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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:physcion
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Accession:CHEBI:38167 term browser browse the term
Definition:A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms:exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;   1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;   1,8-dihydroxy-3-methyl-6-methoxyanthraquinone;   Emodin monomethyl ether;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3;   InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N;   Parienin;   Physcione;   Rheochrysidin;   SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O;   parietin
 alt_id: CHEBI:68791
 xref: CAS:521-61-9;   KEGG:C17045
 xref_mesh: MESH:C008905
 xref: PMID:16272711;   PMID:17091434;   PMID:17125234;   PMID:17397111;   PMID:17917292;   PMID:17949858;   PMID:17978503;   PMID:17978527;   PMID:18556196;   PMID:18612943;   PMID:19402184;   PMID:19463000;   PMID:19505563;   PMID:20024894;   PMID:20205209;   PMID:20392467;   PMID:20532365;   PMID:21106380;   PMID:21117944;   PMID:21253951;   PMID:21273951;   PMID:21725807;   PMID:21765390;   PMID:21840387;   PMID:22850859;   PMID:23993502;   PMID:24071573;   PMID:25574462;   PMID:25860944;   PMID:26144377;   PMID:26707141;   PMID:26836455;   PMID:27231648;   PMID:27352350;   PMID:27490539;   PMID:27548142;   PMID:27657824;   PMID:27694907;   PMID:27904770;   Reaxys:1915778


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physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression 		ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein 		CTD PMID:22285236 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO physcione results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        anti-inflammatory agent 16840
          physcion 14
            physcion 8-gentiobioside 0
            torososide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbonyl compound 19441
                                    ketone 17465
                                      cyclic ketone 16066
                                        quinone 9947
                                          acenoquinone 7779
                                            anthraquinone 529
                                              hydroxyanthraquinones 517
                                                dihydroxyanthraquinone 354
                                                  physcion 14
                                                    physcion 8-gentiobioside 0
                                                    torososide B 0
paths to the root