Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-benzofuran-1(3H)-one
go back to main search page
Accession:CHEBI:38085 term browser browse the term
Definition:A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
Synonyms:related_synonym: 1(3H)-isobenzofuranone;   1-Phthalanone;   2-Hydroxymethylbenzoic acid, gamma-lactone;   3-oxo-1,3-dihydro-isobenzofuran;   Formula=C8H6O2;   InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2;   InChIKey=WNZQDUSMALZDQF-UHFFFAOYSA-N;   Phthalolactone;   SMILES=O=C1OCc2ccccc12;   isobenzofuranone;   phthalide
 xref: CAS:87-41-2;   HMDB:HMDB0032469;   PMID:23462848;   Reaxys:114632;   Wikipedia:Phthalide


show annotations for term's descendants           Sort by:
(Z)-3-butylidenephthalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP
ISO		 butylidenephthalide results in increased expression of AIFM1 protein CTD PMID:16987298 PMID:23770345 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Anxa5 annexin A5 decreases expression ISO butylidenephthalide results in decreased expression of ANXA5 protein CTD PMID:23770345 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO butylidenephthalide results in increased expression of ARHGAP1 protein CTD PMID:23770345 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO butylidenephthalide results in increased expression of ARHGDIA protein CTD PMID:23770345 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO butylidenephthalide results in increased expression of ATP5F1A protein CTD PMID:23770345 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO butylidenephthalide results in decreased expression of ATP5F1B protein CTD PMID:23770345 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP
ISO		 butylidenephthalide results in increased expression of BAX protein CTD PMID:16987298 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO butylidenephthalide results in increased expression of BIK protein CTD PMID:23770345 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G C1qbp complement C1q binding protein increases expression ISO butylidenephthalide results in increased expression of C1QBP protein CTD PMID:23770345 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Calr calreticulin decreases expression ISO butylidenephthalide results in decreased expression of CALR protein CTD PMID:23770345 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO
EXP		 butylidenephthalide results in increased cleavage of CASP3 protein CTD PMID:16987298 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO
EXP		 butylidenephthalide results in increased cleavage of CASP8 protein CTD PMID:16987298 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP
ISO		 butylidenephthalide results in increased cleavage of CASP9 protein CTD PMID:16987298 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO		 butylidenephthalide results in decreased expression of CCND1 protein CTD PMID:16987298 PMID:23770345 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO
EXP		 butylidenephthalide results in decreased expression of CCNE1 protein CTD PMID:16987298 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP
ISO		 butylidenephthalide results in decreased expression of CDK2 protein CTD PMID:16987298 PMID:23770345 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP
ISO		 butylidenephthalide results in decreased expression of CDK4 protein CTD PMID:16987298 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression EXP
ISO		 butylidenephthalide results in decreased expression of CDK6 protein CTD PMID:16987298 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 EXP
ISO		 butylidenephthalide results in decreased expression of CDKN1A protein
butylidenephthalide results in increased expression of CDKN1A protein		 CTD PMID:16987298 PMID:23770345 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP butylidenephthalide results in increased expression of CDKN1B protein CTD PMID:16987298 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO butylidenephthalide results in increased expression of CDKN2A protein CTD PMID:16987298 PMID:23770345 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO butylidenephthalide results in increased expression of CYCS protein CTD PMID:23770345 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
butylidenephthalide results in increased expression of CYP1A1 mRNA		 CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO butylidenephthalide results in increased expression of DDIT3 protein CTD PMID:23770345 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A1 protein CTD PMID:23770345 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A2 protein CTD PMID:23770345 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO butylidenephthalide results in increased expression of EEF2 protein CTD PMID:23770345 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 decreases expression ISO butylidenephthalide results in decreased expression of EIF4A1 protein CTD PMID:23770345 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of ELAVL1 protein CTD PMID:23770345 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Eno1 enolase 1 decreases expression ISO butylidenephthalide results in decreased expression of ENO1 protein CTD PMID:23770345 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO butylidenephthalide results in increased expression of ERN1 protein CTD PMID:23770345 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO butylidenephthalide results in increased expression of FAS protein CTD PMID:16987298 PMID:23770345 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fus Fus RNA binding protein increases expression ISO butylidenephthalide results in increased expression of FUS protein CTD PMID:23770345 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO butylidenephthalide results in increased expression of GOT1 protein CTD PMID:23770345 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO butylidenephthalide results in decreased expression of HNRNPA3 protein CTD PMID:23770345 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D increases expression ISO butylidenephthalide results in increased expression of HNRNPD protein CTD PMID:23770345 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO butylidenephthalide results in decreased expression of HNRNPF protein CTD PMID:23770345 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO butylidenephthalide results in decreased expression of HSP90AB1 protein CTD PMID:23770345 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO butylidenephthalide results in increased expression of HSPA5 protein CTD PMID:23770345 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO butylidenephthalide results in decreased expression of LDHA protein CTD PMID:23770345 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO butylidenephthalide results in increased expression of MIF protein CTD PMID:23770345 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO
EXP		 butylidenephthalide results in decreased expression of MKI67 protein CTD PMID:16987298 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Ncl nucleolin decreases expression ISO butylidenephthalide results in decreased expression of NCL protein CTD PMID:23770345 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO butylidenephthalide results in increased expression of NME1 protein CTD PMID:23770345 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO butylidenephthalide results in decreased expression of PCNA protein CTD PMID:23770345 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression ISO butylidenephthalide results in decreased expression of PGK1 protein CTD PMID:23770345 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Phb1 prohibitin 1 decreases expression ISO butylidenephthalide results in decreased expression of PHB1 protein CTD PMID:23770345 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO butylidenephthalide results in increased expression of PPP2R1A protein CTD PMID:23770345 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 decreases expression ISO butylidenephthalide results in decreased expression of PRPS1 protein CTD PMID:23770345 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187 		JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression ISO butylidenephthalide results in increased expression of PSMA1 protein CTD PMID:23770345 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 decreases expression ISO butylidenephthalide results in decreased expression of PSMD11 protein CTD PMID:23770345 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO
EXP		 butylidenephthalide results in decreased phosphorylation of RB1 protein CTD PMID:16987298 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rpsa ribosomal protein SA decreases expression ISO butylidenephthalide results in decreased expression of RPSA protein CTD PMID:23770345 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 increases expression ISO butylidenephthalide results in increased expression of SF3B3 protein CTD PMID:23770345 NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245 		JBrowse link
G Sfn stratifin increases expression ISO butylidenephthalide results in increased expression of SFN protein CTD PMID:23770345 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation		 ISO butylidenephthalide results in increased expression of TP53 protein
butylidenephthalide results in increased phosphorylation of TP53 protein		 CTD PMID:16987298 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO butylidenephthalide results in decreased expression of TPT1 protein CTD PMID:23770345 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO butylidenephthalide results in increased expression of TUFM protein CTD PMID:23770345 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G Was WASP actin nucleation promoting factor decreases expression ISO butylidenephthalide results in decreased expression of WAS protein CTD PMID:23770345 NCBI chr  X:14,405,105...14,413,850
Ensembl chr  X:14,405,124...14,413,849 		JBrowse link
G Ybx1 Y box binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of YBX1 protein CTD PMID:23770345 NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 affects transport EXP ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Cck cholecystokinin multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects binding		 ISO
EXP		 Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein
Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein binds to GSTA1 protein		 CTD PMID:3783048 PMID:9826190 PMID:15147239 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions
decreases activity		 EXP Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein results in decreased activity of GSTA3 protein		 CTD PMID:3783048 PMID:8968379 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases glutathionylation
decreases transport		 ISO KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein		 CTD PMID:19246623 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects abundance
increases transport
increases glutathionylation		 ISO NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein		 CTD PMID:19246623 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein		 CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] CTD PMID:16079298 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity		 ISO
EXP		 Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 PMID:18174275 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import
increases import
increases response to substance
increases uptake
multiple interactions		 ISO SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]		 CTD PMID:16046661 PMID:17369605 PMID:20171238 PMID:21430235 PMID:21661758 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases activity
increases uptake
affects import
multiple interactions		 ISO Sulfobromophthalein results in decreased activity of SLCO2B1 protein
SLCO2B1 protein results in increased uptake of Sulfobromophthalein
SLCO2B1 protein affects the import of Sulfobromophthalein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]		 CTD PMID:16046661 PMID:21430235 PMID:23121773 PMID:25106415 PMID:27450509 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
phenolphthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions		 ISO Phenolphthalein results in decreased activity of AKR1C1 protein
Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]		 CTD PMID:12604236 PMID:23933386 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Phenolphthalein results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions		 ISO Phenolphthalein results in decreased activity of AKR1C3 protein
Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]		 CTD PMID:12604236 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity		 ISO Phenolphthalein binds to ESR1 protein
Phenolphthalein binds to and results in decreased activity of ESR1 protein
Phenolphthalein results in increased activity of ESR1 protein		 CTD PMID:12598185 PMID:25012808 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenolphthalein inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Phenolphthalein binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenolphthalein binds to and results in decreased activity of NR1I3 protein alternative form; Phenolphthalein binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phenolphthalein binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tyms thymidylate synthetase decreases activity ISO Phenolphthalein results in decreased activity of TYMS protein CTD PMID:21696158 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      group 19831
        inorganic group 19410
          oxo group 18914
            organic oxo compound 18914
              carbonyl compound 18914
                carboxylic ester 16743
                  lactone 13299
                    gamma-lactone 6855
                      2-benzofuran-1(3H)-one 93
                        (Z)-3-butylidene-7-hydroxyphthalide 0
                        (Z)-3-butylidenephthalide 61
                        4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                        4-farnesyl-3,5-dihydroxy-6-methylphthalide + 0
                        bromosulfophthalein 22
                        bromosulfophthalein sodium 0
                        phenolphthalein 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  ester 17458
                                    carboxylic ester 16743
                                      lactone 13299
                                        gamma-lactone 6855
                                          2-benzofuran-1(3H)-one 93
                                            (Z)-3-butylidene-7-hydroxyphthalide 0
                                            (Z)-3-butylidenephthalide 61
                                            4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                                            4-farnesyl-3,5-dihydroxy-6-methylphthalide + 0
                                            bromosulfophthalein 22
                                            bromosulfophthalein sodium 0
                                            phenolphthalein 10
paths to the root