CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: azadirachtin
Accession: CHEBI:38473
browse the term
Definition: A family of terpenoids isolated from the neem tree (Azadirachta indica).
Synonyms: related_synonym: azadirachtins
xref: PMID:16619609; PMID:24357500
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Acp5
acid phosphatase 5, tartrate resistant
decreases expression multiple interactions
ISO
azadirachtin results in decreased expression of ACP5 mRNA azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
CTD
PMID:31225646
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
azadirachtin results in increased expression of APAF1 protein
CTD
PMID:20429769
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
azadirachtin results in increased expression of BAD mRNA
CTD
PMID:20429769
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
azadirachtin results in increased expression of BAX mRNA
CTD
PMID:20429769
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein
CTD
PMID:20429769
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
azadirachtin results in decreased expression of BCL2L1 mRNA
CTD
PMID:20429769
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bglap
bone gamma-carboxyglutamate protein
multiple interactions
ISO
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein]
CTD
PMID:31225646
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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Bid
BH3 interacting domain death agonist
increases expression
ISO
azadirachtin results in increased expression of BID mRNA
CTD
PMID:20429769
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
azadirachtin results in decreased expression of BIRC5 protein
CTD
PMID:20429769
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmp2
bone morphogenetic protein 2
increases expression
ISO
azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein
CTD
PMID:31225646
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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Casp3
caspase 3
increases expression
ISO
azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein
CTD
PMID:20429769
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases expression
ISO
azadirachtin results in increased expression of CASP6 protein
CTD
PMID:20429769
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp8
caspase 8
increases expression
ISO
azadirachtin results in increased expression of CASP8 protein
CTD
PMID:20429769
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases expression
ISO
azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein
CTD
PMID:20429769
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
decreases expression
ISO
azadirachtin results in decreased expression of CCND1 mRNA
CTD
PMID:20429769
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein
CTD
PMID:20429769
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cycs
cytochrome c, somatic
increases expression affects localization
ISO
azadirachtin results in increased expression of CYCS mRNA azadirachtin affects the localization of CYCS protein
CTD
PMID:20429769
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Esr1
estrogen receptor 1
increases expression affects binding multiple interactions
ISO
azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein azadirachtin binds to ESR1 protein 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
CTD
PMID:31225646
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions increases expression affects binding
ISO
azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA] azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein azadirachtin binds to ESR2 protein
CTD
PMID:31225646
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
decreases expression
ISO
azadirachtin results in decreased expression of IKBKB protein
CTD
PMID:20429769
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
azadirachtin results in increased phosphorylation of MAPK1 protein
CTD
PMID:31225646
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
azadirachtin results in increased phosphorylation of MAPK3 protein
CTD
PMID:31225646
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
azadirachtin results in decreased expression of NFKB1 protein
CTD
PMID:20429769
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
decreases expression
ISO
azadirachtin results in decreased expression of NFKBIA protein modified form
CTD
PMID:20429769
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein
CTD
PMID:20429769
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
azadirachtin results in decreased expression of RELA protein
CTD
PMID:20429769
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Runx2
RUNX family transcription factor 2
increases expression multiple interactions
ISO
azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
CTD
PMID:31225646
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Smad1
SMAD family member 1
increases expression
ISO
azadirachtin results in increased expression of SMAD1 protein modified form
CTD
PMID:31225646
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Tnf
tumor necrosis factor
decreases expression
ISO
azadirachtin results in decreased expression of TNF mRNA
CTD
PMID:31225646
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf11a
TNF receptor superfamily member 11A
multiple interactions decreases expression
ISO
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA] azadirachtin results in decreased expression of TNFRSF11A mRNA
CTD
PMID:31225646
NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
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Tp53
tumor protein p53
increases expression
ISO
azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein
CTD
PMID:20429769
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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