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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cardiotonic drug
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Accession:CHEBI:38147 term browser browse the term
Definition:A drug that has a strengthening effect on the heart or that can increase cardiac output.
Synonyms:related_synonym: cardiotonic drugs


show annotations for term's descendants           Sort by:
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
colforsin daropate hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 decreases activity EXP Colforsin results in decreased activity of ADCYAP1 protein alternative form CTD PMID:16847435 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294 		JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions EXP Colforsin inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G CFTR CF transmembrane conductance regulator increases activity EXP Colforsin results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Digoxin results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases cleavage EXP dihydroouabain results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615 		JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254 		JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Ouabain results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
G CASP3 caspase 3 decreases cleavage EXP Ouabain results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1B adrenoceptor alpha 1B increases activity EXP Phenylephrine results in increased activity of ADRA1B protein CTD PMID:19376108 NCBI chr16:63,550,123...64,010,838
Ensembl chr16:63,550,130...63,603,034 		JBrowse link
G ADRA1D adrenoceptor alpha 1D increases activity EXP Phenylephrine results in increased activity of ADRA1D protein CTD PMID:19376108 NCBI chr17:31,517,021...31,537,361
Ensembl chr17:31,517,021...31,538,362 		JBrowse link
G C5 complement C5 affects response to substance EXP C5 protein affects the susceptibility to Phenylephrine CTD PMID:10750764 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5152
    role 5119
      application 905
        pharmaceutical 740
          drug 740
            cardiovascular drug 98
              cardiotonic drug 12
                3'''-O-acetyldigitoxin 0
                O-propanoylcarnitine + 0
                aminophylline 0
                arbutamine 0
                bucladesine 1
                bufalin 0
                carbachol 0
                cassaidine 0
                cassaine 0
                colforsin daropate 0
                colforsin daropate hydrochloride 4
                deslanoside 0
                diazoxide 0
                digoxin + 1
                dobutamine + 3
                dobutamine hydrochloride 0
                dopamine + 0
                isoprenaline 0
                ivabradine 0
                ivabradine hydrochloride 0
                levosimendan 0
                milrinone + 0
                milrinone lactate 0
                neriifolin + 0
                ouabain + 2
                phenylephrine 3
                pimobendan 0
                solasodine + 0
                sulmazole 0
paths to the root