|
G
|
Ahr
|
aryl hydrocarbon receptor
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
Ccnd1
|
cyclin D1
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
G
|
E2f1
|
E2F transcription factor 1
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
|
|
G
|
Etv6
|
ETS variant transcription factor 6
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802
|
|
G
|
Ido2
|
indoleamine 2,3-dioxygenase 2
|
decreases activity
|
ISO
|
1-methyltryptophan results in decreased activity of IDO2 protein
|
CTD |
PMID:32289347 |
|
NCBI chr16:74,161,761...74,200,651
Ensembl chr16:74,161,774...74,200,650
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
|
|
G
|
Pou5f1
|
POU class 5 homeobox 1
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
|
|
G
|
Runx1
|
RUNX family transcription factor 1
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925
|
|
G
|
Tdo2
|
tryptophan 2,3-dioxygenase
|
multiple interactions
|
ISO
|
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of TDO2 protein]
|
CTD |
PMID:35687267 |
|
NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586
|
|
|
G
|
Htr3a
|
5-hydroxytryptamine receptor 3A
|
multiple interactions
|
ISO
|
2-methyl-5-HT binds to and results in increased activity of HTR3A protein
|
CTD |
PMID:15802305 |
|
NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
|
CTD |
PMID:15802305 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
|
CTD |
PMID:15802305 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
|
G
|
Afp
|
alpha-fetoprotein
|
decreases expression
|
ISO
|
5-Hydroxytryptophan results in decreased expression of AFP mRNA
|
CTD |
PMID:32926198 |
|
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649
|
|
G
|
Ddc
|
dopa decarboxylase
|
multiple interactions
|
EXP
|
[DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin
|
CTD |
PMID:32243540 |
|
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
|
|
G
|
Gata4
|
GATA binding protein 4
|
decreases expression
|
ISO
|
5-Hydroxytryptophan results in decreased expression of GATA4 mRNA
|
CTD |
PMID:32926198 |
|
NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609
|
|
G
|
Nanog
|
Nanog homeobox
|
decreases expression
|
ISO
|
5-Hydroxytryptophan results in decreased expression of NANOG mRNA
|
CTD |
PMID:32926198 |
|
NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061
|
|
G
|
Pou5f1
|
POU class 5 homeobox 1
|
decreases expression
|
ISO
|
5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA
|
CTD |
PMID:32926198 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
|
|
G
|
Tph1
|
tryptophan hydroxylase 1
|
multiple interactions
|
EXP
|
[TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan
|
CTD |
PMID:32243540 |
|
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:106,085,953...106,312,484
|
|
|
G
|
Cyp2b3
|
cytochrome P450, family 2, subfamily b, polypeptide 3
|
decreases activity multiple interactions
|
ISO
|
5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
|
CTD |
PMID:26599973 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G
|
Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
multiple interactions decreases activity
|
ISO
|
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
|
CTD |
PMID:26599973 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
|
|
G
|
Cyp2d1
|
cytochrome P450, family 2, subfamily d, polypeptide 1
|
increases metabolic processing
|
EXP
|
CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine
|
CTD |
PMID:18191824 |
|
NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479
|
|
G
|
Cyp2d2
|
cytochrome P450, family 2, subfamily d, polypeptide 2
|
increases metabolic processing
|
EXP
|
CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine
|
CTD |
PMID:18191824 |
|
NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281
|
|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
multiple interactions decreases activity
|
ISO
|
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan
|
CTD |
PMID:26599973 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions decreases activity
|
ISO
|
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone
|
CTD |
PMID:26599973 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
|
|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
multiple interactions
|
ISO
|
CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine
|
CTD |
PMID:12777961 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
|
|
G
|
Htr7
|
5-hydroxytryptamine receptor 7
|
multiple interactions
|
ISO
|
[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP
|
CTD |
PMID:14578406 |
|
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:243,049,081...243,173,230
|
|
G
|
Kmo
|
kynurenine 3-monooxygenase
|
increases expression
|
EXP
|
5-Methoxytryptamine results in increased expression of KMO mRNA
|
CTD |
PMID:32243540 |
|
NCBI chr13:90,089,340...90,121,108
Ensembl chr13:90,089,463...90,125,151
|
|
G
|
Ppp1r1b
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B
|
decreases phosphorylation increases phosphorylation
|
ISO
|
5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein 5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein
|
CTD |
PMID:11880652 |
|
NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063
|
|
G
|
Sod2
|
superoxide dismutase 2
|
decreases expression
|
EXP
|
5-Methoxytryptamine results in decreased expression of SOD2 mRNA
|
CTD |
PMID:32243540 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Taar1
|
trace-amine-associated receptor 1
|
increases activity multiple interactions
|
ISO
|
5-Methoxytryptamine results in increased activity of TAAR1 protein [5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
|
CTD |
PMID:19725810 |
|
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:23,335,165...23,353,981
|
|
G
|
Tph1
|
tryptophan hydroxylase 1
|
decreases expression
|
EXP
|
5-Methoxytryptamine results in decreased expression of TPH1 mRNA
|
CTD |
PMID:32243540 |
|
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:106,085,953...106,312,484
|
|
|
G
|
Sult1a1
|
sulfotransferase family 1A member 1
|
multiple interactions
|
ISO EXP
|
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin]
|
CTD |
PMID:11181495 |
|
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
|
|
|
G
|
Adipor1
|
adiponectin receptor 1
|
multiple interactions
|
ISO
|
gramine binds to and results in increased activity of ADIPOR1 protein
|
CTD |
PMID:23691032 |
|
NCBI chr13:48,411,438...48,431,251
Ensembl chr13:48,411,826...48,431,255
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
decreases phosphorylation
|
ISO
|
gramine results in decreased phosphorylation of PPARA protein
|
CTD |
PMID:23691032 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
increases phosphorylation
|
ISO
|
gramine results in increased phosphorylation of PRKAA1 protein
|
CTD |
PMID:23691032 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
|
|
G
|
Prkaa2
|
protein kinase AMP-activated catalytic subunit alpha 2
|
increases phosphorylation
|
ISO
|
gramine results in increased phosphorylation of PRKAA2 protein
|
CTD |
PMID:23691032 |
|
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
|
|
|
G
|
Il13
|
interleukin 13
|
multiple interactions
|
EXP
|
ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein]
|
CTD |
PMID:18852015 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
|
|
G
|
Mmp1
|
matrix metallopeptidase 1
|
multiple interactions
|
EXP
|
ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA]
|
CTD |
PMID:18837084 |
|
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
|
|
G
|
Timp1
|
TIMP metallopeptidase inhibitor 1
|
multiple interactions
|
EXP
|
ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein]
|
CTD |
PMID:18837084 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
|
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
increases expression
|
ISO
|
Tryptophan results in increased expression of AHR mRNA
|
CTD |
PMID:32781018 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions decreases abundance
|
ISO
|
PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Tryptophan]
|
CTD |
PMID:39172838 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions increases expression
|
ISO
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA Tryptophan results in increased expression of CYP1A1 mRNA
|
CTD |
PMID:32781018 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions increases expression
|
ISO
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA Tryptophan results in increased expression of CYP1B1 mRNA
|
CTD |
PMID:32781018 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
G
|
Ido1
|
indoleamine 2,3-dioxygenase 1
|
increases expression increases abundance
|
ISO
|
Tryptophan results in increased expression of IDO1 protein IDO1 gene mutant form results in increased abundance of Tryptophan
|
CTD |
PMID:32781018 PMID:32871117 |
|
NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]
|
CTD |
PMID:32781018 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Igfbp1
|
insulin-like growth factor binding protein 1
|
increases expression multiple interactions
|
ISO
|
Tryptophan results in increased expression of IGFBP1 mRNA 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]
|
CTD |
PMID:32781018 |
|
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
|
|
G
|
Mapt
|
microtubule-associated protein tau
|
multiple interactions
|
ISO
|
[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan [amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan]
|
CTD |
PMID:39172838 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
|
|
G
|
Prl
|
prolactin
|
multiple interactions increases expression
|
ISO
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA] Tryptophan results in increased expression of PRL mRNA
|
CTD |
PMID:32781018 |
|
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
|
|
G
|
Slc7a5
|
solute carrier family 7 member 5
|
increases expression
|
ISO
|
Tryptophan results in increased expression of SLC7A5 mRNA
|
CTD |
PMID:32781018 |
|
NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412
|
|
G
|
Tdo2
|
tryptophan 2,3-dioxygenase
|
increases abundance
|
ISO
|
TDO2 gene mutant form results in increased abundance of Tryptophan
|
CTD |
PMID:32871117 |
|
NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586
|
|
G
|
Tph1
|
tryptophan hydroxylase 1
|
multiple interactions
|
EXP
|
[TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan
|
CTD |
PMID:32243540 |
|
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:106,085,953...106,312,484
|
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]
|
CTD |
PMID:23554006 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Gast
|
gastrin
|
multiple interactions
|
EXP
|
luzindole inhibits the reaction [Melatonin results in increased expression of GAST]
|
CTD |
PMID:12074098 |
|
NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]
|
CTD |
PMID:23554006 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
G
|
H19
|
H19 imprinted maternally expressed transcript
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of H19 RNA in C-kit+ cardiac progenitor cells]]
|
RGD |
PMID:27062045 |
RGD:158013773 |
NCBI chr 1:207,160,175...207,162,851
|
|
G
|
Kras
|
KRAS proto-oncogene, GTPase
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Kras protein in C-kit+ cardiac progenitor cells]]
|
RGD |
PMID:27062045 |
RGD:158013773 |
NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320
|
|
G
|
Mir675
|
microRNA 675
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of Mir675 RNA in C-kit+ cardiac progenitor cells]]
|
RGD |
PMID:27062045 |
RGD:158013773 |
NCBI chr 1:197,732,275...197,732,358
|
|
G
|
Mtnr1a
|
melatonin receptor 1A
|
multiple interactions
|
EXP
|
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]
|
CTD |
PMID:28238930 |
|
NCBI chr16:47,144,461...47,163,919
Ensembl chr16:53,876,964...53,896,421
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|
G
|
Mtnr1b
|
melatonin receptor 1B
|
multiple interactions
|
ISO EXP
|
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B protein luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
|
CTD |
PMID:11270484 PMID:21473625 PMID:28238930 |
|
NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:20,919,593...20,934,109
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]
|
CTD |
PMID:26283214 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PPARG protein]
|
CTD |
PMID:29734669 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
|
CTD |
PMID:25159133 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
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|
G
|
Prnp
|
prion protein
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein]
|
CTD |
PMID:29734669 |
|
NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]
|
CTD |
PMID:26283214 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]
|
CTD |
PMID:25159133 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]
|
CTD |
PMID:23554006 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]
|
CTD |
PMID:23554006 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
|
CTD |
PMID:26283214 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Trp53 protein in C-kit+ cardiac progenitor cells]]
|
RGD |
PMID:27062045 |
RGD:158013773 |
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
G
|
Usp10
|
ubiquitin specific peptidase 10
|
multiple interactions
|
ISO
|
luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Usp10 protein in C-kit+ cardiac progenitor cells]]
|
RGD |
PMID:27062045 |
RGD:158013773 |
NCBI chr19:64,881,255...64,923,522
Ensembl chr19:64,881,315...64,923,519
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein]
|
CTD |
PMID:28223141 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Abcb6
|
ATP binding cassette subfamily B member 6
|
multiple interactions decreases metabolic processing
|
ISO
|
[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin] ABCB6 gene mutant form results in decreased metabolism of Melatonin
|
CTD |
PMID:25623066 |
|
NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526
|
|
G
|
Acadm
|
acyl-CoA dehydrogenase medium chain
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACADM mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864
|
|
G
|
Acads
|
acyl-CoA dehydrogenase short chain
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr12:41,493,650...41,502,897
Ensembl chr12:47,154,276...47,164,103
|
|
G
|
Acan
|
aggrecan
|
increases expression
|
ISO
|
Melatonin results in increased expression of ACAN mRNA
|
CTD |
PMID:20738756 |
|
NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
|
|
G
|
Acat1
|
acetyl-CoA acetyltransferase 1
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACAT1 mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042
|
|
G
|
Ace2
|
angiotensin converting enzyme 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ACE2 protein]
|
CTD |
PMID:35844137 |
|
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of ACHE]; Melatonin inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Melatonin inhibits the reaction [Dexamethasone results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]]
|
CTD |
PMID:19705549 PMID:21986892 PMID:22013727 PMID:30372842 PMID:35526705 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Acot6
|
acyl-CoA thioesterase 6
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of ACOT6 mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr 6:103,732,372...103,741,446
|
|
G
|
Acsl4
|
acyl-CoA synthetase long-chain family member 4
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr X:110,739,633...110,803,416
Ensembl chr X:110,739,648...110,803,261
|
|
G
|
Acsm2
|
acyl-CoA synthetase medium-chain family member 2
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM2 mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453
|
|
G
|
Acsm3
|
acyl-CoA synthetase medium-chain family member 3
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM3 mRNA]
|
CTD |
PMID:35367536 |
|
NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
|
CTD |
PMID:26882442 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
decreases expression
|
ISO
|
Melatonin results in decreased expression of ADIPOQ mRNA
|
CTD |
PMID:20738756 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
|
|
G
|
Adora2b
|
adenosine A2B receptor
|
multiple interactions decreases expression
|
ISO
|
[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA] Melatonin results in decreased expression of ADORA2B mRNA
|
CTD |
PMID:21461237 |
|
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:47,439,701...47,456,091
|
|
G
|
Ager
|
advanced glycosylation end product-specific receptor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [sodium arsenite results in increased expression of AGER protein]
|
CTD |
PMID:29763682 |
|
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
|
|
G
|
Agt
|
angiotensinogen
|
decreases expression multiple interactions
|
EXP ISO
|
Melatonin results in decreased expression of AGT protein Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]
|
CTD |
PMID:19018803 PMID:35844137 |
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
|
|
G
|
Aif1
|
allograft inflammatory factor 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IBA1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of AIF1 protein]
|
CTD |
PMID:34673010 PMID:36566971 |
|
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
|
|
G
|
Aim2
|
absent in melanoma 2
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of AIM2 mRNA Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of AIM2 protein]; Melatonin inhibits the reaction [Nickel results in increased expression of AIM2 mRNA]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel inhibits the reaction [Melatonin results in decreased expression of AIM2 mRNA]
|
CTD |
PMID:36504304 PMID:38944328 |
|
NCBI chr13:88,397,516...88,439,325
Ensembl chr13:88,404,048...88,439,318
|
|
G
|
Akr7a3
|
aldo-keto reductase family 7 member A3
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA]
|
CTD |
PMID:20033131 |
|
NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases phosphorylation multiple interactions
|
ISO EXP
|
Melatonin results in increased phosphorylation of AKT1 protein Melatonin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA] [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]
|
CTD |
PMID:18078454 PMID:21138475 PMID:22225513 PMID:23374533 PMID:23963992 PMID:31330490 PMID:35568058 PMID:36343453 PMID:37975621 More...
|
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Alas1
|
5'-aminolevulinate synthase 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]
|
CTD |
PMID:24523661 |
|
NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642
|
|
G
|
Alb
|
albumin
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of ALB protein]; Melatonin inhibits the reaction [Monocrotaline results in decreased expression of ALB protein]
|
CTD |
PMID:16652224 PMID:37350538 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
|
|
G
|
Aldh5a1
|
aldehyde dehydrogenase 5 family, member A1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,558,347...40,586,714
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|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
increases expression multiple interactions
|
ISO EXP
|
Melatonin results in increased expression of ALPL mRNA Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of ALPL protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]; Melatonin inhibits the reaction [Capecitabine results in increased expression of ALPL protein]
|
CTD |
PMID:20738756 PMID:31809235 PMID:38179616 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
|
|
G
|
Amh
|
anti-Mullerian hormone
|
increases expression multiple interactions
|
EXP
|
Melatonin results in increased expression of AMH mRNA bisphenol A inhibits the reaction [Melatonin results in increased expression of AMH mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of AMH protein]
|
CTD |
PMID:33967032 PMID:36154502 |
|
NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867
|
|
G
|
Amy2a3
|
amylase 2a3
|
multiple interactions increases secretion
|
EXP
|
Capsaicin inhibits the reaction [Melatonin results in increased secretion of AMY2A3 protein]; Devazepide inhibits the reaction [Melatonin results in increased secretion of AMY2A3 protein]; tarazepide inhibits the reaction [Melatonin results in increased secretion of AMY2A3 protein]
|
CTD |
PMID:15009505 |
|
NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:204,005,840...204,014,413
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|
G
|
Aox1
|
aldehyde oxidase 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA]
|
CTD |
PMID:31330490 |
|
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:67,073,821...67,152,980
|
|
G
|
Apaf1
|
apoptotic peptidase activating factor 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772
|
|
G
|
Apex1
|
apurinic/apyrimidinic endodeoxyribonuclease 1
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in increased expression of APEX1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form] Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]] Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of APP protein
|
CTD |
PMID:10617124 PMID:18231852 PMID:18537544 PMID:33130240 PMID:35526705 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Ar
|
androgen receptor
|
multiple interactions increases expression
|
EXP
|
[Melatonin co-treated with Ethanol] results in increased expression of AR protein; Ethanol inhibits the reaction [Melatonin results in increased expression of AR protein]
|
CTD |
PMID:23591044 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
|
|
G
|
Arg1
|
arginase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of ARG1 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of ARG1 protein]
|
CTD |
PMID:36566971 |
|
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713
|
|
G
|
Arnt
|
aryl hydrocarbon receptor nuclear translocator
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of ARNT mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
|
|
G
|
Astl
|
astacin like metalloendopeptidase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of and affects the localization of ASTL protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of and affects the localization of ASTL protein]
|
CTD |
PMID:28178360 PMID:31931096 |
|
NCBI chr 3:114,563,135...114,580,295
Ensembl chr 3:135,016,444...135,032,177
|
|
G
|
Atf2
|
activating transcription factor 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]
|
CTD |
PMID:23591579 |
|
NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745
|
|
G
|
Atf4
|
activating transcription factor 4
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein] Melatonin inhibits the reaction [Atrazine results in increased expression of ATF4 protein]
|
CTD |
PMID:17645694 PMID:25259610 |
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NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
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G
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Atf6
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activating transcription factor 6
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein] Melatonin inhibits the reaction [Atrazine results in increased cleavage of ATF6 protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ATF6 protein]
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CTD |
PMID:18715270 PMID:25259610 PMID:28070110 PMID:38538260 |
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NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
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G
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Atg12
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autophagy related 12
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multiple interactions
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ISO
|
Melatonin inhibits the reaction [Glyphosate results in increased expression of ATG12 protein]
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CTD |
PMID:33159990 |
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NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261
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G
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Atg5
|
autophagy related 5
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]
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CTD |
PMID:35568058 |
|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
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G
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Atg7
|
autophagy related 7
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]]
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CTD |
PMID:35568058 PMID:36421005 |
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NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319
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G
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Atm
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ATM serine/threonine kinase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of ATM protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ATM mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ATM protein]
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CTD |
PMID:35643323 PMID:36633214 |
|
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
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G
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Atp5f1a
|
ATP synthase F1 subunit alpha
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multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in decreased expression of ATP5F1A protein] Melatonin inhibits the reaction [bisphenol A results in decreased expression of ATP5F1A protein]
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CTD |
PMID:36549428 |
|
NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
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G
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Atp6v1c1
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ATPase H+ transporting V1 subunit C1
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]
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CTD |
PMID:23963992 |
|
NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:71,719,404...71,757,184
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G
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Bace1
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beta-secretase 1
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multiple interactions
|
EXP
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Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of BACE1 protein]
|
CTD |
PMID:33130240 |
|
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
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G
|
Bad
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BCL2-associated agonist of cell death
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multiple interactions increases phosphorylation
|
ISO
|
Melatonin promotes the reaction [YWHAB protein binds to BAD protein] Melatonin results in increased phosphorylation of BAD protein Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased phosphorylation of BAD protein]
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CTD |
PMID:18078454 PMID:21138475 PMID:29763682 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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G
|
Bak1
|
BCL2-antagonist/killer 1
|
multiple interactions
|
ISO EXP
|
[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAK1 mRNA] Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA] Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]
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CTD |
PMID:10965999 PMID:19220725 PMID:23963992 PMID:33962019 |
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NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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G
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Bax
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BCL2 associated X, apoptosis regulator
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decreases expression increases expression multiple interactions
|
ISO EXP
|
Melatonin results in decreased expression of BAX protein Melatonin results in increased expression of BAX mRNA Melatonin inhibits the reaction [Cisplatin results in increased cleavage of BAX protein]; Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]] Melatonin results in increased expression of BAX protein Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]] [Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein; MIR532 promotes the reaction [Melatonin results in increased expression of BAX protein] Melatonin results in increased expression of BAX mRNA; Melatonin results in increased expression of BAX protein
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CTD |
PMID:9649124 PMID:10965999 PMID:14690559 PMID:15683462 PMID:15964511 PMID:16213988 PMID:16499559 PMID:18078454 PMID:18339127 PMID:19220725 PMID:19552762 PMID:20041988 PMID:20333787 PMID:20964710 PMID:21138475 PMID:22526374 PMID:23963992 PMID:24799992 PMID:31330490 PMID:33159990 PMID:33507000 PMID:33962019 PMID:34673010 PMID:35093381 PMID:35367536 PMID:35643323 PMID:36006825 PMID:36154502 PMID:36421005 PMID:36549428 PMID:37755321 PMID:37975621 PMID:38008054 More...
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|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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|
G
|
Bbc3
|
Bcl-2 binding component 3
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BBC3 mRNA] Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BBC3 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of BBC3 protein]
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CTD |
PMID:25259610 PMID:33962019 PMID:35643323 |
|
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
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|
G
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Bcl2
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BCL2, apoptosis regulator
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multiple interactions decreases expression increases expression affects localization
|
ISO EXP
|
[Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]; MIR532 promotes the reaction [Melatonin results in decreased expression of BCL2 protein] Melatonin results in decreased expression of BCL2 mRNA; Melatonin results in decreased expression of BCL2 protein [Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Glyphosate results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Glyphosate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]] Melatonin results in increased expression of BCL2 protein Melatonin affects the localization of BCL2 protein
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CTD |
PMID:9649124 PMID:10965999 PMID:12220328 PMID:14690559 PMID:14993511 PMID:16213988 PMID:16499559 PMID:17645694 PMID:18078454 PMID:18339127 PMID:18715270 PMID:18724894 PMID:19220725 PMID:20041988 PMID:20333787 PMID:21138475 PMID:21244482 PMID:23963992 PMID:24799992 PMID:33159990 PMID:33507000 PMID:33962019 PMID:34673010 PMID:35093381 PMID:35643323 PMID:36154502 PMID:36421005 PMID:36549428 PMID:37755321 PMID:37975621 PMID:38008054 More...
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|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2L1 mRNA] Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]
|
CTD |
PMID:19220725 PMID:21244482 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
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G
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Bcl2l11
|
Bcl2-like 11
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BCL2L11 mRNA]
|
CTD |
PMID:35643323 |
|
NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
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G
|
Bcl2l15
|
Bcl2-like 15
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BCL2L15 mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr 2:194,019,158...194,032,516
Ensembl chr 2:194,027,397...194,032,516
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|
G
|
Bdh2
|
3-hydroxybutyrate dehydrogenase 2
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of BDH2 mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:226,376,356...226,397,006
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|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein] Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]; Melatonin inhibits the reaction [Dietary Fats results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of BDNF mRNA]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]
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CTD |
PMID:29476728 PMID:30372842 PMID:35526705 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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G
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Becn1
|
beclin 1
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multiple interactions increases expression
|
ISO EXP
|
Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein] Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]
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CTD |
PMID:24799992 PMID:35568058 PMID:35598369 PMID:36421005 PMID:37277016 PMID:38229313 More...
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|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
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G
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Bglap
|
bone gamma-carboxyglutamate protein
|
increases expression multiple interactions
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ISO EXP
|
Melatonin results in increased expression of BGLAP mRNA Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of BGLAP mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased secretion of BGLAP protein]
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CTD |
PMID:20738756 PMID:31809235 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
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G
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Bid
|
BH3 interacting domain death agonist
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multiple interactions increases expression
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ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BID mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein] Melatonin results in increased expression of BID protein
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CTD |
PMID:19552762 PMID:33962019 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
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G
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Birc5
|
baculoviral IAP repeat-containing 5
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decreases expression multiple interactions
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ISO EXP
|
Melatonin results in decreased expression of BIRC5 mRNA Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BIRC5 protein] [Doxorubicin co-treated with Melatonin] results in decreased expression of BIRC5 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BIRC5 mRNA]
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CTD |
PMID:33507000 PMID:38229313 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
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|
G
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Bmal1
|
basic helix-loop-helix ARNT like 1
|
multiple interactions
|
EXP
|
Melatonin affects the reaction [Rotenone affects the expression of BMAL1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of BMAL1]
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CTD |
PMID:23085516 PMID:25430725 |
|
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739
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G
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Bmi1
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BMI1 proto-oncogene, polycomb ring finger
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multiple interactions increases expression
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ISO
|
Melatonin affects the reaction [Rotenone affects the phosphorylation of BMI1 protein] Melatonin results in increased expression of BMI1 mRNA
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CTD |
PMID:33157086 |
|
NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024
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|
G
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Bnip3
|
BCL2 interacting protein 3
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multiple interactions increases expression
|
ISO EXP
|
[PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3 mRNA]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein] Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BNIP3 protein] [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]
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CTD |
PMID:31330490 PMID:33962019 PMID:35598369 PMID:37028639 |
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NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
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G
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Bnip3l
|
BCL2 interacting protein 3 like
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3L mRNA]
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CTD |
PMID:33962019 |
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NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282
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G
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Btg2
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BTG anti-proliferation factor 2
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decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of BTG2 mRNA Melatonin inhibits the reaction [Ethanol results in increased expression of BTG2 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]
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CTD |
PMID:28095641 |
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NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
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G
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Calca
|
calcitonin-related polypeptide alpha
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CALCA protein]]
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CTD |
PMID:34146326 |
|
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
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G
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Calm1
|
calmodulin 1
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]
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CTD |
PMID:23963992 |
|
NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381
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G
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Capn1
|
calpain 1
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multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CAPN1 mRNA] Melatonin inhibits the reaction [Atrazine results in increased cleavage of CAPN1 protein]
|
CTD |
PMID:25259610 PMID:30372842 |
|
NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445
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|
G
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Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
[SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased activity of and results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of CASP1 protein]; Melatonin inhibits the reaction [Nickel results in increased expression of CASP1 mRNA] [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP1 protein; Melatonin inhibits the reaction [arsenite results in increased expression of CASP1 protein]
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CTD |
PMID:23963992 PMID:25903262 PMID:36343453 PMID:36504304 PMID:38944328 |
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NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
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G
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Casp12
|
caspase 12
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multiple interactions
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EXP ISO
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[Melatonin co-treated with Aluminum Chloride] results in decreased expression of CASP12 protein; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein] Melatonin inhibits the reaction [bisphenol A results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]
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CTD |
PMID:17645694 PMID:18715270 PMID:28070110 PMID:30910607 PMID:33130240 PMID:34673010 PMID:38538260 More...
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NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
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G
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Casp3
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caspase 3
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multiple interactions increases expression decreases activity increases activity decreases expression
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ISO EXP
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[Doxorubicin co-treated with Melatonin] results in increased expression of CASP3 protein; [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP3 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein] Melatonin results in increased expression of CASP3 protein Melatonin results in decreased activity of CASP3 protein Melatonin results in increased activity of CASP3 protein Melatonin results in decreased expression of CASP3 protein [Melatonin co-treated with Thioacetamide] results in increased expression of CASP3 protein; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of and results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]] Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Glyphosate results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Radon results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]
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CTD |
PMID:12220328 PMID:12880480 PMID:15683462 PMID:15800915 PMID:15964511 PMID:16879318 PMID:17602819 PMID:17645694 PMID:17910606 PMID:18571630 PMID:18715270 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20333787 PMID:21244482 PMID:21431366 PMID:22526374 PMID:25259610 PMID:25454643 PMID:25903262 PMID:29763682 PMID:29966675 PMID:30372842 PMID:30404999 PMID:31330490 PMID:31967703 PMID:33107683 PMID:33146023 PMID:33159990 PMID:33962019 PMID:34673010 PMID:35367536 PMID:35526705 PMID:35598369 PMID:36006825 PMID:36421005 PMID:36549428 PMID:36890697 PMID:37975621 PMID:38229313 PMID:38538260 More...
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Casp8
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caspase 8
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multiple interactions
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ISO EXP
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Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein] Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP8 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein] Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]
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CTD |
PMID:21431366 PMID:25259610 PMID:25454643 PMID:33962019 PMID:35844137 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
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G
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Casp9
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caspase 9
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multiple interactions increases activity
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ISO EXP
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Melatonin inhibits the reaction [bisphenol A results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein] Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [bisphenol A results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP9 protein modified form]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]] Melatonin results in increased activity of CASP9 protein Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of CASP9 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]
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CTD |
PMID:19220725 PMID:19552762 PMID:20130848 PMID:20964710 PMID:21431366 PMID:23963992 PMID:29763682 PMID:30404999 PMID:30910607 PMID:33146023 PMID:35093381 PMID:35367536 PMID:36006825 PMID:36421005 PMID:36549428 More...
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Ensembl chr 5:159,391,188...159,409,648
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G
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Cat
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catalase
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multiple interactions increases activity increases expression decreases activity
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ISO EXP
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[aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein] Melatonin results in increased expression of CAT mRNA [Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein] Melatonin results in decreased activity of CAT protein [aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
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CTD |
PMID:9194422 PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 PMID:16703270 PMID:16931443 PMID:17195641 PMID:19405147 PMID:19539013 PMID:19680607 PMID:19961921 PMID:20556922 PMID:22013727 PMID:22526374 PMID:23374533 PMID:23554006 PMID:24318767 PMID:24733834 PMID:26286521 PMID:28803342 PMID:29763682 PMID:31931096 PMID:33159990 PMID:36633214 PMID:37277016 PMID:37348669 PMID:37598416 PMID:38229313 PMID:38440074 More...
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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G
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Cck
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cholecystokinin
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increases secretion
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EXP
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Melatonin results in increased secretion of CCK protein
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CTD |
PMID:15009505 |
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NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
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G
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Ccl2
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C-C motif chemokine ligand 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
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CTD |
PMID:22225513 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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G
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Ccl5
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C-C motif chemokine ligand 5
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA]
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CTD |
PMID:22225513 PMID:31330490 |
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NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
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G
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Ccn1
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cellular communication network factor 1
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of CCN1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of CCN1 protein]
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CTD |
PMID:36154502 |
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NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
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G
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Ccn2
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cellular communication network factor 2
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of CCN2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of CCN2 protein]
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CTD |
PMID:36154502 |
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NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
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G
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Ccna1
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cyclin A1
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multiple interactions
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ISO
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Melatonin affects the reaction [Manganese affects the expression of CCNA1 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CCNA1 protein]]
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CTD |
PMID:38563506 |
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NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300
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G
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Ccnb1
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cyclin B1
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decreases expression multiple interactions
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ISO
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Melatonin results in decreased expression of CCNB1 mRNA; Melatonin results in decreased expression of CCNB1 protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of CCNB1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CCNB1 protein] Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of CCNB1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CCNB1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CCNB1 protein]
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CTD |
PMID:21108658 PMID:35643323 PMID:36633214 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
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G
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Ccnd1
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cyclin D1
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decreases expression multiple interactions
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ISO
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Melatonin results in decreased expression of CCND1 mRNA; Melatonin results in decreased expression of CCND1 protein Melatonin affects the reaction [Manganese affects the expression of CCND1 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CCND1 protein]]
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CTD |
PMID:21108658 PMID:38563506 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
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G
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Ccne1
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cyclin E1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of CCNE1 mRNA]
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CTD |
PMID:36633214 |
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NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
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G
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Ccr7
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C-C motif chemokine receptor 7
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 protein]
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CTD |
PMID:36265525 |
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NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501
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G
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Cd14
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CD14 molecule
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multiple interactions
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EXP
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Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CD14 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]
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CTD |
PMID:28238930 |
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NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292
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G
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Cd200
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Cd200 molecule
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decreases expression
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ISO
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Melatonin results in decreased expression of CD200 protein
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CTD |
PMID:27503577 |
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NCBI chr11:68,916,200...68,943,570
Ensembl chr11:68,916,224...68,943,569
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G
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Cd36
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CD36 molecule
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CD36 mRNA]
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CTD |
PMID:21689150 |
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NCBI chr 4:18,209,088...18,302,142
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G
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Cdk1
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cyclin-dependent kinase 1
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decreases expression multiple interactions
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ISO
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Melatonin results in decreased expression of CDK1 mRNA; Melatonin results in decreased expression of CDK1 protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDK1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDK1 protein] Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDK1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDK1 protein]
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CTD |
PMID:21108658 PMID:35643323 PMID:36633214 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
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G
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Cdk2
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cyclin dependent kinase 2
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multiple interactions
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ISO
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Melatonin affects the reaction [Manganese affects the expression of CDK2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK2 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDK2 protein]]
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CTD |
PMID:23963992 PMID:35643323 PMID:38563506 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
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G
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Cdk4
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cyclin-dependent kinase 4
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decreases expression multiple interactions
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ISO
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Melatonin results in decreased expression of CDK4 mRNA; Melatonin results in decreased expression of CDK4 protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDK4 mRNA]
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CTD |
PMID:21108658 PMID:36633214 |
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NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
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G
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Cdk6
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cyclin-dependent kinase 6
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of CDK6 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of CDK6 protein]
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CTD |
PMID:36633214 |
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NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
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G
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Cdkn1a
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cyclin-dependent kinase inhibitor 1A
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increases expression multiple interactions
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ISO
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Melatonin results in increased expression of CDKN1A protein Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Melatonin inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
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CTD |
PMID:12071473 PMID:18384530 PMID:29330934 PMID:29734669 PMID:33962019 PMID:38000455 More...
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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G
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Cdkn1b
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cyclin-dependent kinase inhibitor 1B
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1B mRNA] Melatonin affects the reaction [Manganese affects the expression of CDKN1B protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDKN1B protein]]
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CTD |
PMID:33962019 PMID:38563506 |
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NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
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G
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Cdkn1c
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cyclin-dependent kinase inhibitor 1C
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multiple interactions
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ISO
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Melatonin affects the reaction [Manganese affects the expression of CDKN1C protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDKN1C protein]]
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CTD |
PMID:38563506 |
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NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498
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G
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Cdkn2a
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cyclin-dependent kinase inhibitor 2A
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein]
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CTD |
PMID:34673010 |
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NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
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G
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Cebpb
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CCAAT/enhancer binding protein beta
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multiple interactions
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ISO
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CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein] Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CEBPB protein]
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CTD |
PMID:34973135 PMID:38008054 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
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G
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Chek1
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checkpoint kinase 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of CHEK1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of CHEK1 protein]
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CTD |
PMID:36633214 |
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NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359
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G
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Chek2
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checkpoint kinase 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of CHEK2 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of CHEK2 protein]
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CTD |
PMID:36633214 |
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NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667
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G
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Cish
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cytokine inducible SH2-containing protein
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multiple interactions decreases expression
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ISO
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[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA] Melatonin results in decreased expression of CISH mRNA
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CTD |
PMID:21461237 |
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NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986
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G
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Ckb
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creatine kinase B
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CKB protein]
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CTD |
PMID:19389042 |
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NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478
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G
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Clec4a
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C-type lectin domain family 4, member A
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multiple interactions decreases expression
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC4N mRNA] Melatonin results in decreased expression of CLEC4N mRNA
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CTD |
PMID:21461237 |
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NCBI chr 4:158,026,138...158,119,904
Ensembl chr 4:158,100,615...158,118,094
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G
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Clec4a3
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C-type lectin domain family 4, member A3
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increases expression multiple interactions
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ISO
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Melatonin results in increased expression of CLEC4A3 mRNA Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC4A3 mRNA]
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CTD |
PMID:21461237 |
|
NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:157,885,895...157,896,727
|
|
G
|
Clock
|
clock circadian regulator
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK]
|
CTD |
PMID:23085516 |
|
NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]
|
CTD |
PMID:38000455 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
|
|
G
|
Colec12
|
collectin sub-family member 12
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with Melatonin] results in increased expression of COLEC12 mRNA
|
CTD |
PMID:21461237 |
|
NCBI chr18:1,005,787...1,193,455
Ensembl chr18:1,005,741...1,195,297
|
|
G
|
Cox4i1
|
cytochrome c oxidase subunit 4i1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein]
|
CTD |
PMID:30910607 |
|
NCBI chr19:48,721,680...48,727,920
Ensembl chr19:65,630,432...65,636,624
|
|
G
|
Cox6b1
|
cytochrome c oxidase subunit 6B1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:95,002,513...95,011,516
Ensembl chr 1:95,001,707...95,011,431 Ensembl chr 5:95,001,707...95,011,431
|
|
G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
G
|
Cry1
|
cryptochrome circadian regulator 1
|
multiple interactions
|
EXP
|
Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]; Melatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA]
|
CTD |
PMID:23085516 PMID:25430725 |
|
NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822
|
|
G
|
Cry2
|
cryptochrome circadian regulator 2
|
affects expression multiple interactions
|
EXP
|
Melatonin affects the expression of CRY2 mRNA Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]; Melatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]
|
CTD |
PMID:21442002 PMID:23085516 PMID:25430725 |
|
NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:98,830,483...98,860,447
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; MIR532 promotes the reaction [Melatonin results in decreased expression of CTNNB1 protein] Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of CTNNB1 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CTNNB1 protein]
|
CTD |
PMID:26990689 PMID:31809235 PMID:35526705 PMID:37755321 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
|
|
G
|
Ctnnd1
|
catenin delta 1
|
multiple interactions decreases expression
|
ISO
|
MIR532 promotes the reaction [Melatonin results in decreased expression of CTNND1 protein]
|
CTD |
PMID:37755321 |
|
NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:90,090,564...90,141,189
|
|
G
|
Ctsb
|
cathepsin B
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein]
|
CTD |
PMID:21392095 |
|
NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
|
|
G
|
Ctsd
|
cathepsin D
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD]
|
CTD |
PMID:22041583 |
|
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
|
|
G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
multiple interactions decreases expression
|
ISO
|
[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CXCL10 mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA] Melatonin results in decreased expression of CXCL10 mRNA
|
CTD |
PMID:21461237 |
|
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
|
|
G
|
Cyba
|
cytochrome b-245 alpha chain
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of CYBA mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214
|
|
G
|
Cybb
|
cytochrome b-245 beta chain
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of CYBB mRNA]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA] [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of CYBB mRNA] Melatonin results in decreased expression of CYBB mRNA Melatonin inhibits the reaction [Galactose results in increased expression of CYBB protein]
|
CTD |
PMID:31330490 PMID:34673010 PMID:36504304 PMID:36633214 |
|
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065
|
|
G
|
Cycs
|
cytochrome c, somatic
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CYCS mRNA] Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]
|
CTD |
PMID:33962019 PMID:36421005 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
|
|
G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 protein]
|
CTD |
PMID:38440074 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
|
|
G
|
Cyp17a1
|
cytochrome P450, family 17, subfamily a, polypeptide 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of CYP17A1 protein]
|
CTD |
PMID:38440074 PMID:38538260 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
|
|
G
|
Cyp19a1
|
cytochrome P450, family 19, subfamily a, polypeptide 1
|
decreases expression multiple interactions decreases activity
|
ISO EXP
|
Melatonin results in decreased expression of CYP19A1 [Melatonin co-treated with ortho-topolin riboside] results in decreased expression of CYP19A1 mRNA Melatonin results in decreased activity of CYP19A1 protein
|
CTD |
PMID:16080194 PMID:38325522 |
|
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions decreases activity increases hydroxylation
|
EXP ISO
|
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA] [Melatonin co-treated with ortho-topolin riboside] results in decreased expression of CYP1A1 mRNA Melatonin results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased hydroxylation of Melatonin
|
CTD |
PMID:15616152 PMID:19919601 PMID:20033131 PMID:38325522 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
decreases methylation multiple interactions increases metabolic processing increases hydroxylation affects metabolic processing decreases activity
|
ISO EXP
|
CYP1A2 protein results in decreased methylation of Melatonin [ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin] CYP1A2 protein results in increased hydroxylation of Melatonin CYP1A2 protein affects the metabolism of Melatonin [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA Melatonin results in decreased activity of CYP1A2 protein Melatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]
|
CTD |
PMID:15616152 PMID:15626586 PMID:15824912 PMID:17565714 PMID:19919601 PMID:20033131 PMID:22634058 PMID:25623066 More...
|
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions decreases activity increases hydroxylation
|
ISO
|
2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin] Melatonin results in decreased activity of CYP1B1 protein
|
CTD |
PMID:15616152 PMID:19919601 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
G
|
Cyp27a1
|
cytochrome P450, family 27, subfamily a, polypeptide 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA]
|
CTD |
PMID:28095641 |
|
NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
|
|
G
|
Cyp2b2
|
cytochrome P450, family 2, subfamily b, polypeptide 2
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]
|
CTD |
PMID:20033131 |
|
NCBI chr 1:90,722,243...90,736,272
|
|
G
|
Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
increases hydroxylation decreases methylation
|
ISO
|
CYP2C19 protein results in increased hydroxylation of Melatonin CYP2C19 protein results in decreased methylation of Melatonin
|
CTD |
PMID:15616152 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein] Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
|
CTD |
PMID:20338863 PMID:20964710 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of CYP7A1 mRNA Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]
|
CTD |
PMID:28095641 |
|
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
|
|
G
|
Cyp8b1
|
cytochrome P450 family 8 subfamily B member 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA]
|
CTD |
PMID:28095641 |
|
NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689
|
|
G
|
Dap3
|
death associated protein 3
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:176,617,155...176,644,270
|
|
G
|
Ddah1
|
dimethylarginine dimethylaminohydrolase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH1 protein]
|
CTD |
PMID:36890697 |
|
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:237,327,766...237,460,626
|
|
G
|
Ddah2
|
DDAH family member 2, ADMA-independent
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH2 protein]
|
CTD |
PMID:36890697 |
|
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,766,120...3,769,183
|
|
G
|
Ddc
|
dopa decarboxylase
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of DDC mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of DDIT3 protein] Melatonin inhibits the reaction [Atrazine results in increased expression of DDIT3 protein]
|
CTD |
PMID:18715270 PMID:25259610 PMID:28070110 PMID:33130240 PMID:34673010 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Diablo
|
diablo, IAP-binding mitochondrial protein
|
increases expression multiple interactions
|
ISO
|
Melatonin results in increased expression of DIABLO mRNA; Melatonin results in increased expression of DIABLO protein [Doxorubicin co-treated with Melatonin] results in increased expression of DIABLO protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of DIABLO mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DIABLO mRNA]
|
CTD |
PMID:33507000 PMID:33962019 |
|
NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265
|
|
G
|
Dio2
|
iodothyronine deiodinase 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate affects the expression of DIO2 mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594
|
|
G
|
Disc1
|
DISC1 scaffold protein
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of DISC1 mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970
|
|
G
|
Dmgdh
|
dimethylglycine dehydrogenase
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in increased expression of DMGDH mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr 2:26,647,540...26,722,496
Ensembl chr 2:26,647,565...26,723,071
|
|
G
|
Dnm1l
|
dynamin 1-like
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of DNM1L protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein] Melatonin inhibits the reaction [bisphenol A results in increased expression of DNM1L protein] Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DNM1L mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of DNM1L protein]; Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]
|
CTD |
PMID:26882442 PMID:29183837 PMID:29966675 PMID:33962019 PMID:36549428 |
|
NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420
|
|
G
|
Dnm2
|
dynamin 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:28,254,529...28,336,295
|
|
G
|
Drd1
|
dopamine receptor D1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein]
|
CTD |
PMID:24969583 |
|
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
|
|
G
|
Drd2
|
dopamine receptor D2
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein] Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]
|
CTD |
PMID:18289173 PMID:24969583 |
|
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
|
|
G
|
E2f1
|
E2F transcription factor 1
|
multiple interactions
|
ISO
|
Melatonin affects the reaction [Manganese affects the expression of E2F1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of E2F1 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of E2F1 protein]]
|
CTD |
PMID:23963992 PMID:25259610 PMID:38563506 |
|
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
|
|
G
|
Echs1
|
enoyl-CoA hydratase, short chain 1
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ECHS1 mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506
|
|
G
|
Eef1g
|
eukaryotic translation elongation factor 1 gamma
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479
|
|
G
|
Egf
|
epidermal growth factor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]
|
CTD |
PMID:36343453 |
|
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
|
|
G
|
Ehmt2
|
euchromatic histone lysine methyltransferase 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of EHMT2 protein]
|
CTD |
PMID:37994397 |
|
NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384
|
|
G
|
Eif2a
|
eukaryotic translation initiation factor 2A
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2A protein]
|
CTD |
PMID:38538260 |
|
NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201
|
|
G
|
Eif2ak3
|
eukaryotic translation initiation factor 2 alpha kinase 3
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2AK3 protein]
|
CTD |
PMID:28070110 PMID:34673010 PMID:38538260 |
|
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
|
|
G
|
Eif2s1
|
eukaryotic translation initiation factor 2 subunit alpha
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]
|
CTD |
PMID:28070110 |
|
NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
|
|
G
|
Eif4ebp1
|
eukaryotic translation initiation factor 4E binding protein 1
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
|
CTD |
PMID:19054297 |
|
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874
|
|
G
|
Eif4g2
|
eukaryotic translation initiation factor 4, gamma 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:174,616,102...174,628,252
Ensembl chr 1:174,616,103...174,628,252
|
|
G
|
Elk1
|
ETS transcription factor ELK1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249
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|
G
|
Eno2
|
enolase 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein]
|
CTD |
PMID:24969583 |
|
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220
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G
|
Ercc1
|
ERCC excision repair 1, endonuclease non-catalytic subunit
|
increases expression
|
ISO
|
Melatonin results in increased expression of ERCC1 protein
|
CTD |
PMID:24799992 |
|
NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:88,118,891...88,139,120
|
|
G
|
Ern1
|
endoplasmic reticulum to nucleus signaling 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]; Melatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein] Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of ERN1 protein]
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CTD |
PMID:20136702 PMID:28070110 PMID:38538260 |
|
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
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|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] Melatonin results in decreased expression of ESR1 mRNA Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein [Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA]
|
CTD |
PMID:15813899 PMID:16030176 PMID:16051031 PMID:16635015 PMID:23591044 PMID:26990689 PMID:27551335 More...
|
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions decreases expression
|
EXP
|
[Melatonin co-treated with Ethanol] results in increased expression of ESR2 protein; Ethanol inhibits the reaction [Melatonin results in decreased expression of ESR2 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of ESR2 protein]
|
CTD |
PMID:23591044 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
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|
G
|
Fabp4
|
fatty acid binding protein 4
|
decreases expression
|
ISO
|
Melatonin results in decreased expression of FABP4 mRNA
|
CTD |
PMID:20738756 |
|
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
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|
G
|
Fas
|
Fas cell surface death receptor
|
multiple interactions decreases expression
|
EXP ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein] Melatonin results in decreased expression of FAS mRNA; Melatonin results in decreased expression of FAS protein Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of FAS protein]
|
CTD |
PMID:14993511 PMID:20181888 PMID:23963992 PMID:25259610 PMID:25454643 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
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|
G
|
Faslg
|
Fas ligand
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein] Melatonin inhibits the reaction [Atrazine results in increased expression of FASL protein]
|
CTD |
PMID:14993511 PMID:25259610 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
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|
G
|
Fasn
|
fatty acid synthase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FASN mRNA]
|
CTD |
PMID:21689150 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
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|
G
|
Fcgr2b
|
Fc gamma receptor 2B
|
multiple interactions decreases expression
|
ISO
|
Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA] Melatonin results in decreased expression of FCGR2B mRNA
|
CTD |
PMID:21461237 |
|
NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517
|
|
G
|
Fen1
|
flap structure-specific endonuclease 1
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in increased expression of FEN1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016
|
|
G
|
Fgf9
|
fibroblast growth factor 9
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]; Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein]
|
CTD |
PMID:19476551 |
|
NCBI chr15:36,325,552...36,369,995
Ensembl chr15:36,325,599...36,367,926
|
|
G
|
Fis1
|
fission, mitochondrial 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein] Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of FIS1 mRNA]
|
CTD |
PMID:29966675 PMID:33962019 |
|
NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335
|
|
G
|
Fn1
|
fibronectin 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]
|
CTD |
PMID:19524604 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Capsaicin results in increased expression of FOS protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of FOS protein]
|
CTD |
PMID:19172228 PMID:28238930 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Fshb
|
follicle stimulating hormone subunit beta
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of FSHB protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of FSHB protein]
|
CTD |
PMID:23591044 PMID:36154502 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
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|
G
|
Fundc1
|
FUN14 domain containing 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr X:5,083,635...5,100,293
Ensembl chr X:7,666,759...7,683,441
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|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
increases activity multiple interactions
|
EXP ISO
|
Melatonin results in increased activity of G6PD protein Melatonin inhibits the reaction [sodium arsenite results in decreased expression of G6PD protein] [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein
|
CTD |
PMID:16224550 PMID:25903262 PMID:29763682 |
|
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144
|
|
G
|
Gap43
|
growth associated protein 43
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein]
|
CTD |
PMID:19409439 |
|
NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797
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|
G
|
Gast
|
gastrin
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multiple interactions increases expression
|
EXP
|
luzindole inhibits the reaction [Melatonin results in increased expression of GAST]
|
CTD |
PMID:12074098 PMID:16207293 |
|
NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880
|
|
G
|
Gcat
|
glycine C-acetyltransferase
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of GCAT mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr 7:112,475,572...112,481,920
Ensembl chr 7:112,475,496...112,482,664
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
ISO
|
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]
|
CTD |
PMID:25550330 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]
|
CTD |
PMID:25550330 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GFAP protein] Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]
|
CTD |
PMID:17572393 PMID:25288107 PMID:34673010 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
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|
G
|
Ggt1
|
gamma-glutamyltransferase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein]
|
CTD |
PMID:15700767 |
|
NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050
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|
G
|
Glb1
|
galactosidase, beta 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glucose results in increased expression of GLB1 protein]
|
CTD |
PMID:38000455 |
|
NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326
|
|
G
|
Gnrh1
|
gonadotropin releasing hormone 1
|
multiple interactions
|
EXP
|
Melatonin promotes the reaction [bisphenol A results in increased expression of GNRH1 mRNA]
|
CTD |
PMID:33967032 |
|
NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977 Ensembl chr15:46,148,301...46,148,977
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|
G
|
Gnrhr
|
gonadotropin releasing hormone receptor
|
increases expression multiple interactions
|
EXP
|
Melatonin results in increased expression of GNRHR mRNA [bisphenol A co-treated with Melatonin] results in increased expression of GNRHR mRNA
|
CTD |
PMID:33967032 |
|
NCBI chr14:22,211,666...22,229,654
|
|
G
|
Got1
|
glutamic-oxaloacetic transaminase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Capecitabine results in increased expression of GOT1 protein]
|
CTD |
PMID:38179616 |
|
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP
|
[Melatonin co-treated with Thioacetamide] results in increased expression of GPT protein; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein]; Melatonin inhibits the reaction [Capecitabine results in increased expression of GPT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of GPT protein]; Melatonin inhibits the reaction [Monocrotaline results in increased expression of GPT protein]
|
CTD |
PMID:15700767 PMID:26882442 PMID:31967703 PMID:36890697 PMID:37350538 PMID:38179616 PMID:38229313 More...
|
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions increases expression
|
EXP ISO
|
[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein] Melatonin results in increased expression of GPX1 mRNA
|
CTD |
PMID:15589378 PMID:25288107 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
|
|
G
|
Gpx2
|
glutathione peroxidase 2
|
multiple interactions
|
EXP
|
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA
|
CTD |
PMID:20033131 |
|
NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862
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|
G
|
Gpx3
|
glutathione peroxidase 3
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in increased expression of GPX3 mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405
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|
G
|
Gpx4
|
glutathione peroxidase 4
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]] Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of GPX4 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of GPX4 protein]
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CTD |
PMID:35093381 PMID:37975621 |
|
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
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G
|
Grb2
|
growth factor receptor bound protein 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138
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|
G
|
Grin1
|
glutamate ionotropic receptor NMDA type subunit 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Galactose results in increased expression of GRIN1 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754
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|
G
|
Grin2b
|
glutamate ionotropic receptor NMDA type subunit 2B
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Galactose results in increased expression of GRIN2B protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
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|
G
|
Gsdmd
|
gasdermin D
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Cadmium results in increased cleavage of GSDMD protein]
|
CTD |
PMID:38944328 |
|
NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722
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G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form] Melatonin results in decreased expression of GSK3B protein MIR532 promotes the reaction [Melatonin results in decreased expression of GSK3B protein] Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of GSK3B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]
|
CTD |
PMID:15842767 PMID:31809235 PMID:35526705 PMID:37755321 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
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|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions increases activity decreases expression
|
EXP ISO
|
[Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; aluminum lactate affects the reaction [Melatonin results in increased activity of GSR protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased activity of GSR protein] [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of GSR protein Melatonin results in decreased expression of GSR protein [aluminum lactate co-treated with Melatonin] results in increased expression of GSR mRNA; aluminum lactate promotes the reaction [Melatonin results in decreased expression of GSR protein]; luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased expression of GSR protein] Melatonin results in decreased expression of GSR mRNA
|
CTD |
PMID:12823611 PMID:16098089 PMID:16224550 PMID:16931443 PMID:19405147 PMID:19680607 PMID:21442002 PMID:21840368 PMID:22526374 PMID:23554006 PMID:24969583 PMID:25288107 PMID:25903262 PMID:29763682 More...
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|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
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|
G
|
Gsta4
|
glutathione S-transferase alpha 4
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]
|
CTD |
PMID:20964710 |
|
NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488
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G
|
Gsta5
|
glutathione S-transferase alpha 5
|
multiple interactions
|
EXP
|
[Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
|
CTD |
PMID:20033131 |
|
NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765
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G
|
Gstm1
|
glutathione S-transferase mu 1
|
multiple interactions
|
EXP
|
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA
|
CTD |
PMID:20033131 |
|
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
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|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA] Melatonin affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA]
|
CTD |
PMID:21986892 PMID:23963992 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
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|
G
|
H19
|
H19 imprinted maternally expressed transcript
|
increases expression
|
EXP
|
monocrotaline increases expression of H19 RNA in pulmonary artery smooth muscle cells
|
RGD |
PMID:30240970 |
RGD:156430315 |
NCBI chr 1:207,160,175...207,162,851
|
|
G
|
H2ax
|
H2A.X variant histone
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in increased phosphorylation of H2AX protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein]; Melatonin inhibits the reaction [Cadmium results in increased expression of H2AX protein]
|
CTD |
PMID:35643323 PMID:37994397 PMID:38944328 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
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|
G
|
Havcr1
|
hepatitis A virus cellular receptor 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [sodium arsenite results in increased expression of HAVCR1 protein]
|
CTD |
PMID:29763682 |
|
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
|
|
G
|
Hdac3
|
histone deacetylase 3
|
multiple interactions decreases activity
|
ISO
|
CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
|
CTD |
PMID:34973135 |
|
NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025
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|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Hmgb1
|
high mobility group box 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [decabromobiphenyl ether affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein] Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMGB1 mRNA]
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CTD |
PMID:27413111 PMID:35844137 PMID:36566971 |
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NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
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G
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Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression decreases expression
|
EXP ISO
|
Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Tenofovir results in decreased expression of HMOX1 protein]; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein] [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of HMOX1 mRNA]] Melatonin results in increased expression of HMOX1 protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Melatonin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA] Melatonin results in decreased expression of HMOX1 mRNA
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CTD |
PMID:10942521 PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 PMID:20197452 PMID:20433640 PMID:21442002 PMID:21986892 PMID:25288107 PMID:27871981 PMID:30372842 PMID:33146023 PMID:34146326 PMID:35598369 PMID:36549428 PMID:37598416 PMID:37975621 PMID:37994397 PMID:38229313 More...
|
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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G
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Hmox2
|
heme oxygenase 2
|
multiple interactions decreases expression
|
EXP
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[Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] Melatonin results in decreased expression of HMOX2 mRNA
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CTD |
PMID:21442002 PMID:21986892 |
|
NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800
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G
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Hsd17b3
|
hydroxysteroid (17-beta) dehydrogenase 3
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of HSD17B3 protein]
|
CTD |
PMID:38538260 |
|
NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283
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G
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Hsf1
|
heat shock transcription factor 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
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G
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Hsp90aa1
|
heat shock protein 90 alpha family class A member 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499
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G
|
Hsp90b1
|
heat shock protein 90 beta family member 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of HSP90B1 protein]
|
CTD |
PMID:38538260 |
|
NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293
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G
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Hspa1a
|
heat shock protein family A (Hsp70) member 1A
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA]
|
CTD |
PMID:31330490 |
|
NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979
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G
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Hspa5
|
heat shock protein family A (Hsp70) member 5
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of HSPA5 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein] Melatonin inhibits the reaction [bisphenol A results in increased expression of HSPA5 protein]
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CTD |
PMID:20136702 PMID:28070110 PMID:33130240 PMID:34673010 PMID:38538260 |
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NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
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|
G
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Hspa9
|
heat shock protein family A (Hsp70) member 9
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multiple interactions
|
EXP
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Melatonin affects the reaction [Mercuric Chloride results in increased expression of HSPA9 protein]
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CTD |
PMID:16801527 |
|
NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398
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G
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Ifng
|
interferon gamma
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multiple interactions
|
ISO EXP
|
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IFNG protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA] [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]
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CTD |
PMID:16373423 PMID:23374533 PMID:23963992 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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G
|
Igf1
|
insulin-like growth factor 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
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G
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Igf1r
|
insulin-like growth factor 1 receptor
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decreases expression
|
EXP
|
melatonin decreases expression of Igf1r RNA in pulmonary artery smooth muscle cells
|
RGD |
PMID:30240970 |
RGD:156430315 |
NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664
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|
G
|
Il10
|
interleukin 10
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multiple interactions
|
ISO EXP
|
[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL10 protein]; IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 protein] Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of IL10 protein]
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CTD |
PMID:16373423 PMID:36566971 PMID:37269891 PMID:37598416 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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|
G
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Il11
|
interleukin 11
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Dextran Sulfate results in decreased expression of IL11 protein]
|
CTD |
PMID:36265525 |
|
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915
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|
G
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Il13
|
interleukin 13
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Dibutyl Phthalate promotes the reaction [OVAL results in increased expression of IL13 protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]
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CTD |
PMID:32446102 PMID:34146326 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
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G
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Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [Dibutyl Phthalate promotes the reaction [OVAL results in increased expression of IL17A protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A protein]]
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CTD |
PMID:32446102 PMID:34146326 PMID:37269891 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
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|
G
|
Il18
|
interleukin 18
|
multiple interactions
|
ISO
|
Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of IL18 mRNA] Melatonin inhibits the reaction [arsenite results in increased expression of and results in increased secretion of IL18 protein]
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CTD |
PMID:36343453 PMID:36504304 |
|
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
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|
G
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Il1a
|
interleukin 1 alpha
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multiple interactions decreases expression
|
ISO
|
Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1A protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] Melatonin results in decreased expression of IL1A mRNA
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CTD |
PMID:21461237 PMID:36265525 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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G
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Il1b
|
interleukin 1 beta
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multiple interactions decreases secretion decreases expression
|
ISO EXP
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[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL1B protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Nickel results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]] melatonin inhibits the reaction [methamphetamine increases expression of IL1b mRNA in rat microglial cell lines] Melatonin inhibits the reaction [arsenite results in increased expression of and results in increased secretion of IL1B protein] Melatonin results in decreased secretion of IL1B protein Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]] Melatonin results in decreased expression of IL1B mRNA; Melatonin results in decreased expression of IL1B protein
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CTD RGD |
PMID:15714805 PMID:16373423 PMID:19028472 PMID:20374443 PMID:21461237 PMID:23963992 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30372842 PMID:30595364 PMID:35526705 PMID:35844137 PMID:36265525 PMID:36343453 PMID:36421005 PMID:36504304 PMID:36566971 PMID:37028639 PMID:37598416 PMID:38944328 PMID:20374443 More...
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RGD:598147057 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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G
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Il2
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interleukin 2
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increases activity multiple interactions
|
ISO
|
Melatonin results in increased activity of IL2 protein Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL2 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]
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CTD |
PMID:9730580 PMID:16373423 PMID:36421005 |
|
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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G
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Il23a
|
interleukin 23 subunit alpha
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multiple interactions
|
ISO
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Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein]
|
CTD |
PMID:36265525 |
|
NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434
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G
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Il4
|
interleukin 4
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Dibutyl Phthalate promotes the reaction [OVAL results in increased expression of IL4 protein]]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL4 protein]]
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CTD |
PMID:27871981 PMID:32446102 PMID:34146326 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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G
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Il5
|
interleukin 5
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Dibutyl Phthalate promotes the reaction [OVAL results in increased expression of IL5 protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 protein]]
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CTD |
PMID:32446102 PMID:34146326 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
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G
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Il6
|
interleukin 6
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multiple interactions decreases secretion
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EXP ISO
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Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 protein] melatonin inhibits the reaction [methamphetamine increases expression of IL6 mRNA in rat microglial cell lines] Melatonin results in decreased secretion of IL6 protein Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL6 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Cadmium results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]
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CTD RGD |
PMID:16373423 PMID:20374443 PMID:21158907 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30595364 PMID:32554039 PMID:35844137 PMID:36265525 PMID:36421005 PMID:37598416 PMID:38944328 PMID:20374443 More...
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RGD:598147057 |
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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G
|
Il7
|
interleukin 7
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]]
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CTD |
PMID:36421005 |
|
NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389
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G
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Ins1
|
insulin 1
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multiple interactions
|
EXP
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Melatonin affects the reaction [Streptozocin results in decreased expression of INS1 protein]; Melatonin inhibits the reaction [Colforsin results in increased secretion of INS1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]]
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CTD |
PMID:12153439 PMID:17198541 PMID:32554039 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
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G
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Insr
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insulin receptor
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]
|
CTD |
PMID:19705549 |
|
NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803
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G
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Irs1
|
insulin receptor substrate 1
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein]
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CTD |
PMID:29763682 |
|
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
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G
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Irs2
|
insulin receptor substrate 2
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543
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G
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Itpr1
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inositol 1,4,5-trisphosphate receptor, type 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504
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G
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Itpr3
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inositol 1,4,5-trisphosphate receptor, type 3
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Galactose results in increased expression of ITPR3 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184
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G
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Izumo1r
|
IZUMO1 receptor, JUNO
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A affects the expression of and affects the localization of IZUMO1R protein]; Melatonin inhibits the reaction [Ethinyl Estradiol affects the localization of IZUMO1R protein]
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CTD |
PMID:28178360 PMID:31931096 |
|
NCBI chr 8:11,744,384...11,748,131
Ensembl chr 8:20,025,831...20,029,578
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G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of JUN protein]
|
CTD |
PMID:28238930 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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|
G
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Kdr
|
kinase insert domain receptor
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of KDR mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
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|
G
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Keap1
|
Kelch-like ECH-associated protein 1
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of KEAP1 protein Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]
|
CTD |
PMID:25288107 |
|
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
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|
G
|
Kl
|
Klotho
|
multiple interactions
|
ISO
|
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]
|
CTD |
PMID:25550330 |
|
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015
|
|
G
|
Lamp2
|
lysosomal-associated membrane protein 2
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of LAMP2 protein]
|
CTD |
PMID:26882442 |
|
NCBI chr X:122,038,734...122,087,745
Ensembl chr X:121,922,187...122,087,675
|
|
G
|
Lats1
|
large tumor suppressor kinase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of and results in increased phosphorylation of LATS1 protein]
|
CTD |
PMID:36154502 |
|
NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029
|
|
G
|
Lep
|
leptin
|
decreases expression
|
ISO EXP
|
Melatonin results in decreased expression of LEP mRNA Melatonin results in decreased expression of LEP protein
|
CTD |
PMID:19028472 PMID:20738756 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
|
|
G
|
Lhb
|
luteinizing hormone subunit beta
|
multiple interactions
|
EXP
|
[Melatonin co-treated with LHB protein] results in increased chemical synthesis of Testosterone; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of LHB]; Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of LHB protein]
|
CTD |
PMID:16054318 PMID:23085516 PMID:36154502 |
|
NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
|
|
G
|
Lhcgr
|
luteinizing hormone/choriogonadotropin receptor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of LHCGR protein]
|
CTD |
PMID:38440074 |
|
NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061
|
|
G
|
Lig1
|
DNA ligase 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of LIG1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:83,219,545...83,281,708
|
|
G
|
Lig3
|
DNA ligase 3
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of LIG3 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr10:68,215,371...68,238,705
Ensembl chr10:68,215,407...68,238,704
|
|
G
|
Lig4
|
DNA ligase 4
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in increased expression of LIG4 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926
|
|
G
|
Lpl
|
lipoprotein lipase
|
decreases expression
|
ISO
|
Melatonin results in decreased expression of LPL mRNA
|
CTD |
PMID:20738756 |
|
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
|
|
G
|
Lrp1
|
LDL receptor related protein 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of LRP1 protein]
|
CTD |
PMID:33130240 |
|
NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196
|
|
G
|
Ly96
|
lymphocyte antigen 96
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]
|
CTD |
PMID:27413111 PMID:28238930 |
|
NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816
|
|
G
|
Mad1l1
|
mitotic arrest deficient 1 like 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 protein]
|
CTD |
PMID:35643323 |
|
NCBI chr12:19,434,782...19,744,574
Ensembl chr12:19,434,746...19,744,567
|
|
G
|
Mad2l1
|
mitotic arrest deficient 2 like 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 protein]
|
CTD |
PMID:35643323 |
|
NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:97,236,503...97,243,222
|
|
G
|
Maoa
|
monoamine oxidase A
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein]
|
CTD |
PMID:37348669 |
|
NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631
|
|
G
|
Map1lc3a
|
microtubule-associated protein 1 light chain 3 alpha
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]
|
CTD |
PMID:35568058 |
|
NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850
|
|
G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Atrazine results in increased expression of MAP1LC3B protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]; Melatonin inhibits the reaction [Radon results in increased expression of MAP1LC3B protein]; Melatonin promotes the reaction [Paraquat results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Melatonin results in increased expression of and results in increased lipidation of MAP1LC3B protein; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]]
|
CTD |
PMID:25259610 PMID:33107683 PMID:36421005 PMID:37028639 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358 Ensembl chr16:66,574,407...66,584,358
|
|
G
|
Map2
|
microtubule-associated protein 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459
|
|
G
|
Map2k1
|
mitogen activated protein kinase kinase 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184
|
|
G
|
Map2k6
|
mitogen-activated protein kinase kinase 6
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK1 protein] Melatonin inhibits the reaction [arsenite results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein] 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]
|
CTD |
PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 PMID:36343453 More...
|
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK3 protein] Melatonin inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein] 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]
|
CTD |
PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 PMID:36343453 More...
|
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [arsenite results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:36343453 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Mapt
|
microtubule-associated protein tau
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein] Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]; Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]] Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]
|
CTD |
PMID:10617124 PMID:15842767 PMID:23963992 PMID:31833155 PMID:35526705 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
|
|
G
|
Mbp
|
myelin basic protein
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]
|
CTD |
PMID:29476728 |
|
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
|
|
G
|
Mcl1
|
MCL1 apoptosis regulator, BCL2 family member
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [oxaliplatin results in decreased expression of MCL1 protein] Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of MCL1 protein]
|
CTD |
PMID:20626587 PMID:38229313 |
|
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
|
|
G
|
Mcm5
|
minichromosome maintenance complex component 5
|
multiple interactions
|
ISO
|
Melatonin affects the reaction [Manganese affects the expression of MCM5 mRNA]; Melatonin affects the reaction [Manganese affects the expression of MCM5 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of MCM5 mRNA]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of MCM5 protein]]
|
CTD |
PMID:38563506 |
|
NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758
|
|
G
|
Me1
|
malic enzyme 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]
|
CTD |
PMID:20033131 |
|
NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275
|
|
G
|
Mff
|
mitochondrial fission factor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MFF mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of MFF protein]
|
CTD |
PMID:33962019 PMID:36549428 |
|
NCBI chr 9:91,455,931...91,484,171
Ensembl chr 9:91,455,871...91,484,171
|
|
G
|
Mfn1
|
mitofusin 1
|
multiple interactions increases expression
|
EXP ISO
|
[Doxorubicin results in increased susceptibility to Melatonin] which results in increased expression of MFN1 protein; [Melatonin results in increased susceptibility to Doxorubicin] which results in increased expression of MFN1 protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of MFN1 protein] Melatonin results in increased expression of MFN1 mRNA
|
CTD |
PMID:29966675 PMID:33962019 PMID:36549428 |
|
NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190
|
|
G
|
Mfn2
|
mitofusin 2
|
multiple interactions increases expression
|
EXP ISO
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein] Melatonin affects the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of MFN2 mRNA] Melatonin results in increased expression of MFN2 mRNA
|
CTD |
PMID:26882442 PMID:29966675 PMID:33962019 |
|
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
|
|
G
|
Mief2
|
mitochondrial elongation factor 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MIEF2 mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr10:45,408,055...45,414,144
Ensembl chr10:45,908,706...45,913,658
|
|
G
|
Mir200a
|
microRNA 200a
|
decreases expression
|
EXP
|
melatonin decreases expression of Mir200a RNA in pulmonary artery smooth muscle cells
|
RGD |
PMID:30240970 |
RGD:156430315 |
NCBI chr 5:171,930,717...171,930,805
|
|
G
|
Mir21
|
microRNA 21
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cisplatin results in increased expression of MIR21 mRNA]
|
CTD |
PMID:36006825 |
|
NCBI chr10:71,902,600...71,902,691
|
|
G
|
Mir34a
|
microRNA 34a
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MIR34A mRNA]
|
CTD |
PMID:38229313 |
|
NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053
|
|
G
|
Mir497
|
microRNA 497
|
multiple interactions increases expression
|
ISO
|
MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA] Melatonin results in increased expression of MIR497 mRNA
|
CTD |
PMID:28095641 |
|
NCBI chr10:55,450,171...55,450,239
Ensembl chr10:55,450,162...55,450,241
|
|
G
|
Mir532
|
microRNA 532
|
increases expression multiple interactions
|
ISO
|
Melatonin results in increased expression of MIR532 [Melatonin results in increased expression of MIR532] which results in increased susceptibility to Fluorouracil; MIR532 promotes the reaction [Melatonin results in decreased expression of BCL2 protein]; MIR532 promotes the reaction [Melatonin results in decreased expression of CTNNB1 protein]; MIR532 promotes the reaction [Melatonin results in decreased expression of CTNND1 protein]; MIR532 promotes the reaction [Melatonin results in decreased expression of GSK3B protein]; MIR532 promotes the reaction [Melatonin results in decreased expression of MYC protein]; MIR532 promotes the reaction [Melatonin results in increased expression of BAX protein]
|
CTD |
PMID:37755321 |
|
NCBI chr X:17,919,185...17,919,263
Ensembl chr X:17,919,185...17,919,263
|
|
G
|
Mir675
|
microRNA 675
|
increases expression
|
EXP
|
melatonin increases expression of Mir675 RNA in pulmonary artery smooth muscle cells
|
RGD |
PMID:30240970 |
RGD:156430315 |
NCBI chr 1:197,732,275...197,732,358
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
multiple interactions decreases expression
|
EXP ISO
|
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MKI67 protein]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of MKI67 protein] Melatonin results in decreased expression of MKI67 mRNA; Melatonin results in decreased expression of MKI67 protein
|
CTD |
PMID:19028472 PMID:21062352 PMID:36154502 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
|
|
G
|
Mlkl
|
mixed lineage kinase domain like pseudokinase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased expression of MLKL protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein]
|
CTD |
PMID:35844137 PMID:36549428 |
|
NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
|
|
G
|
Mme
|
membrane metallo-endopeptidase
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of MME protein]
|
CTD |
PMID:33130240 |
|
NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463
|
|
G
|
Mmp14
|
matrix metallopeptidase 14
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
|
CTD |
PMID:16934674 |
|
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions decreases expression
|
EXP ISO
|
Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein] Melatonin results in decreased expression of MMP2 mRNA; Melatonin results in decreased expression of MMP2 protein [Doxorubicin co-treated with Melatonin] results in decreased expression of MMP2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP2 mRNA] Melatonin inhibits the reaction [sodium arsenite results in increased expression of MMP2 protein]
|
CTD |
PMID:16150113 PMID:16934674 PMID:29763682 PMID:33507000 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions decreases expression
|
EXP ISO
|
Melatonin inhibits the reaction [Galactose results in decreased expression of MMP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of and results in increased secretion of MMP9 protein]; Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; SIRT3 protein affects the reaction [Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]] Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 mRNA]; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 protein] Melatonin results in decreased expression of MMP9 mRNA; Melatonin results in decreased expression of MMP9 protein
|
CTD |
PMID:16150113 PMID:33507000 PMID:34673010 PMID:37350538 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
ISO
|
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; Melatonin inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
|
CTD |
PMID:26519479 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Mt-co1
|
mitochondrially encoded cytochrome c oxidase I
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of COX1 protein]
|
CTD |
PMID:36549428 |
|
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853
|
|
G
|
Mt-co2
|
mitochondrially encoded cytochrome c oxidase II
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Paraquat results in increased expression of COX2 protein]
|
CTD |
PMID:37028639 |
|
NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674
|
|
G
|
Mt1a
|
metallothionein 1A
|
multiple interactions
|
EXP
|
Melatonin promotes the reaction [lead acetate results in increased expression of MT1A mRNA]
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CTD |
PMID:25601058 |
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NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200 Ensembl chr X:79,695,809...79,696,200 Ensembl chr19:79,695,809...79,696,200
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G
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Mt2
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metallothionein 2
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multiple interactions
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EXP
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Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA]
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CTD |
PMID:25601058 |
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NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
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G
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Mtnr1a
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melatonin receptor 1A
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affects binding multiple interactions increases expression
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ISO EXP
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Melatonin analog binds to MTNR1A protein; Melatonin binds to MTNR1A protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of MTNR1A protein] Melatonin results in increased expression of MTNR1A protein Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein] [Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein; luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]
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CTD |
PMID:11063602 PMID:17645693 PMID:20399199 PMID:23591044 PMID:28027439 PMID:28238930 PMID:29330934 PMID:38440074 PMID:38538260 More...
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NCBI chr16:47,144,461...47,163,919
Ensembl chr16:53,876,964...53,896,421
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G
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Mtnr1b
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melatonin receptor 1B
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multiple interactions increases expression affects binding
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ISO EXP
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[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein] Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] Melatonin analog binds to MTNR1B protein; Melatonin binds to MTNR1B protein
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CTD |
PMID:11063602 PMID:11270484 PMID:16030176 PMID:17645693 PMID:20399199 PMID:26283214 PMID:28027439 PMID:28238930 More...
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NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:20,919,593...20,934,109
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G
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Mtor
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mechanistic target of rapamycin kinase
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multiple interactions increases phosphorylation increases activity
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ISO EXP
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Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] Melatonin inhibits the reaction [Methotrexate results in increased phosphorylation of MTOR protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]] Melatonin results in increased activity of MTOR protein
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CTD |
PMID:19054297 PMID:24799992 PMID:35568058 PMID:36421005 PMID:36890697 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
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G
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Myc
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MYC proto-oncogene, bHLH transcription factor
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multiple interactions decreases expression
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ISO
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MIR532 promotes the reaction [Melatonin results in decreased expression of MYC protein]
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CTD |
PMID:37755321 |
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NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
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G
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Myd88
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MYD88, innate immune signal transduction adaptor
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multiple interactions
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EXP
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Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]
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CTD |
PMID:28238930 PMID:36566971 |
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NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
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G
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Ncam1
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neural cell adhesion molecule 1
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increases expression
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EXP
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melatonin increases expression of NCAM1 protein isoform 180 in hippocampus of ethanol treated rats
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RGD |
PMID:16207289 |
RGD:401959613 |
NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971
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G
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Ncoa1
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nuclear receptor coactivator 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA1 protein]
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CTD |
PMID:29330934 |
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NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924
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G
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Ncoa3
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nuclear receptor coactivator 3
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein]
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CTD |
PMID:29330934 |
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NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631
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G
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Ndufb8
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NADH:ubiquinone oxidoreductase subunit B8
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in decreased expression of NDUFB8 protein]
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CTD |
PMID:36549428 |
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NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936
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G
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Nedd4
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NEDD4 E3 ubiquitin protein ligase
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affects response to substance multiple interactions decreases expression
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ISO
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[NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to Melatonin Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein] Melatonin results in decreased expression of NEDD4 protein
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CTD |
PMID:31325559 |
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NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633
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G
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Nefh
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neurofilament heavy chain
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decreases phosphorylation
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ISO
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Melatonin analog results in decreased phosphorylation of NEFH protein; Melatonin results in decreased phosphorylation of NEFH protein
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CTD |
PMID:18231852 |
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NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417
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G
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Nes
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nestin
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decreases expression multiple interactions
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ISO EXP
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Melatonin results in decreased expression of NES protein Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]
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CTD |
PMID:16369854 PMID:17572393 PMID:21269327 |
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NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228
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G
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Nfe2l2
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NFE2 like bZIP transcription factor 2
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multiple interactions increases expression
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EXP ISO
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Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein] Melatonin results in increased expression of NFE2L2 mRNA 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Melatonin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; Melatonin inhibits the reaction [arsenite results in increased expression of NFE2L2 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA] 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NFE2L2 mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]] Melatonin results in increased expression of NFE2L2 protein
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CTD |
PMID:20433640 PMID:25288107 PMID:25550330 PMID:27871981 PMID:30372842 PMID:31330490 PMID:33962019 PMID:34146326 PMID:35598369 PMID:36343453 PMID:36549428 PMID:37598416 PMID:37994397 PMID:38229313 More...
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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G
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Nfkb1
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nuclear factor kappa B subunit 1
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NFKB1 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NFKB1 mRNA] Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]
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CTD |
PMID:19028472 PMID:21158907 PMID:23963992 PMID:30372842 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
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G
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Nfkbia
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NFKB inhibitor alpha
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multiple interactions
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ISO EXP
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luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]; Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein] Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of and results in increased localization of NFKBIA protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]
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CTD |
PMID:26283214 PMID:35526705 PMID:36566971 |
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NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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G
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Nhej1
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nonhomologous end-joining factor 1
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multiple interactions
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ISO
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Melatonin promotes the reaction [bisphenol A results in increased expression of NHEJ1 mRNA]
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CTD |
PMID:36633214 |
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NCBI chr 9:83,974,995...84,071,161
Ensembl chr 9:83,974,997...84,070,594
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G
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Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions decreases expression
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ISO
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[Nickel co-treated with Melatonin] results in decreased expression of NLRP3 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Nickel inhibits the reaction [Melatonin results in decreased expression of NLRP3 mRNA] Melatonin inhibits the reaction [arsenite results in increased expression of NLRP3 protein]
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CTD |
PMID:36343453 PMID:36504304 |
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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G
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Nos1
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nitric oxide synthase 1
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multiple interactions decreases expression
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EXP
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Melatonin affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA] Melatonin results in decreased expression of NOS1 mRNA
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CTD |
PMID:16948784 PMID:21442002 PMID:21986892 |
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NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
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G
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Nos2
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nitric oxide synthase 2
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multiple interactions increases expression decreases expression
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ISO EXP
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Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein] Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA] Melatonin results in increased expression of NOS2 mRNA Melatonin results in decreased expression of NOS2 mRNA Melatonin affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA]; Melatonin affects the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Amphetamine results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of NOS2 protein]
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CTD |
PMID:12074098 PMID:16801527 PMID:16948784 PMID:18524487 PMID:21442002 PMID:21986892 PMID:22526374 PMID:23963992 PMID:29763682 PMID:30372842 PMID:31330490 PMID:33146023 More...
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
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Nos3
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nitric oxide synthase 3
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multiple interactions
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ISO
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Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]]
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CTD |
PMID:21585521 |
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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G
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Notch2
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notch receptor 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form]
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CTD |
PMID:37277016 |
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NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823
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G
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Nox1
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NADPH oxidase 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX1 mRNA]
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CTD |
PMID:36633214 |
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NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520
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G
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Nox4
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NADPH oxidase 4
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Galactose results in increased expression of NOX4 protein] Melatonin inhibits the reaction [bisphenol A results in increased expression of NOX4 mRNA]
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CTD |
PMID:34673010 PMID:36633214 |
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NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
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G
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Npm1
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nucleophosmin 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]
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CTD |
PMID:31325559 |
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NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024 Ensembl chr X:18,245,740...18,256,024
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G
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Nppb
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natriuretic peptide B
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]
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CTD |
PMID:17198541 PMID:35093381 |
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NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
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G
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Nqo1
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NAD(P)H quinone dehydrogenase 1
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multiple interactions increases expression
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EXP ISO
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[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Melatonin inhibits the reaction [bisphenol A results in decreased expression of NQO1 protein]]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA] Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NQO1 mRNA]] Melatonin results in increased expression of NQO1 protein
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CTD |
PMID:20033131 PMID:20433640 PMID:24969583 PMID:25288107 PMID:27871981 PMID:31330490 PMID:34146326 PMID:36549428 PMID:37598416 More...
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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G
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Nqo2
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N-ribosyldihydronicotinamide:quinone dehydrogenase 2
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multiple interactions affects activity
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ISO
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Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] Melatonin affects the activity of NQO2 protein
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CTD |
PMID:20399199 PMID:22289031 |
|
NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662
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G
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Nr1h3
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nuclear receptor subfamily 1, group H, member 3
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein]
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CTD |
PMID:21689150 |
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NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
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G
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Nr1i2
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nuclear receptor subfamily 1, group I, member 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA]
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CTD |
PMID:15617534 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
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G
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Nr3c1
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nuclear receptor subfamily 3, group C, member 1
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multiple interactions affects localization
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ISO EXP
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Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Melatonin promotes the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]] Melatonin inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA] Melatonin affects the localization of NR3C1 protein
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CTD |
PMID:10463946 PMID:15813899 PMID:18395440 |
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NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
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G
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Nr4a2
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nuclear receptor subfamily 4, group A, member 2
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multiple interactions
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ISO
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Melatonin affects the reaction [Manganese results in decreased expression of NR4A2 protein]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CCNA1 protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CCND1 protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDK2 protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDKN1B protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of CDKN1C protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of E2F1 protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of MCM5 mRNA]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of MCM5 protein]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of PCNA mRNA]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of PCNA protein]]
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CTD |
PMID:38563506 |
|
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769
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G
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Nrf1
|
nuclear respiratory factor 1
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multiple interactions
|
EXP
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Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NRF1 protein]
|
CTD |
PMID:26882442 |
|
NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353
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G
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Nthl1
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nth-like DNA glycosylase 1
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of NTHL1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr10:14,160,334...14,166,502
Ensembl chr10:14,160,330...14,166,966
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G
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Ntrk2
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neurotrophic receptor tyrosine kinase 2
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]
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CTD |
PMID:23963992 PMID:29476728 |
|
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
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|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN protein]
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CTD |
PMID:37598416 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
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G
|
Ogg1
|
8-oxoguanine DNA glycosylase
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of OGG1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604
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|
G
|
Opa1
|
OPA1, mitochondrial dynamin like GTPase
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of OPA1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of OPA1 protein] Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]
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CTD |
PMID:33962019 PMID:35093381 PMID:36549428 |
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NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955
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|
G
|
P2ry4
|
pyrimidinergic receptor P2Y4
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr X:65,681,680...65,717,404
Ensembl chr X:69,721,753...69,753,510
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G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form]; Melatonin inhibits the reaction [Tenofovir results in increased expression of PARP1 protein] Melatonin inhibits the reaction [bisphenol A results in decreased expression of PARP1 mRNA] Melatonin inhibits the reaction [Atrazine results in increased cleavage of PARP1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of PARP1 mRNA]
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CTD |
PMID:25259610 PMID:29966675 PMID:33146023 PMID:36633214 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
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|
G
|
Pawr
|
pro-apoptotic WT1 regulator
|
decreases expression
|
EXP
|
Melatonin results in decreased expression of PAWR protein
|
CTD |
PMID:15964511 |
|
NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492
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G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions decreases expression
|
EXP ISO
|
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein] Melatonin inhibits the reaction [bisphenol A results in decreased expression of PCNA mRNA] Melatonin affects the reaction [Manganese affects the expression of PCNA mRNA]; Melatonin affects the reaction [Manganese affects the expression of PCNA protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of PCNA protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of PCNA mRNA]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of PCNA mRNA]]; NR4A2 protein affects the reaction [Melatonin affects the reaction [Manganese affects the expression of PCNA protein]] Melatonin results in decreased expression of PCNA mRNA
|
CTD |
PMID:19028472 PMID:21062352 PMID:35643323 PMID:36633214 PMID:38563506 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
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|
G
|
Pdcd4
|
programmed cell death 4
|
increases expression
|
EXP
|
melatonin increases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells
|
RGD |
PMID:30240970 |
RGD:156430315 |
NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
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|
G
|
Pde1b
|
phosphodiesterase 1B
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:136,505,689...136,533,033
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G
|
Pdgfra
|
platelet derived growth factor receptor alpha
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516
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|
G
|
Pecr
|
peroxisomal trans-2-enoyl-CoA reductase
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PECR mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 9:81,347,170...81,375,809
Ensembl chr 9:81,347,173...81,375,806
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|
G
|
Per1
|
period circadian regulator 1
|
multiple interactions
|
EXP
|
Melatonin affects the reaction [Cadmium Chloride affects the expression of PER1]; Melatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA]
|
CTD |
PMID:17590544 PMID:21442002 PMID:23085516 PMID:25430725 |
|
NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211
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|
G
|
Per2
|
period circadian regulator 2
|
multiple interactions affects expression
|
EXP
|
Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA] Melatonin affects the expression of PER2 mRNA
|
CTD |
PMID:17590544 PMID:21442002 PMID:25430725 |
|
NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993
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|
G
|
Pf4
|
platelet factor 4
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA
|
CTD |
PMID:21461237 |
|
NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392
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G
|
Pgr
|
progesterone receptor
|
multiple interactions decreases expression
|
ISO EXP
|
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR] Melatonin results in decreased expression of PGR protein alternative form [Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form; [Ethanol co-treated with Melatonin] results in increased expression of PGR protein alternative form; Ethanol inhibits the reaction [Melatonin results in decreased expression of PGR protein alternative form]; Melatonin inhibits the reaction [Ethanol results in decreased expression of PGR protein alternative form]
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CTD |
PMID:22041583 PMID:23591044 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
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|
G
|
Pik3r1
|
phosphoinositide-3-kinase regulatory subunit 1
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PIK3R1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PIK3R1 protein]
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CTD |
PMID:35568058 PMID:37975621 |
|
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347
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|
G
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Pink1
|
PTEN induced kinase 1
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multiple interactions increases expression
|
EXP ISO
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] Melatonin results in increased expression of PINK1 protein [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein] [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PINK1 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]
|
CTD |
PMID:26882442 PMID:29966675 PMID:33962019 PMID:37028639 |
|
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
|
|
G
|
Pmaip1
|
phorbol-12-myristate-13-acetate-induced protein 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PMAIP1 mRNA]
|
CTD |
PMID:33962019 |
|
NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382
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|
G
|
Polb
|
DNA polymerase beta
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of POLB mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr16:76,081,903...76,105,174
Ensembl chr16:76,081,864...76,108,180
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|
G
|
Pold3
|
DNA polymerase delta 3, accessory subunit
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of POLD3 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 1:163,830,217...163,870,015
Ensembl chr 1:163,830,437...163,869,202
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|
G
|
Pomc
|
proopiomelanocortin
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multiple interactions decreases response to substance
|
EXP ISO
|
[Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]; Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone] Melatonin results in decreased susceptibility to POMC protein
|
CTD |
PMID:11478929 PMID:19301769 PMID:21332028 |
|
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
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|
G
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Pou5f1
|
POU class 5 homeobox 1
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multiple interactions decreases expression
|
ISO
|
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein] Melatonin results in decreased expression of POU5F1 mRNA; Melatonin results in decreased expression of POU5F1 protein
|
CTD |
PMID:27551335 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
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|
G
|
Ppara
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peroxisome proliferator activated receptor alpha
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA protein] Melatonin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of PPARA protein]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]
|
CTD |
PMID:35367536 PMID:36006825 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
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|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
decreases expression increases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of PPARG mRNA Melatonin results in increased expression of PPARG mRNA; Melatonin results in increased expression of PPARG protein GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PPARG protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PPARG protein]
|
CTD |
PMID:20738756 PMID:29734669 PMID:33962019 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions increases expression
|
ISO EXP
|
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Melatonin inhibits the reaction [bisphenol A results in decreased expression of PPARGC1A protein]]; [bisphenol A co-treated with Melatonin] results in increased expression of PPARGC1A protein; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]] Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA] Melatonin results in increased expression of PPARGC1A mRNA; Melatonin results in increased expression of PPARGC1A protein Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]
|
CTD |
PMID:25159133 PMID:26882442 PMID:29966675 PMID:33962019 PMID:35367536 PMID:36549428 More...
|
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
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|
G
|
Prkn
|
parkin RBR E3 ubiquitin protein ligase
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein]
|
CTD |
PMID:26882442 |
|
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
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|
G
|
Prl
|
prolactin
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL]
|
CTD |
PMID:23085516 |
|
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
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|
G
|
Prmt1
|
protein arginine methyltransferase 1
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Methotrexate results in decreased expression of PRMT1 protein]
|
CTD |
PMID:36890697 |
|
NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827
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|
G
|
Prnp
|
prion protein
|
increases expression multiple interactions
|
ISO
|
Melatonin results in increased expression of PRNP protein GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PRNP protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PRNP protein]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
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CTD |
PMID:29734669 |
|
NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436
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|
G
|
Prom1
|
prominin 1
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decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of PROM1 mRNA; Melatonin results in decreased expression of PROM1 protein 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; N-caproylsphingosine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; N-caproylsphingosine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]
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CTD |
PMID:30421542 |
|
NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002
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|
G
|
Psen1
|
presenilin 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189
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|
G
|
Psmc4
|
proteasome 26S subunit, ATPase 4
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:92,476,690...92,485,060
|
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G
|
Psmd3
|
proteasome 26S subunit, non-ATPase 3
|
multiple interactions
|
ISO
|
[Oxygen deficiency co-treated with Melatonin] results in decreased expression of PSMD3 protein
|
CTD |
PMID:31325559 |
|
NCBI chr10:83,643,473...83,655,620
Ensembl chr10:84,139,677...84,151,878
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|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA] Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [Radon results in decreased expression of PTGS2 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]
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CTD |
PMID:18588940 PMID:23376440 PMID:33107683 PMID:36421005 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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|
G
|
Pycard
|
PYD and CARD domain containing
|
multiple interactions decreases expression
|
ISO
|
Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin inhibits the reaction [Nickel results in increased expression of PYCARD mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of PYCARD protein] Melatonin inhibits the reaction [arsenite results in increased expression of PYCARD protein] Melatonin results in decreased expression of PYCARD mRNA; Melatonin results in decreased expression of PYCARD protein
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CTD |
PMID:36343453 PMID:36504304 |
|
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
|
|
G
|
Rab7a
|
RAB7A, member RAS oncogene family
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of RAB7A protein]
|
CTD |
PMID:26882442 |
|
NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185
|
|
G
|
Raf1
|
Raf-1 proto-oncogene, serine/threonine kinase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
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|
G
|
Rara
|
retinoic acid receptor, alpha
|
multiple interactions
|
ISO
|
[Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein]
|
CTD |
PMID:10965999 PMID:15813899 |
|
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160
|
|
G
|
Rela
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RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO EXP
|
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RELA protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA protein]; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [[Formaldehyde co-treated with diisononyl phthalate] promotes the reaction [OVAL protein results in increased phosphorylation of RELA protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]; Melatonin inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]; Melatonin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein] Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]
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CTD |
PMID:20433640 PMID:22225513 PMID:22526374 PMID:26283214 PMID:27871981 PMID:27899301 PMID:29758289 PMID:34808223 PMID:34973135 PMID:36343453 PMID:36566971 PMID:37028639 PMID:37598416 More...
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
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Renbp
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renin binding protein
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multiple interactions
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ISO
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Melatonin inhibits the reaction [sodium arsenite results in increased expression of RENBP protein]
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CTD |
PMID:29763682 |
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NCBI chr X:156,812,785...156,821,860
Ensembl chr X:156,812,411...156,821,838
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G
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Rgn
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regucalcin
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]
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CTD |
PMID:29734669 |
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NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251
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G
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Ripk1
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receptor interacting serine/threonine kinase 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in increased expression of RIPK1 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK1 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein]
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CTD |
PMID:29763682 PMID:35844137 PMID:36549428 |
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NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167
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G
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Ripk3
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receptor-interacting serine-threonine kinase 3
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multiple interactions
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ISO EXP
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Melatonin inhibits the reaction [bisphenol A results in increased expression of RIPK3 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK3 protein] [Melatonin co-treated with Thioacetamide] results in increased expression of RIPK3 protein
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CTD |
PMID:29763682 PMID:31967703 PMID:35844137 PMID:36549428 |
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NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
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G
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Rora
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RAR-related orphan receptor A
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affects binding
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ISO
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Melatonin binds to RORA protein
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CTD |
PMID:16030176 |
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NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730
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G
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Rpl19
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ribosomal protein L19
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA]
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CTD |
PMID:23963992 |
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NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352
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G
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Rpl23
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ribosomal protein L23
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multiple interactions
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ISO
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Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]
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CTD |
PMID:31325559 |
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NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214
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G
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Rpl3
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ribosomal protein L3
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of RPL3 protein]
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CTD |
PMID:31325559 |
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NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:113,501,960...113,507,990
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G
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Rps19
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ribosomal protein S19
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multiple interactions
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ISO
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Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]
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CTD |
PMID:31325559 |
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NCBI chr 1:89,608,408...89,614,390
Ensembl chr 7:104,324,520...104,325,132 Ensembl chr 1:104,324,520...104,325,132
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G
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Rps7
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ribosomal protein S7
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multiple interactions
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ISO
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Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]
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CTD |
PMID:31325559 |
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NCBI chr 6:50,994,581...50,999,447
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G
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Runx2
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RUNX family transcription factor 2
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increases expression multiple interactions
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ISO EXP
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Melatonin results in increased expression of RUNX2 mRNA Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 protein] Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of RUNX2 mRNA]
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CTD |
PMID:20738756 PMID:31809235 PMID:38000455 |
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NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
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G
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S100g
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S100 calcium binding protein G
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increases expression multiple interactions
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EXP
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Melatonin results in increased expression of S100G mRNA; Melatonin results in increased expression of S100G protein Hydrogen Peroxide promotes the reaction [Melatonin results in increased expression of S100G protein]
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CTD |
PMID:20041988 |
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NCBI chr X:35,337,636...35,340,205
Ensembl chr X:35,337,675...35,340,205
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G
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Sdhb
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succinate dehydrogenase complex iron sulfur subunit B
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in decreased expression of SDHB protein]
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CTD |
PMID:36549428 |
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NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667
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G
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Sds
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serine dehydratase
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multiple interactions
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ISO
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[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of SDS mRNA
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CTD |
PMID:38325522 |
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NCBI chr12:41,743,796...41,751,108
Ensembl chr12:41,743,799...41,748,773
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G
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Selenom
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selenoprotein M
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multiple interactions affects response to substance
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ISO
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[SELENOM protein affects the susceptibility to Melatonin] which affects the abundance of Malondialdehyde; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Melatonin inhibits the reaction [SELENOM protein affects the susceptibility to Nickel]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]]
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CTD |
PMID:36504304 |
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NCBI chr14:78,395,826...78,398,429
Ensembl chr14:82,619,436...82,622,054
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G
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Serpinb3
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serpin family B member 3
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multiple interactions
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ISO
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[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of SERPINB3 mRNA
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CTD |
PMID:38325522 |
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NCBI chr13:23,788,758...23,795,298
Ensembl chr13:23,788,758...23,795,298
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G
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Setdb1
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SET domain bifurcated histone lysine methyltransferase 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of SETDB1 protein]
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CTD |
PMID:35643323 |
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NCBI chr 2:185,587,722...185,619,084
Ensembl chr 2:185,587,722...185,618,982
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G
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Sirt1
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sirtuin 1
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decreases expression multiple interactions
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ISO EXP
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Melatonin results in decreased expression of SIRT1 protein Melatonin inhibits the reaction [bisphenol A results in decreased expression of SIRT1 protein] Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SIRT1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of and results in decreased localization of SIRT1 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Melatonin inhibits the reaction [bisphenol A results in decreased expression of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]
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CTD |
PMID:21062352 PMID:25159133 PMID:29966675 PMID:35598369 PMID:36549428 PMID:36566971 PMID:38229313 More...
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NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
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G
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Sirt3
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sirtuin 3
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 mRNA]; Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 protein]; SIRT3 protein affects the reaction [Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]] Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of SIRT3 protein]; Melatonin inhibits the reaction [Particulate Matter results in decreased expression of SIRT3 protein]; SIRT3 protein promotes the reaction [Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in increased acetylation of TP53 protein]]
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CTD |
PMID:37350538 PMID:37994397 |
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NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076
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G
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Slc16a2
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solute carrier family 16 member 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Glyphosate affects the expression of SLC16A2 mRNA]
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CTD |
PMID:33159990 |
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NCBI chr X:72,791,096...72,914,299
Ensembl chr X:72,781,876...72,914,498
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G
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Slc18a2
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solute carrier family 18 member A2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]
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CTD |
PMID:20964710 |
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NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231
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G
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Slc22a2
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solute carrier family 22 member 2
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA] Melatonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
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CTD |
PMID:21599003 PMID:23963992 |
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NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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G
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Slc2a4
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solute carrier family 2 member 4
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA] Melatonin inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]
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CTD |
PMID:17198541 PMID:29763682 |
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NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
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G
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Slc5a5
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solute carrier family 5 member 5
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Glyphosate results in decreased expression of NIS mRNA]
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CTD |
PMID:33159990 |
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NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691
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G
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Slc6a3
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solute carrier family 6 member 3
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein] Melatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]
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CTD |
PMID:18289173 PMID:24969583 |
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NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
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G
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Snca
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synuclein alpha
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multiple interactions
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EXP ISO
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Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]] Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]
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CTD |
PMID:17645694 PMID:18289173 PMID:34808223 |
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NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
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G
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Sod1
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superoxide dismutase 1
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multiple interactions increases activity increases expression
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EXP ISO
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[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA] Melatonin results in increased activity of SOD1 protein Melatonin results in increased expression of SOD1 mRNA [aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]; Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of SOD1 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 protein]
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CTD |
PMID:11523592 PMID:15589378 PMID:17198541 PMID:19405147 PMID:19680607 PMID:20210856 PMID:21442002 PMID:23554006 PMID:37277016 PMID:37975621 PMID:37994397 PMID:38440074 More...
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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G
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Sod2
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superoxide dismutase 2
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multiple interactions increases activity increases expression
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EXP ISO
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Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD2 protein] luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of SOD2 protein] Melatonin results in increased expression of SOD2 mRNA Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
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CTD |
PMID:10942521 PMID:11523592 PMID:15589378 PMID:16098089 PMID:20210856 PMID:21442002 PMID:23554006 PMID:25288107 PMID:26882442 PMID:38440074 More...
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
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G
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Spp1
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secreted phosphoprotein 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 protein]
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CTD |
PMID:38000455 |
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NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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G
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Sqstm1
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sequestosome 1
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multiple interactions increases expression
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EXP ISO
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Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein] Melatonin results in increased expression of SQSTM1 protein Melatonin inhibits the reaction [Atrazine results in increased expression of SQSTM1 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 protein]; Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]] Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]
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CTD |
PMID:25259610 PMID:26882442 PMID:31330490 PMID:33107683 PMID:36421005 PMID:37028639 More...
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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G
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Srebf1
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sterol regulatory element binding transcription factor 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein]
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CTD |
PMID:21689150 |
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NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
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G
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Star
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steroidogenic acute regulatory protein
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multiple interactions
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ISO
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Melatonin inhibits the reaction [bisphenol A results in decreased expression of STAR protein]
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CTD |
PMID:38440074 |
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NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
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G
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Stat1
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signal transducer and activator of transcription 1
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multiple interactions
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ISO
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Melatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
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CTD |
PMID:21158907 PMID:22225513 |
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NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
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G
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Stat3
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signal transducer and activator of transcription 3
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multiple interactions increases response to substance increases phosphorylation
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ISO EXP
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Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] STAT3 protein results in increased susceptibility to Melatonin Melatonin results in increased phosphorylation of STAT3 protein Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STAT3 protein]
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CTD |
PMID:19028472 PMID:21342247 PMID:22225513 PMID:23963992 PMID:27871981 |
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NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
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G
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Stat4
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signal transducer and activator of transcription 4
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multiple interactions
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ISO
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Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]
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CTD |
PMID:23963992 |
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NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346
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G
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Stat5a
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signal transducer and activator of transcription 5A
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multiple interactions
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ISO
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Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]
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CTD |
PMID:27871981 |
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NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
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G
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Stat6
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signal transducer and activator of transcription 6
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]
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CTD |
PMID:27871981 |
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NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
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G
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Stra8
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stimulated by retinoic acid 8
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multiple interactions
|
ISO
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Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of STRA8 protein]
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CTD |
PMID:37994397 |
|
NCBI chr 4:64,568,580...64,591,914
Ensembl chr 4:64,568,706...64,591,911
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G
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Syp
|
synaptophysin
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multiple interactions
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EXP
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Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]; Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein]
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CTD |
PMID:17572393 PMID:19409439 |
|
NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984
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G
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Syt5
|
synaptotagmin 5
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746
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G
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Tat
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tyrosine aminotransferase
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multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of TAT mRNA
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CTD |
PMID:38325522 |
|
NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
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G
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Tdo2
|
tryptophan 2,3-dioxygenase
|
multiple interactions
|
EXP
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[Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin
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CTD |
PMID:16952380 |
|
NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586
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G
|
Tf
|
transferrin
|
increases expression multiple interactions
|
EXP
|
Melatonin results in increased expression of TF protein [Melatonin results in increased expression of TF protein] which affects the abundance of Iron
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CTD |
PMID:18571630 |
|
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
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G
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Tfam
|
transcription factor A, mitochondrial
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multiple interactions increases expression
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ISO EXP
|
Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein] Melatonin results in increased expression of TFAM mRNA Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]
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CTD |
PMID:21797922 PMID:26882442 PMID:33962019 |
|
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
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G
|
Tff1
|
trefoil factor 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]
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CTD |
PMID:27551335 |
|
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956
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G
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Tfrc
|
transferrin receptor
|
decreases expression
|
EXP
|
Melatonin results in decreased expression of TFRC mRNA; Melatonin results in decreased expression of TFRC protein
|
CTD |
PMID:17091493 PMID:18571630 |
|
NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318
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|
G
|
Tg
|
thyroglobulin
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in decreased expression of TG mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539 Ensembl chr 7:100,307,349...100,314,539
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|
G
|
Tgfa
|
transforming growth factor alpha
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]
|
CTD |
PMID:36343453 |
|
NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
ISO EXP
|
[Tretinoin co-treated with Melatonin] results in increased expression of TGFB1 mRNA Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA] Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]
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CTD |
PMID:9649124 PMID:17572393 PMID:23963992 PMID:26882442 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
|
G
|
Th
|
tyrosine hydroxylase
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein] [Melatonin co-treated with ortho-topolin riboside] results in decreased expression of TH mRNA Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]
|
CTD |
PMID:18289173 PMID:19409439 PMID:20964710 PMID:24969583 PMID:34808223 PMID:38325522 More...
|
|
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
|
|
G
|
Timp2
|
TIMP metallopeptidase inhibitor 2
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
|
CTD |
PMID:16934674 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
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|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]
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CTD |
PMID:37598416 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of TLR4 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TLR4 protein]
|
CTD |
PMID:27413111 PMID:28238930 PMID:34808223 PMID:36566971 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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|
G
|
Tlr9
|
toll-like receptor 9
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Paraquat results in increased expression of TLR9 protein]
|
CTD |
PMID:37028639 |
|
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148
|
|
G
|
Tmem236
|
transmembrane protein 236
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in decreased expression of TMEM236 mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr17:77,180,919...77,241,258
Ensembl chr17:82,096,528...82,148,211
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|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions decreases secretion
|
ISO EXP
|
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of TNF protein]; Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Cadmium results in increased expression of TNF protein]; Melatonin inhibits the reaction [Cadmium results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]] melatonin inhibits the reaction [methamphetamine increases expression of TNFa mRNA in rat microglial cell lines] melatonin inhibits the reaction [liver reperfusion increases secretion of Tnf protein in plasma] Melatonin results in decreased secretion of TNF protein [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]; Melatonin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Melatonin inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]
|
CTD RGD |
PMID:15714805 PMID:16373423 PMID:17602819 PMID:19028472 PMID:19080501 PMID:20374443 PMID:23374533 PMID:23963992 PMID:26283214 PMID:26519479 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30595364 PMID:32554039 PMID:34808223 PMID:35526705 PMID:35844137 PMID:36265525 PMID:36421005 PMID:36566971 PMID:37028639 PMID:37598416 PMID:38944328 PMID:20374443 PMID:11592783 More...
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RGD:598147057, RGD:2325259 |
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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|
G
|
Tnfaip3
|
TNF alpha induced protein 3
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
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G
|
Tnfrsf1b
|
TNF receptor superfamily member 1B
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increases response to substance
|
ISO
|
TNFRSF1B protein results in increased susceptibility to Melatonin
|
CTD |
PMID:21342247 |
|
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411
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|
G
|
Tp53
|
tumor protein p53
|
increases expression multiple interactions
|
ISO EXP
|
Melatonin results in increased expression of TP53 protein Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of TP53 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Glucose results in increased expression of TP53 protein] Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in increased acetylation of TP53 protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of TRP53 protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of TRP53 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]; Melatonin inhibits the reaction [Particulate Matter results in increased acetylation of TP53 protein]; SIRT3 protein promotes the reaction [Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in increased acetylation of TP53 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]] Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
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CTD |
PMID:12071473 PMID:14993511 PMID:20041988 PMID:20964710 PMID:23963992 PMID:24799992 PMID:25454643 PMID:33962019 PMID:35643323 PMID:36421005 PMID:36633214 PMID:37994397 PMID:38000455 More...
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|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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|
G
|
Tpo
|
thyroid peroxidase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in decreased expression of TPO mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:52,426,010...52,495,793
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|
G
|
Tradd
|
TNFRSF1A-associated via death domain
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TRADD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TRADD protein]
|
CTD |
PMID:29763682 PMID:35844137 |
|
NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550
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|
G
|
Trappc6a
|
trafficking protein particle complex subunit 6A
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA]
|
CTD |
PMID:31330490 |
|
NCBI chr 1:88,286,533...88,293,493
Ensembl chr 1:88,286,362...88,293,493
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|
G
|
Trh
|
thyrotropin releasing hormone
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in increased expression of TRH protein]
|
CTD |
PMID:33159990 |
|
NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:126,299,236...126,301,762
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|
G
|
Trhr
|
thyrotropin releasing hormone receptor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in increased expression of TRHR mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:77,233,354...77,277,987
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|
G
|
Trpv1
|
transient receptor potential cation channel, subfamily V, member 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased expression of TRPV1 protein]
|
CTD |
PMID:34146326 |
|
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
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|
G
|
Tshb
|
thyroid stimulating hormone subunit beta
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]; Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA] Melatonin inhibits the reaction [Glyphosate results in decreased expression of TSHB protein]
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CTD |
PMID:16948784 PMID:23085516 PMID:33159990 |
|
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984
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|
G
|
Tshr
|
thyroid stimulating hormone receptor
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [Glyphosate results in decreased expression of TSHR mRNA]
|
CTD |
PMID:33159990 |
|
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:116,072,281...116,206,010
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|
G
|
Tslp
|
thymic stromal lymphopoietin
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]
|
CTD |
PMID:27871981 |
|
NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420
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|
G
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Tubb5
|
tubulin, beta 5 class I
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multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
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G
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Twist1
|
twist family bHLH transcription factor 1
|
multiple interactions
|
ISO
|
TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]
|
CTD |
PMID:30421542 |
|
NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965
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G
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Txn1
|
thioredoxin 1
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of TXN1 mRNA Nickel inhibits the reaction [Melatonin results in decreased expression of TXN1 mRNA]
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CTD |
PMID:36504304 |
|
NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
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G
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Txnip
|
thioredoxin interacting protein
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of TXNIP mRNA Melatonin inhibits the reaction [arsenite results in increased expression of TXNIP protein] Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of TXNIP mRNA]
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CTD |
PMID:36343453 PMID:36504304 |
|
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
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G
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Txnrd3
|
thioredoxin reductase 3
|
multiple interactions decreases response to substance
|
ISO
|
TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin results in decreased susceptibility to nickel chloride] TXNRD3 gene mutant form results in decreased susceptibility to Melatonin
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CTD |
PMID:36421005 |
|
NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:123,648,750...123,668,552
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G
|
Ubb
|
ubiquitin B
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,727,701...47,750,335
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G
|
Ugt1a6
|
UDP glucuronosyltransferase family 1 member A6
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]; Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA]
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CTD |
PMID:22846377 |
|
NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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|
G
|
Ung
|
uracil-DNA glycosylase
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of UNG mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257
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|
G
|
Upp2
|
uridine phosphorylase 2
|
multiple interactions
|
ISO
|
[Melatonin co-treated with ortho-topolin riboside] results in increased expression of UPP2 mRNA
|
CTD |
PMID:38325522 |
|
NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191
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|
G
|
Uqcrc2
|
ubiquinol cytochrome c reductase core protein 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of UQCRC2 protein]
|
CTD |
PMID:36549428 |
|
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:184,599,212...184,630,946
|
|
G
|
Vamp5
|
vesicle-associated membrane protein 5
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:105,982,009...105,993,247
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|
G
|
Vegfa
|
vascular endothelial growth factor A
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of VEGFA mRNA]
|
CTD |
PMID:32554039 PMID:33962019 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|
G
|
Vps45
|
vacuolar protein sorting 45 homolog
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA]
|
CTD |
PMID:23963992 |
|
NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:186,244,842...186,305,177
|
|
G
|
Wnt3
|
Wnt family member 3
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]]
|
CTD |
PMID:35526705 |
|
NCBI chr10:89,180,224...89,224,195
Ensembl chr10:89,216,801...89,224,195
|
|
G
|
Wnt3a
|
Wnt family member 3A
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of WNT3A protein]
|
CTD |
PMID:31809235 |
|
NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919
|
|
G
|
Xbp1
|
X-box binding protein 1
|
multiple interactions
|
EXP ISO
|
Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein] Melatonin inhibits the reaction [Atrazine affects the splicing of XBP1]; Melatonin inhibits the reaction [bisphenol A results in increased expression of XBP1 protein]
|
CTD |
PMID:17645694 PMID:25259610 PMID:28070110 PMID:38538260 |
|
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
|
|
G
|
Xrcc1
|
X-ray repair cross complementing 1
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in decreased expression of XRCC1 mRNA] Melatonin promotes the reaction [bisphenol A results in increased expression of XRCC1 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613
|
|
G
|
Xrcc4
|
X-ray repair cross complementing 4
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in increased expression of XRCC4 mRNA] Melatonin inhibits the reaction [bisphenol A results in decreased expression of XRCC4 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160
|
|
G
|
Xrcc6
|
X-ray repair cross complementing 6
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [bisphenol A results in increased expression of XRCC6 mRNA]
|
CTD |
PMID:36633214 |
|
NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:115,422,662...115,443,884
|
|
G
|
Yap1
|
Yes1 associated transcriptional regulator
|
multiple interactions
|
EXP
|
Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of and results in increased phosphorylation of YAP1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]
|
CTD |
PMID:35093381 PMID:36154502 |
|
NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437
|
|
G
|
Ywhab
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
|
multiple interactions
|
ISO
|
Melatonin promotes the reaction [YWHAB protein binds to BAD protein]
|
CTD |
PMID:18078454 |
|
NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854
|
|
G
|
Yy1
|
YY1 transcription factor
|
decreases expression multiple interactions
|
ISO
|
Melatonin results in decreased expression of YY1 mRNA Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
|
CTD |
PMID:28095641 |
|
NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257
|
|
G
|
Zp2
|
zona pellucida glycoprotein 2
|
multiple interactions
|
ISO
|
Melatonin inhibits the reaction [bisphenol A results in increased cleavage of ZP2 protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in increased cleavage of ZP2 protein]
|
CTD |
PMID:28178360 PMID:31931096 |
|
NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:183,939,880...183,963,075
|
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
increases metabolic processing
|
ISO
|
CYP1A2 protein results in increased metabolism of N,N-Dimethyltryptamine
|
CTD |
PMID:27320963 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
|
G
|
Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
increases metabolic processing
|
ISO
|
CYP2C19 protein results in increased metabolism of N,N-Dimethyltryptamine
|
CTD |
PMID:27320963 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
|
|
G
|
Fmo3
|
flavin containing dimethylaniline monoxygenase 3
|
increases metabolic processing
|
ISO
|
FMO3 protein results in increased metabolism of N,N-Dimethyltryptamine
|
CTD |
PMID:27320963 |
|
NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
|
|
G
|
Htr2a
|
5-hydroxytryptamine receptor 2A
|
decreases response to substance multiple interactions affects response to substance
|
ISO
|
HTR2A gene SNP results in decreased susceptibility to N,N-Dimethyltryptamine N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A protein HTR2A protein affects the susceptibility to N,N-Dimethyltryptamine
|
CTD |
PMID:16314884 |
|
NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
|
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
N-acetyltryptophan inhibits the reaction [Aluminum Chloride results in decreased activity of ACHE protein]
|
CTD |
PMID:29185389 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Casp2
|
caspase 2
|
multiple interactions
|
ISO
|
N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP2 protein]
|
CTD |
PMID:37702290 |
|
NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP3 protein]
|
CTD |
PMID:37702290 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions
|
ISO
|
N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP9 protein]
|
CTD |
PMID:37702290 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
N-acetyltryptophan inhibits the reaction [Cobalt-60 results in decreased activity of CAT protein]
|
CTD |
PMID:37702290 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Xdh
|
xanthine dehydrogenase
|
multiple interactions
|
ISO
|
N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of XDH protein]
|
CTD |
PMID:37702290 |
|
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
|
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
|
CTD |
PMID:19961921 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ugt1a6
|
UDP glucuronosyltransferase family 1 member A6
|
multiple interactions increases glucuronidation
|
ISO
|
methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate inhibits the reaction [UGT1A6 protein results in increased glucuronidation of N-acetylserotonin]
|
CTD |
PMID:34910929 |
|
NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
|
G
|
Htr4
|
5-hydroxytryptamine receptor 4
|
increases response to substance increases activity multiple interactions
|
ISO
|
HTR4 protein results in increased susceptibility to psilocin psilocin results in increased activity of HTR4 protein [HTR4 protein results in increased susceptibility to psilocin] which results in increased phosphorylation of PLN protein
|
CTD |
PMID:38876450 |
|
NCBI chr18:55,765,981...55,949,921
Ensembl chr18:58,036,277...58,219,622
|
|
G
|
Pln
|
phospholamban
|
increases phosphorylation multiple interactions
|
ISO
|
psilocin results in increased phosphorylation of PLN protein [HTR4 protein results in increased susceptibility to psilocin] which results in increased phosphorylation of PLN protein
|
CTD |
PMID:38876450 |
|
NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241
|
|
|
G
|
Htr4
|
5-hydroxytryptamine receptor 4
|
multiple interactions increases activity increases response to substance
|
ISO
|
[HTR4 protein results in increased susceptibility to Psilocybin] which results in increased phosphorylation of PLN protein Psilocybin results in increased activity of HTR4 protein
|
CTD |
PMID:38876450 |
|
NCBI chr18:55,765,981...55,949,921
Ensembl chr18:58,036,277...58,219,622
|
|
G
|
Pln
|
phospholamban
|
multiple interactions
|
ISO
|
[HTR4 protein results in increased susceptibility to Psilocybin] which results in increased phosphorylation of PLN protein
|
CTD |
PMID:38876450 |
|
NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241
|
|
|
G
|
Actb
|
actin, beta
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [bisphenol A results in increased expression of ACTB protein]
|
CTD |
PMID:39527977 |
|
NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
|
|
G
|
Cfl1
|
cofilin 1
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [bisphenol A results in increased phosphorylation of CFL1 protein]
|
CTD |
PMID:39527977 |
|
NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:212,226,121...212,231,353
|
|
G
|
Limk1
|
LIM domain kinase 1
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [bisphenol A results in increased phosphorylation of LIMK1 protein]
|
CTD |
PMID:39527977 |
|
NCBI chr12:27,663,177...27,697,085
Ensembl chr12:27,663,018...27,697,209
|
|
G
|
Pfn1
|
profilin 1
|
multiple interactions
|
ISO
|
[rhosin co-treated with bisphenol A] results in decreased expression of PFN1 protein
|
CTD |
PMID:39527977 |
|
NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611
|
|
G
|
Rhoa
|
ras homolog family member A
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [bisphenol A results in increased expression of RHOA protein]
|
CTD |
PMID:39527977 |
|
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
|
|
G
|
Rock2
|
Rho-associated coiled-coil containing protein kinase 2
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [bisphenol A results in increased expression of ROCK2 protein]
|
CTD |
PMID:39527977 |
|
NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771
|
|
G
|
Xbp1
|
X-box binding protein 1
|
multiple interactions
|
ISO
|
rhosin inhibits the reaction [4-nitro-3-cresol results in increased expression of XBP1 mRNA]; rhosin inhibits the reaction [4-nitro-3-cresol results in increased expression of XBP1 protein]
|
CTD |
PMID:35910793 |
|
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
|
|
|
G
|
Acat1
|
acetyl-CoA acetyltransferase 1
|
multiple interactions increases expression
|
ISO
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; AG 1879 inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; Serotonin results in increased expression of and results in increased activity of ACAT1 protein Serotonin results in increased expression of ACAT1 mRNA alternative form
|
CTD |
PMID:16157345 |
|
NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
|
CTD |
PMID:26408985 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases activity multiple interactions
|
ISO
|
Serotonin results in increased activity of AKT1 protein [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]
|
CTD |
PMID:22975078 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
App
|
amyloid beta precursor protein
|
increases response to substance multiple interactions
|
ISO
|
APP protein modified form results in increased susceptibility to Serotonin Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] which results in increased susceptibility to Serotonin]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin]
|
CTD |
PMID:28915354 PMID:34902447 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Aqp3
|
aquaporin 3 (Gill blood group)
|
multiple interactions increases expression
|
ISO EXP
|
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA] Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
|
CTD |
PMID:25766885 |
|
NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
EXP ISO
|
[Butyrates co-treated with Serotonin] results in increased expression of BDNF mRNA; [trichostatin A co-treated with Serotonin] results in increased expression of BDNF mRNA; [Valproic Acid co-treated with Serotonin] results in increased expression of BDNF mRNA Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
|
CTD |
PMID:19360904 PMID:26408985 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
G
|
Calca
|
calcitonin-related polypeptide alpha
|
multiple interactions increases secretion
|
EXP
|
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]
|
CTD |
PMID:11166334 PMID:12791437 PMID:14991081 |
|
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]
|
CTD |
PMID:24650663 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp7
|
caspase 7
|
multiple interactions
|
ISO
|
Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein]
|
CTD |
PMID:24650663 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin]
|
CTD |
PMID:11435997 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl5
|
C-C motif chemokine ligand 5
|
increases expression
|
EXP
|
Serotonin results in increased expression of CCL5 protein
|
CTD |
PMID:38701902 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
|
|
G
|
Cftr
|
CF transmembrane conductance regulator
|
multiple interactions increases activity
|
ISO
|
Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein] Serotonin results in increased activity of CFTR protein
|
CTD |
PMID:15151902 |
|
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
|
|
G
|
Chat
|
choline O-acetyltransferase
|
multiple interactions
|
ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
|
CTD |
PMID:26408985 |
|
NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416
|
|
G
|
Cnr1
|
cannabinoid receptor 1
|
multiple interactions
|
ISO
|
Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of CNR1 protein]
|
CTD |
PMID:30611738 |
|
NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
|
|
G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]
|
CTD |
PMID:26408985 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
G
|
Crh
|
corticotropin releasing hormone
|
multiple interactions increases secretion
|
EXP
|
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]; corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin]
|
CTD |
PMID:14575894 |
|
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
|
|
G
|
Dbh
|
dopamine beta-hydroxylase
|
multiple interactions
|
ISO
|
DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]; DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin]
|
CTD |
PMID:15148402 |
|
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:30,886,328...30,903,316
|
|
G
|
Ddc
|
dopa decarboxylase
|
multiple interactions
|
EXP
|
[DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin
|
CTD |
PMID:32243540 |
|
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
|
|
G
|
Drd1
|
dopamine receptor D1
|
multiple interactions
|
EXP
|
Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]
|
CTD |
PMID:20887679 |
|
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
|
|
G
|
Drd2
|
dopamine receptor D2
|
multiple interactions
|
EXP
|
Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]
|
CTD |
PMID:20887679 |
|
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
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G
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En2
|
engrailed homeobox 2
|
affects abundance
|
ISO
|
EN2 protein affects the abundance of Serotonin; EN2 protein affects the abundance of Serotonin metabolite
|
CTD |
PMID:16935268 |
|
NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,954,953...7,960,793
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G
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Enam
|
enamelin
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decreases expression
|
ISO
|
Serotonin results in decreased expression of ENAM mRNA
|
CTD |
PMID:21083617 |
|
NCBI chr14:19,840,773...19,865,476
Ensembl chr14:19,840,773...19,865,468
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G
|
Faah
|
fatty acid amide hydrolase
|
multiple interactions
|
ISO
|
[Serotonin co-treated with Dextran Sulfate] results in decreased expression of FAAH protein
|
CTD |
PMID:30611738 |
|
NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396
|
|
G
|
Fgf1
|
fibroblast growth factor 1
|
increases expression
|
EXP
|
Serotonin results in increased expression of FGF1 protein
|
CTD |
PMID:15264218 |
|
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393
|
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G
|
Fgf5
|
fibroblast growth factor 5
|
affects uptake
|
EXP
|
FGF5 protein affects the uptake of Serotonin
|
CTD |
PMID:8167846 |
|
NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,627,906...11,650,243
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
increases expression
|
EXP
|
Serotonin results in increased expression of FOS mRNA
|
CTD |
PMID:10700011 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Gapdh
|
glyceraldehyde-3-phosphate dehydrogenase
|
multiple interactions
|
ISO
|
[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein
|
CTD |
PMID:23009681 |
|
NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
|
|
G
|
Ghrl
|
ghrelin and obestatin prepropeptide
|
decreases export
|
EXP
|
GHRL protein results in decreased export of Serotonin
|
CTD |
PMID:20553917 |
|
NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969
|
|
G
|
Gla
|
galactosidase, alpha
|
affects response to substance
|
ISO
|
GLA protein affects the susceptibility to Serotonin
|
CTD |
PMID:18565198 |
|
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:102,056,718...102,073,915
|
|
G
|
Gnai1
|
G protein subunit alpha i1
|
increases palmitoylation multiple interactions
|
EXP
|
Serotonin results in increased palmitoylation of GNAI1 protein Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAI1 protein]
|
CTD |
PMID:9732414 |
|
NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198
|
|
G
|
Gnao1
|
G protein subunit alpha o1
|
multiple interactions increases palmitoylation
|
EXP
|
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAO1 protein]
|
CTD |
PMID:9732414 |
|
NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437
|
|
G
|
Gnaq
|
G protein subunit alpha q
|
multiple interactions increases palmitoylation
|
EXP
|
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAQ protein]
|
CTD |
PMID:9732414 |
|
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:222,852,097...223,126,742
|
|
G
|
Gnas
|
GNAS complex locus
|
multiple interactions increases palmitoylation
|
EXP
|
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAS protein]
|
CTD |
PMID:9732414 |
|
NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536
|
|
G
|
Gpbar1
|
G protein-coupled bile acid receptor 1
|
multiple interactions
|
ISO
|
[Bile Acids and Salts binds to and results in increased activity of GPBAR1 protein] which results in increased secretion of Serotonin
|
CTD |
PMID:23041323 |
|
NCBI chr 9:83,309,895...83,312,397
Ensembl chr 9:83,311,246...83,315,608
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
increases phosphorylation
|
ISO
|
Serotonin results in increased phosphorylation of GSK3B protein
|
CTD |
PMID:20190034 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions
|
ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]
|
CTD |
PMID:26408985 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
G
|
Htr1a
|
5-hydroxytryptamine receptor 1A
|
multiple interactions increases activity affects binding increases uptake increases expression affects response to substance
|
EXP ISO
|
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein] Serotonin results in increased activity of HTR1A protein Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]; Serotonin binds to and results in increased activity of HTR1A protein Serotonin results in increased expression of HTR1A mRNA HTR1A protein affects the susceptibility to Serotonin
|
CTD |
PMID:11106871 PMID:16528294 PMID:21083617 PMID:21126535 PMID:30102254 PMID:31323226 More...
|
|
NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
|
|
G
|
Htr1b
|
5-hydroxytryptamine receptor 1B
|
affects binding multiple interactions
|
EXP ISO
|
Serotonin binds to HTR1B protein Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1B protein]; Serotonin binds to and results in increased activity of HTR1B protein
|
CTD |
PMID:11888550 PMID:30102254 |
|
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:91,052,432...91,418,583
|
|
G
|
Htr1d
|
5-hydroxytryptamine receptor 1D
|
affects abundance
|
ISO
|
HTR1D gene polymorphism affects the abundance of Serotonin
|
CTD |
PMID:17203304 |
|
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:153,939,516...153,960,012
|
|
G
|
Htr1f
|
5-hydroxytryptamine receptor 1F
|
multiple interactions
|
ISO
|
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1F protein]; Serotonin binds to and results in increased activity of HTR1F protein
|
CTD |
PMID:30102254 |
|
NCBI chr11:2,642,751...2,644,150
Ensembl chr11:16,081,053...16,274,580
|
|
G
|
Htr2a
|
5-hydroxytryptamine receptor 2A
|
decreases response to substance affects response to substance affects binding increases expression multiple interactions
|
ISO EXP
|
HTR2A gene SNP results in decreased susceptibility to Serotonin HTR2A protein affects the susceptibility to Serotonin Serotonin binds to HTR2A protein Serotonin results in increased expression of HTR2A mRNA [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein
|
CTD |
PMID:8627522 PMID:11076827 PMID:11880652 PMID:16314884 PMID:16528294 PMID:19879056 PMID:21083617 More...
|
|
NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
|
|
G
|
Htr2b
|
5-hydroxytryptamine receptor 2B
|
increases expression affects binding multiple interactions affects response to substance
|
ISO EXP
|
Serotonin results in increased expression of HTR2B mRNA Serotonin binds to HTR2B protein 1-(5-fluoropentyl)-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [Serotonin binds to HTR2B protein]; 1-pentyl-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; JWH-073 inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; Serotonin binds to and results in increased activity of HTR2B protein HTR2B protein affects the susceptibility to Serotonin
|
CTD |
PMID:8627522 PMID:9857084 PMID:21083617 PMID:27449567 |
|
NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:94,190,109...94,204,087
|
|
G
|
Htr2c
|
5-hydroxytryptamine receptor 2C
|
affects expression multiple interactions
|
ISO EXP
|
Serotonin affects the expression of HTR2C mRNA [Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]; Serotonin binds to and results in increased activity of HTR2C protein
|
CTD |
PMID:9050900 PMID:21083617 PMID:21554931 |
|
NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324
|
|
G
|
Htr3a
|
5-hydroxytryptamine receptor 3A
|
multiple interactions increases activity affects localization
|
ISO EXP
|
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein] Serotonin affects the localization of HTR3A protein alternative form 1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Toluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Trichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]
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CTD |
PMID:12681521 PMID:17360702 PMID:17436349 PMID:32209479 |
|
NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
|
|
G
|
Htr3b
|
5-hydroxytryptamine receptor 3B
|
multiple interactions
|
ISO
|
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]
|
CTD |
PMID:17360702 |
|
NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:58,175,101...58,204,939
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|
G
|
Htr4
|
5-hydroxytryptamine receptor 4
|
multiple interactions
|
ISO
|
HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]
|
CTD |
PMID:11880652 |
|
NCBI chr18:55,765,981...55,949,921
Ensembl chr18:58,036,277...58,219,622
|
|
G
|
Htr6
|
5-hydroxytryptamine receptor 6
|
multiple interactions
|
ISO
|
HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP]
|
CTD |
PMID:11406289 PMID:11880652 |
|
NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147
|
|
G
|
Htr7
|
5-hydroxytryptamine receptor 7
|
multiple interactions
|
ISO
|
[Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP
|
CTD |
PMID:14578406 |
|
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:243,049,081...243,173,230
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|
G
|
Il12b
|
interleukin 12B
|
affects secretion
|
ISO
|
Serotonin affects the secretion of IL12B protein
|
CTD |
PMID:15802305 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
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|
G
|
Il13
|
interleukin 13
|
affects response to substance
|
ISO
|
IL13 protein affects the susceptibility to Serotonin
|
CTD |
PMID:12370375 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
|
|
G
|
Il1b
|
interleukin 1 beta
|
affects secretion multiple interactions increases expression
|
ISO
|
Serotonin affects the secretion of IL1B protein anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein] Serotonin results in increased expression of IL1B
|
CTD |
PMID:15302781 PMID:15802305 PMID:30611738 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il4
|
interleukin 4
|
affects response to substance
|
ISO
|
IL4 protein affects the susceptibility to Serotonin
|
CTD |
PMID:12370375 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
G
|
Il6
|
interleukin 6
|
affects expression multiple interactions increases expression affects secretion
|
ISO
|
Serotonin affects the expression of IL6 mRNA anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein] Serotonin results in increased expression of IL6 mRNA [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein Serotonin affects the secretion of IL6 protein
|
CTD |
PMID:11076827 PMID:15302781 PMID:15802305 PMID:30611738 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Irs1
|
insulin receptor substrate 1
|
multiple interactions
|
ISO
|
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]
|
CTD |
PMID:22975078 |
|
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
|
|
G
|
Itga2
|
integrin subunit alpha 2
|
multiple interactions
|
ISO EXP
|
ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]
|
CTD |
PMID:18234883 |
|
NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509
|
|
G
|
Itgam
|
integrin subunit alpha M
|
increases expression
|
ISO
|
Serotonin increases expression of Itgam protein on neutrophils
|
RGD |
PMID:30586717 |
RGD:329853774 |
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
|
|
G
|
Itgb3
|
integrin subunit beta 3
|
affects abundance
|
ISO
|
ITGB3 gene polymorphism affects the abundance of Serotonin
|
CTD |
PMID:16724005 PMID:17203304 |
|
NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800
|
|
G
|
Kcnk3
|
potassium two pore domain channel subfamily K member 3
|
multiple interactions
|
EXP
|
Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium]
|
CTD |
PMID:16020457 |
|
NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061
|
|
G
|
Kng1
|
kininogen 1
|
multiple interactions
|
EXP
|
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]
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CTD |
PMID:11166334 PMID:12791437 PMID:18234883 |
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NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148
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G
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Maoa
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monoamine oxidase A
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increases metabolic processing multiple interactions increases degradation decreases amination increases abundance
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ISO EXP
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MAOA protein results in increased metabolism of Serotonin [MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid MAOA protein results in increased degradation of Serotonin [MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde; Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]; Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin] MAOA protein results in decreased amination of Serotonin 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Isocarboxazid inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin] MAOA mutant form results in increased abundance of Serotonin MAOA gene polymorphism results in increased abundance of Serotonin
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CTD |
PMID:3961266 PMID:10647887 PMID:11834493 PMID:18405062 PMID:23009399 PMID:26721607 PMID:30036687 PMID:32243540 More...
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NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631
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G
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Maob
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monoamine oxidase B
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increases abundance decreases amination multiple interactions
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ISO
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MAOB mutant form results in increased abundance of Serotonin MAOB protein results in decreased amination of Serotonin 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]
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CTD |
PMID:11834493 PMID:26721607 |
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NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375
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G
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Mapk1
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mitogen activated protein kinase 1
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increases phosphorylation
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ISO
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Serotonin results in increased phosphorylation of MAPK1 protein
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CTD |
PMID:30592962 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
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Mapk3
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mitogen activated protein kinase 3
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increases phosphorylation
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ISO
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Serotonin results in increased phosphorylation of MAPK3 protein
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CTD |
PMID:30592962 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
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Mmp20
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matrix metallopeptidase 20
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decreases expression
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ISO
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Serotonin results in decreased expression of MMP20 mRNA
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CTD |
PMID:21083617 |
|
NCBI chr 8:4,789,415...4,830,035
Ensembl chr 8:13,074,279...13,114,894
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G
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Mpo
|
myeloperoxidase
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multiple interactions
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ISO
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[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]
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CTD |
PMID:23009681 PMID:30611738 |
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NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
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G
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Mt1a
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metallothionein 1A
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multiple interactions
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ISO
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[MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin
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CTD |
PMID:18226494 |
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NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200 Ensembl chr X:79,695,809...79,696,200 Ensembl chr19:79,695,809...79,696,200
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G
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Mt2
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metallothionein 2
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multiple interactions
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ISO
|
[MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin
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CTD |
PMID:18226494 |
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NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
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G
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Mtor
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mechanistic target of rapamycin kinase
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multiple interactions increases activity
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ISO
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sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein]
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CTD |
PMID:27133527 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
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G
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Myl2
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myosin light chain 2
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increases phosphorylation multiple interactions
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EXP
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Serotonin results in increased phosphorylation of MYL2 protein cyclocurcumin inhibits the reaction [Serotonin results in increased phosphorylation of MYL2 protein]
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CTD |
PMID:28068085 |
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NCBI chr12:40,114,964...40,126,236
Ensembl chr12:40,114,958...40,129,149
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G
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Napepld
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N-acyl phosphatidylethanolamine phospholipase D
|
multiple interactions
|
ISO
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GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]
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CTD |
PMID:30611738 |
|
NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014
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G
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Nos2
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nitric oxide synthase 2
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multiple interactions
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ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]
|
CTD |
PMID:26408985 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
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Nqo1
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NAD(P)H quinone dehydrogenase 1
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multiple interactions
|
ISO
|
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein]
|
CTD |
PMID:26408985 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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G
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Oprd1
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opioid receptor, delta 1
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multiple interactions
|
EXP
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[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
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CTD |
PMID:7562497 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
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G
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Oprk1
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opioid receptor, kappa 1
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multiple interactions
|
EXP
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[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
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CTD |
PMID:7562497 |
|
NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
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G
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Oprm1
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opioid receptor, mu 1
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multiple interactions
|
EXP
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[dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
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CTD |
PMID:7562497 |
|
NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
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G
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Otc
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ornithine transcarbamylase
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affects metabolic processing multiple interactions
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ISO
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OTC gene mutant form affects the metabolism of Serotonin Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]
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CTD |
PMID:3374991 |
|
NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555
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G
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Oxt
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oxytocin/neurophysin I prepropeptide
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increases secretion
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ISO
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OXT protein results in increased secretion of Serotonin
|
CTD |
PMID:19228979 |
|
NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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affects abundance
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ISO
|
PARP1 affects the abundance of Serotonin
|
CTD |
PMID:21990073 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
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G
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Penk
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proenkephalin
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multiple interactions
|
EXP
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Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA]
|
CTD |
PMID:1363325 |
|
NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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increases localization multiple interactions
|
ISO
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Serotonin results in increased localization of PPARG protein [Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein]
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CTD |
PMID:25766885 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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G
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Ppp1r1b
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protein phosphatase 1, regulatory (inhibitor) subunit 1B
|
multiple interactions increases phosphorylation decreases phosphorylation
|
ISO
|
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
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CTD |
PMID:11880652 |
|
NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions increases expression
|
ISO EXP
|
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] Serotonin results in increased expression of PTGS2 mRNA; Serotonin results in increased expression of PTGS2 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; AG 1879 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; Calcium deficiency inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
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CTD |
PMID:21262218 PMID:26408985 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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increases activity
|
ISO
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Serotonin results in increased activity of RELA protein
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CTD |
PMID:11076827 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
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Serpine2
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serpin family E member 2
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multiple interactions
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ISO
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[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
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CTD |
PMID:24107419 PMID:27097221 |
|
NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202
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G
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Slc18a1
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solute carrier family 18 member A1
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multiple interactions increases uptake
|
ISO
|
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]
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CTD |
PMID:8245983 |
|
NCBI chr16:25,408,485...25,453,786
Ensembl chr16:25,420,243...25,453,786
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G
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Slc18a2
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solute carrier family 18 member A2
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affects binding increases uptake increases transport multiple interactions affects uptake
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ISO EXP
|
Serotonin binds to SLC18A2 protein Serotonin binds to Slc8a2 protein SLC18A2 protein binds to Serotonin SLC18A2 protein results in increased uptake of Serotonin SLC18A2 protein results in increased transport of Serotonin Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin] SLC18A2 gene SNP affects the uptake of Serotonin
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CTD RGD |
PMID:1438304 PMID:7912402 PMID:9038139 PMID:15475732 PMID:18287335 PMID:20007701 More...
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RGD:5130957 |
NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231
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G
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Slc22a16
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solute carrier family 22 member 16
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multiple interactions
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ISO
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Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]
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CTD |
PMID:15963465 |
|
NCBI chr20:43,972,808...44,068,447
Ensembl chr20:45,527,315...45,648,475
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G
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Slc22a3
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solute carrier family 22 member 3
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multiple interactions increases uptake
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EXP ISO
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Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A3 protein results in increased uptake of Serotonin
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CTD |
PMID:9830022 PMID:16928864 PMID:20858707 |
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NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353
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G
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Slc29a4
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solute carrier family 29 member 4
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increases uptake
|
ISO
|
SLC29A4 protein results in increased uptake of Serotonin
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CTD |
PMID:20858707 |
|
NCBI chr12:11,853,540...11,884,660
Ensembl chr12:16,967,047...16,988,338
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G
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Slc47a1
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solute carrier family 47 member 1
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multiple interactions
|
ISO
|
Serotonin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
|
CTD |
PMID:22419765 |
|
NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
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G
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Slc47a2
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solute carrier family 47 member 2
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multiple interactions
|
ISO
|
Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
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CTD |
PMID:22419765 |
|
NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
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G
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Slc6a2
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solute carrier family 6 member 2
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multiple interactions
|
ISO
|
SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
|
CTD |
PMID:17234900 |
|
NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348
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G
|
Slc6a3
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solute carrier family 6 member 3
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multiple interactions increases uptake
|
ISO
|
SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] SLC6A3 protein results in increased uptake of Serotonin
|
CTD |
PMID:17234900 PMID:17250655 |
|
NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
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G
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Slc6a4
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solute carrier family 6 member 4
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multiple interactions increases activity decreases activity increases uptake affects binding increases expression affects abundance
|
ISO EXP
|
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] serotonin decreases activity of Slc6a4 protein in epithelial colorectal adenocarcinoma cells Serotonin binds to SLC6A4 protein 4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Aminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Dextroamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin] Serotonin results in increased expression of SLC6A4 mRNA SLC6A4 gene polymorphism affects the abundance of Serotonin
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CTD RGD |
PMID:15972295 PMID:16272152 PMID:16476009 PMID:16982082 PMID:17203304 PMID:17234900 PMID:20452607 PMID:21083617 PMID:24841869 PMID:29908239 PMID:30776375 PMID:33785354 PMID:19747920 More...
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RGD:36947380 |
NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056
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G
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Sorl1
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sortilin related receptor 1
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multiple interactions increases expression
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ISO
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sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA]
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CTD |
PMID:24650663 |
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NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446
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G
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Stxbp3
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syntaxin binding protein 3
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affects secretion
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ISO
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STXBP3 protein affects the secretion of Serotonin
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CTD |
PMID:18556422 |
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NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:199,130,725...199,173,823
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G
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Sult1a1
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sulfotransferase family 1A member 1
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increases sulfation
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ISO EXP
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SULT1A1 protein results in increased sulfation of Serotonin
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CTD |
PMID:11181495 |
|
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
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G
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Taar1
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trace-amine-associated receptor 1
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multiple interactions
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ISO
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SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
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CTD |
PMID:17234900 |
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NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:23,335,165...23,353,981
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G
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Tac1
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tachykinin, precursor 1
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multiple interactions
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EXP
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Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]
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CTD |
PMID:11166334 PMID:18234883 |
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NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
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G
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Tdo2
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tryptophan 2,3-dioxygenase
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multiple interactions
|
EXP
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[Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
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CTD |
PMID:16952380 |
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NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions
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ISO
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[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
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CTD |
PMID:24107419 PMID:27097221 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Tnf
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tumor necrosis factor
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affects secretion multiple interactions increases expression
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ISO
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Serotonin affects the secretion of TNF protein [Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein; anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]; glyceryl 2-arachidonate inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein] Serotonin results in increased expression of TNF
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CTD |
PMID:15302781 PMID:15802305 PMID:30611738 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
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Tph1
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tryptophan hydroxylase 1
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affects abundance multiple interactions increases chemical synthesis increases abundance
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ISO
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TPH1 gene polymorphism affects the abundance of Serotonin Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]]; Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein] TPH1 protein results in increased chemical synthesis of Serotonin TPH1 gene polymorphism results in increased abundance of Serotonin
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CTD |
PMID:17203304 PMID:18405062 PMID:18506000 PMID:30611738 |
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NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:106,085,953...106,312,484
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G
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Tph2
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tryptophan hydroxylase 2
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affects abundance
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ISO
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TPH2 protein affects the abundance of Serotonin
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CTD |
PMID:20722968 |
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NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639
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G
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Trpa1
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transient receptor potential cation channel, subfamily A, member 1
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multiple interactions
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ISO
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TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin]
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CTD |
PMID:19507004 |
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NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325
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G
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Trpv1
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transient receptor potential cation channel, subfamily V, member 1
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multiple interactions
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EXP
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Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium]
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CTD |
PMID:16901936 |
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NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
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G
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Trpv4
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transient receptor potential cation channel, subfamily V, member 4
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multiple interactions
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ISO
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TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
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CTD |
PMID:18234883 |
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NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143
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G
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Ugt1a6
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UDP glucuronosyltransferase family 1 member A6
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increases glucuronidation affects glucuronidation multiple interactions
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ISO
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UGT1A6 protein results in increased glucuronidation of Serotonin; UGT1A6 protein results in increased glucuronidation of Serotonin metabolite UGT1A6 gene polymorphism affects the glucuronidation of Serotonin; UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]
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CTD |
PMID:15761113 PMID:15761114 PMID:18214896 |
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NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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G
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Vcam1
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vascular cell adhesion molecule 1
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multiple interactions
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ISO
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[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein; sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein]
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CTD |
PMID:22785018 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
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G
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Xdh
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xanthine dehydrogenase
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multiple interactions
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ISO
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[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine]
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CTD |
PMID:23009681 |
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NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
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G
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Ywhab
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
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multiple interactions
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ISO
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[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]
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CTD |
PMID:22975078 |
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NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854
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G
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Bdnf
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brain-derived neurotrophic factor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of BDNF protein]
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CTD |
PMID:22150557 |
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NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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G
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Calca
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calcitonin-related polypeptide alpha
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multiple interactions decreases expression
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ISO EXP
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Sumatriptan results in decreased expression of and results in decreased secretion of CALCA protein Sumatriptan results in decreased expression of CALCA mRNA 3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; isamoltane inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]
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CTD |
PMID:12574409 PMID:14715155 PMID:15689192 |
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NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
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G
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Casp3
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caspase 3
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multiple interactions
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EXP
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Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
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CTD |
PMID:29958920 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Ccl2
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C-C motif chemokine ligand 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CCL2 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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G
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Ccl20
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C-C motif chemokine ligand 20
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
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G
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Ccl22
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C-C motif chemokine ligand 22
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]
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CTD |
PMID:22150557 |
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NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359
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G
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Ccl3
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C-C motif chemokine ligand 3
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
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G
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Ccr4
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C-C motif chemokine receptor 4
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]
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CTD |
PMID:22150557 |
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NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642
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G
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Cd80
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Cd80 molecule
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein]
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CTD |
PMID:22150557 |
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NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540
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G
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Cilk1
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ciliogenesis associated kinase 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 8:87,868,294...87,922,995
Ensembl chr 8:87,868,156...87,922,995
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G
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Cntf
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ciliary neurotrophic factor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein]
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CTD |
PMID:22150557 |
|
NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
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G
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Cntfr
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ciliary neurotrophic factor receptor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]
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CTD |
PMID:22150557 |
|
NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:61,619,326...61,645,795
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G
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Csf2
|
colony stimulating factor 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
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G
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Ctnnb1
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catenin beta 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]
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CTD |
PMID:22150557 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
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G
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Cx3cl1
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C-X3-C motif chemokine ligand 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]
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CTD |
PMID:22150557 |
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NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
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G
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Cxcl10
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C-X-C motif chemokine ligand 10
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]
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CTD |
PMID:22150557 |
|
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
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G
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Cxcl2
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C-X-C motif chemokine ligand 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]
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CTD |
PMID:22150557 |
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NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
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G
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Cxcl6
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C-X-C motif chemokine ligand 6
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]
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CTD |
PMID:22150557 |
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NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417
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G
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Cxcr4
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C-X-C motif chemokine receptor 4
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]
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CTD |
PMID:22150557 |
|
NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
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G
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Errfi1
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ERBB receptor feedback inhibitor 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432
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G
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Fadd
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Fas associated via death domain
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein]
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CTD |
PMID:22150557 |
|
NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976
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G
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Fas
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Fas cell surface death receptor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FAS protein]
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CTD |
PMID:22150557 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
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G
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Faslg
|
Fas ligand
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FASLG protein]
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CTD |
PMID:22150557 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
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G
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Fgfbp1
|
fibroblast growth factor binding protein 1
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr14:71,316,171...71,319,965
Ensembl chr14:71,317,065...71,320,309
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G
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Fgl1
|
fibrinogen-like 1
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429
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G
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Fos
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Fos proto-oncogene, AP-1 transcription factor subunit
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multiple interactions
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ISO
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Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FOS protein]
|
CTD |
PMID:12110114 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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G
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Fstl1
|
follistatin-like 1
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126
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G
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Gfra1
|
GDNF family receptor alpha 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501
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G
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Gfra2
|
GDNF family receptor alpha 2
|
multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr15:45,941,841...46,033,715
Ensembl chr15:52,351,514...52,477,782
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G
|
Gh1
|
growth hormone 1
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859
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G
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Ghr
|
growth hormone receptor
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331
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G
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Hcrt
|
hypocretin neuropeptide precursor
|
multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524
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|
G
|
Htr1b
|
5-hydroxytryptamine receptor 1B
|
multiple interactions affects binding
|
EXP
|
Sumatriptan binds to and results in increased activity of HTR1B protein Sumatriptan binds to HTR1B protein
|
CTD |
PMID:11301495 PMID:11888550 |
|
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:91,052,432...91,418,583
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G
|
Htr1d
|
5-hydroxytryptamine receptor 1D
|
multiple interactions
|
EXP
|
Sumatriptan binds to and results in increased activity of HTR1D protein
|
CTD |
PMID:11301495 |
|
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:153,939,516...153,960,012
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G
|
Ide
|
insulin degrading enzyme
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526
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G
|
Ifng
|
interferon gamma
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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G
|
Il10
|
interleukin 10
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL10 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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G
|
Il13
|
interleukin 13
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
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G
|
Il1a
|
interleukin 1 alpha
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of IL1B mRNA]
|
CTD |
PMID:22150557 PMID:29958920 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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|
G
|
Il2
|
interleukin 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
|
|
G
|
Il3
|
interleukin 3
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,906,460...38,908,810
|
|
G
|
Il4
|
interleukin 4
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL4 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
G
|
Il5
|
interleukin 5
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL5 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Inhba
|
inhibin subunit beta A
|
multiple interactions
|
EXP
|
Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INHBA protein]
|
CTD |
PMID:22150557 |
|
NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INS1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Lep
|
leptin
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
|
|
G
|
Map2k1
|
mitogen activated protein kinase kinase 1
|
multiple interactions
|
EXP
|
[Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]
|
CTD |
PMID:12574409 |
|
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184
|
|
G
|
Mif
|
macrophage migration inhibitory factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein]
|
CTD |
PMID:22150557 |
|
NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121 Ensembl chr20:134,041,774...134,042,121
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|
G
|
Mmp13
|
matrix metallopeptidase 13
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Musk
|
muscle associated receptor tyrosine kinase
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:77,853,736...77,964,338
|
|
G
|
Ngf
|
nerve growth factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]
|
CTD |
PMID:12574409 PMID:22150557 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
|
|
G
|
Ngfr
|
nerve growth factor receptor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305
|
|
G
|
Nos1
|
nitric oxide synthase 1
|
multiple interactions
|
EXP
|
Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]
|
CTD |
PMID:14510930 |
|
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
|
|
G
|
Nr0b2
|
nuclear receptor subfamily 0, group B, member 2
|
decreases expression
|
ISO
|
Sumatriptan results in decreased expression of NR0B2 mRNA
|
CTD |
PMID:15342952 |
|
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475
|
|
G
|
Nrp1
|
neuropilin 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702
|
|
G
|
Pdgfa
|
platelet derived growth factor subunit A
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]
|
CTD |
PMID:22150557 |
|
NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322
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|
G
|
Plin2
|
perilipin 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878
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|
G
|
Pomc
|
proopiomelanocortin
|
decreases expression multiple interactions
|
ISO EXP
|
Sumatriptan results in decreased expression of POMC protein modified form [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]
|
CTD |
PMID:7640145 PMID:22150557 |
|
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
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|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
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|
G
|
Prlr
|
prolactin receptor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of PRLR protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882
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|
G
|
Prok1
|
prokineticin 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:197,537,068...197,547,550
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
Sumatriptan inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein]
|
CTD |
PMID:29958920 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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|
G
|
Retn
|
resistin
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETN protein]
|
CTD |
PMID:22150557 |
|
NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116
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|
G
|
Retnlb
|
resistin like beta
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]
|
CTD |
PMID:22150557 |
|
NCBI chr11:65,446,433...65,448,319
Ensembl chr11:65,446,434...65,448,319
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|
G
|
Sele
|
selectin E
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELE protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
|
|
G
|
Sell
|
selectin L
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
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|
G
|
Spp1
|
secreted phosphoprotein 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Sumatriptan promotes the reaction [Capsaicin results in increased expression of SPP1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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|
G
|
Tal1
|
TAL bHLH transcription factor 1, erythroid differentiation factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738
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|
G
|
Tek
|
TEK receptor tyrosine kinase
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:114,723,006...114,849,991
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|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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|
G
|
Tgfb2
|
transforming growth factor, beta 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
|
|
G
|
Tgfb3
|
transforming growth factor, beta 3
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946
|
|
G
|
Timp1
|
TIMP metallopeptidase inhibitor 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
|
|
G
|
Timp2
|
TIMP metallopeptidase inhibitor 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
|
|
G
|
Timp3
|
TIMP metallopeptidase inhibitor 3
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of TNF mRNA]
|
CTD |
PMID:22150557 PMID:29958920 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tnfrsf19
|
TNF receptor superfamily member 19
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438
|
|
G
|
Tnfsf10
|
TNF superfamily member 10
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:112,136,550...112,155,903
|
|
G
|
Vcam1
|
vascular cell adhesion molecule 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of VEGFA protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|
|
G
|
Gast
|
gastrin
|
decreases cleavage
|
EXP
|
tryptamine results in decreased cleavage of GAST protein
|
CTD |
PMID:10332097 |
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NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880
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G
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Htr2a
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5-hydroxytryptamine receptor 2A
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decreases response to substance affects response to substance multiple interactions
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ISO
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HTR2A gene SNP results in decreased susceptibility to tryptamine HTR2A protein affects the susceptibility to tryptamine tryptamine binds to and results in increased activity of HTR2A protein
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CTD |
PMID:16314884 |
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NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
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G
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Maoa
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monoamine oxidase A
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decreases amination multiple interactions
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ISO
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MAOA protein results in decreased amination of tryptamine [[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde
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CTD |
PMID:26686552 |
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NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631
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G
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Maob
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monoamine oxidase B
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multiple interactions decreases amination
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ISO
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[[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde
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CTD |
PMID:26686552 |
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NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375
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G
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Nr1i2
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nuclear receptor subfamily 1, group I, member 2
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increases activity
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ISO
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tryptamine results in increased activity of NR1I2 protein
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CTD |
PMID:33002526 |
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NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
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G
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Slc6a2
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solute carrier family 6 member 2
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multiple interactions
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ISO
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Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]
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CTD |
PMID:17234900 |
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NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348
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G
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Slc6a3
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solute carrier family 6 member 3
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multiple interactions
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ISO
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indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]
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CTD |
PMID:17234900 |
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NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
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G
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Slc6a4
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solute carrier family 6 member 4
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multiple interactions
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ISO
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Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]
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CTD |
PMID:17234900 |
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NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056
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G
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Taar1
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trace-amine-associated receptor 1
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multiple interactions increases activity
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ISO
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[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]
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CTD |
PMID:17234900 PMID:19725810 |
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NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:23,335,165...23,353,981
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G
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Ace2
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angiotensin converting enzyme 2
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increases expression
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EXP
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tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596
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G
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Agtr1a
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angiotensin II receptor, type 1a
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increases expression
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EXP
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tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
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G
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Ahrr
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aryl-hydrocarbon receptor repressor
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decreases expression
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EXP
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tryptophan in pregnant dams decreases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866
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G
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Arnt
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aryl hydrocarbon receptor nuclear translocator
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increases expression
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EXP
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tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
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G
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Atp6ap2
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ATPase H+ transporting accessory protein 2
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increases expression
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EXP
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tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr X:12,856,708...12,883,670
Ensembl chr X:12,855,859...12,905,875
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G
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Tiparp
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TCDD-inducible poly(ADP-ribose) polymerase
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increases expression
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EXP
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tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring
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RGD |
PMID:32604820 |
RGD:401793718 |
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:152,063,751...152,090,406
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G
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Casp2
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caspase 2
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increases activity
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ISO
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violacein results in increased activity of CASP2 protein
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CTD |
PMID:20416285 |
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NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
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G
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Casp3
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caspase 3
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increases activity
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ISO
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violacein results in increased activity of CASP3 protein
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CTD |
PMID:20416285 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Casp9
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caspase 9
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increases activity
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ISO
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violacein results in increased activity of CASP9 protein
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CTD |
PMID:20416285 |
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Ensembl chr 5:159,391,188...159,409,648
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G
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Bad
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BCL2-associated agonist of cell death
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD protein]
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CTD |
PMID:31129132 |
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NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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G
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Bax
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BCL2 associated X, apoptosis regulator
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]
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CTD |
PMID:31129132 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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G
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Bcl2
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BCL2, apoptosis regulator
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]
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CTD |
PMID:31129132 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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G
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Bcl2l1
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Bcl2-like 1
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]
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CTD |
PMID:31129132 |
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NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
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G
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Casp3
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caspase 3
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein]
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CTD |
PMID:31129132 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Casp9
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caspase 9
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein]
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CTD |
PMID:31129132 |
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Ensembl chr 5:159,391,188...159,409,648
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G
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Cyp1a2
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cytochrome P450, family 1, subfamily a, polypeptide 2
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decreases activity
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ISO
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zolmitriptan results in decreased activity of CYP1A2 protein
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CTD |
PMID:18816299 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
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G
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Gpt
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glutamic--pyruvic transaminase
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
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CTD |
PMID:31129132 |
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NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
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G
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Nos2
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nitric oxide synthase 2
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 mRNA]
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CTD |
PMID:31129132 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
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Nos3
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nitric oxide synthase 3
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multiple interactions
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EXP
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zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of NOS3 mRNA]
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CTD |
PMID:31129132 |
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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G
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Snca
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synuclein alpha
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multiple interactions
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EXP
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Dextromethorphan promotes the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; Glutamic Acid inhibits the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]
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CTD |
PMID:38229316 |
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NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
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