMID:34778934 PMID:37047231

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression

Malathion results in increased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cathepsin D

increases expression

Malathion results in increased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 11

increases expression

Malathion results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

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cytochrome b-245 beta chain

multiple interactions
increases expression

Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

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cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

Malathion results in decreased expression of CYP11A1 mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

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cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

[bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

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cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases expression

CYP1A2 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP1A2 mRNA

PMID:15557345 PMID:22310298

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

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cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

Malathion results in increased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

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cytochrome P450, family 2, subfamily b, polypeptide 3

affects metabolic processing
decreases activity
increases expression
multiple interactions

CYP2B6 protein affects the metabolism of Malathion
Malathion results in decreased activity of CYP2B6 protein
Malathion results in increased expression of CYP2B6 mRNA
Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]

PMID:15557345 PMID:22310298 PMID:24333466

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

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cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Malathion results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

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cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing
increases expression

[Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A4 mRNA

PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

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cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing
increases expression

CYP3A5 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A5 mRNA

PMID:17110060 PMID:37047231

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

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cytochrome P450 family 8 subfamily B member 1

multiple interactions

[Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

decorin

increases expression

Malathion results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

dopa decarboxylase

affects binding
increases expression

Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein
Malathion results in increased expression of DDC mRNA

PMID:35151785 PMID:37047231

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

discoidin domain receptor tyrosine kinase 1

decreases expression

Malathion results in decreased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

DEAD/H-box helicase 11

increases expression

Malathion results in increased expression of DDX11 mRNA

NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550

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iodothyronine deiodinase 1

decreases expression

Malathion results in decreased expression of DIO1 mRNA

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

DISC1 scaffold protein

increases expression

Malathion results in increased expression of DISC1 mRNA

NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778

G

dickkopf WNT signaling pathway inhibitor 2

increases expression

Malathion results in increased expression of DKK2 mRNA

NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225

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discs large MAGUK scaffold protein 2

increases expression

Malathion results in increased expression of DLG2 mRNA

NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475

G

DNA methyltransferase 1

decreases expression

Malathion results in decreased expression of DNMT1 mRNA

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

affects expression

Malathion affects the expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

affects expression

Malathion affects the expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

double C2 domain beta

decreases expression

Malathion results in decreased expression of DOC2B mRNA

NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267

G

desmoplakin

increases expression

Malathion results in increased expression of DSP mRNA

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

G

dentin sialophosphoprotein

decreases expression

Malathion results in decreased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

dystrobrevin, alpha

decreases expression

Malathion results in decreased expression of DTNA mRNA

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261

G

dual oxidase 1

multiple interactions
increases expression

Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein]

NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563

G

dual specificity phosphatase 1

decreases expression

Malathion results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 5

increases expression

Malathion results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dishevelled segment polarity protein 1

increases expression

Malathion results in increased expression of DVL1 mRNA

NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664

G

Epstein-Barr virus induced 3

increases expression

Malathion results in increased expression of EBI3 mRNA

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

endothelin 1

increases expression

Malathion results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type B

decreases expression

Malathion results in decreased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EF-hand calcium binding domain 9

increases expression

Malathion results in increased expression of EFCAB9 mRNA

NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,107,123...17,112,289

G

EH domain binding protein 1

increases response to substance

EHBP1 gene SNP results in increased susceptibility to Malathion

NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332

G

engrailed homeobox 1

decreases expression

Malathion results in decreased expression of EN1 mRNA

NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943

G

enkurin, TRPC channel interacting protein

increases expression

Malathion results in increased expression of ENKUR mRNA

NCBI chr17:83,690,105...83,714,756
Ensembl chr17:83,690,797...83,714,408

G

EPH receptor A10

increases expression

Malathion results in increased expression of EPHA10 mRNA

NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157

G

Eph receptor A4

increases expression

Malathion results in increased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

epoxide hydrolase 1

decreases expression

Malathion results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

elongin BC and polycomb repressive complex 2 associated protein

increases expression

Malathion results in increased expression of EPOP mRNA

NCBI chr10:82,624,392...82,625,912
Ensembl chr10:82,624,392...82,625,912

G

EPS8-like 1

increases expression

Malathion results in increased expression of EPS8L1 mRNA

NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524

G

erb-b2 receptor tyrosine kinase 4

increases expression

Malathion results in increased expression of ERBB4 mRNA

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

estrogen receptor 1

decreases activity

Malathion results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ETS variant transcription factor 6

increases expression

Malathion results in increased expression of ETV6 mRNA mutant form

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

coagulation factor III, tissue factor

increases expression

Malathion results in increased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

family with sequence similarity 124 member A

increases expression

Malathion results in increased expression of FAM124A mRNA

NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683

G

family with sequence similarity 227, member B

decreases expression

Malathion results in decreased expression of FAM227B mRNA

NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:113,233,205...113,392,320

G

family with sequence similarity 229, member B

decreases expression

Malathion results in decreased expression of FAM229B mRNA

NCBI chr20:42,538,853...42,552,355
Ensembl chr20:42,538,868...42,552,248

G

fibroblast growth factor 22

decreases expression

Malathion results in decreased expression of FGF22 mRNA

NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486

G

fibroblast growth factor 6

increases expression

Malathion results in increased expression of FGF6 mRNA

NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447

G

fibroblast growth factor binding protein 1

increases expression

Malathion results in increased expression of FGFBP1 mRNA

NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496

G

Fibroblast growth factor receptor 1

increases expression

Malathion results in increased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibrinogen gamma chain

decreases expression

Malathion results in decreased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

filamin A interacting protein 1-like

increases expression

Malathion results in increased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

Fms related receptor tyrosine kinase 4

increases expression

Malathion results in increased expression of FLT4 mRNA

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

forkhead box O1

decreases expression
multiple interactions
increases methylation

Malathion results in decreased expression of FOXO1 mRNA
[Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O4

increases expression

Malathion results in increased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

follicle stimulating hormone receptor

increases expression

Malathion results in increased expression of FSHR mRNA

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphate dehydrogenase

multiple interactions
increases activity

[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
Malathion results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate decarboxylase 1

affects binding

Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

affects binding

Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

polypeptide N-acetylgalactosaminyltransferase 16

increases expression

Malathion results in increased expression of GALNT16 mRNA

NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705

G

golgi associated RAB2 interactor family member 2

decreases expression

Malathion results in decreased expression of GARIN2 mRNA

NCBI chr 6:97,489,562...97,534,729
Ensembl chr 6:97,490,368...97,534,763

G

growth arrest-specific 2

increases expression

Malathion results in increased expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619

G

GATA binding protein 4

decreases expression

Malathion results in decreased expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

guanylate binding protein 1

increases expression

Malathion results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 3

increases expression

Malathion results in increased expression of GBP3 mRNA

NCBI chr 2:231,460,032...231,500,266
Ensembl chr 2:231,486,062...231,493,098

G

guanylate binding protein 5

increases expression

Malathion results in increased expression of GBP5 mRNA

NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061

G

glycerol kinase

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glycerol kinase 2

decreases expression

Malathion results in decreased expression of GK2 mRNA

NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,107,020...12,128,473

G

geminin coiled-coil domain containing

increases expression

Malathion results in increased expression of GMNC mRNA

NCBI chr11:73,836,255...73,847,698
Ensembl chr11:73,814,533...73,847,328

G

G protein subunit alpha i1

increases expression

Malathion results in increased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

decreases expression

Malathion results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases activity

thymoquinone inhibits the reaction [Malathion results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic-oxaloacetic transaminase 1-like 1

increases expression

Malathion results in increased expression of GOT1L1 mRNA

NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162

G

glycoprotein V (platelet)

increases expression

Malathion results in increased expression of GP5 mRNA

NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705

G

G protein-coupled receptor 179

decreases expression

Malathion results in decreased expression of GPR179 mRNA

NCBI chr10:82,324,568...82,340,448
Ensembl chr10:82,337,771...82,340,448

G

G protein pathway suppressor 2

decreases expression

Malathion results in decreased expression of GPS2 mRNA

NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

Malathion results in increased activity of GPT protein
thymoquinone inhibits the reaction [Malathion results in increased activity of GPT protein]

PMID:25180440 PMID:33510276 PMID:36370973

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

GRAM domain containing 4

decreases expression

Malathion results in decreased expression of GRAMD4 mRNA

NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053

G

G protein-coupled receptor kinase 1

increases expression

Malathion results in increased expression of GRK1 mRNA

NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792

G

glycogen synthase kinase 3 beta

increases expression

Malathion results in increased expression of GSK3B mRNA

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions
decreases activity

[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein
Malathion results in decreased activity of GSR protein
zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]

PMID:16718366 PMID:19429256

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

decreases expression

Malathion results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

granzyme B

decreases expression
multiple interactions

Malathion results in decreased expression of GZMB protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

H19 imprinted maternally expressed transcript

increases expression

Malathion results in increased expression of H19 mRNA

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

hyaluronan synthase 1

increases expression

Malathion results in increased expression of HAS1 mRNA

NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397

G

heparin-binding EGF-like growth factor

increases expression

Malathion results in increased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

histidine decarboxylase

affects binding

Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

hypoxia inducible lipid droplet-associated

increases expression

Malathion results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

heme oxygenase 1

increases expression

Malathion results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine N-methyltransferase

decreases expression

Malathion results in decreased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

HRas proto-oncogene, GTPase

multiple interactions
increases expression

[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA
Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein

PMID:18204794 PMID:19787260

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA]

PMID:30409133 PMID:36336997

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

heat shock transcription factor 2 binding protein

increases expression

Malathion results in increased expression of HSF2BP mRNA

NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242

G

heat shock protein family B (small) member 2

increases expression

Malathion results in increased expression of HSPB2 protein

NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533

G

HIV-1 Tat interactive protein 2

decreases expression

Malathion results in decreased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

HtrA serine peptidase 4

decreases expression

Malathion results in decreased expression of HTRA4 mRNA

NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074

G

indoleamine 2,3-dioxygenase 1

increases expression

Malathion results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon-induced protein 44-like

increases expression

Malathion results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon beta 1

multiple interactions

Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

decreases expression
multiple interactions
increases expression

Malathion results in decreased expression of IFNG protein
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein]

PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 11

increases expression

Malathion results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 13

increases expression

Malathion results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 13 receptor subunit alpha 2

increases expression

Malathion results in increased expression of IL13RA2 mRNA

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

interleukin 1 alpha

increases expression

Malathion results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]
Malathion results in decreased expression of IL1B protein

PMID:24810974 PMID:25180440 PMID:28987951 PMID:32495713 PMID:37047231

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 2

decreases expression

Malathion results in decreased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 2

multiple interactions
decreases expression

Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 23 subunit alpha

increases expression

Malathion results in increased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 24

increases expression

Malathion results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 36, gamma

increases expression

Malathion results in increased expression of IL36G mRNA

NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480

G

interleukin 4

decreases expression
multiple interactions

Malathion results in decreased expression of IL4 protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression
decreases expression

Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]
Malathion results in decreased expression of IL6 protein

PMID:24810974 PMID:25180440 PMID:32495713 PMID:37047231

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

increases expression
decreases methylation

Malathion results in increased expression of INHBA mRNA
Malathion results in decreased methylation of INHBA promoter

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

insulin 1

increases expression

Malathion results in increased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

interleukin-1 receptor-associated kinase 1

increases expression

Malathion results in increased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interleukin-1 receptor-associated kinase 2

increases expression

Malathion results in increased expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

iroquois homeobox 2

increases expression

Malathion results in increased expression of IRX2 mRNA

NCBI chr 1:30,660,960...30,666,378
Ensembl chr 1:30,660,960...30,666,378

G

integrin subunit beta 8

decreases methylation
increases expression

Malathion results in decreased methylation of ITGB8 promoter
Malathion results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

kazrin, periplakin interacting protein

decreases expression

Malathion results in decreased expression of KAZN mRNA

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

G

potassium voltage-gated channel subfamily H member 5

increases expression

Malathion results in increased expression of KCNH5 mRNA

NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:93,624,529...93,908,107

G

potassium calcium-activated channel subfamily M alpha 1

increases methylation
decreases expression

Malathion results in increased methylation of KCNMA1 promoter
Malathion results in decreased expression of KCNMA1 mRNA

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

kinesin family member 6

decreases expression

Malathion results in decreased expression of KIF6 mRNA

NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006

G

KIT proto-oncogene receptor tyrosine kinase

increases expression
multiple interactions

Malathion results in increased expression of KIT protein
Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of KIT protein]; thymoquinone inhibits the reaction [Malathion results in increased expression of KIT protein]

PMID:33510276 PMID:34262720

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lysine methyltransferase 2A

increases mutagenesis
increases expression

Malathion results in increased mutagenesis of KMT2A gene
Malathion results in increased expression of KMT2A mRNA mutant form

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

keratin 14

increases expression

Malathion results in increased expression of KRT14 mRNA

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

keratin 17

increases expression

Malathion results in increased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin associated protein 27-1

increases expression

Malathion results in increased expression of KRTAP27-1 mRNA

NCBI chr11:27,980,875...27,982,002

G

LINE-1 type transposase domain containing 1

affects expression
increases methylation
multiple interactions

Malathion affects the expression of L1TD1 mRNA
Malathion results in increased methylation of L1TD1 promoter
[Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA

NCBI chr 5:113,373,193...113,386,088
Ensembl chr 5:113,379,870...113,385,730

G

linker for activation of T cells

increases expression

Malathion results in increased expression of LAT mRNA

NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578

G

ligand dependent nuclear receptor corepressor-like

increases expression

Malathion results in increased expression of LCORL mRNA

NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174

G

LEM domain containing 1

increases expression

Malathion results in increased expression of LEMD1 mRNA

NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948

G

galectin 1

decreases expression

Malathion results in decreased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LIF, interleukin 6 family cytokine

increases expression

Malathion results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lin-28 homolog B

increases expression

Malathion results in increased expression of LIN28B mRNA

NCBI chr20:48,865,329...48,964,769
Ensembl chr20:48,869,485...48,955,077

G

leucine rich repeat and Ig domain containing 1

decreases expression

Malathion results in decreased expression of LINGO1 mRNA

NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544

G

limb development membrane protein 1

increases expression

Malathion results in increased expression of LMBR1 mRNA

NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368

G

mucin-12-like

decreases expression

Malathion results in decreased expression of MUC12 mRNA

NCBI chr12:19,486,041...19,493,995

G

lysophosphatidylcholine acyltransferase 4

increases expression

Malathion results in increased expression of LPCAT4 mRNA

NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875

G

leucine-rich repeats and guanylate kinase domain containing

decreases expression

Malathion results in decreased expression of LRGUK mRNA

NCBI chr 4:62,647,222...62,770,268
Ensembl chr 4:62,647,264...62,770,319

G

LDL receptor related protein 3

decreases expression

Malathion results in decreased expression of LRP3 mRNA

NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110

G

Ly6/Plaur domain containing 1

decreases expression

Malathion results in decreased expression of LYPD1 mRNA

NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493

G

leucine zipper tumor suppressor 1

increases expression

Malathion results in increased expression of LZTS1 mRNA

NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203

G

leucine zipper tumor suppressor 2

decreases expression

Malathion results in decreased expression of LZTS2 mRNA

NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423

G

mono-ADP ribosylhydrolase 2

decreases expression

Malathion results in decreased expression of MACROD2 mRNA

NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492

G

mitogen activated protein kinase kinase 3

decreases expression

Malathion results in decreased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

membrane associated ring-CH-type finger 3

increases expression

Malathion results in increased expression of MARCHF3 mRNA

NCBI chr18:50,237,218...50,389,343
Ensembl chr18:50,237,230...50,389,150

G

myelin basic protein

decreases expression

Malathion results in decreased expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

minichromosome maintenance complex component 2

multiple interactions
increases expression

[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA
Malathion results in increased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

Meis homeobox 1

decreases expression

Malathion results in decreased expression of MEIS1 mRNA

NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Malathion results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

Malathion results in increased expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

MHC I like leukocyte 1

increases expression

Malathion results in increased expression of MICA mRNA

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

G

matrix metallopeptidase 1

increases expression

Malathion results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 10

increases expression

Malathion results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 12

increases expression

Malathion results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 3

increases expression

Malathion results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myeloperoxidase

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein]

PMID:24810974 PMID:25180440

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

Malathion results in decreased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase III

decreases expression

Malathion results in decreased expression of COX3 mRNA

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

metallothionein 1, pseudogene 3

increases expression

Malathion results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

Malathion results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

myosin binding protein H-like

increases expression

Malathion results in increased expression of MYBPHL mRNA

NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824

G

myosin Ib

increases expression

Malathion results in increased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myocardial zonula adherens protein

increases expression

Malathion results in increased expression of MYZAP mRNA

NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036

G

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

Malathion results in decreased expression of NDUFS7 mRNA

NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195

G

neurofilament heavy chain

affects expression
increases expression

Malathion affects the expression of NEFH mRNA
Malathion results in increased expression of NEFH mRNA

PMID:22954530 PMID:28385489

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

NIMA-related kinase 10

decreases expression

Malathion results in decreased expression of NEK10 mRNA

NCBI chr15:10,387,063...10,564,177
Ensembl chr15:10,381,140...10,559,722

G

neuraminidase 4

increases expression

Malathion results in increased expression of NEU4 mRNA

NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576

G

neuralized E3 ubiquitin protein ligase 3

increases expression

Malathion results in increased expression of NEURL3 mRNA

NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649

G

NFE2 like bZIP transcription factor 2

increases activity

Malathion results in increased activity of NFE2L2 protein

PMID:30114225 PMID:30203046

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor I/B

decreases expression

Malathion results in decreased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nerve growth factor

multiple interactions

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

ninjurin 1

decreases expression

Malathion results in decreased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

nicotinamide nucleotide transhydrogenase

decreases expression

Malathion results in decreased expression of NNT mRNA

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

nitric oxide synthase 2

increases expression

Malathion results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression

Malathion results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity

Malathion results in increased expression of NR1I3 mRNA
Malathion results in increased activity of NR1I3 protein

PMID:22310298 PMID:28927721 PMID:30203046

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Malathion results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 3

decreases methylation
increases expression

Malathion results in decreased methylation of NR4A3 promoter
Malathion results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

netrin 1

increases expression

Malathion results in increased expression of NTN1 mRNA

NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326

G

neurotrophic receptor tyrosine kinase 2

increases expression

Malathion results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

occludin

multiple interactions
decreases expression

[Malathion co-treated with Lead] results in decreased expression of OCLN protein
Malathion results in decreased expression of OCLN protein

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

osteoclast stimulatory transmembrane protein

increases expression

Malathion results in increased expression of OCSTAMP mRNA

NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991

G

odontogenic, ameloblast associated

decreases expression

Malathion results in decreased expression of ODAM mRNA

NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517

G

outer dense fiber of sperm tails 2-like

decreases expression

Malathion results in decreased expression of ODF2L mRNA

NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747

G

olfactory receptor 1433

increases expression

Malathion results in increased expression of OR2W3 mRNA

NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701

G

olfactory receptor 1523

decreases expression

Malathion results in decreased expression of OR4D1 mRNA

NCBI chr10:72,708,272...72,709,213
Ensembl chr10:72,707,063...72,715,311

G

olfactory receptor 35

decreases expression

Malathion results in decreased expression of OR2AT4 mRNA

NCBI chr 1:153,994,678...154,043,281
Ensembl chr 1:154,041,306...154,043,257

G

oligodendrocyte-myelin glycoprotein

affects expression

Malathion affects the expression of OMG mRNA

NCBI chr10:64,461,350...64,464,084
Ensembl chr10:64,461,350...64,464,084

G

opsin 5

decreases expression

Malathion results in decreased expression of OPN5 mRNA

NCBI chr 9:18,368,393...18,416,098
Ensembl chr 9:18,368,416...18,415,476

G

olfactory receptor family 4 subfamily F member 7C

decreases expression

Malathion results in decreased expression of OR4F21 mRNA

NCBI chr 3:98,458,889...98,459,827
Ensembl chr 3:98,457,871...98,464,794

G

olfactory receptor family 6 subfamily C member 2

decreases expression

Malathion results in decreased expression of OR6C2 mRNA

NCBI chr 7:2,188,601...2,189,539
Ensembl chr 7:2,182,984...2,189,667

G

olfactory receptor family 9 subfamily G member 4

decreases expression

Malathion results in decreased expression of OR9G4 mRNA

NCBI chr 3:70,727,963...70,728,901
Ensembl chr 3:70,726,935...70,732,439

G

purinergic receptor P2X 1

increases expression

Malathion results in increased expression of P2RX1 mRNA

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

G

palmdelphin

decreases expression

Malathion results in decreased expression of PALMD mRNA

NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

Malathion results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 1

increases expression

Malathion results in increased expression of PAX1 mRNA

NCBI chr 3:134,792,330...134,801,637
Ensembl chr 3:134,789,182...134,801,636

G

protocadherin related 15

decreases expression

Malathion results in decreased expression of PCDH15 mRNA

NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719

G

protocadherin beta 19

decreases expression

Malathion results in decreased expression of PCDHB12 mRNA

NCBI chr18:29,204,838...29,207,646

G

protocadherin gamma subfamily B, 1

increases expression

Malathion results in increased expression of PCDHGB1 mRNA

NCBI chr18:29,501,739...29,508,024

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

proliferating cell nuclear antigen

multiple interactions
increases expression

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphodiesterase 6C

decreases expression

Malathion results in decreased expression of PDE6C mRNA

NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315

G

protein disulfide isomerase family A, member 2

decreases expression

Malathion results in decreased expression of PDIA2 mRNA

NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931

G

phosphatidylethanolamine binding protein 1

decreases expression

Malathion results in decreased expression of PEBP1 mRNA

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

paternally expressed 10

increases expression

Malathion results in increased expression of PEG10 mRNA

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

profilin 1

decreases expression

Malathion results in decreased expression of PFN1 mRNA

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

prohibitin 1

decreases expression

Malathion results in decreased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

paired-like homeodomain 1

decreases expression

Malathion results in decreased expression of PITX1 mRNA

NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291

G

plasminogen activator, tissue type

decreases expression

Malathion results in decreased expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

increases expression

Malathion results in increased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

increases expression

Malathion results in increased expression of PLAUR mRNA

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C, beta 4

increases expression

Malathion results in increased expression of PLCB4 mRNA

NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392

G

pleckstrin homology and coiled-coil domain containing D1

decreases expression

Malathion results in decreased expression of PLEKHD1 mRNA

NCBI chr 6:100,340,655...100,371,942
Ensembl chr 6:100,340,655...100,371,941

G

perilipin 1

increases expression

Malathion results in increased expression of PLIN1 mRNA

NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828

G

perilipin 2

increases expression

Malathion results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

proteolipid protein 1

decreases expression

Malathion results in decreased expression of PLP1 mRNA

NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032

G

plastin 3

increases expression

Malathion results in increased expression of PLS3 mRNA

NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891

G

plasmalemma vesicle associated protein

decreases expression

Malathion results in decreased expression of PLVAP mRNA

NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301

G

PML nuclear body scaffold

decreases expression

Malathion results in decreased expression of PML mRNA

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

peroxisome proliferator activated receptor alpha

decreases expression

Malathion results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

protein kinase D1

increases expression

Malathion results in increased expression of PRKD1 mRNA

NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042

G

prospero homeobox 2

decreases expression

Malathion results in decreased expression of PROX2 mRNA