Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flavan
go back to main search page
Accession:CHEBI:38691 term browser browse the term
Definition:The simplest member of the class of flavans that is chromane substituted by a phenyl group at position 2.
Synonyms:exact_synonym: 2-phenyl-3,4-dihydro-2H-chromene
 related_synonym: 2-Phenylchroman;   2-phenylchromane;   3,4-dihydro-2-phenyl-2H-1-benzopyran;   Formula=C15H14O;   InChI=1S/C15H14O/c1-2-6-12(7-3-1)15-11-10-13-8-4-5-9-14(13)16-15/h1-9,15H,10-11H2;   InChIKey=QOLIPNRNLBQTAU-UHFFFAOYSA-N;   SMILES=C1Cc2ccccc2OC1c1ccccc1
 alt_id: CHEBI:24039;   CHEBI:36097
 xref: Beilstein:383899;   CAS:494-12-2;   MetaCyc:CPD-13729;   Reaxys:383899;   Wikipedia:Flavan



show annotations for term's descendants           Sort by:
(+)-dihydromyricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] CTD PMID:21871475 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] CTD PMID:21871475 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 7:113,419,882...113,438,343 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] CTD PMID:21871475 NCBI chr18:56,770,348...56,809,228 JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 3:169,805,299...169,836,040 JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression
decreases activity
ISO ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein
CTD PMID:22251058 NCBI chr10:102,257,413...102,263,086 JBrowse link
flavanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP flavanone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Ar androgen receptor affects binding EXP flavanone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO flavanone results in increased expression of BAX protein CTD PMID:22056764 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone results in decreased activity of CASP3 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:22056764 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions ISO [benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:22056764 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 multiple interactions ISO flavanone results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:22056764
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO flavanone results in increased expression of CDKN1A protein CTD PMID:22056764 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO flavanone results in increased expression of CDKN1B protein CTD PMID:22056764 NCBI chr 4:169,491,273...169,496,500 JBrowse link
G Cycs cytochrome c, somatic affects localization ISO flavanone affects the localization of CYCS protein CTD PMID:22056764 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO flavanone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
flavanone results in increased expression of CYP1A1 mRNA
flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
flavanone results in decreased activity of CYP1A1 protein
CTD PMID:17090139 PMID:20930378 PMID:21053930 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO flavanone results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO flavanone binds to and results in decreased activity of CYP1B1 protein
flavanone analog results in increased expression of CYP1B1 mRNA
CTD PMID:21053930 PMID:31621310 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
flavanone results in decreased activity of CYP3A4 protein
CTD PMID:21053930 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO flavanone results in increased expression of FAS mRNA CTD PMID:22056764 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Faslg Fas ligand increases expression ISO flavanone results in increased expression of FASLG mRNA CTD PMID:22056764 NCBI chr13:76,680,885...76,706,042 JBrowse link
G Maoa monoamine oxidase A decreases activity ISO flavanone results in decreased activity of MAOA protein CTD PMID:23009399 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO flavanone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:86,165,327...86,170,362 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO flavanone results in increased cleavage of PARP1 protein CTD PMID:22056764 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO flavanone results in increased expression of PPARG protein CTD PMID:22056764 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO flavanone results in increased expression of PTEN protein CTD PMID:22056764 NCBI chr 1:240,043,707...240,110,330 JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO flavanone results in decreased phosphorylation of RB1 protein CTD PMID:22056764 NCBI chr15:54,780,858...54,911,989 JBrowse link
G Shbg sex hormone binding globulin affects binding ISO flavanone binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO flavanone results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:22056764 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO flavanone analog results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:96,249,143...96,256,264 JBrowse link
kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 2:185,884,840...185,912,532 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr10:86,311,528...86,363,513 JBrowse link
liquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
CTD PMID:31589899 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO liquiritigenin results in increased expression of CXCL12 mRNA CTD PMID:28396216 NCBI chr 4:152,060,781...152,073,628 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO liquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO liquiritigenin results in increased activity of ESR1 protein CTD PMID:28396216 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO liquiritigenin results in increased activity of ESR2 protein CTD PMID:25106122 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
liquiritigenin results in increased expression of GCLC protein
CTD PMID:29908794 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
EXP liquiritigenin results in increased expression of GCLM protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
CTD PMID:29908794 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] CTD PMID:31589899 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] CTD PMID:29908794 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO
EXP
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]
CTD PMID:31589899 NCBI chr 9:64,073,610...64,084,332 JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]
CTD PMID:31589899 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions
ISO
EXP
NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
CTD PMID:29908794 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]
CTD PMID:31589899 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO
EXP
liquiritigenin results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
CTD PMID:26473469 PMID:29908794 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
CTD PMID:31589899 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr10:35,026,598...35,037,750 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 decreases activity ISO liquiritigenin results in decreased activity of TRPM3 protein CTD PMID:25361167 NCBI chr 1:219,673,200...220,557,610 JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] CTD PMID:23183181 NCBI chr  X:109,006,410...109,066,389 JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr 7:111,377,338...111,390,940 JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr11:82,519,996...82,568,156 JBrowse link
liquiritin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA CTD PMID:36008890 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in decreased expression of ABCC2 mRNA CTD PMID:36008890 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 mRNA CTD PMID:36008890 NCBI chr10:79,793,571...79,839,528 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA CTD PMID:36008890 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]
CTD PMID:31589899 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP liquiritin results in increased expression of GCLC protein
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
CTD PMID:29908794 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
liquiritin results in increased expression of GCLM protein
CTD PMID:29908794 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]
CTD PMID:31589899 PMID:36008890 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 mRNA; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 protein]
CTD PMID:29908794 PMID:36008890 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO
EXP
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]
CTD PMID:31589899 NCBI chr 9:64,073,610...64,084,332 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein] CTD PMID:36008890 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]
CTD PMID:31589899 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions
ISO
EXP
NFE2L2 gene mutant form results in decreased susceptibility to liquiritin
liquiritin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NFE2L2 protein]
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
CTD PMID:29908794 PMID:36008890 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]
CTD PMID:31589899 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 mRNA
CTD PMID:29908794 PMID:36008890 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein] CTD PMID:36008890 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
CTD PMID:31589899 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] CTD PMID:36008890 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:36008890 NCBI chr 6:100,613,045...100,626,670 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr10:35,026,598...35,037,750 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein] CTD PMID:36008890 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr 7:111,377,338...111,390,940 JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr11:82,519,996...82,568,156 JBrowse link
pinostrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of AARS1 mRNA CTD PMID:37777166 NCBI chr19:38,999,130...39,021,152 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
decreases response to substance
ISO [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to pinostrobin
CTD PMID:37259354 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Acvr1 activin A receptor type 1 increases expression ISO pinostrobin results in increased expression of ACVR1 mRNA CTD PMID:37777166 NCBI chr 3:63,387,378...63,506,980 JBrowse link
G Ahctf1 AT hook containing transcription factor 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of AHCTF1 protein CTD PMID:37164308 NCBI chr13:91,481,936...91,536,391 JBrowse link
G Aifm3 AIF family member 3 increases expression ISO pinostrobin results in increased expression of AIFM3 mRNA CTD PMID:37777166 NCBI chr11:83,504,859...83,523,630 JBrowse link
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 increases expression ISO pinostrobin results in increased expression of AREL1 mRNA CTD PMID:37777166 NCBI chr 6:104,560,556...104,617,712 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO pinostrobin results in increased expression of ASNS mRNA CTD PMID:37777166 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein CTD PMID:37208425 NCBI chr 8:62,724,939...62,829,040 JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO pinostrobin results in increased expression of ATP5F1A mRNA CTD PMID:37777166 NCBI chr18:73,567,537...73,575,473 JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO pinostrobin results in increased expression of AXL mRNA CTD PMID:37777166 NCBI chr 1:90,392,864...90,424,123 JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pinostrobin results in increased expression of BAD mRNA CTD PMID:37777166 NCBI chr 1:213,562,719...213,572,034 JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pinostrobin results in increased expression of BAK1 mRNA CTD PMID:37164308 NCBI chr20:5,102,334...5,111,615 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]
CTD PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO pinostrobin results in increased expression of BBC3 mRNA CTD PMID:37777166 NCBI chr 1:86,141,450...86,150,666 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
pinostrobin results in decreased expression of BCL2 protein
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]
CTD PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO pinostrobin results in increased expression of BCL2L11 mRNA CTD PMID:37777166 NCBI chr 3:135,820,042...135,857,330 JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression ISO pinostrobin results in decreased expression of BCL2L2 mRNA CTD PMID:37164308 NCBI chr15:28,346,449...28,361,627 JBrowse link
G Bmf Bcl2 modifying factor increases expression ISO pinostrobin results in increased expression of BMF mRNA CTD PMID:37777166 NCBI chr 3:125,953,466...125,974,087 JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 increases expression ISO pinostrobin results in increased expression of CALHM2 mRNA CTD PMID:37777166 NCBI chr 1:246,022,324...246,028,050 JBrowse link
G Capn3 calpain 3 increases expression ISO pinostrobin results in increased expression of CAPN3 mRNA CTD PMID:37777166 NCBI chr 3:127,860,002...127,913,677 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO
EXP
pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein
pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
CTD PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 increases expression ISO pinostrobin results in increased expression of CASP8 mRNA CTD PMID:37208425 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 increases expression ISO pinostrobin results in increased expression of CASP9 mRNA CTD PMID:37208425
G Cat catalase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cbs cystathionine beta synthase increases expression ISO pinostrobin results in increased expression of CBS mRNA CTD PMID:37777166 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Ccne1 cyclin E1 decreases expression ISO pinostrobin results in decreased expression of CCNE1 protein CTD PMID:37777166 NCBI chr 1:99,918,672...99,927,986 JBrowse link
G Cd14 CD14 molecule increases expression ISO pinostrobin results in increased expression of CD14 mRNA CTD PMID:37777166 NCBI chr18:28,609,558...28,611,409 JBrowse link
G Cd70 Cd70 molecule increases expression ISO pinostrobin results in increased expression of CD70 mRNA CTD PMID:37777166 NCBI chr 9:2,006,563...2,009,715 JBrowse link
G Cdc40 cell division cycle 40 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDC40 protein CTD PMID:37164308 NCBI chr20:44,273,080...44,325,605 JBrowse link
G Cdh1 cadherin 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDH1 protein CTD PMID:37164308 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein CTD PMID:37777166 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pinostrobin results in increased expression of CDKN1B protein CTD PMID:37777166 NCBI chr 4:169,491,273...169,496,500 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO pinostrobin results in increased expression of CEBPB mRNA CTD PMID:37777166 NCBI chr 3:176,817,005...176,818,436 JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO pinostrobin results in increased expression of CHAC1 mRNA CTD PMID:37777166 NCBI chr 3:126,796,131...126,799,352 JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO pinostrobin results in increased expression of CIDEB mRNA CTD PMID:37777166 NCBI chr15:29,252,208...29,256,482 JBrowse link
G Cldn7 claudin 7 increases expression ISO pinostrobin results in increased expression of CLDN7 mRNA CTD PMID:37777166 NCBI chr10:55,188,670...55,190,871 JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression ISO pinostrobin results in decreased expression of CRELD2 protein CTD PMID:37164308 NCBI chr 7:119,909,626...119,916,556 JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO pinostrobin results in increased expression of CTH mRNA CTD PMID:37777166 NCBI chr 2:249,634,731...249,661,066 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein
CTD PMID:37164308 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO pinostrobin results in increased expression of CXCR4 mRNA CTD PMID:37777166 NCBI chr13:42,630,383...42,634,288 JBrowse link
G Dcps decapping enzyme, scavenger increases expression ISO pinostrobin results in increased expression of DCPS mRNA CTD PMID:37777166 NCBI chr 8:41,729,507...41,782,222 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pinostrobin results in increased expression of DDIT3 mRNA CTD PMID:37777166 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO pinostrobin results in increased expression of DDIT4 mRNA CTD PMID:37777166 NCBI chr20:28,434,938...28,437,037 JBrowse link
G Dnase1 deoxyribonuclease 1 increases expression ISO pinostrobin results in increased expression of DNASE1 mRNA CTD PMID:37777166 NCBI chr10:11,498,930...11,505,151 JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO pinostrobin results in increased expression of DNASE2 mRNA CTD PMID:37777166 NCBI chr19:23,244,656...23,247,376 JBrowse link
G Doc2b double C2 domain beta increases phosphorylation ISO pinostrobin results in increased phosphorylation of DOC2B protein CTD PMID:37164308 NCBI chr10:60,628,029...60,653,267 JBrowse link
G Elmo1 engulfment and cell motility 1 increases expression ISO pinostrobin results in increased expression of ELMO1 mRNA CTD PMID:37777166 NCBI chr17:44,286,495...44,822,668 JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression ISO pinostrobin results in increased expression of ERC1 mRNA CTD PMID:37777166 NCBI chr 4:152,763,664...153,055,724 JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases expression ISO pinostrobin results in increased expression of ERCC2 mRNA CTD PMID:37777166 NCBI chr 1:88,161,342...88,175,102 JBrowse link
G Etv6 ETS variant transcription factor 6 increases expression ISO pinostrobin results in increased expression of ETV6 mRNA CTD PMID:37777166 NCBI chr 4:166,849,031...167,085,211 JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression ISO pinostrobin results in increased expression of FANK1 mRNA CTD PMID:37777166 NCBI chr 1:188,577,512...188,685,501 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pinostrobin results in increased expression of FAS mRNA CTD PMID:37208425 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fbh1 F-box DNA helicase 1 increases expression ISO pinostrobin results in increased expression of FBH1 mRNA CTD PMID:37777166 NCBI chr17:66,749,506...66,787,590 JBrowse link
G Fcmr Fc mu receptor increases expression ISO pinostrobin results in increased expression of FCMR mRNA CTD PMID:37777166 NCBI chr13:42,337,363...42,351,706 JBrowse link
G Fer1l4 fer-1-like family member 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of FER1L4 protein CTD PMID:37164308 NCBI chr 3:144,536,099...144,571,634 JBrowse link
G Flcn folliculin increases expression ISO pinostrobin results in increased expression of FLCN mRNA CTD PMID:37777166 NCBI chr10:45,088,164...45,107,581 JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases phosphorylation ISO pinostrobin results in decreased phosphorylation of FMO5 protein CTD PMID:37164308 NCBI chr 2:185,197,184...185,249,699 JBrowse link
G Foxa1 forkhead box A1 increases expression ISO pinostrobin results in increased expression of FOXA1 mRNA CTD PMID:37777166 NCBI chr 6:75,099,907...75,136,534 JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression
ISO pinostrobin results in increased expression of and affects the localization of FOXO3 protein
pinostrobin results in increased expression of FOXO3 mRNA
CTD PMID:37777166 NCBI chr20:47,251,968...47,348,254 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:37866152 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO pinostrobin results in increased expression of FYN mRNA CTD PMID:37777166 NCBI chr20:44,322,635...44,514,498 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO pinostrobin results in increased expression of GADD45A mRNA CTD PMID:37777166 NCBI chr 4:97,484,497...97,486,799 JBrowse link
G Glb1 galactosidase, beta 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of GLB1 protein CTD PMID:37164308 NCBI chr 8:122,963,718...123,036,326 JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO pinostrobin results in increased expression of GRINA mRNA CTD PMID:37777166 NCBI chr 7:107,962,194...107,965,372 JBrowse link
G Grn granulin precursor increases expression ISO pinostrobin results in increased expression of GRN mRNA CTD PMID:37777166 NCBI chr10:87,387,672...87,393,777 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:37342552 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] CTD PMID:37342552 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hip1 huntingtin interacting protein 1 increases expression ISO pinostrobin results in increased expression of HIP1 mRNA CTD PMID:37777166 NCBI chr12:26,769,868...26,904,367 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pinostrobin results in increased expression of HMOX1 mRNA CTD PMID:37777166 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hsh2d hematopoietic SH2 domain containing increases expression ISO pinostrobin results in increased expression of HSH2D mRNA CTD PMID:37777166 NCBI chr16:17,630,519...17,649,932 JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO pinostrobin results in increased expression of ID3 mRNA CTD PMID:37777166 NCBI chr 5:153,656,253...153,657,860 JBrowse link
G Il10 interleukin 10 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein] CTD PMID:38078205 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ing4 inhibitor of growth family, member 4 increases expression ISO pinostrobin results in increased expression of ING4 mRNA CTD PMID:37777166 NCBI chr 4:159,528,183...159,536,762 JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pinostrobin results in increased expression of INHBA mRNA CTD PMID:37777166 NCBI chr17:53,787,159...53,810,942 JBrowse link
G Ino80 INO80 complex ATPase subunit increases phosphorylation ISO pinostrobin results in increased phosphorylation of INO80 protein CTD PMID:37164308 NCBI chr 3:126,822,280...126,919,532 JBrowse link
G Irf7 interferon regulatory factor 7 increases expression ISO pinostrobin results in increased expression of IRF7 mRNA CTD PMID:37777166 NCBI chr 1:205,796,956...205,800,543 JBrowse link
G Itgam integrin subunit alpha M increases expression ISO pinostrobin results in increased expression of ITGAM mRNA CTD PMID:37777166 NCBI chr 1:192,089,496...192,139,947 JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO pinostrobin results in increased expression of ITPK1 mRNA CTD PMID:37777166 NCBI chr 6:127,475,589...127,609,320 JBrowse link
G Kdm2b lysine demethylase 2B increases expression ISO pinostrobin results in increased expression of KDM2B mRNA CTD PMID:37777166 NCBI chr12:39,224,422...39,362,126 JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein] CTD PMID:37342552 NCBI chr 3:36,078,432...36,081,851 JBrowse link
G Lgals2 galectin 2 increases expression ISO pinostrobin results in increased expression of LGALS2 mRNA CTD PMID:37777166 NCBI chr 7:112,283,630...112,290,228 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:37866152 NCBI chr 1:105,037,457...105,038,446 JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO pinostrobin results in increased expression of MADD mRNA CTD PMID:37777166 NCBI chr 3:77,114,330...77,157,865 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO pinostrobin results in decreased expression of MCL1 mRNA CTD PMID:37164308 NCBI chr 2:185,884,840...185,912,532 JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO pinostrobin results in increased expression of MEF2A mRNA CTD PMID:37777166 NCBI chr 1:120,847,874...120,982,488 JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO pinostrobin results in increased expression of MEF2D mRNA CTD PMID:37777166 NCBI chr 2:173,606,054...173,635,620 JBrowse link
G Mir410 microRNA 410 decreases expression
multiple interactions
ISO pinostrobin results in decreased expression of MIR410 mRNA
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
CTD PMID:37164308 NCBI chr 6:128,758,358...128,758,433 JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of MRPL1 protein CTD PMID:37164308 NCBI chr14:13,300,522...13,359,654 JBrowse link
G Mt3 metallothionein 3 increases expression ISO pinostrobin results in increased expression of MT3 mRNA CTD PMID:37777166 NCBI chr19:10,848,754...10,850,158 JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO pinostrobin results in increased expression of MUTYH mRNA CTD PMID:37777166 NCBI chr 5:130,274,034...130,286,149 JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression ISO pinostrobin results in increased expression of NAIP mRNA CTD PMID:37777166 NCBI chr 2:31,507,423...31,559,098 JBrowse link
G Ninj1 ninjurin 1 increases expression ISO pinostrobin results in increased expression of NINJ1 mRNA CTD PMID:37777166 NCBI chr17:15,659,208...15,668,115 JBrowse link
G Nisch nischarin increases expression ISO pinostrobin results in increased expression of NISCH mRNA CTD PMID:37777166 NCBI chr16:6,370,809...6,407,104 JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A increases expression ISO pinostrobin results in increased expression of NLRP1 mRNA CTD PMID:37777166 NCBI chr10:55,778,560...55,833,639 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein] CTD PMID:37342552 PMID:37866152 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pinostrobin results in increased expression of NOS3 mRNA CTD PMID:37777166 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO pinostrobin results in increased expression of NR4A1 mRNA CTD PMID:37777166 NCBI chr 7:132,368,399...132,389,300 JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO pinostrobin results in increased expression of NTSR1 mRNA CTD PMID:37777166 NCBI chr 3:187,983,778...188,033,934 JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression ISO pinostrobin results in increased expression of P2RX1 mRNA CTD PMID:37777166 NCBI chr10:57,618,586...57,633,648 JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO pinostrobin results in increased expression of P2RX7 mRNA CTD PMID:37777166 NCBI chr12:39,550,531...39,594,984 JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO pinostrobin results in increased expression of PDE1B mRNA CTD PMID:37777166 NCBI chr 7:134,627,378...134,654,581 JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 increases expression ISO pinostrobin results in increased expression of PELI3 mRNA CTD PMID:37777166 NCBI chr 1:202,230,034...202,242,900 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO pinostrobin results in increased expression of PHLDA3 mRNA CTD PMID:37777166 NCBI chr13:47,193,250...47,196,335 JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase increases expression ISO pinostrobin results in increased expression of PIM2 mRNA CTD PMID:37777166 NCBI chr  X:17,289,509...17,294,778 JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO pinostrobin results in increased expression of PLAUR mRNA CTD PMID:37777166 NCBI chr 1:89,181,363...89,196,308 JBrowse link
G Pld1 phospholipase D1 increases expression ISO pinostrobin results in increased expression of PLD1 protein CTD PMID:37164308 NCBI chr 2:112,777,820...112,975,857 JBrowse link
G Plec plectin decreases expression ISO pinostrobin results in decreased expression of PLEC protein CTD PMID:37164308 NCBI chr 7:109,768,447...109,829,798 JBrowse link
G Plxnd1 plexin D1 increases expression ISO pinostrobin results in increased expression of PLXND1 mRNA CTD PMID:37777166 NCBI chr 4:149,002,786...149,043,097 JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO pinostrobin results in increased expression of PMP22 mRNA CTD PMID:37777166 NCBI chr10:48,294,932...48,324,941 JBrowse link
G Pou3f3 POU class 3 homeobox 3 increases expression ISO pinostrobin results in increased expression of POU3F3 mRNA CTD PMID:37777166 NCBI chr 9:44,945,872...44,948,998 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO pinostrobin results in increased expression of PPARA mRNA CTD PMID:37777166 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein] CTD PMID:37342552 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression ISO pinostrobin results in increased expression of PTK2B mRNA CTD PMID:37777166 NCBI chr15:44,536,275...44,656,754 JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of QARS1 mRNA CTD PMID:37777166 NCBI chr 8:109,207,705...109,215,738 JBrowse link
G Ret ret proto-oncogene increases expression ISO pinostrobin results in increased expression of RET mRNA CTD PMID:37777166 NCBI chr 4:152,998,344...153,040,556 JBrowse link
G Rnf130 ring finger protein 130 increases expression ISO pinostrobin results in increased expression of RNF130 mRNA CTD PMID:37777166 NCBI chr10:34,342,835...34,456,048 JBrowse link
G Rnf216 ring finger protein 216 increases expression ISO pinostrobin results in increased expression of RNF216 mRNA CTD PMID:37777166 NCBI chr12:11,454,752...11,576,305 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 increases expression ISO pinostrobin results in increased expression of HLA-F mRNA CTD PMID:37777166 NCBI chr20:3,403,418...3,479,476 JBrowse link
G Rtkn rhotekin increases expression ISO pinostrobin results in increased expression of RTKN mRNA CTD PMID:37777166 NCBI chr 4:115,640,813...115,657,952 JBrowse link
G Scfd2 sec1 family domain containing 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCFD2 protein CTD PMID:37164308 NCBI chr14:33,683,348...34,008,232 JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCN2A protein CTD PMID:37164308 NCBI chr 3:70,710,862...70,845,569 JBrowse link
G Scx scleraxis bHLH transcription factor increases expression ISO pinostrobin results in increased expression of SCX mRNA CTD PMID:37777166 NCBI chr 7:108,176,608...108,178,626 JBrowse link
G Selenos selenoprotein S increases expression ISO pinostrobin results in increased expression of SELENOS mRNA CTD PMID:37777166 NCBI chr 1:119,659,779...119,669,546 JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO pinostrobin results in increased expression of SERPINF1 mRNA CTD PMID:37777166 NCBI chr10:60,250,198...60,262,593 JBrowse link
G Sfrp5 secreted frizzled-related protein 5 multiple interactions
increases phosphorylation
increases expression
ISO pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]
pinostrobin results in increased phosphorylation of SFRP5 protein
pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein
CTD PMID:37164308 NCBI chr 1:241,006,762...241,011,224 JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression ISO pinostrobin results in increased expression of SHARPIN mRNA CTD PMID:37777166 NCBI chr 7:109,951,336...109,955,552 JBrowse link
G Shisa5 shisa family member 5 increases expression ISO pinostrobin results in increased expression of SHISA5 mRNA CTD PMID:37777166 NCBI chr 8:118,569,975...118,584,880 JBrowse link
G Slc10a5 solute carrier family 10, member 5 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SLC10A5 protein CTD PMID:37164308 NCBI chr 2:91,457,540...91,458,844 JBrowse link
G Slc25a5-ps11 solute carrier family 25 member 5, pseudogene 11 increases expression ISO pinostrobin results in increased expression of SLC25A6 mRNA CTD PMID:37777166 NCBI chr18:68,571,222...68,572,461 JBrowse link
G Slc46a2 solute carrier family 46, member 2 increases expression ISO pinostrobin results in increased expression of SLC46A2 mRNA CTD PMID:37777166 NCBI chr 5:74,800,226...74,808,128 JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO pinostrobin results in increased expression of SLC7A11 mRNA CTD PMID:37777166 NCBI chr 2:136,532,912...136,668,560 JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO pinostrobin results in increased expression of SLCO5A1 protein CTD PMID:37164308 NCBI chr 5:6,228,938...6,358,124 JBrowse link
G Smad3 SMAD family member 3 increases expression ISO pinostrobin results in increased expression of SMAD3 mRNA CTD PMID:37777166 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Smim7 small integral membrane protein 7 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SMIM7 protein CTD PMID:37164308 NCBI chr16:17,274,417...17,278,336 JBrowse link
G Stap2 signal transducing adaptor family member 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of STAP2 protein CTD PMID:37164308 NCBI chr 9:828,369...838,648 JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO pinostrobin results in increased expression of STAR mRNA CTD PMID:37777166 NCBI chr16:72,969,824...72,974,447 JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression ISO pinostrobin results in increased expression of STXBP1 mRNA CTD PMID:37777166 NCBI chr 3:16,076,725...16,138,431 JBrowse link
G Sycp2l synaptonemal complex protein 2-like increases expression ISO pinostrobin results in increased expression of SYCP2L mRNA CTD PMID:37777166 NCBI chr17:23,589,217...23,645,273 JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression ISO pinostrobin results in increased expression of TAF10 mRNA CTD PMID:37777166 NCBI chr 1:160,095,108...160,096,401 JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 increases expression ISO pinostrobin results in increased expression of TCIRG1 mRNA CTD PMID:37777166 NCBI chr 1:210,556,270...210,568,021 JBrowse link
G Tmem109 transmembrane protein 109 increases expression ISO pinostrobin results in increased expression of TMEM109 mRNA CTD PMID:37777166 NCBI chr 1:207,519,628...207,530,245 JBrowse link
G Tmem39a transmembrane protein 39a increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMEM39A protein CTD PMID:37164308 NCBI chr11:62,160,631...62,189,964 JBrowse link
G Tmem79 transmembrane protein 79 increases expression ISO pinostrobin results in increased expression of TMEM79 mRNA CTD PMID:37777166 NCBI chr 2:173,798,267...173,803,151 JBrowse link
G Tmprss4 transmembrane serine protease 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMPRSS4 protein CTD PMID:37164308 NCBI chr 8:45,475,819...45,508,409 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein] CTD PMID:37866152 NCBI chr13:22,442,930...22,501,257 JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO pinostrobin results in increased expression of TNFSF14 mRNA CTD PMID:37777166 NCBI chr 9:2,155,270...2,160,100 JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO pinostrobin results in increased expression of TNFSF9 mRNA CTD PMID:37777166 NCBI chr 9:2,031,011...2,033,345 JBrowse link
G Tp53 tumor protein p53 increases expression ISO pinostrobin results in increased expression of TP53 mRNA CTD PMID:37208425 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO pinostrobin results in increased expression of TRAP1 mRNA CTD PMID:37777166 NCBI chr10:11,971,259...12,005,306 JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO pinostrobin results in increased expression of TRIB3 mRNA CTD PMID:37777166 NCBI chr 3:161,269,939...161,275,533 JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 increases expression ISO pinostrobin results in increased expression of TRPM2 mRNA CTD PMID:37777166 NCBI chr20:10,703,568...10,753,189 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO pinostrobin results in increased expression of TRPV1 mRNA CTD PMID:37777166 NCBI chr10:58,349,936...58,375,021 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO pinostrobin results in increased expression of VEGFA mRNA CTD PMID:37777166 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO pinostrobin results in increased expression of XBP1 mRNA CTD PMID:37777166 NCBI chr14:84,604,623...84,609,707 JBrowse link
G Zfp746 zinc finger protein 746 increases expression ISO pinostrobin results in increased expression of ZNF746 mRNA CTD PMID:37777166 NCBI chr 4:77,055,008...77,078,968 JBrowse link
sophoranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO sophoranone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO sophoranone results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:14,321,771...14,343,886 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          oxygen atom 19559
            oxygen molecular entity 19559
              flavonoids 11631
                flavonoid 7234
                  flavans 3648
                    flavan 213
                      (2R)-flavan + 0
                      (2S)-flavan + 0
                      7,4'-di-O-galloyltricetiflavan 0
                      7-O-galloyltricetiflavan 0
                      flavanone + 207
                      flavanonol + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  oxacycle 17924
                                    benzopyran 11981
                                      1-benzopyran 11735
                                        flavonoid 7234
                                          flavans 3648
                                            flavan 213
                                              (2R)-flavan + 0
                                              (2S)-flavan + 0
                                              7,4'-di-O-galloyltricetiflavan 0
                                              7-O-galloyltricetiflavan 0
                                              flavanone + 207
                                              flavanonol + 6
paths to the root