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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminonaphthalene
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Accession:CHEBI:38034 term browser browse the term
Synonyms:related_synonym: aminonaphthalenes


show annotations for term's descendants           Sort by:
1-naphthylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1-Naphthylamine binds to and results in increased activity of AHR protein CTD PMID:11790108 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 1-Naphthylamine results in decreased expression of CYP17A1 mRNA CTD PMID:31100596 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 1-Naphthylamine results in increased expression of CYP19A1 mRNA CTD PMID:31100596 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fam83b family with sequence similarity 83, member B affects response to substance ISO FAM83B gene SNP affects the susceptibility to 1-Naphthylamine CTD PMID:25622337 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795 		JBrowse link
G Npas3 neuronal PAS domain protein 3 affects response to substance ISO NPAS3 gene SNP affects the susceptibility to 1-Naphthylamine CTD PMID:25622337 NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884 		JBrowse link
G Tmem132d transmembrane protein 132D affects response to substance ISO TMEM132D gene SNP affects the susceptibility to 1-Naphthylamine CTD PMID:25622337 NCBI chr12:28,270,039...28,917,324
Ensembl chr12:28,270,712...28,915,374 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO 1-Naphthylamine results in decreased activity of UGT1A9 protein CTD PMID:14744740 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
2-naphthylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatk apoptosis-associated tyrosine kinase increases expression ISO 2-Naphthylamine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112 		JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO 2-Naphthylamine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO 2-Naphthylamine results in decreased expression of BAD mRNA CTD PMID:18247414 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 2-Naphthylamine results in increased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO 2-Naphthylamine results in decreased expression of BRCA1 mRNA CTD PMID:18247414 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO 2-Naphthylamine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879 		JBrowse link
G Btk Bruton tyrosine kinase increases expression ISO 2-Naphthylamine results in increased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO 2-Naphthylamine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Cartpt CART prepropeptide increases expression ISO 2-Naphthylamine results in increased expression of CARTPT mRNA CTD PMID:18247414 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO 2-Naphthylamine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 2-Naphthylamine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO 2-Naphthylamine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO 2-Naphthylamine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cd4 Cd4 molecule increases expression ISO 2-Naphthylamine results in increased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191 		JBrowse link
G Cd59b CD59b molecule increases expression ISO 2-Naphthylamine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO 2-Naphthylamine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO 2-Naphthylamine results in decreased expression of CREB1 mRNA CTD PMID:18247414 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO 2-Naphthylamine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO 2-Naphthylamine results in decreased expression of CXCR2 mRNA CTD PMID:18247414 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO 2-Naphthylamine results in increased expression of CYP1A1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Naphthylamine results in increased expression of CYP1A1 mRNA]		 CTD PMID:25224404 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO CYP1A2 protein results in increased activity of 2-Naphthylamine CTD PMID:15450435 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 increases reduction ISO CYP2S1 protein results in increased reduction of 2-Naphthylamine analog CTD PMID:23682735 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases metabolic processing ISO
EXP		 CYP4B1 protein results in increased metabolism of 2-Naphthylamine CTD PMID:9310344 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Dedd death effector domain-containing increases expression ISO 2-Naphthylamine results in increased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332 		JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO 2-Naphthylamine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO 2-Naphthylamine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Ednra endothelin receptor type A decreases expression ISO 2-Naphthylamine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Enpep glutamyl aminopeptidase increases metabolic processing ISO
EXP		 ENPEP protein results in increased metabolism of 2-Naphthylamine analog CTD PMID:11732752 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO 2-Naphthylamine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Ephb3 Eph receptor B3 increases expression ISO 2-Naphthylamine results in increased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Epo erythropoietin increases expression ISO 2-Naphthylamine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ezr ezrin increases expression ISO 2-Naphthylamine results in increased expression of EZR mRNA CTD PMID:18247414 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Faslg Fas ligand decreases expression ISO 2-Naphthylamine results in decreased expression of FASLG mRNA CTD PMID:18247414 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO 2-Naphthylamine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO 2-Naphthylamine results in decreased expression of FN1 mRNA CTD PMID:18247414 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO 2-Naphthylamine results in increased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO 2-Naphthylamine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,097,314...19,112,519 		JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO 2-Naphthylamine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO NAT2 polymorphism affects the reaction [2-Naphthylamine results in increased mutagenesis of HPRT1 gene] CTD PMID:36040704 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO 2-Naphthylamine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Il10 interleukin 10 decreases expression ISO 2-Naphthylamine results in decreased expression of IL10 mRNA CTD PMID:18247414 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO 2-Naphthylamine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484 		JBrowse link
G Il9 interleukin 9 decreases expression ISO 2-Naphthylamine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO 2-Naphthylamine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Klf11 KLF transcription factor 11 increases expression ISO 2-Naphthylamine results in increased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase increases metabolic processing ISO
EXP		 LNPEP protein results in increased metabolism of 2-Naphthylamine analog CTD PMID:11732752 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Ltb lymphotoxin beta decreases expression ISO 2-Naphthylamine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO 2-Naphthylamine results in increased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of 2-Naphthylamine CTD PMID:9288889 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO 2-Naphthylamine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416 		JBrowse link
G Nat1 N-acetyltransferase 1 increases activity ISO NAT1 protein results in increased activity of 2-Naphthylamine CTD PMID:15450435 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 increases activity
affects acetylation
multiple interactions
increases acetylation		 ISO NAT2 protein results in increased activity of 2-Naphthylamine
NAT2 protein polymorphism affects the acetylation of 2-Naphthylamine
NAT2 polymorphism affects the reaction [2-Naphthylamine results in increased mutagenesis of HPRT1 gene]
NAT2 protein results in increased acetylation of 2-Naphthylamine		 CTD PMID:15450435 PMID:36040704 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO 2-Naphthylamine results in decreased expression of NFKBIE mRNA CTD PMID:18247414 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO 2-Naphthylamine results in decreased expression of NFYB mRNA CTD PMID:18247414 NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO 2-Naphthylamine results in decreased expression of NHERF2 mRNA CTD PMID:18247414 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO 2-Naphthylamine results in decreased expression of NME3 mRNA CTD PMID:18247414 NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 2-Naphthylamine results in increased expression of NOS2 mRNA CTD PMID:18247414 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 multiple interactions
affects binding		 ISO 2-Naphthylamine analog binds to and results in decreased activity of NPY5R protein
2-Naphthylamine analog binds to NPY5R protein		 CTD PMID:10937714 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO 2-Naphthylamine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Pld1 phospholipase D1 decreases expression ISO 2-Naphthylamine results in decreased expression of PLD1 mRNA CTD PMID:18247414 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 increases expression ISO 2-Naphthylamine results in increased expression of PLD2 mRNA CTD PMID:18247414 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO 2-Naphthylamine results in decreased expression of POU2AF1 mRNA CTD PMID:18247414 NCBI chr 8:51,521,813...51,548,819
Ensembl chr 8:51,474,015...51,548,819 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO 2-Naphthylamine results in increased expression of POU2F1 mRNA CTD PMID:18247414 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO 2-Naphthylamine results in increased expression of PRKAR2B mRNA CTD PMID:18247414 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO 2-Naphthylamine results in decreased expression of PSMB6 mRNA CTD PMID:18247414 NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Ptafr platelet-activating factor receptor decreases expression ISO 2-Naphthylamine results in decreased expression of PTAFR mRNA CTD PMID:18247414 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptx3 pentraxin 3 decreases expression ISO 2-Naphthylamine results in decreased expression of PTX3 mRNA CTD PMID:18247414 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression ISO 2-Naphthylamine results in decreased expression of RARG mRNA CTD PMID:18247414 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO 2-Naphthylamine results in increased expression of RGS1 mRNA CTD PMID:18247414 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rnpep arginyl aminopeptidase increases metabolic processing EXP
ISO		 RNPEP protein results in increased metabolism of 2-Naphthylamine analog CTD PMID:11732752 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO 2-Naphthylamine results in decreased expression of RPL7A mRNA CTD PMID:18247414 NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716
Ensembl chr18:10,239,001...10,241,716 		JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO 2-Naphthylamine results in increased expression of RPS25 mRNA CTD PMID:18247414 NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271 		JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO 2-Naphthylamine results in decreased expression of RUNX1T1 mRNA CTD PMID:18247414 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592 		JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO 2-Naphthylamine results in increased expression of S100A10 mRNA CTD PMID:18247414 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
G Smad9 SMAD family member 9 increases expression ISO 2-Naphthylamine results in increased expression of SMAD9 mRNA CTD PMID:18247414 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307 		JBrowse link
G Snca synuclein alpha increases expression ISO 2-Naphthylamine results in increased expression of SNCA mRNA CTD PMID:18247414 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO 2-Naphthylamine results in decreased expression of SREBF1 mRNA CTD PMID:18247414 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO 2-Naphthylamine results in decreased expression of STAT2 mRNA CTD PMID:18247414 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Stk25 serine/threonine kinase 25 increases expression ISO 2-Naphthylamine results in increased expression of STK25 mRNA CTD PMID:18247414 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of 2-Naphthylamine CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases sulfation ISO SULT1C2 protein results in increased sulfation of 2-Naphthylamine CTD PMID:17433394 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of 2-Naphthylamine CTD PMID:12039030 NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085 		JBrowse link
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit increases expression ISO 2-Naphthylamine results in increased expression of SUPT4H1 mRNA CTD PMID:18247414 NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831 		JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO 2-Naphthylamine results in decreased expression of TFDP1 mRNA CTD PMID:18247414 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO 2-Naphthylamine results in decreased expression of TNFRSF1A mRNA CTD PMID:18247414 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO 2-Naphthylamine results in decreased expression of TP53 mRNA CTD PMID:18247414 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression ISO 2-Naphthylamine results in increased expression of TSHR mRNA CTD PMID:18247414 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO 2-Naphthylamine results in increased expression of UBE2I mRNA CTD PMID:18247414 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO 2-Naphthylamine results in increased expression of UGP2 mRNA CTD PMID:18247414 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression ISO 2-Naphthylamine results in decreased expression of UQCRFS1 mRNA CTD PMID:18247414 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
G Vim vimentin decreases expression ISO 2-Naphthylamine results in decreased expression of VIM mRNA CTD PMID:18247414 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
2-propionyl-6-dimethylaminonaphthalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding		 ISO Guanidine inhibits the reaction [prodan binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein] CTD PMID:12044178 PMID:15328891 PMID:15353599 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
7-amino-4-hydroxy-2-naphthalenesulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO 7-amino-4-hydroxy-2-naphthalenesulfonic acid affects the activity of TP53 protein; 7-amino-4-hydroxy-2-naphthalenesulfonic acid metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
8-anilinonaphthalene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor affects binding ISO 1-anilino-8-naphthalenesulfonate binds to AMBP protein CTD PMID:16461020 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Apod apolipoprotein D affects binding ISO 1-anilino-8-naphthalenesulfonate binds to APOD protein CTD PMID:16461020 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G C8g complement C8 gamma chain affects binding ISO 1-anilino-8-naphthalenesulfonate binds to C8G protein CTD PMID:16461020 NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to GSTA1 protein CTD PMID:14690442 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Lcn1 lipocalin 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN1 protein CTD PMID:16461020 NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577 		JBrowse link
G Lcn2 lipocalin 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN2 protein CTD PMID:16461020 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Obp2a odorant binding protein 2A affects binding ISO 1-anilino-8-naphthalenesulfonate binds to OBP2A protein CTD PMID:16461020 NCBI chr 3:8,505,963...8,509,269
Ensembl chr 3:8,505,990...8,509,269 		JBrowse link
G Orm1 orosomucoid 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to ORM1 protein CTD PMID:16461020 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Paep progestagen associated endometrial protein affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PAEP protein CTD PMID:16461020 NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430 		JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ttr transthyretin affects binding
multiple interactions		 ISO 1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]		 CTD PMID:23584369 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
cascade blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
increases uptake		 ISO Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
glycyl-L-phenylalanine 2-naphthylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 multiple interactions ISO 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]; NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
monodansylcadaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO monodansylcadaverine results in decreased phosphorylation of AKT1 protein CTD PMID:16170020 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO monodansylcadaverine results in decreased expression of BAD protein CTD PMID:16170020 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO monodansylcadaverine results in increased expression of BCL2L11 protein CTD PMID:16170020 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO monodansylcadaverine results in decreased expression of BIRC5 protein CTD PMID:16170020 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO monodansylcadaverine results in decreased expression of GSK3B protein CTD PMID:16170020 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]; monodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:20733350 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO monodansylcadaverine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL12B protein] CTD PMID:22341560 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein] CTD PMID:22341560 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:22341560 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein] CTD PMID:22341560 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:22341560 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:22341560 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:22341560 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein] CTD PMID:22341560 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Tgm2 transglutaminase 2 decreases activity ISO monodansylcadaverine results in decreased activity of TGM2 protein CTD PMID:16382148 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein] CTD PMID:22341560 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP4 protein] CTD PMID:22341560 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          ammonia 17865
            organic amino compound 17865
              aromatic amine 15478
                aminonaphthalene 135
                  2-acyl-6-dimethylaminonaphthalene + 1
                  4-amino-3-hydroxynaphthalene-1-sulfonic acid 0
                  6-amino-1,2-dihydroxynaphthalene 0
                  6-dimethylamino-2-naphthoic acid + 0
                  8-Phenylamino-naphthalene-1-sulfonic acid anion 0
                  8-anilinonaphthalene-1-sulfonic acid 11
                  Evans blue free acid 0
                  HA15 0
                  aminonaphthalenesulfonic acid + 1
                  cascade blue 1
                  dansyl chloride + 0
                  monodansylcadaverine 26
                  naphthylamine + 99
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          aminonaphthalene 135
                                            2-acyl-6-dimethylaminonaphthalene + 1
                                            4-amino-3-hydroxynaphthalene-1-sulfonic acid 0
                                            6-amino-1,2-dihydroxynaphthalene 0
                                            6-dimethylamino-2-naphthoic acid + 0
                                            8-Phenylamino-naphthalene-1-sulfonic acid anion 0
                                            8-anilinonaphthalene-1-sulfonic acid 11
                                            Evans blue free acid 0
                                            HA15 0
                                            aminonaphthalenesulfonic acid + 1
                                            cascade blue 1
                                            dansyl chloride + 0
                                            monodansylcadaverine 26
                                            naphthylamine + 99
paths to the root