Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imidazolyl carboxylic acid
go back to main search page
Accession:CHEBI:38307 term browser browse the term
Definition:Any member of the class of imidazoles in which the imidazole ring is substituted by one (or more) carboxy group(s).
Synonyms:related_synonym: imidazolyl carboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:38466


show annotations for term's descendants           Sort by:
etomidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]; Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Etomidate CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO Etomidate results in decreased expression of CLDN1 protein CTD PMID:38604439 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO Etomidate results in decreased expression of CLDN4 protein CTD PMID:38604439 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP		 Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:10049148 PMID:12939268 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
affects response to substance		 ISO Etomidate binds to and results in increased activity of GABRA5 protein
GABRA5 protein affects the susceptibility to Etomidate		 CTD PMID:16597725 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]] CTD PMID:10049148 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions		 ISO
EXP		 GABRB2 protein affects the susceptibility to Etomidate
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:12490572 PMID:12939268 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance
multiple interactions		 ISO GABRB3 protein results in increased susceptibility to Etomidate
Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]		 CTD PMID:9523823 PMID:21111751 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]] CTD PMID:10049148 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP		 Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:10049148 PMID:12939268 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Stx1a syntaxin 1A affects localization EXP Etomidate affects the localization of STX1A protein CTD PMID:29320738 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Etomidate results in decreased expression of TJP1 protein CTD PMID:38604439 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      chemical role 19498
        donor 18950
          Bronsted acid 18830
            oxoacid 18804
              carbon oxoacid 18678
                carboxylic acid 18675
                  aromatic carboxylic acid 12753
                    imidazolyl carboxylic acid 14
                      1,4-Methylimidazoleacetic acid 0
                      1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid + 14
                      1-methyl-5-imidazoleacetic acid 0
                      1-methyl-imidazole-2-carboxylic acid 0
                      1-methyl-imidazole-4-carboxylic acid 0
                      1-methylimidazol-4-ylacetic acid 0
                      2-(2-oxo-2-\{[2-(2-oxo-1-imidazolidinyl)ethyl]amino\}ethoxy)acetic acid 0
                      3-(1H-imidazol-1-yl)propanoic acid 0
                      3-(imidazol-1-yl)lactic acid 0
                      3-(imidazol-1-yl)pyruvic acid 0
                      5-methyl-imidazole-2-carboxylic acid 0
                      5-methyl-imidazole-4-carboxylic acid 0
                      Fungerin 0
                      Hydroxyfungerin A 0
                      Hydroxyfungerin B 0
                      Visoltricin 0
                      imidazol-1-ylacetic acid 0
                      imidazole-4-carboxylic acid + 0
                      zolasartan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  heteroarene 17176
                                    monocyclic heteroarene 15001
                                      azole 14525
                                        diazole 10786
                                          imidazoles 10236
                                            imidazolyl carboxylic acid 14
                                              1,4-Methylimidazoleacetic acid 0
                                              1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid + 14
                                              1-methyl-5-imidazoleacetic acid 0
                                              1-methyl-imidazole-2-carboxylic acid 0
                                              1-methyl-imidazole-4-carboxylic acid 0
                                              1-methylimidazol-4-ylacetic acid 0
                                              2-(2-oxo-2-\{[2-(2-oxo-1-imidazolidinyl)ethyl]amino\}ethoxy)acetic acid 0
                                              3-(1H-imidazol-1-yl)propanoic acid 0
                                              3-(imidazol-1-yl)lactic acid 0
                                              3-(imidazol-1-yl)pyruvic acid 0
                                              5-methyl-imidazole-2-carboxylic acid 0
                                              5-methyl-imidazole-4-carboxylic acid 0
                                              Fungerin 0
                                              Hydroxyfungerin A 0
                                              Hydroxyfungerin B 0
                                              Visoltricin 0
                                              imidazol-1-ylacetic acid 0
                                              imidazole-4-carboxylic acid + 0
                                              zolasartan 0
paths to the root