CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: gitoxigenin
Accession: CHEBI:38105
browse the term
Definition: A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms: exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
related_synonym: 16beta-Hydroxydigitoxigenin; Formula=C23H34O5; InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1; InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N; SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
xref: Beilstein:96483; CAS:545-26-6
G
Casp3
caspase 3
increases activity
ISO
oleandrin results in increased activity of CASP3 protein
CTD
PMID:24172227
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
oleandrin results in increased activity of CASP8 protein
CTD
PMID:24172227
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Cxcr1
C-X-C motif chemokine receptor 1
increases expression
ISO
oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein
CTD
PMID:24172227
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
G
Cxcr2
C-X-C motif chemokine receptor 2
increases expression
ISO
oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein
CTD
PMID:24172227
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
oleandrin results in increased expression of CXCR4 mRNA
CTD
PMID:24172227
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19917
chemical entity
19915
molecular entity
19915
polyatomic entity
19868
heteroatomic molecular entity
19826
hydroxides
19379
organic hydroxy compound
18986
hydroxy steroid
14469
16-hydroxy steroid
158
16beta-hydroxy steroid
9
gitoxigenin
5
(1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol
0
Abikoviromycin
0
Awajanomycin
0
Batrachotoxinin A
0
Kobutimycin A
0
Kobutimycin B
0
LSM-1903
0
Latumcidin
0
Nocarditriene
0
digitalin
0
gitoxigenin 3-acetate
0
gitoxin +
0
oleandrigenin +
5
strospeside
0
Path 2
CHEBI ontology
19917
subatomic particle
19915
composite particle
19915
hadron
19915
baryon
19915
nucleon
19915
atomic nucleus
19915
atom
19915
main group element atom
19855
p-block element atom
19855
carbon group element atom
19794
carbon atom
19790
organic molecular entity
19790
heteroorganic entity
19548
organochalcogen compound
19307
organooxygen compound
19223
ester
17478
carboxylic ester
16760
lactone
13302
steroid lactone
475
cardanolide
49
5beta-cardanolide
49
gitoxigenin
5
(1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol
0
Abikoviromycin
0
Awajanomycin
0
Batrachotoxinin A
0
Kobutimycin A
0
Kobutimycin B
0
LSM-1903
0
Latumcidin
0
Nocarditriene
0
digitalin
0
gitoxigenin 3-acetate
0
gitoxin +
0
oleandrigenin +
5
strospeside
0