thiomalic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thiomalic acid	go back to main search page
Accession:	CHEBI:38705	browse the term
Definition:	A C4-dicarboxylic acid that has formula C4H6O4S.
Synonyms:	exact_synonym:	2-sulfanylbutanedioic acid
	related_synonym:	2-mercaptosuccinic acid; 2-sulfanylsuccinic acid; 2-thiomalic acid; Formula=C4H6O4S; InChI=1S/C4H6O4S/c5-3(6)1-2(9)4(7)8/h2,9H,1H2,(H,5,6)(H,7,8); InChIKey=NJRXVEJTAYWCQJ-UHFFFAOYSA-N; SMILES=OC(=O)CC(S)C(O)=O; alpha-mercaptosuccinic acid; mercaptosuccinic acid; monomercaptosuccinic acid
	xref:	Beilstein:1099858; CAS:70-49-5; Gmelin:218084
	xref_mesh:	MESH:C046062
	cyclic_relationship:	is_conjugate_acid_of CHEBI:38708

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Genes (456)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endonuclease G

multiple interactions

EXP

[Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

glutathione peroxidase 1

decreases activity

ISO

2-thiomalic acid results in decreased activity of GPX1 protein

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

tumor necrosis factor

multiple interactions

ISO

2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA binding domain containing 5

increases expression

ISO

Malathion results in increased expression of ACBD5 mRNA

NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286

G

acetylcholinesterase

multiple interactions
decreases activity

ISO
EXP

[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]
[Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]

PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

acyl-CoA thioesterase 6

decreases expression

ISO

Malathion results in decreased expression of ACOT6 mRNA

NCBI chr 6:103,732,372...103,741,446

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

ISO

Malathion results in decreased expression of ACSM1 mRNA

NCBI chr 1:183,417,052...183,451,897
Ensembl chr 1:183,416,009...183,454,217

G

ADAM metallopeptidase domain 11

increases methylation

ISO

Malathion results in increased methylation of ADAM11 promoter

NCBI chr10:88,224,185...88,242,865
Ensembl chr10:88,224,347...88,242,864

G

ADAM metallopeptidase domain 32

decreases expression

ISO

Malathion results in decreased expression of ADAM32 mRNA

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:73,805,052...73,914,785

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

ISO

Malathion results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:61,759,987...62,054,716

G

ADAM metallopeptidase with thrombospondin type 1 motif, 20

decreases expression

ISO

Malathion results in decreased expression of ADAMTS20 mRNA

NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:127,275,538...127,407,296

G

ADAM metallopeptidase with thrombospondin type 1 motif, 6

increases expression

ISO

Malathion results in increased expression of ADAMTS6 mRNA

NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:37,155,288...37,367,070

G

adducin 3

increases expression

EXP

Malathion results in increased expression of ADD3 mRNA

NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:262,154,996...262,260,504

G

adrenomedullin

increases expression

ISO

Malathion results in increased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

adrenoceptor alpha 2A

increases expression

ISO

Malathion results in increased expression of ADRA2A mRNA

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

ALF transcription elongation factor 1

increases expression

ISO

Malathion results in increased expression of AFF1 mRNA mutant form

NCBI chr14:6,165,864...6,328,848
Ensembl chr14:6,169,562...6,328,879

G

aryl hydrocarbon receptor

multiple interactions

ISO

[prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C1

increases expression

ISO

Malathion results in increased expression of AKR1C1 mRNA

PMID:16079077 PMID:18214805

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C2

increases expression

ISO

Malathion results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldo-keto reductase family 1, member E2

decreases expression

ISO

Malathion results in decreased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:70,645,869...70,660,360

G

ALK and LTK ligand 2

increases expression

ISO

Malathion results in increased expression of ALKAL2 mRNA

NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:53,223,341...53,233,011

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

EXP

Malathion results in increased activity of ALPL protein
thymoquinone inhibits the reaction [Malathion results in increased activity of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

angiomotin

decreases expression

ISO

Malathion results in decreased expression of AMOT mRNA

NCBI chr X:113,778,990...113,837,846
Ensembl chr X:113,781,526...113,837,482

G

angiopoietin-like 2

decreases expression

ISO

Malathion results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:36,914,745...36,945,876

G

angiopoietin-like 4

decreases methylation
increases expression

ISO

Malathion results in decreased methylation of ANGPTL4 promoter
Malathion results in increased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

ankyrin 1

decreases expression

ISO

Malathion results in decreased expression of ANK1 mRNA

NCBI chr16:75,578,824...75,757,464
Ensembl chr16:75,578,824...75,757,464

G

ankyrin repeat domain 55

increases expression

ISO

Malathion results in increased expression of ANKRD55 mRNA

NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:45,617,177...45,717,057

G

aprataxin and PNKP like factor

decreases expression

ISO

Malathion results in decreased expression of APLF mRNA

NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:121,627,800...121,679,961

G

aquaporin 12A

decreases expression

ISO

Malathion results in decreased expression of AQP12A mRNA

NCBI chr 9:93,554,527...93,560,011
Ensembl chr 9:101,001,939...101,007,425

G

aquaporin 9

increases expression

ISO

Malathion results in increased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

androgen receptor

multiple interactions
decreases expression

ISO
EXP

[terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein
Malathion results in decreased expression of AR mRNA

PMID:23871939 PMID:36336997

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

armadillo repeat containing 3

decreases expression

ISO

Malathion results in decreased expression of ARMC3 mRNA

NCBI chr17:81,814,087...81,917,534
Ensembl chr17:86,722,441...86,825,899

G

aryl hydrocarbon receptor nuclear translocator 2

decreases expression

ISO

Malathion results in decreased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:147,599,058...147,801,997

G

acid sensing ion channel subunit family member 5

increases expression

ISO

Malathion results in increased expression of ASIC5 mRNA

NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:169,606,059...169,634,885

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

ISO

Malathion results in decreased expression of ATP2B3 mRNA

NCBI chr X:156,367,582...156,464,085
Ensembl chr X:156,367,852...156,438,153

G

beta-1,4-galactosyltransferase 1

decreases expression

ISO

Malathion results in decreased expression of B4GALT1 mRNA

NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445

G

B9 domain containing 1

decreases expression

ISO

Malathion results in decreased expression of B9D1 mRNA

NCBI chr10:46,685,410...46,698,580
Ensembl chr10:46,686,133...46,695,428

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions
increases expression

EXP
ISO

Malathion results in decreased expression of BAX mRNA
Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin inhibits the reaction [Malathion results in increased expression of BAX protein]

PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

multiple interactions
decreases activity
increases activity

ISO
EXP

Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]
Malathion results in increased activity of BCHE protein

PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
increases expression

EXP
ISO

Malathion results in decreased expression of BCL2 mRNA
Malathion results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
Malathion results in increased expression of BCL2 protein
Malathion results in increased expression of BCL2 mRNA

PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

multiple interactions

ISO

[Pesticides results in increased abundance of Malathion metabolite] which results in decreased secretion of BDNF protein; [Pesticides results in increased abundance of Malathion metabolite] which results in increased methylation of BDNF gene

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

EXP

Malathion results in increased expression of BIRC5 protein
Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of BIRC5 protein]; thymoquinone inhibits the reaction [Malathion results in increased expression of BIRC5 protein]

PMID:33510276 PMID:34262720

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BMI1 proto-oncogene, polycomb ring finger

increases expression

ISO

Malathion results in increased expression of BMI1 mRNA

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024

G

bromodomain containing 7

increases expression

ISO

Malathion results in increased expression of BRD7 mRNA

NCBI chr19:34,882,238...34,910,944
Ensembl chr19:34,882,304...34,910,944

G

barttin CLCNK type accessory subunit beta

increases expression

ISO

Malathion results in increased expression of BSND mRNA

NCBI chr 5:126,480,590...126,489,389
Ensembl chr 5:126,480,592...126,489,389

G

BTG anti-proliferation factor 1

decreases expression

ISO

Malathion results in decreased expression of BTG1 mRNA

NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

ISO

Malathion results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

similar to human chromosome 10 open reading frame 53

decreases expression

ISO

Malathion results in decreased expression of C10ORF53 mRNA

NCBI chr16:7,640,521...7,651,190
Ensembl chr16:7,640,521...7,651,190

G

complement C1q like 2

decreases expression

ISO

Malathion results in decreased expression of C1QL2 mRNA

NCBI chr13:34,023,902...34,025,437
Ensembl chr13:34,023,177...34,026,020

G

similar to human chromosome 3 open reading frame 80

decreases expression

ISO

Malathion results in decreased expression of C3ORF80 mRNA

NCBI chr 2:153,125,312...153,128,124
Ensembl chr 2:155,434,073...155,437,507

G

similar to human chromosome 11 open reading frame 96

increases expression

ISO

Malathion results in increased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:100,351,199...100,378,346

G

similar to human chromosome 15 open reading frame 48

increases expression

ISO

Malathion results in increased expression of C15ORF48 mRNA

NCBI chr 3:130,173,535...130,177,088
Ensembl chr 3:130,173,416...130,177,089

G

similar to human chromosome 8 open reading frame 34

decreases expression

ISO

Malathion results in decreased expression of C8ORF34 mRNA

NCBI chr 5:7,237,968...7,777,119
Ensembl chr 5:12,021,007...12,559,772

G

similar to human chromosome 12 open reading frame 54

decreases expression

ISO

Malathion results in decreased expression of C12ORF54 mRNA

NCBI chr 7:129,529,811...129,548,676

G

calcium binding protein 7

decreases expression

ISO

Malathion results in decreased expression of CABP7 mRNA

NCBI chr14:79,598,822...79,609,172
Ensembl chr14:83,822,327...83,832,735

G

calcium voltage-gated channel subunit alpha1 C

increases expression

ISO

Malathion results in increased expression of CACNA1C mRNA

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

EXP

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

multiple interactions

EXP

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calpain 8

decreases expression

ISO

Malathion results in decreased expression of CAPN8 mRNA

NCBI chr13:94,252,218...94,316,146
Ensembl chr13:96,783,667...96,847,820

G

CART prepropeptide

increases expression

ISO

Malathion results in increased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712

G

caspase 3

increases activity
multiple interactions
increases expression
increases cleavage

ISO
EXP

Malathion results in increased activity of CASP3 protein
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]

PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

decreases expression

ISO

Malathion results in decreased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

increases activity

ISO

Malathion results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity
increases expression
multiple interactions
increases cleavage

ISO
EXP

Malathion results in increased activity of CASP9 protein
Malathion results in increased expression of CASP9 mRNA
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]

PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity
increases activity
decreases expression

EXP
ISO

[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
[Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]

PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

core-binding factor subunit beta

increases expression

ISO

Malathion results in increased expression of CBFB mRNA

NCBI chr19:49,955,133...50,002,661
Ensembl chr19:49,959,096...50,002,657

G

coiled-coil domain containing 126

increases expression

ISO

Malathion results in increased expression of CCDC126 mRNA

NCBI chr 4:79,628,483...79,649,513
Ensembl chr 4:79,628,412...79,649,508

G

cholecystokinin

increases expression

EXP

Malathion results in increased expression of CCK mRNA

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686

G

C-C motif chemokine ligand 1

increases expression

ISO

Malathion results in increased expression of CCL1 mRNA

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790

G

C-C motif chemokine ligand 19

increases expression

ISO

Malathion results in increased expression of CCL19 mRNA

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022

G

C-C motif chemokine ligand 20

increases expression

ISO

Malathion results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

increases expression

ISO

Malathion results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 7

increases expression

ISO

Malathion results in increased expression of CCL7 mRNA

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

CCM2 like scaffold protein

increases expression

ISO

Malathion results in increased expression of CCM2L mRNA

NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:161,859,312...162,009,371

G

cyclin A2

decreases expression

ISO

Malathion results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

Malathion results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin E1

decreases expression

ISO

Malathion results in decreased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

coiled-coil serine-rich protein 1

increases expression

ISO

Malathion results in increased expression of CCSER1 mRNA

NCBI chr 4:91,483,896...92,720,439
Ensembl chr 4:91,483,770...92,718,789

G

CD14 molecule

decreases expression

ISO

Malathion results in decreased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD274 molecule

increases expression

ISO

Malathion results in increased expression of CD274 mRNA

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD36 molecule

increases expression

ISO

Malathion results in increased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

Cd5 molecule

decreases expression

ISO

Malathion results in decreased expression of CD5 mRNA

NCBI chr 1:216,790,245...216,811,209
Ensembl chr 1:216,790,245...216,811,209

G

Cd69 molecule

increases expression

ISO

Malathion results in increased expression of CD69 mRNA

NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:164,411,485...164,419,509

G

cell division cycle 20

decreases expression

ISO

Malathion results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cyclin-dependent kinase 15

increases expression

ISO

Malathion results in increased expression of CDK15 mRNA

NCBI chr 9:68,205,759...68,299,218
Ensembl chr 9:68,205,678...68,293,579

G

cyclin dependent kinase 2

decreases expression
increases expression

ISO

Malathion results in decreased expression of CDK2 protein
Malathion results in increased expression of CDK2 mRNA

PMID:30769050 PMID:32069766

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

CCAAT/enhancer binding protein gamma

increases expression

ISO

Malathion results in increased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

centromere protein F

decreases expression

ISO

Malathion results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:103,715,344...103,760,886

G

carboxylesterase 1D

increases expression

ISO

Malathion results in increased expression of CES1 mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cilia and flagella associated protein 157

decreases expression

ISO

Malathion results in decreased expression of CFAP157 mRNA

NCBI chr 3:16,066,521...16,073,504
Ensembl chr 3:36,464,219...36,471,193

G

cilia and flagella associated protein 91

decreases expression

ISO

Malathion results in decreased expression of CFAP91 mRNA

NCBI chr11:62,413,613...62,457,281
Ensembl chr11:75,919,142...75,962,785

G

complement factor B

increases expression

ISO

Malathion results in increased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

cholesterol 25-hydroxylase

increases expression

ISO

Malathion results in increased expression of CH25H mRNA

NCBI chr 1:241,428,048...241,429,366
Ensembl chr 1:241,331,619...241,431,190

G

claudin 12

increases expression

ISO

Malathion results in increased expression of CLDN12 mRNA

NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:29,477,342...29,493,776

G

claudin 22

decreases expression

ISO

Malathion results in decreased expression of CLDN22 mRNA

NCBI chr16:44,422,344...44,423,370

G

claudin 5

multiple interactions
decreases expression

EXP

[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein
Malathion results in decreased expression of CLDN5 protein

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

chymase 1

decreases expression

ISO

Malathion results in decreased expression of CMA1 mRNA

NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133

G

contactin 4

increases expression

ISO

Malathion results in increased expression of CNTN4 mRNA

NCBI chr 4:140,180,696...141,177,771
Ensembl chr 4:140,596,284...141,177,766

G

collagen type I alpha 2 chain

increases expression

ISO

Malathion results in increased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

copine family member 9

decreases expression

ISO

Malathion results in decreased expression of CPNE9 mRNA

NCBI chr 4:146,429,961...146,454,335
Ensembl chr 4:147,986,452...148,009,986

G

carboxypeptidase Z

decreases expression

ISO

Malathion results in decreased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:79,448,139...79,471,556

G

corticotropin releasing hormone

multiple interactions
decreases expression

EXP

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

PMID:20233601 PMID:25404496

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

cysteine-rich secretory protein 3

decreases expression

ISO

Malathion results in decreased expression of CRISP3 mRNA

NCBI chr 9:27,928,591...27,969,205
Ensembl chr 9:27,895,536...27,969,198

G

cysteine-rich secretory protein LCCL domain containing 2

decreases expression

EXP

Malathion results in decreased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:64,961,771...65,020,349

G

colony stimulating factor 2

increases expression

EXP
ISO

Malathion results in increased expression of CSF2 protein
Malathion results in increased expression of CSF2 mRNA

PMID:34778934 PMID:37047231

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

increases expression

ISO

Malathion results in increased expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cathepsin D

increases expression

ISO

Malathion results in increased expression of CTSD protein

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

C-X-C motif chemokine ligand 11

increases expression

ISO

Malathion results in increased expression of CXCL11 mRNA

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567

G

cytochrome b-245 beta chain

multiple interactions
increases expression

ISO

Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

chymosin

decreases expression

ISO

Malathion results in decreased expression of CYMP mRNA

NCBI chr 2:197,516,947...197,527,307
Ensembl chr 2:197,516,950...197,527,837

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

ISO

Malathion results in decreased expression of CYP11A1 mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

EXP

[bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases expression

ISO

CYP1A2 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP1A2 mRNA

PMID:15557345 PMID:22310298

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

ISO

Malathion results in increased expression of CYP27B1 mRNA

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects metabolic processing
decreases activity
increases expression
multiple interactions

ISO

CYP2B6 protein affects the metabolism of Malathion
Malathion results in decreased activity of CYP2B6 protein
Malathion results in increased expression of CYP2B6 mRNA
Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]

PMID:15557345 PMID:22310298 PMID:24333466

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

ISO

Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Malathion results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing
increases expression

ISO

[Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A4 mRNA

PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing
increases expression

ISO

CYP3A5 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A5 mRNA

PMID:17110060 PMID:37047231

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

ISO

[Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

decorin

increases expression

ISO

Malathion results in increased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

dopa decarboxylase

affects binding
increases expression

ISO

Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein
Malathion results in increased expression of DDC mRNA

PMID:35151785 PMID:37047231

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

discoidin domain receptor tyrosine kinase 1

decreases expression

ISO

Malathion results in decreased expression of DDR1 mRNA

NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276

G

DEAD/H-box helicase 11

increases expression

ISO

Malathion results in increased expression of DDX11 mRNA

NCBI chr 9:113,204,886...113,309,692
Ensembl chr 9:113,276,985...113,316,152

G

iodothyronine deiodinase 1

decreases expression

ISO

Malathion results in decreased expression of DIO1 mRNA

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

DISC1 scaffold protein

increases expression

ISO

Malathion results in increased expression of DISC1 mRNA

NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970

G

dickkopf WNT signaling pathway inhibitor 2

increases expression

ISO

Malathion results in increased expression of DKK2 mRNA

NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:223,242,377...223,334,724

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Malathion results in increased expression of DLG2 mRNA

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

DNA methyltransferase 1

decreases expression

EXP

Malathion results in decreased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

affects expression

EXP

Malathion affects the expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

DNA methyltransferase 3 beta

affects expression

EXP

Malathion affects the expression of DNMT3B mRNA

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

double C2 domain beta

decreases expression

ISO

Malathion results in decreased expression of DOC2B mRNA

NCBI chr10:61,126,295...61,151,533
Ensembl chr10:61,126,295...61,151,533

G

desmoplakin

increases expression

ISO

Malathion results in increased expression of DSP mRNA

NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121

G

dentin sialophosphoprotein

decreases expression

ISO

Malathion results in decreased expression of DSPP mRNA

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

dystrobrevin, alpha

decreases expression

ISO

Malathion results in decreased expression of DTNA mRNA

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,862,818...15,218,993

G

dual oxidase 1

multiple interactions
increases expression

ISO

Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein]

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:129,714,149...129,749,187

G

dual specificity phosphatase 1

decreases expression

ISO

Malathion results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 5

increases expression

ISO

Malathion results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dishevelled segment polarity protein 1

increases expression

ISO

Malathion results in increased expression of DVL1 mRNA

NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966

G

Epstein-Barr virus induced 3

increases expression

ISO

Malathion results in increased expression of EBI3 mRNA

NCBI chr 9:861,441...874,731
Ensembl chr 9:870,792...874,973

G

endothelin 1

increases expression

ISO

Malathion results in increased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type B

decreases expression

ISO

Malathion results in decreased expression of EDNRB mRNA

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

EF-hand calcium binding domain 9

increases expression

ISO

Malathion results in increased expression of EFCAB9 mRNA

NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,611,022...17,616,566

G

EH domain binding protein 1

increases response to substance

ISO

EHBP1 gene SNP results in increased susceptibility to Malathion

NCBI chr14:100,294,585...100,581,764
Ensembl chr14:100,294,585...100,546,579

G

engrailed homeobox 1

decreases expression

ISO

Malathion results in decreased expression of EN1 mRNA

NCBI chr13:34,303,684...34,309,269
Ensembl chr13:34,303,702...34,309,269

G

enkurin, TRPC channel interacting protein

increases expression

ISO

Malathion results in increased expression of ENKUR mRNA

NCBI chr17:88,599,057...88,622,668
Ensembl chr17:88,599,057...88,622,668

G

EPH receptor A10

increases expression

ISO

Malathion results in increased expression of EPHA10 mRNA

NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:142,424,296...142,460,305

G

Eph receptor A4

increases expression

ISO

Malathion results in increased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

epoxide hydrolase 1

decreases expression

ISO

Malathion results in decreased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

elongin BC and polycomb repressive complex 2 associated protein

increases expression

ISO

Malathion results in increased expression of EPOP mRNA

NCBI chr10:83,120,767...83,122,287
Ensembl chr10:83,119,970...83,122,423

G

EPS8 signaling adaptor L1

increases expression

ISO

Malathion results in increased expression of EPS8L1 mRNA

NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:78,386,916...78,406,187

G

erb-b2 receptor tyrosine kinase 4

increases expression

ISO

Malathion results in increased expression of ERBB4 mRNA

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772

G

estrogen receptor 1

decreases activity

ISO

Malathion results in decreased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

ETS variant transcription factor 6

increases expression

ISO

Malathion results in increased expression of ETV6 mRNA mutant form

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802

G

coagulation factor III, tissue factor

increases expression

ISO

Malathion results in increased expression of F3 mRNA

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

family with sequence similarity 124 member A

increases expression

ISO

Malathion results in increased expression of FAM124A mRNA

NCBI chr15:36,799,836...36,855,062
Ensembl chr15:40,975,877...41,029,628

G

family with sequence similarity 227, member B

decreases expression

ISO

Malathion results in decreased expression of FAM227B mRNA

NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:133,686,605...133,845,717

G

family with sequence similarity 229, member B

decreases expression

ISO

Malathion results in decreased expression of FAM229B mRNA

NCBI chr20:42,538,853...42,552,355
Ensembl chr20:44,093,493...44,106,871

G

fibroblast growth factor 22

decreases expression

ISO

Malathion results in decreased expression of FGF22 mRNA

NCBI chr 7:10,598,254...10,600,945
Ensembl chr 7:10,597,538...10,600,945

G

fibroblast growth factor 6

increases expression

ISO

Malathion results in increased expression of FGF6 mRNA

NCBI chr 4:161,541,089...161,549,624
Ensembl chr 4:161,541,089...161,553,521

G

fibroblast growth factor binding protein 1

increases expression

ISO

Malathion results in increased expression of FGFBP1 mRNA

NCBI chr14:71,316,171...71,319,965
Ensembl chr14:71,317,065...71,320,309

G

Fibroblast growth factor receptor 1

increases expression

ISO

Malathion results in increased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

fibrinogen gamma chain

decreases expression

ISO

Malathion results in decreased expression of FGG mRNA

NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170

G

filamin A interacting protein 1-like

increases expression

ISO

Malathion results in increased expression of FILIP1L mRNA

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:56,410,582...56,646,402

G

Fms related receptor tyrosine kinase 4

increases expression

ISO

Malathion results in increased expression of FLT4 mRNA

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645

G

forkhead box O1

decreases expression
multiple interactions
increases methylation

EXP

Malathion results in decreased expression of FOXO1 mRNA
[Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O4

increases expression

ISO

Malathion results in increased expression of FOXO4 mRNA

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:70,425,563...70,432,120

G

follicle stimulating hormone receptor

increases expression

ISO

Malathion results in increased expression of FSHR mRNA

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

glucose-6-phosphate dehydrogenase

multiple interactions
increases activity

EXP

[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
Malathion results in increased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutamate decarboxylase 1

affects binding

ISO

Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

glutamate decarboxylase 2

affects binding

ISO

Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

polypeptide N-acetylgalactosaminyltransferase 16

increases expression

ISO

Malathion results in increased expression of GALNT16 mRNA

NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:105,901,153...105,991,350

G

golgi associated RAB2 interactor family member 2

decreases expression

ISO

Malathion results in decreased expression of GARIN2 mRNA

NCBI chr 6:97,489,562...97,534,729
Ensembl chr 6:103,223,365...103,267,819

G

growth arrest-specific 2

increases expression

ISO

Malathion results in increased expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:110,717,312...110,718,541

G

GATA binding protein 4

decreases expression

ISO

Malathion results in decreased expression of GATA4 mRNA

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

guanylate binding protein 1

increases expression

ISO

Malathion results in increased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

guanylate binding protein 3

increases expression

ISO

Malathion results in increased expression of GBP3 mRNA

NCBI chr 2:234,144,042...234,173,527
Ensembl chr 2:234,146,519...234,180,055

G

guanylate binding protein 5

increases expression

ISO

Malathion results in increased expression of GBP5 mRNA

NCBI chr 2:233,910,999...233,930,320
Ensembl chr 2:233,902,113...233,930,826

G

glycerol kinase

multiple interactions
increases activity

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

glycerol kinase 2

decreases expression

EXP

Malathion results in decreased expression of GK2 mRNA

NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,411,071...12,414,592

G

geminin coiled-coil domain containing

increases expression

ISO

Malathion results in increased expression of GMNC mRNA

NCBI chr11:73,836,255...73,847,698
Ensembl chr11:87,341,446...87,352,151

G

G protein subunit alpha i1

increases expression

ISO

Malathion results in increased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

decreases expression

ISO

Malathion results in decreased expression of GNAI2 mRNA

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases activity

EXP

thymoquinone inhibits the reaction [Malathion results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic-oxaloacetic transaminase 1-like 1

increases expression

ISO

Malathion results in increased expression of GOT1L1 mRNA

NCBI chr16:71,563,562...71,576,446
Ensembl chr16:71,563,534...71,570,468

G

glycoprotein V (platelet)

increases expression

ISO

Malathion results in increased expression of GP5 mRNA

NCBI chr11:83,948,507...83,952,362
Ensembl chr11:83,948,507...83,952,367

G

G protein-coupled receptor 179

decreases expression

ISO

Malathion results in decreased expression of GPR179 mRNA

NCBI chr10:82,820,954...82,836,833
Ensembl chr10:82,821,113...82,836,833

G

G protein pathway suppressor 2

decreases expression

ISO

Malathion results in decreased expression of GPS2 mRNA

NCBI chr10:55,136,043...55,139,106
Ensembl chr10:55,136,169...55,139,862

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

EXP

Malathion results in increased activity of GPT protein
thymoquinone inhibits the reaction [Malathion results in increased activity of GPT protein]

PMID:25180440 PMID:33510276 PMID:36370973

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

GRAM domain containing 4

decreases expression

ISO

Malathion results in decreased expression of GRAMD4 mRNA

NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:119,030,225...119,103,875

G

G protein-coupled receptor kinase 1

increases expression

ISO

Malathion results in increased expression of GRK1 mRNA

NCBI chr16:82,821,184...82,837,971
Ensembl chr16:82,826,022...82,837,971

G

glycogen synthase kinase 3 beta

increases expression

EXP

Malathion results in increased expression of GSK3B mRNA

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

multiple interactions
decreases activity

ISO
EXP

[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein
Malathion results in decreased activity of GSR protein
zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]

PMID:16718366 PMID:19429256

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase pi 1

decreases expression

ISO

Malathion results in decreased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

granzyme B

decreases expression
multiple interactions

ISO

Malathion results in decreased expression of GZMB protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]

NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469

G

H19 imprinted maternally expressed transcript

increases expression

ISO

Malathion results in increased expression of H19 mRNA

NCBI chr 1:207,160,175...207,162,851

G

hyaluronan synthase 1

increases expression

ISO

Malathion results in increased expression of HAS1 mRNA

NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444

G

heparin-binding EGF-like growth factor

increases expression

ISO

Malathion results in increased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

histidine decarboxylase

affects binding

ISO

Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

hypoxia inducible lipid droplet-associated

increases expression

ISO

Malathion results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:58,836,463...58,839,423

G

heme oxygenase 1

increases expression

EXP

Malathion results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

histamine N-methyltransferase

decreases expression

ISO

Malathion results in decreased expression of HNMT mRNA

NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482

G

HRas proto-oncogene, GTPase

multiple interactions
increases expression

ISO

[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA
Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein

PMID:18204794 PMID:19787260

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

ISO
EXP

lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA]

PMID:30409133 PMID:36336997

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

heat shock transcription factor 2 binding protein

increases expression

ISO

Malathion results in increased expression of HSF2BP mRNA

NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,263...10,121,826

G

heat shock protein family B (small) member 2

increases expression

ISO

Malathion results in increased expression of HSPB2 protein

NCBI chr 8:59,989,640...59,991,215
Ensembl chr 8:59,976,623...59,990,901

G

HIV-1 Tat interactive protein 2

decreases expression

ISO

Malathion results in decreased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815

G

HtrA serine peptidase 4

decreases expression

ISO

Malathion results in decreased expression of HTRA4 mRNA

NCBI chr16:67,001,605...67,015,074
Ensembl chr16:73,704,184...73,717,722

G

indoleamine 2,3-dioxygenase 1

increases expression

ISO

Malathion results in increased expression of IDO1 mRNA

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

interferon-induced protein 44-like

increases expression

ISO

Malathion results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404

G

interferon beta 1

multiple interactions

ISO

Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

decreases expression
multiple interactions
increases expression

EXP
ISO

Malathion results in decreased expression of IFNG protein
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein]

PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 11

increases expression

ISO

Malathion results in increased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 13

increases expression

ISO

Malathion results in increased expression of IL13 mRNA

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 13 receptor subunit alpha 2

increases expression

ISO

Malathion results in increased expression of IL13RA2 mRNA

NCBI chr X:115,814,620...115,886,080
Ensembl chr X:115,814,622...115,841,455

G

interleukin 1 alpha

increases expression

ISO

Malathion results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

EXP
ISO

Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]
Malathion results in decreased expression of IL1B protein

PMID:24810974 PMID:25180440 PMID:28987951 PMID:32495713 PMID:37047231

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 2

decreases expression

EXP

Malathion results in decreased expression of IL1R2 mRNA

NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374

G

interleukin 2

multiple interactions
decreases expression

ISO

Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 23 subunit alpha

increases expression

ISO

Malathion results in increased expression of IL23A mRNA

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 24

increases expression

ISO

Malathion results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 36, gamma

increases expression

ISO

Malathion results in increased expression of IL36G mRNA

NCBI chr 3:27,346,675...27,352,839
Ensembl chr 3:27,346,670...27,352,834

G

interleukin 4

decreases expression
multiple interactions

ISO

Malathion results in decreased expression of IL4 protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
increases expression
decreases expression

EXP
ISO

Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]
Malathion results in decreased expression of IL6 protein

PMID:24810974 PMID:25180440 PMID:32495713 PMID:37047231

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit beta A

increases expression
decreases methylation

ISO

Malathion results in increased expression of INHBA mRNA
Malathion results in decreased methylation of INHBA promoter

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

insulin 1

increases expression

EXP

Malathion results in increased expression of INS1 protein

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

interleukin-1 receptor-associated kinase 1

increases expression

ISO

Malathion results in increased expression of IRAK1 mRNA

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 2

increases expression

ISO

Malathion results in increased expression of IRAK2 mRNA

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

iroquois homeobox 2

increases expression

ISO

Malathion results in increased expression of IRX2 mRNA

NCBI chr 1:32,489,512...32,494,930
Ensembl chr 1:32,489,512...32,494,930

G

integrin subunit beta 8

decreases methylation
increases expression

ISO

Malathion results in decreased methylation of ITGB8 promoter
Malathion results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:146,165,484...146,351,245

G

kazrin, periplakin interacting protein

decreases expression

ISO

Malathion results in decreased expression of KAZN mRNA

NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:159,675,803...160,664,154

G

potassium voltage-gated channel subfamily H member 5

increases expression

ISO

Malathion results in increased expression of KCNH5 mRNA

NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:99,360,302...99,643,856

G

potassium calcium-activated channel subfamily M alpha 1

increases methylation
decreases expression

ISO

Malathion results in increased methylation of KCNMA1 promoter
Malathion results in decreased expression of KCNMA1 mRNA

NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117

G

kinesin family member 6

decreases expression

ISO

Malathion results in decreased expression of KIF6 mRNA

NCBI chr 9:18,573,925...18,870,789
Ensembl chr 9:18,573,789...18,870,729

G

KIT proto-oncogene receptor tyrosine kinase

increases expression
multiple interactions

EXP

Malathion results in increased expression of KIT protein
Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of KIT protein]; thymoquinone inhibits the reaction [Malathion results in increased expression of KIT protein]

PMID:33510276 PMID:34262720

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

lysine methyltransferase 2A

increases mutagenesis
increases expression

ISO

Malathion results in increased mutagenesis of KMT2A gene
Malathion results in increased expression of KMT2A mRNA mutant form

NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317

G

keratin 14

increases expression

ISO

Malathion results in increased expression of KRT14 mRNA

NCBI chr10:85,638,182...85,642,450

G

keratin 17

increases expression

ISO

Malathion results in increased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,679,070...85,683,787

G

keratin associated protein 27-1

increases expression

ISO

Malathion results in increased expression of KRTAP27-1 mRNA

NCBI chr11:27,980,875...27,982,002

G

LINE-1 type transposase domain containing 1

affects expression
increases methylation
multiple interactions

EXP

Malathion affects the expression of L1TD1 mRNA
Malathion results in increased methylation of L1TD1 promoter
[Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA

NCBI chr 5:113,373,193...113,386,088
Ensembl chr 5:118,488,688...118,501,591

G

linker for activation of T cells

increases expression

EXP

Malathion results in increased expression of LAT mRNA

NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:190,367,109...190,372,153

G

ligand dependent nuclear receptor corepressor-like

increases expression

ISO

Malathion results in increased expression of LCORL mRNA

NCBI chr14:65,271,339...65,407,732
Ensembl chr14:69,518,837...69,587,177

G

LEM domain containing 1

increases expression

ISO

Malathion results in increased expression of LEMD1 mRNA

NCBI chr13:46,183,860...46,250,105
Ensembl chr13:46,218,085...46,250,562

G

galectin 1

decreases expression

ISO

Malathion results in decreased expression of LGALS1 mRNA

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800

G

LIF, interleukin 6 family cytokine

increases expression

ISO

Malathion results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

lin-28 homolog B

increases expression

ISO

Malathion results in increased expression of LIN28B mRNA

NCBI chr20:50,447,700...50,547,135
Ensembl chr20:50,450,971...50,541,968

G

leucine rich repeat and Ig domain containing 1

decreases expression

ISO

Malathion results in decreased expression of LINGO1 mRNA

NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:65,897,844...66,091,740

G

limb development membrane protein 1

increases expression

ISO

Malathion results in increased expression of LMBR1 mRNA

NCBI chr 4:6,649,824...6,820,525
Ensembl chr 4:6,649,821...6,822,238

G

mucin-12-like

decreases expression

ISO

Malathion results in decreased expression of MUC12 mRNA

NCBI chr12:19,486,041...19,493,995

G

lysophosphatidylcholine acyltransferase 4

increases expression

ISO

Malathion results in increased expression of LPCAT4 mRNA

NCBI chr 3:119,499,128...119,507,275
Ensembl chr 3:119,499,128...119,507,362

G

leucine-rich repeats and guanylate kinase domain containing

decreases expression

ISO

Malathion results in decreased expression of LRGUK mRNA

NCBI chr 4:62,647,222...62,770,268
Ensembl chr 4:63,614,461...63,763,564

G

LDL receptor related protein 3

decreases expression

ISO

Malathion results in decreased expression of LRP3 mRNA

NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:96,981,815...96,996,057

G

Ly6/Plaur domain containing 1

decreases expression

ISO

Malathion results in decreased expression of LYPD1 mRNA

NCBI chr13:39,874,937...39,922,385
Ensembl chr13:39,879,096...39,922,338

G

leucine zipper tumor suppressor 1

increases expression

ISO

Malathion results in increased expression of LZTS1 mRNA

NCBI chr16:25,309,502...25,364,942
Ensembl chr16:25,309,507...25,364,940

G

leucine zipper tumor suppressor 2

decreases expression

ISO

Malathion results in decreased expression of LZTS2 mRNA

NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:253,829,119...253,837,632

G

mono-ADP ribosylhydrolase 2

decreases expression

ISO

Malathion results in decreased expression of MACROD2 mRNA

NCBI chr 3:148,173,821...150,191,077
Ensembl chr 3:148,173,829...150,188,058

G

mitogen activated protein kinase kinase 3

decreases expression

ISO

Malathion results in decreased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

membrane associated ring-CH-type finger 3

increases expression

ISO

Malathion results in increased expression of MARCHF3 mRNA

NCBI chr18:52,435,292...52,587,321
Ensembl chr18:52,435,296...52,587,297

G

myelin basic protein

decreases expression

ISO

Malathion results in decreased expression of MBP mRNA

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

minichromosome maintenance complex component 2

multiple interactions
increases expression

ISO

[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA
Malathion results in increased expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094

G

Meis homeobox 1

decreases expression

ISO

Malathion results in decreased expression of MEIS1 mRNA

NCBI chr14:93,155,426...93,294,373
Ensembl chr14:97,322,748...97,495,083

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Malathion results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

ISO

Malathion results in increased expression of MFSD2A mRNA

NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916

G

MHC I like leukocyte 1

increases expression

ISO

Malathion results in increased expression of MICA mRNA

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:87,500,676...87,526,981

G

matrix metallopeptidase 1

increases expression

ISO

Malathion results in increased expression of MMP1 mRNA

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 10

increases expression

ISO

Malathion results in increased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

matrix metallopeptidase 12

increases expression

ISO

Malathion results in increased expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 3

increases expression

ISO

Malathion results in increased expression of MMP3 mRNA

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

myeloperoxidase

multiple interactions
increases activity

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein]

PMID:24810974 PMID:25180440

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

ISO

Malathion results in decreased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded cytochrome c oxidase III

decreases expression

ISO

Malathion results in decreased expression of COX3 mRNA

NCBI chr MT:8,599...9,382
Ensembl chr MT:8,584...9,367

G

metallothionein 1, pseudogene 3

increases expression

ISO

Malathion results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 2

increases expression

ISO

Malathion results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

myosin binding protein H-like

increases expression

ISO

Malathion results in increased expression of MYBPHL mRNA

NCBI chr 2:198,692,857...198,706,953
Ensembl chr 2:198,693,101...198,705,738

G

myosin Ib

increases expression

ISO

Malathion results in increased expression of MYO1B mRNA

NCBI chr 9:57,182,059...57,344,335
Ensembl chr 9:57,181,987...57,344,328

G

myocardial zonula adherens protein

increases expression

ISO

Malathion results in increased expression of MYZAP mRNA

NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:81,036,601...81,123,810

G

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

ISO

Malathion results in decreased expression of NDUFS7 mRNA

NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:10,103,227...10,110,691

G

neurofilament heavy chain

affects expression
increases expression

EXP

Malathion affects the expression of NEFH mRNA
Malathion results in increased expression of NEFH mRNA

PMID:22954530 PMID:28385489

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NIMA-related kinase 10

decreases expression

ISO

Malathion results in decreased expression of NEK10 mRNA

NCBI chr15:10,387,063...10,564,177
Ensembl chr15:12,813,606...13,013,567

G

neuraminidase 4

increases expression

ISO

Malathion results in increased expression of NEU4 mRNA

NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:101,844,261...101,849,917

G

neuralized E3 ubiquitin protein ligase 3

increases expression

ISO

Malathion results in increased expression of NEURL3 mRNA

NCBI chr 9:45,990,373...45,998,470
Ensembl chr 9:45,990,375...45,998,535

G

NFE2 like bZIP transcription factor 2

increases activity

ISO

Malathion results in increased activity of NFE2L2 protein

PMID:30114225 PMID:30203046

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor I/B

decreases expression

ISO

Malathion results in decreased expression of NFIB mRNA

NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:101,805,168...102,019,945

G

nerve growth factor

multiple interactions

EXP

Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

ninjurin 1

decreases expression

ISO

Malathion results in decreased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

nicotinamide nucleotide transhydrogenase

decreases expression

ISO

Malathion results in decreased expression of NNT mRNA

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310

G

nitric oxide synthase 2

increases expression

EXP

Malathion results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

Malathion results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity

ISO

Malathion results in increased expression of NR1I3 mRNA
Malathion results in increased activity of NR1I3 protein

PMID:22310298 PMID:28927721 PMID:30203046

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 4, group A, member 1

increases expression

ISO

Malathion results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 3

decreases methylation
increases expression

ISO

Malathion results in decreased methylation of NR4A3 promoter
Malathion results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

netrin 1

increases expression

ISO

Malathion results in increased expression of NTN1 mRNA

NCBI chr10:53,398,852...53,597,595
Ensembl chr10:53,398,852...53,584,060

G

neurotrophic receptor tyrosine kinase 2

increases expression

ISO

Malathion results in increased expression of NTRK2 mRNA

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

occludin

multiple interactions
decreases expression

EXP

[Malathion co-treated with Lead] results in decreased expression of OCLN protein
Malathion results in decreased expression of OCLN protein

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

osteoclast stimulatory transmembrane protein

increases expression

ISO

Malathion results in increased expression of OCSTAMP mRNA

NCBI chr 3:174,550,420...174,560,907
Ensembl chr 3:174,550,935...174,556,289

G

odontogenic, ameloblast associated

decreases expression

ISO

Malathion results in decreased expression of ODAM mRNA

NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,472,546...20,481,760

G

outer dense fiber of sperm tails 2-like

decreases expression

ISO

Malathion results in decreased expression of ODF2L mRNA

NCBI chr 2:236,696,158...236,733,090
Ensembl chr 2:236,696,389...236,733,086

G

olfactory receptor 1433

increases expression

ISO

Malathion results in increased expression of OR2W3 mRNA

NCBI chr10:43,042,427...43,046,293

G

olfactory receptor 1523

decreases expression

ISO

Malathion results in decreased expression of OR4D1 mRNA

NCBI chr10:72,708,272...72,709,213

G

olfactory receptor 35

decreases expression

ISO

Malathion results in decreased expression of OR2AT4 mRNA

NCBI chr 1:153,994,678...154,043,281
Ensembl chr 1:163,453,423...163,455,377

G

oligodendrocyte-myelin glycoprotein

affects expression

ISO

Malathion affects the expression of OMG mRNA

NCBI chr10:64,959,316...64,962,050
Ensembl chr10:64,936,145...64,962,050

G

opsin 5

decreases expression

ISO

Malathion results in decreased expression of OPN5 mRNA

NCBI chr 9:25,865,610...25,913,315
Ensembl chr 9:25,865,610...25,913,315

G

olfactory receptor family 4 subfamily F member 7C

decreases expression

ISO

Malathion results in decreased expression of OR4F21 mRNA

NCBI chr 3:98,458,889...98,459,827
Ensembl chr 3:118,913,402...118,914,340

G

olfactory receptor family 6 subfamily C member 2

decreases expression

ISO

Malathion results in decreased expression of OR6C2 mRNA

NCBI chr 7:2,188,601...2,189,539
Ensembl chr 7:2,817,089...2,818,027

G

olfactory receptor family 9 subfamily G member 4

decreases expression

ISO

Malathion results in decreased expression of OR9G4 mRNA

NCBI chr 3:70,727,963...70,728,901
Ensembl chr 3:91,134,643...91,135,581

G

purinergic receptor P2X 1

increases expression

EXP

Malathion results in increased expression of P2RX1 mRNA

NCBI chr10:58,117,107...58,132,167
Ensembl chr10:58,117,088...58,132,164

G

palmdelphin

decreases expression

ISO

Malathion results in decreased expression of PALMD mRNA

NCBI chr 2:207,574,413...207,626,239
Ensembl chr 2:207,574,249...207,626,239

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

Malathion results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

paired box 1

increases expression

ISO

Malathion results in increased expression of PAX1 mRNA

NCBI chr 3:155,244,961...155,254,836
Ensembl chr 3:155,245,529...155,254,836

G

protocadherin related 15

decreases expression

ISO

Malathion results in decreased expression of PCDH15 mRNA

NCBI chr20:13,996,383...15,495,206
Ensembl chr20:13,999,116...15,493,958

G

protocadherin beta 19

decreases expression

ISO

Malathion results in decreased expression of PCDHB12 mRNA

NCBI chr18:29,204,838...29,207,646

G

protocadherin gamma subfamily B, 1

increases expression

ISO

Malathion results in increased expression of PCDHGB1 mRNA

NCBI chr18:29,501,739...29,508,024

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
increases expression

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

proliferating cell nuclear antigen

multiple interactions
increases expression

ISO

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphodiesterase 6C

decreases expression

ISO

Malathion results in decreased expression of PDE6C mRNA

NCBI chr 1:245,322,015...245,377,874
Ensembl chr 1:245,322,015...245,377,852

G

protein disulfide isomerase family A, member 2

decreases expression

ISO

Malathion results in decreased expression of PDIA2 mRNA

NCBI chr10:15,720,301...15,723,386
Ensembl chr10:15,720,301...15,723,396

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Malathion results in decreased expression of PEBP1 mRNA

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

paternally expressed 10

increases expression

ISO

Malathion results in increased expression of PEG10 mRNA

NCBI chr 4:33,809,026...33,822,224
Ensembl chr 4:33,817,190...33,819,166
Ensembl chr 4:33,817,190...33,819,166

G

profilin 1

decreases expression

ISO

Malathion results in decreased expression of PFN1 mRNA

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

prohibitin 1

decreases expression

ISO

Malathion results in decreased expression of PHB1 mRNA

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

paired-like homeodomain 1

decreases expression

ISO

Malathion results in decreased expression of PITX1 mRNA

NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,799,319...8,805,476

G

plasminogen activator, tissue type

decreases expression

ISO

Malathion results in decreased expression of PLAT mRNA

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

plasminogen activator, urokinase

increases expression

ISO

Malathion results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

increases expression

ISO

Malathion results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase C, beta 4

increases expression

ISO

Malathion results in increased expression of PLCB4 mRNA

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113

G

pleckstrin homology and coiled-coil domain containing D1

decreases expression

ISO

Malathion results in decreased expression of PLEKHD1 mRNA

NCBI chr 6:100,340,655...100,371,942
Ensembl chr 6:106,071,901...106,117,826

G

perilipin 1

increases expression

ISO

Malathion results in increased expression of PLIN1 mRNA

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206

G

perilipin 2

increases expression

ISO

Malathion results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

proteolipid protein 1

decreases expression

ISO

Malathion results in decreased expression of PLP1 mRNA

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:104,975,780...104,993,314

G

plastin 3

increases expression

ISO

Malathion results in increased expression of PLS3 mRNA

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

plasmalemma vesicle associated protein

decreases expression

ISO

Malathion results in decreased expression of PLVAP mRNA

NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,218,967...18,231,454

G

PML nuclear body scaffold

decreases expression

ISO

Malathion results in decreased expression of PML mRNA

NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083

G

peroxisome proliferator activated receptor alpha

decreases expression

ISO

Malathion results in decreased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

protein kinase D1

increases expression

ISO

Malathion results in increased expression of PRKD1 mRNA

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

prospero homeobox 2

decreases expression

ISO

Malathion results in decreased expression of PROX2 mRNA

NCBI chr 6:104,731,385...104,758,619
Ensembl chr 6:110,462,456...110,489,684

G

protein Z, vitamin K-dependent plasma glycoprotein

decreases expression

ISO

Malathion results in decreased expression of PROZ mRNA

NCBI chr16:76,450,013...76,463,558
Ensembl chr16:83,152,152...83,165,619

G

pre T-cell antigen receptor alpha

decreases expression

ISO

Malathion results in decreased expression of PTCRA mRNA

NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:21,716,522...21,726,751

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

glycogen phosphorylase L

multiple interactions
increases expression

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA]

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB11 family interacting protein 3

increases expression

ISO

Malathion results in increased expression of RAB11FIP3 mRNA

NCBI chr10:15,507,151...15,591,173
Ensembl chr10:15,507,151...15,591,173

G

RAB3C, member RAS oncogene family

decreases expression

ISO

Malathion results in decreased expression of RAB3C mRNA

NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:43,361,093...43,577,022

G

Rap guanine nucleotide exchange factor 5

increases expression

ISO

Malathion results in increased expression of RAPGEF5 mRNA

NCBI chr 6:144,588,162...144,822,908
Ensembl chr 6:144,580,976...144,822,908

G

retinol binding protein 3

decreases expression

ISO

Malathion results in decreased expression of RBP3 mRNA

NCBI chr16:9,273,787...9,282,255
Ensembl chr16:9,273,787...9,282,646

G

retinol binding protein 7

decreases expression

ISO

Malathion results in decreased expression of RBP7 mRNA

NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:165,172,785...165,177,399

G

regulator of DNA class I crossover intermediates 1

decreases expression

ISO

Malathion results in decreased expression of REDIC1 mRNA

NCBI chr 7:122,318,495...122,386,002
Ensembl chr 7:124,198,055...124,265,543

G

RELA proto-oncogene, NF-kB subunit

increases expression
multiple interactions

EXP
ISO

Malathion results in increased expression of RELA mRNA
Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]

PMID:28987951 PMID:30673264

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reelin

increases expression

ISO

Malathion results in increased expression of RELN mRNA

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

replication factor C subunit 3

decreases expression

ISO

Malathion results in decreased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:5,836,553...5,847,340

G

RFT1 homolog

decreases expression

ISO

Malathion results in decreased expression of RFT1 mRNA

NCBI chr16:5,833,521...5,867,578
Ensembl chr16:5,833,546...5,880,165

G

ras homolog family member A

decreases activity

ISO

Malathion results in decreased activity of RHOA protein

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

Rhox homeobox family member 13

increases expression

ISO

Malathion results in increased expression of RHOXF1 mRNA

NCBI chr X:121,776,875...121,783,406
Ensembl chr X:121,776,875...121,783,406

G

RIMS binding protein 2

decreases expression

ISO

Malathion results in decreased expression of RIMBP2 mRNA

NCBI chr12:27,747,615...27,946,256
Ensembl chr12:33,384,007...33,593,999

G

ribonuclease A family member 6

increases expression

EXP

Malathion results in increased expression of RNASE6 mRNA

NCBI chr15:24,354,305...24,357,289
Ensembl chr15:26,827,009...26,830,825

G

ring finger protein 170

increases expression

ISO

Malathion results in increased expression of RNF170 mRNA

NCBI chr16:72,631,638...72,656,893
Ensembl chr16:72,631,638...72,656,469

G

ring finger protein 183

increases expression

ISO

Malathion results in increased expression of RNF183 mRNA

NCBI chr 5:80,892,683...80,914,037
Ensembl chr 5:80,892,190...80,902,196

G

roundabout guidance receptor 4

decreases expression

ISO

Malathion results in decreased expression of ROBO4 mRNA

NCBI chr 8:45,308,739...45,322,522
Ensembl chr 8:45,308,739...45,322,531

G

rabphilin 3A

decreases expression

ISO

Malathion results in decreased expression of RPH3A mRNA

NCBI chr12:35,542,389...35,618,901
Ensembl chr12:41,200,089...41,279,531

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

ISO

Malathion results in increased expression of RRAD mRNA

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

retinoschisin 1

increases expression

ISO

Malathion results in increased expression of RS1 mRNA

NCBI chr X:37,771,135...37,800,894
Ensembl chr X:37,771,135...37,800,894

G

radical S-adenosyl methionine domain containing 2

increases expression

ISO

Malathion results in increased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320

G

R-spondin 2

decreases expression

ISO

Malathion results in decreased expression of RSPO2 mRNA

NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:75,987,817...76,123,654

G

RT1 class Ia, locus A2

decreases expression

ISO

Malathion results in decreased expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class I, locus CE16

decreases expression

ISO

Malathion results in decreased expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548

G

RUNX family transcription factor 1

increases expression

ISO

Malathion results in increased expression of RUNX1 mRNA mutant form

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

S100 calcium binding protein A1

decreases expression

ISO

Malathion results in decreased expression of S100A1 mRNA

NCBI chr 2:178,291,503...178,296,346
Ensembl chr 2:178,291,503...178,296,346

G

secretogranin V

increases expression

ISO

Malathion results in increased expression of SCG5 mRNA

NCBI chr 3:120,998,420...121,042,881
Ensembl chr 3:120,998,420...121,042,795

G

sodium voltage-gated channel alpha subunit 9

decreases expression

ISO

Malathion results in decreased expression of SCN9A mRNA

NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:71,553,189...71,701,377

G

serpin family B member 2

increases expression

ISO

Malathion results in increased expression of SERPINB2 mRNA

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031

G

surfactant protein B

decreases expression
multiple interactions

ISO
EXP

Malathion results in decreased expression of SFTPB mRNA
Rosmarinic Acid inhibits the reaction [Malathion results in decreased expression of SFTPB protein]; thymoquinone inhibits the reaction [Malathion results in decreased expression of SFTPB mRNA]
Malathion results in decreased expression of SFTPB mRNA; Malathion results in decreased expression of SFTPB protein

PMID:33510276 PMID:34262720 PMID:37047231

NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646

G

sphingosine-1-phosphate phosphatase 2

increases expression

ISO

Malathion results in increased expression of SGPP2 mRNA

NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:87,211,717...87,333,132

G

SHC adaptor protein 1

increases expression

ISO

Malathion results in increased expression of SHC1 mRNA

NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914

G

shisa family member 3

increases expression

ISO

Malathion results in increased expression of SHISA3 mRNA

NCBI chr14:40,917,563...40,922,135
Ensembl chr14:40,917,564...40,922,135

G

shisa family member 9

increases expression

ISO

Malathion results in increased expression of SHISA9 mRNA

NCBI chr10:3,335,616...3,629,334
Ensembl chr10:3,844,741...4,135,082

G

shootin 1

decreases expression

ISO

Malathion results in decreased expression of SHTN1 mRNA

NCBI chr 1:268,108,095...268,211,947
Ensembl chr 1:268,108,097...268,211,947

G

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

ISO

Malathion results in decreased expression of SLC14A1 mRNA

NCBI chr18:71,565,453...71,608,807
Ensembl chr18:73,840,569...73,870,489

G

solute carrier family 22 member 2

multiple interactions

ISO

Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 6

multiple interactions

ISO

Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 4 member 5

decreases expression

ISO

Malathion results in decreased expression of SLC4A5 mRNA

NCBI chr 4:117,267,803...117,368,024
Ensembl chr 4:117,267,822...117,368,024

G

solute carrier organic anion transporter family, member 4a1

increases expression

ISO

Malathion results in increased expression of SLCO4A1 mRNA

NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:187,936,820...187,955,871

G

small integral membrane protein 32

decreases expression

ISO

Malathion results in decreased expression of SMIM32 mRNA

NCBI chr17:7,853,492...7,857,235
Ensembl chr17:7,858,465...7,863,319

G

synuclein alpha

increases expression
multiple interactions

EXP

Malathion results in increased expression of SNCA mRNA; Malathion results in increased expression of SNCA protein
crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

syntrophin, gamma 1

decreases expression

ISO

Malathion results in decreased expression of SNTG1 mRNA

NCBI chr 5:9,980,550...10,794,666
Ensembl chr 5:15,046,102...15,583,468

G

suppressor of cytokine signaling 3

decreases expression

ISO

Malathion results in decreased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

increases activity
multiple interactions
decreases expression

EXP
ISO

Malathion results in increased activity of SOD1 protein
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein]

PMID:20194575 PMID:30409133

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP
ISO

alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein
Malathion results in decreased expression of SOD2 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]

PMID:20194575 PMID:30409133

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spermatogenesis associated 17

decreases expression

ISO

Malathion results in decreased expression of SPATA17 mRNA

NCBI chr13:101,137,415...101,316,221
Ensembl chr13:101,137,415...101,316,376

G

speedy/RINGO cell cycle regulator family member A

increases expression

ISO

Malathion results in increased expression of SPDYA mRNA

NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:29,626,542...29,674,951

G

serine peptidase inhibitor Kazal type 13

decreases expression

ISO

Malathion results in decreased expression of SPINK13 mRNA

NCBI chr18:56,064,839...56,206,257
Ensembl chr18:58,335,146...58,476,569

G

serine peptidase inhibitor, Kazal type 4

decreases expression

ISO

Malathion results in decreased expression of SPINK4 mRNA

NCBI chr 5:60,811,899...60,860,823
Ensembl chr 5:60,849,060...60,860,823

G

serine and arginine rich splicing factor 5

decreases expression

EXP

Malathion results in decreased expression of SRSF5 mRNA

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

SCO-spondin

decreases expression

ISO

Malathion results in decreased expression of SSPOP mRNA

NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:78,727,275...78,781,315

G

somatostatin

decreases expression

ISO

Malathion results in decreased expression of SST mRNA

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

somatostatin receptor 2

increases expression

ISO

Malathion results in increased expression of SSTR2 mRNA

NCBI chr10:99,163,353...99,170,519
Ensembl chr10:99,162,740...99,183,863

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 2

increases expression

ISO

Malathion results in increased expression of ST6GAL2 mRNA

NCBI chr 9:9,181,744...9,274,161
Ensembl chr 9:9,509,548...9,594,007

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases expression

EXP

Malathion results in increased expression of ST8SIA1 mRNA

NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:177,520,926...177,651,553

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

increases expression

ISO

Malathion results in increased expression of ST8SIA4 mRNA

NCBI chr 9:103,437,479...103,532,008
Ensembl chr 9:103,437,479...103,532,008

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

ISO

Malathion results in decreased expression of STAR mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

decreases phosphorylation

EXP

Malathion results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 5B

decreases activity

ISO

Malathion results in decreased activity of STAT5B protein

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

serine/threonine kinase 36

decreases expression

ISO

Malathion results in decreased expression of STK36 mRNA

NCBI chr 9:83,625,905...83,652,785
Ensembl chr 9:83,626,030...83,653,525

G

signaling receptor and transporter of retinol STRA6

decreases expression

ISO

Malathion results in decreased expression of STRA6 mRNA

NCBI chr 8:67,444,757...67,464,719
Ensembl chr 8:67,444,742...67,464,720

G

transcription factor 7 like 1

increases expression

ISO

Malathion results in increased expression of TCF7L1 mRNA

NCBI chr 4:106,238,892...106,404,012
Ensembl chr 4:106,238,896...106,403,421

G

trichohyalin-like 1

decreases expression

ISO

Malathion results in decreased expression of TCHHL1 mRNA

NCBI chr 2:179,134,941...179,138,467
Ensembl chr 2:181,818,448...181,821,678

G

tudor domain containing 1

increases expression

ISO

Malathion results in increased expression of TDRD1 mRNA

NCBI chr 1:265,876,858...265,924,357
Ensembl chr 1:265,880,946...265,924,356

G

tudor domain containing 6

increases expression

ISO

Malathion results in increased expression of TDRD6 mRNA

NCBI chr 9:24,841,259...24,856,621
Ensembl chr 9:24,841,255...24,856,621

G

testis development related protein

decreases expression

ISO

Malathion results in decreased expression of TDRP mRNA

NCBI chr16:75,624,047...75,652,635
Ensembl chr16:82,314,220...82,354,861

G

TEK receptor tyrosine kinase

increases expression

ISO

Malathion results in increased expression of TEK mRNA

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

tet methylcytosine dioxygenase 1

affects expression

EXP

Malathion affects the expression of TET1 mRNA

NCBI chr20:25,766,806...25,839,598
Ensembl chr20:25,760,057...25,832,730

G

tet methylcytosine dioxygenase 2

decreases expression

EXP

Malathion results in decreased expression of TET2 mRNA

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186

G

tet methylcytosine dioxygenase 3

affects expression

EXP

Malathion affects the expression of TET3 mRNA

NCBI chr 4:117,425,106...117,525,495
Ensembl chr 4:117,429,857...117,520,486

G

tissue factor pathway inhibitor 2

increases expression

ISO

Malathion results in increased expression of TFPI2 mRNA

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426

G

transferrin receptor

increases expression

ISO

Malathion results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

thyroglobulin

decreases expression

EXP

Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein

NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539

G

tyrosine hydroxylase

decreases expression

ISO

Malathion results in decreased expression of TH protein

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

TIFA inhibitor

decreases expression

ISO

Malathion results in decreased expression of TIFAB mRNA

NCBI chr17:8,438,622...8,441,750
Ensembl chr17:8,433,862...8,444,360

G

TIMP metallopeptidase inhibitor 3

decreases expression

EXP

Malathion results in decreased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

tight junction protein 1

multiple interactions
decreases expression

EXP

[Malathion co-treated with Lead] results in decreased expression of TJP1 protein
Malathion results in decreased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tight junction protein 2

multiple interactions
decreases expression

EXP

[Malathion co-treated with Lead] results in decreased expression of TJP2 protein
Malathion results in decreased expression of TJP2 protein

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

G

toll-like receptor 4

multiple interactions
increases expression

ISO

Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

toll-like receptor 8

increases expression

ISO

Malathion results in increased expression of TLR8 mRNA

NCBI chr X:30,708,714...30,733,104
Ensembl chr X:30,708,033...30,737,079

G

transmembrane protein 114

decreases expression

ISO

Malathion results in decreased expression of TMEM114 mRNA

NCBI chr10:7,168,998...7,185,251
Ensembl chr10:7,676,380...7,691,883

G

transmembrane protein 158

increases expression

ISO

Malathion results in increased expression of TMEM158 mRNA

NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:131,787,277...131,796,882

G

transmembrane protein 241

decreases expression

ISO

Malathion results in decreased expression of TMEM241 mRNA

NCBI chr18:3,440,866...3,593,099
Ensembl chr18:3,442,212...3,593,218

G

transmembrane protein 65

increases expression

ISO

Malathion results in increased expression of TMEM65 mRNA

NCBI chr 7:92,163,632...92,268,430
Ensembl chr 7:92,163,635...92,268,214

G

tumor necrosis factor

increases expression
multiple interactions

EXP
ISO

Malathion results in increased expression of TNF mRNA
Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA]

PMID:28987951 PMID:37047231

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 6

increases expression

ISO

Malathion results in increased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

TNF alpha induced protein 8 like 3

decreases expression

ISO

Malathion results in decreased expression of TNFAIP8L3 mRNA

NCBI chr 8:54,413,503...54,455,512
Ensembl chr 8:63,310,107...63,318,501

G

TNF superfamily member 15

affects expression

ISO

Malathion affects the expression of TNFSF15 mRNA

NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882

G

TNFAIP3 interacting protein 3

increases expression

ISO

Malathion results in increased expression of TNIP3 mRNA

NCBI chr 4:94,867,258...94,908,780
Ensembl chr 4:96,140,768...96,238,534

G

tumor protein p53

multiple interactions
increases expression

ISO
EXP

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]
Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
Malathion results in increased expression of TRP53 protein
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein]

PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible protein 3

increases expression
multiple interactions

ISO

Malathion results in increased expression of TP53I3 mRNA
[Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA

NCBI chr 6:27,818,327...27,825,753

G

TPD52 like 3

decreases expression

ISO

Malathion results in decreased expression of TPD52L3 mRNA

NCBI chr 1:237,195,695...237,197,988
Ensembl chr 1:237,187,252...237,201,603

G

translocated promoter region, nuclear basket protein

increases expression

ISO

Malathion results in increased expression of TPR mRNA

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

translocation associated membrane protein 1-like 1

increases expression

ISO

Malathion results in increased expression of TRAM1L1 mRNA

NCBI chr 2:212,511,130...212,513,311
Ensembl chr 2:215,195,364...215,198,082

G

tripartite motif-containing 35

decreases expression

ISO

Malathion results in decreased expression of TRIM35 mRNA

NCBI chr15:40,493,697...40,510,246
Ensembl chr15:44,656,322...44,685,765

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

EXP

Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein

NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:105,142,931...105,193,826

G

transient receptor potential cation channel, subfamily C, member 4

increases expression
decreases expression

EXP
ISO

Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein
Malathion results in decreased expression of TRPC4 mRNA

PMID:22674931 PMID:37047231

NCBI chr 2:140,457,841...140,629,556
Ensembl chr 2:140,458,296...140,626,969

G

TRPC5 opposite strand

increases expression

ISO

Malathion results in increased expression of TRPC5OS mRNA

NCBI chr X:108,025,172...108,044,201
Ensembl chr X:112,821,048...112,844,004

G

thyroid stimulating hormone receptor

decreases expression

EXP

Malathion results in decreased expression of TSHR protein

NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010

G

tetratricopeptide repeat domain 9

decreases expression

ISO

Malathion results in decreased expression of TTC9 mRNA

NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:107,064,527...107,099,361

G

tumor suppressor 2, mitochondrial calcium regulator

decreases expression

ISO

Malathion results in decreased expression of TUSC2 mRNA

NCBI chr 8:117,115,479...117,118,697
Ensembl chr 8:117,115,479...117,118,697

G

twist family bHLH transcription factor 1

increases expression

ISO

Malathion results in increased expression of TWIST1 mRNA

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

thioredoxin reductase 3

decreases expression

ISO

Malathion results in decreased expression of TXNRD3 mRNA

NCBI chr 4:123,629,768...123,669,713
Ensembl chr 4:123,648,750...123,668,552

G

thymidylate synthetase

decreases expression

ISO

Malathion results in decreased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

ubiquitin D

increases expression

ISO

Malathion results in increased expression of UBD mRNA

NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,390,600...1,413,965

G

uromodulin-like 1

increases expression

ISO

Malathion results in increased expression of UMODL1 mRNA

NCBI chr20:9,027,751...9,087,133
Ensembl chr20:9,029,128...9,086,613

G

ubiquitin specific peptidase 2

increases expression

ISO

Malathion results in increased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

ubiquitin specific peptidase 27, X-linked

increases expression

ISO

Malathion results in increased expression of USP27X mRNA

NCBI chr X:17,795,506...17,798,741
Ensembl chr X:17,794,884...17,798,879

G

von Hippel-Lindau tumor suppressor

decreases expression

ISO

Malathion results in decreased expression of VHL mRNA

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991

G

V-set pre-B cell surrogate light chain 3

increases expression

ISO

Malathion results in increased expression of VPREB3 mRNA

NCBI chr20:12,716,862...12,720,108

G

WBP2 N-terminal like

decreases expression

ISO

Malathion results in decreased expression of WBP2NL mRNA

NCBI chr 7:115,694,910...115,710,912
Ensembl chr 7:115,694,922...115,710,689

G

WAP four-disulfide core domain 6A

decreases expression

ISO

Malathion results in decreased expression of WFDC6 mRNA

NCBI chr 3:173,724,681...173,728,489
Ensembl chr 3:173,724,681...173,731,790

G

WAS/WASL interacting protein family, member 3

decreases expression

ISO

Malathion results in decreased expression of WIPF3 mRNA

NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:84,880,740...84,961,524

G

WT1 transcription factor

increases expression

ISO

Malathion results in increased expression of WT1 mRNA

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

G

XK related 4

decreases expression

ISO

Malathion results in decreased expression of XKR4 mRNA

NCBI chr 5:15,896,818...16,297,733
Ensembl chr 5:20,693,966...21,080,579

G

zinc finger protein 42

decreases expression

ISO

Malathion results in decreased expression of ZFP42 mRNA

NCBI chr16:55,568,903...55,577,883
Ensembl chr16:55,568,093...55,578,170
Ensembl chr 4:55,568,093...55,578,170

G

zinc finger protein, multitype 2

increases expression

ISO

Malathion results in increased expression of ZFPM2 mRNA

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:73,563,732...74,001,041

G

zinc finger and SCAN domain containing 5B

decreases expression

ISO

Malathion results in decreased expression of ZSCAN5B mRNA

NCBI chr 1:67,666,684...67,674,238
Ensembl chr 1:76,699,779...76,707,325

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
role	20820
application	20621
pharmaceutical	20416
drug	20416
anti-ulcer drug	1254
succinic acid	716
thiomalic acid	456
(R)-thiomalic acid	0
(S)-thiomalic acid	0
aurothiomalic acid +	0
diethyl 2-sulfanylbutanedioate +	454
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
heteroorganic entity	20219
organochalcogen compound	19904
organooxygen compound	19806
carbonyl compound	19440
dicarboxylic acids and O-substituted derivatives	12725
dicarboxylic acid	12722
alpha,omega-dicarboxylic acid	3182
succinic acid	716
thiomalic acid	456
(R)-thiomalic acid	0
(S)-thiomalic acid	0
aurothiomalic acid +	0
diethyl 2-sulfanylbutanedioate +	454

paths to the root