pyrrolizines - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pyrrolizines	go back to main search page
Accession:	CHEBI:38522	browse the term

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Rat (831) Mouse (835) Human (844) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (831)

Echimidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

increases expression

echimidine results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

actinin alpha 2

decreases expression

echimidine results in decreased expression of ACTN2 mRNA

NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622

G

ADAM metallopeptidase domain 8

increases expression

echimidine results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

aldehyde dehydrogenase 1 family, member A1

increases expression

echimidine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

anaphase promoting complex subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of ANAPC2 mRNA

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

ankyrin repeat domain 1

decreases expression

echimidine results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

aurora kinase A

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

complement C3a receptor 1

increases expression

echimidine results in increased expression of C3AR1 mRNA

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

caspase 3

multiple interactions

echimidine results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

echimidine results in increased activity of and results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

echimidine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin B1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cell division cycle 16

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 20

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25B

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cyclin-dependent kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

echimidine results in increased expression of CDKN1A mRNA
[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of CDKN1A mRNA

PMID:32419051 PMID:33884520

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

cytoskeleton associated protein 2

increases expression

echimidine results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase, M-type

decreases expression

echimidine results in decreased expression of CKM mRNA

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

creatine kinase, mitochondrial 2

decreases expression

echimidine results in decreased expression of CKMT2 mRNA

NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430

G

C-type lectin domain family 4, member F

decreases expression

echimidine results in decreased expression of CLEC4F mRNA

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

cytochrome c oxidase subunit 6A2

decreases expression

echimidine results in decreased expression of COX6A2 mRNA

NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274

G

colony stimulating factor 1 receptor

decreases expression

echimidine results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine rich protein 3

decreases expression

echimidine results in decreased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases response to substance
multiple interactions

CYP3A4 protein results in increased metabolism of echimidine
CYP3A4 protein results in increased susceptibility to echimidine
[CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PPP2R5D mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of CDC16 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PPP2R5E mRNA

PMID:32910235 PMID:33884520

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

deoxyribonuclease 1L3

decreases expression

echimidine results in decreased expression of DNASE1L3 mRNA

NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317

G

ectodysplasin A2 receptor

increases expression

echimidine results in increased expression of EDA2R mRNA

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

eukaryotic translation elongation factor 1 alpha 2

decreases expression

echimidine results in decreased expression of EEF1A2 mRNA

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

extra spindle pole bodies like 1, separase

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

Fas cell surface death receptor

increases expression

echimidine metabolite results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box protein 5

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

Fc gamma receptor 3A

increases expression

echimidine results in increased expression of FCGR3A mRNA

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

glypican 1

decreases expression

echimidine results in decreased expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

H2A.X variant histone

increases expression

echimidine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hemojuvelin BMP co-receptor

decreases expression

echimidine results in decreased expression of HJV mRNA

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

15-hydroxyprostaglandin dehydrogenase

decreases expression

echimidine results in decreased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

histidine rich calcium binding protein

decreases expression

echimidine results in decreased expression of HRC mRNA

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

echimidine results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

indolethylamine N-methyltransferase

decreases expression

echimidine results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

kinesin family member 11

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 23

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

mal, T-cell differentiation protein

increases expression

echimidine results in increased expression of MAL mRNA

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

myoglobin

decreases expression

echimidine results in decreased expression of MB mRNA

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

O-6-methylguanine-DNA methyltransferase

increases expression

echimidine results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

increases expression

echimidine results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MYB proto-oncogene like 1

increases expression

echimidine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

myosin binding protein C3

decreases expression

echimidine results in decreased expression of MYBPC3 mRNA

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

myosin heavy chain 6

decreases expression

echimidine results in decreased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin, light chain 4

decreases expression

echimidine results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myozenin 2

decreases expression

echimidine results in decreased expression of MYOZ2 mRNA

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

poly (ADP-ribose) polymerase 1

multiple interactions

echimidine results in decreased expression of and results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of PKMYT1 mRNA

NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995

G

polo-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

polo-like kinase 3

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

polo-like kinase 4

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

phospholamban

decreases expression

echimidine results in decreased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

protein phosphatase, Mg2+/Mn2+ dependent, 1L

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PPM1L mRNA

NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2, regulatory subunit B', delta

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PPP2R5D mRNA

NCBI chr 9:14,270,364...14,300,396
Ensembl chr 9:14,268,745...14,300,400

G

protein phosphatase 2 regulatory subunit B', epsilon

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in increased expression of PPP2R5E mRNA

NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872

G

protein regulator of cytokinesis 1

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RAD21 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

solute carrier family 13 member 4

increases expression

echimidine results in increased expression of SLC13A4 mRNA

NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857

G

sarcolipin

decreases expression

echimidine results in decreased expression of SLN mRNA

NCBI chr 8:54,221,389...54,248,110
Ensembl chr 8:54,243,542...54,247,791

G

SH3 and cysteine rich domain 3

decreases expression

echimidine results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

STAG2 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of STAG2 mRNA

NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677

G

stanniocalcin 1

increases expression

echimidine results in increased expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

toll-like receptor 8

increases expression

echimidine results in increased expression of TLR8 mRNA

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

troponin C1, slow skeletal and cardiac type

decreases expression

echimidine results in decreased expression of TNNC1 mRNA

NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634

G

troponin T2, cardiac type

decreases expression

echimidine results in decreased expression of TNNT2 mRNA

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tripartite motif-containing 54

decreases expression

echimidine results in decreased expression of TRIM54 mRNA

NCBI chr 6:25,239,340...25,258,511
Ensembl chr 6:25,239,340...25,258,511

erucifoline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

H2A.X variant histone

increases expression

erucifoline results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

Heliotrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

heliotrine results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP-binding cassette, sub-family B member 1B

increases expression

heliotrine results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 6

decreases expression

heliotrine results in decreased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

acyl-CoA synthetase medium-chain family member 3

decreases expression

heliotrine results in decreased expression of ACSM3 mRNA

PMID:26100227 PMID:32419051

NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184

G

actin gamma 2, smooth muscle

decreases expression

heliotrine results in decreased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

actinin alpha 2

decreases expression

heliotrine results in decreased expression of ACTN2 mRNA

NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622

G

ADAM metallopeptidase domain 8

increases expression

heliotrine results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

adhesion G protein-coupled receptor E4

increases expression

heliotrine results in increased expression of ADGRE4 mRNA

NCBI chr 9:9,758,106...9,901,908
Ensembl chr 9:9,760,355...9,900,760

G

ALF transcription elongation factor 3

decreases expression

heliotrine results in decreased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

alanine--glyoxylate aminotransferase

decreases expression

heliotrine results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

aldehyde dehydrogenase 1 family, member A1

increases expression

heliotrine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 5 family, member A1

decreases expression

heliotrine results in decreased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

heliotrine results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

heliotrine results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

archaelysin family metallopeptidase 1

increases expression

heliotrine results in increased expression of AMZ1 mRNA

NCBI chr12:13,886,518...13,924,275
Ensembl chr12:13,891,123...13,909,783

G

ankyrin repeat domain 1

decreases expression

heliotrine results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

amphiregulin

increases expression

heliotrine results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ATPase H+ transporting V1 subunit D

increases expression

heliotrine results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

complement C3a receptor 1

increases expression

heliotrine results in increased expression of C3AR1 mRNA

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

caspase 3

multiple interactions

heliotrine results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

heliotrine results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

heliotrine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin G1

increases expression

heliotrine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin-dependent kinase inhibitor 1A

increases expression

heliotrine results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cytoskeleton associated protein 2

increases expression

heliotrine results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase, M-type

decreases expression

heliotrine results in decreased expression of CKM mRNA

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

creatine kinase, mitochondrial 2

decreases expression

heliotrine results in decreased expression of CKMT2 mRNA

NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430

G

C-type lectin domain family 4, member A1

increases expression

heliotrine results in increased expression of CLEC4A1 mRNA

NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008

G

C-type lectin domain family 4, member F

decreases expression

heliotrine results in decreased expression of CLEC4F mRNA

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

cytochrome c oxidase subunit 6A2

decreases expression

heliotrine results in decreased expression of COX6A2 mRNA

NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274

G

colony stimulating factor 1 receptor

decreases expression

heliotrine results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine rich protein 3

decreases expression

heliotrine results in decreased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance

CYP3A4 protein results in increased susceptibility to heliotrine

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases expression

heliotrine results in decreased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

heliotrine results in decreased expression of CYP4A22 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily f, polypeptide 18

decreases expression

heliotrine results in decreased expression of CYP4F3 mRNA

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

heliotrine results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

heliotrine results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

CYFIP related Rac1 interactor A

increases expression

heliotrine results in increased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

DNA damage-induced apoptosis suppressor

increases expression

heliotrine results in increased expression of DDIAS mRNA

NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462

G

dehydrogenase/reductase 9

increases expression

heliotrine results in increased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

deoxyribonuclease 1L3

decreases expression

heliotrine results in decreased expression of DNASE1L3 mRNA

NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317

G

dihydropyrimidine dehydrogenase

decreases expression

heliotrine results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

ectodysplasin A2 receptor

increases expression

heliotrine results in increased expression of EDA2R mRNA

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

eukaryotic translation elongation factor 1 alpha 2

decreases expression

heliotrine results in decreased expression of EEF1A2 mRNA

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

elastin microfibril interfacer 2

increases expression

heliotrine results in increased expression of EMILIN2 mRNA

NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352

G

epoxide hydrolase 1

increases expression

heliotrine results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

decreases expression

heliotrine results in decreased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

Fas cell surface death receptor

increases expression

heliotrine metabolite results in increased expression of FAS mRNA
heliotrine results in increased expression of FAS mRNA

PMID:30465738 PMID:32419051

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fc gamma receptor 3A

increases expression

heliotrine results in increased expression of FCGR3A mRNA

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

flavin containing dimethylaniline monoxygenase 3

decreases expression

heliotrine results in decreased expression of FMO3 mRNA

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

flavin containing dimethylaniline monoxygenase 4

decreases expression

heliotrine results in decreased expression of FMO4 mRNA

NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874

G

guanidinoacetate N-methyltransferase

decreases expression

heliotrine results in decreased expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778

G

GTP binding protein overexpressed in skeletal muscle

increases expression

heliotrine results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

glutaminase

increases expression

heliotrine results in increased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

glycine-N-acyltransferase

decreases expression

heliotrine results in decreased expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

G protein subunit alpha transducin 1

increases expression

heliotrine results in increased expression of GNAT1 mRNA

NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671

G

glypican 1

decreases expression

heliotrine results in decreased expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

gephyrin

decreases expression

heliotrine results in decreased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

G protein-coupled receptor, class C, group 5, member A

increases expression

heliotrine results in increased expression of GPRC5A mRNA

NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

heliotrine results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

G protein-coupled receptor kinase 3

increases expression

heliotrine results in increased expression of GRK3 mRNA

NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262

G

H2A.X variant histone

increases expression

heliotrine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hemojuvelin BMP co-receptor

decreases expression

heliotrine results in decreased expression of HJV mRNA

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

histamine N-methyltransferase

decreases expression

heliotrine results in decreased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

histidine rich calcium binding protein

decreases expression

heliotrine results in decreased expression of HRC mRNA

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

G

hydroxysteroid (17-beta) dehydrogenase 13

increases expression

heliotrine results in increased expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

interleukin 17 receptor D

increases expression

heliotrine results in increased expression of IL17RD mRNA

NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556

G

indolethylamine N-methyltransferase

decreases expression

heliotrine results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

interferon stimulated exonuclease gene 20

increases expression

heliotrine results in increased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit alpha L

increases expression

heliotrine results in increased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit beta 2

increases expression

heliotrine results in increased expression of ITGB2 mRNA

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

junctional adhesion molecule 3

increases expression

heliotrine results in increased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

kinetochore scaffold 1

increases expression

heliotrine results in increased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

MAF bZIP transcription factor F

increases expression

heliotrine results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mal, T-cell differentiation protein

increases expression

heliotrine results in increased expression of MAL mRNA

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

monoamine oxidase A

decreases expression

heliotrine results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases expression

heliotrine results in decreased expression of MAOB mRNA

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

microtubule associated serine/threonine kinase-like

increases expression

heliotrine results in increased expression of MASTL mRNA

NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353

G

myoglobin

decreases expression

heliotrine results in decreased expression of MB mRNA

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

O-6-methylguanine-DNA methyltransferase

increases expression

heliotrine results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

increases expression

heliotrine results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

increases expression

heliotrine results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

MOK protein kinase

increases expression

heliotrine results in increased expression of MOK mRNA

NCBI chr 6:129,823,794...129,854,669
Ensembl chr 6:129,823,795...129,854,700

G

MYB proto-oncogene like 1

increases expression

heliotrine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYB proto-oncogene like 2

increases expression

heliotrine results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

myosin binding protein C3

decreases expression

heliotrine results in decreased expression of MYBPC3 mRNA

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

myosin heavy chain 6

decreases expression

heliotrine results in decreased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin, light chain 4

decreases expression

heliotrine results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myomesin 1

decreases expression

heliotrine results in decreased expression of MYOM1 mRNA

NCBI chr 9:110,916,156...111,039,344
Ensembl chr 9:110,915,943...111,039,344

G

myozenin 2

decreases expression

heliotrine results in decreased expression of MYOZ2 mRNA

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

nebulin

decreases expression

heliotrine results in decreased expression of NEB mRNA

NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574

G

nicotinamide N-methyltransferase

decreases expression

heliotrine results in decreased expression of NNMT mRNA

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

neuronal cell adhesion molecule

increases expression

heliotrine results in increased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neuregulin 1

increases expression

heliotrine results in increased expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

poly (ADP-ribose) polymerase 1

decreases expression

heliotrine results in decreased expression of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phospholipase D family, member 4

increases expression

heliotrine results in increased expression of PLD4 mRNA

NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376

G

phospholamban

decreases expression

heliotrine results in decreased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

proline-serine-threonine phosphatase-interacting protein 2

increases expression

heliotrine results in increased expression of PSTPIP2 mRNA

NCBI chr18:71,310,387...71,396,752
Ensembl chr18:71,311,020...71,395,709

G

protein tyrosine phosphatase, receptor type, D

decreases expression

heliotrine results in decreased expression of PTPRD mRNA

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

Rap guanine nucleotide exchange factor 4

decreases expression

heliotrine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

heliotrine results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

SAM domain, SH3 domain and nuclear localization signals, 1

increases expression

heliotrine results in increased expression of SAMSN1 mRNA

NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900

G

sarcoglycan, beta

increases expression

heliotrine results in increased expression of SGCB mRNA

NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583

G

solute carrier family 10 member 1

decreases expression

heliotrine results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 13 member 4

increases expression

heliotrine results in increased expression of SLC13A4 mRNA

NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857

G

solute carrier family 22, member 25

decreases expression

heliotrine results in decreased expression of SLC22A9 mRNA

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 7

decreases expression

heliotrine results in decreased expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 38, member 7

increases expression

heliotrine results in increased expression of SLC38A7 mRNA

NCBI chr19:9,209,203...9,225,472
Ensembl chr19:9,209,257...9,225,454

G

solute carrier organic anion transporter family, member 2b1

decreases expression

heliotrine results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

sarcolipin

decreases expression

heliotrine results in decreased expression of SLN mRNA

NCBI chr 8:54,221,389...54,248,110
Ensembl chr 8:54,243,542...54,247,791

G

small muscle protein, X-linked

decreases expression

heliotrine results in decreased expression of SMPX mRNA

NCBI chr X:37,233,209...37,292,266
Ensembl chr X:37,234,294...37,276,708

G

sarcalumenin

decreases expression

heliotrine results in decreased expression of SRL mRNA

NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101

G

SH3 and cysteine rich domain 3

decreases expression

heliotrine results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

stanniocalcin 1

increases expression

heliotrine results in increased expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

STEAP4 metalloreductase

increases expression

heliotrine results in increased expression of STEAP4 mRNA

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

G

sulfotransferase family 1E member 1

decreases expression

heliotrine results in decreased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

decreases expression

heliotrine results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

teneurin transmembrane protein 1

decreases expression

heliotrine results in decreased expression of TENM1 mRNA

NCBI chr X:121,400,466...122,289,877
Ensembl chr X:121,403,649...122,290,207

G

teneurin transmembrane protein 2

decreases expression

heliotrine results in decreased expression of TENM2 mRNA

NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597

G

toll-like receptor 7

increases expression

heliotrine results in increased expression of TLR7 mRNA

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

toll-like receptor 8

increases expression

heliotrine results in increased expression of TLR8 mRNA

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

TNF receptor superfamily member 1B

increases expression

heliotrine results in increased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

troponin C1, slow skeletal and cardiac type

decreases expression

heliotrine results in decreased expression of TNNC1 mRNA

NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634

G

troponin T2, cardiac type

decreases expression

heliotrine results in decreased expression of TNNT2 mRNA

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

DNA topoisomerase II alpha

increases expression

heliotrine results in increased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

triggering receptor expressed on myeloid cells-like 4

increases expression

heliotrine results in increased expression of TREML4 mRNA

NCBI chr 9:12,718,968...12,743,879
Ensembl chr 9:12,721,815...12,743,253

G

tripartite motif-containing 54

decreases expression

heliotrine results in decreased expression of TRIM54 mRNA

NCBI chr 6:25,239,340...25,258,511
Ensembl chr 6:25,239,340...25,258,511

G

thymidylate synthetase

increases expression

heliotrine results in increased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

UDP glycosyltransferase family 3 member A1

decreases expression

heliotrine results in decreased expression of UGT3A1 mRNA

NCBI chr 2:58,327,058...58,350,186
Ensembl chr 2:58,334,603...58,350,186

G

vacuolar protein sorting 13 homolog B

decreases expression

heliotrine results in decreased expression of VPS13B mRNA

NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429

indicine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases response to substance

CYP3A4 protein results in increased metabolism of indicine
CYP3A4 protein results in increased susceptibility to indicine

PMID:32910235 PMID:33884520

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

H2A.X variant histone

increases expression

indicine analog results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

intermedine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

H2A.X variant histone

increases expression

intermedine analog results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

jacobine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

H2A.X variant histone

increases expression

jacobine analog results in increased expression of H2AX protein; jacobine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

ketorolac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 1

decreases expression

Ketorolac results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cysteinyl leukotriene receptor 1

multiple interactions

Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

DEAD-box helicase 3, X-linked

decreases expression

ketorolac decreases expression of DDX3X protein in oral epithelium

RGD

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

endothelial PAS domain protein 1

decreases expression

Ketorolac results in decreased expression of EPAS1 protein

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Fc epsilon receptor Ia

multiple interactions

Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Ketorolac results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

intercellular adhesion molecule 1

decreases expression

Ketorolac results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

[Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

myeloperoxidase

decreases activity

Ketorolac results in decreased activity of MPO

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA]

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

prostaglandin E receptor 4

multiple interactions

Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin-endoperoxide synthase 1

decreases expression
decreases activity

Ketorolac results in decreased expression of PTGS1 mRNA
Ketorolac results in decreased activity of PTGS1 protein

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions
decreases expression

Ketorolac results in increased expression of PTGS2 mRNA
Ketorolac inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]]
Ketorolac results in decreased expression of PTGS2 mRNA

PMID:17175104 PMID:17258197 PMID:19620882

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RT1 class Ia, locus A2

affects expression

Ketorolac affects the expression of HLA-E mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class I, locus CE16

affects expression

Ketorolac affects the expression of HLA-A mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

RT1 class Ib, locus M3, gene 1

affects expression

Ketorolac affects the expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

selectin E

decreases expression

Ketorolac results in decreased expression of SELE mRNA

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

signal transducer and activator of transcription 6

multiple interactions

Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

Lasiocarpine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

lasiocarpine results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP-binding cassette, sub-family B member 1B

increases expression

lasiocarpine results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

angiotensin I converting enzyme

decreases expression

lasiocarpine metabolite results in decreased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

ADAM metallopeptidase domain 8

increases expression

lasiocarpine results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

adhesion G protein-coupled receptor G1

increases expression

lasiocarpine results in increased expression of ADGRG1 mRNA

PMID:32234424 PMID:35690182

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

lasiocarpine results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

A-kinase anchoring protein 5

increases expression

lasiocarpine results in increased expression of AKAP5 mRNA

NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578

G

aldo-keto reductase family 1, member D1

decreases expression

lasiocarpine results in decreased expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

aldehyde dehydrogenase 1 family, member A1

increases expression

lasiocarpine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

alkaline phosphatase, intestinal

decreases expression

lasiocarpine results in decreased expression of ALPI mRNA

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

anaphase promoting complex subunit 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273

G

anaphase promoting complex subunit 11

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of ANAPC11 mRNA

NCBI chr10:105,875,209...105,886,307

G

anaphase promoting complex subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ANAPC2 mRNA

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

angiopoietin 1

decreases expression

lasiocarpine metabolite results in decreased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

arginase 1

decreases expression

lasiocarpine results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

AT-rich interaction domain 1A

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ARID1A mRNA

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ARID2 mRNA

NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512

G

ARF like GTPase 14

increases expression

lasiocarpine results in increased expression of ARL14 mRNA

PMID:32234424 PMID:35690182

NCBI chr 2:153,468,863...153,470,102
Ensembl chr 2:153,468,977...153,469,555

G

aspartate dehydrogenase domain containing

decreases expression

lasiocarpine results in decreased expression of ASPDH mRNA

NCBI chr 1:94,956,327...94,960,722
Ensembl chr 1:94,958,316...94,960,722

G

aspartic peptidase, retroviral-like 1

decreases expression

lasiocarpine results in decreased expression of ASPRV1 mRNA

NCBI chr 4:119,077,415...119,078,887
Ensembl chr 4:119,077,356...119,078,379

G

ATM serine/threonine kinase

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

aurora kinase A and ninein interacting protein

increases expression

lasiocarpine results in increased expression of AUNIP mRNA

NCBI chr 5:146,722,329...146,734,924
Ensembl chr 5:146,722,337...146,736,501

G

aurora kinase A

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

Axl receptor tyrosine kinase

decreases expression

lasiocarpine results in decreased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

BRISC and BRCA1 A complex member 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

BRCA1 associated RING domain 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

lasiocarpine results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

BLM RecQ like helicase

increases expression
multiple interactions

lasiocarpine results in increased expression of BLM mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BLM mRNA

PMID:32234424 PMID:33884520

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

bora, aurora kinase A activator

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BORA mRNA

NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322

G

BRCA1, DNA repair associated

increases expression
multiple interactions

lasiocarpine results in increased expression of BRCA1 mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRCA1 mRNA

PMID:32234424 PMID:33884520

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

increases expression
multiple interactions

lasiocarpine results in increased expression of BRCA2 mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRCA2 mRNA

PMID:32234424 PMID:33884520

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

bromodomain containing 7

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRD7 mRNA

NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494

G

BRCA1 interacting DNA helicase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

calpain 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CAPN1 mRNA

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

caspase 16

decreases expression

lasiocarpine results in decreased expression of CASP16P mRNA

NCBI chr10:12,586,009...12,592,023
Ensembl chr10:12,586,729...12,589,053
Ensembl chr10:12,586,729...12,589,053

G

coiled-coil domain containing 152

increases expression

lasiocarpine results in increased expression of CCDC152 mRNA

NCBI chr 2:52,507,987...52,532,880
Ensembl chr 2:52,507,981...52,532,826

G

cyclin B1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin E2

increases expression

lasiocarpine results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G1

increases expression

lasiocarpine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD83 molecule

increases expression

lasiocarpine results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

cell division cycle 16

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 20

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 23

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CDC23 mRNA

NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163

G

cell division cycle 25A

increases expression
multiple interactions

lasiocarpine results in increased expression of CDC25A mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25A mRNA

PMID:32234424 PMID:33884520

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25B

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

CDC42 binding protein kinase gamma

increases expression

lasiocarpine results in increased expression of CDC42BPG mRNA

NCBI chr 1:203,608,339...203,628,502
Ensembl chr 1:203,608,574...203,628,502

G

cell division cycle 45

increases expression

lasiocarpine results in increased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

increases expression

lasiocarpine results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle 7

increases expression
multiple interactions

lasiocarpine results in increased expression of CDC7 mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC7 mRNA

PMID:32234424 PMID:33884520

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cyclin-dependent kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

lasiocarpine results in increased expression of CDKN1A mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CDKN1A mRNA

PMID:32419051 PMID:33884520

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

chromatin licensing and DNA replication factor 1

increases expression

lasiocarpine results in increased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

carboxyl ester lipase

increases expression

lasiocarpine results in increased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

checkpoint kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

claudin 14

decreases expression

lasiocarpine results in decreased expression of CLDN14 mRNA

PMID:32234424 PMID:35690182

NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171

G

C-type lectin domain family 4, member F

decreases expression

lasiocarpine results in decreased expression of CLEC4F mRNA

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

claspin

increases expression
multiple interactions

lasiocarpine results in increased expression of CLSPN mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CLSPN mRNA

PMID:32234424 PMID:33884520

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

collagen type V alpha 2 chain

decreases expression

lasiocarpine results in decreased expression of COL5A2 mRNA

PMID:32234424 PMID:35690182

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

CDP-L-ribitol pyrophosphorylase A

decreases expression

lasiocarpine results in decreased expression of CRPPA mRNA

NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028

G

colony stimulating factor 1 receptor

decreases expression

lasiocarpine results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cytochrome b-245 alpha chain

decreases expression

lasiocarpine results in decreased expression of CYBA mRNA

PMID:32234424 PMID:35690182

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

lasiocarpine results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases expression

lasiocarpine results in decreased expression of CYP2A7 mRNA

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

lasiocarpine results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases response to substance
multiple interactions

CYP3A2 protein results in increased metabolism of lasiocarpine
CYP3A4 protein results in increased susceptibility to lasiocarpine
CYP3A4 protein results in increased metabolism of lasiocarpine
[CYP3A4 protein results in increased metabolism of lasiocarpine] which affects the expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ARID1A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ATM mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRD7 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC16 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDC7 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F3 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of HLTF mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MLH1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PPP2R5D mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD17 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SLC19A1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMC1A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of ANAPC11 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CAPN1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of E2F7 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of STAT1 mRNA; [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased phosphorylation of H2AX protein

PMID:31103741 PMID:32910235 PMID:33884520 PMID:35882637

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases metabolic processing

CYP3A23-3A1 protein results in increased metabolism of lasiocarpine

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

CYP3A5 protein results in increased metabolism of lasiocarpine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

lasiocarpine results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

CYFIP related Rac1 interactor A

increases expression

lasiocarpine results in increased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

DNA replication and sister chromatid cohesion 1

increases expression

lasiocarpine results in increased expression of DSCC1 mRNA

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

G

denticleless E3 ubiquitin protein ligase homolog

increases expression

lasiocarpine results in increased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

E2F transcription factor 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

lasiocarpine results in increased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 3

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 5

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 7

increases expression
multiple interactions

lasiocarpine results in increased expression of E2F7 mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of E2F7 mRNA

PMID:32234424 PMID:33884520

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

increases expression
multiple interactions

lasiocarpine results in increased expression of E2F8 mRNA
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of E2F8 mRNA

PMID:32234424 PMID:33884520

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

ectodysplasin A2 receptor

increases expression

lasiocarpine results in increased expression of EDA2R mRNA

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

ecto-NOX disulfide-thiol exchanger 1

decreases expression

lasiocarpine results in decreased expression of ENOX1 mRNA

PMID:32234424 PMID:35690182

NCBI chr15:52,517,833...53,079,752
Ensembl chr15:52,515,178...53,079,749

G

extra spindle pole bodies like 1, separase

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

exonuclease 1

increases expression

lasiocarpine results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

fatty acid binding protein 1

decreases expression

lasiocarpine results in decreased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

family with sequence similarity 151, member A

decreases expression

lasiocarpine results in decreased expression of FAM151A mRNA

NCBI chr 5:121,514,804...121,527,555
Ensembl chr 5:121,514,804...121,527,555

G

FA complementation group A

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCA mRNA

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

G

FA complementation group B

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group D2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group G

increases expression

lasiocarpine results in increased expression of FANCG mRNA

NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029

G

FA complementation group I

increases expression

lasiocarpine results in increased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

Fas cell surface death receptor

increases expression

lasiocarpine metabolite results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box protein 5

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

FOXF1 adjacent non-coding developmental regulatory RNA

increases expression

lasiocarpine results in increased expression of FENDRR mRNA

NCBI chr19:49,127,225...49,152,780
Ensembl chr19:49,121,214...49,153,240

G

fibroblast growth factor 13

decreases expression

lasiocarpine results in decreased expression of FGF13 mRNA

NCBI chr X:137,276,498...137,800,056
Ensembl chr X:137,276,511...137,800,391

G

fibroblast growth factor 2

decreases expression

lasiocarpine metabolite results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fragile histidine triad diadenosine triphosphatase

decreases expression

lasiocarpine results in decreased expression of FHIT mRNA

PMID:32234424 PMID:35690182

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

FIGNL1 interacting regulator of recombination and mitosis

increases expression

lasiocarpine results in increased expression of FIRRM mRNA

NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804

G

fibronectin 1

decreases expression

lasiocarpine metabolite results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FOS like 1, AP-1 transcription factor subunit

increases expression

lasiocarpine results in increased expression of FOSL1 mRNA

PMID:32234424 PMID:35690182

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

lasiocarpine results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth differentiation factor 15

increases expression

lasiocarpine results in increased expression of GDF15 mRNA

PMID:32234424 PMID:35690182

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycine N-methyltransferase

decreases expression

lasiocarpine results in decreased expression of GNMT mRNA

PMID:32234424 PMID:35690182

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glypican 6

decreases expression

lasiocarpine results in decreased expression of GPC6 mRNA

NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006

G

G protein-coupled receptor 161

increases expression

lasiocarpine results in increased expression of GPR161 mRNA

NCBI chr13:77,578,257...77,623,661
Ensembl chr13:77,577,739...77,619,613

G

glutamic--pyruvic transaminase

affects activity

lasiocarpine affects the activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

GRB2-related adaptor protein 2

increases expression

lasiocarpine results in increased expression of GRAP2 mRNA

NCBI chr 7:112,117,142...112,190,880
Ensembl chr 7:112,117,142...112,190,877

G

guanylate cyclase 2E

decreases expression

lasiocarpine results in decreased expression of GUCY2D mRNA

NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067

G

granzyme A

decreases expression

lasiocarpine results in decreased expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H2A.X variant histone

increases phosphorylation
multiple interactions
increases expression

lasiocarpine results in increased phosphorylation of H2AX protein
[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased phosphorylation of H2AX protein
lasiocarpine results in increased expression of H2AX protein

PMID:31103741 PMID:31154085 PMID:31289892

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

helicase, lymphoid specific

increases expression

lasiocarpine results in increased expression of HELLS mRNA

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

hedgehog acyltransferase

decreases expression

lasiocarpine results in decreased expression of HHAT mRNA

NCBI chr13:104,024,507...104,283,580
Ensembl chr13:104,010,916...104,282,893

G

hemojuvelin BMP co-receptor

decreases expression

lasiocarpine results in decreased expression of HJV mRNA

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

helicase-like transcription factor

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of HLTF mRNA

NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327

G

hemicentin 1

decreases expression

lasiocarpine results in decreased expression of HMCN1 mRNA

NCBI chr13:62,615,461...63,084,524
Ensembl chr13:62,615,461...63,084,524

G

high mobility group nucleosome binding domain 5

increases expression

lasiocarpine results in increased expression of HMGN5 mRNA

NCBI chr X:74,085,871...74,094,488
Ensembl chr X:74,085,875...74,094,441
Ensembl chr 1:74,085,875...74,094,441

G

15-hydroxyprostaglandin dehydrogenase

decreases expression

lasiocarpine results in decreased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

heparan sulfate 6-O-sulfotransferase 3

decreases expression

lasiocarpine results in decreased expression of HS6ST3 mRNA

PMID:32234424 PMID:35690182

NCBI chr15:96,281,502...97,000,804
Ensembl chr15:96,281,646...97,000,462

G

hydroxysteroid (17-beta) dehydrogenase 13

increases expression

lasiocarpine results in increased expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

immunoglobulin superfamily, member 23

decreases expression

lasiocarpine results in decreased expression of IGSF23 mRNA

NCBI chr 1:79,591,059...79,606,323
Ensembl chr 1:79,592,088...79,610,438

G

interleukin 11

increases expression

lasiocarpine metabolite results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 17 receptor D

increases expression

lasiocarpine results in increased expression of IL17RD mRNA

NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556

G

interleukin 1 beta

increases expression

lasiocarpine metabolite results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

inner mitochondrial membrane peptidase subunit 2

decreases expression

lasiocarpine results in decreased expression of IMMP2L mRNA

PMID:32234424 PMID:35690182

NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840

G

inositol polyphosphate-5-phosphatase D

increases expression

lasiocarpine results in increased expression of INPP5D mRNA

NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746

G

integrin subunit alpha 8

decreases expression

lasiocarpine results in decreased expression of ITGA8 mRNA

NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510

G

junctional adhesion molecule 3

increases expression

lasiocarpine results in increased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

lasiocarpine results in decreased expression of KCNMA1 mRNA

PMID:32234424 PMID:35690182

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

KIAA0319 homolog

increases expression

lasiocarpine results in increased expression of KIAA0319 mRNA

NCBI chr17:40,162,512...40,226,666
Ensembl chr17:40,165,084...40,225,653

G

kinesin family member 11

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 23

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which affects the expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kynurenine 3-monooxygenase

decreases expression

lasiocarpine results in decreased expression of KMO mRNA

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

lysosomal-associated membrane protein 3

increases expression

lasiocarpine results in increased expression of LAMP3 mRNA

NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784

G

LIF, interleukin 6 family cytokine

increases expression

lasiocarpine results in increased expression of LIF mRNA

PMID:32234424 PMID:35690182

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

leucine rich repeat and Ig domain containing 4

decreases expression

lasiocarpine results in decreased expression of LINGO4 mRNA

NCBI chr 2:182,035,522...182,040,787
Ensembl chr 2:182,014,326...182,040,787

G

leucine rich melanocyte differentiation associated

decreases expression

lasiocarpine results in decreased expression of LRMDA mRNA

PMID:32234424 PMID:35690182

NCBI chr15:1,223,098...2,284,764
Ensembl chr15:1,225,710...2,284,749

G

leucine rich repeat containing 39

decreases expression

lasiocarpine results in decreased expression of LRRC39 mRNA

NCBI chr 2:204,516,122...204,535,463
Ensembl chr 2:204,516,123...204,535,463

G

leucine zipper tumor suppressor 1

increases expression

lasiocarpine results in increased expression of LZTS1 mRNA

NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203

G

mab-21 like 4

decreases expression

lasiocarpine results in decreased expression of MAB21L4 mRNA

NCBI chr 9:93,690,455...93,701,267
Ensembl chr 9:93,690,999...93,700,506

G

mono-ADP ribosylhydrolase 2

decreases expression

lasiocarpine results in decreased expression of MACROD2 mRNA

NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492

G

mannose binding lectin 2

decreases expression

lasiocarpine results in decreased expression of MBL2 mRNA

NCBI chr 1:228,016,439...228,024,736

G

minichromosome maintenance 10 replication initiation factor

increases expression

lasiocarpine results in increased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

O-6-methylguanine-DNA methyltransferase

increases expression

lasiocarpine results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

mutL homolog 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MLH1 mRNA

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

meiotic nuclear divisions 1

increases expression

lasiocarpine results in increased expression of MND1 mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

MAGUK p55 scaffold protein 2

increases expression

lasiocarpine results in increased expression of MPP2 mRNA

NCBI chr10:87,011,434...87,043,883
Ensembl chr10:87,011,434...87,043,896

G

MRE11 homolog, double strand break repair nuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MRE11 mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mutS homolog 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

mucin 13, cell surface associated

increases expression

lasiocarpine results in increased expression of MUC13 mRNA

NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727

G

MYB proto-oncogene like 1

increases expression

lasiocarpine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYB proto-oncogene like 2

increases expression

lasiocarpine results in increased expression of MYBL2 mRNA

PMID:32234424 PMID:32419051

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

myosin X

increases expression

lasiocarpine results in increased expression of MYO10 mRNA

NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030

G

N-acetylated alpha-linked acidic dipeptidase-like 2

decreases expression

lasiocarpine results in decreased expression of NAALADL2 mRNA

PMID:32234424 PMID:35690182

NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689

G

neutrophil cytosolic factor 2

increases expression

lasiocarpine results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

nectin cell adhesion molecule 4

increases expression

lasiocarpine results in increased expression of NECTIN4 mRNA

PMID:32234424 PMID:35690182

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

ninein-like

decreases expression

lasiocarpine results in decreased expression of NINL mRNA

PMID:32234424 PMID:35690182

NCBI chr 3:139,748,353...139,814,683
Ensembl chr 3:139,748,355...139,814,622

G

neuronal PAS domain protein 3

decreases expression

lasiocarpine results in decreased expression of NPAS3 mRNA

NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884

G

natriuretic peptide receptor 1

decreases expression

lasiocarpine metabolite results in decreased expression of NPR1 mRNA

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

lasiocarpine results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group I, member 3

decreases expression

lasiocarpine results in decreased expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

neuronal cell adhesion molecule

increases expression

lasiocarpine results in increased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neurogranin

increases expression

lasiocarpine results in increased expression of NRGN mRNA

NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516

G

neurotensin

decreases expression

lasiocarpine results in decreased expression of NTS mRNA

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nuclear protein 1, transcriptional regulator

increases expression

lasiocarpine results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

origin recognition complex, subunit 1

increases expression

lasiocarpine results in increased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

p21 (RAC1) activated kinase 5

decreases expression

lasiocarpine results in decreased expression of PAK5 mRNA

PMID:32234424 PMID:35690182

NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930

G

platelet and endothelial cell adhesion molecule 1

decreases expression

lasiocarpine metabolite results in decreased expression of PECAM1 mRNA

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

decreases expression

lasiocarpine results in decreased expression of PFKFB1 mRNA

PMID:32234424 PMID:35690182

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182

G

peptidoglycan recognition protein 2

decreases expression

lasiocarpine results in decreased expression of PGLYRP2 mRNA

NCBI chr 7:11,418,674...11,432,162
Ensembl chr 7:11,418,880...11,427,773

G

PHD finger protein 10

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PHF10 mRNA

NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038

G

pyruvate kinase L/R

decreases expression

lasiocarpine results in decreased expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

plasminogen

decreases expression

lasiocarpine results in decreased expression of PLG mRNA

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

polo-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

polo-like kinase 3

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

polo-like kinase 4

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

phospholipid transfer protein

decreases expression

lasiocarpine results in decreased expression of PLTP mRNA

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

DNA polymerase epsilon 2, accessory subunit

increases expression

lasiocarpine results in increased expression of POLE2 mRNA

NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305

G

DNA polymerase theta

increases expression

lasiocarpine results in increased expression of POLQ mRNA

NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878

G

POU class 2 homeobox 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of POU2F1 mRNA

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

lasiocarpine results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

protein phosphatase 2, regulatory subunit B', delta

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PPP2R5D mRNA

NCBI chr 9:14,270,364...14,300,396
Ensembl chr 9:14,268,745...14,300,400

G

protein regulator of cytokinesis 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

lasiocarpine results in decreased expression of PARK2 mRNA; lasiocarpine results in decreased expression of PRKN mRNA

PMID:32234424 PMID:35690182

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

PSMC3 interacting protein

increases expression

lasiocarpine results in increased expression of PSMC3IP mRNA

NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423

G

prostaglandin I2 synthase

decreases expression
decreases expression

lasiocarpine metabolite results in decreased expression of PTGIS mRNA; lasiocarpine metabolite results in decreased expression of PTGIS protein
[Lasiocarpine cotreated with liver homogenate supernatant] decreases expression of PTGIS mRNA in vascular endothelial cells

CTD
RGD

PMID:30465738 PMID:30465738

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 2

increases expression

lasiocarpine metabolite results in increased expression of PTGS2 mRNA; lasiocarpine metabolite results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RAD1 checkpoint DNA exonuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD1 mRNA

NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689

G

RAD17 checkpoint clamp loader component

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD17 mRNA

NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072

G

RAD21 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RAD51 paralog B

decreases expression

lasiocarpine results in decreased expression of RAD51B mRNA

NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979

G

RB binding protein 8, endonuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RB transcriptional corepressor like 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

retinol dehydrogenase 16

decreases expression

lasiocarpine results in decreased expression of RDH16 mRNA

NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124

G

replication factor C subunit 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC1 mRNA

NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370

G

replication factor C subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

replication factor C subunit 3

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 4

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC4 mRNA

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

replication factor C subunit 5

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC5 mRNA

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

regulator of G-protein signaling 16

increases expression

lasiocarpine results in increased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

rhomboid like 3

increases expression

lasiocarpine results in increased expression of RHBDL3 mRNA

NCBI chr10:65,299,250...65,354,099
Ensembl chr10:65,299,194...65,354,099

G

Rh family B glycoprotein

decreases expression

lasiocarpine results in decreased expression of RHBG mRNA

NCBI chr 2:173,704,852...173,717,380
Ensembl chr 2:173,704,562...173,717,321

G

replication protein A1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RPA1 mRNA

NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

lasiocarpine results in increased expression of RRAD mRNA

PMID:32234424 PMID:35690182

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

S100 calcium binding protein A2

increases expression

lasiocarpine results in increased expression of S100A2 mRNA

NCBI chr 2:176,077,081...176,078,325

G

SH3 domain binding kinase 1

increases expression

lasiocarpine results in increased expression of SBK1 mRNA

NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885

G

sidekick cell adhesion molecule 1

decreases expression

lasiocarpine results in decreased expression of SDK1 mRNA

PMID:32234424 PMID:35690182

NCBI chr12:12,378,074...13,363,934
Ensembl chr12:12,380,524...13,363,976

G

serpin family B member 2

increases expression

lasiocarpine results in increased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

stratifin

increases expression

lasiocarpine results in increased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

SH3 domain containing ring finger 3

decreases expression

lasiocarpine results in decreased expression of SH3RF3 mRNA

NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257

G

solute carrier family 19 member 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SLC19A1 mRNA

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 27 member 5

decreases expression

lasiocarpine results in decreased expression of SLC27A5 mRNA

NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMARCC1 mRNA

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

structural maintenance of chromosomes 1A

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMC1A mRNA

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

G

structural maintenance of chromosomes 3

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

sphingomyelin phosphodiesterase 3

decreases expression

lasiocarpine results in decreased expression of SMPD3 mRNA

PMID:32234424 PMID:35690182

NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749

G

SPARC like 1

decreases expression

lasiocarpine results in decreased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

decreases expression

lasiocarpine results in decreased expression of SPOCK3 mRNA

PMID:32234424 PMID:35690182

NCBI chr16:26,382,895...26,815,943
Ensembl chr16:26,383,383...26,815,205

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases expression

lasiocarpine results in increased expression of SRC mRNA

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

SH3 and cysteine rich domain 3

decreases expression

lasiocarpine results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

STAG2 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of STAG2 mRNA

NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677

G

signal transducer and activator of transcription 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

stanniocalcin 1

increases expression

lasiocarpine results in increased expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

serine threonine kinase 31

decreases expression

lasiocarpine results in decreased expression of STK31 mRNA

NCBI chr 4:78,370,691...78,467,599
Ensembl chr 4:78,370,649...78,466,240

G

succinate receptor 1

decreases expression

lasiocarpine results in decreased expression of SUCNR1 mRNA

NCBI chr 2:144,219,066...144,230,568
Ensembl chr 2:144,219,122...144,230,034

G

succinylCoA:glutarate-CoA transferase

decreases expression

lasiocarpine results in decreased expression of SUGCT mRNA

PMID:32234424 PMID:35690182

NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376

G

transcription factor 19

increases expression

lasiocarpine results in increased expression of TCF19 mRNA

NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271

G

TEK receptor tyrosine kinase

decreases expression

lasiocarpine metabolite results in decreased expression of TEK mRNA

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

testis expressed 15, meiosis and synapsis associated

increases expression

lasiocarpine results in increased expression of TEX15 mRNA

NCBI chr16:58,598,991...58,659,005
Ensembl chr16:58,598,989...58,658,467

G

tissue factor pathway inhibitor

decreases expression

lasiocarpine metabolite results in decreased expression of TFPI mRNA

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

transforming growth factor, beta 1

decreases expression

lasiocarpine metabolite results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thyroid hormone responsive

decreases expression

lasiocarpine results in decreased expression of THRSP mRNA

PMID:32234424 PMID:35690182

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

tousled-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

toll-like receptor 8

increases expression

lasiocarpine results in increased expression of TLR8 mRNA

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

transmembrane protein 266

decreases expression

lasiocarpine results in decreased expression of TMEM266 mRNA

NCBI chr 8:55,707,122...55,820,692
Ensembl chr 8:55,707,122...55,820,692

G

thymosin beta 15B2

increases expression

lasiocarpine results in increased expression of TMSB15A mRNA

NCBI chr X:100,298,705...100,300,820
Ensembl chr X:100,298,514...100,300,886

G

TNF superfamily member 10

decreases expression

lasiocarpine metabolite results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

DNA topoisomerase II alpha

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II binding protein 1

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOPBP1 mRNA

NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674

G

tumor protein p73

increases expression

lasiocarpine results in increased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

thyroid hormone receptor interactor 13

increases expression

lasiocarpine results in increased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

transient receptor potential cation channel, subfamily A, member 1

increases expression

lasiocarpine results in increased expression of TRPA1 mRNA

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

tetraspanin 15

increases expression

lasiocarpine results in increased expression of TSPAN15 mRNA

NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930

G

thymidine phosphorylase

increases expression

lasiocarpine metabolite results in increased expression of TYMP mRNA

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

tyrosinase-related protein 1

decreases expression

lasiocarpine results in decreased expression of TYRP1 mRNA

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

lasiocarpine results in increased expression of UGT2B17 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

ubiquitin-like with PHD and ring finger domains 1

increases expression

lasiocarpine results in increased expression of UHRF1 mRNA

NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631

G

integral membrane transport protein UST5r

decreases expression

lasiocarpine results in decreased expression of SLC22A25 mRNA

NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:205,211,034...205,286,718

G

von Willebrand factor

decreases expression

lasiocarpine metabolite results in decreased expression of VWF mRNA

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

WEE1 G2 checkpoint kinase

multiple interactions

[CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

Wnt family member 7B

increases expression

lasiocarpine results in increased expression of WNT7B mRNA

PMID:32234424 PMID:35690182

NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581

G

WW domain-containing oxidoreductase

decreases expression

lasiocarpine results in decreased expression of WWOX mRNA

PMID:32234424 PMID:35690182

NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391

licofelone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

increases expression

licofelone results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

otosenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

H2A.X variant histone

increases expression

otosenine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

riddelliine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA

PMID:18047722 PMID:18047727

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 9

decreases expression

riddelliine results in decreased expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 3

increases expression

riddelliine results in increased expression of ABCC3 mRNA

PMID:18047722 PMID:18047727

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 8

decreases expression

riddelliine results in decreased expression of ABCC8 mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

ATP binding cassette subfamily C member 9

decreases expression

riddelliine results in decreased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

adrenomedullin

decreases expression

riddelliine results in decreased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

aryl hydrocarbon receptor

increases expression

riddelliine results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

anaphase promoting complex subunit 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273

G

AT-rich interaction domain 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA

NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512

G

ATPase 13A5

decreases expression

riddelliine results in decreased expression of ATP13A5 mRNA

NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789

G

aurora kinase A

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

BRISC and BRCA1 A complex member 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

BRCA1 associated RING domain 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BLM RecQ like helicase

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

bora, aurora kinase A activator

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA

NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322

G

BRCA1, DNA repair associated

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

BRCA1 interacting DNA helicase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

cyclin B1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cell division cycle 20

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 23

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA

NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163

G

cell division cycle 25A

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25B

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cyclin-dependent kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxylesterase 2H

increases expression

riddelliine results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

checkpoint kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

claspin

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

C-X-C motif chemokine receptor 1

increases expression

riddelliine results in increased expression of CXCR1 mRNA

NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

riddelliine results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

riddelliine results in decreased expression of CYP2C mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 12

increases expression

riddelliine results in increased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily c, polypeptide 13

decreases expression

riddelliine results in decreased expression of CYP2C13 mRNA

NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191

G

cytochrome P450, family 2, subfamily c, polypeptide 22

decreases expression

riddelliine results in decreased expression of CYP2C22 mRNA

NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

riddelliine results in increased expression of CYP2E1 mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 18

decreases expression

riddelliine results in decreased expression of CYP3A18 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
increases response to substance
multiple interactions
increases metabolic processing

riddelliine results in decreased expression of CYP3A2 mRNA
CYP3A4 protein results in increased susceptibility to riddelliine
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA

PMID:18047727 PMID:32910235 PMID:33884520

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

riddelliine results in increased expression of CYP3A9 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 8

decreases expression

riddelliine results in decreased expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

E2F transcription factor 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 5

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 8

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

early growth response 1

increases expression

riddelliine results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

riddelliine results in decreased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

extra spindle pole bodies like 1, separase

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

F11 receptor

decreases expression

riddelliine results in decreased expression of F11R mRNA

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor III, tissue factor

decreases expression

riddelliine results in decreased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

coagulation factor VII

increases expression

riddelliine results in increased expression of F7 mRNA

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

FA complementation group A

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

G

FA complementation group B

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group C

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA

NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376

G

FA complementation group D2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

Fas cell surface death receptor

increases expression

riddelliine results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box protein 5

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

flavin containing dimethylaniline monoxygenase 5

increases expression

riddelliine results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutathione S-transferase alpha 3

increases expression

riddelliine results in increased expression of GSTA3 mRNA

PMID:18047722 PMID:18047727

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase mu 1

decreases expression

riddelliine results in decreased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases expression

riddelliine results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

H2A.X variant histone

increases phosphorylation
increases expression

riddelliine results in increased phosphorylation of H2AX protein
riddelliine results in increased expression of H2AX protein

PMID:31154085 PMID:31289892

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hepatocyte growth factor

increases expression

riddelliine results in increased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

insulin-like growth factor binding protein 1

increases expression

riddelliine results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 2

increases expression

riddelliine results in increased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

interleukin 11

increases expression

riddelliine results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 15

increases expression

riddelliine results in increased expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 7

decreases expression

riddelliine results in decreased expression of IL7 mRNA

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

indolethylamine N-methyltransferase

decreases expression

riddelliine results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

integrin subunit alpha 4

increases expression

riddelliine results in increased expression of ITGA4 mRNA

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 6

decreases expression

riddelliine results in decreased expression of ITGA6 mRNA

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

kinase insert domain receptor

multiple interactions
increases expression

riddelliine results in increased phosphorylation of and results in increased activity of KDR protein
riddelliine results in increased expression of KDR protein

PMID:12460743 PMID:15384251

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 11

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 23

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

KRAS proto-oncogene, GTPase

increases mutagenesis

riddelliine results in increased mutagenesis of KRAS gene

PMID:13678655 PMID:20737008

NCBI chr 4:178,185,418...178,218,484

G

leptin receptor

increases expression

riddelliine results in increased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

mediator of DNA damage checkpoint 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

matrix metallopeptidase 7

decreases expression

riddelliine results in decreased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

MRE11 homolog, double strand break repair nuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mutS homolog 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

metallothionein 1

increases expression

riddelliine results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

decreases expression

riddelliine results in decreased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

nibrin

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA

NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150

G

NAD(P)H quinone dehydrogenase 1

increases expression

riddelliine results in increased expression of NQO1 mRNA

PMID:18047722 PMID:18047727

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

polybromo 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA

NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780

G

PHD finger protein 10

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA

NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA

NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995

G

polo-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

polo-like kinase 3

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

polo-like kinase 4

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

POU class 2 homeobox 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

peroxisome proliferator-activated receptor gamma

decreases expression

riddelliine results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1L

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA

NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A beta

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA

NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485

G

protein phosphatase 2, regulatory subunit B, alpha

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA

NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924

G

protein regulator of cytokinesis 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

protein kinase C, alpha

increases expression

riddelliine results in increased expression of PRKCA mRNA

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, zeta

increases expression

riddelliine results in increased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RAD1 checkpoint DNA exonuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA

NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689

G

RAD21 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RB binding protein 8, endonuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RB transcriptional corepressor like 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

renin

increases expression

riddelliine results in increased expression of REN mRNA

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

replication factor C subunit 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA

NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370

G

replication factor C subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

replication factor C subunit 3

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 4

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

replication factor C subunit 5

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

replication protein A1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA

NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949

G

sphingosine-1-phosphate receptor 2

decreases expression

riddelliine results in decreased expression of S1PR2 mRNA

NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574

G

solute carrier family 13 member 5

decreases expression

riddelliine results in decreased expression of SLC13A5 mRNA

NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945

G

solute carrier family 16, member 4

decreases expression

riddelliine results in decreased expression of SLC16A4 mRNA

NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117

G

solute carrier family 22 member 6

decreases expression

riddelliine results in decreased expression of SLC22A6 mRNA

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases expression

riddelliine results in decreased expression of SLC22A8 mRNA

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 25 member 21

increases expression

riddelliine results in increased expression of SLC25A21 mRNA

NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680

G

solute carrier family 25, member 30

decreases expression

riddelliine results in decreased expression of SLC25A30 mRNA

NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613

G

solute carrier family 7 member 5

increases expression

riddelliine results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA

NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

structural maintenance of chromosomes 3

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases expression

riddelliine results in increased expression of SRC mRNA

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

STAG2 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA

NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677

G

signal transducer and activator of transcription 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

sulfotransferase family 1C member 3

decreases expression

riddelliine results in decreased expression of SULT1C1 mRNA

NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030

G

transforming growth factor alpha

decreases expression

riddelliine results in decreased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

tousled-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

tumor necrosis factor

decreases expression

riddelliine results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

increases expression

riddelliine results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

DNA topoisomerase II alpha

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II binding protein 1

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA

NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674

G

tumor protein p53

increases expression
increases mutagenesis

riddelliine results in increased expression of TP53 protein
riddelliine results in increased mutagenesis of TRP53 gene

PMID:12460743 PMID:13678655 PMID:20737008

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

WEE1 G2 checkpoint kinase

multiple interactions

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

senecionine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 3

decreases expression

senecionine results in decreased expression of ABCA3 protein

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

decreases expression

senecionine results in decreased expression of ABCB11 mRNA

PMID:26100227 PMID:31606820

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

decreases expression

senecionine results in decreased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

senecionine results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

decreases expression

senecionine results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

increases expression

senecionine results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases expression

senecionine results in decreased expression of ABCC2 mRNA

PMID:26100227 PMID:31606820

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
decreases expression

senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA

PMID:24641316 PMID:26100227 PMID:31606820

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

decreases expression

senecionine results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 6

decreases expression

senecionine results in decreased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

abhydrolase domain containing 11

increases expression

senecionine results in increased expression of ABHD11 protein

NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398

G

ankyrin repeat and BTB domain containing 2

increases expression

senecionine results in increased expression of ABTB2 protein

NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548

G

acetyl-CoA acyltransferase 1A

increases expression

senecionine results in increased expression of ACAA1A protein

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

senecionine results in increased expression of ACAA1B protein

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

acyl-CoA thioesterase 13

increases expression

senecionine results in increased expression of ACOT13 protein

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

G

acyl-CoA thioesterase 2

increases expression

senecionine results in increased expression of ACOT2 protein

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 3

increases expression

senecionine results in increased expression of ACOT3 protein

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA thioesterase 4

increases expression

senecionine results in increased expression of ACOT4 protein

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA synthetase long-chain family member 3

decreases expression

senecionine results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase long-chain family member 4

decreases expression

senecionine results in decreased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase medium-chain family member 3

decreases expression

senecionine results in decreased expression of ACSM3 mRNA

NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184

G

acyl-CoA synthetase short-chain family member 3

increases expression

senecionine results in increased expression of ACSS3 protein

NCBI chr 7:42,241,261...42,450,209
Ensembl chr 7:42,242,652...42,450,230

G

actin gamma 2, smooth muscle

decreases expression

senecionine results in decreased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

ADAM metallopeptidase domain 8

increases expression

senecionine results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases expression

senecionine results in increased expression of ADH1 protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

ALF transcription elongation factor 3

decreases expression

senecionine results in decreased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

alanine--glyoxylate aminotransferase

decreases expression

senecionine results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

allograft inflammatory factor 1

decreases expression

senecionine results in decreased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

A-kinase anchoring protein 12

increases expression

senecionine results in increased expression of AKAP12 protein

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldehyde dehydrogenase 1 family, member A1

increases expression

senecionine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

increases expression

senecionine results in increased expression of ALDH1B1 protein

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 6 family, member A1

increases expression

senecionine results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

senecionine results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

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anaphase promoting complex subunit 2

increases expression

senecionine results in increased expression of ANAPC2 protein

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

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ankyrin repeat domain 1

decreases expression

senecionine results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

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annexin A1

increases expression

senecionine results in increased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

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amyloid P component, serum

decreases expression

senecionine results in decreased expression of APCS protein

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

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apolipoprotein B

decreases expression

senecionine results in decreased expression of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

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apolipoprotein C1

decreases expression

senecionine results in decreased expression of APOC1 protein

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

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apolipoprotein H

decreases expression

senecionine results in decreased expression of APOH protein

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

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apolipoprotein M

decreases expression

senecionine results in decreased expression of APOM protein

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

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aquaporin 4

decreases expression

senecionine results in decreased expression of AQP4 protein

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

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aquaporin 8

increases expression

senecionine results in increased expression of AQP8 protein

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

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amphiregulin

increases expression

senecionine results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

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Rho GTPase activating protein 11A

increases expression

senecionine results in increased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

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ARL6 interacting reticulophagy regulator 1

decreases expression

senecionine results in decreased expression of ARL6IP1 protein

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

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ARF like GTPase 6 interacting protein 4

decreases expression

senecionine results in decreased expression of ARL6IP4 protein

NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799

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ATPase family, AAA domain containing 2

increases expression

senecionine results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

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activating transcription factor 3

increases expression

senecionine results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

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ATPase cation transporting 13A2

decreases expression

senecionine results in decreased expression of ATP13A2 protein

NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139

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ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

senecionine results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

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ATP synthase inhibitory factor subunit 1

decreases expression

senecionine results in decreased expression of ATP5IF1 protein

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

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ATPase H+ transporting V1 subunit H

increases expression

senecionine results in increased expression of ATP6V1H protein

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

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ATP synthase mitochondrial F1 complex assembly factor 2

increases expression

senecionine results in increased expression of ATPAF2 protein

NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026

G

axin 2

decreases expression

senecionine results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

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Beta-1,3-galactosyltransferase 1

decreases expression

senecionine results in decreased expression of B3GALT1 protein

NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313

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bile acid CoA:amino acid N-acyltransferase

decreases expression

senecionine results in decreased expression of BAAT mRNA

PMID:24641316 PMID:26100227

NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685

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Bcl2-like 1

decreases expression

senecionine results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

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BCL3, transcription coactivator

increases expression

senecionine results in increased expression of BCL3 protein

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

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BCL2 interacting protein 3

decreases expression

senecionine results in decreased expression of BNIP3 protein

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

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biorientation of chromosomes in cell division 1-like 1

decreases expression

senecionine results in decreased expression of BOD1L protein

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

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bisphosphoglycerate mutase

increases expression

senecionine results in increased expression of BPGM protein

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

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betacellulin

increases expression

senecionine results in increased expression of BTC protein

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

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complement C3

decreases expression

senecionine results in decreased expression of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

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complement C3a receptor 1

increases expression

senecionine results in increased expression of C3AR1 mRNA

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

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complement C4B

decreases expression

senecionine results in decreased expression of C4B protein

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

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complement C5

decreases expression

senecionine results in decreased expression of C5 protein

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

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