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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gitoxigenin
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Accession:CHEBI:38105 term browser browse the term
Definition:A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms:exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
 related_synonym: 16beta-Hydroxydigitoxigenin;   Formula=C23H34O5;   InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1;   InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: Beilstein:96483;   CAS:545-26-6



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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      molecular entity 19915
        polyatomic entity 19868
          heteroatomic molecular entity 19826
            hydroxides 19379
              organic hydroxy compound 18986
                hydroxy steroid 14469
                  16-hydroxy steroid 158
                    16beta-hydroxy steroid 9
                      gitoxigenin 5
                        (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                        Abikoviromycin 0
                        Awajanomycin 0
                        Batrachotoxinin A 0
                        Kobutimycin A 0
                        Kobutimycin B 0
                        LSM-1903 0
                        Latumcidin 0
                        Nocarditriene 0
                        digitalin 0
                        gitoxigenin 3-acetate 0
                        gitoxin + 0
                        oleandrigenin + 5
                        strospeside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19548
                              organochalcogen compound 19307
                                organooxygen compound 19223
                                  ester 17478
                                    carboxylic ester 16760
                                      lactone 13302
                                        steroid lactone 475
                                          cardanolide 49
                                            5beta-cardanolide 49
                                              gitoxigenin 5
                                                (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                                                Abikoviromycin 0
                                                Awajanomycin 0
                                                Batrachotoxinin A 0
                                                Kobutimycin A 0
                                                Kobutimycin B 0
                                                LSM-1903 0
                                                Latumcidin 0
                                                Nocarditriene 0
                                                digitalin 0
                                                gitoxigenin 3-acetate 0
                                                gitoxin + 0
                                                oleandrigenin + 5
                                                strospeside 0
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