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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:usnic acid
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Accession:CHEBI:38319 term browser browse the term
Definition:A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.
Synonyms:exact_synonym: 2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one
 related_synonym: Formula=C18H16O7;   InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,21-23H,1-4H3;   InChIKey=WEYVVCKOOFYHRW-UHFFFAOYSA-N;   SMILES=CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)C2(C)C1=O;   Usninsaeure;   usnein;   usniacin;   usninic acid
 xref: Beilstein:346490;   CAS:125-46-2
 xref_mesh: MESH:C073339
 xref: PMID:11034349;   PMID:18887895;   PMID:19034791;   PMID:19349177;   PMID:20379653;   PMID:24770718;   Reaxys:96699;   Wikipedia:Usnic_acid


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usnic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:25078063 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO usnic acid results in increased expression of APAF1 mRNA CTD PMID:32508146 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein] CTD PMID:25870318 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions
increases expression		 ISO usnic acid results in increased phosphorylation of ATM protein
Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
usnic acid results in increased expression of ATM mRNA		 CTD PMID:31715134 PMID:32508146 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 decreases expression ISO usnic acid results in decreased expression of BABAM2 mRNA CTD PMID:32508146 NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951 		JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO usnic acid results in decreased expression of BAG1 mRNA CTD PMID:32508146 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bag3 BAG cochaperone 3 decreases expression ISO usnic acid results in decreased expression of BAG3 mRNA CTD PMID:32508146 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO usnic acid results in decreased expression of BAG4 mRNA CTD PMID:32508146 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO usnic acid results in increased expression of BAK1 mRNA CTD PMID:32508146 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression		 ISO usnic acid results in decreased expression of BAX protein
usnic acid results in increased expression of BAX mRNA; usnic acid results in increased expression of BAX protein		 CTD PMID:22285236 PMID:31715134 PMID:32508146 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression ISO usnic acid results in increased expression of BCL10 mRNA CTD PMID:32508146 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO usnic acid results in decreased expression of BCL2 mRNA; usnic acid results in decreased expression of BCL2 protein CTD PMID:22285236 PMID:25078063 PMID:31715134 PMID:32508146 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO usnic acid results in decreased expression of BCL2A1 mRNA CTD PMID:32508146 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression ISO usnic acid results in decreased expression of BCL2L11 mRNA CTD PMID:32508146 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO usnic acid results in increased expression of BCL2L2 mRNA CTD PMID:32508146 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bfar bifunctional apoptosis regulator increases expression ISO usnic acid results in increased expression of BFAR mRNA CTD PMID:32508146 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO usnic acid results in increased expression of BIK mRNA CTD PMID:32508146 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO usnic acid results in decreased expression of BIRC2 mRNA CTD PMID:32508146 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO usnic acid results in decreased expression of BIRC3 mRNA CTD PMID:32508146 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO usnic acid results in decreased expression of BIRC5 mRNA CTD PMID:32508146 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK increases expression ISO usnic acid results in increased expression of BOK mRNA CTD PMID:32508146 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp1 caspase 1 increases expression ISO usnic acid results in increased expression of CASP1 mRNA CTD PMID:32508146 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases expression ISO usnic acid results in increased expression of CASP2 mRNA CTD PMID:32508146 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]
usnic acid results in increased expression of CASP3 mRNA; usnic acid results in increased expression of CASP3 protein		 CTD PMID:22285236 PMID:25078063 PMID:25870318 PMID:32508146 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases cleavage
increases expression		 ISO usnic acid results in increased cleavage of CASP4 protein
usnic acid results in increased expression of CASP4 mRNA		 CTD PMID:25870318 PMID:32508146 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 decreases expression ISO usnic acid results in decreased expression of CASP6 mRNA CTD PMID:32508146 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
decreases expression		 ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein]
usnic acid results in decreased expression of CASP7 mRNA		 CTD PMID:25078063 PMID:25870318 PMID:32508146 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 decreases expression ISO usnic acid results in decreased expression of CASP8 mRNA CTD PMID:32508146 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO usnic acid results in increased expression of CASP8AP2 mRNA CTD PMID:32508146 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Casp9 caspase 9 decreases expression
increases expression		 ISO usnic acid results in decreased expression of CASP9 mRNA
usnic acid results in increased expression of CASP9 protein		 CTD PMID:32508146 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions
increases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA
usnic acid results in increased expression of CCL21 mRNA		 CTD PMID:21953288 PMID:22777745 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA CTD PMID:22777745 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccnc cyclin C multiple interactions
increases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CCNC mRNA
usnic acid results in increased expression of CCNC mRNA		 CTD PMID:21953288 PMID:22777745 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO usnic acid results in decreased expression of CCND1 protein CTD PMID:27369375 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO usnic acid results in decreased expression of CCND3 protein CTD PMID:27369375 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cd40 CD40 molecule increases expression ISO usnic acid results in increased expression of CD40 mRNA CTD PMID:32508146 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO usnic acid results in increased expression of CD70 mRNA CTD PMID:32508146 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO usnic acid results in decreased expression of CDK2 protein CTD PMID:27369375 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO usnic acid results in decreased expression of CDK4 protein CTD PMID:27369375 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO usnic acid results in decreased expression of CDK6 protein CTD PMID:27369375 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO usnic acid results in increased expression of CHEK1 mRNA; usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 PMID:32508146 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions		 ISO usnic acid results in increased expression of CHEK2 mRNA; usnic acid results in increased expression of CHEK2 protein; usnic acid results in increased expression of CHEK2 protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]		 CTD PMID:27369375 PMID:31715134 PMID:32508146 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO usnic acid results in increased expression of CIDEA mRNA CTD PMID:32508146 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO usnic acid results in increased expression of CIDEB mRNA CTD PMID:32508146 NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression ISO usnic acid results in increased expression of CRADD mRNA CTD PMID:32508146 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CRYAB mRNA CTD PMID:22777745 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CSF2 mRNA
usnic acid results in decreased expression of CSF2 mRNA		 CTD PMID:21953288 PMID:22777745 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CXCL10 mRNA CTD PMID:22777745 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO usnic acid results in decreased expression of CYP1A1 mRNA CTD PMID:21953288 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA
usnic acid results in decreased expression of CYP2E1 mRNA		 CTD PMID:21953288 PMID:22777745 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA CTD PMID:22777745 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dapk2 death-associated protein kinase 2 increases expression ISO usnic acid results in increased expression of DAPK2 mRNA CTD PMID:32508146 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA CTD PMID:22777745 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of DDIT3 protein]
usnic acid results in increased expression of DDIT3 mRNA; usnic acid results in increased expression of DDIT3 protein		 CTD PMID:25870318 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression ISO usnic acid results in increased expression of DFFA mRNA CTD PMID:32508146 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dffb DNA fragmentation factor subunit beta increases expression ISO usnic acid results in increased expression of DFFB mRNA CTD PMID:32508146 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:25078063 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO usnic acid results in increased expression of FADD mRNA CTD PMID:32508146 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
decreases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FASLG mRNA
usnic acid results in increased expression of FASLG mRNA
usnic acid results in decreased expression of FASLG mRNA		 CTD PMID:22777745 PMID:32508146 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA CTD PMID:22777745 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO usnic acid results in increased expression of GADD45A mRNA CTD PMID:32508146 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]
usnic acid results in increased expression of GCLC mRNA; usnic acid results in increased expression of GCLC protein		 CTD PMID:27369375 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA CTD PMID:22777745 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA
usnic acid results in increased expression of GSR protein		 CTD PMID:22777745 PMID:27369375 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO usnic acid results in increased expression of GSTA1 protein CTD PMID:27369375 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO usnic acid results in increased expression of H2AX protein; usnic acid results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein]; NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]		 CTD PMID:27369375 PMID:31715134 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression ISO usnic acid results in increased expression of HRK mRNA CTD PMID:32508146 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSP90AB1 mRNA CTD PMID:22777745 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNA CTD PMID:22777745 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA CTD PMID:22777745 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA CTD PMID:22777745 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA CTD PMID:22777745 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA CTD PMID:22777745 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA CTD PMID:22777745 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1B mRNA CTD PMID:22777745 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL6 mRNA CTD PMID:22777745 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lta lymphotoxin alpha multiple interactions
increases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA
usnic acid results in increased expression of LTA mRNA		 CTD PMID:22777745 PMID:32508146 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Ltbr lymphotoxin beta receptor increases expression ISO usnic acid results in increased expression of LTBR mRNA CTD PMID:32508146 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK1 protein CTD PMID:25078063 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK3 protein CTD PMID:25078063 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
increases expression		 ISO 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein]
usnic acid results in increased expression of MCL1 mRNA		 CTD PMID:25078063 PMID:32508146 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16169175 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein CTD PMID:25078063 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression ISO usnic acid results in decreased expression of NAIP mRNA CTD PMID:32508146 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]; NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]; usnic acid results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:27369375 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 increases expression ISO usnic acid results in increased expression of NOD1 mRNA CTD PMID:32508146 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of NOS2 mRNA
usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]		 CTD PMID:16169175 PMID:22777745 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO usnic acid results in increased expression of NQO1 protein CTD PMID:27369375 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 increases expression
multiple interactions		 ISO
EXP		 usnic acid results in increased expression of ORAI1 protein
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]		 CTD PMID:25870318 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO usnic acid results in increased cleavage of PARP1 protein CTD PMID:31715134 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of PDK1 protein CTD PMID:25078063 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA CTD PMID:22777745 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression
multiple interactions		 ISO usnic acid results in increased expression of PRKDC protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]		 CTD PMID:31715134 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA CTD PMID:22777745 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of RAD50 mRNA CTD PMID:22777745 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression ISO usnic acid results in increased expression of RIPK2 mRNA CTD PMID:32508146 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rpa3 replication protein A3 increases expression ISO usnic acid results in increased expression of RPA3 mRNA CTD PMID:32508146 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25078063 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA CTD PMID:22777745 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO usnic acid results in increased degradation of SQSTM1 protein CTD PMID:25078063 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stim1 stromal interaction molecule 1 increases expression ISO
EXP		 usnic acid results in increased expression of STIM1 protein CTD PMID:25870318 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Tank TRAF family member-associated NFKB activator increases expression ISO usnic acid results in increased expression of TANK mRNA CTD PMID:32508146 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of TNF mRNA
usnic acid results in decreased expression of TNF mRNA		 CTD PMID:22777745 PMID:32508146 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO usnic acid results in increased expression of TNFRSF10A mRNA CTD PMID:32508146 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO usnic acid results in increased expression of TNFRSF11B mRNA CTD PMID:32508146 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO usnic acid results in increased expression of TNFRSF1A mRNA CTD PMID:32508146 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 increases expression ISO usnic acid results in increased expression of TNFRSF21 mRNA CTD PMID:32508146 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085 		JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 increases expression ISO usnic acid results in increased expression of TNFRSF10C mRNA CTD PMID:32508146 NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 increases expression ISO usnic acid results in increased expression of TNFRSF8 mRNA CTD PMID:32508146 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO usnic acid results in increased expression of TNFRSF9 mRNA CTD PMID:32508146 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO usnic acid results in increased expression of TNFSF10 mRNA CTD PMID:32508146 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf13 TNF superfamily member 13 increases expression ISO usnic acid results in increased expression of TNFSF13 mRNA CTD PMID:32508146 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tnfsf15 TNF superfamily member 15 increases expression ISO usnic acid results in increased expression of TNFSF15 mRNA CTD PMID:32508146 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
G Tnfsf4 TNF superfamily member 4 increases expression ISO usnic acid results in increased expression of TNFSF4 mRNA CTD PMID:32508146 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tnfsf8 TNF superfamily member 8 increases expression ISO usnic acid results in increased expression of TNFSF8 mRNA CTD PMID:32508146 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions		 ISO usnic acid results in decreased expression of TP53 protein
usnic acid results in increased expression of TP53 mRNA; usnic acid results in increased expression of TP53 protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]		 CTD PMID:22285236 PMID:31715134 PMID:32508146 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 increases expression ISO usnic acid results in increased expression of TP63 mRNA CTD PMID:32508146 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 increases expression ISO usnic acid results in increased expression of TRAF3 mRNA CTD PMID:32508146 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf5 TNF receptor-associated factor 5 increases expression ISO usnic acid results in increased expression of TRAF5 mRNA CTD PMID:32508146 NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression ISO usnic acid results in increased expression of TRAF6 mRNA CTD PMID:32508146 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression		 ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA
usnic acid results in increased expression of UGT1A4 mRNA		 CTD PMID:21953288 PMID:22777745 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO usnic acid results in increased splicing of XBP1 mRNA CTD PMID:25870318 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA CTD PMID:22777745 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pesticide 18090
          acaricide 13726
            usnic acid 125
              (+)-usnic acid 0
              (-)-usnic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterotricyclic compound 15876
                                      dibenzofurans 2503
                                        usnic acid 125
                                          (+)-usnic acid 0
                                          (-)-usnic acid 0
paths to the root