CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dialdehyde
Accession: CHEBI:38124
browse the term
Definition: Any aldehyde with two aldehyde groups.
Synonyms: related_synonym: bialdehyde; bialdehydes; dialdehydes
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde
CTD
PMID:21842885
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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Fgf1
fibroblast growth factor 1
decreases secretion
ISO
FGF1 protein results in decreased secretion of malealdehyde
CTD
PMID:16222742
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
malealdehyde results in increased expression of GCLC mRNA
CTD
PMID:35750087
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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Gstp1
glutathione S-transferase pi 1
affects expression
ISO
malealdehyde affects the expression of GSTP1 mRNA
CTD
PMID:35750087
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hdac2
histone deacetylase 2
affects expression
ISO
malealdehyde affects the expression of HDAC2 mRNA
CTD
PMID:35750087
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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Hdac8
histone deacetylase 8
increases expression
ISO
malealdehyde results in increased expression of HDAC8 mRNA
CTD
PMID:35750087
NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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Hdac9
histone deacetylase 9
affects expression
ISO
malealdehyde affects the expression of HDAC9 mRNA
CTD
PMID:35750087
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Tp53
tumor protein p53
decreases expression
ISO
malealdehyde results in decreased expression of TP53 mRNA
CTD
PMID:35750087
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Txn1
thioredoxin 1
decreases activity
ISO
malealdehyde results in decreased activity of TXN1 protein
CTD
PMID:27402187
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Atf4
activating transcription factor 4
increases expression
ISO
Glutaral results in increased expression of ATF4 mRNA
CTD
PMID:28236482
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Casp8
caspase 8
decreases expression
ISO
Glutaral results in decreased expression of CASP8 mRNA
CTD
PMID:28236482
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccl4
C-C motif chemokine ligand 4
increases expression
ISO
Glutaral results in increased expression of CCL4 mRNA
CTD
PMID:20713136
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Cd86
CD86 molecule
increases expression
ISO
Glutaral results in increased expression of CD86 protein
CTD
PMID:19665512
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G6pd
glucose-6-phosphate dehydrogenase
decreases activity
ISO
Glutaral results in decreased activity of G6PD protein
CTD
PMID:19490936
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gja1
gap junction protein, alpha 1
decreases expression
EXP
Glutaral results in decreased expression of GJA1 protein
CTD
PMID:19932693
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Gsr
glutathione-disulfide reductase
decreases activity multiple interactions
ISO
Glutaral results in decreased activity of GSR protein Idarubicin promotes the reaction [Glutaral results in decreased activity of GSR protein]
CTD
PMID:19490936
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Il1r2
interleukin 1 receptor type 2
increases expression
ISO
Glutaral results in increased expression of IL1R2 mRNA
CTD
PMID:20713136
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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Il6
interleukin 6
affects expression
ISO
Glutaral affects the expression of IL6 mRNA
CTD
PMID:20200221
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Muc1
mucin 1, cell surface associated
decreases expression increases expression
ISO
Glutaral results in decreased expression of MUC1 protein Glutaral results in increased expression of MUC1 protein
CTD
PMID:38360295
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
Glutaral results in increased expression of PMAIP1 mRNA
CTD
PMID:20713136
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Tnf
tumor necrosis factor
affects expression increases expression
ISO
Glutaral affects the expression of TNF mRNA Glutaral results in increased expression of TNF mRNA
CTD
PMID:20200221 PMID:28236482
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
decreases expression
ISO
Glutaral results in decreased expression of TP53 mRNA
CTD
PMID:28236482
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions increases degradation
ISO
Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] Glyoxal results in increased degradation of ABCA1 protein Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD
PMID:15983222
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Akr1b1
aldo-keto reductase family 1 member B1
increases reduction
ISO
AKR1B1 protein results in increased reduction of Glyoxal
CTD
PMID:10510318
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1c2
aldo-keto reductase family 1, member C2
increases activity increases expression
ISO
Glyoxal results in increased activity of AKR1C2 promoter Glyoxal results in increased expression of AKR1C2 mRNA
CTD
PMID:21195160 PMID:25724174
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal
CTD
PMID:21334317
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Apoa1
apolipoprotein A1
multiple interactions
ISO
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD
PMID:15983222
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Atf3
activating transcription factor 3
increases expression
ISO
Glyoxal results in increased expression of ATF3 mRNA
CTD
PMID:23999411 PMID:27965148
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Camp
cathelicidin antimicrobial peptide
multiple interactions increases expression
EXP
Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein] Glyoxal results in increased expression of CAMP protein
CTD
PMID:29496360
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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Cat
catalase
decreases response to substance
EXP
CAT protein results in decreased susceptibility to Glyoxal
CTD
PMID:21334317
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
Glyoxal results in decreased expression of COL1A1 mRNA
CTD
PMID:28760545
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Ctss
cathepsin S
decreases activity
ISO
Glyoxal results in decreased activity of CTSS protein
CTD
PMID:16671891
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
[CYP2C19 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
multiple interactions
ISO
[CYP2C8 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Defb2
defensin beta 2
multiple interactions increases expression
EXP
Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein] Glyoxal results in increased expression of DEFB2 protein
CTD
PMID:29496360
NCBI chr16:70,231,870...70,245,817
Ensembl chr16:70,231,945...70,245,784
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Glyoxal results in increased expression of DNAJB4 mRNA
CTD
PMID:23999411 PMID:27965148
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Glyoxal results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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Hmox1
heme oxygenase 1
increases expression
ISO
Glyoxal results in increased expression of HMOX1 mRNA
CTD
PMID:23445166 PMID:25724174
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
increases expression
ISO
Glyoxal results in increased expression of HSPA6 mRNA
CTD
PMID:23999411
NCBI chr13:83,273,176...83,274,317
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
Glyoxal results in increased expression of HSPH1 mRNA
CTD
PMID:23999411
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Ifng
interferon gamma
multiple interactions
EXP
[Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA
CTD
PMID:29496360
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il18
interleukin 18
increases expression
ISO
Glyoxal results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1a
interleukin 1 alpha
increases expression
ISO
Glyoxal results in increased expression of IL1A mRNA
CTD
PMID:33715048
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
increases expression
ISO
Glyoxal results in increased expression of IL1B mRNA
CTD
PMID:33715048
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
affects expression
ISO
Glyoxal analog affects the expression of IL6 mRNA
CTD
PMID:20200221
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Mapt
microtubule-associated protein tau
multiple interactions
ISO
Glyoxal promotes the reaction [MAPT protein binds to MAPT protein]
CTD
PMID:17082178
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Tnf
tumor necrosis factor
multiple interactions
EXP
[Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA
CTD
PMID:29496360
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Glyoxal results in increased expression of TXNRD1 mRNA
CTD
PMID:23445166
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein]
CTD
PMID:17070507
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
[ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde
CTD
PMID:26134275
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Acta2
actin alpha 2, smooth muscle
increases expression
EXP
Malondialdehyde results in increased expression of ACTA2 protein
CTD
PMID:7593635
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Agt
angiotensinogen
increases abundance multiple interactions affects binding
EXP ISO
AGT protein results in increased abundance of Malondialdehyde AGT protein modified form results in increased abundance of Malondialdehyde FNDC5 protein inhibits the reaction [AGT protein modified form results in increased abundance of Malondialdehyde] Malondialdehyde binds to AGT protein modified form Atorvastatin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]
CTD
PMID:15607907 PMID:19451411 PMID:26111765 PMID:30354818 PMID:30703374
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]
CTD
PMID:32045588
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
multiple interactions
ISO
ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde]; ALB protein inhibits the reaction [[Iron co-treated with Phosphates] results in increased abundance of Malondialdehyde]
CTD
PMID:16027354
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases metabolic processing increases oxidation
ISO
ALDH1A1 protein results in increased metabolism of Malondialdehyde ALDH1A1 protein results in increased oxidation of Malondialdehyde
CTD
PMID:21256123 PMID:22339434
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh2
aldehyde dehydrogenase 2 family member
increases oxidation
ISO
ALDH2 protein results in increased oxidation of Malondialdehyde
CTD
PMID:22339434
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
increases metabolic processing
ISO
ALDH3A1 protein results in increased metabolism of Malondialdehyde
CTD
PMID:21256123
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Aldh3b1
aldehyde dehydrogenase 3 family, member B1
affects binding
ISO
Malondialdehyde binds to ALDH3B1 protein
CTD
PMID:20699116
NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
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Apc
APC regulator of WNT signaling pathway
affects abundance multiple interactions
ISO
APC protein affects the abundance of Malondialdehyde bis(2-guanidinoethyl)disulfide inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; FeCl tetrakis-2-(triethyleneglycolmonomethylether)pyridylporphyrin inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [APC protein affects the abundance of Malondialdehyde]
CTD
PMID:15063141
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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App
amyloid beta precursor protein
multiple interactions increases abundance
ISO
vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]
CTD
PMID:29545167
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Atp7b
ATPase copper transporting beta
increases abundance
EXP
ATP7B gene mutant form results in increased abundance of Malondialdehyde
CTD
PMID:17303181
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
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Bgn
biglycan
multiple interactions
ISO
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of Malondialdehyde
CTD
PMID:35234341
NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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Cat
catalase
decreases abundance multiple interactions
EXP
CAT protein modified form results in decreased abundance of Malondialdehyde [SOD1 protein modified form co-treated with CAT protein modified form] results in decreased abundance of Malondialdehyde
CTD
PMID:21600015
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd36
CD36 molecule
multiple interactions
ISO
iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of CD36 protein]
CTD
PMID:17070507
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
Malondialdehyde results in decreased expression of COL1A1 mRNA
CTD
PMID:28760545
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
increases expression multiple interactions
EXP
Malondialdehyde results in increased expression of COL1A2 mRNA MAPK8 protein promotes the reaction [Malondialdehyde results in increased expression of COL1A2 mRNA]
CTD
PMID:11295527
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Cp
ceruloplasmin
affects abundance
ISO
CP protein affects the abundance of Malondialdehyde
CTD
PMID:12572680
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cybb
cytochrome b-245 beta chain
increases abundance
ISO
CYBB protein results in increased abundance of Malondialdehyde
CTD
PMID:19417757
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Ddah2
DDAH family member 2, ADMA-independent
multiple interactions
ISO
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]
CTD
PMID:32135237
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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Eef2
eukaryotic translation elongation factor 2
decreases expression
EXP
Malondialdehyde results in decreased expression of EEF2 protein
CTD
PMID:16469450
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
multiple interactions
ISO
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde
CTD
PMID:25411909
NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
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Epo
erythropoietin
decreases abundance
ISO
EPO protein results in decreased abundance of Malondialdehyde
CTD
PMID:22013135
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Fndc5
fibronectin type III domain containing 5
multiple interactions decreases abundance
ISO EXP
FNDC5 protein inhibits the reaction [AGT protein modified form results in increased abundance of Malondialdehyde] FNDC5 protein results in decreased abundance of Malondialdehyde NFE2L2 protein promotes the reaction [FNDC5 protein results in decreased abundance of Malondialdehyde]
CTD
PMID:30703374 PMID:32165127
NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
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Foxo3
forkhead box O3
multiple interactions
ISO
FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]]
CTD
PMID:24633890
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Gclm
glutamate cysteine ligase, modifier subunit
affects abundance
ISO
GCLM gene polymorphism affects the abundance of Malondialdehyde
CTD
PMID:25728017
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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Ghrl
ghrelin and obestatin prepropeptide
decreases abundance
EXP
GHRL results in decreased abundance of Malondialdehyde
CTD
PMID:16868036
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
G
Gjb1
gap junction protein, beta 1
decreases abundance
ISO
GJB1 protein results in decreased abundance of Malondialdehyde
CTD
PMID:27859493
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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Gstt1
glutathione S-transferase theta 1
affects abundance
ISO
GSTT1 gene polymorphism affects the abundance of Malondialdehyde
CTD
PMID:25728017
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
decreases activity
ISO
Malondialdehyde results in decreased activity of H6PD protein
CTD
PMID:20211231
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]
CTD
PMID:15602829
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
multiple interactions
ISO
[Trichloroethylene co-treated with Malondialdehyde analog] results in increased expression of IFNG protein
CTD
PMID:18267128
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
increases abundance
ISO
IL1B gene mutant form results in increased abundance of Malondialdehyde
CTD
PMID:37540211
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
decreases abundance
ISO
IL1RN protein results in decreased abundance of Malondialdehyde
CTD
PMID:18474811
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il2
interleukin 2
multiple interactions
ISO
[Trichloroethylene co-treated with Malondialdehyde analog] results in increased expression of IL2 protein
CTD
PMID:18267128
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
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Kl
Klotho
multiple interactions increases abundance
ISO
Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]; H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]]
CTD
PMID:25309793
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
MAPK8 protein promotes the reaction [Malondialdehyde results in increased expression of COL1A2 mRNA]
CTD
PMID:11295527
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapt
microtubule-associated protein tau
multiple interactions
ISO
Malondialdehyde promotes the reaction [MAPT protein binds to MAPT protein]
CTD
PMID:17082178
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Met
MET proto-oncogene, receptor tyrosine kinase
multiple interactions
ISO
[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]
CTD
PMID:32045588
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mettl14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
multiple interactions
ISO
METTL14 protein promotes the reaction [Doxorubicin results in increased abundance of Malondialdehyde]
CTD
PMID:34648132
NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821
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Mical2
microtubule associated monooxygenase, calponin and LIM domain containing 2
multiple interactions
ISO
MICAL2 mRNA promotes the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]
CTD
PMID:32659284
NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719 Ensembl chr 1:166,345,859...166,471,719
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Mir141
microRNA 141
increases abundance
ISO
MIR141 mRNA results in increased abundance of Malondialdehyde
CTD
PMID:26548909
NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
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Mir203-2
microRNA 203-2
multiple interactions
ISO
MIR203 mRNA inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]
CTD
PMID:32659284
NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656
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Myb
MYB proto-oncogene, transcription factor
increases expression
EXP
Malondialdehyde results in increased expression of MYB protein
CTD
PMID:7593635
NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO EXP
NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] NFE2L2 protein promotes the reaction [FNDC5 protein results in decreased abundance of Malondialdehyde]
CTD
PMID:24633890 PMID:32165127
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
decreases expression
ISO
Malondialdehyde results in decreased expression of NOS2 protein
CTD
PMID:20940037
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Otub1
OTU deubiquitinase, ubiquitin aldehyde binding 1
multiple interactions
ISO
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of Malondialdehyde
CTD
PMID:35234341
NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
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Pon1
paraoxonase 1
multiple interactions
ISO
PON1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]
CTD
PMID:20079818
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Pon3
paraoxonase 3
multiple interactions
ISO
PON3 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]
CTD
PMID:20079818
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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Prkd2
protein kinase D2
multiple interactions
ISO
[PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the abundance of Malondialdehyde
CTD
PMID:37951334
NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376
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Pten
phosphatase and tensin homolog
increases abundance
ISO
PTEN mutant form results in increased abundance of Malondialdehyde
CTD
PMID:26548909
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Selenom
selenoprotein M
multiple interactions
ISO
[SELENOM protein affects the susceptibility to Melatonin] which affects the abundance of Malondialdehyde
CTD
PMID:36504304
NCBI chr14:78,395,826...78,398,429
Ensembl chr14:78,395,826...78,398,429
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Shc1
SHC adaptor protein 1
multiple interactions
ISO
SHC1 protein promotes the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]
CTD
PMID:32659284
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Sirt1
sirtuin 1
multiple interactions
ISO
SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]
CTD
PMID:24633890
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc7a11
solute carrier family 7 member 11
multiple interactions
ISO
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of Malondialdehyde
CTD
PMID:35234341
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Sod1
superoxide dismutase 1
multiple interactions decreases abundance
EXP
[SOD1 protein modified form co-treated with CAT protein modified form] results in decreased abundance of Malondialdehyde SOD1 protein modified form results in decreased abundance of Malondialdehyde
CTD
PMID:21600015
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Tbx2
T-box transcription factor 2
multiple interactions
EXP
TBX2 protein promotes the reaction [Sevoflurane results in increased abundance of Malondialdehyde]
CTD
PMID:37494465
NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529
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Tgfb1
transforming growth factor, beta 1
multiple interactions increases abundance
ISO
delphinidin inhibits the reaction [TGFB1 results in increased abundance of Malondialdehyde]
CTD
PMID:30365941
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions increases abundance
ISO
Acetylcysteine inhibits the reaction [TNF results in increased abundance of Malondialdehyde]
CTD
PMID:17026986
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases mutagenesis
ISO
Malondialdehyde results in increased mutagenesis of TP53 gene
CTD
PMID:30658077
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Xrcc1
X-ray repair cross complementing 1
decreases abundance multiple interactions increases abundance
ISO
XRCC1 protein results in decreased abundance of Malondialdehyde Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in increased abundance of Malondialdehyde]; Acetylcysteine promotes the reaction [XRCC1 protein results in decreased abundance of Malondialdehyde]
CTD
PMID:30998386
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Aicda
activation-induced cytidine deaminase
affects expression
ISO
o-Phthalaldehyde affects the expression of AICDA mRNA
CTD
PMID:22302311
NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
G
Akr1c3
aldo-keto reductase family 1, member C3
affects expression
ISO
o-Phthalaldehyde affects the expression of AKR1C18 mRNA
CTD
PMID:22302311
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Ccl9
C-C motif chemokine ligand 9
affects expression
ISO
o-Phthalaldehyde affects the expression of CCL6 mRNA
CTD
PMID:22302311
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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Ccna2
cyclin A2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNA2 mRNA
CTD
PMID:22302311
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNB1 mRNA
CTD
PMID:22302311
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccne2
cyclin E2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNE2 mRNA
CTD
PMID:22302311
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Ccr4
C-C motif chemokine receptor 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CCR4 mRNA
CTD
PMID:22302311
NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
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Cd207
CD207 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD207 mRNA
CTD
PMID:22302311
NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518
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Cd5l
Cd5 molecule-like
affects expression
ISO
o-Phthalaldehyde affects the expression of CD5L mRNA
CTD
PMID:22302311
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
G
Cd83
CD83 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD83 mRNA
CTD
PMID:22302311
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cdc20
cell division cycle 20
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC20 mRNA
CTD
PMID:22302311
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdc25c
cell division cycle 25C
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC25C mRNA
CTD
PMID:22302311
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
G
Cdk1
cyclin-dependent kinase 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CDK1 mRNA
CTD
PMID:22302311
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Clec7a
C-type lectin domain containing 7A
affects expression
ISO
o-Phthalaldehyde affects the expression of CLEC7A mRNA
CTD
PMID:22302311
NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
G
Col8a1
collagen type VIII alpha 1 chain
affects expression
ISO
o-Phthalaldehyde affects the expression of COL8A1 mRNA
CTD
PMID:22302311
NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
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Cphx1
cytoplasmic polyadenylated homeobox 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CPHX1 mRNA
CTD
PMID:22302311
NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CTLA4 mRNA
CTD
PMID:22302311
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA
CTD
PMID:20112102
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA
CTD
PMID:20112102
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Dio1
iodothyronine deiodinase 1
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO1 protein
CTD
PMID:30561685
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
G
Dio2
iodothyronine deiodinase 2
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO2 protein
CTD
PMID:30561685
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
G
Dio3
iodothyronine deiodinase 3
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO3 protein
CTD
PMID:30561685
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
G
E2f1
E2F transcription factor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of E2F1 mRNA
CTD
PMID:22302311
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
Fabp7
fatty acid binding protein 7
affects expression
ISO
o-Phthalaldehyde affects the expression of FABP7 mRNA
CTD
PMID:22302311
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
G
Fxyd4
FXYD domain-containing ion transport regulator 4
affects expression
ISO
o-Phthalaldehyde affects the expression of FXYD4 mRNA
CTD
PMID:22302311
NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
G
Gzmb
granzyme B
affects expression
ISO
o-Phthalaldehyde affects the expression of GZMB mRNA
CTD
PMID:22302311
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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Ifng
interferon gamma
increases expression
ISO
o-Phthalaldehyde results in increased expression of IFNG mRNA
CTD
PMID:21785612
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL10 mRNA
CTD
PMID:21785612
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il12b
interleukin 12B
affects expression
ISO
o-Phthalaldehyde affects the expression of IL12B mRNA
CTD
PMID:22302311
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il13
interleukin 13
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL13 mRNA
CTD
PMID:21785612
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL1B mRNA
CTD
PMID:21785612
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il21
interleukin 21
affects expression
ISO
o-Phthalaldehyde affects the expression of IL21 mRNA
CTD
PMID:22302311
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
G
Il2ra
interleukin 2 receptor subunit alpha
affects expression
ISO
o-Phthalaldehyde affects the expression of IL2RA mRNA
CTD
PMID:22302311
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il4
interleukin 4
affects expression increases expression
ISO
o-Phthalaldehyde affects the expression of IL4 mRNA o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein
CTD
PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5
interleukin 5
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL5 mRNA
CTD
PMID:19110043 PMID:21785612
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Itgav
integrin subunit alpha V
affects expression
ISO
o-Phthalaldehyde affects the expression of ITGAV mRNA
CTD
PMID:22302311
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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Lgals7
galectin 7
affects expression
ISO
o-Phthalaldehyde affects the expression of LGALS7 mRNA
CTD
PMID:22302311
NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015
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Mki67
marker of proliferation Ki-67
affects expression
ISO
o-Phthalaldehyde affects the expression of MKI67 mRNA
CTD
PMID:22302311
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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Nts
neurotensin
affects expression
ISO
o-Phthalaldehyde affects the expression of NTS mRNA
CTD
PMID:22302311
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
G
Thbs1
thrombospondin 1
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS1 mRNA
CTD
PMID:22302311
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Thbs4
thrombospondin 4
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS4 mRNA
CTD
PMID:22302311
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
G
Timd2
T-cell immunoglobulin and mucin domain containing 2
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMD2 mRNA
CTD
PMID:22302311
NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
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Timp1
TIMP metallopeptidase inhibitor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMP1 mRNA
CTD
PMID:22302311
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tnf
tumor necrosis factor
increases expression
ISO
o-Phthalaldehyde results in increased expression of TNF mRNA
CTD
PMID:21785612
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
affects activity
ISO
o-Phthalaldehyde affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Trpm6
transient receptor potential cation channel, subfamily M, member 6
affects expression
ISO
o-Phthalaldehyde affects the expression of TRPM6 mRNA
CTD
PMID:22302311
NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520
G
Il1b
interleukin 1 beta
multiple interactions
ISO
scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD
PMID:7575673
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Mpo
myeloperoxidase
multiple interactions
ISO
scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
CTD
PMID:8113982
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]
CTD
PMID:7575673
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Tnf
tumor necrosis factor
multiple interactions
ISO
scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:7575673
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19899
role
19870
application
19713
solvent
17274
formic acid
9427
formyl group
9388
aldehyde
9388
dialdehyde
141
(6E)-8-oxogeranial
0
2,5-diformylfuran
0
2,6,10-trimethyldodeca-2,4,6,8,10-pentaenedial
0
2,6-dimethyldeca-2,4,6,8-tetraenedial
0
2,6-dimethylocta-2,4,6-trienedial
0
4,4'-diapolycopenedial
0
4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
0
4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde
0
4-methylocta-2,4,6-trienedial
0
aflatoxin B1 dialdehyde
0
aflatoxin B1 dialdehyde(1-)
0
bixin dialdehyde
0
botrydial
0
but-2-enedial +
9
crocetin dialdehyde
0
dolichodial
0
glutaraldehyde
13
glyoxal +
27
iridodial +
0
malonaldehyde
62
oleocanthal
0
oleuropein (dialdehyde form)
0
phthalaldehyde
47
scalaradial
4
Path 2
CHEBI ontology
19899
subatomic particle
19897
composite particle
19897
hadron
19897
baryon
19897
nucleon
19897
atomic nucleus
19897
atom
19897
main group element atom
19836
p-block element atom
19836
carbon group element atom
19776
carbon atom
19772
organic molecular entity
19772
heteroorganic entity
19537
organochalcogen compound
19297
organooxygen compound
19215
carbon oxoacid
18693
carboxylic acid
18690
carboacyl group
17730
univalent carboacyl group
17730
formyl group
9388
aldehyde
9388
dialdehyde
141
(6E)-8-oxogeranial
0
2,5-diformylfuran
0
2,6,10-trimethyldodeca-2,4,6,8,10-pentaenedial
0
2,6-dimethyldeca-2,4,6,8-tetraenedial
0
2,6-dimethylocta-2,4,6-trienedial
0
4,4'-diapolycopenedial
0
4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
0
4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde
0
4-methylocta-2,4,6-trienedial
0
aflatoxin B1 dialdehyde
0
aflatoxin B1 dialdehyde(1-)
0
bixin dialdehyde
0
botrydial
0
but-2-enedial +
9
crocetin dialdehyde
0
dolichodial
0
glutaraldehyde
13
glyoxal +
27
iridodial +
0
malonaldehyde
62
oleocanthal
0
oleuropein (dialdehyde form)
0
phthalaldehyde
47
scalaradial
4