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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetonitrile
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Accession:CHEBI:38472 term browser browse the term
Definition:A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.
Synonyms:related_synonym: CH3-C#N;   Formula=C2H3N;   InChI=1S/C2H3N/c1-2-3/h1H3;   InChIKey=WEVYAHXRMPXWCK-UHFFFAOYSA-N;   MeCN;   NCMe;   SMILES=CC#N;   cyanomethane;   ethanenitrile;   methyl cyanide
 alt_id: CHEBI:22185;   CHEBI:30972;   CHEBI:41432
 xref: Beilstein:741857;   CAS:75-05-8;   Gmelin:895
 xref_mesh: MESH:C032159
 xref: PDBeChem:CCN;   PMID:17347819;   PMID:19100763;   PMID:20370615;   PMID:985423;   PPDB:1349;   Reaxys:741857;   Wikipedia:Acetonitrile



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acetonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP acetonitrile inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP
acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
CTD PMID:9143349 PMID:19858067 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Nefh neurofilament heavy chain affects expression EXP acetonitrile affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO acetonitrile results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
decreases activity
ISO acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
acetonitrile results in decreased activity of SULT1A1 protein
CTD PMID:14570759 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene] CTD PMID:14570759 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
phoxim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein CTD PMID:15793557 PMID:33497710 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arl6ip5 ARF like GTPase 6 interacting protein 5 affects expression ISO phoxim affects the expression of ARL6IP5 protein CTD PMID:15799245 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of BCHE protein CTD PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions
ISO phoxim results in increased expression of CEBPA protein
Fulvestrant inhibits the reaction [phoxim results in increased expression of CEBPA protein]
CTD PMID:33872936 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cldn4 claudin 4 decreases expression
multiple interactions
EXP phoxim results in decreased expression of CLDN4 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]
CTD PMID:30003487 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP phoxim results in increased expression of CYP2B1 mRNA CTD PMID:36356836 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO phoxim binds to and results in increased activity of ESR1 protein
phoxim binds to ESR1 protein
CTD PMID:33049310 PMID:33872936 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO phoxim results in increased expression of FAS mRNA
Fulvestrant inhibits the reaction [phoxim results in increased expression of FAS mRNA]
CTD PMID:33872936 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions
EXP phoxim results in increased expression of GPX2 mRNA
Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]
CTD PMID:30003487 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phoxim results in decreased expression of IL1B mRNA CTD PMID:30003487 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP phoxim results in decreased expression of IL6 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]
CTD PMID:30003487 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions
ISO phoxim results in increased expression of LPL mRNA
Fulvestrant inhibits the reaction [phoxim results in increased expression of LPL mRNA]
CTD PMID:33872936 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP phoxim results in increased expression of NFE2L2 mRNA CTD PMID:30003487 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phoxim binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA] CTD PMID:30003487 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Plin1 perilipin 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [phoxim results in increased expression of PLIN1 protein]; tolclofos-methyl inhibits the reaction [phoxim results in increased expression of PLIN1 protein] CTD PMID:33872936 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO phoxim binds to and results in increased activity of PPARG protein
Fulvestrant inhibits the reaction [phoxim results in increased expression of PPARG protein]; phoxim binds to and results in increased activity of PPARG protein
CTD PMID:33049310 PMID:33872936 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO phoxim binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein]
phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein
CTD PMID:30003487 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 affects activity ISO phoxim metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        solvent 17232
          polar solvent 15707
            polar aprotic solvent 630
              acetonitrile 31
                (2-methylphenyl)acetonitrile 0
                (hydroxyimino)(phenyl)acetonitrile + 22
                2-thienylacetonitrile 0
                3-phenylpropionitrile + 0
                4-chlorophenylacetonitrile 0
                [5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile 0
                acetonitrile oxide 0
                acetonitrile sulfide 0
                iminodiacetonitrile 0
                indole-3-acetonitrile + 0
                phenylacetonitrile + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            one-carbon compound 17863
                              hydrogen cyanide 4795
                                cyanides 4778
                                  nitrile 4580
                                    aliphatic nitrile 2200
                                      acetonitrile 31
                                        (2-methylphenyl)acetonitrile 0
                                        (hydroxyimino)(phenyl)acetonitrile + 22
                                        2-thienylacetonitrile 0
                                        3-phenylpropionitrile + 0
                                        4-chlorophenylacetonitrile 0
                                        [5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile 0
                                        acetonitrile oxide 0
                                        acetonitrile sulfide 0
                                        iminodiacetonitrile 0
                                        indole-3-acetonitrile + 0
                                        phenylacetonitrile + 0
paths to the root