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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinolizines
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Accession:CHEBI:38063 term browser browse the term


show annotations for term's descendants           Sort by:
dolasetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO dolasetron results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
serpentine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions		 ISO serpentine (alkaloid) results in decreased activity of CYP2D6 protein
serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]		 CTD PMID:15930738 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
sparteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Sparteine results in decreased expression of CHRM1 mRNA; Sparteine results in decreased expression of CHRM1 protein CTD PMID:16843632 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP Sparteine results in decreased expression of CHRM2 mRNA; Sparteine results in decreased expression of CHRM2 protein CTD PMID:16843632 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression EXP Sparteine results in decreased expression of CHRM3 mRNA CTD PMID:16843632 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases expression EXP Sparteine results in increased expression of CHRM4 mRNA CTD PMID:16843632 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Sparteine CTD PMID:11907490 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Rest RE1-silencing transcription factor increases expression EXP Sparteine results in increased expression of REST mRNA CTD PMID:16843632 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Sparteine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          nitrogen atom 18974
            nitrogen molecular entity 18974
              organonitrogen compound 18827
                organonitrogen heterocyclic compound 18148
                  quinolizines 10
                    4,5-dimethylcyclopenta[c]quinolizine-1,2-dicarboxylic acid dimethyl ester 0
                    6-methyl-4-oxoquinolizine-1,3-dicarboxylic acid diethyl ester 0
                    Cadiamine 0
                    Clavepictine B 0
                    Collacyclumine D 0
                    Deoxynupharidine 0
                    Lamprolobine 0
                    Leontiformine 0
                    Myrtine 0
                    Nuphleine 0
                    Thiobinupharidine 0
                    dihydroserpentine(1+) 0
                    dolasetron + 1
                    quinolizidines + 7
                    quinolizine + 0
                    quinolizinium 0
                    serpentine 1
                    tiquizium + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      quinolizines 10
                                        4,5-dimethylcyclopenta[c]quinolizine-1,2-dicarboxylic acid dimethyl ester 0
                                        6-methyl-4-oxoquinolizine-1,3-dicarboxylic acid diethyl ester 0
                                        Cadiamine 0
                                        Clavepictine B 0
                                        Collacyclumine D 0
                                        Deoxynupharidine 0
                                        Lamprolobine 0
                                        Leontiformine 0
                                        Myrtine 0
                                        Nuphleine 0
                                        Thiobinupharidine 0
                                        dihydroserpentine(1+) 0
                                        dolasetron + 1
                                        quinolizidines + 7
                                        quinolizine + 0
                                        quinolizinium 0
                                        serpentine 1
                                        tiquizium + 3
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