CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: triazole
Accession: CHEBI:38597
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Synonyms: related_synonym: Formula=C2H3N3
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Afp
alpha-fetoprotein
multiple interactions
EXP
1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]
CTD
PMID:28693887
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Car1
carbonic anhydrase 1
decreases activity
ISO
1,2,4-triazole analog results in decreased activity of CA1 protein
CTD
PMID:30368973
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
1,2,4-triazole analog results in decreased activity of CA2 protein
CTD
PMID:30368973
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Ephb4
EPH receptor B4
multiple interactions
EXP
1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]
CTD
PMID:28693887
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]
CTD
PMID:28693887
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of VEGFA protein]
CTD
PMID:28693887
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Abcb9
ATP binding cassette subfamily B member 9
decreases expression
EXP
Fluconazole results in decreased expression of ABCB9 mRNA
CTD
PMID:16643972
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases expression
EXP
Fluconazole results in decreased expression of ADH1 mRNA
CTD
PMID:16643972
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Akr7a3
aldo-keto reductase family 7 member A3
increases expression
EXP
Fluconazole results in increased expression of AKR7A3 mRNA
CTD
PMID:16643972
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Apoa4
apolipoprotein A4
decreases expression
EXP
Fluconazole results in decreased expression of APOA4 mRNA
CTD
PMID:16643972
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Ces2h
carboxylesterase 2H
increases expression
EXP
Fluconazole results in increased expression of CES2 mRNA
CTD
PMID:16643972
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects activity
ISO
Fluconazole affects the activity of CYP17A1 protein
CTD
PMID:31330226
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions decreases activity
ISO
[Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione
CTD
PMID:31330226
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
Fluconazole results in increased expression of CYP1A2 mRNA
CTD
PMID:16730040
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
ISO
Fluconazole results in increased expression of CYP26A1 mRNA
CTD
PMID:19429397
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
increases expression
ISO
Fluconazole results in increased expression of CYP26B1 mRNA
CTD
PMID:19429397
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions increases expression
ISO
NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]
CTD
PMID:16730040 PMID:25656644
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
Fluconazole results in decreased expression of CYP2C mRNA
CTD
PMID:16643972
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
increases expression
ISO
Fluconazole results in increased expression of CYP2C55 mRNA
CTD
PMID:16730040
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity increases metabolic processing multiple interactions increases expression
ISO
Fluconazole results in decreased activity of CYP2C19 protein CYP2C19 protein results in increased metabolism of Fluconazole [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole Fluconazole results in increased expression of CYP2C29 mRNA
CTD
PMID:12464242 PMID:15843491 PMID:16730040 PMID:17702393 PMID:19328226 PMID:26599973 More...
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2g1
cytochrome P450, family 2, subfamily g, polypeptide 1
decreases expression
EXP
Fluconazole results in decreased expression of CYP2G1 mRNA
CTD
PMID:16643972
NCBI chr 1:82,145,635...82,156,862
Ensembl chr 1:82,145,073...82,156,828
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
decreases expression
ISO
Fluconazole results in decreased expression of CYP2J9 mRNA
CTD
PMID:16730040
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity increases expression multiple interactions
ISO
Fluconazole results in decreased activity of CYP3A4 protein Fluconazole results in increased expression of CYP3A11 mRNA NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP3A11 mRNA]
CTD
PMID:15784650 PMID:15843491 PMID:16730040 PMID:25656644
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression affects expression
EXP
Fluconazole results in increased expression of CYP3A23-3A1 mRNA Fluconazole affects the expression of CYP3A23-3A1 mRNA
CTD
PMID:16643972 PMID:20623750
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
EXP
Fluconazole results in increased expression of CYP3A13 mRNA
CTD
PMID:16643972
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp51
cytochrome P450, family 51
decreases activity multiple interactions decreases response to substance
ISO
Fluconazole results in decreased activity of CYP51A1 protein CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol] CYP51A1 gene results in decreased susceptibility to Fluconazole
CTD
PMID:16989930 PMID:18694951
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Gstm1
glutathione S-transferase mu 1
increases expression
ISO
Fluconazole results in increased expression of GSTM1 mRNA
CTD
PMID:16730040
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Fluconazole results in decreased expression of JUND mRNA
CTD
PMID:16643972
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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Lcn2
lipocalin 2
increases expression
EXP
Fluconazole results in increased expression of LCN2 mRNA
CTD
PMID:20623750
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mark2
microtubule affinity regulating kinase 2
increases expression
ISO
Fluconazole results in increased expression of MARK2 mRNA
CTD
PMID:16730040
NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652
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Mpo
myeloperoxidase
increases expression
EXP
Fluconazole results in increased expression of MPO mRNA
CTD
PMID:20623750
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Fluconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
CTD
PMID:17438109
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
affects response to substance multiple interactions increases response to substance
ISO
NR1I3 protein affects the susceptibility to Fluconazole NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP3A11 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA] NR1I3 results in increased susceptibility to Fluconazole
CTD
PMID:23721867 PMID:25656644
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Por
cytochrome p450 oxidoreductase
decreases expression increases expression multiple interactions
EXP ISO
Fluconazole results in decreased expression of POR mRNA Fluconazole results in increased expression of POR mRNA NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]
CTD
PMID:16643972 PMID:16730040 PMID:25656644
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
EXP
Fluconazole results in increased expression of PPARG mRNA
CTD
PMID:20623750
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Slc13a2
solute carrier family 13 member 2
decreases expression
ISO
Fluconazole results in decreased expression of SLC13A2 mRNA
CTD
PMID:16730040
NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
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Slc6a13
solute carrier family 6 member 13
decreases expression
EXP
Fluconazole results in decreased expression of SLC6A13 mRNA
CTD
PMID:16643972
NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
ISO
Fluconazole results in increased expression of SLCO1A4 mRNA
CTD
PMID:16730040
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Srd5a1
steroid 5 alpha-reductase 1
decreases expression
EXP
Fluconazole results in decreased expression of SRD5A1 mRNA
CTD
PMID:16643972
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Star
steroidogenic acute regulatory protein
increases expression
ISO
Fluconazole results in increased expression of STAR mRNA
CTD
PMID:23038793
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
affects expression
EXP
Fluconazole affects the expression of UGT1A9 mRNA
CTD
PMID:20623750
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Fluconazole results in increased expression of UGT2B1 mRNA
CTD
PMID:16643972
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
multiple interactions
ISO
Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]
CTD
PMID:18098064
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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