CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: anthocyanin
Accession: CHEBI:38697
browse the term
Definition: Any flavonoid that is a glycoside derivative of anthocyanidin. Anthocyanins are water-souluble plant pigments that generally occur as acidic salts exhibiting bright colours.
Synonyms: related_synonym: anthocyanins
alt_id: MESH:D000872
xref_mesh: MESH:D000872
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Acta2
actin alpha 2, smooth muscle
multiple interactions decreases expression
ISO EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] Anthocyanins results in decreased expression of ACTA2 mRNA; Anthocyanins results in decreased expression of ACTA2 protein Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]
CTD
PMID:30056145 PMID:30403199
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of AGER protein]
CTD
PMID:24795233
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of ATM protein
CTD
PMID:27444805
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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B2m
beta-2 microglobulin
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of B2M protein]
CTD
PMID:30825423
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bad
BCL2-associated agonist of cell death
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BAD protein modified form]; Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAD protein]
CTD
PMID:28856781
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAK1 protein]
CTD
PMID:28856781
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX protein]
CTD
PMID:30403199
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
CTD
PMID:28856781 PMID:30403199
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]
CTD
PMID:28856781
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Car1
carbonic anhydrase 1
decreases activity
ISO
Anthocyanins results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
Anthocyanins results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Casp1
caspase 1
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased activity of CASP1 protein]
CTD
PMID:24795233
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
CTD
PMID:28856781
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein]
CTD
PMID:28856781
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD
PMID:28856781
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD
PMID:30825423
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
CTD
PMID:30056145
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccn2
cellular communication network factor 2
decreases expression
ISO
Anthocyanins results in decreased expression of CCN2 mRNA
CTD
PMID:30056145
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccnb1
cyclin B1
increases expression multiple interactions
ISO
Anthocyanins results in increased expression of CCNB1 protein Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]
CTD
PMID:27444805
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdc25c
cell division cycle 25C
multiple interactions increases phosphorylation
ISO
Anthocyanins results in decreased expression of and results in increased phosphorylation of CDC25C protein Anthocyanins results in increased phosphorylation of CDC25C protein
CTD
PMID:27444805
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdh1
cadherin 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]
CTD
PMID:30403199
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]; Anthocyanins results in increased expression of and results in increased phosphorylation of CDK1 protein
CTD
PMID:27444805
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Anthocyanins results in increased expression of CDKN1A protein
CTD
PMID:27444805
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Anthocyanins results in increased expression of CDKN1B protein
CTD
PMID:27444805
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Chek1
checkpoint kinase 1
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of CHEK1 protein
CTD
PMID:27444805
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of CHEK2 protein
CTD
PMID:27444805
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Cldn4
claudin 4
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]
CTD
PMID:25451569
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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Col1a1
collagen type I alpha 1 chain
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
CTD
PMID:30403199
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col3a1
collagen type III alpha 1 chain
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]
CTD
PMID:30056145
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Ctsd
cathepsin D
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]
CTD
PMID:25451569
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2]
CTD
PMID:30056145
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases expression
EXP
Anthocyanins results in increased expression of CYP2C mRNA
CTD
PMID:18803703
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Anthocyanins results in increased expression of CYP2E1 mRNA
CTD
PMID:18803703
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
EXP
Anthocyanins results in increased expression of CYP3A2 mRNA
CTD
PMID:18803703
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Anthocyanins results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:18803703
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Fadd
Fas associated via death domain
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FADD protein]
CTD
PMID:28856781
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FAS protein]
CTD
PMID:28856781
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FASLG protein]
CTD
PMID:28856781
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Gsr
glutathione-disulfide reductase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
CTD
PMID:30825423
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gusb
glucuronidase, beta
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]
CTD
PMID:25451569
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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H2ax
H2A.X variant histone
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of H2AX protein
CTD
PMID:27444805
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein]
CTD
PMID:30825423
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased phosphorylation of IKBKB protein]
CTD
PMID:24795233
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Il10
interleukin 10
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
CTD
PMID:25451569
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
EXP ISO
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein] Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]
CTD
PMID:24795233 PMID:25451569 PMID:30056145
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Lcn2
lipocalin 2
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of LCN2 protein]
CTD
PMID:30825423
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]
CTD
PMID:30056145
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]
CTD
PMID:25451569 PMID:30825423
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased degradation of NFKBIA protein]
CTD
PMID:24795233
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein]
CTD
PMID:24795233
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein]
CTD
PMID:24795233
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]
CTD
PMID:28856781
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]
CTD
PMID:30056145
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pde5a
phosphodiesterase 5A
decreases activity
ISO
Anthocyanins results in decreased activity of PDE5A protein
CTD
PMID:15769121
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression
EXP
Anthocyanins results in increased expression of PIK3R1 mRNA
CTD
PMID:18803703
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pla2g2a
phospholipase A2 group IIA
increases expression
EXP
Anthocyanins results in increased expression of PLA2G2A mRNA
CTD
PMID:18803703
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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Plcd4
phospholipase C, delta 4
increases expression
EXP
Anthocyanins results in increased expression of PLCD4 mRNA
CTD
PMID:18803703
NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
Anthocyanins results in increased expression of POR mRNA
CTD
PMID:18803703
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein]
CTD
PMID:24795233
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pycard
PYD and CARD domain containing
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PYCARD protein]
CTD
PMID:24795233
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of RELA protein]
CTD
PMID:25451569
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Smad2
SMAD family member 2
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]
CTD
PMID:30403199
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Snca
synuclein alpha
decreases expression
ISO
Anthocyanins results in decreased expression of SNCA protein
CTD
PMID:29976995
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Tgfb1
transforming growth factor, beta 1
decreases expression multiple interactions
ISO EXP
Anthocyanins results in decreased expression of TGFB1 mRNA Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
CTD
PMID:30056145 PMID:30403199
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr1
transforming growth factor, beta receptor 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFBR1 protein]
CTD
PMID:30403199
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
G
Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]
CTD
PMID:30056145
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tjp1
tight junction protein 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]
CTD
PMID:25451569
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein] Anthocyanins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:18720166 PMID:25451569 PMID:30825423
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Txnip
thioredoxin interacting protein
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of TXNIP protein]
CTD
PMID:24795233
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Vim
vimentin
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM protein]
CTD
PMID:30403199
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xdh
xanthine dehydrogenase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of XDH protein]
CTD
PMID:30825423
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
Car1
carbonic anhydrase 1
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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