histamine antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	histamine antagonist	go back to main search page
Accession:	CHEBI:37956	browse the term
Definition:	Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
Synonyms:	related_synonym:	antihistamine; antihistamines; antihistaminico; antihistaminics; histamine receptor blocker; histamine receptor blockers
	xref:	pubmed:22035879; wikipedia.en:Antihistamines

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Rat (4935 ) Mouse (4890 ) Human (5255 ) Chinchilla (0 ) Bonobo (0 ) Dog (7 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (4935)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

acrivastine results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

ISO

Antazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

trace-amine-associated receptor 1

increases activity
multiple interactions

ISO

Antazoline results in increased activity of TAAR1 protein
[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase, long chain

decreases expression

EXP

Aripiprazole results in decreased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

adenosine A2a receptor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

actin related protein 2/3 complex, subunit 1B

decreases expression

EXP

Aripiprazole results in decreased expression of ARPC1B mRNA

NCBI chr12:14,595,939...14,609,501
Ensembl chr12:14,595,678...14,609,504

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Aripiprazole results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL10, immune signaling adaptor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of BCL10 mRNA

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:237,501,134...237,511,829

G

Bcl2-like 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

BCL6, transcription repressor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BH3 interacting domain death agonist

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

complement C1r

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in decreased expression of C1R mRNA]

NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714

G

complement C2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of C2 mRNA

NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,955,776...3,981,740

G

caspase 3

increases expression

ISO

Aripiprazole results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

chromobox 7

decreases expression
increases expression

EXP

Aripiprazole results in decreased expression of CBX7 mRNA
Aripiprazole results in increased expression of CBX7 mRNA

NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:113,341,030...113,358,346

G

C-C motif chemokine ligand 19

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL19 mRNA

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022

G

C-C motif chemokine ligand 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 22

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in increased expression of CCL22 mRNA]

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine receptor 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CCR3 mRNA

NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593

G

CD274 molecule

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CD274 mRNA

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD33 molecule

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CD33 mRNA

NCBI chr 1:103,071,985...103,086,687
Ensembl chr 1:103,072,375...103,086,291

G

CD44 molecule

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd70 molecule

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CD70 mRNA

NCBI chr 9:2,093,540...2,096,692
Ensembl chr 9:2,086,848...2,096,692

G

CD83 molecule

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

cadherin 5

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in increased expression of CDH5 mRNA]

NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CCAAT/enhancer binding protein beta

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

carboxylesterase 1D

multiple interactions

ISO

Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

complement factor B

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

claudin 5

decreases expression

EXP

Aripiprazole results in decreased expression of CLDN5 mRNA

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

cannabinoid receptor 1

increases expression

EXP

Aripiprazole results in increased expression of CNR1 mRNA

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

catechol-O-methyltransferase

increases expression

EXP

Aripiprazole results in increased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

cAMP responsive element binding protein 1

increases expression

EXP

Aripiprazole results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element binding protein 5

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CREB5 mRNA

NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793

G

CREB binding protein

decreases expression

EXP

Aripiprazole results in decreased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

collapsin response mediator protein 1

increases expression

EXP

Aripiprazole results in increased expression of CRMP1 mRNA

NCBI chr14:77,734,675...77,780,916
Ensembl chr14:77,734,675...77,780,916

G

colony stimulating factor 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CSF1 mRNA

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

C-X3-C motif chemokine ligand 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

C-X-C motif chemokine ligand 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 5

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CXCR5 mRNA

NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:53,740,197...53,754,816

G

C-X-C motif chemokine receptor 6

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CXCR6 mRNA

NCBI chr 8:132,311,834...132,317,001
Ensembl chr 8:132,306,600...132,322,498

G

cytochrome b-245 beta chain

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CYBB mRNA

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

CYLD lysine 63 deubiquitinase

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

doublecortin

decreases expression

ISO

Aripiprazole results in decreased expression of DCX mRNA

NCBI chr X:112,227,455...112,370,291
Ensembl chr X:112,227,455...112,304,161

G

discoidin domain receptor tyrosine kinase 2

decreases expression

EXP

Aripiprazole results in decreased expression of DDR2 mRNA

NCBI chr13:84,726,412...84,851,032
Ensembl chr13:84,731,180...84,850,288

G

DExD-box helicase 50

increases expression

EXP

Aripiprazole results in increased expression of DDX50 mRNA

NCBI chr20:31,104,354...31,133,652
Ensembl chr20:31,104,354...31,133,652

G

discs large MAGUK scaffold protein 4

decreases expression

ISO

Aripiprazole results in decreased expression of DLG4 mRNA

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839

G

dynein, axonemal, light chain 4

decreases expression

EXP

Aripiprazole results in decreased expression of DNAL4 mRNA

NCBI chr 7:113,192,807...113,205,665
Ensembl chr20:21,722,009...21,723,262
Ensembl chr 7:21,722,009...21,723,262

G

DNA methyltransferase 3 alpha

increases expression

EXP

Aripiprazole results in increased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dopamine receptor D2

multiple interactions

EXP
ISO

[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine

PMID:17069544 PMID:17327886

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dual specificity phosphatase 4

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of DUSP4 mRNA

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:64,079,893...64,093,700

G

dual specificity phosphatase 6

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

Epstein-Barr virus induced 3

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in increased expression of EBI3 mRNA]

NCBI chr 9:861,441...874,731
Ensembl chr 9:870,792...874,973

G

early growth response 1

increases expression

EXP

Aripiprazole results in increased expression of EGR1 mRNA; Aripiprazole results in increased expression of EGR1 protein

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

increases expression

EXP

Aripiprazole results in increased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 4

increases expression

EXP

Aripiprazole results in increased expression of EGR4 mRNA

NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368

G

elastase, neutrophil expressed

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ELANE mRNA

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725

G

ELAV like RNA binding protein 2

increases expression

EXP

Aripiprazole results in increased expression of ELAVL2 mRNA

NCBI chr 5:111,076,705...111,202,341
Ensembl chr 5:111,076,705...111,224,918

G

ETS proto-oncogene 1, transcription factor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

exocyst complex component 2

increases expression

EXP

Aripiprazole results in increased expression of EXOC2 mRNA

NCBI chr17:33,714,949...33,906,901
Ensembl chr17:33,715,008...33,901,944

G

F2R like trypsin receptor 1

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in increased expression of F2RL1 mRNA]

NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954

G

fasciculation and elongation protein zeta 1

multiple interactions
increases expression

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of FEZ1 mRNA
Aripiprazole results in increased expression of FEZ1 mRNA

NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:44,733,300...44,784,097

G

fibronectin 1

decreases expression

ISO

Aripiprazole results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

EXP

Aripiprazole results in increased expression of GABRB1 mRNA

NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,434,352...36,902,893

G

heparin-binding EGF-like growth factor

decreases expression

EXP

Aripiprazole results in decreased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

5-hydroxytryptamine receptor 1A

multiple interactions

ISO

Aripiprazole binds to and affects the activity of HTR1A protein; Aripiprazole binds to and results in increased activity of HTR1A protein

PMID:17069544 PMID:21823597

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 2A

multiple interactions
decreases response to substance
affects response to substance

ISO

Aripiprazole binds to and results in decreased activity of HTR2A protein; Aripiprazole binds to and results in increased activity of HTR2A protein; Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]
HTR2A gene SNP results in decreased susceptibility to Aripiprazole
HTR2A protein affects the susceptibility to Aripiprazole

PMID:16314884 PMID:21823597

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 2C

multiple interactions

ISO

Aripiprazole binds to and affects the activity of HTR2C protein

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

intercellular adhesion molecule 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

intercellular adhesion molecule 4, Landsteiner-Wiener blood group

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ICAM4 mRNA

NCBI chr 8:27,842,255...27,843,351
Ensembl chr 8:27,842,255...27,844,371

G

inducible T-cell co-stimulator ligand

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ICOSLG mRNA

NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,078...10,610,365

G

interferon beta 1

increases expression
multiple interactions

ISO

Aripiprazole results in increased expression of IFNB1 mRNA
Aripiprazole promotes the reaction [Ozone results in increased expression of IFNB1 mRNA]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IFNGR1 mRNA

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IKBKE mRNA

NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396

G

interleukin 11

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 1 alpha

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1R2 mRNA

NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374

G

interleukin 1 receptor accessory protein

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1RAP mRNA

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342

G

interleukin 1 receptor accessory protein-like 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1RAPL2 mRNA

NCBI chr X:105,547,403...107,080,369
Ensembl chr X:105,754,490...107,065,223

G

interleukin 1 receptor-like 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 23 subunit alpha

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL23A mRNA

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 24

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 2 receptor subunit gamma

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of IL2RG mRNA

NCBI chr X:70,435,340...70,439,052
Ensembl chr X:70,435,343...70,439,161

G

interleukin 4 receptor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL4R mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 5

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL5 mRNA

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL6 mRNA; Aripiprazole promotes the reaction [Ozone results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7 receptor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

inositol polyphosphate-5-phosphatase D

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of INPP5D mRNA

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

interleukin-1 receptor-associated kinase 2

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in increased expression of IRAK2 mRNA]

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

interferon regulatory factor 8

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of IRF8 mRNA

NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062

G

interferon stimulated exonuclease gene 20

increases expression
multiple interactions

ISO

Aripiprazole results in increased expression of ISG20 mRNA
[Aripiprazole co-treated with Ozone] results in increased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

integrin subunit alpha 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ITGA2 mRNA

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

integrin subunit alpha 5

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of ITGA5 mRNA

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

ISO

Aripiprazole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Aripiprazole results in decreased activity of KCNH2 protein

PMID:21158687 PMID:28551711

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium inwardly-rectifying channel, subfamily J, member 3

increases expression

EXP

Aripiprazole results in increased expression of KCNJ3 mRNA

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

LIF, interleukin 6 family cytokine

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

leucine rich repeat neuronal 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of LRRN3 mRNA

NCBI chr 6:64,216,164...64,247,293
Ensembl chr 6:64,215,878...64,247,614

G

lymphotoxin alpha

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of LTA mRNA

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533

G

lymphotoxin beta

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of LYN mRNA

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461

G

monoamine oxidase B

increases expression

EXP

Aripiprazole results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 2

decreases expression

ISO

Aripiprazole results in decreased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen-activated protein kinase 6

increases expression

EXP

Aripiprazole results in increased expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

MAPK activated protein kinase 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of MAPKAPK2 mRNA

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326

G

nestin

decreases expression

ISO

Aripiprazole results in decreased expression of NES mRNA

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

neuronal differentiation 1

decreases expression

ISO

Aripiprazole results in decreased expression of NEUROD1 mRNA

NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:84,764,725...84,770,810

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in increased expression of NFKB2 mRNA]

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nucleotide-binding oligomerization domain containing 2

multiple interactions
increases expression

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NOD2 mRNA
Aripiprazole results in increased expression of NOD2 mRNA

NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846

G

nitric oxide synthase 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NOS2A mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

neural proliferation, differentiation and control, 1

decreases expression

EXP

Aripiprazole results in decreased expression of NPDC1 mRNA

NCBI chr 3:28,618,601...28,624,591

G

5' nucleotidase, ecto

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

neurotrimin

decreases expression

EXP

Aripiprazole results in decreased expression of NTM mRNA

NCBI chr 8:35,634,929...36,625,081
Ensembl chr 8:35,635,640...36,624,807

G

oligodendrocyte transcription factor 2

decreases expression

ISO

Aripiprazole results in decreased expression of OLIG2 mRNA

NCBI chr11:43,961,585...43,964,961
Ensembl chr11:43,958,940...43,968,634

G

paired box 6

decreases expression

ISO

Aripiprazole results in decreased expression of PAX6 mRNA

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763

G

programmed cell death 1 ligand 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PDCD1LG2 mRNA

NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:236,565,526...236,637,490

G

platelet derived growth factor C

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of PDGFC mRNA

NCBI chr 2:168,613,409...168,791,575
Ensembl chr 2:168,614,353...168,791,573

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

EXP

Aripiprazole results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960

G

plasminogen activator, urokinase

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

POU class 2 homeobox 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of POU2F2 mRNA

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564

G

proteoglycan 2, pro eosinophil major basic protein

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PRG2 mRNA

NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752

G

protein kinase cAMP-activated catalytic subunit alpha

increases expression

EXP

Aripiprazole results in increased expression of PRKACA protein

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase C, delta

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

prolactin

multiple interactions
increases secretion
decreases secretion
decreases expression

ISO
EXP

Aripiprazole inhibits the reaction [haloperidol decanoate results in increased expression of PRL protein]; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]
Aripiprazole results in increased secretion of PRL protein
Aripiprazole results in decreased secretion of PRL protein
Aripiprazole inhibits the reaction [talipexole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]
Aripiprazole results in decreased expression of PRL protein

PMID:8613910 PMID:17873694 PMID:19230981 PMID:19519261 PMID:19653986 More...

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

proline dehydrogenase 1

decreases expression

EXP

Aripiprazole results in decreased expression of PRODH mRNA

NCBI chr11:96,414,275...96,431,604
Ensembl chr11:96,414,224...96,433,418

G

proteasome 26S subunit, ATPase 6

increases expression

EXP

Aripiprazole results in increased expression of PSMC6 mRNA

NCBI chr15:21,022,314...21,043,785
Ensembl chr15:21,022,314...21,043,785

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

PYD and CARD domain containing

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RAB3A, member RAS oncogene family

increases expression

EXP

Aripiprazole results in increased expression of RAB3A mRNA

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842

G

ras related dexamethasone induced 1

increases expression

EXP

Aripiprazole results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RNA binding fox-1 homolog 3

decreases expression

ISO

Aripiprazole results in decreased expression of RBFOX3 mRNA

NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

RNA sensor RIG-1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of RIGI mRNA

NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995

G

S100 calcium binding protein B

decreases expression

ISO

Aripiprazole results in decreased expression of S100B mRNA

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

SUMO1 activating enzyme subunit 1

increases expression

EXP

Aripiprazole results in increased expression of SAE1 mRNA

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:86,159,114...86,215,089

G

strawberry notch homolog 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of SBNO2 mRNA

NCBI chr 7:10,256,221...10,300,175
Ensembl chr 7:10,253,248...10,300,176

G

serpin family B member 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of SERPINB2 mRNA

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031

G

SH2B adaptor protein 2

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of SH2B2 mRNA

NCBI chr12:26,063,812...26,093,468
Ensembl chr12:26,064,486...26,093,467

G

SLAM family member 6

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of SLAMF6 mRNA

NCBI chr13:86,916,956...86,937,697
Ensembl chr13:86,916,122...86,938,354

G

solute carrier family 6 member 4

affects binding

ISO

Aripiprazole binds to SLC6A4 protein

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier organic anion transporter family, member 2b1

decreases expression

EXP

Aripiprazole results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279

G

slit guidance ligand 3

increases expression

EXP

Aripiprazole results in increased expression of SLIT3 mRNA

NCBI chr10:20,075,929...20,660,704
Ensembl chr10:20,076,021...20,660,704

G

SMAD family member 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

suppressor of cytokine signaling 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of SOCS1 mRNA

NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847

G

SRY-box transcription factor 2

decreases expression

ISO

Aripiprazole results in decreased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

synapsin I

decreases expression

ISO

Aripiprazole results in decreased expression of SYN1 mRNA

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938

G

synaptotagmin 17

decreases expression
multiple interactions

ISO

Aripiprazole results in decreased expression of SYT17 mRNA
[Aripiprazole co-treated with Ozone] results in decreased expression of SYT17 mRNA

NCBI chr 1:182,129,491...182,195,827
Ensembl chr 1:182,129,496...182,204,028

G

TGF-beta activated kinase 1/MAP3K7 binding protein 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of TAB1 mRNA

NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351

G

tachykinin receptor 3

decreases expression
increases expression

EXP

Aripiprazole results in decreased expression of TACR3 mRNA
Aripiprazole results in increased expression of TACR3 mRNA

NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:225,940,444...226,037,756

G

thrombomodulin

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

thrombospondin 1

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in increased expression of THBS1 mRNA]

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

TIR domain containing adaptor molecule 1

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TICAM1 mRNA

NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892

G

toll-like receptor 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of TLR3 mRNA

NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385

G

toll-like receptor 5

increases expression
multiple interactions

ISO

Aripiprazole results in increased expression of TLR5 mRNA
[Aripiprazole co-treated with Ozone] results in decreased expression of TLR5 mRNA

NCBI chr13:97,166,430...97,190,642
Ensembl chr13:97,166,405...97,192,525

G

tumor necrosis factor

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 11B

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in increased expression of TNFRSF11B mRNA]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 12A

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF receptor superfamily member 14

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of TNFRSF14 mRNA

NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:170,768,416...170,776,046

G

TNF receptor superfamily member 1B

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

tumor necrosis factor receptor superfamily, member 22

multiple interactions

ISO

Aripiprazole inhibits the reaction [Ozone results in decreased expression of TNFRSF10C mRNA]

NCBI chr 1:208,269,844...208,285,823
Ensembl chr 1:208,258,836...208,289,832

G

TNF receptor superfamily member 8

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF8 mRNA

NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620

G

TNF receptor superfamily member 9

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF9 mRNA

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831

G

TNF superfamily member 10

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 12

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF12 mRNA

NCBI chr10:54,902,616...54,912,628
Ensembl chr10:54,902,616...54,911,913

G

TNF superfamily member 15

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFSF15 mRNA

NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882

G

TNF superfamily member 18

multiple interactions

ISO

[Aripiprazole co-treated with Ozone] results in increased expression of TNFSF18 mRNA

NCBI chr13:76,366,790...76,440,673
Ensembl chr13:76,366,771...76,376,608

G

tubulin, beta 2A class IIa

decreases expression

EXP

Aripiprazole results in decreased expression of TUBB2A mRNA

NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,983,387...31,006,838

G

tubulin, beta 3 class III

decreases expression

ISO

Aripiprazole results in decreased expression of TUBB3 mRNA; Aripiprazole results in decreased expression of TUBB3 protein

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

vascular endothelial growth factor A

multiple interactions

ISO

Aripiprazole promotes the reaction [Ozone results in increased expression of VEGFA mRNA]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WEE1 G2 checkpoint kinase

increases expression

EXP

Aripiprazole results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

zinc finger protein 354C

increases expression

EXP

Aripiprazole results in increased expression of ZNF354C mRNA

NCBI chr10:35,630,738...35,647,176
Ensembl chr10:35,630,738...35,646,754

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Astemizole results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

adenylate kinase 3

increases expression

EXP

Astemizole results in increased expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

5'-aminolevulinate synthase 2

increases expression

EXP

Astemizole results in increased expression of ALAS2 mRNA

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:22,890,689...22,914,043

G

angiopoietin 2

increases expression

EXP

Astemizole results in increased expression of ANGPT2 mRNA

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:77,790,563...77,841,239

G

activating transcription factor 3

increases expression

ISO

Astemizole results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

EXP

Astemizole results in increased expression of ATP1B1 mRNA

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase Na+/K+ transporting subunit beta 2

decreases expression

EXP

Astemizole results in decreased expression of ATP1B2 mRNA

NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,817,476...54,823,708

G

ATP synthase F1 subunit epsilon

increases expression

EXP

Astemizole results in increased expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

BCL2, apoptosis regulator

decreases expression

EXP

Astemizole results in decreased expression of BCL2 mRNA

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone morphogenetic protein 1

decreases expression

EXP

Astemizole results in decreased expression of BMP1 mRNA

NCBI chr15:51,961,310...52,005,597
Ensembl chr15:51,961,310...52,005,485

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

EXP

Astemizole results in decreased expression of CAMK2D mRNA

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

catalase

increases expression

EXP

Astemizole results in increased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 7

decreases expression

EXP

Astemizole results in decreased expression of CCL7 mRNA

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

CCAAT/enhancer binding protein beta

increases expression

EXP

Astemizole results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein gamma

decreases expression

EXP

Astemizole results in decreased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

complement factor H

decreases expression

EXP

Astemizole results in decreased expression of CFH mRNA

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

collectin sub-family member 12

decreases expression

EXP

Astemizole results in decreased expression of COLEC12 mRNA

NCBI chr18:1,005,787...1,193,455
Ensembl chr18:1,005,741...1,195,297

G

cytochrome c oxidase subunit VIc, pseudogene

increases expression

EXP

Astemizole results in increased expression of COX6C-PS1 mRNA

NCBI chr19:69,090,047...69,090,905
Ensembl chr19:69,090,047...69,090,905

G

corticotropin releasing hormone

multiple interactions

EXP

Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

C-X-C motif chemokine ligand 3

decreases expression

EXP

Astemizole results in decreased expression of CXCL3 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 9

decreases expression

EXP

Astemizole results in decreased expression of CXCL9 mRNA

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions
affects metabolic processing
increases metabolic processing
decreases methylation

ISO

Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]
CYP2J2 polymorphism affects the metabolism of Astemizole
CYP2J2 protein results in increased metabolism of Astemizole

PMID:12386130 PMID:15861034 PMID:17162467 PMID:39643151

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases degradation

ISO

CYP3A4 protein results in increased degradation of Astemizole

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

ELL associated factor 1

increases expression

EXP

Astemizole results in increased expression of EAF1 mRNA

NCBI chr16:6,704,727...6,719,476
Ensembl chr16:6,704,727...6,719,476

G

egl-9 family hypoxia-inducible factor 1

increases expression

EXP

Astemizole results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681

G

eukaryotic translation initiation factor 4A1

increases expression

EXP

Astemizole results in increased expression of EIF4A1 mRNA

NCBI chr10:54,883,093...54,888,602
Ensembl chr10:54,883,093...54,888,602

G

ERBB receptor feedback inhibitor 1

decreases expression

EXP

Astemizole results in decreased expression of ERRFI1 mRNA

NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432

G

ETS variant transcription factor 5

decreases expression

EXP

Astemizole results in decreased expression of ETV5 mRNA

NCBI chr11:92,113,171...92,170,758
Ensembl chr11:92,113,224...92,170,767

G

family with sequence similarity 124 member A

increases expression

EXP

Astemizole results in increased expression of FAM124A mRNA

NCBI chr15:40,975,789...41,031,069
Ensembl chr15:40,975,877...41,029,628

G

Fc epsilon receptor Ia

multiple interactions

EXP

Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]

NCBI chr13:88,218,427...88,224,723
Ensembl chr13:88,218,420...88,224,681

G

growth differentiation factor 10

increases expression

EXP

Astemizole results in increased expression of GDF10 mRNA

NCBI chr16:9,243,434...9,256,788
Ensembl chr16:9,243,317...9,256,794

G

GTPase, IMAP family member 1

increases expression

EXP

Astemizole results in increased expression of GIMAP1 mRNA

NCBI chr 4:79,018,473...79,022,360
Ensembl chr 4:79,018,202...79,022,525

G

glycoprotein m6b

increases expression

EXP

Astemizole results in increased expression of GPM6B mRNA

NCBI chr X:31,689,485...31,836,199
Ensembl chr X:31,690,359...31,733,272

G

glutathione peroxidase 4

increases expression

EXP

Astemizole results in increased expression of GPX4 mRNA

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

hexosaminidase subunit beta

increases secretion
multiple interactions

EXP

Astemizole results in increased secretion of HEXB protein
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

heme oxygenase 1

increases expression

ISO

Astemizole results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

histamine receptor H 1

multiple interactions

ISO

[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

PMID:12147327 PMID:16129921

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

heat shock protein 90 alpha family class B member 1

decreases expression

EXP

Astemizole results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 8

increases expression

EXP

Astemizole results in increased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 8

increases expression

EXP

Astemizole results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

heat shock protein family H (Hsp110) member 1

decreases expression

EXP

Astemizole results in decreased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

intercellular adhesion molecule 1

multiple interactions

ISO

Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

EXP

Astemizole results in decreased expression of IFIT3 mRNA

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521

G

insulin-like growth factor 1

multiple interactions

ISO

Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

immunoglobulin superfamily, member 6

decreases expression

EXP

Astemizole results in decreased expression of IGSF6 mRNA

NCBI chr 1:185,041,462...185,051,956
Ensembl chr 1:185,041,462...185,052,245

G

interleukin 1 beta

multiple interactions

ISO

Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 36 receptor antagonist

increases expression

EXP

Astemizole results in increased expression of IL36RN mRNA

NCBI chr 3:27,442,679...27,449,306
Ensembl chr 3:27,442,709...27,449,306

G

interleukin 7 receptor

decreases expression

EXP

Astemizole results in decreased expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

integrin subunit alpha 8

increases expression

EXP

Astemizole results in increased expression of ITGA8 mRNA

NCBI chr17:80,213,139...80,410,633
Ensembl chr17:80,213,143...80,410,633

G

potassium voltage-gated channel subfamily H member 1

multiple interactions
decreases activity
affects binding

ISO

Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
Astemizole results in decreased activity of KCNH1 protein
Astemizole binds to KCNH1 protein

PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 More...

NCBI chr13:106,253,101...106,555,712
Ensembl chr13:106,253,213...106,555,710

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
affects binding
decreases activity
affects localization

ISO
EXP

Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]
Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein
Astemizole affects the localization of KCNH2 protein mutant form

PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 More...

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel subfamily Q member 2

multiple interactions

ISO

Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

NCBI chr 3:188,572,345...188,631,391
Ensembl chr 3:188,572,926...188,631,302

G

potassium voltage-gated channel subfamily Q member 3

multiple interactions

ISO

Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

NCBI chr 7:99,614,089...99,914,736
Ensembl chr 7:99,619,544...99,914,610

G

monoamine oxidase A

decreases expression

EXP

Astemizole results in decreased expression of MAOA mRNA

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

microtubule-associated protein tau

affects binding

ISO

Astemizole binds to MAPT protein alternative form

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

matrix metallopeptidase 2

decreases expression

EXP

Astemizole results in decreased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

membrane spanning 4-domains A6A

decreases expression

EXP

Astemizole results in decreased expression of MS4A6A mRNA

NCBI chr 1:217,826,261...217,839,606
Ensembl chr 1:217,826,261...217,850,013

G

metallothionein 2

increases expression

ISO

Astemizole results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metal-regulatory transcription factor 1

multiple interactions

ISO

MTF1 protein affects the reaction [Astemizole results in increased expression of MT1M mRNA]

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

microtubule associated scaffold protein 1

decreases expression

EXP

Astemizole results in decreased expression of MTUS1 mRNA

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474

G

myosin heavy chain 6

increases expression

EXP

Astemizole results in increased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

EXP

Astemizole results in increased expression of NDUFS7 mRNA

NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:10,103,227...10,110,691

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

EXP

Astemizole results in increased expression of NDUFV2 mRNA

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

N-terminal EF-hand calcium binding protein 1

decreases expression

EXP

Astemizole results in decreased expression of NECAB1 mRNA

NCBI chr 5:33,155,078...33,375,707
Ensembl chr 5:33,153,975...33,375,707

G

nuclear receptor subfamily 4, group A, member 3

increases expression

EXP

Astemizole results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

2'-5'-oligoadenylate synthetase-like

decreases expression

EXP

Astemizole results in decreased expression of OASL1 mRNA

NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483

G

oxysterol binding protein-like 3

increases expression

EXP

Astemizole results in increased expression of OSBPL3 mRNA

NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169

G

O-sialoglycoprotein endopeptidase-like 1

increases expression

EXP

Astemizole results in increased expression of OSGEPL1 mRNA

NCBI chr 9:55,707,389...55,725,325
Ensembl chr 9:55,707,392...55,721,346

G

Parkinsonism associated deglycase

increases expression

EXP

Astemizole results in increased expression of PARK7 mRNA

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

protocadherin 17

decreases expression

EXP

Astemizole results in decreased expression of PCDH17 mRNA

NCBI chr15:66,631,549...66,725,007
Ensembl chr15:66,633,142...66,722,105

G

pellino E3 ubiquitin protein ligase family member 2

increases expression

EXP

Astemizole results in increased expression of PELI2 mRNA

NCBI chr15:23,872,984...24,017,448
Ensembl chr15:23,872,984...24,014,817

G

prolactin family 8, subfamily A, member 3

decreases expression

EXP

Astemizole results in decreased expression of PRL8A3 mRNA

NCBI chr17:37,716,716...37,723,215

G

proteasome 20S subunit beta 5

increases expression

EXP

Astemizole results in increased expression of PSMB5 mRNA

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379

G

prostaglandin-endoperoxide synthase 1

decreases expression

EXP

Astemizole results in decreased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

pyrroline-5-carboxylate reductase 3

increases expression

EXP

Astemizole results in increased expression of PYCR3 mRNA

NCBI chr 7:109,484,263...109,489,554

G

glycogen phosphorylase, muscle associated

increases expression

EXP

Astemizole results in increased expression of PYGM mRNA

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:213,119,791...213,134,612

G

S100 calcium binding protein A8

increases expression

EXP

Astemizole results in increased expression of S100A8 mRNA

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

S100 calcium binding protein B

decreases expression

EXP

Astemizole results in decreased expression of S100B mRNA

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

salt-inducible kinase 1

decreases expression

EXP

Astemizole results in decreased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

solute carrier family 1 member 1

increases expression

EXP

Astemizole results in increased expression of SLC1A1 mRNA

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469

G

superoxide dismutase 2

increases expression

EXP

Astemizole results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sequestosome 1

increases expression

EXP

Astemizole results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

transferrin

decreases expression

EXP

Astemizole results in decreased expression of TF mRNA

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

transforming growth factor, beta 2

increases expression

EXP

Astemizole results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

toll-like receptor 2

decreases expression

EXP

Astemizole results in decreased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 7

decreases expression

EXP

Astemizole results in decreased expression of TLR7 mRNA

NCBI chr X:30,644,324...30,670,796
Ensembl chr X:30,644,355...30,672,151

G

tropomodulin 1

increases expression

EXP

Astemizole results in increased expression of TMOD1 mRNA

NCBI chr 5:65,112,062...65,189,563
Ensembl chr 5:65,134,132...65,189,561

G

vascular cell adhesion molecule 1

multiple interactions

ISO

Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

versican

decreases expression

EXP

Astemizole results in decreased expression of VCAN mRNA

NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H 1

multiple interactions

ISO

azatadine binds to and results in decreased activity of HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

ISO

azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
azelastine results in decreased activity of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetylcholinesterase

decreases activity

ISO

azelastine results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

collagen type I alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

collagen type VI alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107

G

histamine receptor H 1

affects binding

ISO

azelastine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

azelastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

azelastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

brompheniramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Brompheniramine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Brompheniramine results in decreased activity of KCNH2 protein

PMID:17010640 PMID:17516459

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

sodium voltage-gated channel alpha subunit 5

decreases activity

ISO

Brompheniramine results in decreased activity of SCN5A protein

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470

G

solute carrier family 22 member 2

multiple interactions

ISO

Brompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

buclizine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

carbinoxamine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

ISO

Cetirizine results in decreased expression of ABCB11 mRNA

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases export

ISO

ABCB1 protein results in increased export of Cetirizine

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

arachidonate 5-lipoxygenase

decreases activity

ISO

Cetirizine analog results in decreased activity of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

apolipoprotein E

multiple interactions
decreases expression

ISO

[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA; APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]; APOE protein results in decreased susceptibility to [Dietary Fats co-treated with Cetirizine]
Cetirizine results in decreased expression of APOE mRNA

PMID:24852568 PMID:25020133

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

creatine kinase, M-type

multiple interactions

ISO

[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

Cetirizine analog results in decreased activity of CYP3A4 protein; Cetirizine results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

hexosaminidase subunit beta

affects secretion

EXP

Cetirizine affects the secretion of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

histamine receptor H 1

multiple interactions
affects binding

ISO

Cetirizine binds to and results in decreased activity of HRH1 protein
Cetirizine analog binds to HRH1 protein; Cetirizine binds to HRH1 protein

PMID:15482930 PMID:16401869

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 4

decreases expression

ISO

Cetirizine results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

ISO

[montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

MLX interacting protein-like

decreases expression
multiple interactions

ISO

Cetirizine results in decreased expression of MLXIPL mRNA
APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]

NCBI chr12:27,178,158...27,213,675
Ensembl chr12:27,178,158...27,213,660

G

nitric oxide synthase 2

multiple interactions

ISO

[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

ISO

[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Chlorpheniramine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

butyrylcholinesterase

decreases activity

ISO

Chlorpheniramine results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases response to substance

ISO

CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

coagulation factor III, tissue factor

multiple interactions

ISO

Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

histamine receptor H 1

multiple interactions
decreases activity

ISO
EXP

Chlorpheniramine binds to and results in decreased activity of HRH1 protein
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]
Chlorpheniramine results in decreased activity of HRH1 protein

PMID:8111568 PMID:11432448 PMID:12128009 PMID:14569158 PMID:15054595 More...

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H 2

multiple interactions

ISO

Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041

G

heat shock transcription factor 1

decreases activity

ISO

Chlorpheniramine results in decreased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

interleukin 4

multiple interactions

EXP

Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

potassium voltage-gated channel subfamily H member 2

decreases activity
affects activity
multiple interactions

ISO

Chlorpheniramine results in decreased activity of KCNH2 protein
Chlorpheniramine affects the activity of KCNH2 protein
Chlorpheniramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:16278312 PMID:19885040 PMID:21158687

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

myeloperoxidase

decreases activity
multiple interactions

EXP

Chlorpheniramine results in decreased activity of MPO protein
Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Chlorpheniramine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 22 member 1

multiple interactions

EXP

Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

EXP
ISO

Chlorpheniramine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Chlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:12440152 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects transport
multiple interactions

ISO

ABCG2 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]

PMID:15365089 PMID:15722455 PMID:26907376

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

ISO

Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

multiple interactions

ISO

Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

ISO

Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

multiple interactions

ISO

Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]

NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:229,421,252...229,436,691

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

aryl hydrocarbon receptor

affects expression
multiple interactions

ISO

Cimetidine affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

ISO

Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

ISO

Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

apoptotic peptidase activating factor 1

increases activity

ISO

Cimetidine results in increased activity of APAF1 protein

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

androgen receptor

multiple interactions
decreases expression

ISO
EXP

Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein]
Cimetidine results in decreased expression of AR protein

PMID:6835285 PMID:26021711

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO

Cimetidine results in increased expression of BAX protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]

PMID:20127008 PMID:27983966

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO

Cimetidine results in decreased expression of BCL2 protein
Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]

PMID:20127008 PMID:27983966

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 1

increases activity
multiple interactions

ISO

Cimetidine results in increased activity of CASP1 protein
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

multiple interactions

ISO

Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein]

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases activity
multiple interactions
increases expression

ISO
EXP

Cimetidine results in increased activity of CASP3 protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
Cimetidine results in increased expression of CASP3 protein

PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity

ISO

Cimetidine results in increased activity of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases activity

ISO

Cimetidine results in increased activity of CASP8 protein

PMID:17273750 PMID:20127008

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

Cimetidine results in increased activity of CASP9 protein

PMID:17273750 PMID:20127008

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

CD14 molecule

decreases expression

ISO

Cimetidine results in decreased expression of CD14 protein

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

cystatin C

multiple interactions

ISO

Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3]

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

cathepsin D

decreases activity

EXP

Cimetidine results in decreased activity of CTSD protein

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin L

decreases activity

EXP

Cimetidine results in decreased activity of CTSL protein

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases expression
decreases activity

ISO

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]
Cimetidine results in decreased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein
Cimetidine results in decreased activity of CYP1A1 protein

PMID:11856816 PMID:22733800

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein]

PMID:7946932 PMID:19909766 PMID:31863871

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression
multiple interactions
decreases activity

ISO

Cimetidine results in decreased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein
Cimetidine results in decreased activity of CYP2B6 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

EXP

Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity
multiple interactions

ISO
EXP

Cimetidine results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]

PMID:17651725 PMID:19909766

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

ISO

Cimetidine results in decreased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

ISO

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression
decreases activity

ISO

[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
Cimetidine results in decreased expression of CYP3A4 protein

PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

multiple interactions

ISO

Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

epidermal growth factor receptor

multiple interactions

ISO

Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
[Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

follicle stimulating hormone subunit beta

affects expression

ISO

Cimetidine affects the expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

gastrin

affects expression

ISO

Cimetidine affects the expression of GAST protein

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

glutathione S-transferase pi 1

affects expression
multiple interactions

ISO

Cimetidine affects the expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

heme oxygenase 1

multiple interactions

EXP

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

histamine receptor H 1

multiple interactions

ISO

Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H 2

multiple interactions
decreases activity
increases expression

ISO
EXP

[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
Cimetidine results in decreased activity of HRH2 protein
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
Cimetidine results in increased expression of HRH2 protein

PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 More...

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

decreases expression

ISO

Cimetidine results in decreased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions
increases expression

ISO

Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 16

multiple interactions

ISO

Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 18

multiple interactions
increases expression

ISO

CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]
HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

integrin subunit alpha 4

decreases expression

ISO

Cimetidine results in decreased expression of ITGA4 protein

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha X

decreases expression

ISO

Cimetidine results in decreased expression of ITGAX protein

NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151

G

LDL receptor related protein 1

decreases expression

ISO

Cimetidine results in decreased expression of LRP1 protein

NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196

G

neural cell adhesion molecule 1

decreases expression

ISO

Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]

PMID:12065299 PMID:12107048

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear receptor subfamily 1, group I, member 2

decreases expression
multiple interactions

ISO

Cimetidine results in decreased expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

decreases expression
multiple interactions

ISO

Cimetidine results in decreased expression of NR1I3 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

neurotrophin 3

multiple interactions

EXP

Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

phosphodiesterase 4B

multiple interactions

ISO

Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA]

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

prolactin

affects expression

ISO

Cimetidine affects the expression of PRL protein

PMID:435711 PMID:9037573

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prokineticin 1

decreases expression

EXP

Cimetidine results in decreased expression of PROK1 protein

NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]

PMID:12065299 PMID:12107048 PMID:24300194

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

selectin P

decreases expression

ISO

Cimetidine results in decreased expression of SELP protein

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987

G

solute carrier family 22 member 1

increases uptake
multiple interactions

EXP
ISO

SLC22A1 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]

PMID:16006492 PMID:19357179

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions
increases transport
decreases response to substance
increases uptake

ISO
EXP

1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]
SLC22A2 protein results in increased transport of Cimetidine
SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine

PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 More...

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions
increases transport

ISO

Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
SLC22A3 protein results in increased transport of Cimetidine

PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 6

multiple interactions
increases uptake

ISO

1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]

PMID:15496291 PMID:16006492 PMID:16098483

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 7

increases uptake
multiple interactions

ISO

SLC22A7 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]

PMID:12065749 PMID:16006492

NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681

G

solute carrier family 22 member 8

multiple interactions
increases uptake
affects transport

ISO
EXP

Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]
SLC22A8 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]

PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More...

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 47 member 1

affects transport
multiple interactions
decreases activity

ISO

SLC47A1 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine results in decreased activity of SLC47A1 protein

PMID:16928787 PMID:21599003 PMID:27871888

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium]

PMID:21599003 PMID:27871888

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

solute carrier family 9 member A3

multiple interactions

EXP

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]

NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:30,953,216...30,996,002

G

tumor necrosis factor

multiple interactions

ISO

Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]

PMID:9088875 PMID:11856816

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Cinnarizine results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

dopamine receptor D2

affects binding
multiple interactions

ISO
EXP

Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]

PMID:7503767 PMID:11180191

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

parkin RBR E3 ubiquitin protein ligase

decreases response to substance

ISO

PRKN results in decreased susceptibility to Cinnarizine

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Clemastine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

histamine receptor H 1

multiple interactions

ISO

Clemastine binds to and results in decreased activity of HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Clemastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

EXP

[clemizole co-treated with Cisplatin] results in decreased expression of CAT protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

ISO

clemizole results in increased expression of CYP2B6 mRNA
[clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

ISO

clemizole results in increased expression of CYP3A4 mRNA
[clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

glucose-6-phosphatase catalytic subunit 1

increases expression

ISO

clemizole results in increased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

lipocalin 2

multiple interactions

EXP

[clemizole co-treated with Cisplatin] results in increased expression of LCN2 protein; clemizole inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

mediator complex subunit 1

multiple interactions

ISO

clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]

NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545

G

nuclear receptor coactivator 1

multiple interactions

ISO

clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

nuclear receptor coactivator 3

multiple interactions

ISO

clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein]

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

NPHS1 adhesion molecule, nephrin

multiple interactions

EXP

[Cisplatin co-treated with clemizole] results in decreased expression of NPHS1 protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of NPHS1 protein]

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO

[clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects localization
affects binding
multiple interactions

ISO

clemizole affects the localization of NR1I3 protein mutant form
clemizole binds to NR1I3 protein
[clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; clemizole binds to and results in increased activity of NR1I3 protein alternative form; clemizole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein]; clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein]

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

phosphoenolpyruvate carboxykinase 1

increases expression

ISO

clemizole results in increased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

Rac family small GTPase 1

multiple interactions

EXP

clemizole inhibits the reaction [Cisplatin results in increased expression of RAC1 protein]

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

stearoyl-CoA desaturase

decreases expression

ISO

clemizole results in decreased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

synaptopodin

multiple interactions

EXP

[Cisplatin co-treated with clemizole] results in decreased expression of SYNPO protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of SYNPO protein]

NCBI chr18:56,326,369...56,347,359
Ensembl chr18:56,319,571...56,353,306

G

thyroid hormone responsive

affects expression

ISO

clemizole affects the expression of THRSP mRNA

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

multiple interactions

ISO

clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

C-C motif chemokine ligand 2

decreases expression

ISO

clobenpropit results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

multiple interactions

ISO

[HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin dependent kinase 2

multiple interactions

ISO

[HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

ISO

[HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

histamine receptor H 1

multiple interactions

EXP

[Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H 2

multiple interactions

ISO
EXP

HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein]
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit

PMID:12235264 PMID:16488453

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041

G

histamine receptor H3

multiple interactions
affects binding

ISO
EXP

clobenpropit binds to and results in decreased activity of HRH3 protein; clobenpropit inhibits the reaction [[Methylhistamines binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium]
clobenpropit analog binds to HRH3 protein; clobenpropit binds to HRH3 protein
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit; [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine; clobenpropit binds to and results in decreased activity of HRH3 protein

PMID:12706455 PMID:16488453 PMID:22003888

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259

G

histamine receptor H4

multiple interactions
affects binding
increases response to substance

ISO

1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]; [clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein; clobenpropit binds to and results in increased activity of HRH4 protein
clobenpropit binds to HRH4 protein

PMID:17507084 PMID:22003888 PMID:22363581

NCBI chr18:4,440,977...4,457,132
Ensembl chr18:4,440,977...4,457,132

G

interferon gamma

affects expression

ISO

clobenpropit affects the expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 16

multiple interactions
increases expression

ISO

HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 5

affects expression

ISO

clobenpropit affects the expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

solute carrier family 22 member 3

multiple interactions

EXP
ISO

clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Clopenthixol results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of AARS1 protein

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Clozapine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

EXP
ISO

Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein

PMID:9111066 PMID:16810505

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

EXP

Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Clozapine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 3

decreases activity

ISO

Clozapine results in decreased activity of ABCC3 protein

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases activity

ISO

Clozapine results in decreased activity of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily E member 1

increases expression

ISO

Clozapine results in increased expression of ABCE1 protein

NCBI chr19:45,109,880...45,134,819
Ensembl chr19:45,109,906...45,134,819

G

ATP binding cassette subfamily G member 1

increases expression

ISO

Clozapine results in increased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

actin binding LIM protein family, member 2

increases expression

ISO

Clozapine results in increased expression of ABLIM2 mRNA

NCBI chr14:79,090,046...79,214,986
Ensembl chr14:79,090,923...79,214,972

G

acetyl-CoA acetyltransferase 2

increases expression

ISO

Clozapine results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

acyl-CoA thioesterase 2

increases expression

ISO

Clozapine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

acyl-CoA thioesterase 7

decreases expression

ISO

Clozapine results in decreased expression of ACOT7 protein

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:167,968,895...168,062,033

G

acyl-CoA oxidase 1

multiple interactions

EXP

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

actin, beta

decreases expression

ISO

Clozapine results in decreased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin, beta-like 2

increases expression

ISO

Clozapine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:44,591,391...44,594,138

G

actin related protein 3

decreases expression

ISO

Clozapine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

actin related protein 5

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein

NCBI chr 3:167,702,299...167,715,736
Ensembl chr 3:167,702,482...167,715,730

G

ADAM metallopeptidase domain 1a

decreases expression

EXP

Clozapine results in decreased expression of ADAM1A mRNA

NCBI chr12:40,674,460...40,680,988
Ensembl chr12:40,676,918...40,684,619

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein

NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:61,759,987...62,054,716

G

adenylate cyclase 5

affects response to substance
multiple interactions

ISO

ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression
multiple interactions

ISO
EXP

Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]

PMID:17933447 PMID:18162013 PMID:20564506

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adenosine A2a receptor

decreases expression

ISO

Clozapine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adrenoceptor alpha 1A

multiple interactions

EXP

Clozapine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

ISO

Clozapine results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,140,565...4,149,531
Ensembl chr20:4,140,565...4,150,445

G

angiotensinogen

multiple interactions

ISO

Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

ISO

Clozapine results in increased expression of AIMP1 protein

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994

G

adenylate kinase 1

decreases expression

ISO

Clozapine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

AKT serine/threonine kinase 1

increases expression
decreases expression
increases phosphorylation

ISO
EXP

Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein

PMID:15860345 PMID:19440698

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

increases expression

EXP

Clozapine results in increased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

albumin

multiple interactions
affects binding

EXP
ISO

Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A1

increases expression

ISO

Clozapine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldolase, fructose-bisphosphate A

increases expression

EXP

Clozapine results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

aldolase, fructose-bisphosphate B

increases expression
decreases expression

ISO

Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein

PMID:34122009 PMID:36482696

NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:68,684,542...68,716,740

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA

PMID:15860345 PMID:16465460

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133

G

alkaline phosphatase, placental

multiple interactions

ISO

Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451

G

Aly/REF export factor

decreases expression

ISO

Clozapine results in decreased expression of ALYREF protein

NCBI chr10:106,369,750...106,373,395
Ensembl chr10:106,369,750...106,373,395

G

annexin A1

decreases expression

ISO

Clozapine results in decreased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

decreases expression

ISO

Clozapine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

annexin A6

decreases expression

ISO

Clozapine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

ISO

Clozapine results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

adaptor related protein complex 2 subunit beta 1

increases expression

EXP

Clozapine results in increased expression of AP2B1 mRNA

NCBI chr10:68,596,925...68,702,547
Ensembl chr10:68,597,093...68,702,539

G

adaptor related protein complex 3 subunit beta 1

increases expression

ISO

Clozapine results in increased expression of AP3B1 protein

NCBI chr 2:27,331,241...27,535,683
Ensembl chr 2:27,334,900...27,537,702

G

apolipoprotein A5

affects response to substance

EXP

APOA5 gene polymorphism affects the susceptibility to Clozapine

NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:55,456,899...55,460,507

G

apolipoprotein D

increases expression

ISO

Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein

PMID:11158250 PMID:14647396 PMID:17266109

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

amyloid beta precursor protein

increases expression

ISO

Clozapine results in increased expression of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

activity-regulated cytoskeleton-associated protein

decreases expression

EXP

Clozapine results in decreased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

Cdc42 guanine nucleotide exchange factor 9

decreases expression

ISO

Clozapine results in decreased expression of ARHGEF9 mRNA

NCBI chr X:63,929,168...64,087,267
Ensembl chr X:63,929,176...64,087,104

G

ARF like GTPase 8A

decreases expression

ISO

Clozapine results in decreased expression of ARL8A protein

NCBI chr13:49,137,632...49,146,633
Ensembl chr13:49,137,632...49,146,633

G

acidic residue methyltransferase 1

increases expression

ISO

Clozapine results in increased expression of DCPH1 protein

NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:43,299,826...43,323,670

G

actin related protein 2/3 complex, subunit 4

affects expression

ISO

Clozapine affects the expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:148,077,240...148,088,428

G

N-acylsphingosine amidohydrolase 1

increases expression

ISO

Clozapine results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein

PMID:15342952 PMID:17175557 PMID:36482696

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartate-beta-hydroxylase

increases expression

ISO

Clozapine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215

G

argininosuccinate synthase 1

increases expression

ISO

Clozapine results in increased expression of ASS1 protein

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

ATPase family, AAA domain containing 3A

decreases expression

ISO

Clozapine results in decreased expression of ATAD3A protein

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:171,632,547...171,652,725

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

ISO

Clozapine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278

G

ATP synthase F1 subunit beta

decreases expression

EXP

Clozapine results in decreased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

ISO

Clozapine results in increased expression of ATP5PB protein

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387

G

ATPase H+ transporting V1 subunit A

decreases expression

ISO

Clozapine results in decreased expression of ATP6V1A protein

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit B1

decreases expression

ISO

Clozapine results in decreased expression of ATP6V1B1 protein

NCBI chr 4:117,781,444...117,800,103
Ensembl chr 4:117,781,444...117,800,103

G

ATPase H+ transporting V1 subunit B2

decreases expression

EXP
ISO

Clozapine results in decreased expression of ATP6V1B2 protein

PMID:19441803 PMID:34122009

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ataxin 10

increases expression

ISO

Clozapine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:118,319,490...118,445,636

G

axin 2

decreases expression

EXP

Clozapine results in decreased expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575

G

beta-secretase 2

increases expression

ISO

Clozapine results in increased expression of BACE2 protein

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:50,176,621...50,259,008

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

ISO
EXP

Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein

PMID:16160616 PMID:17069804

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein

NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511

G

BCAR1 scaffold protein, Cas family member

decreases expression

ISO

Clozapine results in decreased expression of BCAR1 protein

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

BCL2, apoptosis regulator

increases expression

EXP

Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 14

decreases expression

ISO

Clozapine results in decreased expression of BCL2L14 protein

NCBI chr 4:168,948,919...168,989,450
Ensembl chr 4:168,948,946...168,990,079

G

brain-derived neurotrophic factor

decreases expression
increases expression

EXP

Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein

PMID:11488957 PMID:12478621 PMID:17442489

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

Bet1 golgi vesicular membrane trafficking protein-like

decreases expression

EXP

Clozapine results in decreased expression of BET1L mRNA

NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:205,361,041...205,364,706

G

BCL2-interacting killer

multiple interactions
increases expression

ISO

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

bromodomain PHD finger transcription factor

decreases expression

ISO

Clozapine results in decreased expression of BPTF mRNA

NCBI chr10:92,480,007...92,582,485
Ensembl chr10:92,480,007...92,582,413

G

basic leucine zipper and W2 domains 1

increases expression

ISO

Clozapine results in increased expression of BZW1 protein

NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

ISO
EXP

Clozapine results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599

G

calcium binding and coiled coil domain 1

increases expression

ISO

Clozapine results in increased expression of CALCOCO1 protein

NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928

G

calmodulin 2

increases expression

EXP

Clozapine results in increased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657

G

calreticulin

decreases expression

ISO

Clozapine results in decreased expression of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

calumenin

decreases expression

ISO

Clozapine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein

PMID:15860345 PMID:17266109 PMID:19289156

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

EXP

Clozapine results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

EXP

Clozapine results in decreased expression of CAMK2D mRNA

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

calcium/calmodulin-dependent protein kinase IV

increases expression
decreases expression

EXP

Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein

PMID:15860345 PMID:19289156

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

EXP

Clozapine results in decreased expression of CAMKK1 protein

NCBI chr10:58,135,872...58,159,023
Ensembl chr10:58,135,915...58,159,010

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

EXP

Clozapine results in decreased expression of CAMKK2 protein

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964

G

calnexin

decreases expression

ISO

Clozapine results in decreased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

cysteinyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of CARS1 protein

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

CART prepropeptide

decreases expression

EXP

Clozapine results in decreased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712

G

caspase 1

increases activity

ISO

Clozapine results in increased activity of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

increases activity
multiple interactions

ISO
EXP

Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]

PMID:22700542 PMID:24709159

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity
multiple interactions

ISO

Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

catalase

multiple interactions

ISO

Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

Clozapine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 47

increases expression
multiple interactions

ISO

Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein

NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,630,106...91,648,626

G

cholecystokinin

multiple interactions
increases expression

EXP

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA

PMID:10974607 PMID:16567023

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686

G

cholecystokinin B receptor

increases expression

ISO

Clozapine results in increased expression of CCKBR mRNA

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745

G

C-C motif chemokine ligand 1

decreases expression

ISO

Clozapine results in decreased expression of CCL1 mRNA

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790

G

cyclin D1

decreases expression

EXP

Clozapine results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D3

increases expression

EXP

Clozapine results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin L1

increases expression

EXP

Clozapine results in increased expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

chaperonin containing TCP1 subunit 7

decreases expression

ISO

Clozapine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

Cd276 molecule

decreases expression

ISO

Clozapine results in decreased expression of CD276 protein

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

Cd63 molecule

increases expression

ISO

Clozapine results in increased expression of CD63 protein

NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

increases expression

ISO

Clozapine results in increased expression of CDIPT protein

NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:191,013,463...191,017,971

G

cyclin-dependent kinase 4

increases expression

EXP

Clozapine results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5

increases expression

EXP

Clozapine results in increased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

ISO

Clozapine results in increased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

ISO

Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

centromere protein V

increases expression

ISO

Clozapine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,713,778...47,727,679

G

cilia and flagella associated protein 210

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein

NCBI chr 3:74,928,368...74,962,508
Ensembl chr 3:74,927,880...74,962,497

G

coiled-coil-helix-coiled-coil-helix domain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein

NCBI chr12:32,464,847...32,470,871
Ensembl chr12:32,464,824...32,470,871

G

chromodomain helicase DNA binding protein 4

decreases expression

ISO

Clozapine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

chromogranin A

decreases expression
increases expression

EXP

Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA

NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237

G

cell adhesion molecule L1-like

decreases expression

ISO

Clozapine results in decreased expression of CHL1 mRNA

NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:137,847,895...138,062,077

G

chimerin 1

decreases expression

ISO

Clozapine results in decreased expression of CHN1 mRNA

NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:78,917,329...79,084,197

G

cysteine and histidine rich domain containing 1

increases expression

ISO

Clozapine results in increased expression of CHORDC1 protein

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

cholinergic receptor, muscarinic 1

affects binding
increases expression
multiple interactions

ISO
EXP

Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]

PMID:11997696 PMID:16983399 PMID:18806925

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cytoskeleton-associated protein 4

increases expression

ISO

Clozapine results in increased expression of CKAP4 protein

NCBI chr 7:21,118,527...21,126,624
Ensembl chr 7:21,118,085...21,126,624

G

chloride intracellular channel 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367

G

chloride intracellular channel 4

increases expression

ISO

Clozapine results in increased expression of CLIC4 protein

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

clock circadian regulator

affects response to substance

ISO

CLOCK gene SNP affects the susceptibility to Clozapine

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872

G

clathrin, light chain A

decreases expression

EXP

Clozapine results in decreased expression of CLTA mRNA

NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:63,041,184...63,059,215

G

clathrin, light chain B

decreases expression

EXP

Clozapine results in decreased expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA

PMID:17266109 PMID:34122009

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

coilin

increases expression

EXP

Clozapine results in increased expression of COIL mRNA

NCBI chr10:74,286,279...74,307,597
Ensembl chr10:74,286,840...74,307,595

G

collagen type V alpha 2 chain

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

catechol-O-methyltransferase

multiple interactions
affects response to substance
increases response to substance

EXP
ISO

[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine

PMID:15190105 PMID:17123785

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COP9 signalosome subunit 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein

NCBI chr10:45,117,664...45,151,868
Ensembl chr10:45,117,657...45,152,074

G

coronin 1B

decreases expression

ISO

Clozapine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876

G

complexin 2

decreases expression

ISO

Clozapine results in decreased expression of CPLX2 mRNA

NCBI chr17:10,224,673...10,297,974
Ensembl chr17:10,228,449...10,297,467

G

carboxypeptidase N subunit 1

increases expression

EXP

Clozapine results in increased expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

copine 1

decreases expression

ISO

Clozapine results in decreased expression of CPNE1 protein

NCBI chr 3:165,047,615...165,089,994

G

carnitine palmitoyltransferase 2

multiple interactions

EXP

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

ISO

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

corticotropin releasing hormone

decreases expression

ISO

Clozapine results in decreased expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

corticotropin releasing hormone binding protein

decreases expression

EXP

Clozapine results in decreased expression of CRHBP mRNA

NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446

G

C-reactive protein

increases expression

ISO

Clozapine results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

colony stimulating factor 3

multiple interactions

ISO

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

casein kinase 2 alpha 1

decreases expression

EXP

Clozapine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

cystatin C

increases expression

ISO

Clozapine results in increased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

cleavage stimulation factor subunit 1

decreases expression

ISO

Clozapine results in decreased expression of CSTF1 protein

NCBI chr 3:181,562,953...181,574,727
Ensembl chr 3:181,562,955...181,574,727

G

cleavage stimulation factor subunit 2

decreases expression

ISO

Clozapine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:101,546,819...101,572,764

G

C-terminal binding protein 1

increases expression

ISO

Clozapine results in increased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554

G

catenin beta 1

increases expression
multiple interactions

EXP

Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

chymotrypsin-like

increases expression

EXP

Clozapine results in increased expression of CTRL mRNA

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979

G

cathepsin K

increases expression

EXP

Clozapine results in increased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cortactin

increases expression

ISO

Clozapine results in increased expression of CTTN protein

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

cullin 2

increases expression

ISO

Clozapine results in increased expression of CUL2 protein

NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132

G

cullin 3

increases expression

ISO

Clozapine results in increased expression of CUL3 protein

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

C-X-C motif chemokine ligand 1

decreases expression
decreases secretion
multiple interactions
increases secretion

ISO
EXP

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]

PMID:17346280 PMID:34935985 PMID:36482696

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases secretion

ISO

Clozapine results in decreased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 3

decreases expression
decreases secretion

ISO

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:36482696

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

similar to human chromosome X open reading frame 49

increases expression

ISO

Clozapine results in increased expression of CXORF49 protein

NCBI chr X:70,951,401...70,955,380
Ensembl chr X:70,951,410...70,955,378

G

cytochrome b5 type B

increases expression

EXP

Clozapine results in increased expression of CYB5B mRNA

NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980

G

cytochrome b5 reductase 1

increases expression

ISO

Clozapine results in increased expression of CYB5R1 protein

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases metabolic processing

EXP
ISO

Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine

PMID:18493746 PMID:18809730 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing

ISO
EXP

CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine

PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
decreases activity

ISO

CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein

PMID:18809730 PMID:33814510

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases metabolic processing

ISO

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

ISO

CYP2C8 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
increases metabolic processing
multiple interactions

ISO

CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine

PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases metabolic processing

ISO

CYP2J2 protein results in increased metabolism of Clozapine

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
decreases activity
affects metabolic processing
multiple interactions

ISO

CYP3A4 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

ISO

CYP3A5 protein results in increased metabolism of Clozapine

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

DAB adaptor protein 1

increases expression

EXP

Clozapine results in increased expression of DAB1 mRNA

NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584

G

DAB adaptor protein 2

increases expression

ISO

Clozapine results in increased expression of DAB2 protein

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888

G

diacylglycerol lipase, beta

increases expression

ISO

Clozapine results in increased expression of DAGLB protein

NCBI chr12:16,173,345...16,215,777
Ensembl chr12:16,173,345...16,215,758

G

DDB1 and CUL4 associated factor 6

decreases expression

ISO

Clozapine results in decreased expression of DCAF6 mRNA

NCBI chr13:80,159,282...80,260,510
Ensembl chr13:80,159,321...80,260,510

G

doublecortin-like kinase 1

increases expression

ISO
EXP

Clozapine results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090

G

dopa decarboxylase

multiple interactions
increases expression

ISO

Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DEAD-box helicase 46

increases expression

ISO

Clozapine results in increased expression of DDX46 protein

NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,947,237...8,990,247

G

DENN domain containing 10

increases expression

EXP

Clozapine results in increased expression of DENND10 mRNA

NCBI chr 1:269,937,023...269,960,506
Ensembl chr 1:269,936,895...269,962,853

G

DEPP autophagy regulator 1

increases expression

ISO

Clozapine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

DiGeorge syndrome critical region gene 6

decreases expression

ISO

Clozapine results in decreased expression of DGCR6 protein

NCBI chr11:96,432,024...96,442,766
Ensembl chr11:96,432,024...96,437,255

G

diacylglycerol kinase, alpha

decreases expression

EXP

Clozapine results in decreased expression of DGKA mRNA

NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569

G

24-dehydrocholesterol reductase

increases expression

ISO

Clozapine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

7-dehydrocholesterol reductase

increases expression

ISO

Clozapine results in increased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

DExH-box helicase 30

increases expression

ISO

Clozapine results in increased expression of DHX30 protein

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592

G

DEAH-box helicase 38

decreases expression

ISO

Clozapine results in decreased expression of DHX38 protein

NCBI chr19:54,422,418...54,439,434
Ensembl chr19:54,422,418...54,439,423

G

DISC1 scaffold protein

decreases response to substance
affects response to substance

ISO

DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine

NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970

G

dihydrolipoamide S-acetyltransferase

decreases expression
increases expression

EXP
ISO

Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein

PMID:15860345 PMID:34122009

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Clozapine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

dihydrolipoamide S-succinyltransferase

decreases expression

ISO

Clozapine results in decreased expression of DLST protein

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357

G

dynein, axonemal, heavy chain 11

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein

NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:144,973,797...145,298,692

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

ISO

Clozapine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

double PHD fingers 1

affects expression

ISO

Clozapine affects the expression of DPF1 mRNA

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:93,726,970...93,743,425

G

dipeptidylpeptidase 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310

G

dihydropyrimidinase-like 3

decreases expression

ISO

Clozapine results in decreased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dihydropyrimidinase-like 4

decreases expression

ISO

Clozapine results in decreased expression of DPYSL4 protein

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

down-regulator of transcription 1

decreases expression

ISO

Clozapine results in decreased expression of DR1 protein

NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,603,204...1,614,556

G

dopamine receptor D1

affects binding
decreases expression
affects response to substance

ISO
EXP

Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance

ISO
EXP

[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

affects response to substance
multiple interactions
decreases response to substance

ISO

DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine

PMID:15579174 PMID:20029384

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

dopamine receptor D4

affects binding
multiple interactions
affects response to substance

ISO
EXP

Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine

CTD
RGD

PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458

G

dystrophin related protein 2

increases expression

EXP

Clozapine results in increased expression of DRP2 mRNA alternative form

NCBI chr X:101,900,743...101,951,403
Ensembl chr X:101,901,011...101,951,403

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

ISO

DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine

NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,891,337...19,984,418

G

dual specificity phosphatase 1

decreases expression

EXP

Clozapine results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 6

decreases expression

EXP

Clozapine results in decreased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

dishevelled segment polarity protein 3

increases expression
multiple interactions

EXP

Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]

NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

ISO

Clozapine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

ISO

Clozapine results in decreased expression of DYNC1LI2 protein

NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107

G

enhancer of mRNA decapping 4

increases expression

ISO

Clozapine results in increased expression of EDC4 protein

NCBI chr19:50,683,924...50,695,916
Ensembl chr19:50,683,897...50,697,620

G

eukaryotic translation elongation factor 1 alpha 2

increases expression

ISO

Clozapine results in increased expression of EEF1A2 protein

NCBI chr 3:188,643,455...188,652,633
Ensembl chr 3:188,643,458...188,677,712

G

eukaryotic translation elongation factor 1 delta

decreases expression

ISO

Clozapine results in decreased expression of EEF1D protein

NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531

G

early growth response 1

decreases expression

EXP

Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein

PMID:17028028 PMID:18208916

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

affects expression
decreases expression

ISO
EXP

Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein

PMID:17028028 PMID:19401217

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 3

affects response to substance

ISO

EGR3 protein affects the susceptibility to Clozapine

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

ISO

Clozapine results in increased expression of EIF2S3 protein

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3, subunit J

increases expression

ISO

Clozapine results in increased expression of EIF3J protein

NCBI chr 3:129,438,715...129,460,953
Ensembl chr 3:129,438,722...129,462,246

G

eukaryotic translation initiation factor 3, subunit M

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein

NCBI chr 3:111,879,589...111,897,193
Ensembl chr 3:111,870,925...111,897,193

G

eukaryotic translation initiation factor 4A3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein

NCBI chr10:105,047,567...105,057,561
Ensembl chr10:105,047,568...105,058,207

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 5B

increases expression

ISO

Clozapine results in increased expression of EIF5B protein

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

eukaryotic translation initiation factor 6

decreases expression

ISO

Clozapine results in decreased expression of EIF6 protein

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

ETS transcription factor ELK1

decreases phosphorylation

ISO

Clozapine results in decreased phosphorylation of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

enolase 1

increases expression

EXP

Clozapine results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

enolase 3

increases expression

ISO

Clozapine results in increased expression of ENO3 protein

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540

G

Eph receptor A7

increases expression

ISO

Clozapine results in increased expression of EPHA7 mRNA

NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:47,771,865...47,925,058

G

Eph receptor B3

increases expression

ISO

Clozapine results in increased expression of EPHB3 protein

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

endoplasmic reticulum aminopeptidase 1

decreases expression

ISO

Clozapine results in decreased expression of ERAP1 protein

NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:5,666,436...5,740,056

G

erb-b2 receptor tyrosine kinase 2

affects phosphorylation

EXP

Clozapine affects the phosphorylation of ERBB2 protein

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

EXP

Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772

G

ERH, mRNA splicing and mitosis factor

increases expression

ISO

Clozapine results in increased expression of ERH protein

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

endoplasmic reticulum protein 44

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein

NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:67,312,098...67,406,444

G

EWS RNA-binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein

NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095

G

exosome component 4

increases expression

ISO

Clozapine results in increased expression of EXOSC4 protein

NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820

G

ezrin

decreases expression

ISO

Clozapine results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

fatty acid binding protein 1

increases expression

ISO

Clozapine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

FANCD2 and FANCI associated nuclease 1

increases expression

ISO

Clozapine results in increased expression of FAN1 protein

NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:127,330,016...127,356,400

G

phenylalanyl-tRNA synthetase subunit alpha

increases expression

ISO

Clozapine results in increased expression of FARSA protein

NCBI chr19:40,196,255...40,205,830
Ensembl chr19:40,173,716...40,205,823

G

phenylalanyl-tRNA synthetase subunit beta

increases expression

ISO

Clozapine results in increased expression of FARSB protein

NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:87,336,326...87,395,505

G

Fas cell surface death receptor

multiple interactions

ISO

[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

ISO

[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

increases expression

ISO

Clozapine results in increased expression of FASN mRNA

PMID:16027736 PMID:17052361

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

farnesyl diphosphate synthase

increases expression

ISO

Clozapine results in increased expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

flap structure-specific endonuclease 1

increases expression

ISO

Clozapine results in increased expression of FEN1 protein

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

fibroblast growth factor 2

increases expression

EXP

Clozapine results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibrinogen-like 1

increases expression

ISO

Clozapine results in increased expression of FGL1 protein

NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429

G

formin homology 2 domain containing 1

decreases expression

ISO

Clozapine results in decreased expression of FHOD1 protein

NCBI chr19:50,116,415...50,135,868
Ensembl chr19:50,116,415...50,135,330

G

FKBP prolyl isomerase 8

decreases expression

ISO

Clozapine results in decreased expression of FKBP8 protein

NCBI chr16:18,929,581...18,936,621
Ensembl chr16:18,929,582...18,936,543

G

flotillin 2

increases expression

ISO

Clozapine results in increased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

ISO

FMO1 protein results in increased metabolism of Clozapine

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

flavin containing dimethylaniline monoxygenase 3

increases metabolic processing

ISO

FMO3 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

fibronectin type III domain containing 4

increases expression

ISO

Clozapine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

EXP
ISO

Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in increased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein

PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
decreases expression

ISO
EXP

Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA

PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

FOS like 1, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of FOSL2 mRNA

PMID:12093589 PMID:12243769

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box P2

increases expression

ISO

Clozapine results in increased expression of FOXP2 mRNA

NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696

G

follistatin-like 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein

NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126

G

far upstream element binding protein 1

increases expression

ISO

Clozapine results in increased expression of FUBP1 protein

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

Clozapine results in decreased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GABA type A receptor associated protein like 2

increases expression

ISO

Clozapine results in increased expression of GABARAPL2 protein

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660

G

gamma-aminobutyric acid type B receptor subunit 1

decreases expression

ISO

Clozapine results in decreased expression of GABBR1 mRNA

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

ISO

Clozapine results in increased expression of GABRA1 mRNA

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases expression

EXP

Clozapine results in increased expression of GABRB3 mRNA

NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725

G

glutamate decarboxylase 1

increases expression
decreases methylation
multiple interactions

ISO
EXP

Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]

PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

glutamate decarboxylase 2

increases expression

ISO
EXP

Clozapine results in increased expression of GAD2 mRNA

PMID:17266109 PMID:18923069

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

EXP
ISO

Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein

PMID:15860345 PMID:34122009

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

increases expression

ISO

Clozapine results in increased expression of GART protein

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

glycine amidinotransferase

increases expression

ISO

Clozapine results in increased expression of GATM protein

NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355

G

GRIP and coiled-coil domain containing 2

decreases expression

ISO

Clozapine results in decreased expression of GCC2 protein

NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,790,516...26,836,726

G

growth differentiation factor 15

increases expression

ISO

Clozapine results in increased expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

ISO

Clozapine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606

G

glial fibrillary acidic protein

decreases expression
increases expression

EXP

Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA

PMID:18585900 PMID:19441803

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

growth hormone inducible transmembrane protein

increases expression

ISO

Clozapine results in increased expression of GHITM protein

NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123

G

GTPase, IMAP family member 5

decreases expression

EXP

Clozapine results in decreased expression of GIMAP5 mRNA

NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:79,024,304...79,039,030

G

gastric inhibitory polypeptide

increases expression

EXP

Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein

NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216

G

gap junction protein, alpha 1

increases expression

EXP

Clozapine results in increased expression of GJA1 protein

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glucagon-like peptide 1 receptor

multiple interactions
decreases expression

EXP

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]

NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654

G

glutaredoxin 3

increases expression

ISO

Clozapine results in increased expression of GLRX3 protein

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glutamate-ammonia ligase

decreases expression

ISO

Clozapine results in decreased expression of GLUL protein

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

G protein subunit alpha 12

decreases expression
increases expression

EXP
ISO

Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein

PMID:15860345 PMID:34122009

NCBI chr12:18,919,629...19,000,185
Ensembl chr12:18,919,629...19,000,185

G

G protein subunit alpha i1

decreases expression

EXP

Clozapine results in decreased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

decreases expression

EXP

Clozapine results in decreased expression of GNAI2 mRNA

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

G protein subunit alpha i3

decreases expression

EXP

Clozapine results in decreased expression of GNAI3 mRNA

NCBI chr 2:198,430,920...198,468,874

G

GNAS complex locus

decreases expression
multiple interactions
increases expression

EXP
ISO

Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein

PMID:15860345 PMID:34122009

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536

G

G protein subunit beta 3

decreases response to substance
increases expression
affects response to substance
increases response to substance

ISO
EXP

GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine

PMID:16139171 PMID:16141801 PMID:18855531

NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:159,325,742...159,331,445

G

golgin A3

increases expression

ISO

Clozapine results in increased expression of GOLGA3 protein

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

golgin B1

increases expression

ISO

Clozapine results in increased expression of GOLGB1 protein

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006

G

glutamic-oxaloacetic transaminase 2

increases expression
multiple interactions

EXP
ISO

Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein

PMID:15860345 PMID:34122009

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

glycerol-3-phosphate dehydrogenase 2

decreases expression

ISO

Clozapine results in decreased expression of GPD2 protein

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

glucose-6-phosphate isomerase

increases expression

ISO

Clozapine results in increased expression of GPI protein

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression

ISO

Clozapine results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

EXP

Clozapine results in increased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202

G

glutamate ionotropic receptor kainate type subunit 5

affects expression
decreases expression

ISO
EXP

Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA

PMID:14647396 PMID:18923069

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA

PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

EXP

Clozapine results in decreased expression of GRIN2A mRNA

PMID:12608697 PMID:18923069

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

EXP

Clozapine results in decreased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

EXP

Clozapine results in decreased expression of GRIN2C mRNA

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409

G

G protein-coupled receptor kinase 6

decreases expression

EXP

Clozapine results in decreased expression of GRK6 mRNA

NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954

G

glycogen synthase kinase 3 alpha

increases expression
multiple interactions

EXP

Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593

G

glycogen synthase kinase 3 beta

increases phosphorylation
increases expression
multiple interactions

ISO
EXP

Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]

PMID:16144542 PMID:19359144 PMID:19440698

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase alpha 1

decreases activity
increases glutathionylation

ISO

GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase mu 1

decreases activity
increases expression
increases glutathionylation

ISO
EXP

GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine

PMID:15860345 PMID:20849150

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases expression

EXP

Clozapine results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

decreases activity
affects metabolic processing
increases glutathionylation
affects binding

ISO

Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein

PMID:20849150 PMID:21639118 PMID:24185126

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

H1.2 linker histone, cluster member

increases expression

ISO

Clozapine results in increased expression of H1-2 protein

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

H2A clustered histone 18

increases expression

ISO

Clozapine results in increased expression of H2AC18 mRNA

NCBI chr 2:186,497,271...186,497,865

G

H2A clustered histone 20

increases expression

ISO

Clozapine results in increased expression of H2AC20 protein

NCBI chr 2:186,468,748...186,469,226

G

H2A.J histone

increases expression

ISO

Clozapine results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

ISO

Clozapine results in decreased expression of HAAO protein

NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:16,598,087...16,617,356

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

ISO

Clozapine results in increased expression of HACD3 protein

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

Clozapine results in increased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

histidyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of HARS1 protein

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712

G

histone acetyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

hematopoietic cell specific Lyn substrate 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein

NCBI chr11:77,322,873...77,346,333
Ensembl chr11:77,322,873...77,346,387

G

HDGF like 2

increases expression

ISO

Clozapine results in increased expression of HDGFRP2 protein

NCBI chr 9:996,687...1,016,352
Ensembl chr 9:996,758...1,016,735

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

ISO

Clozapine results in increased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

high mobility group box 2

increases expression

ISO

Clozapine results in increased expression of HMGB2 protein

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression
increases activity

ISO

[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

Clozapine results in increased expression of HMGCS1 mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heme oxygenase 1

increases expression

ISO

Clozapine results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

ISO

Clozapine results in decreased expression of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

heterogeneous nuclear ribonucleoprotein H2

decreases expression

ISO

Clozapine results in decreased expression of HNRNPH2 protein

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

homer scaffold protein 1

increases expression
multiple interactions

EXP

Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]

PMID:12464447 PMID:15860345

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

hippocalcin-like 1

decreases expression

EXP

Clozapine results in decreased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

hippocalcin-like 4

affects expression

EXP

Clozapine affects the expression of HPCAL4 mRNA

NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530

G

hepsin

increases expression

ISO

Clozapine results in increased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199

G

histamine receptor H 1

affects binding

ISO

Clozapine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H3

multiple interactions

EXP

Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]

RGD

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

ISO

Clozapine results in decreased expression of HSD17B10 protein

NCBI chr X:24,568,551...24,571,012
Ensembl chr X:24,568,551...24,574,681

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

ISO

Clozapine results in increased expression of HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

heat shock protein family A (Hsp70) member 9

decreases expression

ISO

Clozapine results in decreased expression of HSPA9 protein

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

5-hydroxytryptamine receptor 1A

multiple interactions
affects binding

ISO
EXP

Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein

PMID:9723970 PMID:15482641

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 1D

decreases expression

EXP

Clozapine results in decreased expression of HTR1D mRNA

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

5-hydroxytryptamine receptor 2A

increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression

ISO
EXP

HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA

PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More...

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 2C

affects binding
decreases expression
affects response to substance

ISO
EXP

Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine

PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More...

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

5-hydroxytryptamine receptor 3A

multiple interactions
affects response to substance

ISO

Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine

PMID:19696922 PMID:20168265

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

G

5-hydroxytryptamine receptor 6

multiple interactions
affects binding

ISO

Clozapine binds to and results in decreased activity of HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
Clozapine binds to HTR6 protein

PMID:11406289 PMID:16983399 PMID:34122009

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

ISO

Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230

G

inhibitor of DNA binding 2

increases expression

EXP

Clozapine results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Clozapine results in decreased expression of IDI1 protein

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

interferon gamma

affects expression
decreases expression

ISO

Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 1

increases expression

ISO

Clozapine results in increased expression of IFNGR1 protein

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

insulin-like growth factor 1

decreases expression

ISO

Clozapine results in decreased expression of IGF1 protein

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 1

increases expression

ISO

Clozapine results in increased expression of IGFBP1 protein

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

interleukin 10

decreases expression

EXP

Clozapine results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

increases secretion
multiple interactions

EXP

Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2 receptor subunit alpha

increases secretion

ISO

Clozapine results in increased secretion of IL2RA protein

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 5

affects expression

ISO

Clozapine affects the expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

ILK associated serine/threonine phosphatase

decreases expression

EXP

Clozapine results in decreased expression of ILKAP mRNA

NCBI chr 9:99,413,981...99,436,262
Ensembl chr 9:99,413,978...99,436,418

G

inhibin subunit alpha

decreases expression

EXP

Clozapine results in decreased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

inhibin subunit beta E

increases expression

ISO

Clozapine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

insulin 2

affects secretion
increases expression

ISO

Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein

PMID:11769361 PMID:16601995

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

integrin subunit alpha 6

increases expression

ISO

Clozapine results in increased expression of ITGA6 protein

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

Janus kinase 1

increases expression

ISO

Clozapine results in increased expression of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

multiple interactions

EXP

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

EXP

Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA

PMID:12093589 PMID:15860345 PMID:18208916

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of JUNB mRNA

PMID:12093589 PMID:19695244

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Clozapine results in decreased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

potassium voltage-gated channel subfamily A member 1

increases expression

ISO

Clozapine results in increased expression of KCNA1 mRNA

NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

ISO

Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel interacting protein 3

decreases expression
increases expression

ISO

Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216

G

potassium two pore domain channel subfamily K member 2

decreases expression

ISO

Clozapine results in decreased expression of KCNK2 mRNA

NCBI chr13:103,297,387...103,494,686
Ensembl chr13:103,297,393...103,494,686

G

potassium channel tetramerization domain containing 12

decreases expression

ISO

Clozapine results in decreased expression of KCTD12 protein

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

kinase insert domain receptor

increases expression

ISO

Clozapine results in increased expression of KDR protein

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

ISO

Clozapine results in decreased expression of KHDRBS1 protein

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448

G

kinesin family member 13B

increases expression

ISO

Clozapine results in increased expression of KIF13B protein

NCBI chr15:43,084,059...43,241,719
Ensembl chr15:43,080,910...43,241,719

G

kinesin family member 5C

decreases expression

ISO

Clozapine results in decreased expression of KIF5C protein

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813

G

kizuna centrosomal protein

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein

NCBI chr 3:154,730,873...154,838,410
Ensembl chr 3:154,730,634...154,838,410

G

kelch domain containing 2

decreases expression

ISO

Clozapine results in decreased expression of KLHDC2 protein

NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762

G

lysine methyltransferase 2A

increases expression
decreases expression
multiple interactions

ISO

Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]

PMID:14647396 PMID:17942719

NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317

G

karyopherin subunit alpha 4

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein

NCBI chr 2:155,635,679...155,691,056
Ensembl chr 2:155,634,247...155,691,053

G

kringle containing transmembrane protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein

NCBI chr14:84,295,931...84,361,534
Ensembl chr14:84,297,700...84,361,614

G

lactamase, beta 2

increases expression

ISO

Clozapine results in increased expression of LACTB2 protein

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255

G

lysosomal-associated membrane protein 1

increases expression

ISO

Clozapine results in increased expression of LAMP1 protein

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

increases expression

ISO

Clozapine results in increased expression of LAMTOR3 mRNA

NCBI chr 2:229,084,795...229,097,028
Ensembl chr 2:229,084,858...229,099,383

G

La ribonucleoprotein 7, transcriptional regulator

increases expression

ISO

Clozapine results in increased expression of LARP7 protein

NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308

G

lipocalin 1

decreases expression

ISO

Clozapine results in decreased expression of LCN1 protein

NCBI chr 3:29,930,943...29,935,418

G

lactate dehydrogenase B

increases expression

EXP

Clozapine results in increased expression of LDHB mRNA

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

low density lipoprotein receptor

increases expression
multiple interactions

ISO

Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]

PMID:17052361 PMID:20564506

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

liver enriched antimicrobial peptide 2

increases expression

ISO

Clozapine results in increased expression of LEAP2 mRNA

NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073

G

LEM domain nuclear envelope protein 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein

NCBI chr20:5,284,275...5,298,281
Ensembl chr20:5,284,275...5,298,328

G

leptin

affects response to substance
increases expression

ISO
EXP

LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein

PMID:16402076 PMID:17502770

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

galectin 8

increases expression

ISO

Clozapine results in increased expression of LGALS8 protein

NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482

G

lipase A, lysosomal acid type

increases expression

ISO

Clozapine results in increased expression of LIPA protein

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740

G

leiomodin 2

increases expression

ISO

Clozapine results in increased expression of LMOD2 protein

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666

G

lipoprotein lipase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA

PMID:17266109 PMID:19682446

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LDL receptor related protein 10

increases expression

ISO

Clozapine results in increased expression of LRP10 protein

NCBI chr15:31,891,358...31,897,530
Ensembl chr15:31,891,362...31,897,528

G

leucine-rich pentatricopeptide repeat containing

increases expression

ISO

Clozapine results in increased expression of LRPPRC protein

NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116

G

leucine-rich repeat kinase 2

increases expression

ISO

Clozapine results in increased expression of LRRK2 protein

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

lanosterol synthase

increases expression
multiple interactions

ISO

Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein

PMID:15342952 PMID:17175557 PMID:34122009

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

leukotriene A4 hydrolase

decreases expression

ISO

Clozapine results in decreased expression of LTA4H protein

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

magnesium transporter 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein

NCBI chr X:75,104,040...75,145,247
Ensembl chr X:75,106,172...75,145,365

G

mal, T-cell differentiation protein

decreases expression

ISO

Clozapine results in decreased expression of MAL mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

monoamine oxidase B

increases expression

ISO

Clozapine results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 1A

increases expression
decreases expression

EXP
ISO

Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein

PMID:15860345 PMID:34122009

NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159

G

microtubule-associated protein 1B

decreases expression

ISO

Clozapine results in decreased expression of MAP1B protein

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

microtubule-associated protein 1 light chain 3 beta

increases lipidation
multiple interactions

ISO

Clozapine results in increased lipidation of MAP1LC3B protein
[Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 1S

increases expression

ISO

Clozapine results in increased expression of MAP1S protein

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141

G

mitogen activated protein kinase kinase 1

decreases expression

EXP

Clozapine results in decreased expression of MAP2K1 mRNA

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

increases expression
decreases expression

ISO
EXP

Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA

PMID:14647396 PMID:15860345

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 5

decreases expression

EXP

Clozapine results in decreased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373

G

mitogen-activated protein kinase kinase kinase 1

increases expression

EXP

Clozapine results in increased expression of MAP3K1 mRNA

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase kinase kinase 12

increases expression

EXP

Clozapine results in increased expression of MAP3K12 mRNA

NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137

G

mitogen activated protein kinase 1

multiple interactions
decreases expression
decreases phosphorylation

ISO
EXP

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein

PMID:12871586 PMID:15860345

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

affects expression

EXP

Clozapine affects the expression of MAPK14 mRNA

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

ISO

Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 6

affects expression

EXP

Clozapine affects the expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

mitogen-activated protein kinase 8 interacting protein 1

increases expression

ISO

Clozapine results in increased expression of MAPK8IP1 mRNA

NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368

G

mitogen-activated protein kinase 9

affects expression

EXP

Clozapine affects the expression of MAPK9 mRNA

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein, RP/EB family, member 1

decreases expression
multiple interactions

ISO

Clozapine results in decreased expression of MAPRE1 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210

G

MAS1 proto-oncogene, G protein-coupled receptor

decreases expression

EXP

Clozapine results in decreased expression of MAS1 mRNA

NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561

G

methionine adenosyltransferase 2A

decreases expression

ISO

Clozapine results in decreased expression of MAT2A protein

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

methionine adenosyltransferase 2 non-catalytic beta subunit

decreases expression

ISO

Clozapine results in decreased expression of MAT2B protein

NCBI chr10:25,609,202...25,626,694
Ensembl chr10:25,609,204...25,625,176

G

myelin basic protein

increases expression

ISO

Clozapine results in increased expression of MBP mRNA

PMID:17266109 PMID:17346280

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

melanocortin 1 receptor

increases expression

ISO

Clozapine results in increased expression of MC1R mRNA

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877

G

mediator of DNA damage checkpoint 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein

NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,900,308...2,914,960

G

malate dehydrogenase 1

decreases expression

ISO

Clozapine results in decreased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

mitofusin 2

decreases expression
multiple interactions

EXP

Clozapine results in decreased expression of MFN2 protein
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

mixed lineage kinase domain like pseudokinase

increases expression

ISO

Clozapine results in increased expression of MLKL protein

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

matrix metallopeptidase 10

decreases expression

ISO

Clozapine results in decreased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

matrix metallopeptidase 14

increases expression

ISO

Clozapine results in increased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 7

decreases expression

ISO

Clozapine results in decreased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

myelin-associated oligodendrocyte basic protein

increases expression

ISO

Clozapine results in increased expression of MOBP mRNA

PMID:15542763 PMID:17266109

NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:128,747,232...128,777,936

G

myeloperoxidase

affects response to substance
increases activity
multiple interactions
increases oxidation

ISO

MPO protein affects the susceptibility to Clozapine
Clozapine results in increased activity of MPO protein
Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]
MPO protein results in increased oxidation of Clozapine

PMID:24588327 PMID:35575633

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MAGUK p55 scaffold protein 3

decreases expression

ISO

Clozapine results in decreased expression of MPP3 mRNA

NCBI chr10:87,445,905...87,475,461
Ensembl chr10:87,445,905...87,474,811

G

major histocompatibility complex, class I-related

affects expression

ISO

Clozapine affects the expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

metastasis associated 1 family, member 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein

NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062

G

metadherin

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

methylenetetrahydrofolate reductase

affects response to substance

ISO

MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

myeloid-associated differentiation marker

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein

NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:74,775,698...74,789,710

G

MYB binding protein 1a

increases expression

ISO

Clozapine results in increased expression of MYBBP1A protein

NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,555,452...57,566,041

G

myosin heavy chain 10

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036

G

myosin heavy chain 3

increases expression

ISO

Clozapine results in increased expression of MYH3 protein

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

myosin, light chain 1

increases expression

ISO

Clozapine results in increased expression of MYL1 protein

Ensembl chr 9:75,887,227...75,907,971

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

decreases expression

ISO

Clozapine results in decreased expression of NAA10 protein

NCBI chr X:156,807,378...156,812,632
Ensembl chr X:156,807,378...156,812,574

G

nucleosome assembly protein 1-like 4

increases expression

ISO

Clozapine results in increased expression of NAP1L4 protein

NCBI chr 1:208,139,105...208,175,597
Ensembl chr 1:208,139,113...208,174,569

G

N-acetyltransferase 10

decreases expression

ISO

Clozapine results in decreased expression of NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836

G

neurocan

decreases expression

ISO

Clozapine results in decreased expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371

G

non-SMC condensin I complex, subunit G

increases expression

ISO

Clozapine results in increased expression of NCAPG protein

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

non-SMC condensin I complex, subunit H

decreases expression

ISO

Clozapine results in decreased expression of NCAPH protein

PMID:34122009 PMID:36482696

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

nuclear cap binding protein subunit 1

decreases expression

ISO

Clozapine results in decreased expression of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

nucleolin

increases expression

ISO

Clozapine results in increased expression of NCL mRNA

NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083

G

nuclear receptor coactivator 4

increases expression

ISO

Clozapine results in increased expression of NCOA4 protein

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

EXP

Clozapine results in increased expression of NDUFV2 mRNA

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

nectin cell adhesion molecule 2

decreases expression

ISO

Clozapine results in decreased expression of NECTIN2 protein

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

ISO

Clozapine results in decreased expression of NEDD4 mRNA

NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633

G

nestin

decreases expression

ISO

Clozapine results in decreased expression of NES protein

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

NFE2 like bZIP transcription factor 2

affects response to substance

ISO

NFE2L2 protein affects the susceptibility to Clozapine

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

decreases expression

EXP

Clozapine results in decreased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nerve growth factor receptor

decreases expression

ISO
EXP

Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA

PMID:12111809 PMID:14598305 PMID:16513140

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

nucleolar protein interacting with the FHA domain of MKI67

decreases expression

ISO

Clozapine results in decreased expression of NIFK protein

NCBI chr13:31,946,119...31,955,950
Ensembl chr13:31,946,108...31,959,561

G

nicotinamide N-methyltransferase

increases expression

ISO

Clozapine results in increased expression of NNMT protein

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

nicotinamide nucleotide transhydrogenase

decreases expression

ISO

Clozapine results in decreased expression of NNT protein

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

ISO

Clozapine results in increased expression of NOC2L protein

NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:172,101,223...172,114,162

G

Nodal modulator 1

increases expression

ISO

Clozapine results in increased expression of NOMO3 protein

NCBI chr 1:105,641,867...105,692,708
Ensembl chr 1:105,641,879...105,692,707

G

NOP53 ribosome biogenesis factor

affects expression

ISO

Clozapine affects the expression of NOP53 mRNA

NCBI chr 1:85,757,271...85,765,089
Ensembl chr 1:85,756,586...85,765,089

G

notch receptor 2

increases expression

ISO

Clozapine results in increased expression of NOTCH2 protein

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823

G

NPL4 homolog, ubiquitin recognition factor

decreases expression

ISO

Clozapine results in decreased expression of NPLOC4 protein

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

neuroplastin

increases expression

ISO

Clozapine results in increased expression of NPTN mRNA

NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:67,892,702...67,959,236

G

neuronal pentraxin 2

decreases expression

EXP

Clozapine results in decreased expression of NPTX2 mRNA

NCBI chr12:15,151,136...15,162,045
Ensembl chr12:15,151,136...15,162,045

G

neuropeptide Y

decreases expression

EXP

Clozapine results in decreased expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects response to substance
increases reduction
multiple interactions

ISO

NQO2 gene SNP affects the susceptibility to Clozapine
NQO2 protein results in increased reduction of Clozapine metabolite
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]

PMID:14617031 PMID:29281794

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ISO

Clozapine results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

ISO

Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

increases expression
decreases expression

EXP

Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA

PMID:10987852 PMID:11564422 PMID:19695244

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

increases expression

ISO

Clozapine results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

neuregulin 1

increases expression
affects expression
affects response to substance

ISO
EXP

Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine

PMID:15706234 PMID:18184445 PMID:19502011

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

ISO

Clozapine results in decreased expression of NSF protein

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

netrin G2

increases expression

EXP

Clozapine results in increased expression of NTNG2 mRNA

NCBI chr 3:32,889,856...32,949,032
Ensembl chr 3:32,890,575...32,943,821

G

neurotensin

increases expression

EXP

Clozapine results in increased expression of NTS mRNA

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nuclear mitotic apparatus protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein

NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848

G

NUMB-like, endocytic adaptor protein

decreases expression

ISO

Clozapine results in decreased expression of NUMBL mRNA

NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424

G

nucleoporin 160

increases expression

ISO

Clozapine results in increased expression of NUP160 protein

NCBI chr 3:97,120,723...97,183,227
Ensembl chr 3:97,121,628...97,180,720

G

nucleoporin 50

increases expression

ISO

Clozapine results in increased expression of NUP50 protein

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959

G

nucleoporin 54

decreases expression

ISO

Clozapine results in decreased expression of NUP54 protein

NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Clozapine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

oxysterol binding protein-like 8

increases expression

ISO

Clozapine results in increased expression of OSBPL8 mRNA

NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151

G

oxytocin/neurophysin I prepropeptide

affects response to substance

ISO

OXT protein affects the susceptibility to Clozapine

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594

G

paralemmin A kinase anchor protein

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein

NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656

G

pantothenate kinase 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein

NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015

G

Parkinsonism associated deglycase

increases expression

ISO

Clozapine results in increased expression of PARK7 mRNA

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly(rC) binding protein 1

increases expression

ISO

Clozapine results in increased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

decreases expression

ISO

Clozapine results in decreased expression of PCK2 protein

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

piccolo (presynaptic cytomatrix protein)

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein

NCBI chr 4:20,646,604...21,005,171
Ensembl chr 4:20,646,604...21,005,111

G

pericentriolar material 1

decreases expression

ISO

Clozapine results in decreased expression of PCM1 mRNA

NCBI chr16:57,711,833...57,808,842
Ensembl chr16:57,711,833...57,808,599

G

PEST proteolytic signal containing nuclear protein

increases expression

ISO

Clozapine results in increased expression of PCNP protein

NCBI chr11:58,061,885...58,076,436
Ensembl chr11:58,061,570...58,076,436

G

proprotein convertase subtilisin/kexin type 1 inhibitor

affects expression

ISO

Clozapine affects the expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:17,251,965...17,257,360

G

programmed cell death 11

increases expression

ISO

Clozapine results in increased expression of PDCD11 protein

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

phosphodiesterase 10A

increases expression

ISO
EXP

Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein

PMID:17266109 PMID:18222493

NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051

G

phosphodiesterase 1B

increases expression

ISO

Clozapine results in increased expression of PDE1B mRNA

NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033

G

phosphodiesterase 4A

decreases expression

EXP

Clozapine results in decreased expression of PDE4A protein

NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924

G

phosphodiesterase 4B

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein

PMID:18222493 PMID:20222156

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

protein disulfide isomerase family A, member 3

decreases expression

ISO

Clozapine results in decreased expression of PDIA3 protein

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 4

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein

NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191

G

PDZ and LIM domain 5

decreases expression

ISO

Clozapine results in decreased expression of PDLIM5 protein

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Clozapine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

proenkephalin

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA

PMID:1635659 PMID:12887421

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

prefoldin subunit 5

increases expression

ISO

Clozapine results in increased expression of PFDN5 mRNA

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

phosphofructokinase, platelet

increases expression

EXP

Clozapine results in increased expression of PFKP mRNA

NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752

G

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

decreases expression

ISO

Clozapine results in decreased expression of PGAM5 protein

NCBI chr12:52,069,023...52,076,131
Ensembl chr12:52,069,103...52,076,131

G

phosphoglycerate kinase 1

increases expression

EXP

Clozapine results in increased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

progesterone receptor membrane component 1

multiple interactions

EXP

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

phosphatase and actin regulator 1

increases expression

ISO

Clozapine results in increased expression of PHACTR1 mRNA

NCBI chr17:21,769,006...22,246,227
Ensembl chr17:21,768,662...22,244,586

G

PHD finger protein 14

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

EXP

Clozapine results in decreased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

phosphatidylinositol transfer protein, beta

increases expression

ISO

Clozapine results in increased expression of PITPNB protein

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140

G

cAMP-dependent protein kinase inhibitor beta

decreases expression

EXP

Clozapine results in decreased expression of PKIB mRNA

NCBI chr20:37,511,564...37,608,607
Ensembl chr20:37,512,822...37,608,401

G

pyruvate kinase M1/2

increases expression

EXP

Clozapine results in increased expression of PKM mRNA

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase C beta 1

increases expression

ISO

Clozapine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

proteolipid protein 1

decreases expression
increases expression

ISO

Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA

PMID:17266109 PMID:18797397

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:104,975,780...104,993,314

G

plastin 3

decreases expression

ISO

Clozapine results in decreased expression of PLS3 protein

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

PNMA family member 1

increases expression

ISO

Clozapine results in increased expression of PNMA1 protein

NCBI chr 6:109,513,382...109,515,167
Ensembl chr 6:109,507,773...109,515,451

G

paraoxonase 3

increases expression

ISO

Clozapine results in increased expression of PON3 protein

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

inorganic pyrophosphatase 1

increases expression

ISO

Clozapine results in increased expression of PPA1 protein

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

decreases expression

EXP

Clozapine results in decreased expression of PPM1A mRNA

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

EXP

Clozapine results in decreased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase 1 catalytic subunit beta

decreases expression

EXP

Clozapine results in decreased expression of PPP1CB mRNA

NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924

G

protein phosphatase 1 catalytic subunit gamma

decreases expression

EXP

Clozapine results in decreased expression of PPP1CC mRNA

NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

decreases expression

ISO

Clozapine results in decreased expression of PPP1R14B protein

NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

decreases expression

EXP

Clozapine results in decreased expression of PPP1R1A mRNA

NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:136,523,604...136,540,683

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions
increases phosphorylation

ISO

Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein

PMID:11880652 PMID:12871586

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

decreases expression

EXP

Clozapine results in decreased expression of PPP1R2 mRNA

NCBI chr11:82,977,634...82,999,426
Ensembl chr11:82,977,515...83,001,083

G

protein phosphatase 1, regulatory subunit 9B

increases expression

EXP

Clozapine results in increased expression of PPP1R9B protein

NCBI chr10:80,434,888...80,450,919
Ensembl chr10:80,434,900...80,450,919

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

EXP

Clozapine results in decreased expression of PPP2CA mRNA

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 catalytic subunit beta

decreases expression

EXP

Clozapine results in decreased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

EXP

Clozapine results in increased expression of PPP2R1A mRNA

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242

G

protein phosphatase 2, regulatory subunit B, alpha

decreases expression

EXP

Clozapine results in decreased expression of PPP2R2A mRNA

NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions
increases expression
decreases expression

EXP

[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein

PMID:12437575 PMID:16033416

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

protein phosphatase 4, regulatory subunit 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein

NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844

G

protein phosphatase 5, catalytic subunit

affects expression

ISO

Clozapine affects the expression of PPP5C mRNA

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

peroxiredoxin 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein kinase cAMP-activated catalytic subunit alpha

increases expression

EXP

Clozapine results in increased expression of PRKACA mRNA

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase cAMP-activated catalytic subunit beta

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA

PMID:11907174 PMID:15860345

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions
decreases expression

EXP
ISO

Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein

PMID:11907174 PMID:34122009

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

protein kinase cAMP-dependent type II regulatory subunit beta

decreases expression
multiple interactions

EXP

Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]

PMID:11907174 PMID:15860345

NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411

G

protein kinase C, beta

affects expression
increases expression

EXP

Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA

PMID:15860345 PMID:15967061

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, epsilon

increases expression

EXP

Clozapine results in increased expression of PRKCE mRNA

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, zeta

increases expression

EXP

Clozapine results in increased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

prolactin

increases secretion
increases expression
multiple interactions

ISO
EXP

Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein

PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein arginine methyltransferase 1

decreases expression

ISO

Clozapine results in decreased expression of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

protein C, inactivator of coagulation factors Va and VIIIa

increases expression

ISO

Clozapine results in increased expression of PROC protein

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

pre-mRNA processing factor 38B

decreases expression

ISO

Clozapine results in decreased expression of PRPF38B mRNA

NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:199,241,313...199,250,338

G

pre-mRNA processing factor 6

decreases expression
multiple interactions

ISO

Clozapine results in decreased expression of PRPF6 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein

NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:189,081,794...189,152,786

G

proline-rich coiled-coil 2A

decreases expression

ISO

Clozapine results in decreased expression of PRRC2A mRNA

NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778

G

proteasome 20S subunit beta 5

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379

G

proteasome 20S subunit beta 7

decreases expression

ISO

Clozapine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601

G

proteasome 26S subunit, ATPase 3

increases expression

ISO

Clozapine results in increased expression of PSMC3 protein

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 5

increases expression

ISO

Clozapine results in increased expression of PSMC5 protein

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 14

increases expression

ISO

Clozapine results in increased expression of PSMD14 protein

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665

G

proteasome 26S subunit, non-ATPase 7

increases expression

ISO

Clozapine results in increased expression of PSMD7 protein

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

Pentatricopeptide repeat domain 3

increases expression

ISO

Clozapine results in increased expression of PTCD3 protein

NCBI chr 4:105,480,699...105,508,007
Ensembl chr 4:105,480,709...105,513,276

G

prostaglandin D2 synthase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA

PMID:15542763 PMID:17266109

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978

G

protein tyrosine kinase 2

increases expression

ISO

Clozapine results in increased expression of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

prothymosin alpha

increases expression

ISO

Clozapine results in increased expression of PTMA protein

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

parathymosin

increases expression

ISO

Clozapine results in increased expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

parvalbumin

multiple interactions

EXP

Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]

NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446

G

PWP2, small subunit processome component

increases expression

ISO

Clozapine results in increased expression of PWP2 protein

NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,013...10,513,309

G

pyrroline-5-carboxylate reductase 1

increases expression

ISO

Clozapine results in increased expression of PYCR1 protein

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

quinoid dihydropteridine reductase

decreases expression

ISO

Clozapine results in decreased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:69,882,612...69,896,379

G

RAB12, member RAS oncogene family

decreases expression

EXP

Clozapine results in decreased expression of RAB12 mRNA

NCBI chr 9:113,927,119...113,953,722
Ensembl chr 9:113,927,119...113,953,695

G

Rac family small GTPase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

receptor for activated C kinase 1

decreases expression

ISO

Clozapine results in decreased expression of RACK1 protein

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948

G

RALY RNA binding protein-like

increases expression

ISO

Clozapine results in increased expression of RALYL protein

NCBI chr 2:89,390,212...90,181,681
Ensembl chr 2:89,390,129...90,181,624

G

RAN, member RAS oncogene family

decreases expression

ISO

Clozapine results in decreased expression of RAN protein

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

Rap1 GTPase-GDP dissociation stimulator 1

increases expression

ISO

Clozapine results in increased expression of RAP1GDS1 protein

NCBI chr 2:230,173,713...230,318,555
Ensembl chr 2:230,173,713...230,318,538

G

Rap guanine nucleotide exchange factor 4

decreases expression

ISO

Clozapine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

EXP

Clozapine affects the expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

RB binding protein 4, chromatin remodeling factor

decreases expression

ISO

Clozapine results in decreased expression of RBBP4 protein

NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:146,922,611...146,959,501

G

RELA proto-oncogene, NF-kB subunit

decreases expression

EXP

Clozapine results in decreased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reelin

decreases expression
multiple interactions
decreases methylation

ISO
EXP

Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]

PMID:17266109 PMID:18757738 PMID:19359144

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

replication factor C subunit 5

increases expression

ISO

Clozapine results in increased expression of RFC5 protein

NCBI chr12:44,868,322...44,877,879
Ensembl chr12:44,862,329...44,878,151

G

regulator of G-protein signaling 4

increases expression

EXP
ISO

Clozapine results in increased expression of RGS4 mRNA

PMID:15860345 PMID:17266109

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

regulator of G-protein signaling 7

multiple interactions
increases expression

EXP

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA

NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987

G

regulator of G-protein signaling 8

increases expression

EXP

Clozapine results in increased expression of RGS8 mRNA

NCBI chr13:68,355,078...68,399,412
Ensembl chr13:68,355,157...68,399,412

G

ras homolog family member B

increases expression

ISO

Clozapine results in increased expression of RHOB protein

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

RIC8 guanine nucleotide exchange factor A

decreases expression

ISO

Clozapine results in decreased expression of RIC8A protein

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102

G

ring finger protein 13

increases expression

ISO

Clozapine results in increased expression of RNF13 protein

NCBI chr 2:144,076,526...144,211,520
Ensembl chr 2:144,077,916...144,211,798

G

ring finger protein 20

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein

NCBI chr 5:68,771,507...68,797,240
Ensembl chr 5:68,771,535...68,797,240

G

RAR-related orphan receptor B

decreases expression

EXP

Clozapine results in decreased expression of RORB mRNA

NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973

G

replication protein A1

decreases expression

ISO

Clozapine results in decreased expression of RPA1 protein

NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279

G

ribosomal protein L11

increases expression

ISO

Clozapine results in increased expression of RPL11 protein

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L19

increases expression

ISO

Clozapine results in increased expression of RPL19 protein

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L30

increases expression

ISO

Clozapine results in increased expression of RPL30 protein

NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555

G

ribosomal protein L5

increases expression

ISO

Clozapine results in increased expression of RPL5 protein

NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225

G

ribosomal protein lateral stalk subunit P0 like 1

decreases expression

ISO

Clozapine results in decreased expression of RPLP0P6 protein

NCBI chr 2:194,609,881...194,611,022
Ensembl chr 2:194,609,950...194,611,022

G

ribosomal protein lateral stalk subunit P2

increases expression

ISO

Clozapine results in increased expression of RPLP2 mRNA

NCBI chr 1:205,975,598...205,978,192
Ensembl chr 1:205,975,894...205,978,191

G

ribophorin II

decreases expression

ISO

Clozapine results in decreased expression of RPN2 protein

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S10

increases expression

ISO

Clozapine results in increased expression of RPS10 mRNA

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S11

decreases expression

ISO

Clozapine results in decreased expression of RPS11 protein

NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:104,742,155...104,744,337

G

ribosomal protein S3

decreases expression

ISO

Clozapine results in decreased expression of RPS3 protein

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776

G

ribosome binding protein 1

decreases expression

ISO

Clozapine results in decreased expression of RRBP1 protein

NCBI chr 3:151,768,386...151,830,255
Ensembl chr 3:151,768,386...151,830,255

G

remodeling and spacing factor 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein

NCBI chr 1:161,303,596...161,426,326
Ensembl chr 1:161,303,660...161,420,290

G

ring finger and SPRY domain containing 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein

NCBI chr19:10,358,423...10,408,988
Ensembl chr19:10,359,795...10,407,076

G

RT1 class Ia, locus A2

increases expression

ISO

Clozapine results in increased expression of HLA-E protein

NCBI chr20:4,872,720...4,876,425

G

RNA 2',3'-cyclic phosphate and 5'-OH ligase

increases expression

ISO

Clozapine results in increased expression of RTCB protein

NCBI chr 7:19,795,393...19,814,875
Ensembl chr 7:19,795,393...19,814,875

G

reticulon 4

increases expression

ISO

Clozapine results in increased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611

G

retinoid X receptor gamma

decreases expression

EXP

Clozapine results in decreased expression of RXRG mRNA alternative form

NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095

G

S100 calcium binding protein A9

decreases expression

ISO

Clozapine results in decreased expression of S100A9 mRNA

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

scaffold attachment factor B

increases expression

ISO

Clozapine results in increased expression of SAFB protein

NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781

G

seryl-tRNA synthetase 1

decreases expression

ISO

Clozapine results in decreased expression of SARS1 protein

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

SATB homeobox 2

increases expression

ISO

Clozapine results in increased expression of SATB2 protein

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238

G

sterol-C5-desaturase

increases expression

ISO

Clozapine results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

stearoyl-CoA desaturase

increases expression

ISO

Clozapine results in increased expression of SCD mRNA

PMID:16027736 PMID:17052361

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

syndecan binding protein

decreases expression
increases expression

ISO

Clozapine results in decreased expression of SDCBP protein
Clozapine results in increased expression of SDCBP protein

PMID:34122009 PMID:36482696

NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:24,245,033...24,326,197

G

secretory blood group 1

decreases expression
increases expression

EXP

Clozapine results in decreased expression of SEC1 mRNA
Clozapine results in increased expression of SEC1 mRNA

NCBI chr 1:105,287,093...105,301,588
Ensembl chr 1:105,287,443...105,301,793

G

SEC31 homolog A, COPII coat complex component

increases expression

ISO

Clozapine results in increased expression of SEC31A protein

NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,518,648...9,573,585

G

SEC61 translocon subunit beta

increases expression

ISO

Clozapine results in increased expression of SEC61B protein

NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028

G

SEC63 homolog, protein translocation regulator

increases expression

ISO

Clozapine results in increased expression of SEC63 protein

NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248

G

septin 14

decreases expression

ISO

Clozapine results in decreased expression of SEPTIN14 protein

NCBI chr12:32,610,600...32,641,391
Ensembl chr12:32,611,434...32,641,391

G

serine incorporator 1

increases expression

ISO

Clozapine results in increased expression of SERINC1 protein

NCBI chr20:37,396,497...37,415,433
Ensembl chr20:37,396,497...37,443,124

G

serpin family A member 3N

increases expression

ISO

Clozapine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family E member 2

increases expression

EXP

Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

Set nuclear proto-oncogene

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SET protein

NCBI chr 3:33,732,319...33,743,433

G

senataxin

increases expression

ISO

Clozapine results in increased expression of SETX protein

NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740

G

splicing factor 3b, subunit 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein

NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621

G

splicing factor proline and glutamine rich

decreases expression

ISO

Clozapine results in decreased expression of SFPQ protein

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926

G

sideroflexin 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

serum/glucocorticoid regulated kinase 1

increases expression

ISO
EXP

Clozapine results in increased expression of SGK1 mRNA

PMID:17266109 PMID:18208916

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

SH3 domain containing GRB2 like 1, endophilin A2

increases expression

ISO

Clozapine results in increased expression of SH3GL1 protein

NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890

G

SH3 domain-containing kinase-binding protein 1

increases expression

ISO

Clozapine results in increased expression of SH3KBP1 protein

NCBI chr X:38,686,530...39,031,658
Ensembl chr X:38,686,530...39,031,393

G

SH3 and PX domains 2B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854

G

SIM bHLH transcription factor 2

decreases expression

ISO

Clozapine results in decreased expression of SIM2 protein

NCBI chr11:46,883,859...46,923,305
Ensembl chr11:46,883,859...46,923,305

G

sirtuin 2

increases expression

ISO

Clozapine results in increased expression of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499

G

S-phase kinase-associated protein 1

decreases expression

ISO

Clozapine results in decreased expression of SKP1 protein

NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308

G

solute carrier family 17 member 6

increases expression

ISO

Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein

PMID:17266109 PMID:18155072

NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498

G

solute carrier family 17 member 7

increases expression

ISO

Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 18 member A2

increases expression

EXP

Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 1

decreases expression

EXP

Clozapine results in decreased expression of SLC1A1 mRNA

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469

G

solute carrier family 1 member 2

decreases activity
decreases expression

EXP

Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein

PMID:11443521 PMID:12873733

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 22 member 2

multiple interactions

ISO

Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

ISO

Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 25 member 13

increases expression

ISO

Clozapine results in increased expression of SLC25A13 protein

NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 24

increases expression

ISO

Clozapine results in increased expression of SLC25A24 protein

NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290

G

solute carrier family 25 member 5, pseudogene 11

increases expression

ISO

Clozapine results in increased expression of SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 2 member 3

decreases expression

ISO

Clozapine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 39 member 7

increases expression

ISO

Clozapine results in increased expression of SLC39A7 mRNA

NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,824,688...4,828,430

G

solute carrier family 3 member 2

increases expression

ISO

Clozapine results in increased expression of SLC3A2 protein

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 2

decreases expression

EXP

Clozapine results in decreased expression of SLC6A2 mRNA

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 6 member 3

affects response to substance

ISO

SLC6A3 5' UTR affects the susceptibility to Clozapine

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

multiple interactions
increases expression
affects response to substance

ISO
EXP

[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine

PMID:12007678 PMID:20452607

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier organic anion transporter family member 1B2

decreases activity

ISO

Clozapine results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Clozapine results in decreased expression of SMARCB1 protein

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

SWI/SNF related BAF chromatin remodeling complex subunit C2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein

NCBI chr 7:1,466,223...1,494,627
Ensembl chr 7:1,466,454...1,494,626

G

structural maintenance of chromosomes 2

decreases expression

ISO

Clozapine results in decreased expression of SMC2 protein

NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:71,602,308...71,648,632

G

structural maintenance of chromosomes 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

synaptosome associated protein 25

increases expression
affects response to substance

EXP
ISO

Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine

PMID:15823421 PMID:15860345

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448

G

small nuclear ribonucleoprotein U5 subunit 200

increases expression

ISO

Clozapine results in increased expression of SNRNP200 protein

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

small nuclear ribonucleoprotein polypeptides B and B1

increases expression

ISO

Clozapine results in increased expression of SNRPB protein

NCBI chr 3:137,824,870...137,832,479
Ensembl chr 3:137,824,683...137,832,515

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

ISO

Clozapine results in increased expression of SNRPD2 mRNA

NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:87,926,048...87,933,339
Ensembl chr20:87,926,048...87,933,339

G

sorting nexin 1

decreases expression

ISO

Clozapine results in decreased expression of SNX1 protein

NCBI chr 8:75,515,780...75,565,487
Ensembl chr 8:75,525,181...75,565,561

G

sorting nexin 6

increases expression

ISO

Clozapine results in increased expression of SNX6 protein

NCBI chr 6:77,966,141...78,009,343
Ensembl chr 6:77,965,819...78,051,290

G

superoxide dismutase 1

increases expression
decreases expression
multiple interactions

EXP
ISO

Clozapine results in increased expression of SOD1 mRNA
Clozapine results in decreased expression of SOD1 protein
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]

PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

decreases expression

EXP

Clozapine results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

increases expression

EXP

Clozapine results in increased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression
increases expression

EXP

Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

secreted phosphoprotein 1

decreases expression

ISO

Clozapine results in decreased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

serine palmitoyltransferase, long chain base subunit 1

decreases expression

ISO

Clozapine results in decreased expression of SPTLC1 protein

NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234

G

sequestosome 1

increases expression

ISO

Clozapine results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

increases expression
multiple interactions

ISO

Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]

PMID:17052361 PMID:19682446 PMID:20564506

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression

ISO

Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

serine/arginine repetitive matrix 2

decreases expression

ISO

Clozapine results in decreased expression of SRRM2 protein

NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337

G

serine and arginine rich splicing factor 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

serine and arginine rich splicing factor 5

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 7

decreases expression

ISO

Clozapine results in decreased expression of SRSF7 protein

NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212

G

signal sequence receptor subunit 3

decreases expression

ISO

Clozapine results in decreased expression of SSR3 protein

NCBI chr 2:151,915,101...151,935,162
Ensembl chr 2:151,906,149...151,935,170

G

somatostatin

multiple interactions

EXP

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

stromal interaction molecule 1

decreases expression

ISO

Clozapine results in decreased expression of STIM1 protein

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108

G

stress-induced phosphoprotein 1

decreases expression

ISO

Clozapine results in decreased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

serine/threonine kinase receptor associated protein

decreases expression

ISO

Clozapine results in decreased expression of STRAP protein

NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436

G

striatin 4

increases expression

ISO

Clozapine results in increased expression of STRN4 mRNA

NCBI chr 1:86,614,193...86,639,959
Ensembl chr 1:86,610,210...86,639,955

G

syntaxin 1A

increases expression

EXP

Clozapine results in increased expression of STX1A mRNA

NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471

G

syntaxin 1B

increases expression

EXP

Clozapine results in increased expression of STX1B mRNA

NCBI chr 1:191,846,016...191,864,878
Ensembl chr 1:191,833,743...191,871,633

G

syntaxin 4

increases expression

EXP

Clozapine results in increased expression of STX4 mRNA

NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774

G

syntaxin 8

affects expression

EXP

Clozapine affects the expression of STX8 mRNA

NCBI chr10:53,154,572...53,393,912
Ensembl chr10:53,153,523...53,429,541

G

syntaxin binding protein 1

affects expression

EXP

Clozapine affects the expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058

G

succinate-CoA ligase ADP-forming subunit beta

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

ISO

Clozapine results in decreased expression of SUCLG1 protein

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

SPT3 homolog, SAGA and STAGA complex component

increases expression

EXP

Clozapine results in increased expression of SUPT3H mRNA

NCBI chr 9:23,375,889...23,704,229
Ensembl chr 9:23,376,136...23,704,466

G

synapsin II

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA

PMID:15860345 PMID:17266109

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

ISO

Clozapine results in decreased expression of SYNCRIP protein

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

synaptotagmin 11

increases expression

EXP

Clozapine results in increased expression of SYT11 mRNA

NCBI chr 2:176,503,845...176,530,354
Ensembl chr 2:176,503,845...176,529,775

G

synaptotagmin 2

increases expression

ISO

Clozapine results in increased expression of SYT2 mRNA

NCBI chr13:48,639,634...48,749,814
Ensembl chr13:48,639,934...48,749,812

G

synaptotagmin 4

increases expression

EXP

Clozapine results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815

G

synaptotagmin 5

decreases expression

EXP

Clozapine results in decreased expression of SYT5 mRNA

NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746

G

tachykinin, precursor 1

decreases expression

ISO
EXP

Clozapine results in decreased expression of TAC1 mRNA

PMID:10974607 PMID:17266109

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

transgelin

decreases expression

ISO

Clozapine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17175557

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

transgelin 2

decreases expression

ISO

Clozapine results in decreased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330

G

TAO kinase 2

increases expression

ISO

Clozapine results in increased expression of TAOK2 protein

NCBI chr 1:190,906,236...190,925,359
Ensembl chr 1:190,906,239...190,925,140

G

TatD DNase domain containing 1

increases expression

ISO

Clozapine results in increased expression of TATDN1 mRNA

NCBI chr 7:92,339,452...92,370,445
Ensembl chr 7:92,330,554...92,370,400

G

TBC1 domain family, member 15

increases expression

ISO

Clozapine results in increased expression of TBC1D15 protein

NCBI chr 7:52,690,770...52,746,309
Ensembl chr 7:52,690,770...52,746,303

G

TBC1 domain family member 8B

increases expression

ISO

Clozapine results in increased expression of TBC1D8B protein

NCBI chr X:108,107,796...108,195,744
Ensembl chr X:108,107,769...108,195,732

G

tubulin folding cofactor B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949

G

transducin (beta)-like 3

increases expression

ISO

Clozapine results in increased expression of TBL3 protein

NCBI chr10:14,230,660...14,235,873
Ensembl chr10:14,230,661...14,235,873

G

TRPM8 channel-associated factor 1

decreases expression

ISO

Clozapine results in decreased expression of TCAF1 protein

NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:72,589,710...72,639,475

G

testin LIM domain protein

decreases expression

ISO

Clozapine results in decreased expression of TES protein

NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780

G

trans-golgi network protein 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262

G

tyrosine hydroxylase

decreases activity
multiple interactions
increases expression
decreases expression
increases activity

EXP
ISO

Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine

PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

thyroid hormone receptor alpha

decreases expression
increases expression

EXP

Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor associated protein 3

decreases expression

ISO

Clozapine results in decreased expression of THRAP3 protein

NCBI chr 5:143,729,821...143,772,105
Ensembl chr 5:143,730,596...143,771,983

G

thyroid hormone receptor beta

decreases expression

EXP

Clozapine results in decreased expression of THRB mRNA alternative form

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

talin 2

decreases expression

ISO

Clozapine results in decreased expression of TLN2 protein

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

transmembrane 9 superfamily member 2

decreases expression

ISO

Clozapine results in decreased expression of TM9SF2 protein

NCBI chr15:105,606,082...105,660,715
Ensembl chr15:105,606,118...105,660,714

G

transmembrane p24 trafficking protein 10

decreases expression

ISO

Clozapine results in decreased expression of TMED10 protein

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:110,722,889...110,757,777

G

transmembrane protein 109

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein

NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138

G

thymopoietin

decreases expression

ISO

Clozapine results in decreased expression of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

tumor necrosis factor

affects response to substance
increases secretion
multiple interactions
increases expression

ISO
EXP

TNF protein affects the susceptibility to Clozapine
Clozapine results in increased secretion of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]
Clozapine results in increased expression of TNF protein

PMID:20521320 PMID:24709159 PMID:34935985

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 15

decreases expression

ISO

Clozapine results in decreased expression of TNFSF15 mRNA

NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882

G

TRAF2 and NCK interacting kinase

decreases expression

ISO

Clozapine results in decreased expression of TNIK mRNA

NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:113,112,938...113,511,339

G

DNA topoisomerase I mitochondrial

increases expression

ISO

Clozapine results in increased expression of TOP1MT protein

NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799

G

tumor protein p53

increases expression
multiple interactions

ISO

Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

triosephosphate isomerase 1

increases expression

EXP

Clozapine results in increased expression of TPI1 mRNA

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tropomyosin 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

tropomyosin 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

tropomyosin 4

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

translocated promoter region, nuclear basket protein

decreases expression

ISO

Clozapine results in decreased expression of TPR protein

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

transformer 2 beta

decreases expression

ISO

Clozapine results in decreased expression of TRA2B protein

NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781

G

tripartite motif-containing 2

decreases expression

ISO

Clozapine results in decreased expression of TRIM2 mRNA

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468

G

tripartite motif-containing 28

decreases expression

ISO

Clozapine results in decreased expression of TRIM28 protein

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tetraspanin 3

decreases expression
increases expression

ISO

Clozapine results in decreased expression of TSPAN3 protein
Clozapine results in increased expression of TSPAN3 protein

PMID:34122009 PMID:36482696

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

tau tubulin kinase 1

increases expression

ISO

Clozapine results in increased expression of TTBK1 protein

NCBI chr 9:21,990,973...22,035,961
Ensembl chr 9:21,990,973...22,035,961

G

transthyretin

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein

PMID:15927202 PMID:17266109

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

tweety family member 2

increases expression

ISO

Clozapine results in increased expression of TTYH2 protein

NCBI chr10:100,208,129...100,252,505
Ensembl chr10:100,207,860...100,253,521

G

tubulin, alpha-like 3

increases expression

ISO

Clozapine results in increased expression of TUBAL3 protein

NCBI chr17:71,233,194...71,245,297
Ensembl chr17:71,232,851...71,245,337

G

tubulin, beta 4B class IVb

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719

G

tubulin, beta 5 class I

increases expression

ISO

Clozapine results in increased expression of TUBB protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

tubulin, beta 6 class V

decreases expression

ISO

Clozapine results in decreased expression of TUBB6 protein

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

increases expression

ISO

Clozapine results in increased expression of UAP1L1 protein

NCBI chr 3:28,570,854...28,579,766
Ensembl chr 3:28,573,358...28,578,630

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901

G

ubiquitin A-52 residue ribosomal protein fusion product 1

increases expression

ISO

Clozapine results in increased expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin-conjugating enzyme E2R 2

affects expression

ISO

Clozapine affects the expression of UBE2R2 mRNA

NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452

G

upstream binding transcription factor

decreases expression

ISO

Clozapine results in decreased expression of UBTF protein

NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088

G

UDP glucuronosyltransferase family 1 member A1

increases expression

ISO

Clozapine results in increased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation

ISO

UGT1A4 protein SNP results in increased glucuronidation of Clozapine

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-13 homolog A

decreases expression

EXP

Clozapine results in decreased expression of UNC13A mRNA

NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899

G

unc-45 myosin chaperone B

increases expression

ISO

Clozapine results in increased expression of UNC45B protein

NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

ISO

Clozapine affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

ubiquitin specific peptidase 34

increases expression

ISO

Clozapine results in increased expression of USP34 protein

NCBI chr14:101,487,110...101,677,519
Ensembl chr14:101,487,153...101,678,632

G

ubiquitin specific peptidase 5

increases expression

ISO

Clozapine results in increased expression of USP5 protein

NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:159,305,938...159,320,956

G

UTP18 small subunit processome component

increases expression

ISO

Clozapine results in increased expression of UTP18 protein

NCBI chr10:79,308,785...79,336,241
Ensembl chr10:79,308,787...79,336,197

G

vesicle-associated membrane protein 1

increases expression

EXP

Clozapine results in increased expression of VAMP1 mRNA

NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:159,698,629...159,713,608

G

vesicle-associated membrane protein 2

increases expression

EXP

Clozapine results in increased expression of VAMP2 mRNA

NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654

G

VAMP associated protein A

increases expression

ISO

Clozapine results in increased expression of VAPA protein

NCBI chr 9:112,624,791...112,654,731
Ensembl chr 9:112,624,794...112,654,731

G

VAMP associated protein B and C

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of VAPB protein

NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619

G

vinculin

increases expression

ISO

Clozapine results in increased expression of VCL protein

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163

G

voltage-dependent anion channel 1

decreases expression

ISO

Clozapine results in decreased expression of VDAC1 protein

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

visinin-like 1

decreases expression

EXP

Clozapine results in decreased expression of VSNL1 mRNA

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556

G

tryptophanyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of WARS1 protein

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WW domain binding protein 1-like

decreases expression

ISO

Clozapine results in decreased expression of WBP1L mRNA

NCBI chr 1:255,413,701...255,470,026
Ensembl chr 1:255,413,524...255,470,026

G

WD repeat domain 12

decreases expression

ISO

Clozapine results in decreased expression of WDR12 protein

NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811

G

WD repeat domain, phosphoinositide interacting 1

increases expression

ISO

Clozapine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

ISO

Clozapine results in decreased expression of YWHAB mRNA

NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

ISO

Clozapine results in increased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875

G

zinc finger CCCH-type containing, antiviral 1

decreases expression

ISO

Clozapine results in decreased expression of ZC3HAV1 protein

NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,979,055...68,029,353

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

Cyclizine results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2-associated agonist of cell death

increases expression

ISO

Cyclizine results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2, apoptosis regulator

decreases expression

ISO

Cyclizine results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases activity

ISO

Cyclizine results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

Cyclizine results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

Cyclizine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

CD14 molecule

increases expression

ISO

Cyclizine results in increased expression of CD14 protein

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

Fas cell surface death receptor

increases expression

ISO

Cyclizine results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

intercellular adhesion molecule 1

increases expression

ISO

Cyclizine results in increased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 1 beta

increases secretion

ISO

Cyclizine results in increased secretion of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases secretion

ISO

Cyclizine results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha M

increases expression

ISO

Cyclizine results in increased expression of ITGAM protein

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

nitric oxide synthase 2

increases expression

ISO

Cyclizine results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

protein tyrosine phosphatase, receptor type, C

increases expression

ISO

Cyclizine results in increased expression of PTPRC protein

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

ISO

Cyclizine results in increased phosphorylation of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

increases secretion

ISO

Cyclizine results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression

EXP

Cyproheptadine results in increased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

Cyproheptadine results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

growth hormone 1

increases expression

ISO

Cyproheptadine results in increased expression of GH1 protein

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

heat shock transcription factor 1

increases activity

ISO

Cyproheptadine results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

5-hydroxytryptamine receptor 2A

multiple interactions

ISO

Cyproheptadine binds to and results in decreased activity of HTR2A protein

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

ISO

Cyproheptadine binds to HTR7 protein
Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230

G

interleukin 6

decreases expression

EXP

Cyproheptadine results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

potassium calcium-activated channel subfamily N member 2

decreases activity

EXP

Cyproheptadine results in decreased activity of KCNN2 protein

NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045

G

nuclear factor kappa B subunit 1

decreases expression

EXP

Cyproheptadine results in decreased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

proopiomelanocortin

decreases secretion

ISO

Cyproheptadine results in decreased secretion of POMC protein

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

prolactin

decreases secretion

ISO

Cyproheptadine results in decreased secretion of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

sirtuin 1

increases expression

EXP

Cyproheptadine results in increased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 22 member 2

multiple interactions

ISO

Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

ISO

Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

dibenzheptropine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases activity

ISO

Desipramine results in increased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

actin alpha 2, smooth muscle

multiple interactions

ISO

Desipramine inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

alkaline phosphatase, placental

multiple interactions

ISO

Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451

G

activity-regulated cytoskeleton-associated protein

increases expression

EXP

Desipramine results in increased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

BCL2, apoptosis regulator

increases expression

EXP

Desipramine results in increased expression of BCL2 mRNA; Desipramine results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

increases expression

ISO

Desipramine results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

ISO

Desipramine results in decreased expression of CAMKK1 mRNA

NCBI chr10:58,135,872...58,159,023
Ensembl chr10:58,135,915...58,159,010

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

ISO

Desipramine results in decreased expression of CAMKK2 mRNA

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964

G

caspase 3

multiple interactions
increases activity

ISO
EXP

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased cleavage of and results in increased activity of CASP3 protein]; Desipramine results in increased cleavage of and results in increased activity of CASP3 protein
Desipramine results in increased activity of CASP3 protein

PMID:18606486 PMID:18986328 PMID:20549303

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases activity

EXP

Desipramine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 5

multiple interactions

ISO

Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cadherin 1

multiple interactions

ISO

Desipramine inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cAMP responsive element binding protein 1

increases expression

EXP

Desipramine results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

citrate synthase

multiple interactions

ISO

Desipramine inhibits the reaction [Glucose results in increased activity of CS protein]

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

Desipramine results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing

ISO

CYP2D6 protein affects the metabolism of Desipramine

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

Desipramine results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance
decreases activity

ISO

CYP3A4 protein results in increased susceptibility to Desipramine
Desipramine results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:21540358

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

dopamine beta-hydroxylase

increases response to substance

ISO

DBH protein results in increased susceptibility to Desipramine

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316

G

DNA-damage inducible transcript 3

affects response to substance
increases expression

EXP

DDIT3 affects the susceptibility to Desipramine
Desipramine results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

early growth response 1

decreases expression

EXP

Desipramine results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Desipramine results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

galanin and GMAP prepropeptide

multiple interactions

EXP

Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA]

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

G protein-coupled receptor kinase 2

affects localization

EXP

Desipramine affects the localization of GRK2 protein

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015

G

G protein-coupled receptor kinase 3

affects localization

EXP

Desipramine affects the localization of GRK3 protein

NCBI chr12:49,285,228...49,395,803
Ensembl chr12:49,285,263...49,395,802

G

5-hydroxytryptamine receptor 1A

multiple interactions
increases expression

ISO
EXP

Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]
Desipramine results in increased expression of HTR1A protein

PMID:1589591 PMID:15885359

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 2A

decreases expression

EXP

Desipramine results in decreased expression of HTR2A; Desipramine results in decreased expression of HTR2A protein

PMID:1664741 PMID:2553044

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interferon, alpha 1

multiple interactions

ISO

Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interleukin 1 beta

increases secretion

EXP

Desipramine results in increased secretion of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Desipramine results in decreased activity of KCNH2 protein

PMID:20211602 PMID:24052561

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

mitogen activated protein kinase 1

increases activity

ISO

Desipramine results in increased activity of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

increases activity

ISO

Desipramine results in increased activity of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

increases activity

ISO

Desipramine results in increased activity of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

nestin

increases expression

EXP

Desipramine results in increased expression of NES mRNA

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

NFE2 like bZIP transcription factor 2

affects response to substance

ISO

NFE2L2 protein affects the susceptibility to Desipramine

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

Desipramine inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

ISO

Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

phospholipase C beta 1

decreases expression

EXP

Desipramine results in decreased expression of PLCB1 mRNA; Desipramine results in decreased expression of PLCB1 protein

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

protein phosphatase 1, regulatory subunit 15A

increases expression

EXP

Desipramine results in increased expression of PPP1R15A protein

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

solute carrier family 16 member 2

multiple interactions

ISO

Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]

NCBI chr X:72,791,096...72,914,299
Ensembl chr X:72,781,876...72,914,498

G

solute carrier family 17 member 7

increases expression

ISO

Desipramine results in increased expression of SLC17A7 mRNA; Desipramine results in increased expression of SLC17A7 protein

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 22 member 2

multiple interactions

ISO

Desipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

EXP
ISO

Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]

PMID:9830022 PMID:10966924

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 7

multiple interactions

ISO

Desipramine inhibits the reaction [SLC22A7 protein results in increased uptake of Rhodamine 123]

NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681

G

solute carrier family 6 member 2

multiple interactions
decreases activity
decreases expression

ISO
EXP

Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]
Desipramine results in decreased activity of SLC6A2 protein
Desipramine results in decreased expression of SLC6A2 protein
[Desipramine binds to and results in decreased activity of SLC6A2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; [Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]

PMID:16725121 PMID:17234900 PMID:18561912 PMID:18923402 PMID:19616025 More...

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

sphingomyelin phosphodiesterase 1

decreases activity

ISO

Desipramine results in decreased activity of SMPD1 protein

NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614

G

trace-amine-associated receptor 1

multiple interactions

ISO

Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]

NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981

G

tachykinin, precursor 1

decreases expression

EXP

Desipramine results in decreased expression of TAC1 protein

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

tyrosine hydroxylase

multiple interactions

EXP

Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

decreases activity
multiple interactions

ISO

Desipramine results in decreased activity of TNF protein
Desipramine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein]

PMID:17477857 PMID:24951586

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ISO

ABCB1 protein results in increased export of desloratadine

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

angiotensin converting enzyme 2

affects binding

ISO

desloratadine binds to ACE2 protein

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

alkaline phosphatase, biomineralization associated

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

BCL2, apoptosis regulator

decreases expression

ISO

desloratadine results in decreased expression of BCL2 mRNA; desloratadine results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases cleavage

ISO

desloratadine results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cyclin B1

decreases expression

ISO

desloratadine results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin-dependent kinase 1

increases phosphorylation

ISO

desloratadine results in increased phosphorylation of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects chemical synthesis

ISO

CYP2D6 protein affects the chemical synthesis of desloratadine

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

coagulation factor III, tissue factor

increases expression

ISO

desloratadine results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

gamma-glutamyltransferase 1

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

hippocalcin-like 1

affects response to substance
decreases expression
decreases myristoylation
multiple interactions

ISO

HPCAL1 protein affects the susceptibility to desloratadine
desloratadine results in decreased expression of HPCAL1 protein
desloratadine results in decreased myristoylation of HPCAL1 protein
Ammonium Chloride inhibits the reaction [desloratadine results in increased degradation of HPCAL1 protein]; desloratadine results in decreased expression of and results in increased degradation of HPCAL1 protein

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

histamine receptor H 1

affects binding

ISO

desloratadine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 1 beta

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 5

multiple interactions

ISO

[montelukast co-treated with desloratadine] results in decreased expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions

ISO

desloratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein

PMID:28551711 PMID:29143966

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

mitogen activated protein kinase kinase kinase 7

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of TAK1 protein]

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012

G

MYD88, innate immune signal transduction adaptor

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

N-myristoyltransferase 1

affects response to substance
multiple interactions

ISO

NMT1 protein affects the susceptibility to desloratadine
desloratadine binds to and results in decreased activity of NMT1 protein

NCBI chr10:88,488,918...88,525,496
Ensembl chr10:88,488,990...88,522,729

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

[desloratadine results in increased susceptibility to Sorafenib] which results in increased cleavage of PARP1 protein; [Sorafenib results in increased susceptibility to desloratadine] which results in increased cleavage of PARP1 protein
desloratadine results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

RELA proto-oncogene, NF-kB subunit

decreases phosphorylation
multiple interactions

ISO
EXP

desloratadine results in decreased phosphorylation of RELA protein
desloratadine inhibits the reaction [Thioacetamide results in increased expression of RELA protein]

PMID:36617552 PMID:39672344

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 22 member 2

multiple interactions

ISO

desloratadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

transforming growth factor, beta 1

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

toll-like receptor 4

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

TNF receptor associated factor 6

multiple interactions

EXP

desloratadine inhibits the reaction [Thioacetamide results in increased expression of TRAF6 protein]

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

dexbrompheniramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

dexbrompheniramine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

dexbrompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

dexchlorpheniramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

ISO

dexchlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

ISO

Dimenhydrinate results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

solute carrier family 22 member 2

multiple interactions

ISO

Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

diphenhydramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 5

affects response to substance

ISO

ATG5 protein affects the susceptibility to Diphenhydramine

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

butyrylcholinesterase

multiple interactions
decreases activity

ISO

Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

bone morphogenetic protein 6

decreases expression

ISO

Diphenhydramine results in decreased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

epiregulin

decreases expression

ISO

Diphenhydramine results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

coagulation factor III, tissue factor

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

G protein subunit alpha i1

increases response to substance

ISO

GNAI1 results in increased susceptibility to Diphenhydramine

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

increases response to substance

ISO

GNAI2 results in increased susceptibility to Diphenhydramine

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

histamine receptor H 1

multiple interactions

ISO
EXP

Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin

PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More...

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 1 beta

increases expression
decreases expression

ISO

Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA

PMID:28138970 PMID:32816093

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

decreases expression

ISO

Diphenhydramine results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen-activated protein kinase 8

increases activity

ISO

Diphenhydramine results in increased activity of MAPK8

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

phospholipase A2 group 4A

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Diphenhydramine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 22 member 1

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16263091 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 5

multiple interactions

ISO

Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 7 member 11

decreases expression

ISO

Diphenhydramine results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Diphenhydramine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

diphenylpyraline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H 1

multiple interactions

ISO

diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

diphenylpyraline results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Doxylamine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

Doxylamine binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

emedastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects transport

ISO

ABCB1A affects the transport of epinastine

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

affects transport

ISO

ABCB1B affects the transport of epinastine

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

histamine receptor H 1

multiple interactions

EXP

[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]

PMID:12832840 PMID:19075512

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interferon gamma

multiple interactions

ISO

epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 13

decreases expression

ISO

epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 4

multiple interactions

ISO
EXP

epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]

PMID:16534218 PMID:19075512

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

decreases expression

ISO

epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

decreases expression

ISO

epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

epinastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

nerve growth factor

decreases expression

ISO

epinastine results in decreased expression of NGF protein

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

solute carrier family 22 member 2

multiple interactions

ISO

epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

ISO

Famotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids]

NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383

G

angiotensinogen

multiple interactions

EXP

Famotidine inhibits the reaction [Indomethacin results in increased expression of AGT protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

B-Raf proto-oncogene, serine/threonine kinase

decreases activity

ISO

Famotidine results in decreased activity of BRAF protein

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931

G

carbonic anhydrase 12

multiple interactions

ISO

Famotidine binds to and results in decreased activity of CA12 protein

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:76,169,815...76,225,465

G

carbonic anhydrase 6

multiple interactions

ISO

Famotidine binds to and results in decreased activity of CA6 protein

NCBI chr 5:165,941,028...165,959,566
Ensembl chr 5:165,941,029...165,959,566

G

carbonic anhydrase 2

multiple interactions

ISO

Famotidine binds to and results in decreased activity of CA2 protein

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

carbonic anhydrase 7

multiple interactions

ISO

Famotidine binds to and results in decreased activity of CA7 protein

NCBI chr19:435,520...444,927
Ensembl chr19:435,522...452,384

G

catalase

multiple interactions

EXP
ISO

Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]]
Famotidine inhibits the reaction [Indomethacin results in decreased expression of CAT protein]

PMID:18726076 PMID:19034656 PMID:19497431 PMID:25926722 PMID:38447874

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

Cd80 molecule

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

catenin beta 1

multiple interactions
increases expression

ISO

Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
Famotidine results in increased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine ligand 1

increases expression

EXP

Famotidine results in increased expression of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

ISO

Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

fibroblast growth factor 2

multiple interactions

ISO

[Famotidine co-treated with Sucralfate] results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor 21

increases expression

ISO

Famotidine results in increased expression of FGF21 protein

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

EXP

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit alpha 3

multiple interactions

EXP

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr X:155,301,979...155,543,870
Ensembl chr X:155,303,928...155,543,863

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

EXP

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171

G

gamma-aminobutyric acid type A receptor subunit gamma 1

multiple interactions

EXP

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]

NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,750,292...37,989,945

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

EXP

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523

G

gastrin

affects expression
increases expression

ISO
EXP

Famotidine affects the expression of GAST protein
Famotidine results in increased expression of GAST protein

PMID:12503773 PMID:17652263

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

ghrelin and obestatin prepropeptide

multiple interactions

EXP

Famotidine inhibits the reaction [GHRL protein results in increased secretion of Acids]

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

glycogen synthase kinase 3 beta

multiple interactions

ISO

Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

histamine receptor H 2

multiple interactions
decreases activity
increases expression

ISO
EXP

[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Famotidine binds to and results in decreased activity of HRH2 protein; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]
Famotidine results in decreased activity of HRH2 protein
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine
Famotidine results in increased expression of HRH2 protein

PMID:9187264 PMID:9681472 PMID:12832840 PMID:15961859 PMID:16632449 More...

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

EXP

Famotidine results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

intercellular adhesion molecule 1

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]

PMID:11752121 PMID:12364868 PMID:12538815

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]

PMID:11752121 PMID:12364868 PMID:19277450

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12A

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]

PMID:11752121 PMID:12364868

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]

PMID:11752121 PMID:12364868

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 18

multiple interactions

ISO

Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]

PMID:11752121 PMID:12364868 PMID:16723495

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO
EXP

[Famotidine co-treated with Sucralfate] results in decreased expression of IL1B mRNA
Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]

PMID:17717918 PMID:27474069 PMID:27645307

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 4

multiple interactions

ISO

Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

EXP

Famotidine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of IL6 protein]

PMID:17603938 PMID:27474069

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

matrix metallopeptidase 1

multiple interactions

ISO

Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 9

multiple interactions

EXP

Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]

PMID:17603938 PMID:22257724

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions
increases expression

ISO
EXP

Famotidine inhibits the reaction [Acids results in increased activity of MPO protein]
Famotidine results in increased expression of MPO protein
Famotidine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]

PMID:12023551 PMID:16091555 PMID:16437673 PMID:17603938 PMID:18726076 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

Famotidine inhibits the reaction [Indomethacin results in increased expression of MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

Famotidine inhibits the reaction [Indomethacin results in increased expression of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

multiple interactions

ISO

Famotidine inhibits the reaction [Indomethacin results in increased expression of NFKB2 mRNA]

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

natriuretic peptide B

decreases expression

EXP

Famotidine results in decreased expression of NPPB protein

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

neurotrophin 3

multiple interactions

EXP

[Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

proliferating cell nuclear antigen

multiple interactions

EXP

[Famotidine co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Famotidine promotes the reaction [Acetic Acid results in increased expression of PCNA protein]

PMID:18853145 PMID:19251492

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

EXP

Famotidine results in decreased expression of PPP3CA protein

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

peroxiredoxin 3

increases expression

EXP

Famotidine results in increased expression of PRDX3 protein

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

prolactin

increases expression

ISO

Famotidine results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prostaglandin-endoperoxide synthase 1

multiple interactions

EXP

Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP
ISO

Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]
Famotidine inhibits the reaction [Indomethacin results in decreased expression of PTGS2 mRNA]

PMID:27645307 PMID:38447874

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Famotidine inhibits the reaction [Ethanol results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RT1 class Ia, locus A2

affects expression

ISO

Famotidine affects the expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class II, locus DMb

affects expression

ISO

Famotidine affects the expression of HLA-DMB mRNA

NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246

G

serpin family E member 1

multiple interactions

EXP

Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier family 19 member 3

multiple interactions
increases uptake

ISO

Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
SLC19A3 protein results in increased uptake of Famotidine

NCBI chr 9:91,723,799...91,747,499
Ensembl chr 9:91,724,718...91,754,991

G

solute carrier family 22 member 1

multiple interactions
increases uptake
affects transport

ISO
EXP

Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Famotidine
SLC22A1 protein affects the transport of Famotidine

PMID:16006492 PMID:16141367

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

increases uptake
multiple interactions

ISO
EXP

SLC22A2 protein results in increased uptake of Famotidine
Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:15496291 PMID:16006492 PMID:16141367 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions
decreases activity

ISO

Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Famotidine results in decreased activity of SLC22A3 protein

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 8

multiple interactions
increases uptake

ISO
EXP

estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]

PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 47 member 1

multiple interactions

ISO

Famotidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

tachykinin receptor 1

multiple interactions

ISO

Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492

G

toll-like receptor 4

multiple interactions

ISO

Famotidine inhibits the reaction [Indomethacin results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions
increases secretion

ISO
EXP

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Famotidine results in increased secretion of TNF protein
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]
Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]

PMID:11752121 PMID:12538815 PMID:17603938 PMID:17698507 PMID:19277450 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Hydroxyzine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

angiotensin converting enzyme 2

increases activity
decreases expression

ISO

Hydroxyzine results in increased activity of ACE2 protein
Hydroxyzine results in decreased expression of ACE2 mRNA

PMID:21859683 PMID:32808185

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

glutathione S-transferase pi 1

multiple interactions

ISO

Hydroxyzine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

hexosaminidase subunit beta

affects secretion

EXP

Hydroxyzine affects the secretion of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

histamine receptor H 1

multiple interactions

ISO

Hydroxyzine binds to and results in decreased activity of HRH1 protein

PMID:2864258 PMID:19057127

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 1 beta

decreases expression

ISO

Hydroxyzine results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Hydroxyzine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 4

decreases expression

ISO

Hydroxyzine results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Hydroxyzine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Hydroxyzine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

solute carrier family 22 member 2

multiple interactions

ISO

Hydroxyzine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Hydroxyzine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

multiple interactions

ISO

Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

Fc epsilon receptor Ig

decreases expression

EXP

Ketotifen results in decreased expression of FCER1G protein

NCBI chr13:86,181,908...86,186,766
Ensembl chr13:86,181,908...86,186,859

G

intercellular adhesion molecule 1

multiple interactions

ISO

[Ketotifen co-treated with nimesulide] results in decreased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

[Ketotifen co-treated with nimesulide] results in decreased expression of IL1B protein
Ketotifen results in increased expression of IL1B protein

PMID:12121561 PMID:15265675

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP

Ketotifen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

nerve growth factor

multiple interactions

EXP

Ketotifen inhibits the reaction [Capsaicin results in increased expression of NGF protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

PPARG coactivator 1 alpha

increases expression

ISO

Ketotifen results in increased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

selectin E

multiple interactions

ISO

[Ketotifen co-treated with nimesulide] results in decreased expression of SELE protein

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

solute carrier family 22 member 2

multiple interactions

ISO

Ketotifen inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

sterol regulatory element binding transcription factor 1

increases expression

ISO

Ketotifen results in increased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

tumor necrosis factor

multiple interactions

ISO
EXP

[Ketotifen co-treated with nimesulide] results in decreased expression of TNF protein
Ketotifen inhibits the reaction [Capsaicin results in increased expression of TNF protein]

PMID:12121561 PMID:15265675

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vascular cell adhesion molecule 1

multiple interactions

ISO

[Ketotifen co-treated with nimesulide] results in decreased expression of VCAM1 protein

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

ISO

Loratadine results in decreased activity of ABCB11 protein
Loratadine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:23956101 PMID:24014644 PMID:28437613

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

affects response to substance
increases export

ISO

ABCB1A protein affects the susceptibility to Loratadine
ABCB1 protein results in increased export of Loratadine

PMID:12584158 PMID:15502009

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

affects response to substance

ISO

ABCB1B protein affects the susceptibility to Loratadine

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Loratadine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 1

decreases response to substance

ISO

ABCC1 protein results in decreased susceptibility to Loratadine

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

angiotensin converting enzyme 2

affects binding

ISO

Loratadine binds to ACE2 protein

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

arachidonate 5-lipoxygenase

decreases activity

ISO

Loratadine analog results in decreased activity of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

ISO

Loratadine results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

androgen receptor

increases expression

ISO

Loratadine results in increased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Loratadine results in increased expression of ASNS mRNA

PMID:15342952 PMID:17567588

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

caspase 3

increases cleavage
increases activity
multiple interactions

ISO

Loratadine results in increased cleavage of CASP3 protein
Loratadine results in increased activity of CASP3 protein
Dasatinib promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein]

PMID:20570632 PMID:22700542

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity
multiple interactions

ISO

Loratadine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases cleavage

ISO

Loratadine results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

Loratadine results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

ISO

Loratadine results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing

ISO

CYP2D6 gene polymorphism affects the metabolism of Loratadine; CYP2D6 protein affects the metabolism of Loratadine

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

Loratadine analog results in decreased activity of CYP3A4 protein; Loratadine results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

estrogen receptor 1

increases expression

ISO

Loratadine results in increased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

fatty acid binding protein 1

increases expression

ISO

Loratadine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17567588

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

ISO

Loratadine results in increased expression of GDPD3 mRNA

NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606

G

hepsin

increases expression

ISO

Loratadine results in increased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199

G

histamine receptor H 1

affects binding

ISO

Loratadine analog binds to HRH1 protein; Loratadine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

inhibin subunit beta E

increases expression

ISO

Loratadine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17567588

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions
affects activity

ISO

Loratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Loratadine binds to and results in decreased activity of KCNH2 protein; Loratadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Loratadine affects the activity of KCNH2 protein

PMID:9658196 PMID:10604956 PMID:11705456 PMID:16278312 PMID:21158687 More...

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

lanosterol synthase

increases expression

ISO

Loratadine results in increased expression of LSS mRNA

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ISO

Loratadine results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Loratadine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17567588

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

ribosomal protein S6

decreases expression

ISO

Loratadine results in decreased expression of RPS6 protein modified form

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

serpin family A member 3N

increases expression

ISO

Loratadine results in increased expression of SERPINA3 mRNA

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

solute carrier family 2 member 3

decreases expression

ISO

Loratadine results in decreased expression of SLC2A3 mRNA

PMID:15342952 PMID:17567588

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Loratadine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

transgelin

decreases expression

ISO

Loratadine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17567588

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amphiregulin

multiple interactions
decreases expression

ISO

[YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

regenerating family member 1 alpha

decreases expression
multiple interactions

ISO

loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA

NCBI chr 4:112,450,466...112,453,130
Ensembl chr 4:112,450,468...112,453,585

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

ISO

Pyrilamine results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

coagulation factor III, tissue factor

multiple interactions

ISO

Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

histamine receptor H 1

multiple interactions
decreases activity
affects binding

ISO
EXP

Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Pyrilamine results in decreased susceptibility to CXCL8 protein]; Lipopolysaccharides promotes the reaction [Pyrilamine binds to HRH1 protein]; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]
Pyrilamine results in decreased activity of HRH1 protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Pyrilamine binds to HRH1 protein]; [Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit; Pyrilamine binds to and results in decreased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]

PMID:1912125 PMID:2419744 PMID:2606156 PMID:3379823 PMID:7522859 More...

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
affects activity

ISO

Pyrilamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pyrilamine affects the activity of KCNH2 protein

PMID:16278312 PMID:21158687

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

kininogen 1

decreases activity

ISO

Pyrilamine results in decreased activity of KNG1 protein

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

mitogen activated protein kinase 1

multiple interactions

ISO

Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

nerve growth factor

multiple interactions

EXP

Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

neurotrophin 3

multiple interactions

EXP

[Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

solute carrier family 22 member 2

multiple interactions

ISO

Pyrilamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

ISO

carebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; ebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine; SLC22A5 protein affects the transport of and affects the abundance of Pyrilamine

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 6 member 3

multiple interactions

ISO

Pyrilamine analog binds to and affects the activity of SLC6A3 protein

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

affects binding

ISO

Pyrilamine analog binds to SLC6A4 protein

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

EXP

Methapyrilene results in decreased expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

aminoadipate aminotransferase

decreases expression

EXP

Methapyrilene results in decreased expression of AADAT mRNA

NCBI chr16:34,520,236...34,566,388
Ensembl chr16:34,520,238...34,566,540

G

aminoadipate-semialdehyde synthase

decreases expression

EXP

Methapyrilene results in decreased expression of AASS mRNA

NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:52,572,147...52,657,600

G

4-aminobutyrate aminotransferase

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of ABAT mRNA
Methapyrilene results in increased methylation of ABAT intron

PMID:16393664 PMID:23274394 PMID:30157460

NCBI chr10:7,503,351...7,599,474
Ensembl chr10:7,492,022...7,599,474

G

ATP binding cassette subfamily A member 1

decreases expression

EXP

Methapyrilene results in decreased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily A member 3

increases methylation

ISO

Methapyrilene results in increased methylation of ABCA3 intron

NCBI chr10:13,886,948...13,944,286
Ensembl chr10:13,887,083...13,944,285

G

ATP binding cassette subfamily B member 11

decreases expression

ISO

Methapyrilene results in decreased expression of ABCB11 mRNA

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of ABCB1A mRNA
Methapyrilene results in decreased expression of ABCB1A mRNA

PMID:28935588 PMID:30467583

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

increases expression

EXP

Methapyrilene results in increased expression of ABCB1B mRNA

PMID:15120968 PMID:23274394

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

increases expression
decreases methylation
decreases expression

EXP
ISO

Methapyrilene results in increased expression of ABCB4 mRNA
Methapyrilene results in decreased methylation of ABCB4 intron
Methapyrilene results in decreased expression of ABCB4 mRNA

PMID:15120968 PMID:28935588 PMID:30157460

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 1

affects methylation

ISO

Methapyrilene affects the methylation of ABCC1 intron

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 12

increases methylation

ISO

Methapyrilene results in increased methylation of ABCC12 intron

NCBI chr19:36,722,550...36,798,868
Ensembl chr19:36,722,575...36,793,993

G

ATP binding cassette subfamily C member 2

increases expression

EXP

Methapyrilene results in increased expression of ABCC2 mRNA

PMID:22484513 PMID:28529062

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression
increases methylation
decreases expression

EXP
ISO

Methapyrilene results in increased expression of ABCC3 mRNA
Methapyrilene results in increased methylation of ABCC3 intron
Methapyrilene results in decreased expression of ABCC3 mRNA

PMID:28935588 PMID:30157460

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of ABCC4 mRNA
Methapyrilene results in increased methylation of ABCC4 intron

PMID:28529062 PMID:30157460

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

increases methylation

ISO

Methapyrilene results in increased methylation of ABCC5 intron

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

ATP binding cassette subfamily C member 8

increases methylation

ISO

Methapyrilene results in increased methylation of ABCC8 intron

NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982

G

ATP binding cassette subfamily D member 3

decreases expression

EXP

Methapyrilene results in decreased expression of ABCD3 mRNA

NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504

G

ATP binding cassette subfamily E member 1

decreases expression

EXP

Methapyrilene results in decreased expression of ABCE1 mRNA

NCBI chr19:45,109,880...45,134,819
Ensembl chr19:45,109,906...45,134,819

G

ATP binding cassette subfamily G member 1

increases methylation

ISO

Methapyrilene results in increased methylation of ABCG1 intron

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

abhydrolase domain containing 10, depalmitoylase

increases expression

EXP

Methapyrilene results in increased expression of ABHD10 mRNA

NCBI chr11:68,543,860...68,556,059
Ensembl chr11:68,543,606...68,557,640

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

increases expression

EXP

Methapyrilene results in increased expression of ABHD5 mRNA

NCBI chr 8:130,877,834...130,903,947
Ensembl chr 8:130,877,703...130,903,947

G

abhydrolase domain containing 6, acylglycerol lipase

decreases expression

EXP

Methapyrilene results in decreased expression of ABHD6 mRNA

NCBI chr15:19,289,967...19,337,500
Ensembl chr15:19,289,969...19,337,193

G

abl-interactor 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ABI1 intron

NCBI chr17:90,006,917...90,088,002
Ensembl chr17:90,006,925...90,087,827

G

ABL proto-oncogene 2, non-receptor tyrosine kinase

increases methylation

ISO

Methapyrilene results in increased methylation of ABL2 intron

NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775

G

actin binding LIM protein family, member 2

affects methylation
increases methylation

ISO

Methapyrilene affects the methylation of ABLIM2 exon
Methapyrilene results in increased methylation of ABLIM2 intron

NCBI chr14:79,090,046...79,214,986
Ensembl chr14:79,090,923...79,214,972

G

actin binding LIM protein family, member 3

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of ABLIM3 intron
Methapyrilene results in decreased expression of ABLIM3 mRNA

PMID:30157460 PMID:30467583

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:57,527,917...57,646,710

G

ABR activator of RhoGEF and GTPase

affects methylation

ISO

Methapyrilene affects the methylation of ABR intron

NCBI chr10:61,760,743...61,959,526
Ensembl chr10:61,760,743...61,959,467

G

ankyrin repeat and BTB domain containing 3

increases methylation

ISO

Methapyrilene results in increased methylation of ABTB3 intron

NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110

G

acetyl-CoA acyltransferase 1A

decreases expression

EXP

Methapyrilene results in decreased expression of ACAA1 mRNA

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241

G

acetyl-CoA carboxylase alpha

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of ACACA intron
Methapyrilene results in decreased expression of ACACA mRNA

PMID:30157460 PMID:30467583

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase family, member 11

decreases expression

EXP

Methapyrilene results in decreased expression of ACAD11 mRNA

NCBI chr 8:113,560,142...113,625,346
Ensembl chr 8:113,560,196...113,625,352

G

acyl-CoA dehydrogenase family, member 9

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of ACAD9 exon
Methapyrilene results in decreased expression of ACAD9 mRNA

PMID:30157460 PMID:30467583

NCBI chr 2:120,871,329...120,894,306
Ensembl chr 2:120,871,227...120,894,709

G

acyl-CoA dehydrogenase, long chain

decreases expression

EXP

Methapyrilene results in decreased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

acyl-CoA dehydrogenase short chain

decreases expression

EXP

Methapyrilene results in decreased expression of ACADS mRNA

NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103

G

acyl-CoA dehydrogenase, short/branched chain

decreases expression

EXP

Methapyrilene results in decreased expression of ACADSB mRNA

NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561

G

acyl-CoA dehydrogenase, very long chain

decreases expression

EXP

Methapyrilene results in decreased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

acetyl-CoA acetyltransferase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acetyl-CoA acetyltransferase 2

increases expression

EXP

Methapyrilene results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

acyl-CoA binding domain containing 5

decreases expression

EXP

Methapyrilene results in decreased expression of ACBD5 mRNA

NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286

G

alkaline ceramidase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACER1 intron

NCBI chr 9:1,881,361...1,911,439
Ensembl chr 9:1,881,361...1,919,416

G

ATP citrate lyase

increases methylation

ISO

Methapyrilene results in increased methylation of ACLY exon

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

aconitase 1

increases expression
decreases expression

EXP
ISO

Methapyrilene results in increased expression of ACO1 mRNA
Methapyrilene results in decreased expression of ACO1 mRNA

PMID:15890375 PMID:28935588 PMID:30467583

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

decreases expression

EXP

Methapyrilene results in decreased expression of ACO2 protein

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACOT1 polyA tail

NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749

G

acyl-CoA thioesterase 11

affects methylation

ISO

Methapyrilene affects the methylation of ACOT11 intron

NCBI chr 5:126,756,255...126,804,526
Ensembl chr 5:126,756,255...126,804,507

G

acyl-CoA thioesterase 12

decreases expression

EXP

Methapyrilene results in decreased expression of ACOT12 mRNA

NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:24,721,910...24,765,298

G

acyl-CoA thioesterase 2

decreases expression

EXP

Methapyrilene results in decreased expression of ACOT2 mRNA

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

acyl-CoA oxidase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACOX1 intron

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA oxidase 2

decreases expression

EXP

Methapyrilene results in decreased expression of ACOX2 mRNA

PMID:28529062 PMID:30467583

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392

G

acyl-CoA oxidase 3, pristanoyl

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACOX3 intron

NCBI chr14:79,358,604...79,405,160
Ensembl chr14:79,302,042...79,400,881

G

acyl-CoA synthetase bubblegum family member 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACSBG2 intron

NCBI chr 9:1,770,971...1,802,635
Ensembl chr 9:1,770,972...1,801,655

G

acyl-CoA synthetase long-chain family member 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ACSL4 intron

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:110,739,648...110,803,261

G

acyl-CoA synthetase medium-chain family member 5

decreases expression

EXP

Methapyrilene results in decreased expression of ACSM5 mRNA

NCBI chr 1:183,302,241...183,328,175
Ensembl chr 1:183,294,105...183,329,925

G

actin, beta

decreases expression

EXP

Methapyrilene results in decreased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin-like 6B

increases methylation

ISO

Methapyrilene results in increased methylation of ACTL6B intron

NCBI chr12:24,761,660...24,778,193
Ensembl chr12:24,761,693...24,778,151

G

actinin alpha 2

increases methylation

ISO

Methapyrilene results in increased methylation of ACTN2 intron

NCBI chr17:62,835,055...62,902,331
Ensembl chr17:62,812,988...62,903,552

G

actin related protein 10

increases methylation

ISO

Methapyrilene results in increased methylation of ACTR10 intron

NCBI chr 6:95,182,082...95,208,325
Ensembl chr 6:95,182,111...95,209,021

G

aminoacylase 3

decreases expression

EXP

Methapyrilene results in decreased expression of ACY3 mRNA

NCBI chr 1:210,709,238...210,715,258
Ensembl chr 1:210,709,294...210,715,633

G

ADAM metallopeptidase domain 10

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADAM10 intron

NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600

G

ADAM metallopeptidase domain 11

increases methylation

ISO

Methapyrilene results in increased methylation of ADAM11 intron

NCBI chr10:88,224,185...88,242,865
Ensembl chr10:88,224,347...88,242,864

G

ADAM metallopeptidase domain 22

increases methylation

ISO

Methapyrilene results in increased methylation of ADAM22 intron

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:26,671,112...26,925,843

G

ADAM metallopeptidase domain 23

increases methylation

ISO

Methapyrilene results in increased methylation of ADAM23 intron

NCBI chr 9:72,356,479...72,503,545
Ensembl chr 9:72,356,479...72,503,545

G

ADAM metallopeptidase domain 28

increases methylation

ISO

Methapyrilene results in increased methylation of ADAM28 intron

NCBI chr15:50,184,286...50,250,605
Ensembl chr15:50,127,516...50,250,526

G

ADAM metallopeptidase with thrombospondin type 1 motif, 10

increases methylation

ISO

Methapyrilene results in increased methylation of ADAMTS10 intron

NCBI chr 7:15,033,859...15,063,800
Ensembl chr 7:15,033,934...15,063,800

G

ADAM metallopeptidase with thrombospondin type 1 motif, 13

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADAMTS13 intron

NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:30,697,942...30,736,540

G

ADAM metallopeptidase with thrombospondin type 1 motif, 14

increases methylation

ISO

Methapyrilene results in increased methylation of ADAMTS14 exon; Methapyrilene results in increased methylation of ADAMTS14 intron

NCBI chr20:29,685,876...29,762,685
Ensembl chr20:29,685,876...29,762,682

G

ADAM metallopeptidase with thrombospondin type 1 motif, 17

increases methylation

ISO

Methapyrilene results in increased methylation of ADAMTS17 intron

NCBI chr 1:129,856,062...130,178,430
Ensembl chr 1:129,856,074...130,176,844

G

ADAM metallopeptidase with thrombospondin type 1 motif, 18

increases methylation

ISO

Methapyrilene results in increased methylation of ADAMTS18 intron

NCBI chr19:58,596,095...58,749,239
Ensembl chr19:58,597,761...58,749,138

G

ADAM metallopeptidase with thrombospondin type 1 motif, 19

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADAMTS19 intron

NCBI chr18:54,545,357...54,729,184
Ensembl chr18:54,545,357...54,729,181

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

affects methylation

ISO

Methapyrilene affects the methylation of ADAMTS2 intron

NCBI chr10:35,422,030...35,627,483
Ensembl chr10:35,422,030...35,627,483

G

ADAM metallopeptidase with thrombospondin type 1 motif, 20

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADAMTS20 intron

NCBI chr 7:127,275,538...127,407,325
Ensembl chr 7:127,275,538...127,407,296

G

ADAMTS-like 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADAMTSL1 intron

NCBI chr 5:105,010,471...105,965,792
Ensembl chr 5:105,010,464...105,964,394

G

ADAMTS-like 3

increases methylation

ISO

Methapyrilene results in increased methylation of ADAMTSL3 intron

NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:145,698,004...146,006,195

G

ArfGAP with dual PH domains 1

increases methylation

ISO

Methapyrilene results in increased methylation of ADAP1 intron

NCBI chr12:20,438,091...20,489,961
Ensembl chr12:20,438,063...20,495,020

G

adenosine deaminase, RNA-specific, B1

increases methylation

ISO

Methapyrilene results in increased methylation of ADARB1 intron

NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,164...11,350,415

G

adenosine deaminase RNA specific B2

affects methylation

ISO

Methapyrilene affects the methylation of ADARB2 intron

NCBI chr17:66,660,586...67,211,104
Ensembl chr17:66,665,506...67,210,749

G

adenylate cyclase 1

decreases methylation
increases methylation

ISO

Methapyrilene results in decreased methylation of ADCY1 3' UTR
Methapyrilene results in increased methylation of ADCY1 intron

NCBI chr14:86,125,119...86,234,459
Ensembl chr14:86,124,850...86,261,075

G

adenylate cyclase 10

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of ADCY10 mRNA
Methapyrilene results in increased methylation of ADCY10 gene

PMID:30467583 PMID:31555880

NCBI chr13:80,280,595...80,366,939
Ensembl chr13:80,284,295...80,366,926

G

adenylate cyclase 2

affects methylation

ISO

Methapyrilene affects the methylation of ADCY2 intron

NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645

G

adenylate cyclase 3

increases methylation

ISO

Methapyrilene results in increased methylation of ADCY3 intron

NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:32,843,961...32,923,173

G

adenylate cyclase 5

increases methylation

ISO

Methapyrilene results in increased methylation of ADCY5 intron

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

adenylate cyclase 7

increases methylation

ISO

Methapyrilene results in increased methylation of ADCY7 intron

NCBI chr19:34,913,154...34,972,366
Ensembl chr19:34,914,322...34,936,743

G

ADCYAP receptor type I

increases methylation

ISO

Methapyrilene results in increased methylation of ADCYAP1R1 intron

NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:85,924,100...85,972,973

G

adhesion G protein-coupled receptor A2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ADGRA2 intron

NCBI chr16:71,635,814...71,674,275
Ensembl chr16:71,636,164...71,674,154

G

adhesion G protein-coupled receptor B1

increases methylation

ISO

Methapyrilene results in increased methylation of ADGRB1 intron

NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:108,293,818...108,365,870

G

adhesion G protein-coupled receptor B2

increases methylation

ISO

Methapyrilene results in increased methylation of ADGRB2 intron

NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:147,611,580...147,646,726

G

adhesion G protein-coupled receptor D1

increases methylation

ISO

Methapyrilene results in increased methylation of ADGRD1 intron

NCBI chr12:33,124,981...33,239,778
Ensembl chr12:33,125,915...33,272,509

G

adhesion G protein-coupled receptor G2

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of ADGRG2 intron
Methapyrilene results in decreased expression of ADGRG2 mRNA

PMID:30157460 PMID:30467583

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:38,106,067...38,231,331

G

adhesion G protein-coupled receptor L2

decreases expression

EXP

Methapyrilene results in decreased expression of ADGRL2 mRNA

NCBI chr 2:240,356,176...240,987,246
Ensembl chr 2:240,356,177...240,855,933

G

adhesion G protein-coupled receptor V1

increases methylation
affects methylation

ISO

Methapyrilene results in increased methylation of ADGRV1 exon
Methapyrilene affects the methylation of ADGRV1 intron

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:13,067,150...13,647,372

G

alcohol dehydrogenase, iron containing, 1

decreases expression

EXP

Methapyrilene results in decreased expression of ADHFE1 mRNA

NCBI chr 5:14,488,784...14,515,405
Ensembl chr 5:14,488,788...14,515,835

G

adrenomedullin

increases expression

EXP

Methapyrilene results in increased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

ADP-dependent glucokinase

decreases expression

EXP

Methapyrilene results in decreased expression of ADPGK mRNA

NCBI chr 8:68,595,194...68,623,179
Ensembl chr 8:68,595,248...68,623,178

G

adrenoceptor alpha 1A

increases methylation

ISO

Methapyrilene results in increased methylation of ADRA1A intron

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

AE binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of AEBP2 intron

NCBI chr 4:175,258,286...175,297,149
Ensembl chr 4:175,258,887...175,326,422

G

actin filament associated protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AFAP1 3' UTR

NCBI chr14:78,967,961...79,081,032
Ensembl chr14:78,967,961...79,080,939

G

actin filament associated protein 1-like 2

increases methylation

ISO

Methapyrilene results in increased methylation of AFAP1L2 intron

NCBI chr 1:265,969,368...266,065,951
Ensembl chr 1:265,969,368...266,065,943

G

ALF transcription elongation factor 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of AFF2 intron

NCBI chr X:152,972,579...153,477,080
Ensembl chr X:152,972,581...153,477,080

G

ALF transcription elongation factor 3

increases methylation

ISO

Methapyrilene results in increased methylation of AFF3 intron

NCBI chr 9:47,894,903...48,352,380
Ensembl chr 9:47,894,903...48,353,000

G

ALF transcription elongation factor 4

decreases expression

EXP

Methapyrilene results in decreased expression of AFF4 mRNA

NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,999,579...38,080,580

G

arylformamidase

decreases expression

EXP

Methapyrilene results in decreased expression of AFMID mRNA

NCBI chr10:103,544,822...103,560,408
Ensembl chr10:103,544,841...103,560,408

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AGAP1 intron

NCBI chr 9:97,487,382...97,922,870
Ensembl chr 9:97,487,406...97,922,870

G

AGBL carboxypeptidase 4

increases methylation

ISO

Methapyrilene results in increased methylation of AGBL4 intron

NCBI chr 5:130,483,551...131,762,906

G

ArfGAP with FG repeats 2

affects methylation

ISO

Methapyrilene affects the methylation of AGFG2 intron

NCBI chr12:24,649,008...24,692,069
Ensembl chr12:24,649,038...24,685,197

G

acylglycerol kinase

increases methylation

ISO

Methapyrilene results in increased methylation of AGK intron

NCBI chr 4:70,081,550...70,160,642
Ensembl chr 4:70,081,035...70,160,709

G

argonaute RISC catalytic component 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of AGO2 intron

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

1-acylglycerol-3-phosphate O-acyltransferase 3

decreases expression

EXP

Methapyrilene results in decreased expression of AGPAT3 mRNA

NCBI chr20:10,330,650...10,415,026
Ensembl chr20:10,394,465...10,410,632

G

adenosylhomocysteinase

increases expression

EXP

Methapyrilene results in increased expression of AHCY protein

NCBI chr 3:164,029,338...164,044,562
Ensembl chr 3:164,029,338...164,044,587

G

adenosylhomocysteinase-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of AHCYL1 mRNA

NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:197,982,344...198,033,930

G

AT hook, DNA binding motif, containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of AHDC1 intron

NCBI chr 5:150,512,182...150,578,804
Ensembl chr 5:150,512,037...150,583,144

G

Abelson helper integration site 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AHI1 intron

NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:17,582,006...17,711,774

G

AHNAK nucleoprotein

affects methylation

ISO

Methapyrilene affects the methylation of AHNAK intron

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

apoptosis inducing factor, mitochondria associated 1

decreases expression

EXP

Methapyrilene results in decreased expression of AIFM1 mRNA

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

androgen-induced 1

decreases expression

EXP

Methapyrilene results in decreased expression of AIG1 mRNA

NCBI chr 1:9,866,546...10,089,454
Ensembl chr 1:9,866,548...10,089,155

G

aryl hydrocarbon receptor-interacting protein-like 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AIPL1 intron

NCBI chr10:57,154,226...57,163,455
Ensembl chr10:57,154,226...57,163,455

G

autoimmune regulator

decreases methylation

ISO

Methapyrilene results in decreased methylation of AIRE exon

NCBI chr20:10,635,775...10,650,709
Ensembl chr20:10,635,775...10,650,709

G

adenylate kinase 3

decreases expression

EXP

Methapyrilene results in decreased expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

A-kinase anchoring protein 14

increases methylation

ISO

Methapyrilene results in increased methylation of AKAP14 intron

NCBI chr X:121,261,195...121,276,376
Ensembl chr X:121,259,899...121,276,376

G

A-kinase anchoring protein 9

decreases expression

EXP

Methapyrilene results in decreased expression of AKAP9 mRNA

NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:31,011,475...31,147,338

G

A-kinase interacting protein 1

increases expression

EXP

Methapyrilene results in increased expression of AKIP1 mRNA

NCBI chr 1:173,169,520...173,178,445
Ensembl chr 1:173,169,458...173,178,445

G

AT-hook transcription factor

affects methylation

ISO

Methapyrilene affects the methylation of AKNA exon; Methapyrilene affects the methylation of AKNA intron

NCBI chr 5:81,792,928...81,839,936
Ensembl chr 5:81,792,929...81,831,528

G

aldo-keto reductase family 1 member B1

increases expression

EXP

Methapyrilene results in increased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B15

increases expression

EXP

Methapyrilene results in increased expression of AKR1B8 mRNA

NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349

G

aldo-keto reductase family 1, member C14

decreases expression

EXP

Methapyrilene results in decreased expression of AKR1C14 mRNA

NCBI chr17:71,066,197...71,083,184
Ensembl chr17:71,066,200...71,083,157

G

aldo-keto reductase family 1, member C3

increases methylation

ISO

Methapyrilene results in increased methylation of AKR1C3 intron

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

aldo-keto reductase family 1, member D1

decreases expression
increases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of AKR1D1 mRNA
Methapyrilene results in increased expression of AKR1D1 protein
Methapyrilene results in decreased methylation of AKR1D1 intron

PMID:30157460 PMID:30467583

NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540

G

aldo-keto reductase family 7 member A3

increases expression

EXP

Methapyrilene results in increased expression of AKR7A3 mRNA

PMID:15120968 PMID:21813463 PMID:22484513

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

AKT serine/threonine kinase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AKT1 intron

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

5'-aminolevulinate synthase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

albumin

decreases expression

ISO

Methapyrilene results in decreased expression of ALB mRNA

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of ALDH1A1 mRNA
Methapyrilene results in decreased expression of ALDH1A1 mRNA

PMID:21813463 PMID:22484513 PMID:30467583

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases methylation

ISO

Methapyrilene results in increased methylation of ALDH1A3 exon

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase 1 family, member L1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALDH1L1 intron

NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:124,617,217...124,664,704

G

aldehyde dehydrogenase 1 family, member L2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALDH1L2 intron

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398

G

aldehyde dehydrogenase 2 family member

increases expression

EXP

Methapyrilene results in increased expression of ALDH2 protein

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 3 family, member A2

decreases expression

EXP

Methapyrilene results in decreased expression of ALDH3A2 mRNA

NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648

G

aldehyde dehydrogenase 3 family, member B2

increases methylation

ISO

Methapyrilene results in increased methylation of ALDH3B2 intron

NCBI chr 1:210,679,749...210,694,187
Ensembl chr 1:210,675,302...210,694,155

G

aldehyde dehydrogenase 3 family, member B3

increases methylation

ISO

Methapyrilene results in increased methylation of ALDH3B2 intron

NCBI chr 1:210,617,090...210,629,886
Ensembl chr 1:210,622,639...210,629,879

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

EXP

Methapyrilene results in decreased expression of ALDH4A1 mRNA

NCBI chr 5:157,163,189...157,188,673
Ensembl chr 5:157,162,945...157,188,673

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

EXP

Methapyrilene results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

aldehyde dehydrogenase 9 family, member A1

decreases expression

EXP

Methapyrilene results in decreased expression of ALDH9A1 mRNA

NCBI chr13:82,038,679...82,055,478
Ensembl chr13:82,038,533...82,055,481

G

aldolase, fructose-bisphosphate A

increases expression

EXP

Methapyrilene results in increased expression of ALDOA mRNA

PMID:16393664 PMID:28935588

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

aldolase, fructose-bisphosphate B

decreases expression

EXP

Methapyrilene results in decreased expression of ALDOB mRNA

NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:68,684,542...68,716,740

G

ALG11, alpha-1,2-mannosyltransferase

decreases expression

EXP

Methapyrilene results in decreased expression of ALG11 mRNA

NCBI chr16:76,642,979...76,654,052
Ensembl chr16:76,646,795...76,654,040

G

ALG13, UDP-N-acetylglucosaminyltransferase subunit

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALG13 intron

NCBI chr X:112,703,015...112,764,924
Ensembl chr X:112,702,796...112,739,356

G

ALG14, UDP-N-acetylglucosaminyltransferase subunit

decreases expression

EXP

Methapyrilene results in decreased expression of ALG14 mRNA

NCBI chr 2:212,053,008...212,130,136
Ensembl chr 2:212,044,969...212,130,140

G

ALK receptor tyrosine kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALK intron

NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:28,632,197...29,349,721

G

arachidonate epidermal lipoxygenase 3

increases methylation

ISO

Methapyrilene results in increased methylation of ALOXE3 intron

NCBI chr10:54,329,224...54,353,167
Ensembl chr10:54,329,043...54,353,166

G

alkaline phosphatase, biomineralization associated

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALPL intron

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

ALS2 C-terminal like

decreases expression

EXP

Methapyrilene results in decreased expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843

G

ALX homeobox 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ALX4 intron

NCBI chr 3:100,067,052...100,103,624
Ensembl chr 3:100,067,052...100,103,624

G

Aly/REF export factor

increases expression

EXP

Methapyrilene results in increased expression of ALYREF mRNA

NCBI chr10:106,369,750...106,373,395
Ensembl chr10:106,369,750...106,373,395

G

alpha-methylacyl-CoA racemase

decreases expression

EXP

Methapyrilene results in decreased expression of AMACR mRNA

PMID:15120968 PMID:28529062

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379

G

amidohydrolase domain containing 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of AMDHD2 intron

NCBI chr10:13,692,136...13,700,632
Ensembl chr10:13,692,146...13,700,632

G

APC membrane recruitment protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of AMER1 exon

NCBI chr X:64,310,492...64,326,377
Ensembl chr X:64,300,953...64,326,332

G

APC membrane recruitment protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of AMER3 exon

NCBI chr 9:44,286,274...44,298,246
Ensembl chr 9:44,268,722...44,351,398

G

angiomotin like 2

increases methylation

ISO

Methapyrilene results in increased methylation of AMOTL2 intron

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030

G

adenosine monophosphate deaminase 3

increases expression

EXP

Methapyrilene results in increased expression of AMPD3 mRNA

NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:174,294,867...174,364,608

G

archaelysin family metallopeptidase 2

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of AMZ2 mRNA
Methapyrilene results in increased methylation of AMZ2 intron

PMID:30157460 PMID:30467583

NCBI chr10:94,901,053...94,911,629
Ensembl chr10:94,901,129...94,911,627

G

anaphase promoting complex subunit 2

increases methylation

ISO

Methapyrilene results in increased methylation of ANAPC2 intron

NCBI chr 3:28,484,590...28,496,338
Ensembl chr 3:28,484,614...28,496,337

G

angiopoietin-like 3

increases expression

EXP

Methapyrilene results in increased expression of ANGPTL3 mRNA

NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444

G

ankyrin 1

affects methylation

ISO

Methapyrilene affects the methylation of ANK1 intron

NCBI chr16:75,578,824...75,757,464
Ensembl chr16:75,578,824...75,757,464

G

ankyrin 2

increases methylation

ISO

Methapyrilene results in increased methylation of ANK2 intron

NCBI chr 2:218,052,555...218,628,414
Ensembl chr 2:218,052,555...218,537,259

G

ankyrin-repeat and fibronectin type III domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANKFN1 intron

NCBI chr10:74,711,284...75,099,954

G

ankyrin repeat and FYVE domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of ANKFY1 intron

NCBI chr10:57,810,781...57,882,495
Ensembl chr10:57,810,781...57,882,495

G

ANKH inorganic pyrophosphate transport regulator

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of ANKH mRNA
Methapyrilene results in increased methylation of ANKH intron

PMID:30157460 PMID:30467583

NCBI chr 2:79,883,350...80,011,222
Ensembl chr 2:79,883,544...80,011,699

G

ankyrin repeat and KH domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANKHD1 intron

NCBI chr18:28,436,296...28,534,954
Ensembl chr18:28,436,394...28,534,954

G

ankyrin repeat and LEM domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of ANKLE2 intron

NCBI chr12:52,077,863...52,110,775
Ensembl chr12:52,077,480...52,108,708

G

ankyrin repeat domain 24

increases methylation

ISO

Methapyrilene results in increased methylation of ANKRD24 intron

NCBI chr 7:8,712,720...8,731,910
Ensembl chr 7:8,712,722...8,731,910

G

ankyrin repeat domain containing 26

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANKRD26 intron

NCBI chr 4:153,342,901...153,412,321
Ensembl chr 4:153,343,578...153,412,256

G

ankyrin repeat domain 31

increases methylation

ISO

Methapyrilene results in increased methylation of ANKRD31 intron

NCBI chr 2:29,793,882...29,987,621
Ensembl chr 2:29,813,940...29,977,149

G

ankyrin repeat domain 40

increases methylation

ISO

Methapyrilene results in increased methylation of ANKRD40 intron

NCBI chr10:79,778,966...79,792,212
Ensembl chr10:56,415,260...56,416,345
Ensembl chr10:56,415,260...56,416,345

G

ankyrin repeat domain 42

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of ANKRD42 mRNA
Methapyrilene results in increased methylation of ANKRD42 intron

PMID:30157460 PMID:30467583

NCBI chr 1:156,060,516...156,103,543
Ensembl chr 1:156,060,516...156,103,517

G

ankyrin repeat domain 44

decreases expression

EXP

Methapyrilene results in decreased expression of ANKRD44 mRNA

NCBI chr 9:63,621,193...63,921,999
Ensembl chr 9:63,555,869...63,921,940

G

ankyrin repeat and sterile alpha motif domain containing 4B

decreases expression

EXP

Methapyrilene results in decreased expression of ANKS4B mRNA

NCBI chr 1:183,934,528...183,989,127
Ensembl chr 1:183,978,769...183,989,122

G

ankyrin repeat and sterile alpha motif domain containing 6

increases methylation

ISO

Methapyrilene results in increased methylation of ANKS6 intron

NCBI chr 5:66,104,770...66,146,186
Ensembl chr 5:66,104,773...66,146,186

G

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANKZF1 intron

NCBI chr 9:84,136,862...84,143,830
Ensembl chr 9:84,136,862...84,145,091

G

anoctamin 1

affects methylation

ISO

Methapyrilene affects the methylation of ANO1 intron

NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550

G

anoctamin 2

increases methylation

ISO

Methapyrilene results in increased methylation of ANO2 intron

NCBI chr 4:160,200,471...160,541,830
Ensembl chr 4:160,182,152...160,541,821

G

anoctamin 3

increases methylation

ISO

Methapyrilene results in increased methylation of ANO3 intron

NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:117,692,103...118,004,675

G

anoctamin 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANO7 polyA tail

NCBI chr 9:101,364,915...101,392,711
Ensembl chr 9:101,364,842...101,394,173

G

acidic nuclear phosphoprotein 32 family member A

increases expression

EXP

Methapyrilene results in increased expression of ANP32A mRNA

NCBI chr 8:71,724,578...71,760,922
Ensembl chr 8:71,724,531...71,760,922

G

acidic nuclear phosphoprotein 32 family member E

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANP32E intron

NCBI chr 2:186,161,520...186,177,984
Ensembl chr 2:186,161,532...186,177,986

G

ANTXR cell adhesion molecule 1

increases expression

ISO

Methapyrilene results in increased expression of ANTXR1 mRNA

NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892

G

ANTXR cell adhesion molecule 2

increases methylation

ISO

Methapyrilene results in increased methylation of ANTXR2 intron

NCBI chr14:11,845,774...11,986,166
Ensembl chr14:11,845,700...11,986,168

G

annexin A2

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of ANXA2 mRNA
Methapyrilene results in increased methylation of ANXA2 intron

PMID:15120968 PMID:21813463 PMID:30157460

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

annexin A4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ANXA4 intron

NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:120,741,750...120,798,513

G

aminopeptidase O

decreases methylation
increases expression

ISO
EXP

Methapyrilene results in decreased methylation of AOPEP intron
Methapyrilene results in increased expression of AOPEP mRNA

PMID:30157460 PMID:30467583

NCBI chr17:1,817,001...2,133,008
Ensembl chr17:1,817,001...2,133,104

G

aldehyde oxidase 1

decreases expression

EXP

Methapyrilene results in decreased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

adaptor related protein complex 1 subunit gamma 1

decreases expression

EXP

Methapyrilene results in decreased expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

adaptor related protein complex 1 subunit mu 1

increases methylation

ISO

Methapyrilene results in increased methylation of AP1M1 intron

NCBI chr16:17,620,910...17,636,431
Ensembl chr16:17,616,187...17,636,462

G

adaptor related protein complex 1 subunit sigma 2

increases expression

EXP

Methapyrilene results in increased expression of AP1S2 mRNA

NCBI chr X:34,204,601...34,230,819
Ensembl chr X:34,204,603...34,228,529

G

adaptor related protein complex 2 subunit alpha 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of AP2A1 intron

NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:104,520,792...104,550,655

G

amyloid beta precursor protein binding family A member 1

increases methylation

ISO

Methapyrilene results in increased methylation of APBA1 intron

NCBI chr 1:230,790,297...230,995,986
Ensembl chr 1:230,790,297...230,995,986

G

amyloid beta precursor protein binding family B member 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of APBB2 intron

NCBI chr14:41,849,638...42,232,930
Ensembl chr14:41,911,785...42,232,280

G

APC regulator of WNT signaling pathway

increases methylation

ISO

Methapyrilene results in increased methylation of APC intron

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

APC down-regulated 1 like

increases methylation

ISO

Methapyrilene results in increased methylation of APCDD1L intron

NCBI chr 3:183,000,504...183,076,628
Ensembl chr 3:183,000,521...183,076,339

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

EXP

Methapyrilene results in increased expression of APEX1 mRNA

PMID:15890375 PMID:28935588

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

adipocyte plasma membrane associated protein

increases methylation

ISO

Methapyrilene results in increased methylation of APMAP exon

NCBI chr 3:159,869,451...159,897,727
Ensembl chr 3:159,869,451...159,897,726

G

apolipoprotein A1

decreases expression

ISO

Methapyrilene results in decreased expression of APOA1 mRNA

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein A2

increases expression

EXP

Methapyrilene results in increased expression of APOA2 mRNA

NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410

G

apolipoprotein B

decreases expression

EXP

Methapyrilene results in decreased expression of APOB mRNA

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C1

decreases expression
increases expression

EXP

Methapyrilene results in decreased expression of APOC1 mRNA
Methapyrilene results in increased expression of APOC1 mRNA

PMID:15120968 PMID:30467583

NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155

G

apolipoprotein C3

decreases expression

EXP

Methapyrilene results in decreased expression of APOC3 mRNA

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

apolipoprotein D

increases methylation

ISO

Methapyrilene results in increased methylation of APOD intron

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

apolipoprotein M

increases expression

EXP

Methapyrilene results in increased expression of APOM mRNA

NCBI chr20:3,695,618...3,698,218
Ensembl chr20:3,692,737...3,698,218

G

apolipoprotein O

increases methylation

ISO

Methapyrilene results in increased methylation of APOO intron

NCBI chr X:63,151,736...63,256,696
Ensembl chr X:63,151,814...63,256,690

G

amyloid beta precursor protein

increases expression

EXP

Methapyrilene results in increased expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 1

increases methylation

ISO

Methapyrilene results in increased methylation of AQP1 intron

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

androgen receptor

increases methylation

ISO

Methapyrilene results in increased methylation of AR intron

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

activity-regulated cytoskeleton-associated protein

increases methylation

ISO

Methapyrilene results in increased methylation of ARC intron

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

archain 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARCN1 mRNA

NCBI chr 8:53,954,401...53,979,005
Ensembl chr 8:53,954,404...53,979,005

G

ARF guanine nucleotide exchange factor 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARFGEF1 mRNA

NCBI chr 5:13,764,507...13,859,237
Ensembl chr 5:13,764,975...13,859,237

G

ARF related protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARFRP1 mRNA

NCBI chr 3:188,844,013...188,851,473
Ensembl chr 3:188,845,511...188,851,431

G

arginase 1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of ARG1 protein
Methapyrilene results in decreased expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

Rho GTPase activating protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARHGAP1 mRNA

NCBI chr 3:98,077,064...98,099,163
Ensembl chr 3:98,077,150...98,099,154

G

Rho GTPase activating protein 19

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGAP19 intron

NCBI chr 1:250,519,703...250,566,705
Ensembl chr 1:250,530,214...250,580,190

G

Rho GTPase activating protein 26

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGAP26 intron

NCBI chr18:30,702,602...31,489,047
Ensembl chr18:31,089,787...31,489,047

G

Rho GTPase activating protein 27

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGAP27 intron; Methapyrilene results in decreased methylation of ARHGAP27 promoter

NCBI chr10:88,780,527...88,813,275
Ensembl chr10:88,780,527...88,814,616

G

Rho GTPase activating protein 31

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGAP31 intron

NCBI chr11:75,544,176...75,657,087
Ensembl chr11:75,544,040...75,661,076

G

Rho GTPase activating protein 35

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGAP35 intron

NCBI chr 1:86,330,566...86,447,414
Ensembl chr 1:86,330,566...86,447,414

G

Rho GTPase activating protein 39

affects methylation

ISO

Methapyrilene affects the methylation of ARHGAP39 intron

NCBI chr 7:110,326,918...110,419,500
Ensembl chr 7:110,326,918...110,419,460

G

Rho GTPase activating protein 42

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGAP42 intron

NCBI chr 8:14,436,478...14,666,588
Ensembl chr 8:14,419,256...14,666,385

G

Rho GTPase activating protein 44

increases methylation

EXP
ISO

Methapyrilene results in increased methylation of ARHGAP44 gene
Methapyrilene results in increased methylation of ARHGAP44 intron

PMID:26431795 PMID:30157460

NCBI chr10:50,154,724...50,322,027
Ensembl chr10:50,154,724...50,321,897

G

Rho GTPase activating protein 45

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGAP45 3' UTR

NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:10,325,539...10,341,890

G

Rho GDP dissociation inhibitor beta

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGDIB intron

NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068

G

Rho guanine nucleotide exchange factor 10

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGEF10 intron

NCBI chr16:81,349,429...81,440,439
Ensembl chr16:81,349,429...81,440,054

G

Rho guanine nucleotide exchange factor 11

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGEF11 exon

NCBI chr 2:175,372,269...175,493,852
Ensembl chr 2:175,372,290...175,493,852

G

Rho guanine nucleotide exchange factor 15

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGEF15 3' UTR

NCBI chr10:54,149,372...54,162,128
Ensembl chr10:54,149,372...54,162,128

G

Rho/Rac guanine nucleotide exchange factor 2

decreases expression

EXP

Methapyrilene results in decreased expression of ARHGEF2 mRNA

NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:176,358,904...176,417,646

G

Rho guanine nucleotide exchange factor 3

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGEF3 intron

NCBI chr16:2,308,311...2,588,634
Ensembl chr16:2,308,400...2,588,819

G

Rho guanine nucleotide exchange factor 37

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGEF37 intron

NCBI chr18:57,205,621...57,271,284
Ensembl chr18:57,230,117...57,271,031

G

Rho guanine nucleotide exchange factor 4

increases methylation

ISO

Methapyrilene results in increased methylation of ARHGEF4 intron

NCBI chr 9:44,357,716...44,500,959
Ensembl chr 9:44,357,736...44,501,550

G

Rac/Cdc42 guanine nucleotide exchange factor 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARHGEF6 intron

NCBI chr X:140,182,734...140,302,812
Ensembl chr X:140,182,734...140,344,458

G

AT-rich interaction domain 1B

increases methylation
affects expression

ISO
EXP

Methapyrilene results in increased methylation of ARID1B intron
Methapyrilene affects the expression of ARID1B mRNA

PMID:30157460 PMID:30467583

NCBI chr 1:47,973,199...48,328,793
Ensembl chr 1:47,973,997...48,328,793

G

AT-rich interaction domain 2

increases methylation

ISO

Methapyrilene results in increased methylation of ARID2 intron

NCBI chr 7:129,326,371...129,443,813
Ensembl chr 7:129,324,137...129,443,187

G

AT-rich interaction domain 3A

increases methylation

ISO

Methapyrilene results in increased methylation of ARID3A intron

NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:10,405,631...10,427,926

G

AT-rich interaction domain 3C

increases methylation

ISO

Methapyrilene results in increased methylation of ARID3C promoter

NCBI chr 5:61,685,511...61,692,821
Ensembl chr 5:61,685,511...61,692,821

G

ARF like GTPase 14 effector protein like

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARL14EPL intron

NCBI chr18:41,866,458...41,897,431
Ensembl chr18:41,867,524...41,897,427

G

ARF like GTPase 15

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARL15 intron

NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:47,094,900...47,555,666

G

ARL6 interacting reticulophagy regulator 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARL6IP1 mRNA

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232

G

armadillo repeat containing, X-linked 1

decreases expression

EXP

Methapyrilene results in decreased expression of ARMCX1 mRNA

NCBI chr X:102,192,225...102,196,130
Ensembl chr X:102,192,015...102,199,115

G

armadillo repeat containing, X-linked 3

decreases expression

EXP

Methapyrilene results in decreased expression of ARMCX3 mRNA

NCBI chr X:102,230,464...102,234,017
Ensembl chr X:102,219,848...102,263,297

G

arrestin, beta 1

increases methylation

ISO

Methapyrilene results in increased methylation of ARRB1 intron

NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859

G

arrestin, beta 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARRB2 intron

NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487

G

arrestin domain containing 4

decreases expression

EXP

Methapyrilene results in decreased expression of ARRDC4 mRNA

NCBI chr 1:131,779,436...131,793,438
Ensembl chr 1:131,779,437...131,793,565

G

arylsulfatase B

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of ARSB mRNA
Methapyrilene results in increased methylation of ARSB intron

PMID:30157460 PMID:30467583

NCBI chr 2:26,736,395...26,895,682
Ensembl chr 2:26,736,957...26,897,611

G

arylsulfatase G

decreases methylation

ISO

Methapyrilene results in decreased methylation of ARSG intron

NCBI chr10:94,912,094...95,063,021
Ensembl chr10:94,913,152...95,042,447

G

ADP-ribosyltransferase 5

increases methylation

ISO

Methapyrilene results in increased methylation of ART5 intron

NCBI chr 1:165,885,344...165,895,306
Ensembl chr 1:165,885,280...165,895,306

G

N-acylsphingosine amidohydrolase 1

increases expression

EXP
ISO

Methapyrilene results in increased expression of ASAH1 mRNA

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

increases methylation

ISO

Methapyrilene results in increased methylation of ASAP2 intron

NCBI chr 6:46,386,605...46,549,669
Ensembl chr 6:46,386,605...46,549,669

G

ankyrin repeat and SOCS box-containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of ASB2 intron; Methapyrilene results in increased methylation of ASB2 promoter

NCBI chr 6:128,239,550...128,275,833
Ensembl chr 6:128,239,552...128,266,321

G

ankyrin repeat and SOCS box-containing 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ASB4 intron

NCBI chr 4:34,473,527...34,511,163
Ensembl chr 4:34,473,408...34,512,888

G

ankyrin repeat and SOCS box-containing 7

increases methylation

ISO

Methapyrilene results in increased methylation of ASB7 intron

NCBI chr 1:129,621,462...129,677,788
Ensembl chr 1:129,635,330...129,677,505

G

activating signal cointegrator 1 complex subunit 3

decreases expression

EXP

Methapyrilene results in decreased expression of ASCC3 mRNA

NCBI chr20:55,089,430...55,372,374
Ensembl chr20:55,255,503...55,372,374

G

anti-silencing function 1B histone chaperone

decreases methylation

ISO

Methapyrilene results in decreased methylation of ASF1B intron

NCBI chr19:41,085,786...41,100,352
Ensembl chr19:41,086,114...41,100,352

G

asialoglycoprotein receptor 2

increases methylation

ISO

Methapyrilene results in increased methylation of ASGR2 intron

NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263

G

ASH1 like histone lysine methyltransferase

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of ASH1L mRNA
Methapyrilene results in decreased methylation of ASH1L intron

PMID:30157460 PMID:30467583

NCBI chr 2:176,644,393...176,780,848
Ensembl chr 2:176,644,924...176,780,847

G

ASH2 like histone lysine methyltransferase complex subunit

decreases expression

EXP

Methapyrilene results in decreased expression of ASH2L mRNA

NCBI chr16:72,943,527...72,966,791
Ensembl chr16:72,944,949...72,967,839

G

acid sensing ion channel subunit 2

increases methylation

ISO

Methapyrilene results in increased methylation of ASIC2 intron

NCBI chr10:66,368,308...67,438,237
Ensembl chr10:66,368,310...66,636,245

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

EXP

Methapyrilene results in decreased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

asparaginase

increases methylation
decreases expression

ISO

Methapyrilene results in increased methylation of ASPG gene
Methapyrilene results in decreased expression of ASPG mRNA

NCBI chr 6:136,997,832...137,017,417
Ensembl chr 6:136,998,023...137,017,417

G

ASPSCR1 tether for SLC2A4, UBX domain containing

decreases methylation

ISO

Methapyrilene results in decreased methylation of ASPSCR1 intron

NCBI chr10:106,450,600...106,488,231
Ensembl chr10:106,450,567...106,488,579

G

argininosuccinate synthase 1

decreases expression
increases methylation
increases expression

EXP
ISO

Methapyrilene results in decreased expression of ASS1 mRNA
Methapyrilene results in increased methylation of ASS1 gene
Methapyrilene results in increased expression of ASS1 protein

PMID:30467583 PMID:31555880

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

astacin like metalloendopeptidase

increases methylation

ISO

Methapyrilene results in increased methylation of ASTL intron

NCBI chr 3:135,016,444...135,032,177
Ensembl chr 3:135,016,444...135,032,177

G

astrotactin 2

increases methylation

ISO

Methapyrilene results in increased methylation of ASTN2 intron

NCBI chr 5:83,772,988...84,759,439
Ensembl chr 5:83,773,633...84,759,485

G

ASXL transcriptional regulator 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ASXL2 intron

NCBI chr 6:32,090,497...32,234,487
Ensembl chr 6:32,145,607...32,227,851

G

ATCAY kinesin light chain interacting caytaxin

increases methylation

ISO

Methapyrilene results in increased methylation of ATCAY intron

NCBI chr 7:9,138,485...9,162,249
Ensembl chr 7:9,138,587...9,163,370

G

arginyltransferase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ATE1 mRNA

NCBI chr 1:194,391,843...194,514,284
Ensembl chr 1:194,391,843...194,511,348

G

activating transcription factor 3

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of ATF3 mRNA
Methapyrilene results in increased methylation of ATF3 intron

PMID:15890375 PMID:22484513 PMID:30157460

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

increases expression

EXP

Methapyrilene results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

decreases expression

EXP

Methapyrilene results in decreased expression of ATF6 mRNA

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

autophagy related 4C, cysteine peptidase

decreases expression

EXP

Methapyrilene results in decreased expression of ATG4C mRNA

NCBI chr 5:118,977,594...119,050,894
Ensembl chr 5:118,982,918...119,052,695

G

atonal bHLH transcription factor 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATOH8 intron

NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379

G

atos homolog A

increases expression

EXP

Methapyrilene results in increased expression of ATOSA mRNA

NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:84,575,370...84,653,091

G

ATPase phospholipid transporting 10A (putative)

increases methylation

ISO

Methapyrilene results in increased methylation of ATP10A intron

NCBI chr 1:118,692,456...118,866,117
Ensembl chr 1:118,692,478...118,866,114

G

ATPase phospholipid transporting 10B

increases methylation

ISO

Methapyrilene results in increased methylation of ATP10B intron

NCBI chr10:27,996,729...28,252,801
Ensembl chr10:27,910,295...28,251,450

G

ATPase phospholipid transporting 11A

affects methylation
decreases expression

ISO
EXP

Methapyrilene affects the methylation of ATP11A intron
Methapyrilene results in decreased expression of ATP11A mRNA

PMID:30157460 PMID:30467583

NCBI chr16:83,359,884...83,469,807
Ensembl chr16:83,359,884...83,469,767

G

ATPase phospholipid transporting 11C

increases methylation

ISO

Methapyrilene results in increased methylation of ATP11C intron

NCBI chr X:143,600,763...143,788,407
Ensembl chr X:143,600,767...143,788,432

G

ATPase cation transporting 13A2

increases methylation

ISO

Methapyrilene results in increased methylation of ATP13A2 intron

NCBI chr 5:158,575,727...158,595,157
Ensembl chr 5:158,575,749...158,595,156

G

ATPase Na+/K+ transporting subunit alpha 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATP1A2 exon

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases methylation

ISO

Methapyrilene results in increased methylation of ATP2A3 polyA tail

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278

G

ATPase plasma membrane Ca2+ transporting 2

increases methylation

ISO

Methapyrilene results in increased methylation of ATP2B2 intron

NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:148,450,207...148,696,239

G

ATPase plasma membrane Ca2+ transporting 3

increases methylation

ISO

Methapyrilene results in increased methylation of ATP2B3 intron

NCBI chr X:156,367,582...156,464,085
Ensembl chr X:156,367,852...156,438,153

G

ATP synthase F1 subunit beta

decreases expression
increases expression
multiple interactions

EXP

Methapyrilene results in decreased expression of ATP5F1B mRNA
Methapyrilene results in increased expression of ATP5F1B protein
[Diethylnitrosamine co-treated with Methapyrilene] results in decreased expression of ATP5F1B protein

PMID:28903497 PMID:30467583

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase peripheral stalk subunit d

increases methylation

ISO

Methapyrilene results in increased methylation of ATP5PD intron

NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954

G

ATP synthase peripheral stalk subunit OSCP

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATP5PO intron

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520

G

ATPase H+ transporting V0 subunit a4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATP6V0A4 intron

NCBI chr 4:67,727,145...67,809,092
Ensembl chr 4:67,727,145...67,809,092

G

ATPase H+ transporting V0 subunit D1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATP6V0D1 intron

NCBI chr19:50,313,268...50,357,248
Ensembl chr19:50,313,273...50,357,395

G

ATPase H+ transporting V0 subunit D2

increases methylation

ISO

Methapyrilene results in increased methylation of ATP6V0D2 intron

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

ATPase H+ transporting V1 subunit B1

increases methylation

ISO

Methapyrilene results in increased methylation of ATP6V1B1 intron

NCBI chr 4:117,781,444...117,800,103
Ensembl chr 4:117,781,444...117,800,103

G

ATPase H+ transporting V1 subunit B2

increases expression

EXP

Methapyrilene results in increased expression of ATP6V1B2 mRNA

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ATPase copper transporting alpha

affects methylation

ISO

Methapyrilene affects the methylation of ATP7A intron

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

ATPase copper transporting beta

increases methylation

ISO

Methapyrilene results in increased methylation of ATP7B intron

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

ATPase phospholipid transporting 8A2

increases methylation

ISO

Methapyrilene results in increased methylation of ATP8A2 intron

NCBI chr15:37,993,507...38,526,408
Ensembl chr15:38,002,305...38,526,212

G

ATPase phospholipid transporting 8B1

increases expression

EXP

Methapyrilene results in increased expression of ATP8B1 mRNA

NCBI chr18:60,286,605...60,427,862
Ensembl chr18:60,288,464...60,427,027

G

ATPase phospholipid transporting 8B3

increases methylation

ISO

Methapyrilene results in increased methylation of ATP8B3 intron

NCBI chr 7:9,823,496...9,846,137
Ensembl chr 7:9,826,275...9,846,195

G

ATPase, class I, type 8B, member 5

increases expression

ISO

Methapyrilene results in increased expression of ATP8B5P mRNA

NCBI chr 5:62,302,213...62,415,843
Ensembl chr 5:62,302,275...62,415,834

G

attractin like 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ATRNL1 intron

NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:266,675,852...267,216,842

G

ataxin 7-like 2

increases methylation

ISO

Methapyrilene results in increased methylation of ATXN7L2 exon

NCBI chr 2:198,527,066...198,535,899
Ensembl chr 2:198,527,066...198,534,062

G

aurora kinase A and ninein interacting protein

decreases methylation

ISO

Methapyrilene results in decreased methylation of AUNIP intron

NCBI chr 5:152,006,021...152,018,614
Ensembl chr 5:152,006,042...152,020,190

G

activator of transcription and developmental regulator AUTS2

affects methylation

ISO

Methapyrilene affects the methylation of AUTS2 intron

NCBI chr12:29,739,138...30,830,386
Ensembl chr12:29,740,523...30,830,386

G

advillin

decreases methylation

ISO

Methapyrilene results in decreased methylation of AVIL intron

NCBI chr 7:64,711,294...64,729,436
Ensembl chr 7:64,711,403...64,729,436

G

AVL9 cell migration associated

increases methylation

ISO

Methapyrilene results in increased methylation of AVL9 intron

NCBI chr 4:87,291,062...87,338,537
Ensembl chr 4:87,291,798...87,331,916

G

Axl receptor tyrosine kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of AXL exon

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

antizyme inhibitor 1

increases expression

EXP

Methapyrilene results in increased expression of AZIN1 mRNA

PMID:16393664 PMID:30467583

NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515

G

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

decreases expression

EXP

Methapyrilene results in decreased expression of B3GALNT1 mRNA

NCBI chr 2:156,157,234...156,187,037
Ensembl chr 2:156,156,265...156,188,404

G

Beta-1,3-galactosyltransferase 5

increases methylation

ISO

Methapyrilene results in increased methylation of B3GALT5 exon; Methapyrilene results in increased methylation of B3GALT5 intron

NCBI chr11:49,053,959...49,100,398
Ensembl chr11:49,006,560...49,101,283

G

beta-1,3-glucuronyltransferase 1

increases methylation

ISO

Methapyrilene results in increased methylation of B3GAT1 intron

NCBI chr 8:33,362,791...33,390,446
Ensembl chr 8:33,363,048...33,390,443

G

beta-1,3-glucuronyltransferase 2

increases methylation

ISO

Methapyrilene results in increased methylation of B3GAT2 intron

NCBI chr 9:33,663,482...33,746,466
Ensembl chr 9:33,663,482...33,746,466

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of QTGAL intron

NCBI chr10:107,363,036...107,431,988
Ensembl chr10:107,371,442...107,431,908

G

beta-1,4-N-acetyl-galactosaminyl transferase 1

decreases expression

EXP

Methapyrilene results in decreased expression of B4GALNT1 mRNA

NCBI chr 7:64,873,909...64,881,512
Ensembl chr 7:64,874,022...64,881,516

G

beta-1,4-N-acetyl-galactosaminyl transferase 3

affects methylation

ISO

Methapyrilene affects the methylation of B4GALNT3 intron

NCBI chr 4:155,081,261...155,181,255
Ensembl chr 4:155,081,261...155,181,244

G

beta-1,4-N-acetyl-galactosaminyl transferase 4

increases methylation

ISO

Methapyrilene results in increased methylation of B4GALNT4 intron

NCBI chr 1:205,600,989...205,611,889
Ensembl chr 1:205,600,989...205,611,889

G

beta-1,4-galactosyltransferase 1

affects methylation

ISO

Methapyrilene affects the methylation of B4GALT1 intron

NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445

G

beta-1,4-galactosyltransferase 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of B4GALT2 intron

NCBI chr 5:136,697,981...136,707,783
Ensembl chr 5:136,697,981...136,710,422

G

bile acid CoA:amino acid N-acyltransferase

decreases expression

EXP

Methapyrilene results in decreased expression of BAAT mRNA

PMID:28529062 PMID:30467583

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181

G

beta-secretase 2

affects methylation

ISO

Methapyrilene affects the methylation of BACE2 intron

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:50,176,621...50,259,008

G

BAG cochaperone 1

increases expression

EXP

Methapyrilene results in increased expression of BAG1 mRNA

NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:60,864,476...60,878,161

G

BAG cochaperone 6

increases methylation

ISO

Methapyrilene results in increased methylation of BAG6 exon

NCBI chr20:3,680,607...3,693,329
Ensembl chr20:3,680,607...3,693,329

G

BMP and activin membrane-bound inhibitor

increases expression

EXP

Methapyrilene results in increased expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Methapyrilene results in increased expression of BAX mRNA

PMID:15890375 PMID:17450226

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

gamma-butyrobetaine hydroxylase 1

decreases expression

EXP

Methapyrilene results in decreased expression of BBOX1 mRNA

NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064

G

Bardet-Biedl syndrome 2

decreases expression

EXP

Methapyrilene results in decreased expression of BBS2 mRNA

NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921

G

Bardet-Biedl syndrome 5

decreases expression

EXP

Methapyrilene results in decreased expression of BBS5 mRNA

NCBI chr 3:74,818,104...74,839,658
Ensembl chr 3:74,818,473...74,857,023

G

BBX high mobility group box domain containing

increases methylation

ISO

Methapyrilene results in increased methylation of BBX intron

NCBI chr11:63,850,034...64,097,700
Ensembl chr11:63,850,018...64,093,265

G

B-cell receptor-associated protein 31

decreases methylation

ISO

Methapyrilene results in decreased methylation of BCAP31 intron

NCBI chr X:156,548,911...156,581,002
Ensembl chr X:156,548,911...156,579,371

G

BCAR1 scaffold protein, Cas family member

decreases methylation

ISO

Methapyrilene results in decreased methylation of BCAR1 intron

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

BCAS3, microtubule associated cell migration factor

increases methylation

ISO

Methapyrilene results in increased methylation of BCAS3 intron

NCBI chr10:70,711,084...71,170,492
Ensembl chr10:70,711,525...71,170,803

G

branched chain amino acid transaminase 1

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of BCAT1 mRNA
Methapyrilene results in increased methylation of BCAT1 intron

PMID:23558518 PMID:30157460

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression
affects expression

EXP

Methapyrilene results in decreased expression of BCKDHA mRNA
Methapyrilene affects the expression of BCKDHA protein

PMID:16393664 PMID:30467583

NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749

G

branched chain keto acid dehydrogenase E1 subunit beta

increases methylation

ISO

Methapyrilene results in increased methylation of BCKDHB intron

NCBI chr 8:93,725,277...93,907,799
Ensembl chr 8:93,725,275...93,907,798

G

branched chain ketoacid dehydrogenase kinase

decreases expression

EXP

Methapyrilene results in decreased expression of BCKDK mRNA

NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453

G

BCL11 transcription factor B

increases methylation

ISO

Methapyrilene results in increased methylation of BCL11B intron

NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301

G

Bcl2-like 14

increases methylation

ISO

Methapyrilene results in increased methylation of BCL2L14 intron

NCBI chr 4:168,948,919...168,989,450
Ensembl chr 4:168,948,946...168,990,079

G

Bcl2-like 2

decreases expression

EXP

Methapyrilene results in decreased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

BCL6, transcription repressor

decreases expression

EXP

Methapyrilene results in decreased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BAF chromatin remodeling complex subunit BCL7A

decreases methylation

ISO

Methapyrilene results in decreased methylation of BCL7A intron

NCBI chr12:38,872,851...38,904,770
Ensembl chr12:38,872,851...38,904,770

G

BAF chromatin remodeling complex subunit BCL7C

increases methylation

ISO

Methapyrilene results in increased methylation of BCL7C polyA tail

NCBI chr 1:191,703,432...191,754,751
Ensembl chr 1:191,691,089...191,754,641

G

BCL9, transcription coactivator

increases methylation

ISO

Methapyrilene results in increased methylation of BCL9 intron

NCBI chr 2:187,449,425...187,475,241
Ensembl chr 2:187,449,425...187,475,241

G

3-hydroxybutyrate dehydrogenase 1

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of BDH1 mRNA
Methapyrilene results in increased methylation of BDH1 intron

PMID:16393664 PMID:30157460

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

brain-enriched guanylate kinase-associated

decreases methylation

ISO

Methapyrilene results in decreased methylation of BEGAIN intron

NCBI chr 6:133,708,010...133,744,264
Ensembl chr 6:133,708,007...133,744,526

G

BEN domain containing 5

increases methylation

ISO

Methapyrilene results in increased methylation of BEND5 intron

NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906

G

Bet1 golgi vesicular membrane trafficking protein

decreases expression

EXP

Methapyrilene results in decreased expression of BET1 mRNA

NCBI chr 4:33,070,892...33,081,162
Ensembl chr 4:33,070,891...33,081,164

G

brain expressed X-linked 3

increases expression

EXP

Methapyrilene results in increased expression of BEX3 mRNA

NCBI chr X:104,064,896...104,066,425
Ensembl chr X:104,064,515...104,075,906

G

beaded filament structural protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of BFSP1 intron

NCBI chr 3:151,648,588...151,706,153
Ensembl chr 3:151,648,588...151,682,837

G

biglycan

increases methylation

ISO

Methapyrilene results in increased methylation of BGN intron

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

basic helix-loop-helix family, member a15

decreases expression

EXP

Methapyrilene results in decreased expression of BHLHA15 mRNA

NCBI chr12:15,534,123...15,538,299
Ensembl chr12:15,534,123...15,538,515

G

betaine-homocysteine S-methyltransferase

decreases expression

EXP

Methapyrilene results in decreased expression of BHMT mRNA

NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:26,594,854...26,614,715

G

betaine-homocysteine S-methyltransferase 2

decreases expression

EXP

Methapyrilene results in decreased expression of BHMT2 mRNA

NCBI chr 2:26,630,502...26,647,450
Ensembl chr 2:26,630,510...26,651,326

G

BICD family like cargo adaptor 1

increases methylation

ISO

Methapyrilene results in increased methylation of BICDL1 intron

NCBI chr12:46,537,525...46,626,876
Ensembl chr12:46,538,396...46,628,866

G

BICRA like chromatin remodeling complex associated protein

increases methylation

ISO

Methapyrilene results in increased methylation of BICRAL intron

NCBI chr 9:21,597,886...21,682,985
Ensembl chr 9:21,597,855...21,682,983

G

bridging integrator 3

affects methylation

ISO

Methapyrilene affects the methylation of BIN3 intron

NCBI chr15:51,583,474...51,622,329
Ensembl chr15:51,583,481...51,622,329

G

BLACAT1 overlapping LEMD1 locus

decreases methylation

ISO

Methapyrilene results in decreased methylation of BLACAT1 intron

NCBI chr13:46,189,091...46,202,506
Ensembl chr13:46,197,208...46,197,306

G

BLK proto-oncogene, Src family tyrosine kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of BLK exon

NCBI chr15:41,802,701...41,841,004
Ensembl chr15:41,802,994...41,840,982

G

biogenesis of lysosomal organelles complex 1 subunit 6

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of BLOC1S6 polyA tail
Methapyrilene results in decreased expression of BLOC1S6 mRNA

PMID:30157460 PMID:30467583

NCBI chr 3:130,269,979...130,280,109
Ensembl chr 3:130,268,442...130,281,360

G

bridge-like lipid transfer protein family member 3A

increases methylation

ISO

Methapyrilene results in increased methylation of BLTP3A promoter

NCBI chr20:5,912,033...5,956,404
Ensembl chr20:5,912,106...5,956,403

G

bridge-like lipid transfer protein family member 3B

decreases expression

EXP

Methapyrilene results in decreased expression of BLTP3B mRNA

NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:26,068,955...26,149,083

G

bone morphogenetic protein receptor type 1A

decreases methylation

ISO

Methapyrilene results in decreased methylation of BMPR1A 3' UTR

NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861

G

bone morphogenetic protein receptor type 2

increases methylation

ISO

Methapyrilene results in increased methylation of BMPR2 intron

NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350

G

BOC cell adhesion associated, oncogene regulated

increases methylation

ISO

Methapyrilene results in increased methylation of BOC exon

NCBI chr11:69,628,703...69,704,009
Ensembl chr11:69,628,660...69,704,004

G

BCL2 family apoptosis regulator BOK

affects methylation

ISO

Methapyrilene affects the methylation of BOK 3' UTR

NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833

G

biphenyl hydrolase like

decreases expression

EXP

Methapyrilene results in decreased expression of BPHL mRNA

NCBI chr17:31,006,283...31,042,631
Ensembl chr17:31,004,972...31,042,632

G

3'(2'), 5'-bisphosphate nucleotidase 2

decreases expression

EXP

Methapyrilene results in decreased expression of BPNT2 mRNA

NCBI chr 5:22,573,241...22,600,126
Ensembl chr 5:22,570,165...22,600,126

G

BRCA1/BRCA2-containing complex subunit 3

decreases expression

EXP

Methapyrilene results in decreased expression of BRCC3 mRNA

NCBI chr 9:2,073,927...2,076,469
Ensembl chr 9:2,073,184...2,084,185

G

bromodomain containing 2

increases expression

EXP

Methapyrilene results in increased expression of BRD2 mRNA

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290

G

bromodomain containing 8

increases methylation
decreases expression

EXP

Methapyrilene results in increased methylation of BRD8 gene
Methapyrilene results in decreased expression of BRD8 mRNA

PMID:26431795 PMID:30467583

NCBI chr18:26,455,824...26,504,106
Ensembl chr18:26,455,512...26,504,006

G

BRF1 general transcription factor IIIB subunit

increases methylation

ISO

Methapyrilene results in increased methylation of BRF1 intron

NCBI chr 6:137,854,055...137,902,629
Ensembl chr 6:137,855,449...137,902,386

G

brain protein I3

increases methylation

ISO

Methapyrilene results in increased methylation of BRI3 intron

NCBI chr12:15,454,673...15,478,319
Ensembl chr12:15,454,673...15,478,319

G

BMP/retinoic acid inducible neural specific 1

increases methylation

ISO

Methapyrilene results in increased methylation of BRINP1 intron

NCBI chr 5:87,363,621...87,565,580
Ensembl chr 5:87,364,050...87,508,256

G

BMP/retinoic acid inducible neural specific 2

increases methylation

ISO

Methapyrilene results in increased methylation of BRINP2 exon; Methapyrilene results in increased methylation of BRINP2 intron

NCBI chr13:72,964,498...73,065,312
Ensembl chr13:72,964,502...73,065,294

G

BMP/retinoic acid inducible neural specific 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of BRINP3 intron

NCBI chr13:60,964,127...61,397,044
Ensembl chr13:60,966,100...61,397,039

G

BR serine/threonine kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of BRSK2 intron

NCBI chr 1:206,465,040...206,518,156
Ensembl chr 1:206,465,040...206,518,156

G

bassoon (presynaptic cytomatrix protein)

increases methylation

ISO

Methapyrilene results in increased methylation of BSN exon

NCBI chr 8:117,663,447...117,754,412
Ensembl chr 8:117,670,334...117,754,412

G

BTB domain containing 3

increases methylation

ISO

Methapyrilene results in increased methylation of BTBD3 promoter

NCBI chr 3:146,044,053...146,074,189
Ensembl chr 3:146,044,096...146,074,635

G

BTG anti-proliferation factor 2

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of BTG2 mRNA
Methapyrilene results in decreased expression of BTG2 mRNA

PMID:15890375 PMID:21813463 PMID:28935588 PMID:30467583

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

BTG anti-proliferation factor 4

increases methylation

ISO

Methapyrilene results in increased methylation of BTG4 intron

NCBI chr 8:60,307,090...60,322,167
Ensembl chr 8:60,317,121...60,322,167

G

Bruton tyrosine kinase

increases methylation

ISO

Methapyrilene results in increased methylation of BTK intron

NCBI chr X:102,016,070...102,055,448
Ensembl chr X:102,016,074...102,055,143

G

BUD23, rRNA methyltransferase and ribosome maturation factor

increases methylation

ISO

Methapyrilene results in increased methylation of BUD23 intron

NCBI chr12:27,266,093...27,277,300
Ensembl chr12:27,265,521...27,277,297

G

similar to human chromosome 16 open reading frame 89

increases methylation

ISO

Methapyrilene results in increased methylation of C16ORF89 5' UTR

NCBI chr10:10,856,320...10,877,515
Ensembl chr10:10,868,419...10,877,515

G

similar to human chromosome 13 open reading frame 42

increases methylation

ISO

Methapyrilene results in increased methylation of C13ORF42 intron

NCBI chr15:40,852,879...40,877,320
Ensembl chr15:40,854,229...40,876,536

G

similar to human chromosome 19 open reading frame 44

decreases methylation

ISO

Methapyrilene results in decreased methylation of C19ORF44 intron

NCBI chr16:17,414,041...17,430,108
Ensembl chr16:17,414,045...17,430,183

G

similar to human chromosome 16 open reading frame 46

increases methylation

ISO

Methapyrilene results in increased methylation of C16ORF46 intron

NCBI chr19:61,931,114...61,941,517
Ensembl chr19:61,931,116...61,941,517

G

similar to human chromosome 16 open reading frame 74

increases methylation

ISO

Methapyrilene results in increased methylation of C16ORF74 polyA tail

NCBI chr19:65,568,997...65,594,994
Ensembl chr19:65,568,997...65,595,460

G

C1GALT1-specific chaperone 1

increases methylation

ISO

Methapyrilene results in increased methylation of C1GALT1C1 intron

NCBI chr X:122,243,736...122,248,217
Ensembl chr X:122,234,454...122,248,422

G

similar to human chromosome 11 open reading frame 98

decreases methylation

ISO

Methapyrilene results in decreased methylation of C11ORF98 polyA tail

NCBI chr 1:215,211,658...215,213,687
Ensembl chr 1:215,211,688...215,213,687

G

similar to human chromosome 19 open reading frame 18

increases methylation

ISO

Methapyrilene results in increased methylation of C19ORF18 intron

NCBI chr 1:82,094,513...82,122,109
Ensembl chr 1:82,098,305...82,122,119

G

C1q and TNF related 2

increases methylation

ISO

Methapyrilene results in increased methylation of C1QTNF2 intron

NCBI chr10:28,443,326...28,460,400
Ensembl chr10:28,443,425...28,460,395

G

C1q and TNF related 4

increases methylation

ISO

Methapyrilene results in increased methylation of C1QTNF4 promoter

NCBI chr 3:97,310,220...97,328,818
Ensembl chr 3:97,327,670...97,342,587

G

complement C2

decreases methylation

ISO

Methapyrilene results in decreased methylation of C2 intron

NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,955,776...3,981,740

G

similar to human chromosome 3 open reading frame 80

decreases methylation

ISO

Methapyrilene results in decreased methylation of C3ORF80 promoter

NCBI chr 2:155,435,287...155,438,099
Ensembl chr 2:155,434,073...155,437,507

G

complement component 4 binding protein, alpha

increases expression

EXP

Methapyrilene results in increased expression of C4BPA mRNA

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement component 4 binding protein, beta

increases expression

EXP

Methapyrilene results in increased expression of C4BPB mRNA

NCBI chr13:44,673,064...44,683,781
Ensembl chr13:44,673,065...44,683,793

G

similar to human chromosome 3 open reading frame 20

increases methylation

ISO

Methapyrilene results in increased methylation of C3ORF20 intron; Methapyrilene results in increased methylation of C3ORF20 polyA tail

NCBI chr 4:125,976,326...126,027,796
Ensembl chr 4:125,980,430...126,027,791

G

complement C5a receptor 1

increases methylation

ISO

Methapyrilene results in increased methylation of C5AR1 promoter

NCBI chr 1:86,077,309...86,088,001

G

similar to human chromosome 8 open reading frame 34

increases methylation

ISO

Methapyrilene results in increased methylation of C8ORF34 intron

NCBI chr 5:12,021,000...12,560,212
Ensembl chr 5:12,021,007...12,559,772

G

complement C6

increases expression

EXP

Methapyrilene results in increased expression of C6 mRNA

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

complement C8 beta chain

increases expression

EXP

Methapyrilene results in increased expression of C8B mRNA

NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:124,761,790...124,801,516

G

complement C8 gamma chain

increases expression

EXP

Methapyrilene results in increased expression of C8G mRNA

NCBI chr 3:28,718,648...28,720,232

G

similar to human chromosome 15 open reading frame 39

increases methylation

ISO

Methapyrilene results in increased methylation of C15ORF39 intron

NCBI chr 8:66,542,269...66,551,835
Ensembl chr 8:66,542,269...66,554,782

G

complement C9

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of C9 mRNA
Methapyrilene results in increased methylation of C9 intron

PMID:30157460 PMID:30467583

NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:57,300,427...57,348,752

G

similar to human chromosome 6 open reading frame 132

increases methylation

ISO

Methapyrilene results in increased methylation of C6ORF132 intron

NCBI chr 9:21,022,482...21,058,942
Ensembl chr 9:21,023,092...21,059,125

G

carbonic anhydrase 3

decreases expression

EXP

Methapyrilene results in decreased expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

carbonic anhydrase 5A

decreases methylation

ISO

Methapyrilene results in decreased methylation of CA5A intron

NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486

G

calcium binding protein 39

decreases methylation

ISO

Methapyrilene results in decreased methylation of CAB39 intron

NCBI chr 9:93,911,099...93,972,542
Ensembl chr 9:93,911,054...93,972,542

G

calcium binding protein 39-like

increases methylation

ISO

Methapyrilene results in increased methylation of CAB39L intron

NCBI chr15:37,782,778...37,885,191
Ensembl chr15:37,782,870...37,919,742

G

calcium binding protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of CABP1 intron

NCBI chr12:47,045,914...47,109,614
Ensembl chr12:47,085,292...47,109,611

G

cache domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of CACHD1 promoter

NCBI chr 5:120,527,224...120,752,685
Ensembl chr 5:120,526,770...120,772,877

G

calcium voltage-gated channel subunit alpha1 C

increases methylation
affects methylation

ISO

Methapyrilene results in increased methylation of CACNA1C exon
Methapyrilene affects the methylation of CACNA1C intron

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762

G

calcium voltage-gated channel subunit alpha1 D

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA1D intron

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692

G

calcium voltage-gated channel subunit alpha1 G

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA1G intron

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634

G

calcium voltage-gated channel subunit alpha1 H

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA1H intron

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

calcium voltage-gated channel subunit alpha1 I

affects methylation

ISO

Methapyrilene affects the methylation of CACNA1I intron

NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:113,716,266...113,827,670

G

calcium voltage-gated channel subunit alpha1 S

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA1S intron

NCBI chr13:50,045,668...50,115,903
Ensembl chr13:50,045,668...50,115,903

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA2D2 intron

NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:116,950,907...117,081,759

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

increases methylation

ISO

Methapyrilene results in increased methylation of CACNA2D3 intron

NCBI chr16:4,105,048...4,919,037
Ensembl chr16:4,105,048...4,919,098

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of CACNA2D4 intron

NCBI chr 4:154,080,877...154,197,369
Ensembl chr 4:154,080,877...154,193,778

G

calcium voltage-gated channel auxiliary subunit gamma 2

affects methylation

ISO

Methapyrilene affects the methylation of CACNG2 intron

NCBI chr 7:111,451,605...111,579,071
Ensembl chr 7:111,455,006...111,577,757

G

calcium voltage-gated channel auxiliary subunit gamma 6

increases methylation

ISO

Methapyrilene results in increased methylation of CACNG6 intron

NCBI chr 1:74,648,342...74,663,351
Ensembl chr 1:74,648,063...74,662,753

G

CDK2-associated, cullin domain 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CACUL1 intron

NCBI chr 1:269,652,356...269,712,265
Ensembl chr 1:269,652,356...269,712,112

G

cell adhesion molecule 2

increases methylation

ISO

Methapyrilene results in increased methylation of CADM2 intron

NCBI chr11:17,994,856...18,971,895
Ensembl chr11:17,994,856...18,971,448

G

caldesmon 1

decreases expression

EXP

Methapyrilene results in decreased expression of CALD1 mRNA

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calneuron 1

affects methylation

ISO

Methapyrilene affects the methylation of CALN1 intron

NCBI chr12:31,447,964...31,939,847

G

calcium/calmodulin-dependent protein kinase ID

increases methylation

ISO

Methapyrilene results in increased methylation of CAMK1D intron

NCBI chr17:77,491,191...77,892,018
Ensembl chr17:77,491,220...77,892,012

G

calcium/calmodulin-dependent protein kinase II alpha

increases methylation

ISO

Methapyrilene results in increased methylation of CAMK2A intron

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

increases methylation

ISO

Methapyrilene results in increased methylation of CAMK2B intron

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

increases expression

EXP

Methapyrilene results in increased expression of CAMK2N1 mRNA

NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058

G

calcium/calmodulin-dependent protein kinase IV

decreases methylation

ISO

Methapyrilene results in decreased methylation of CAMK4 intron

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193

G

calcium/calmodulin-dependent protein kinase kinase 1

increases methylation

ISO

Methapyrilene results in increased methylation of CAMKK1 3' UTR

NCBI chr10:58,135,872...58,159,023
Ensembl chr10:58,135,915...58,159,010

G

CaM kinase-like vesicle-associated

increases methylation

ISO

Methapyrilene results in increased methylation of CAMKV exon

NCBI chr 8:117,505,439...117,519,785
Ensembl chr 8:117,505,408...117,519,797

G

calmodulin binding transcription activator 1

increases methylation

ISO

Methapyrilene results in increased methylation of CAMTA1 intron

NCBI chr 5:166,791,639...167,639,502
Ensembl chr 5:166,793,101...167,639,733

G

cyclase associated actin cytoskeleton regulatory protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of CAP1 intron

NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:140,427,269...140,453,470

G

capping actin protein, gelsolin like

decreases methylation

ISO

Methapyrilene results in decreased methylation of CAPG intron

NCBI chr 4:106,152,912...106,170,010
Ensembl chr 4:106,152,890...106,170,672

G

calpain 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CAPN2 intron

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625

G

calpain 8

increases methylation

ISO

Methapyrilene results in increased methylation of CAPN8 exon

NCBI chr13:96,783,640...96,847,825
Ensembl chr13:96,783,667...96,847,820

G

calpain 9

increases methylation

ISO

Methapyrilene results in increased methylation of CAPN9 exon

NCBI chr19:69,446,847...69,483,810
Ensembl chr19:69,446,847...69,483,810

G

cell cycle associated protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

capping actin protein of muscle Z-line subunit beta

increases methylation

ISO

Methapyrilene results in increased methylation of CAPZB intron

NCBI chr 5:156,718,619...156,818,623
Ensembl chr 5:156,650,432...156,818,619

G

caspase recruitment domain family, member 11

increases methylation

ISO

Methapyrilene results in increased methylation of CARD11 intron

NCBI chr12:18,735,088...18,872,045
Ensembl chr12:18,735,088...18,872,045

G

coactivator-associated arginine methyltransferase 1

increases methylation

ISO

Methapyrilene results in increased methylation of CARM1 intron

NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:28,373,362...28,418,056

G

cysteinyl-tRNA synthetase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CARS1 intron

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

cysteinyl-tRNA synthetase 2, mitochondrial

decreases methylation

ISO

Methapyrilene results in decreased methylation of CARS2 intron

NCBI chr16:84,649,617...84,689,254
Ensembl chr16:84,645,627...84,690,192

G

calcium/calmodulin dependent serine protein kinase

affects methylation

ISO

Methapyrilene affects the methylation of CASK intron

NCBI chr X:11,572,328...11,915,831
Ensembl chr X:11,572,636...11,911,948

G

caspase 12

increases expression

EXP

Methapyrilene results in increased expression of CASP12 mRNA

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases activity
increases expression
increases cleavage

EXP

Methapyrilene results in increased activity of CASP3 protein
Methapyrilene results in increased expression of CASP3 mRNA
Methapyrilene results in increased cleavage of CASP3 protein

PMID:19523481 PMID:26558467 PMID:30467583

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

EXP

Methapyrilene results in increased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 9

increases expression

EXP

Methapyrilene results in increased expression of CASP9 mRNA

Ensembl chr 5:159,391,188...159,409,648

G

Cas scaffold protein family member 4

increases methylation

ISO

Methapyrilene results in increased methylation of CASS4 intron

NCBI chr 3:181,580,954...181,620,945
Ensembl chr 3:181,581,902...181,620,945

G

calpastatin

decreases expression

EXP

Methapyrilene results in decreased expression of CAST mRNA

NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180

G

castor zinc finger 1

increases methylation

ISO

Methapyrilene results in increased methylation of CASZ1 intron

NCBI chr 5:164,527,083...164,677,037
Ensembl chr 5:164,527,112...164,677,014

G

catalase

decreases expression

EXP

Methapyrilene results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cation channel sperm associated auxiliary subunit gamma

decreases methylation

ISO

Methapyrilene results in decreased methylation of CATSPERG exon

NCBI chr 1:93,616,209...93,646,970
Ensembl chr 1:93,616,209...93,661,618

G

caveolae associated protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CAVIN1 intron

NCBI chr10:86,384,401...86,398,240
Ensembl chr10:86,384,401...86,396,383

G

CBFA2/RUNX1 partner transcriptional co-repressor 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CBFA2T2 intron

NCBI chr 3:163,397,160...163,503,409
Ensembl chr 3:163,397,185...163,503,407

G

CBFA2/RUNX1 partner transcriptional co-repressor 3

increases methylation

ISO

Methapyrilene results in increased methylation of CBFA2T3 intron

NCBI chr19:67,584,319...67,658,533
Ensembl chr19:67,589,258...67,658,136

G

Cbl proto-oncogene B

decreases expression

EXP

Methapyrilene results in decreased expression of CBLB mRNA

NCBI chr11:62,058,829...62,225,904
Ensembl chr11:62,061,653...62,225,778

G

Cbl proto-oncogene C

decreases methylation

ISO

Methapyrilene results in decreased methylation of CBLC intron

NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709

G

carbonyl reductase 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of CBR3 promoter

NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558

G

cystathionine beta synthase

decreases expression

EXP

Methapyrilene results in decreased expression of CBS mRNA

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066

G

coiled-coil and C2 domain containing 1B

increases methylation

ISO

Methapyrilene results in increased methylation of CC2D1B exon

NCBI chr 5:128,581,962...128,596,045
Ensembl chr 5:128,581,994...128,596,022

G

cell division cycle and apoptosis regulator 1

decreases expression

EXP

Methapyrilene results in decreased expression of CCAR1 mRNA

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

collagen and calcium binding EGF domains 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCBE1 intron

NCBI chr18:61,849,821...62,093,876
Ensembl chr18:61,853,149...62,094,075

G

coiled-coil domain containing 112

decreases expression

EXP

Methapyrilene results in decreased expression of CCDC112 mRNA

NCBI chr18:41,184,769...41,218,958
Ensembl chr18:41,184,769...41,218,958

G

coiled-coil domain containing 126

increases expression

EXP

Methapyrilene results in increased expression of CCDC126 mRNA

NCBI chr 4:79,628,483...79,649,513
Ensembl chr 4:79,628,412...79,649,508

G

coiled-coil domain containing 127

decreases expression

EXP

Methapyrilene results in decreased expression of CCDC127 mRNA

NCBI chr 1:30,757,010...30,764,473
Ensembl chr 1:30,757,010...30,764,473

G

coiled-coil domain containing 146

affects methylation

ISO

Methapyrilene affects the methylation of CCDC146 intron

NCBI chr 4:14,554,966...14,703,801
Ensembl chr 4:14,554,966...14,703,799

G

coiled-coil domain containing 149

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC149 intron

NCBI chr14:62,722,567...62,817,778
Ensembl chr14:62,722,600...62,817,777

G

coiled-coil domain containing 158

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC158 intron

NCBI chr14:15,695,456...15,752,896
Ensembl chr14:15,695,512...15,752,941

G

coiled-coil domain containing 167

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC167 intron

NCBI chr20:7,768,425...7,783,181
Ensembl chr20:7,753,072...7,783,181

G

coiled-coil domain containing 17

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC17 intron

NCBI chr 5:135,288,799...135,293,339
Ensembl chr 5:135,289,576...135,293,336

G

coiled-coil domain containing 178

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCDC178 intron

NCBI chr18:13,349,795...13,747,083
Ensembl chr18:13,349,399...13,746,974

G

coiled-coil domain containing 18

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC18 intron

NCBI chr14:1,646,725...1,752,581
Ensembl chr14:1,646,809...1,750,470

G

coiled-coil domain containing 30

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC30 intron

NCBI chr 5:138,212,067...138,305,465
Ensembl chr 5:138,211,227...138,304,992

G

coiled-coil domain containing 33

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC33 intron

NCBI chr 8:67,331,519...67,430,194
Ensembl chr 8:67,331,519...67,413,485

G

coiled-coil domain containing 42

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC42 exon

NCBI chr10:53,788,833...53,799,011
Ensembl chr10:53,787,810...53,808,417

G

coiled-coil domain containing 47

decreases expression

EXP

Methapyrilene results in decreased expression of CCDC47 mRNA

NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,630,106...91,648,626

G

coiled-coil domain containing 57

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC57 intron

NCBI chr10:106,591,106...106,694,740
Ensembl chr10:106,590,551...106,684,983

G

coiled-coil domain containing 63

affects methylation

ISO

Methapyrilene affects the methylation of CCDC63 intron

NCBI chr12:40,085,146...40,113,820
Ensembl chr12:40,085,183...40,114,654

G

coiled-coil domain containing 68

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of CCDC68 intron
Methapyrilene results in decreased expression of CCDC68 mRNA

PMID:30157460 PMID:30467583

NCBI chr18:65,817,232...65,859,529
Ensembl chr18:65,786,926...65,859,526

G

coiled-coil domain containing 70

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCDC70 exon

NCBI chr16:76,739,795...76,745,019
Ensembl chr16:76,738,323...76,745,869

G

coiled-coil domain containing 73

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC73 intron

NCBI chr 3:111,737,771...111,879,588
Ensembl chr 3:111,737,730...111,880,105

G

coiled-coil domain containing 85A

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCDC85A intron

NCBI chr14:106,327,580...106,560,205
Ensembl chr14:106,327,580...106,560,165

G

coiled-coil domain containing 88C

increases methylation

ISO

Methapyrilene results in increased methylation of CCDC88C intron

NCBI chr 6:125,899,337...126,019,162
Ensembl chr 6:125,899,526...126,018,865

G

coiled-coil domain containing 92

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCDC92 intron

NCBI chr12:37,457,676...37,484,080
Ensembl chr12:37,457,068...37,484,327

G

coiled-coil domain containing 97

decreases expression

EXP

Methapyrilene results in decreased expression of CCDC97 mRNA

NCBI chr 1:90,347,003...90,354,809
Ensembl chr 1:90,347,008...90,354,764

G

cholecystokinin B receptor

decreases methylation

ISO

Methapyrilene results in decreased methylation of CCKBR promoter

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745

G

C-C motif chemokine ligand 2

affects expression
increases expression

EXP

Methapyrilene affects the expression of CCL2 protein
Methapyrilene results in increased expression of CCL2 mRNA; Methapyrilene results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 25

increases methylation

ISO

Methapyrilene results in increased methylation of CCL25 intron

NCBI chr12:7,505,231...7,514,402
Ensembl chr12:7,505,235...7,514,385

G

C-C motif chemokine ligand 5

increases expression

EXP

Methapyrilene results in increased expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cellular communication network factor 1

increases expression

EXP

Methapyrilene results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cyclin B1

increases expression

EXP

Methapyrilene results in increased expression of CCNB1 mRNA

PMID:15890375 PMID:22584684

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

increases expression

EXP

Methapyrilene results in increased expression of CCNB2 mRNA

PMID:22484513 PMID:22584684

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

increases expression

EXP

Methapyrilene results in increased expression of CCND1 mRNA

PMID:15890375 PMID:22584684

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin F

increases methylation

ISO

Methapyrilene results in increased methylation of CCNF intron

NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,758,421...13,783,837

G

cyclin G1

increases expression

EXP

Methapyrilene results in increased expression of CCNG1 mRNA

PMID:15890375 PMID:28935588

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin L2

increases expression

EXP

Methapyrilene results in increased expression of CCNL2 mRNA

NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:171,699,689...171,711,231

G

cyclin Q

decreases expression

EXP

Methapyrilene results in decreased expression of CCNQ mRNA

NCBI chr10:64,144,560...64,145,723
Ensembl chr10:64,144,555...64,145,911

G

cyclin Y

affects methylation

ISO

Methapyrilene affects the methylation of CCNY intron

NCBI chr17:62,079,925...62,207,780
Ensembl chr17:62,079,925...62,207,979

G

centriolar coiled-coil protein 110

increases methylation

ISO

Methapyrilene results in increased methylation of CCP110 promoter

NCBI chr 1:182,475,571...182,504,235
Ensembl chr 1:182,476,422...182,504,232

G

C-C motif chemokine receptor 8

increases methylation

ISO

Methapyrilene results in increased methylation of CCR8 intron

NCBI chr 8:128,703,966...128,705,926
Ensembl chr 8:128,702,349...128,705,955

G

coiled-coil serine-rich protein 1

affects methylation

ISO

Methapyrilene affects the methylation of CCSER1 intron

NCBI chr 4:91,483,896...92,720,439
Ensembl chr 4:91,483,770...92,718,789

G

chaperonin containing TCP1 subunit 3

increases expression

EXP

Methapyrilene results in increased expression of CCT3 mRNA

NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:176,063,526...176,089,925

G

chaperonin containing TCP1 subunit 4

increases methylation

ISO

Methapyrilene results in increased methylation of CCT4 intron

NCBI chr14:101,193,057...101,205,935
Ensembl chr14:101,192,772...101,205,770

G

CD14 molecule

decreases expression

EXP

Methapyrilene results in decreased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

Cd2 (cytoplasmic tail) binding protein 2

decreases expression

EXP

Methapyrilene results in decreased expression of CD2BP2 mRNA

NCBI chr 1:191,239,899...191,244,395
Ensembl chr 1:191,239,901...191,243,398

G

Cd300a molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CD300A intron

NCBI chr10:100,428,826...100,441,693
Ensembl chr10:100,428,826...100,442,958

G

CD300c molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CD300C 3' UTR; Methapyrilene results in increased methylation of CD300C intron

NCBI chr10:100,727,249...100,732,202
Ensembl chr10:100,727,296...100,731,874
Ensembl chr10:100,727,296...100,731,874

G

CD302 molecule

increases expression

EXP

Methapyrilene results in increased expression of CD302 mRNA

NCBI chr 3:65,131,017...65,164,737
Ensembl chr 3:65,113,102...65,164,737

G

CD36 molecule

increases expression
decreases expression

EXP
ISO

Methapyrilene results in increased expression of CD36 mRNA
Methapyrilene results in decreased expression of CD36 mRNA

PMID:28935588 PMID:30467583

NCBI chr 4:18,209,088...18,302,142

G

CD44 molecule

increases expression

ISO

Methapyrilene results in increased expression of CD44 protein

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd6 molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CD6 intron

NCBI chr 1:216,867,767...216,906,642
Ensembl chr 1:216,867,771...216,879,432

G

Cd68 molecule

increases expression

EXP

Methapyrilene results in increased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

Cd81 molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CD81 intron

NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:207,664,885...207,681,092

G

Cd82 molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CD82 intron

NCBI chr 3:99,842,748...99,887,298
Ensembl chr 3:99,842,757...99,886,744

G

CD8 subunit beta

affects methylation

ISO

Methapyrilene affects the methylation of CD8B intron

NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:104,870,893...104,886,868

G

CD99 molecule-like 2

decreases expression

EXP

Methapyrilene results in decreased expression of CD99L2 mRNA

NCBI chr15:6,861,242...6,906,838
Ensembl chr15:6,864,268...6,906,952

G

cell division cycle 123

increases methylation

ISO

Methapyrilene results in increased methylation of CDC123 intron

NCBI chr17:77,368,376...77,412,659
Ensembl chr17:77,368,397...77,412,659

G

cell division cycle 20

increases expression

EXP

Methapyrilene results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 27

increases methylation

ISO

Methapyrilene results in increased methylation of CDC27 intron

NCBI chr10:89,900,676...89,949,770
Ensembl chr10:89,900,684...89,949,770

G

cell division cycle 34, ubiquitin conjugating enzyme

increases expression

EXP

Methapyrilene results in increased expression of CDC34 mRNA

NCBI chr 7:10,668,209...10,674,206
Ensembl chr 7:10,668,210...10,674,526

G

cell division cycle 37-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of CDC37L1 mRNA

NCBI chr 1:236,118,630...236,147,527
Ensembl chr 1:236,118,555...236,207,079

G

CDC42 binding protein kinase beta

affects methylation

ISO

Methapyrilene affects the methylation of CDC42BPB intron

NCBI chr 6:136,154,905...136,241,259
Ensembl chr 6:136,154,905...136,237,570

G

cell division cycle 45

increases methylation

ISO

Methapyrilene results in increased methylation of CDC45 intron

NCBI chr11:95,689,702...95,714,980
Ensembl chr11:95,689,919...95,714,981

G

cell division cycle 73

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDC73 intron

NCBI chr13:57,897,924...58,000,031
Ensembl chr13:57,883,983...57,999,978

G

cell division cycle associated 3

increases expression

EXP

Methapyrilene results in increased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cell division cycle associated 8

increases expression

EXP

Methapyrilene results in increased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:142,461,084...142,483,283

G

cadherin 18

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDH18 intron

NCBI chr 2:74,548,681...75,550,720
Ensembl chr 2:75,075,595...75,550,720

G

cadherin 2

decreases expression

EXP

Methapyrilene results in decreased expression of CDH2 mRNA

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cadherin 20

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDH20 intron

NCBI chr13:21,252,272...21,583,526
Ensembl chr13:21,515,123...21,584,349

G

cadherin-related 23

affects methylation
decreases expression
increases methylation

ISO

Methapyrilene affects the methylation of CDH23 intron
Methapyrilene results in decreased expression of CDH23 mRNA
Methapyrilene results in increased methylation of CDH23 gene; Methapyrilene results in increased methylation of CDH23 promoter

PMID:30157460 PMID:31555880

NCBI chr20:28,783,124...29,165,624
Ensembl chr20:28,783,564...29,165,332

G

cadherin 3

increases methylation

ISO

Methapyrilene results in increased methylation of CDH3 intron

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257

G

cadherin 4

affects methylation

ISO

Methapyrilene affects the methylation of CDH4 intron

NCBI chr 3:186,902,763...187,381,020
Ensembl chr 3:186,902,751...187,381,020

G

cadherin 8

increases methylation

ISO

Methapyrilene results in increased methylation of CDH8 intron

NCBI chr19:5,494,552...5,901,950
Ensembl chr19:5,500,221...5,902,627

G

cadherin-related family member 2

increases methylation

ISO

Methapyrilene results in increased methylation of CDHR2 intron

NCBI chr17:9,881,979...9,917,698
Ensembl chr17:9,881,979...9,917,698

G

cyclin-dependent kinase 1

increases expression

EXP

Methapyrilene results in increased expression of CDK1 mRNA

PMID:15890375 PMID:22584684

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 10

decreases expression

EXP

Methapyrilene results in decreased expression of CDK10 mRNA

NCBI chr19:68,168,040...68,184,923
Ensembl chr19:68,169,874...68,177,599

G

cyclin-dependent kinase 14

affects methylation

ISO

Methapyrilene affects the methylation of CDK14 intron

NCBI chr 4:29,619,237...30,213,651
Ensembl chr 4:29,621,217...30,213,651

G

cyclin-dependent kinase 15

increases methylation

ISO

Methapyrilene results in increased methylation of CDK15 intron

NCBI chr 9:68,205,759...68,299,218
Ensembl chr 9:68,205,678...68,293,579

G

cyclin-dependent kinase 16

increases expression

EXP

Methapyrilene results in increased expression of CDK16 mRNA

NCBI chr X:4,046,330...4,057,825
Ensembl chr X:4,026,866...4,057,380

G

cyclin-dependent kinase 4

increases expression

EXP

Methapyrilene results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDK8 intron

NCBI chr12:13,851,024...13,919,017
Ensembl chr12:13,851,024...13,917,992

G

cyclin-dependent kinase inhibitor 1A

increases expression

EXP

Methapyrilene results in increased expression of CDKN1A mRNA; Methapyrilene results in increased expression of CDKN1A protein

PMID:15890375 PMID:21813463 PMID:25242409 PMID:26558467 PMID:28935588 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 2C

increases expression

EXP

Methapyrilene results in increased expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

cyclin-dependent kinase inhibitor 3

increases expression

EXP

Methapyrilene results in increased expression of CDKN3 mRNA

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

cysteine dioxygenase type 1

decreases expression

EXP

Methapyrilene results in decreased expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

cell adhesion associated, oncogene regulated

increases methylation

ISO

Methapyrilene results in increased methylation of CDON intron

NCBI chr 8:42,032,921...42,119,451
Ensembl chr 8:42,033,042...42,119,345

G

cerebellar degeneration-related protein 2-like

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDR2L exon

NCBI chr10:101,123,777...101,137,634
Ensembl chr10:101,123,777...101,137,634

G

chromatin licensing and DNA replication factor 1

increases expression

EXP

Methapyrilene results in increased expression of CDT1 mRNA

NCBI chr19:67,529,249...67,534,195
Ensembl chr19:67,529,201...67,534,194

G

caudal type homeo box 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CDX2 exon

NCBI chr12:12,762,769...12,769,246
Ensembl chr12:12,762,904...12,769,246

G

CEA cell adhesion molecule 1

decreases expression

EXP

Methapyrilene results in decreased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

CCAAT/enhancer binding protein delta

decreases expression

EXP

Methapyrilene results in decreased expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

CCAAT/enhancer binding protein epsilon

decreases methylation

ISO

Methapyrilene results in decreased methylation of CEBPE exon

NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476

G

CCAAT/enhancer binding protein gamma

decreases expression

EXP

Methapyrilene results in decreased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

CECR2, histone acetyl-lysine reader

increases methylation

ISO

Methapyrilene results in increased methylation of CECR2 intron

NCBI chr 4:155,562,576...155,670,253
Ensembl chr 4:155,562,727...155,666,741

G

chymotrypsin like elastase 2A

increases methylation

ISO

Methapyrilene results in increased methylation of CELA2A exon

NCBI chr 5:159,409,900...159,420,282
Ensembl chr 5:159,409,899...159,426,208

G

CUGBP, Elav-like family member 1

decreases expression

EXP

Methapyrilene results in decreased expression of CELF1 mRNA

NCBI chr 3:97,380,407...97,455,253
Ensembl chr 3:97,380,424...97,452,791

G

CUGBP, Elav-like family member 4

affects methylation

ISO

Methapyrilene affects the methylation of CELF4 intron

NCBI chr18:17,061,284...17,339,747
Ensembl chr18:17,061,293...17,339,571

G

CUGBP, Elav-like family member 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of CELF5 intron

NCBI chr 7:8,876,551...8,901,078
Ensembl chr 7:8,876,564...8,901,069

G

cadherin, EGF LAG seven-pass G-type receptor 1

increases methylation

ISO

Methapyrilene results in increased methylation of CELSR1 intron

NCBI chr 7:118,867,450...119,004,859
Ensembl chr 7:118,867,450...119,004,856

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases methylation

ISO

Methapyrilene results in increased methylation of CELSR3 intron

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:118,409,136...118,436,847

G

cell migration inducing hyaluronidase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CEMIP intron

NCBI chr 1:147,316,052...147,471,552
Ensembl chr 1:147,316,052...147,471,768

G

centromere protein P

increases methylation

ISO

Methapyrilene results in increased methylation of CENPP intron

NCBI chr17:15,220,521...15,395,741
Ensembl chr17:15,220,291...15,395,739

G

centrosomal protein 104

increases methylation

ISO

Methapyrilene results in increased methylation of CEP104 intron

NCBI chr 5:169,817,383...169,849,681
Ensembl chr 5:169,817,182...169,852,695

G

centrosomal protein 131

decreases methylation

ISO

Methapyrilene results in decreased methylation of CEP131 intron

NCBI chr10:105,844,433...105,868,811
Ensembl chr10:105,844,433...105,868,797

G

centrosomal protein 152

decreases expression

EXP

Methapyrilene results in decreased expression of CEP152 mRNA

NCBI chr 3:133,243,979...133,332,271
Ensembl chr 3:133,263,174...133,331,655
Ensembl chr 3:133,263,174...133,331,655

G

centrosomal protein 85-like

increases methylation

ISO

Methapyrilene results in increased methylation of CEP85L intron

NCBI chr20:33,111,114...33,282,182
Ensembl chr20:33,115,438...33,282,238

G

ceramide kinase

increases methylation

ISO

Methapyrilene results in increased methylation of CERK intron

NCBI chr 7:119,105,674...119,149,885
Ensembl chr 7:119,105,674...119,148,570

G

ceramide synthase 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of CERS4 intron

NCBI chr12:7,649,610...7,688,066
Ensembl chr12:7,649,610...7,688,070

G

ceramide synthase 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of CERS5 intron

NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786

G

carboxylesterase 2H

increases expression

EXP

Methapyrilene results in increased expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

carboxylesterase 3a

decreases methylation

ISO

Methapyrilene results in decreased methylation of CES3 exon

NCBI chr19:49,902,312...49,910,484

G

carboxylesterase 5A

affects methylation
increases methylation

ISO

Methapyrilene affects the methylation of CES5A intron
Methapyrilene results in increased methylation of CES5A exon

NCBI chr19:11,198,829...11,504,887
Ensembl chr19:11,419,189...11,504,887

G

cilia and flagella associated protein 100

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP100 intron

NCBI chr 4:124,471,913...124,495,990
Ensembl chr 4:124,472,023...124,495,799

G

cilia and flagella associated protein 221

decreases methylation

ISO

Methapyrilene results in decreased methylation of CFAP221 exon

NCBI chr13:33,599,322...33,669,721
Ensembl chr13:33,598,895...33,669,549

G

cilia and flagella associated protein 46

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP46 intron

NCBI chr 1:203,832,818...203,912,389
Ensembl chr 1:203,832,522...203,912,587

G

cilia and flagella associated protein 52

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP52 exon

NCBI chr10:53,112,692...53,153,844
Ensembl chr10:53,112,693...53,153,844

G

cilia and flagella associated protein 61

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP61 exon

NCBI chr 3:153,807,672...154,086,591
Ensembl chr 3:153,807,735...154,086,590

G

cilia and flagella associated protein 70

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP70 intron

NCBI chr15:3,901,544...3,967,224
Ensembl chr15:3,901,610...3,967,220

G

cilia and flagella associated protein 74

increases methylation

ISO

Methapyrilene results in increased methylation of CFAP74 intron; Methapyrilene results in increased methylation of CFAP74 promoter

NCBI chr 5:171,252,907...171,328,351
Ensembl chr 5:171,262,113...171,328,349

G

cilia and flagella associated protein 99

decreases methylation

ISO

Methapyrilene results in decreased methylation of CFAP99 intron

NCBI chr14:80,625,864...80,692,753
Ensembl chr14:80,653,704...80,692,725

G

cofilin 2

decreases expression

EXP

Methapyrilene results in decreased expression of CFL2 mRNA

NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888

G

cingulin-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of CGNL1 mRNA

NCBI chr 8:81,154,169...81,305,598
Ensembl chr 8:81,140,091...81,305,747

G

cell growth regulator with EF hand domain 1

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of CGREF1 mRNA
Methapyrilene results in increased methylation of CGREF1 intron

PMID:15890375 PMID:30157460

NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:31,151,795...31,163,800

G

cell growth regulator with ring finger domain 1

increases expression

EXP

Methapyrilene results in increased expression of CGRRF1 mRNA

NCBI chr15:22,560,902...22,588,815
Ensembl chr15:22,568,332...22,588,811

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

EXP

Methapyrilene results in decreased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

chromosome alignment maintaining phosphoprotein 1

decreases expression

EXP

Methapyrilene results in decreased expression of CHAMP1 mRNA

NCBI chr16:82,436,172...82,447,144
Ensembl chr16:82,434,823...82,458,984

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases methylation

ISO

Methapyrilene results in increased methylation of CHCHD6 intron

NCBI chr 4:123,360,729...123,581,429
Ensembl chr 4:123,349,187...123,581,421

G

chromodomain helicase DNA binding protein 1-like

increases methylation

ISO

Methapyrilene results in increased methylation of CHD1L intron

NCBI chr 2:187,819,869...187,906,359
Ensembl chr 2:187,811,954...187,890,477

G

chromodomain helicase DNA binding protein 5

increases methylation

ISO

Methapyrilene results in increased methylation of CHD5 intron

NCBI chr 5:168,130,851...168,181,705
Ensembl chr 5:168,130,575...168,179,441

G

checkpoint kinase 1

increases expression

EXP

Methapyrilene results in increased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

cysteine-rich hydrophobic domain 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CHIC1 intron

NCBI chr X:72,427,851...72,471,924
Ensembl chr X:72,427,851...72,471,924

G

choline kinase alpha

increases expression

EXP

Methapyrilene results in increased expression of CHKA mRNA

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752

G

charged multivesicular body protein 1A

decreases methylation

ISO

Methapyrilene results in decreased methylation of CHMP1A intron

NCBI chr19:68,146,672...68,154,952
Ensembl chr19:68,146,672...68,154,952

G

charged multivesicular body protein 1B

decreases expression

EXP

Methapyrilene results in decreased expression of CHMP1B mRNA

NCBI chr18:63,010,270...63,012,800
Ensembl chr18:63,010,251...63,011,415

G

charged multivesicular body protein 2A

decreases expression

EXP

Methapyrilene results in decreased expression of CHMP2A mRNA

NCBI chr 1:82,731,212...82,735,088
Ensembl chr 1:82,732,231...82,738,613

G

chimerin 2

affects methylation

ISO

Methapyrilene affects the methylation of CHN2 intron

NCBI chr 4:84,478,989...84,738,068
Ensembl chr 4:84,704,862...84,738,068

G

cholinergic receptor nicotinic alpha 2 subunit

decreases methylation

ISO

Methapyrilene results in decreased methylation of CHRNA2 3' UTR

NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144

G

cholinergic receptor nicotinic beta 3 subunit

decreases methylation

ISO

Methapyrilene results in decreased methylation of CHRNB3 intron

NCBI chr16:71,411,847...71,454,225
Ensembl chr16:71,417,039...71,454,225

G

carbohydrate sulfotransferase 11

increases methylation

ISO

Methapyrilene results in increased methylation of CHST11 intron

NCBI chr 7:22,412,121...22,630,577
Ensembl chr 7:22,415,686...22,630,441

G

carbohydrate sulfotransferase 8

increases methylation

ISO

Methapyrilene results in increased methylation of CHST8 intron

NCBI chr 1:96,431,144...96,572,880
Ensembl chr 1:96,431,145...96,572,880

G

calcium and integrin binding family member 2

increases methylation

ISO

Methapyrilene results in increased methylation of CIB2 exon

NCBI chr 8:63,826,410...63,843,301
Ensembl chr 8:63,826,411...63,843,277

G

calcium and integrin binding family member 4

increases methylation

ISO

Methapyrilene results in increased methylation of CIB4 intron

NCBI chr 6:31,560,105...31,623,403
Ensembl chr 6:31,562,489...31,623,464

G

CIMAP1 family member D

increases methylation

ISO

Methapyrilene results in increased methylation of CIMAP1D promoter

NCBI chr 7:10,700,067...10,715,742
Ensembl chr 7:10,700,510...10,715,738

G

ciliary microtubule inner protein 2C

decreases methylation

ISO

Methapyrilene results in decreased methylation of CIMIP2C intron

NCBI chr 6:31,625,187...31,643,500
Ensembl chr 6:31,625,188...31,643,629

G

cold inducible RNA binding protein

decreases expression

EXP

Methapyrilene results in decreased expression of CIRBP mRNA

NCBI chr 7:10,184,515...10,189,623

G

ciliated left-right organizer protein containing ZP-N domains

decreases methylation

ISO

Methapyrilene results in decreased methylation of CIROZ promoter

NCBI chr 5:164,358,333...164,393,758
Ensembl chr 5:164,358,306...164,388,485

G

citron rho-interacting serine/threonine kinase

increases methylation

ISO

Methapyrilene results in increased methylation of CIT intron

NCBI chr12:46,263,881...46,425,642
Ensembl chr12:46,266,369...46,424,656

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

EXP

Methapyrilene results in decreased expression of CITED2 mRNA

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

cytoskeleton associated protein 2

decreases methylation
increases expression

ISO
EXP

Methapyrilene results in decreased methylation of CKAP2 exon
Methapyrilene results in increased expression of CKAP2 mRNA

PMID:30157460 PMID:30467583

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:76,542,104...76,567,352

G

cytoskeleton-associated protein 4

decreases expression

EXP

Methapyrilene results in decreased expression of CKAP4 mRNA

NCBI chr 7:21,118,527...21,126,624
Ensembl chr 7:21,118,085...21,126,624

G

cytoskeleton associated protein 5

increases expression

EXP

Methapyrilene results in increased expression of CKAP5 mRNA

NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:97,947,031...98,049,049

G

CDC28 protein kinase regulatory subunit 2

increases expression

EXP

Methapyrilene results in increased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519

G

chloride channel CLIC-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of CLCC1 mRNA

NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:198,984,495...199,015,014

G

chloride voltage-gated channel 3

decreases expression

EXP

Methapyrilene results in decreased expression of CLCN3 mRNA

NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984

G

chloride voltage-gated channel 4

decreases expression

EXP

Methapyrilene results in decreased expression of CLCN4 mRNA

PMID:16393664 PMID:30467583

NCBI chr X:27,290,769...27,356,967
Ensembl chr X:27,290,868...27,356,939

G

chloride voltage-gated channel Kb

decreases methylation

ISO

Methapyrilene results in decreased methylation of CLCNKB intron

NCBI chr 5:158,993,073...159,005,618
Ensembl chr 5:158,993,074...159,004,900

G

claudin 1

decreases expression

EXP

Methapyrilene results in decreased expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 2

decreases expression

EXP

Methapyrilene results in decreased expression of CLDN2 mRNA

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377

G

claudin 4

increases methylation

ISO

Methapyrilene results in increased methylation of CLDN4 promoter

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

C-type lectin domain containing 11A

increases methylation

ISO

Methapyrilene results in increased methylation of CLEC11A polyA tail

NCBI chr 1:103,938,029...103,941,170
Ensembl chr 1:103,935,185...103,946,784

G

C-type lectin domain family 1, member B

increases expression

EXP

Methapyrilene results in increased expression of CLEC1B mRNA

NCBI chr 4:164,533,987...164,542,320
Ensembl chr 4:164,534,055...164,542,867

G

C-type lectin domain family 4, member F

increases methylation

ISO

Methapyrilene results in increased methylation of CLEC4F intron

NCBI chr 4:117,686,686...117,696,407
Ensembl chr 4:117,686,686...117,696,438

G

CAP-GLY domain containing linker protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of CLIP1 mRNA

NCBI chr12:38,571,533...38,678,779
Ensembl chr12:38,571,834...38,678,779

G

CDC-like kinase 1

increases expression

EXP

Methapyrilene results in increased expression of CLK1 mRNA

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

CDC-like kinase 3

affects methylation

ISO

Methapyrilene affects the methylation of CLK3 intron

NCBI chr 8:67,048,121...67,063,192
Ensembl chr 8:67,048,123...67,062,881

G

calmin

increases methylation

ISO

Methapyrilene results in increased methylation of CLMN intron

NCBI chr 6:129,470,613...129,572,079
Ensembl chr 6:129,478,149...129,572,027

G

CLN5, intracellular trafficking protein

decreases expression

EXP

Methapyrilene results in decreased expression of CLN5 mRNA

NCBI chr15:86,308,286...86,321,679
Ensembl chr 2:67,620,667...67,622,952
Ensembl chr15:67,620,667...67,622,952

G

CLN6, transmembrane ER protein

increases methylation

ISO

Methapyrilene results in increased methylation of CLN6 intron

NCBI chr 8:72,198,773...72,213,777
Ensembl chr 8:72,198,712...72,213,776

G

cleavage factor polyribonucleotide kinase subunit 1

increases expression

EXP

Methapyrilene results in increased expression of CLP1 mRNA

NCBI chr 3:90,213,461...90,217,165
Ensembl chr 3:90,213,465...90,217,538

G

CLPTM1 regulator of GABA type A receptor forward trafficking

affects methylation

ISO

Methapyrilene affects the methylation of CLPTM1 intron

NCBI chr 1:88,417,447...88,449,047
Ensembl chr 1:88,417,447...88,449,446

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

decreases expression

EXP

Methapyrilene results in decreased expression of CLPX mRNA

NCBI chr 8:74,700,602...74,740,244
Ensembl chr 8:74,700,662...74,744,762

G

clarin 2

increases methylation

ISO

Methapyrilene results in increased methylation of CLRN2 intron

NCBI chr14:69,868,556...69,878,850
Ensembl chr14:69,868,556...69,878,850

G

calsyntenin 2

increases methylation

ISO

Methapyrilene results in increased methylation of CLSTN2 exon

NCBI chr 8:106,899,894...107,516,402
Ensembl chr 8:106,899,894...107,040,053

G

collectrin, amino acid transport regulator

decreases methylation

ISO

Methapyrilene results in decreased methylation of CLTRN intron

NCBI chr X:33,993,825...34,027,124
Ensembl chr X:33,993,825...34,027,181

G

carboxymethylenebutenolidase homolog

decreases expression

EXP

Methapyrilene results in decreased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

c-Maf-inducing protein

affects methylation

ISO

Methapyrilene affects the methylation of CMIP intron

NCBI chr19:62,213,402...62,419,443
Ensembl chr19:62,213,365...62,417,500

G

cytidine/uridine monophosphate kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of CMPK2 intron

NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:48,802,321...48,813,652

G

cyclic nucleotide binding domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of CNBD1 intron

NCBI chr 5:37,030,954...37,403,996
Ensembl chr 5:37,030,362...37,403,752

G

carnosine dipeptidase 1

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of CNDP1 intron
Methapyrilene results in decreased expression of CNDP1 mRNA

PMID:30157460 PMID:30467583

NCBI chr18:80,254,499...80,305,845
Ensembl chr18:80,255,784...80,282,643

G

carnosine dipeptidase 2

decreases expression

EXP

Methapyrilene results in decreased expression of CNDP2 mRNA

NCBI chr18:80,314,799...80,331,900
Ensembl chr18:80,314,801...80,331,900

G

cyclic nucleotide gated channel subunit alpha 4

increases methylation

ISO

Methapyrilene results in increased methylation of CNGA4 intron

NCBI chr 1:169,134,332...169,168,317
Ensembl chr 1:169,164,206...169,168,224

G

cornichon family AMPA receptor auxiliary protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of CNIH3 intron

NCBI chr13:95,548,440...95,739,500
Ensembl chr13:95,598,998...95,772,064

G

cyclin and CBS domain divalent metal cation transport mediator 3

increases methylation

ISO

Methapyrilene results in increased methylation of CNNM3 exon

NCBI chr 9:46,251,252...46,266,613
Ensembl chr 9:46,251,265...46,266,613

G

CCR4-NOT transcription complex, subunit 1

decreases expression

EXP

Methapyrilene results in decreased expression of CNOT1 mRNA

NCBI chr19:9,261,290...9,352,636
Ensembl chr19:9,261,294...9,352,636

G

CCR4-NOT transcription complex, subunit 3

increases methylation

ISO

Methapyrilene results in increased methylation of CNOT3 exon

NCBI chr 1:74,471,284...74,487,527
Ensembl chr 1:74,470,566...74,487,527

G

CCR4-NOT transcription complex, subunit 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of CNOT6 intron

NCBI chr10:34,479,892...34,532,166
Ensembl chr10:34,481,938...34,524,416

G

CCR4-NOT transcription complex, subunit 6-like

decreases expression

EXP

Methapyrilene results in decreased expression of CNOT6L mRNA

NCBI chr14:13,714,475...13,806,481
Ensembl chr14:13,714,475...13,806,481

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression

EXP

Methapyrilene results in decreased expression of CNP mRNA

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

canopy FGF signaling regulator 1

increases methylation

ISO

Methapyrilene results in increased methylation of CNPY1 intron

NCBI chr 4:7,870,403...7,925,266
Ensembl chr 4:7,869,829...7,925,266

G

cannabinoid receptor 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CNR2 intron

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

ciliary neurotrophic factor receptor

increases methylation

ISO

Methapyrilene results in increased methylation of CNTFR intron

NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:61,619,326...61,645,795

G

centlein

decreases methylation

ISO

Methapyrilene results in decreased methylation of CNTLN intron

NCBI chr 5:104,340,801...104,622,491
Ensembl chr 5:104,342,173...104,630,976

G

contactin 1

affects methylation

ISO

Methapyrilene affects the methylation of CNTN1 intron

NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391

G

contactin 4

affects methylation

ISO

Methapyrilene affects the methylation of CNTN4 intron

NCBI chr 4:140,180,696...141,177,771
Ensembl chr 4:140,596,284...141,177,766

G

contactin 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of CNTN5 intron

NCBI chr 8:15,017,424...16,249,418
Ensembl chr 8:15,018,927...15,969,060

G

cytochrome C oxidase assembly factor 5

decreases expression

EXP

Methapyrilene results in decreased expression of COA5 mRNA

NCBI chr 9:47,147,267...47,160,724
Ensembl chr 9:47,147,267...47,160,672

G

Coenzyme A synthase

decreases expression

EXP

Methapyrilene results in decreased expression of COASY mRNA

NCBI chr10:86,514,850...86,519,130
Ensembl chr10:86,514,874...86,519,130

G

cordon-bleu WH2 repeat protein-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of COBLL1 mRNA

NCBI chr 3:70,161,369...70,324,844
Ensembl chr 3:70,161,372...70,323,460

G

component of oligomeric golgi complex 7

decreases expression

EXP

Methapyrilene results in decreased expression of COG7 mRNA

NCBI chr 1:185,921,053...185,980,711
Ensembl chr 1:185,889,348...185,983,421

G

component of oligomeric golgi complex 8

increases methylation

ISO

Methapyrilene results in increased methylation of COG8 exon

NCBI chr19:51,861,376...51,872,126
Ensembl chr19:51,861,376...51,872,129

G

collagen type XI alpha 2 chain

increases methylation

ISO

Methapyrilene results in increased methylation of COL11A2 intron

NCBI chr20:4,788,829...4,818,492
Ensembl chr20:4,788,829...4,817,648

G

collagen type XIII alpha 1 chain

affects methylation

ISO

Methapyrilene affects the methylation of COL13A1 intron

NCBI chr20:30,326,744...30,466,800
Ensembl chr20:30,326,744...30,466,800

G

collagen type XVI alpha 1 chain

increases methylation

ISO

Methapyrilene results in increased methylation of COL16A1 5' UTR

NCBI chr 5:147,672,559...147,727,007
Ensembl chr 5:147,672,601...147,727,011

G

collagen type XVII alpha 1 chain

decreases methylation

ISO

Methapyrilene results in decreased methylation of COL17A1 exon

NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:256,472,648...256,518,851

G

collagen type XVIII alpha 1 chain

decreases methylation
increases methylation

ISO

Methapyrilene results in decreased methylation of COL18A1 intron
Methapyrilene results in increased methylation of COL18A1 promoter

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collagen type I alpha 2 chain

increases expression

EXP

Methapyrilene results in increased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type XX alpha 1 chain

decreases methylation

ISO

Methapyrilene results in decreased methylation of COL20A1 intron

NCBI chr 3:188,477,663...188,512,326
Ensembl chr 3:188,465,648...188,511,078

G

collagen type XXII alpha 1 chain

increases methylation

ISO

Methapyrilene results in increased methylation of COL22A1 intron

NCBI chr 7:105,619,776...105,857,246
Ensembl chr 7:105,619,757...105,856,960

G

collagen type XXIII alpha 1 chain

affects methylation

ISO

Methapyrilene affects the methylation of COL23A1 intron

NCBI chr10:36,050,327...36,337,279
Ensembl chr10:36,050,259...36,337,897

G

collagen type II alpha 1 chain

affects methylation

ISO

Methapyrilene affects the methylation of COL2A1 exon

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

collagen type IV alpha 1 chain

increases expression

EXP

Methapyrilene results in increased expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

collagen type IV alpha 2 chain

decreases methylation

ISO

Methapyrilene results in decreased methylation of COL4A2 intron

NCBI chr16:84,749,672...84,885,520
Ensembl chr16:84,749,672...84,885,520

G

collagen type IV alpha 3 chain

decreases methylation

ISO

Methapyrilene results in decreased methylation of COL4A3 intron

NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:91,323,990...91,453,077

G

collagen type IV alpha 5 chain

affects methylation

ISO

Methapyrilene affects the methylation of COL4A5 intron

NCBI chr X:109,907,251...110,111,214
Ensembl chr X:109,907,346...110,111,214

G

collagen type IV alpha 6 chain

decreases methylation

ISO

Methapyrilene results in decreased methylation of COL4A6 intron

NCBI chr X:109,554,945...109,905,987
Ensembl chr X:109,552,651...109,905,944

G

collagen type V alpha 1 chain

affects methylation

ISO

Methapyrilene affects the methylation of COL5A1 intron

NCBI chr 3:31,606,475...31,755,097
Ensembl chr 3:31,606,486...31,753,020

G

collagen type V alpha 2 chain

increases expression

ISO

Methapyrilene results in increased expression of COL5A2 mRNA

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

collagen type VIII alpha 2 chain

increases methylation

ISO

Methapyrilene results in increased methylation of COL8A2 exon; Methapyrilene results in increased methylation of COL8A2 intron

NCBI chr 5:143,870,754...143,897,372
Ensembl chr 5:143,870,742...143,897,884

G

collagen type IX alpha 2 chain

increases methylation

ISO

Methapyrilene results in increased methylation of COL9A2 exon

NCBI chr 5:139,892,798...139,910,131
Ensembl chr 5:139,892,798...139,909,855

G

collagen type IX alpha 3 chain

decreases methylation
increases methylation

ISO

Methapyrilene results in decreased methylation of COL9A3 intron
Methapyrilene results in increased methylation of COL9A3 exon

NCBI chr 3:188,089,337...188,112,034
Ensembl chr 3:188,089,403...188,112,270

G

collagen beta(1-O)galactosyltransferase 1

increases methylation

ISO

Methapyrilene results in increased methylation of COLGALT1 intron

NCBI chr16:18,353,779...18,366,087
Ensembl chr16:18,353,570...18,366,086

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases methylation

ISO

Methapyrilene results in increased methylation of COLQ exon; Methapyrilene results in increased methylation of COLQ intron

NCBI chr16:6,738,251...6,830,492
Ensembl chr16:6,738,251...6,793,501

G

COMM domain containing 5

decreases expression

EXP

Methapyrilene results in decreased expression of COMMD5 mRNA

NCBI chr 7:110,502,492...110,503,916
Ensembl chr 7:110,479,403...110,505,897

G

catechol-O-methyltransferase

decreases methylation

ISO

Methapyrilene results in decreased methylation of COMT intron

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COPI coat complex subunit beta 1

decreases expression

EXP

Methapyrilene results in decreased expression of COPB1 mRNA

NCBI chr 1:177,838,751...177,876,688
Ensembl chr 1:177,838,752...177,872,840

G

COPI coat complex subunit gamma 1

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of COPG1 intron
Methapyrilene results in decreased expression of COPG1 mRNA

PMID:30157460 PMID:30467583

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

COP9 signalosome subunit 7A

decreases expression

EXP

Methapyrilene results in decreased expression of COPS7A mRNA

NCBI chr 4:159,452,878...159,478,878
Ensembl chr 4:159,452,897...159,460,315

G

coenzyme Q7, hydroxylase

increases methylation

ISO

Methapyrilene results in increased methylation of COQ7 intron

NCBI chr 1:182,270,570...182,285,959
Ensembl chr 1:182,269,399...182,285,508

G

coenzyme Q8A

decreases expression

EXP

Methapyrilene results in decreased expression of ADCK3 mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

corin, serine peptidase

increases methylation

ISO

Methapyrilene results in increased methylation of CORIN intron

NCBI chr14:36,034,613...36,264,671
Ensembl chr14:36,034,993...36,264,649

G

coronin 2A

increases methylation

ISO

Methapyrilene results in increased methylation of CORO2A intron

NCBI chr 5:65,623,820...65,677,483
Ensembl chr 5:65,623,823...65,654,602

G

coronin 2B

increases methylation

ISO

Methapyrilene results in increased methylation of CORO2B intron

NCBI chr 8:71,802,329...71,912,739
Ensembl chr 8:71,802,329...71,912,739

G

coronin 7

increases methylation

ISO

Methapyrilene results in increased methylation of CORO7 intron

NCBI chr10:11,386,683...11,447,422
Ensembl chr10:11,391,613...11,447,866

G

ceruloplasmin

increases expression

ISO

Methapyrilene results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

carboxypeptidase A2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CPA2 exon

NCBI chr 4:60,125,297...60,151,066
Ensembl chr 4:60,118,682...60,183,448

G

centrosome assembly and centriole elongation protein

increases methylation

ISO

Methapyrilene results in increased methylation of CPAP intron

NCBI chr15:34,742,838...34,806,020
Ensembl chr15:34,742,838...34,802,421

G

carboxypeptidase D

decreases expression

EXP

Methapyrilene results in decreased expression of CPD mRNA

NCBI chr10:62,121,681...62,185,638
Ensembl chr10:62,121,679...62,185,638

G

carboxypeptidase N subunit 1

decreases expression

EXP

Methapyrilene results in decreased expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

copine 2

increases methylation

ISO

Methapyrilene results in increased methylation of CPNE2 intron

NCBI chr19:10,440,245...10,477,783
Ensembl chr19:10,434,647...10,477,783

G

copine 3

decreases expression

EXP

Methapyrilene results in decreased expression of CPNE3 mRNA

NCBI chr 5:37,811,566...37,860,840
Ensembl chr 5:37,811,566...37,861,062

G

copine 4

increases methylation

EXP

Methapyrilene results in increased methylation of CPNE4 gene

NCBI chr 8:114,056,152...114,531,855
Ensembl chr 8:113,993,703...114,531,855

G

copine 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of CPNE5 exon; Methapyrilene results in decreased methylation of CPNE5 intron

NCBI chr20:7,208,389...7,290,959
Ensembl chr20:7,208,389...7,292,064

G

copine 8

decreases expression

EXP

Methapyrilene results in decreased expression of CPNE8 mRNA

NCBI chr 7:123,494,864...123,669,060
Ensembl chr 7:123,494,865...123,669,060

G

coproporphyrinogen oxidase

decreases expression

EXP

Methapyrilene results in decreased expression of CPOX mRNA

NCBI chr11:55,405,778...55,415,761
Ensembl chr11:55,405,784...55,415,761

G

calcineurin-like phosphoesterase domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of CPPED1 mRNA

NCBI chr10:4,135,601...4,328,039
Ensembl chr10:4,208,463...4,231,065

G

carboxypeptidase Q

increases expression

EXP

Methapyrilene results in increased expression of PGCP mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

carbamoyl-phosphate synthase 1

decreases expression

EXP

Methapyrilene results in decreased expression of CPS1 mRNA

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

carnitine palmitoyltransferase 1A

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of CPT1A mRNA
Methapyrilene results in increased methylation of CPT1A intron

PMID:15120968 PMID:30157460 PMID:30467583

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 1c

decreases methylation

ISO

Methapyrilene results in decreased methylation of CPT1C exon

NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:104,579,298...104,593,763

G

carboxypeptidase Z

increases methylation

ISO

Methapyrilene results in increased methylation of CPZ intron

NCBI chr14:79,448,242...79,471,557
Ensembl chr14:79,448,139...79,471,556

G

complement C3b/C4b receptor 1 like

increases expression

EXP

Methapyrilene results in increased expression of CR1L mRNA

NCBI chr13:109,138,132...109,189,068
Ensembl chr13:109,103,235...109,188,869

G

cellular retinoic acid binding protein 1

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of CRABP1 intron
Methapyrilene results in decreased methylation of CRABP1 promoter

NCBI chr 8:64,047,431...64,055,469
Ensembl chr 8:64,047,060...64,055,470

G

capping protein inhibiting regulator of actin dynamics

increases methylation

EXP

Methapyrilene results in increased methylation of CRACD gene

NCBI chr14:31,638,328...31,874,391
Ensembl chr14:31,638,328...31,683,987

G

calcium release activated channel regulator 2A

increases methylation

ISO

Methapyrilene results in increased methylation of CRACR2A intron

NCBI chr 4:162,094,247...162,207,926
Ensembl chr 4:162,110,929...162,221,529

G

crumbs cell polarity complex component 1

affects methylation

ISO

Methapyrilene affects the methylation of CRB1 intron

NCBI chr13:53,352,932...53,540,019
Ensembl chr13:53,352,932...53,540,019

G

crumbs cell polarity complex component 3

decreases expression

EXP

Methapyrilene results in decreased expression of CRB3 mRNA

NCBI chr 9:1,985,504...1,990,855
Ensembl chr 9:1,983,619...1,993,486

G

cAMP responsive element binding protein 3-like 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of CREB3L3 intron

NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:9,273,338...9,281,778

G

cAMP responsive element binding protein 5

affects methylation

ISO

Methapyrilene affects the methylation of CREB5 intron

NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793

G

CREB binding protein

decreases expression

EXP

Methapyrilene results in decreased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

CREB/ATF bZIP transcription factor

decreases expression

EXP

Methapyrilene results in decreased expression of CREBZF mRNA

NCBI chr 1:153,829,544...153,836,073
Ensembl chr 1:153,829,448...153,845,122

G

cysteine rich transmembrane BMP regulator 1

increases methylation

ISO

Methapyrilene results in increased methylation of CRIM1 exon

NCBI chr 6:22,447,983...22,622,459
Ensembl chr 6:22,449,948...22,622,416

G

collapsin response mediator protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of CRMP1 intron

NCBI chr14:77,734,675...77,780,916
Ensembl chr14:77,734,675...77,780,916

G

carnitine O-octanoyltransferase

decreases expression

EXP

Methapyrilene results in decreased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064

G

cartilage acidic protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of CRTAC1 intron

NCBI chr 1:251,040,963...251,182,920
Ensembl chr 1:251,028,143...251,182,689

G

cytotoxic and regulatory T cell molecule

increases methylation

ISO

Methapyrilene results in increased methylation of CRTAM intron

NCBI chr 8:50,237,210...50,274,472
Ensembl chr 8:50,237,210...50,274,472

G

CREB regulated transcription coactivator 1

increases methylation

ISO

Methapyrilene results in increased methylation of CRTC1 3' UTR; Methapyrilene results in increased methylation of CRTC1 intron

NCBI chr16:19,022,171...19,080,880
Ensembl chr16:19,022,005...19,080,880

G

CREB regulated transcription coactivator 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of CRTC3 intron

NCBI chr 1:143,962,038...144,064,324
Ensembl chr 1:143,962,038...144,064,288

G

cone-rod homeobox

increases methylation

ISO

Methapyrilene results in increased methylation of CRX 3' UTR

NCBI chr 1:85,667,971...85,681,852
Ensembl chr 1:85,667,971...85,681,852

G

crystallin beta-gamma domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of AIM1L exon

NCBI chr 5:151,570,154...151,602,164
Ensembl chr 5:151,570,540...151,602,163

G

crystallin, lambda 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CRYL1 intron

NCBI chr15:35,542,628...35,661,563
Ensembl chr15:35,542,628...35,661,563

G

cysteine sulfinic acid decarboxylase

decreases expression

EXP

Methapyrilene results in decreased expression of CSAD mRNA

NCBI chr 7:135,187,175...135,216,495
Ensembl chr 7:135,187,175...135,215,581

G

colony stimulating factor 2 receptor subunit beta

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of CSF2RB exon; Methapyrilene results in increased methylation of CSF2RB promoter
Methapyrilene results in decreased methylation of CSF2RB intron

NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:111,757,405...111,784,654

G

CUB and Sushi multiple domains 1

affects methylation

ISO

Methapyrilene affects the methylation of CSMD1 intron

NCBI chr16:78,920,549...80,520,710
Ensembl chr16:78,921,002...80,519,944

G

CUB and Sushi multiple domains 2

increases methylation

ISO

Methapyrilene results in increased methylation of CSMD2 intron

NCBI chr 5:145,626,823...146,196,815
Ensembl chr 5:145,626,845...146,196,812

G

CUB and Sushi multiple domains 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of CSMD3 intron

NCBI chr 7:80,637,341...81,956,469
Ensembl chr 7:80,638,143...81,956,162

G

casein kinase 1, gamma 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CSNK1G2 intron

NCBI chr 7:9,727,430...9,746,341
Ensembl chr 7:9,727,431...9,745,741

G

casein kinase 2 alpha 1

increases methylation

ISO

Methapyrilene results in increased methylation of CSNK2A1 intron

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

centrosome and spindle pole associated protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CSPP1 intron

NCBI chr 5:13,860,072...13,975,299
Ensembl chr 5:13,860,072...13,975,321

G

cysteine and serine rich nuclear protein 1

increases expression

EXP

Methapyrilene results in increased expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:128,582,365...128,588,469

G

cysteine and glycine-rich protein 2

increases expression

EXP

Methapyrilene results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cystatin 12

increases expression

EXP

Methapyrilene results in increased expression of CST12 mRNA

NCBI chr 3:156,688,155...156,692,052
Ensembl chr 3:156,688,049...156,692,052

G

cystatin C

increases expression

EXP

Methapyrilene results in increased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

cystatin B

increases expression

EXP

Methapyrilene results in increased expression of CSTB mRNA

PMID:15890375 PMID:30467583

NCBI chr20:10,245,157...10,247,199
Ensembl chr20:10,245,158...10,247,199

G

cleavage stimulation factor subunit 2, tau variant

decreases expression

EXP

Methapyrilene results in decreased expression of CSTF2T mRNA

NCBI chr 1:238,366,042...238,369,608
Ensembl chr 1:238,365,912...238,369,749

G

C-terminal binding protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTBP2 intron

NCBI chr 1:197,208,536...197,348,802
Ensembl chr 1:197,212,133...197,254,261

G

CCCTC-binding factor like 1

increases methylation

ISO

Methapyrilene results in increased methylation of CTCFL intron

NCBI chr 3:182,286,637...182,309,272
Ensembl chr 3:182,286,637...182,309,272

G

CTD small phosphatase 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTDSP2 intron

NCBI chr 7:64,690,737...64,710,639
Ensembl chr 7:64,690,490...64,710,639

G

CTD small phosphatase like 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTDSPL2 intron

NCBI chr 3:129,365,709...129,424,232
Ensembl chr 3:129,368,938...129,424,232

G

cardiotrophin 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTF1 intron

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

cystathionine gamma-lyase

decreases expression

EXP

Methapyrilene results in decreased expression of CTH mRNA

PMID:16393664 PMID:30467583

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cap binding complex dependent translation initiation factor

decreases methylation
increases methylation

ISO

Methapyrilene results in decreased methylation of CTIF intron
Methapyrilene results in increased methylation of CTIF 3' UTR

NCBI chr18:71,331,222...71,602,493
Ensembl chr18:71,307,314...71,602,492

G

catenin alpha-like 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTNNAL1 intron

NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:76,309,546...76,364,637

G

cystinosin, lysosomal cystine transporter

decreases methylation

ISO

Methapyrilene results in decreased methylation of CTNS intron

NCBI chr10:58,300,069...58,315,725
Ensembl chr10:58,299,967...58,321,661

G

CTP synthase 2

increases methylation

ISO

Methapyrilene results in increased methylation of CTPS2 intron

NCBI chr X:35,277,658...35,418,505
Ensembl chr X:35,277,658...35,418,505

G

cathepsin C

decreases expression

EXP

Methapyrilene results in decreased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

cathepsin D

increases expression

EXP

Methapyrilene results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cut-like homeobox 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CUX1 intron

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:25,743,733...26,062,497

G

cut-like homeobox 2

increases methylation

ISO

Methapyrilene results in increased methylation of CUX2 intron

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:40,149,292...40,366,528

G

CXADR, Ig-like cell adhesion molecule

increases expression

EXP

Methapyrilene results in increased expression of CXADR mRNA

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988

G

C-X-C motif chemokine ligand 1

decreases expression

EXP

Methapyrilene results in decreased expression of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of CXCL10 mRNA
Methapyrilene results in decreased expression of CXCL10 protein

PMID:15890375 PMID:25051504

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of CXCL12 mRNA
Methapyrilene results in increased methylation of CXCL12 intron

PMID:28935588 PMID:30157460

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 9

increases expression

EXP

Methapyrilene results in increased expression of CXCL9 mRNA

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

cytochrome b5 type A

decreases expression

EXP

Methapyrilene results in decreased expression of CYB5A mRNA

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytoplasmic FMR1 interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of CYFIP1 intron

NCBI chr 1:115,842,754...115,935,163
Ensembl chr 1:115,846,661...115,951,292

G

cytoplasmic FMR1 interacting protein 2

affects methylation

ISO

Methapyrilene affects the methylation of CYFIP2 intron

NCBI chr10:31,122,653...31,242,440
Ensembl chr10:31,122,653...31,242,440

G

CYLD lysine 63 deubiquitinase

increases expression

EXP

Methapyrilene results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 20, subfamily a, polypeptide 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP20A1 mRNA

NCBI chr 9:69,249,841...69,299,146
Ensembl chr 9:69,249,844...69,299,291

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of CYP27B1 exon

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity

EXP

Methapyrilene results in decreased activity of CYP2C11 protein

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily c, polypeptide 13

increases expression

EXP

Methapyrilene results in increased expression of CYP2C13 mRNA

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily c, polypeptide 7

decreases expression

EXP

Methapyrilene results in decreased expression of CYP2C7 mRNA

NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388

G

cytochrome P450, family 2, subfamily d, polypeptide 2

increases expression

EXP

Methapyrilene results in increased expression of CYP2D2 mRNA

NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

EXP

Methapyrilene results in decreased expression of CYP2D4 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

ISO
EXP

Methapyrilene results in decreased expression of CYP2E1 mRNA

PMID:28935588 PMID:30467583

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

decreases expression

EXP

Methapyrilene results in decreased expression of CYP2F4 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily j, polypeptide 3

decreases expression

EXP

Methapyrilene results in decreased expression of CYP2J3 mRNA

NCBI chr 5:116,335,755...116,360,677
Ensembl chr 5:116,335,755...116,360,499

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases expression

EXP

Methapyrilene results in decreased expression of CYP2J4 mRNA

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 18

increases expression

EXP

Methapyrilene results in increased expression of CYP3A18 mRNA

NCBI chr12:13,994,312...14,044,185
Ensembl chr12:13,994,311...14,045,788

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression

EXP

Methapyrilene results in decreased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytochrome P450, family 4, subfamily v, polypeptide 3

decreases expression

EXP

Methapyrilene results in decreased expression of CYP4V3 mRNA

NCBI chr16:53,650,978...53,675,916
Ensembl chr16:53,650,569...53,676,746

G

cytochrome P450, family 51

increases expression

EXP

Methapyrilene results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 7 subfamily B member 1

increases methylation

ISO

Methapyrilene results in increased methylation of CYP7B1 intron

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

EXP

Methapyrilene results in decreased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

CYFIP related Rac1 interactor A

increases methylation

ISO

Methapyrilene results in increased methylation of CYRIA intron

NCBI chr 6:40,774,165...40,883,005
Ensembl chr 6:40,774,171...40,881,860

G

CYFIP related Rac1 interactor B

increases methylation

ISO

Methapyrilene results in increased methylation of CYRIB promoter

NCBI chr 7:97,524,941...97,649,846
Ensembl chr 7:97,523,121...97,649,853

G

cytohesin 4

increases methylation

ISO

Methapyrilene results in increased methylation of CYTH4 intron

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:112,032,775...112,057,204

G

dishevelled associated activator of morphogenesis 1

decreases expression

EXP

Methapyrilene results in decreased expression of DAAM1 mRNA

NCBI chr 6:96,125,521...96,286,049
Ensembl chr 6:96,125,621...96,286,049

G

dishevelled associated activator of morphogenesis 2

increases methylation

ISO

Methapyrilene results in increased methylation of DAAM2 intron

NCBI chr 9:18,926,620...19,044,672
Ensembl chr 9:18,926,623...19,044,671

G

DAB adaptor protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of DAB1 intron

NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584

G

DAB2 interacting protein

increases methylation

ISO

Methapyrilene results in increased methylation of DAB2IP intron

NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730

G

dishevelled-binding antagonist of beta-catenin 2

increases methylation
affects methylation

ISO

Methapyrilene results in increased methylation of DACT2 exon
Methapyrilene affects the methylation of DACT2 intron

NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:63,854,182...63,864,255

G

dystroglycan 1

increases methylation
decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of DAG1 promoter
Methapyrilene results in decreased methylation of DAG1 exon
Methapyrilene results in decreased expression of DAG1 mRNA

PMID:30157460 PMID:30467583

NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:117,769,517...117,782,199

G

D-amino-acid oxidase

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of DAO mRNA
Methapyrilene results in increased methylation of DAO intron

PMID:16393664 PMID:30157460 PMID:30467583

NCBI chr12:48,252,900...48,275,964
Ensembl chr12:48,252,902...48,273,300

G

death associated protein kinase 1

decreases expression

EXP

Methapyrilene results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

death-associated protein kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of DAPK2 intron

NCBI chr 8:75,601,621...75,720,619
Ensembl chr 8:75,601,634...75,720,617

G

death-associated protein kinase 3

decreases expression

EXP

Methapyrilene results in decreased expression of DAPK3 mRNA

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

aspartyl-tRNA synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of DARS1 mRNA

NCBI chr13:42,410,351...42,465,467
Ensembl chr13:42,379,162...42,465,467

G

dynein assembly factor with WD repeats 1

increases methylation

ISO

Methapyrilene results in increased methylation of DAW1 intron

NCBI chr 9:91,883,656...91,920,733
Ensembl chr 9:91,881,067...91,921,349

G

diazepam binding inhibitor

increases expression

EXP

Methapyrilene results in increased expression of DBI mRNA

NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450

G

drebrin 1

increases methylation

ISO

Methapyrilene results in increased methylation of DBN1 exon

NCBI chr17:9,155,729...9,170,121
Ensembl chr17:9,155,787...9,170,122

G

D-box binding PAR bZIP transcription factor

increases methylation

ISO

Methapyrilene results in increased methylation of DBP intron

NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205

G

dihydrolipoamide branched chain transacylase E2

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of DBT mRNA
Methapyrilene results in increased methylation of DBT intron

PMID:30157460 PMID:30467583

NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:207,166,652...207,195,525

G

DDB1 and CUL4 associated factor 11

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of DCAF11 mRNA
Methapyrilene results in decreased methylation of DCAF11 exon

PMID:30157460 PMID:30467583

NCBI chr15:33,015,370...33,027,407
Ensembl chr15:33,016,762...33,027,672

G

DDB1 and CUL4 associated factor 4

increases methylation

ISO

Methapyrilene results in increased methylation of DCAF4 intron

NCBI chr 6:108,885,970...108,912,116
Ensembl chr 6:108,885,932...108,912,110

G

dephospho-CoA kinase domain containing

decreases methylation

ISO

Methapyrilene results in decreased methylation of DCAKD intron

NCBI chr10:88,457,829...88,489,011
Ensembl chr10:88,457,829...88,480,118

G

doublecortin domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of DCDC2 intron

NCBI chr17:40,274,009...40,459,757
Ensembl chr17:40,274,009...40,458,790

G

dachsous cadherin-related 2

increases methylation

ISO

Methapyrilene results in increased methylation of DCHS2 intron

NCBI chr 2:170,775,818...170,983,844
Ensembl chr 2:170,776,682...170,981,770

G

doublecortin-like kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of DCLK2 intron

NCBI chr 2:174,506,660...174,636,353
Ensembl chr 2:174,506,660...174,636,192

G

decapping enzyme, scavenger

decreases methylation

ISO

Methapyrilene results in decreased methylation of DCPS intron

NCBI chr 8:41,729,507...41,782,222
Ensembl chr 8:41,724,563...41,782,222

G

dynactin subunit 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of DCTN4 intron

NCBI chr18:56,251,187...56,279,844
Ensembl chr18:56,252,780...56,279,842

G

defective in cullin neddylation 1 domain containing 4

decreases expression

EXP

Methapyrilene results in decreased expression of DCUN1D4 mRNA

NCBI chr14:35,006,792...35,087,285
Ensembl chr14:35,006,792...35,088,520

G

dimethylarginine dimethylaminohydrolase 1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of DDAH1 mRNA
Methapyrilene results in decreased expression of DDAH1 mRNA

PMID:15890375 PMID:30467583

NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:237,327,766...237,460,626

G

DNA damage inducible 1 homolog 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of DDI2 intron

NCBI chr 5:159,272,625...159,318,365
Ensembl chr 5:159,272,625...159,318,310

G

DNA-damage inducible transcript 3

increases expression

EXP
ISO

Methapyrilene results in increased expression of DDIT3 mRNA

PMID:15120968 PMID:17450226 PMID:28935588 PMID:30467583

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of DDIT4 mRNA
Methapyrilene results in decreased expression of DDIT4 mRNA

PMID:22484513 PMID:30467583

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DNA-damage-inducible transcript 4-like

increases expression

EXP

Methapyrilene results in increased expression of DDIT4L mRNA

NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:228,801,705...228,806,225

G

DEAD/H-box helicase 11

decreases methylation

ISO

Methapyrilene results in decreased methylation of DDX11 intron

NCBI chr 9:113,204,886...113,309,692
Ensembl chr 9:113,276,985...113,316,152

G

DEAD-box helicase 17

decreases expression

EXP

Methapyrilene results in decreased expression of DDX17 mRNA

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747

G

DEAD-box helicase 20

increases methylation

ISO

Methapyrilene results in increased methylation of DDX20 intron

NCBI chr 2:195,847,105...195,859,989
Ensembl chr 2:195,847,105...195,855,461

G

DExD-box helicase 21

increases expression

EXP

Methapyrilene results in increased expression of DDX21 mRNA

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

DExD-box helicase 39A

increases expression

EXP

Methapyrilene results in increased expression of DDX39A mRNA

PMID:18619722 PMID:28935588

NCBI chr19:41,323,465...41,331,413
Ensembl chr19:41,322,836...41,332,306

G

DEAD-box helicase 41

increases methylation

ISO

Methapyrilene results in increased methylation of DDX41 intron

NCBI chr17:9,108,030...9,113,562
Ensembl chr17:9,108,074...9,113,561

G

DEAD-box helicase 46

decreases expression

EXP

Methapyrilene results in decreased expression of DDX46 mRNA

NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,947,237...8,990,247

G

2,4-dienoyl-CoA reductase 1

decreases expression

EXP

Methapyrilene results in decreased expression of DECR1 mRNA

PMID:16393664 PMID:30467583

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

2,4-dienoyl-CoA reductase 2

decreases expression

EXP

Methapyrilene results in decreased expression of DECR2 mRNA

NCBI chr10:15,609,389...15,617,779
Ensembl chr10:15,611,092...15,617,397

G

differentially expressed in FDCP 8 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of DEF8 3' UTR

NCBI chr19:68,383,293...68,404,133
Ensembl chr19:68,383,349...68,404,125

G

DENN domain containing 1A

increases methylation

ISO

Methapyrilene results in increased methylation of DENND1A 3' UTR

NCBI chr 3:41,974,502...42,461,816
Ensembl chr 3:41,974,502...42,461,886

G

DENN domain containing 2B

decreases methylation

ISO

Methapyrilene results in decreased methylation of DENND2B intron

NCBI chr 1:172,978,895...173,129,623
Ensembl chr 1:172,978,895...173,129,810

G

DEP domain containing 1

decreases expression

ISO

Methapyrilene results in decreased expression of DEPDC1 mRNA

NCBI chr 2:251,343,250...251,376,709
Ensembl chr 2:251,343,281...251,376,709

G

DEP domain containing 5, GATOR1 subcomplex subunit

increases methylation

ISO

Methapyrilene results in increased methylation of DEPDC5 intron

NCBI chr14:81,956,777...82,087,392
Ensembl chr14:81,956,777...82,087,246

G

DEP domain containing 7

increases expression

EXP

Methapyrilene results in increased expression of DEPDC7 mRNA

NCBI chr 3:111,554,701...111,575,979
Ensembl chr 3:111,554,706...111,575,979

G

DEP domain containing MTOR-interacting protein

increases methylation

ISO

Methapyrilene results in increased methylation of DEPTOR intron

NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:88,404,620...88,574,041

G

derlin 1

decreases expression

EXP

Methapyrilene results in decreased expression of DERL1 mRNA

NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678

G

DET1 partner of COP1 E3 ubiquitin ligase

increases methylation

ISO

Methapyrilene results in increased methylation of DET1 exon

NCBI chr 1:142,159,120...142,175,366
Ensembl chr 1:142,127,876...142,175,336

G

DiGeorge syndrome critical region gene 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of DGCR2 intron

NCBI chr11:96,598,247...96,648,791
Ensembl chr11:96,597,197...96,648,786

G

diacylglycerol kinase, gamma

increases methylation

ISO

Methapyrilene results in increased methylation of DGKG intron

NCBI chr11:91,888,957...92,083,715
Ensembl chr11:91,888,782...92,082,105

G

diacylglycerol kinase, iota

increases methylation

ISO

Methapyrilene results in increased methylation of DGKI intron

NCBI chr 4:66,377,897...66,839,790
Ensembl chr 4:66,387,126...66,990,832

G

diacylglycerol kinase zeta

decreases methylation

ISO

Methapyrilene results in decreased methylation of DGKZ intron

NCBI chr 3:98,359,804...98,401,847
Ensembl chr 3:98,359,804...98,401,951

G

dehydrodolichyl diphosphate synthase subunit

decreases expression

EXP

Methapyrilene results in decreased expression of DHDDS mRNA

NCBI chr 5:151,482,139...151,508,248
Ensembl chr 5:151,481,429...151,508,129

G

dihydrofolate reductase

increases methylation

ISO

Methapyrilene results in increased methylation of DHFR intron

NCBI chr 2:25,320,895...25,346,004

G

dehydrogenase/reductase 4

decreases expression

EXP

Methapyrilene results in decreased expression of DHRS4 mRNA

NCBI chr15:32,924,482...32,948,103
Ensembl chr15:32,936,522...32,948,101

G

dehydrogenase E1 and transketolase domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of DHTKD1 mRNA

NCBI chr17:77,242,512...77,316,074
Ensembl chr17:77,264,514...77,316,071

G

DExH-box helicase 30

decreases methylation

ISO

Methapyrilene results in decreased methylation of DHX30 intron

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592

G

DEAH-box helicase 32 (putative)

decreases expression

EXP

Methapyrilene results in decreased expression of DHX32 mRNA

NCBI chr 1:197,954,503...198,013,779
Ensembl chr 1:197,954,503...198,007,489

G

DEAH-box helicase 35

increases methylation

ISO

Methapyrilene results in increased methylation of DHX35 intron

NCBI chr 3:167,869,971...167,927,300
Ensembl chr 3:167,870,055...167,927,300

G

DEAH-box helicase 36

decreases expression

EXP

Methapyrilene results in decreased expression of DHX36 mRNA

NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:149,006,089...149,044,191

G

DEAH-box helicase 37

increases methylation

ISO

Methapyrilene results in increased methylation of DHX37 intron

NCBI chr12:36,856,119...36,876,245
Ensembl chr12:36,849,701...36,876,240

G

DEAH-box helicase 8

increases methylation

ISO

Methapyrilene results in increased methylation of DHX8 intron

NCBI chr10:87,167,861...87,204,426
Ensembl chr10:87,168,062...87,205,875

G

diaphanous-related formin 2

affects methylation

ISO

Methapyrilene affects the methylation of DIAPH2 intron

NCBI chr X:96,700,535...97,528,080
Ensembl chr X:96,700,726...97,528,080

G

diaphanous-related formin 3

decreases expression

EXP

Methapyrilene results in decreased expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:68,951,989...69,421,552

G

death inducer-obliterator 1

increases methylation

ISO

Methapyrilene results in increased methylation of DIDO1 intron

NCBI chr 3:188,150,100...188,203,445
Ensembl chr 3:188,150,100...188,194,823

G

disco-interacting protein 2 homolog C

increases methylation

ISO

Methapyrilene results in increased methylation of DIP2C intron

NCBI chr17:65,338,711...65,724,111
Ensembl chr17:65,338,711...65,723,344

G

DIRAS family GTPase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of DIRAS1 intron

NCBI chr 7:9,338,660...9,343,524
Ensembl chr 7:9,327,335...9,347,881

G

dispatched RND transporter family member 3

increases methylation

ISO

Methapyrilene results in increased methylation of DISP3 intron

NCBI chr 5:163,955,160...164,003,980
Ensembl chr 5:163,955,160...164,003,950

G

dyskerin pseudouridine synthase 1

increases expression

EXP

Methapyrilene results in increased expression of DKC1 mRNA

NCBI chr  X:157,751,651...157,757,796
Ensembl chr  Y:380,743...385,405
Ensembl chr  X:380,743...385,405

G

dihydrolipoamide S-acetyltransferase

decreases expression

EXP

Methapyrilene results in decreased expression of DLAT protein

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

discs large MAGUK scaffold protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of DLG1 mRNA

NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797

G

discs large MAGUK scaffold protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of DLG2 intron

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

discs large MAGUK scaffold protein 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of DLG5 intron

NCBI chr15:125,287...237,334
Ensembl chr15:125,290...237,332

G

DLG associated protein 1

affects methylation

ISO

Methapyrilene affects the methylation of DLGAP1 intron

NCBI chr 9:117,304,144...118,173,463
Ensembl chr 9:117,614,061...118,173,463

G

DLG associated protein 2

affects methylation

ISO

Methapyrilene affects the methylation of DLGAP2 intron

NCBI chr16:81,489,059...82,198,693
Ensembl chr16:81,494,649...82,198,684

G

DLG associated protein 4

affects methylation

ISO

Methapyrilene affects the methylation of DLGAP4 intron

NCBI chr 3:165,584,271...165,731,868
Ensembl chr 3:165,584,360...165,730,604

G

DLG associated protein 5

increases methylation

ISO

Methapyrilene results in increased methylation of DLGAP5 intron

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

delta like non-canonical Notch ligand 1

increases methylation

ISO

Methapyrilene results in increased methylation of DLK1 polyA tail

NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529

G

delta like canonical Notch ligand 4

increases methylation

ISO

Methapyrilene results in increased methylation of DLL4 3' UTR

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

deleted in malignant brain tumors 1

increases methylation

ISO

Methapyrilene results in increased methylation of DMBT1 intron

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

dimethylglycine dehydrogenase

increases expression

EXP

Methapyrilene results in increased expression of DMGDH protein

NCBI chr 2:26,647,540...26,722,496
Ensembl chr 2:26,647,565...26,723,071

G

Dmx-like 2

decreases expression

EXP

Methapyrilene results in decreased expression of DMXL2 mRNA

NCBI chr 8:63,637,314...63,803,911
Ensembl chr 8:63,637,314...63,781,116

G

dynein axonemal assembly factor 9

decreases methylation

ISO

Methapyrilene results in decreased methylation of DNAAF9 intron

NCBI chr 3:138,370,971...138,505,711
Ensembl chr 3:138,372,531...138,505,695

G

dynein, axonemal, heavy chain 1

affects methylation
decreases methylation

ISO

Methapyrilene affects the methylation of DNAH1 intron
Methapyrilene results in decreased methylation of DNAH1 exon

NCBI chr16:6,462,419...6,523,545
Ensembl chr16:6,462,419...6,524,760

G

dynein, axonemal, heavy chain 10

decreases methylation

ISO

Methapyrilene results in decreased methylation of DNAH10 intron

NCBI chr12:37,484,444...37,607,810
Ensembl chr12:37,472,813...37,640,860

G

dynein axonemal heavy chain 14

increases methylation

ISO

Methapyrilene results in increased methylation of DNAH14 intron

NCBI chr13:95,853,735...96,070,327
Ensembl chr13:95,854,534...96,070,330

G

dynein, axonemal, heavy chain 2

increases methylation

ISO

Methapyrilene results in increased methylation of DNAH2 intron

NCBI chr10:54,641,450...54,766,502
Ensembl chr10:54,641,450...54,766,026

G

dynein, axonemal, heavy chain 8

affects methylation

ISO

Methapyrilene affects the methylation of DNAH8 intron

NCBI chr20:8,694,371...8,948,849
Ensembl chr20:8,694,398...8,948,849

G

dynein, axonemal, heavy chain 9

decreases methylation

ISO

Methapyrilene results in decreased methylation of DNAH9 intron

NCBI chr10:50,996,796...51,363,977
Ensembl chr10:50,996,796...51,363,963

G

dynein, axonemal, intermediate chain 2

increases methylation

ISO

Methapyrilene results in increased methylation of DNAI2 intron

NCBI chr10:100,259,022...100,292,427
Ensembl chr10:100,258,994...100,292,426

G

dynein axonemal intermediate chain 7

increases methylation

ISO

Methapyrilene results in increased methylation of DNAI7 intron

NCBI chr 4:179,874,338...179,910,716
Ensembl chr 4:179,873,522...179,910,780

G

DnaJ heat shock protein family (Hsp40) member A1

increases methylation

ISO

Methapyrilene results in increased methylation of DNAJA1 intron

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member B13

increases methylation

ISO

Methapyrilene results in increased methylation of DNAJB13 intron

NCBI chr 1:164,260,716...164,275,172
Ensembl chr 1:164,260,724...164,275,093

G

DnaJ heat shock protein family (Hsp40) member B6

increases methylation

ISO

Methapyrilene results in increased methylation of DNAJB6 intron

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member C14

decreases expression

EXP

Methapyrilene results in decreased expression of DNAJC14 mRNA

NCBI chr 7:1,818,360...1,831,642
Ensembl chr 7:1,820,247...1,831,658

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

EXP

Methapyrilene results in increased expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

DnaJ heat shock protein family (Hsp40) member C5

decreases methylation

ISO

Methapyrilene results in decreased methylation of DNAJC5 intron

NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:188,999,470...189,034,089

G

DnaJ heat shock protein family (Hsp40) member C7

increases methylation

ISO

Methapyrilene results in increased methylation of DNAJC7 intron

NCBI chr10:86,018,977...86,055,419
Ensembl chr10:86,018,961...86,055,489

G

dynamin 3

increases methylation

ISO

Methapyrilene results in increased methylation of DNM3 intron

NCBI chr13:76,892,381...77,371,346
Ensembl chr13:76,892,171...77,371,350

G

dynamin binding protein

decreases expression

EXP

Methapyrilene results in decreased expression of DNMBP mRNA

NCBI chr 1:252,685,406...252,778,642
Ensembl chr 1:252,685,406...252,778,688

G

double C2 domain alpha

decreases methylation

ISO

Methapyrilene results in decreased methylation of DOC2A exon

NCBI chr 1:190,887,306...190,893,057
Ensembl chr 1:190,888,214...190,893,384

G

double C2 domain beta

increases methylation

ISO

Methapyrilene results in increased methylation of DOC2B intron

NCBI chr10:61,126,295...61,151,533
Ensembl chr10:61,126,295...61,151,533

G

dedicator of cytokinesis 10

increases methylation

ISO

Methapyrilene results in increased methylation of DOCK10 intron

NCBI chr 9:89,291,936...89,549,871
Ensembl chr 9:89,291,800...89,549,973

G

dedicator of cytokinesis 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of DOCK4 intron

NCBI chr 6:63,240,050...63,629,772
Ensembl chr 6:63,240,136...63,629,772

G

dedicator of cytokinesis 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of DOCK5 exon

NCBI chr15:46,155,124...46,334,127
Ensembl chr15:46,155,125...46,334,042

G

dedicator of cytokinesis 7

decreases expression

EXP

Methapyrilene results in decreased expression of DOCK7 mRNA

NCBI chr 5:118,714,863...118,898,362
Ensembl chr 5:118,714,863...118,898,335

G

dedicator of cytokinesis 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of DOCK8 intron

NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:232,075,588...232,268,833

G

dedicator of cytokinesis 9

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of DOCK9 intron
Methapyrilene results in decreased expression of DOCK9 mRNA

PMID:30157460 PMID:30467583

NCBI chr15:105,018,341...105,289,799
Ensembl chr15:105,024,912...105,289,799

G

dolichol kinase

decreases expression

EXP

Methapyrilene results in decreased expression of DOLK mRNA

NCBI chr 3:33,955,642...33,957,680
Ensembl chr 3:33,954,308...33,958,365

G

DNA replication fork stabilization factor DONSON

decreases methylation

ISO

Methapyrilene results in decreased methylation of DONSON intron

NCBI chr11:44,405,794...44,419,099
Ensembl chr11:44,405,804...44,418,791

G

DOP1 leucine zipper like protein B

decreases methylation

ISO

Methapyrilene results in decreased methylation of DOP1B intron

NCBI chr11:46,494,058...46,595,601
Ensembl chr11:46,494,058...46,595,601

G

deleted in primary ciliary dyskinesia

decreases methylation

ISO

Methapyrilene results in decreased methylation of DPCD 3' UTR

NCBI chr 1:254,357,755...254,375,918
Ensembl chr 1:254,357,778...254,375,918

G

double PHD fingers 1

affects methylation

ISO

Methapyrilene affects the methylation of DPF1 intron

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:93,726,970...93,743,425

G

double PHD fingers 3

affects methylation

ISO

Methapyrilene affects the methylation of DPF3 intron

NCBI chr 6:108,577,792...108,856,724
Ensembl chr 6:108,577,183...108,856,798

G

diphthamine biosynthesis 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of DPH6 intron

NCBI chr 3:121,761,495...121,891,727
Ensembl chr 3:121,676,141...121,891,658

G

dipeptidyl peptidase like 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of DPP6 intron

NCBI chr 4:8,323,220...9,242,694
Ensembl chr 4:8,324,843...9,242,209

G

dipeptidylpeptidase 8

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of DPP8 mRNA
Methapyrilene results in decreased methylation of DPP8 intron

PMID:30157460 PMID:30467583

NCBI chr 8:74,445,815...74,501,017
Ensembl chr 8:74,445,835...74,501,017

G

dipeptidyl peptidase 9

increases methylation

ISO

Methapyrilene results in increased methylation of DPP9 intron

NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715

G

dermatopontin

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of DPT mRNA
Methapyrilene results in increased methylation of DPT intron

PMID:30157460 PMID:30467583

NCBI chr13:79,656,341...79,684,759
Ensembl chr13:79,655,985...79,684,758

G

dpy-19 like C-mannosyltransferase 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of DPY19L3 intron

NCBI chr 1:97,487,206...97,554,232
Ensembl chr 1:97,487,206...97,554,232

G

dihydropyrimidine dehydrogenase

decreases expression

EXP

Methapyrilene results in decreased expression of DPYD mRNA

PMID:15890375 PMID:30467583

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

dihydropyrimidinase-like 2

increases methylation

ISO

Methapyrilene results in increased methylation of DPYSL2 intron

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

dihydropyrimidinase-like 3

increases methylation

ISO

Methapyrilene results in increased methylation of DPYSL3 intron

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

DNA damage regulated autophagy modulator 2

decreases expression

EXP

Methapyrilene results in decreased expression of DRAM2 mRNA

NCBI chr 2:196,724,052...196,752,645
Ensembl chr 2:196,723,858...196,755,103

G

dorsal inhibitory axon guidance protein

increases methylation

ISO

Methapyrilene results in increased methylation of DRAXIN intron

NCBI chr 5:163,813,308...163,846,609
Ensembl chr 5:163,816,502...163,855,174

G

desmocollin 3

increases methylation

ISO

Methapyrilene results in increased methylation of DSC3 intron

NCBI chr18:11,654,833...11,688,871
Ensembl chr18:11,653,832...11,688,871

G

DS cell adhesion molecule

increases methylation

ISO

Methapyrilene results in increased methylation of DSCAM intron

NCBI chr11:49,391,385...49,976,861
Ensembl chr11:49,347,531...49,976,238

G

DS cell adhesion molecule-like 1

increases methylation

ISO

Methapyrilene results in increased methylation of DSCAML1 exon; Methapyrilene results in increased methylation of DSCAML1 intron

NCBI chr 8:54,637,054...54,954,042
Ensembl chr 8:54,636,932...54,954,040

G

desmoglein 2

decreases expression

EXP

Methapyrilene results in decreased expression of DSG2 mRNA

NCBI chr18:12,121,287...12,179,590
Ensembl chr18:12,121,181...12,179,590

G

dual serine/threonine and tyrosine protein kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of DSTYK 3' UTR

NCBI chr13:46,409,412...46,457,426
Ensembl chr13:46,409,412...46,457,424

G

D-aminoacyl-tRNA deacylase 2

increases methylation

ISO

Methapyrilene results in increased methylation of DTD2 intron

NCBI chr 6:75,185,496...75,191,774
Ensembl chr 6:75,156,201...75,191,774

G

dystrobrevin, alpha

decreases methylation

ISO

Methapyrilene results in decreased methylation of DTNA intron

NCBI chr18:14,862,801...15,218,993
Ensembl chr18:14,862,818...15,218,993

G

DTW domain containing 2

decreases expression

EXP

Methapyrilene results in decreased expression of DTWD2 mRNA

NCBI chr18:45,003,242...45,088,595
Ensembl chr18:45,003,644...45,088,419

G

deltex E3 ubiquitin ligase 3L

decreases expression

EXP

Methapyrilene results in decreased expression of DTX3L mRNA

NCBI chr11:78,320,225...78,329,837
Ensembl chr11:78,317,650...78,329,837

G

dual oxidase 1

increases expression

ISO

Methapyrilene results in increased expression of DUOX1 mRNA

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:129,714,149...129,749,187

G

dual specificity phosphatase 13B

increases expression

ISO

Methapyrilene results in increased expression of DUSP13B mRNA

NCBI chr15:2,616,761...2,624,434
Ensembl chr15:2,609,049...2,624,887

G

dual specificity phosphatase 22

affects methylation

ISO

Methapyrilene affects the methylation of DUSP22 intron

NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,989,637...34,039,895

G

dual specificity phosphatase 4

increases methylation

ISO

Methapyrilene results in increased methylation of DUSP4 intron

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:64,079,893...64,093,700

G

dual specificity phosphatase 5

increases methylation

ISO

Methapyrilene results in increased methylation of DUSP5 promoter

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 6

decreases expression
increases expression

EXP

Methapyrilene results in decreased expression of DUSP6 mRNA
Methapyrilene results in increased expression of DUSP6 mRNA

PMID:15890375 PMID:30467583

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

deoxyuridine triphosphatase

increases expression

EXP

Methapyrilene results in increased expression of DUT mRNA

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

DPY30 domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of DYDC2 promoter

NCBI chr16:16,962,273...16,976,034
Ensembl chr16:16,962,290...16,970,258

G

dymeclin

increases methylation

ISO

Methapyrilene results in increased methylation of DYM intron

NCBI chr18:70,879,835...71,176,006
Ensembl chr18:70,880,255...71,176,004

G

dynein cytoplasmic 1 heavy chain 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of DYNC1H1 intron

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

EXP

Methapyrilene results in decreased expression of DYNC1LI2 mRNA

NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107

G

dynein cytoplasmic 2 heavy chain 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of DYNC2H1 intron

NCBI chr 8:12,473,955...12,697,075
Ensembl chr 8:12,473,955...12,697,058

G

dynein 2 intermediate chain 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of DYNC2I2 intron

NCBI chr 3:33,703,882...33,719,960
Ensembl chr 3:33,703,882...33,719,960

G

dynein light chain LC8-type 1

increases expression

EXP

Methapyrilene results in increased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dynein light chain LC8-type 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of DYNLL2 promoter

NCBI chr10:73,264,260...73,283,042
Ensembl chr10:73,264,261...73,272,285

G

dual specificity tyrosine phosphorylation regulated kinase 2

decreases expression

EXP

Methapyrilene results in decreased expression of DYRK2 mRNA

NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:56,235,276...56,265,942

G

dysferlin

increases methylation

ISO

Methapyrilene results in increased methylation of DYSF intron

NCBI chr 4:118,048,460...118,248,273
Ensembl chr 4:118,047,989...118,248,273

G

double zinc ribbon and ankyrin repeat domains 1

increases methylation

ISO

Methapyrilene results in increased methylation of DZANK1 intron

NCBI chr 3:152,309,228...152,361,548
Ensembl chr 3:152,309,228...152,361,548

G

DAZ interacting zinc finger protein 1-like

increases methylation

ISO

Methapyrilene results in increased methylation of DZIP1L intron

NCBI chr 8:109,067,466...109,108,390
Ensembl chr 8:109,067,775...109,108,393

G

E2F transcription factor 4

increases methylation

ISO

Methapyrilene results in increased methylation of E2F4 exon

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834

G

glutamyl-tRNA synthetase 2, mitochondrial

decreases expression

EXP

Methapyrilene results in decreased expression of EARS2 mRNA

NCBI chr 1:186,025,740...186,057,165

G

estrogen receptor binding site associated antigen 9

decreases expression

EXP

Methapyrilene results in decreased expression of EBAG9 mRNA

NCBI chr 7:77,695,213...77,713,565
Ensembl chr 7:77,695,072...77,713,557

G

EBF transcription factor 3

increases methylation

ISO

Methapyrilene results in increased methylation of EBF3 intron

NCBI chr 1:201,426,446...201,544,444
Ensembl chr 1:201,426,450...201,544,305

G

endothelin converting enzyme 1

decreases expression

EXP

Methapyrilene results in decreased expression of ECE1 mRNA

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

enoyl-CoA hydratase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ECH1 mRNA

NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440

G

enoyl CoA hydratase domain containing 3

decreases expression

EXP

Methapyrilene results in decreased expression of ECHDC3 mRNA

NCBI chr17:76,980,112...77,002,934
Ensembl chr17:76,980,083...77,002,934

G

enoyl-CoA hydratase, short chain 1

increases expression

EXP

Methapyrilene results in increased expression of ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

enoyl-CoA delta isomerase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

enoyl-Coenzyme A delta isomerase 3

decreases expression

EXP

Methapyrilene results in decreased expression of ECI3 mRNA

NCBI chr17:30,127,425...30,149,249
Ensembl chr17:30,128,588...30,149,137

G

ectodysplasin-A receptor

increases methylation

ISO

Methapyrilene results in increased methylation of EDAR exon

NCBI chr20:27,130,934...27,209,672
Ensembl chr20:27,130,934...27,209,630

G

enhancer of mRNA decapping 3

decreases expression

EXP

Methapyrilene results in decreased expression of EDC3 mRNA

NCBI chr 8:67,002,032...67,047,563
Ensembl chr 8:67,002,014...67,047,559

G

ER degradation enhancing alpha-mannosidase like protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of EDEM1 mRNA

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

ER degradation enhancing alpha-mannosidase like protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of EDEM2 intron

NCBI chr 3:164,661,741...164,687,559
Ensembl chr 3:164,661,742...164,687,559

G

ER degradation enhancing alpha-mannosidase like protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of EDEM3 mRNA

NCBI chr13:66,403,022...66,470,496
Ensembl chr13:66,408,590...66,472,270

G

endothelial differentiation-related factor 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of EDF1 polyA tail

NCBI chr 3:28,764,906...28,779,499

G

EGF like repeats and discoidin domains 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of EDIL3 intron

NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379

G

embryonic ectoderm development

increases expression

EXP

Methapyrilene results in increased expression of EED mRNA

NCBI chr 1:153,280,419...153,307,537
Ensembl chr 1:153,280,422...153,307,500

G

eukaryotic translation elongation factor 1 alpha 2

increases methylation

ISO

Methapyrilene results in increased methylation of EEF1A2 intron

NCBI chr 3:188,643,455...188,652,633
Ensembl chr 3:188,643,458...188,677,712

G

eukaryotic translation elongation factor 1 gamma

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of EEF1G mRNA
Methapyrilene results in decreased expression of EEF1G protein

PMID:15890375 PMID:30467583

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

eukaryotic translation elongation factor 2

increases expression

EXP

Methapyrilene results in increased expression of EEF2 mRNA

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544

G

eukaryotic elongation factor-2 kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of EEF2K intron

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048

G

EF-hand calcium binding domain 6

affects methylation

ISO

Methapyrilene affects the methylation of EFCAB6 intron

NCBI chr 7:116,899,022...117,085,998
Ensembl chr 7:116,899,022...117,075,827

G

EF-hand domain family, member D1

decreases methylation

ISO

Methapyrilene results in decreased methylation of EFHD1 intron

NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798

G

ephrin A2

decreases methylation

ISO

Methapyrilene results in decreased methylation of EFNA2 intron

NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:10,167,091...10,177,719

G

EFR3 homolog A

decreases expression

EXP

Methapyrilene results in decreased expression of EFR3A mRNA

NCBI chr 7:99,441,764...99,522,454
Ensembl chr 7:99,441,767...99,522,454

G

EFR3 homolog B

increases methylation

ISO

Methapyrilene results in increased methylation of EFR3B intron

NCBI chr 6:32,664,593...32,740,417
Ensembl chr 6:32,666,945...32,740,417

G

EGF-like-domain, multiple 7

increases methylation

ISO

Methapyrilene results in increased methylation of EGFL7 intron

NCBI chr 3:29,802,481...29,814,966
Ensembl chr 3:29,802,690...29,814,951

G

epidermal growth factor receptor

decreases expression

EXP

Methapyrilene results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

EH domain binding protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of EHBP1 mRNA

NCBI chr14:100,294,585...100,581,764
Ensembl chr14:100,294,585...100,546,579

G

EH domain binding protein 1-like 1

increases methylation

ISO

Methapyrilene results in increased methylation of EHBP1L1 exon

NCBI chr 1:212,423,444...212,444,357
Ensembl chr 1:212,423,447...212,443,598

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

EXP

Methapyrilene results in decreased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

euchromatic histone lysine methyltransferase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of EHMT1 intron

NCBI chr 3:27,978,888...28,127,178
Ensembl chr 3:27,978,888...28,127,349

G

EP300 interacting inhibitor of differentiation 1

decreases expression

EXP

Methapyrilene results in decreased expression of EID1 mRNA

NCBI chr 3:133,376,389...133,378,108
Ensembl chr 3:133,370,474...133,378,434

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

EXP

Methapyrilene results in decreased expression of EIF1AX mRNA

NCBI chr X:39,307,320...39,322,023
Ensembl chr X:39,307,137...39,322,021

G

eukaryotic translation initiation factor 2-alpha kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of EIF2AK2 intron

NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases expression

EXP

Methapyrilene results in decreased expression of EIF2AK3 mRNA

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2B subunit gamma

increases methylation

ISO

Methapyrilene results in increased methylation of EIF2B3 intron

NCBI chr 5:135,728,764...135,795,276
Ensembl chr 5:135,728,959...135,799,914

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

EXP

Methapyrilene results in increased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 4E

increases expression

EXP

Methapyrilene results in increased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

EXP

Methapyrilene results in increased expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4E binding protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of EIF4EBP3 mRNA

NCBI chr18:28,540,324...28,542,070
Ensembl chr18:28,540,058...28,542,061

G

eukaryotic translation initiation factor 4 gamma, 3

decreases methylation
decreases expression

EXP

Methapyrilene results in decreased methylation of EIF4G3 gene
Methapyrilene results in decreased expression of EIF4G3 mRNA

PMID:26431795 PMID:30467583

NCBI chr 5:155,481,378...155,702,194
Ensembl chr 5:155,481,378...155,702,194

G

EARP complex and GARP complex interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of EIPR1 intron

NCBI chr 6:51,116,827...51,230,453
Ensembl chr 6:51,116,747...51,230,452

G

ELAV like RNA binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of ELAVL2 intron

NCBI chr 5:111,076,705...111,202,341
Ensembl chr 5:111,076,705...111,224,918

G

E74 like ETS transcription factor 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of ELF4 intron

NCBI chr X:132,465,290...132,508,175
Ensembl chr X:132,468,539...132,478,689

G

E74 like ETS transcription factor 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of ELF5 intron

NCBI chr 3:110,264,460...110,291,926
Ensembl chr 3:110,252,797...110,291,926

G

extracellular leucine-rich repeat and fibronectin type III domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of ELFN1 intron

NCBI chr12:19,773,911...19,839,375
Ensembl chr12:19,772,908...19,841,961

G

extracellular leucine-rich repeat and fibronectin type III domain containing 2

affects methylation

ISO

Methapyrilene affects the methylation of ELFN2 intron

NCBI chr 7:112,101,998...112,153,280
Ensembl chr 7:112,074,331...112,153,451

G

ETS transcription factor ELK4

decreases expression

EXP

Methapyrilene results in decreased expression of ELK4 mRNA

NCBI chr13:46,004,145...46,027,206
Ensembl chr13:46,004,182...46,027,199

G

elongation factor for RNA polymerase II

increases methylation

ISO

Methapyrilene results in increased methylation of ELL intron

NCBI chr16:18,877,751...18,925,449
Ensembl chr16:18,877,751...18,925,076

G

engulfment and cell motility 3

decreases expression

EXP

Methapyrilene results in decreased expression of ELMO3 mRNA

NCBI chr19:50,091,883...50,096,324
Ensembl chr19:50,091,924...50,096,338

G

elongation factor 1

increases methylation

ISO

Methapyrilene results in increased methylation of ELOF1 exon

NCBI chr 8:28,921,338...28,926,612
Ensembl chr 8:28,921,339...28,926,228

G

ELOVL fatty acid elongase 2

decreases expression

EXP

Methapyrilene results in decreased expression of ELOVL2 mRNA

NCBI chr17:23,750,350...23,790,601
Ensembl chr17:23,750,350...23,790,601

G

elongator acetyltransferase complex subunit 2

decreases expression

EXP

Methapyrilene results in decreased expression of ELP2 mRNA

NCBI chr18:16,160,686...16,196,307
Ensembl chr18:16,160,671...16,196,414

G

ER membrane protein complex subunit 10

increases methylation

ISO

Methapyrilene results in increased methylation of EMC10 promoter

NCBI chr 1:104,119,040...104,125,409
Ensembl chr 1:104,119,040...104,125,368

G

elastin microfibril interfacer 2

affects methylation

ISO

Methapyrilene affects the methylation of EMILIN2 intron

NCBI chr 9:118,607,312...118,667,087
Ensembl chr 9:118,606,891...118,666,957

G

EMAP like 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of EML4 intron

NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439

G

epithelial membrane protein 1

decreases expression

EXP

Methapyrilene results in decreased expression of EMP1 mRNA

NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365

G

ectodermal-neural cortex 1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of ENC1 mRNA
Methapyrilene results in decreased expression of ENC1 mRNA

PMID:22484513 PMID:30467583

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

endonuclease V

decreases methylation

ISO

Methapyrilene results in decreased methylation of ENDOV polyA tail

NCBI chr10:105,258,540...105,276,209
Ensembl chr10:105,258,593...105,276,209

G

endoglin

increases methylation

ISO

Methapyrilene results in increased methylation of ENG intron

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933

G

endo-beta-N-acetylglucosaminidase

increases methylation

ISO

Methapyrilene results in increased methylation of ENGASE 3' UTR

NCBI chr10:104,205,753...104,218,416
Ensembl chr10:104,205,752...104,218,411

G

glutamyl aminopeptidase

increases methylation

ISO

Methapyrilene results in increased methylation of ENPEP intron

NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of ENPP2 mRNA
Methapyrilene results in decreased methylation of ENPP2 intron

PMID:16393664 PMID:30157460

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

EXP

Methapyrilene results in decreased expression of ENPP3 mRNA

NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:22,382,964...22,454,314

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of ENPP7 intron

NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760

G

ectonucleoside triphosphate diphosphohydrolase 3

increases methylation

ISO

Methapyrilene results in increased methylation of ENTPD3 promoter

NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:129,124,709...129,156,252

G

endosomal transmembrane epsin interactor 1

increases methylation

ISO

Methapyrilene results in increased methylation of ENTREP1 intron

NCBI chr 1:231,018,987...231,073,474
Ensembl chr 1:231,018,987...231,102,708

G

E1A binding protein p400

increases methylation

ISO

Methapyrilene results in increased methylation of EP400 intron

NCBI chr12:51,551,665...51,658,635
Ensembl chr12:51,551,695...51,658,634

G

erythrocyte membrane protein band 4.1-like 1

increases methylation

ISO

Methapyrilene results in increased methylation of EPB41L1 intron

NCBI chr 3:165,389,295...165,512,821
Ensembl chr 3:165,389,293...165,510,498

G

erythrocyte membrane protein band 4.1 like 4B

increases methylation

ISO

Methapyrilene results in increased methylation of EPB41L4B intron

NCBI chr 5:76,486,886...76,647,752
Ensembl chr 5:76,486,902...76,647,752

G

erythrocyte membrane protein band 4.1 like 5

decreases expression

EXP

Methapyrilene results in decreased expression of EPB41L5 mRNA

NCBI chr13:33,221,705...33,321,400
Ensembl chr13:33,223,589...33,321,133

G

ectopic P-granules 5 autophagy tethering factor

increases methylation

ISO

Methapyrilene results in increased methylation of EPG5 intron

NCBI chr18:73,679,106...73,776,694
Ensembl chr18:73,679,116...73,776,677

G

Eph receptor A1

increases methylation

ISO

Methapyrilene results in increased methylation of EPHA1 exon

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

EPH receptor A10

decreases methylation

ISO

Methapyrilene results in decreased methylation of EPHA10 intron

NCBI chr 5:142,424,260...142,460,305
Ensembl chr 5:142,424,296...142,460,305

G

Eph receptor A2

increases expression

EXP

Methapyrilene results in increased expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234

G

Eph receptor A8

increases methylation

ISO

Methapyrilene results in increased methylation of EPHA8 intron

NCBI chr 5:154,449,566...154,476,966
Ensembl chr 5:154,449,566...154,476,966

G

Eph receptor B2

increases methylation

ISO

Methapyrilene results in increased methylation of EPHB2 intron

NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615

G

epoxide hydrolase 1

increases expression

EXP

Methapyrilene results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

epoxide hydrolase 2

decreases expression

EXP

Methapyrilene results in decreased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

epsin 2

increases methylation

ISO

Methapyrilene results in increased methylation of EPN2 intron

NCBI chr10:46,697,238...46,759,128
Ensembl chr10:46,697,238...46,759,092

G

epiplakin 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of EPPK1 exon

NCBI chr 7:109,697,607...109,718,468
Ensembl chr 7:109,697,607...109,718,468

G

glutamyl-prolyl-tRNA synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of EPRS1 mRNA

NCBI chr13:99,431,955...99,503,510
Ensembl chr13:99,433,130...99,503,509

G

epidermal growth factor receptor pathway substrate 15

decreases expression

EXP

Methapyrilene results in decreased expression of EPS15 mRNA

NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856

G

epidermal growth factor receptor pathway substrate 15-like 1

affects methylation

ISO

Methapyrilene affects the methylation of EPS15L1 intron

NCBI chr16:17,460,330...17,573,824
Ensembl chr16:17,460,465...17,535,703

G

EPS8 signaling adaptor L3

increases methylation

ISO

Methapyrilene results in increased methylation of EPS8L3 intron

NCBI chr 2:198,202,862...198,216,255
Ensembl chr 2:198,200,486...198,216,255

G

endoplasmic reticulum aminopeptidase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ERAP1 mRNA

NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:5,666,436...5,740,056

G

ELKS/RAB6-interacting/CAST family member 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of ERC1 intron

NCBI chr 4:154,435,936...154,727,987
Ensembl chr 4:154,435,944...154,727,987

G

ELKS/RAB6-interacting/CAST family member 2

increases methylation

ISO

Methapyrilene results in increased methylation of ERC2 intron

NCBI chr16:2,819,399...3,680,258
Ensembl chr16:2,819,512...3,680,258

G

ERCC excision repair 5, endonuclease

decreases methylation

ISO

Methapyrilene results in decreased methylation of ERCC5 intron

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:53,801,714...53,875,084

G

ETS transcription factor ERG

decreases methylation
increases methylation

ISO

Methapyrilene results in decreased methylation of ERG intron
Methapyrilene results in increased methylation of ERG 3' UTR

NCBI chr11:48,148,149...48,370,472
Ensembl chr11:48,148,153...48,370,688

G

ERI1 exoribonuclease family member 3

increases methylation

ISO

Methapyrilene results in increased methylation of ERI3 polyA tail

NCBI chr 5:136,252,691...136,379,832
Ensembl chr 5:136,252,683...136,379,815

G

ER lipid raft associated 1

decreases expression

EXP

Methapyrilene results in decreased expression of ERLIN1 mRNA

NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:252,870,356...252,905,947

G

ER lipid raft associated 2

decreases expression

EXP

Methapyrilene results in decreased expression of ERLIN2 mRNA

NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503

G

ERBB receptor feedback inhibitor 1

decreases expression

EXP

Methapyrilene results in decreased expression of ERRFI1 mRNA

NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432

G

espin

decreases methylation

ISO

Methapyrilene results in decreased methylation of ESPN intron

NCBI chr 5:167,909,271...167,943,168
Ensembl chr 5:167,909,271...167,942,984

G

estrogen receptor 1

affects methylation

ISO

Methapyrilene affects the methylation of ESR1 intron

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen-related receptor gamma

decreases methylation

ISO

Methapyrilene results in decreased methylation of ESRRG intron

NCBI chr13:101,699,043...102,316,877
Ensembl chr13:101,889,706...102,316,877

G

extended synaptotagmin 1

increases methylation

ISO

Methapyrilene results in increased methylation of ESYT1 intron

NCBI chr 7:1,513,381...1,530,836
Ensembl chr 7:1,513,381...1,530,732

G

electron transfer flavoprotein subunit alpha

increases methylation

ISO

Methapyrilene results in increased methylation of ETFA intron

NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:64,731,193...64,788,080

G

electron transfer flavoprotein subunit beta

increases expression

EXP

Methapyrilene results in increased expression of ETFB protein

NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659

G

electron transfer flavoprotein dehydrogenase

decreases expression

EXP

Methapyrilene results in decreased expression of ETFDH mRNA

NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:167,025,823...167,060,770

G

enhancer trap locus 4

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of KIAA1217 intron
Methapyrilene results in decreased expression of ETL4 mRNA

PMID:30157460 PMID:30467583

NCBI chr17:87,749,486...88,213,158
Ensembl chr17:87,403,819...88,213,158

G

ethanolamine kinase 1

decreases expression

EXP

Methapyrilene results in decreased expression of ETNK1 mRNA

NCBI chr 4:177,857,001...177,901,278
Ensembl chr 4:177,856,960...177,924,721

G

ETS proto-oncogene 2, transcription factor

decreases methylation

ISO

Methapyrilene results in decreased methylation of ETS2 promoter

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842

G

ETS variant transcription factor 6

affects methylation

ISO

Methapyrilene affects the methylation of ETV6 intron

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802

G

eva-1 homolog C

increases methylation

ISO

Methapyrilene results in increased methylation of EVA1C intron

NCBI chr11:43,575,613...43,649,677
Ensembl chr11:43,576,332...43,649,834

G

Enah/Vasp-like

increases methylation

ISO

Methapyrilene results in increased methylation of EVL polyA tail

NCBI chr 6:133,238,547...133,358,730
Ensembl chr 6:133,238,547...133,358,729

G

exocyst complex component 1

decreases expression

EXP

Methapyrilene results in decreased expression of EXOC1 mRNA

NCBI chr14:31,965,782...32,014,156
Ensembl chr14:31,965,782...32,014,127

G

exocyst complex component 2

decreases expression

EXP

Methapyrilene results in decreased expression of EXOC2 mRNA

NCBI chr17:33,714,949...33,906,901
Ensembl chr17:33,715,008...33,901,944

G

exo/endonuclease G

decreases methylation

ISO

Methapyrilene results in decreased methylation of EXOG intron

NCBI chr 8:128,062,688...128,082,529
Ensembl chr 8:128,059,126...128,083,460

G

exosome component 4

decreases expression

EXP

Methapyrilene results in decreased expression of EXOSC4 mRNA

NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820

G

exosome component 5

decreases expression

EXP

Methapyrilene results in decreased expression of EXOSC5 mRNA

NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:90,293,797...90,305,046

G

EYA transcriptional coactivator and phosphatase 1

increases methylation

ISO

Methapyrilene results in increased methylation of EYA1 intron

NCBI chr 5:9,646,599...9,884,609
Ensembl chr 5:9,646,591...9,884,614

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

decreases expression

EXP

Methapyrilene results in decreased expression of EZH1 mRNA

NCBI chr10:86,626,307...86,662,257
Ensembl chr10:86,626,308...86,652,620

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

increases methylation

ISO

Methapyrilene results in increased methylation of EZH2 intron

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

EZH inhibitory protein

decreases methylation

ISO

Methapyrilene results in decreased methylation of EZHIP promoter

NCBI chr X:19,040,397...19,043,463
Ensembl chr X:19,040,777...19,044,071

G

coagulation factor X

decreases expression

ISO

Methapyrilene results in decreased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280

G

coagulation factor V

decreases expression

EXP

Methapyrilene results in decreased expression of F5 mRNA

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247

G

coagulation factor VII

increases methylation

ISO

Methapyrilene results in increased methylation of F7 intron; Methapyrilene results in increased methylation of F7 promoter

NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738

G

coagulation factor VIII

increases methylation

ISO

Methapyrilene results in increased methylation of F8 intron

NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683

G

coagulation factor VIII-associated 1

decreases expression

EXP

Methapyrilene results in decreased expression of F8A1 mRNA

NCBI chr X:155,977,859...155,979,373
Ensembl chr X:155,976,941...156,108,974

G

FA core complex associated protein 20

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAAP20 intron

NCBI chr 5:171,083,328...171,097,599
Ensembl chr 5:171,087,847...171,097,599

G

fatty acid binding protein 1

decreases expression
increases expression

EXP
ISO

Methapyrilene results in decreased expression of FABP1 mRNA
Methapyrilene results in increased expression of FABP1 mRNA

PMID:15120968 PMID:28935588 PMID:30467583

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

fatty acid binding protein 12

decreases expression

EXP

Methapyrilene results in decreased expression of FABP12 mRNA

NCBI chr 2:93,446,966...93,462,393
Ensembl chr 2:93,407,956...93,462,390

G

fatty acid binding protein 6

increases methylation

ISO

Methapyrilene results in increased methylation of FABP6 intron

NCBI chr10:28,565,054...28,569,727
Ensembl chr10:28,565,054...28,573,058

G

fatty acid binding protein 7

decreases expression

EXP

Methapyrilene results in decreased expression of FABP7 mRNA

NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,669,601...37,675,907

G

fumarylacetoacetate hydrolase

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of FAH mRNA
Methapyrilene results in increased methylation of FAH intron

PMID:30157460 PMID:30467583

NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:147,957,935...147,981,046

G

fumarylacetoacetate hydrolase domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of FAHD1 mRNA

NCBI chr10:14,378,058...14,379,497
Ensembl chr10:14,378,120...14,379,867

G

family with sequence similarity 107, member B

increases methylation
increases expression

ISO
EXP

Methapyrilene results in increased methylation of FAM107B intron
Methapyrilene results in increased expression of FAM107B mRNA

PMID:30157460 PMID:30467583

NCBI chr17:79,387,795...79,594,165
Ensembl chr17:79,387,795...79,594,288

G

family with sequence similarity 117, member A

increases methylation

ISO

Methapyrilene results in increased methylation of FAM117A intron

NCBI chr10:80,778,229...80,822,119
Ensembl chr10:80,755,883...80,822,119

G

family with sequence similarity 117, member B

decreases expression

EXP

Methapyrilene results in decreased expression of FAM117B mRNA

NCBI chr 9:68,834,334...68,902,543
Ensembl chr 9:68,834,354...68,902,543

G

family with sequence similarity 120 member B

decreases expression

EXP

Methapyrilene results in decreased expression of FAM120B mRNA

NCBI chr 1:64,993,104...65,058,160
Ensembl chr 1:65,012,060...65,058,160

G

family with sequence similarity 120 member C

affects methylation

ISO

Methapyrilene affects the methylation of FAM120C intron

NCBI chr X:23,765,089...23,922,059
Ensembl chr X:23,766,976...23,920,840

G

family with sequence similarity 13, member A

affects methylation

ISO

Methapyrilene affects the methylation of FAM13A intron

NCBI chr 4:89,386,685...89,485,940
Ensembl chr 4:89,388,569...89,485,988

G

FAM161 centrosomal protein B

increases methylation

ISO

Methapyrilene results in increased methylation of FAM161B intron

NCBI chr 6:109,722,073...109,750,003
Ensembl chr 6:109,722,569...109,750,036

G

family with sequence similarity 162, member A

increases expression

EXP

Methapyrilene results in increased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

family with sequence similarity 168, member A

decreases expression

EXP

Methapyrilene results in decreased expression of FAM168A mRNA

NCBI chr 1:164,469,447...164,615,542
Ensembl chr 1:164,469,471...164,615,506

G

family with sequence similarity 169, member B

increases methylation

ISO

Methapyrilene results in increased methylation of FAM169BP intron

NCBI chr 1:131,288,780...131,378,548
Ensembl chr 1:131,288,799...131,370,145

G

family with sequence similarity 171, member A1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM171A1 intron

NCBI chr17:79,933,742...80,057,495
Ensembl chr17:79,934,050...80,057,495

G

family with sequence similarity 178, member B

increases methylation

ISO

Methapyrilene results in increased methylation of FAM178B intron

NCBI chr 9:46,301,734...46,409,571
Ensembl chr 9:46,301,734...46,410,686

G

FAM20A, golgi associated secretory pathway pseudokinase

increases methylation

ISO

Methapyrilene results in increased methylation of FAM20A intron

NCBI chr10:95,136,799...95,197,176
Ensembl chr10:95,142,458...95,197,053

G

FAM20C, golgi associated secretory pathway kinase

increases methylation

ISO

Methapyrilene results in increased methylation of FAM20C intron

NCBI chr12:20,940,654...20,999,072
Ensembl chr12:20,940,654...20,998,318

G

family with sequence similarity 210, member A

decreases expression

EXP

Methapyrilene results in decreased expression of FAM210A mRNA

NCBI chr18:64,116,274...64,155,971
Ensembl chr18:64,116,274...64,155,949

G

family with sequence similarity 222, member A

increases methylation

ISO

Methapyrilene results in increased methylation of FAM222A intron

NCBI chr12:47,647,221...47,693,703
Ensembl chr12:47,647,405...47,693,703

G

FAM3 metabolism regulating signaling molecule B

increases methylation

ISO

Methapyrilene results in increased methylation of FAM3B intron

NCBI chr11:50,300,926...50,333,296
Ensembl chr11:50,300,926...50,347,339

G

FAM3 metabolism regulating signaling molecule D

increases methylation

ISO

Methapyrilene results in increased methylation of FAM3D intron

NCBI chr15:18,969,737...19,003,276
Ensembl chr15:18,969,737...19,004,701

G

family with sequence similarity 47, member E

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM47E intron

NCBI chr14:15,769,441...15,805,911
Ensembl chr14:15,769,050...15,806,061

G

family with sequence similarity 53, member B

increases methylation

ISO

Methapyrilene results in increased methylation of FAM53B intron

NCBI chr 1:196,930,170...197,021,290
Ensembl chr 1:196,930,175...197,021,290

G

family with sequence similarity 78, member A

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM78A intron

NCBI chr 3:35,753,712...35,771,600
Ensembl chr 3:35,753,712...35,770,448

G

family with sequence similarity 83, member B

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM83B intron

NCBI chr 8:86,167,778...86,244,222
Ensembl chr 8:86,167,778...86,244,222

G

family with sequence similarity 83, member F

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM83F exon; Methapyrilene results in decreased methylation of FAM83F intron

NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:114,091,335...114,120,638

G

family with sequence similarity 83, member G

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAM83G polyA tail

NCBI chr10:46,862,983...46,887,499
Ensembl chr10:46,862,369...46,886,277

G

family with sequence similarity 89, member B

increases expression

EXP

Methapyrilene results in increased expression of FAM89B mRNA

NCBI chr 1:212,445,101...212,447,164
Ensembl chr 1:212,445,102...212,446,738

G

family with sequence similarity 8, member A1

decreases expression

EXP

Methapyrilene results in decreased expression of FAM8A1 mRNA

NCBI chr17:18,232,834...18,241,736
Ensembl chr17:18,232,834...18,241,703

G

FA complementation group C

affects methylation

ISO

Methapyrilene affects the methylation of FANCC intron

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,687,017...1,835,096

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FARP1 intron

NCBI chr15:104,531,196...104,770,148
Ensembl chr15:104,531,813...104,770,147

G

FERM, ARH/RhoGEF and pleckstrin domain protein 2

decreases expression

EXP

Methapyrilene results in decreased expression of FARP2 mRNA

NCBI chr 9:101,501,061...101,609,092
Ensembl chr 9:101,501,102...101,609,086

G

fatty acid synthase

decreases expression

EXP

Methapyrilene results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

FAT atypical cadherin 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of FAT2 exon

NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,864,766...39,956,902

G

fibulin 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBLN1 intron

NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965

G

fibulin 2

increases methylation

ISO

Methapyrilene results in increased methylation of FBLN2 intron; Methapyrilene results in increased methylation of FBLN2 promoter

NCBI chr 4:125,261,464...125,321,030
Ensembl chr 4:125,261,607...125,321,029

G

fibulin 5

increases methylation

ISO

Methapyrilene results in increased methylation of FBLN5 intron

NCBI chr 6:126,664,100...126,742,847
Ensembl chr 6:126,664,100...126,746,296

G

fibulin 7

affects methylation

ISO

Methapyrilene affects the methylation of FBLN7 intron

NCBI chr 3:136,564,825...136,601,205
Ensembl chr 3:136,564,917...136,601,198

G

fibrillin 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBN1 intron

NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283

G

fructose-bisphosphatase 1

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of FBP1 mRNA
Methapyrilene results in increased methylation of FBP1 intron

PMID:16393664 PMID:30157460 PMID:30467583

NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,213,492...2,235,746

G

fructose-bisphosphatase 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBP2 intron

NCBI chr17:2,241,767...2,259,371
Ensembl chr17:2,241,975...2,259,366

G

F-box and leucine-rich repeat protein 20

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBXL20 3' UTR

NCBI chr10:83,577,038...83,640,022
Ensembl chr10:83,577,038...83,639,977

G

F-box and leucine-rich repeat protein 7

affects methylation

ISO

Methapyrilene affects the methylation of FBXL7 intron

NCBI chr 2:78,870,236...79,239,697
Ensembl chr 2:78,871,287...79,239,697

G

F-box protein 17

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBXO17 exon

NCBI chr 1:93,129,776...93,151,983
Ensembl chr 1:93,129,849...93,151,981

G

F-box protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of FBXO3 mRNA

NCBI chr 3:110,872,185...110,904,479
Ensembl chr 3:110,872,220...110,904,479

G

F-box protein 31

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBXO31 intron

NCBI chr19:66,533,437...66,564,674
Ensembl chr19:66,533,437...66,564,674

G

F-box protein 6

increases methylation

ISO

Methapyrilene results in increased methylation of FBXO6 intron

NCBI chr 5:163,859,909...163,865,693
Ensembl chr 5:163,859,916...163,865,574

G

F-box protein 8

decreases expression

EXP

Methapyrilene results in decreased expression of FBXO8 mRNA

NCBI chr16:38,676,011...38,721,849
Ensembl chr16:38,676,014...38,721,906

G

f-box protein 9

decreases expression

EXP

Methapyrilene results in decreased expression of FBXO9 mRNA

NCBI chr 8:87,838,787...87,864,362
Ensembl chr 8:87,838,789...87,864,504

G

F-box and WD repeat domain containing 10

increases methylation

ISO

Methapyrilene results in increased methylation of FBXW10 intron

NCBI chr10:48,012,555...48,051,136
Ensembl chr10:47,958,677...48,051,136

G

F-box and WD repeat domain containing 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of FBXW8 intron

NCBI chr12:44,087,375...44,177,985
Ensembl chr12:44,087,375...44,177,985

G

Fc gamma receptor and transporter

increases methylation

ISO

Methapyrilene results in increased methylation of FCGRT intron

NCBI chr 1:104,710,902...104,720,685
Ensembl chr 1:104,710,909...104,720,532

G

FCH and mu domain containing endocytic adaptor 1

increases methylation

ISO

Methapyrilene results in increased methylation of FCHO1 intron

NCBI chr16:18,447,424...18,464,738
Ensembl chr16:18,447,424...18,464,698

G

FCH and mu domain containing endocytic adaptor 2

decreases expression

EXP

Methapyrilene results in decreased expression of FCHO2 mRNA

NCBI chr 2:31,813,356...31,916,471
Ensembl chr 2:31,814,950...31,915,445

G

FCH and double SH3 domains 2

decreases expression

EXP

Methapyrilene results in decreased expression of FCHSD2 mRNA

NCBI chr 1:164,775,916...165,097,391
Ensembl chr 1:164,775,926...165,097,391

G

ferredoxin 2

increases methylation

ISO

Methapyrilene results in increased methylation of FDX2 promoter

NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:27,881,091...27,886,015

G

ferredoxin-fold anticodon binding domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of FDXACB1 mRNA

NCBI chr 8:60,009,818...60,014,625

G

FERM domain containing kindlin 1

increases methylation

ISO

Methapyrilene results in increased methylation of FERMT1 intron

NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:140,624,434...140,666,419

G

FERM domain containing kindlin 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of FERMT3 intron

NCBI chr 1:213,618,691...213,636,889
Ensembl chr 1:213,618,208...213,636,273

G

fetuin B

decreases expression

EXP

Methapyrilene results in decreased expression of FETUB mRNA

NCBI chr11:91,586,750...91,599,789
Ensembl chr11:91,586,748...91,599,310

G

free fatty acid receptor 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of FFAR4 intron

NCBI chr 1:245,286,009...245,304,029
Ensembl chr 1:245,285,883...245,304,031

G

fibrinogen alpha chain

decreases expression

EXP

Methapyrilene results in decreased expression of FGA mRNA

PMID:15120968 PMID:30467583

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

FYVE, RhoGEF and PH domain containing 4

increases methylation

ISO

Methapyrilene results in increased methylation of FGD4 promoter

NCBI chr11:97,904,182...98,055,190
Ensembl chr11:97,904,182...98,055,190

G

FYVE, RhoGEF and PH domain containing 5

increases methylation

ISO

Methapyrilene results in increased methylation of FGD5 exon; Methapyrilene results in increased methylation of FGD5 intron

NCBI chr 4:126,054,201...126,151,698
Ensembl chr 4:126,054,210...126,151,697

G

fibroblast growth factor 1

increases methylation

ISO

Methapyrilene results in increased methylation of FGF1 intron

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393

G

fibroblast growth factor 12

affects methylation

ISO

Methapyrilene affects the methylation of FGF12 intron

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 14

increases methylation

ISO

Methapyrilene results in increased methylation of FGF14 intron

NCBI chr15:107,442,800...108,086,486
Ensembl chr15:107,451,634...108,085,808

G

fibroblast growth factor 21

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of FGF21 mRNA
Methapyrilene results in decreased expression of FGF21 mRNA

PMID:22484513 PMID:30467583

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

FGGY carbohydrate kinase domain containing

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of FGGY mRNA
Methapyrilene results in increased methylation of FGGY intron

PMID:30157460 PMID:30467583

NCBI chr 5:115,514,573...115,901,713
Ensembl chr 5:115,472,211...115,901,714

G

fumarate hydratase

increases expression

EXP

Methapyrilene results in increased expression of FH protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

forkhead associated phosphopeptide binding domain 1

increases methylation

ISO

Methapyrilene results in increased methylation of FHAD1 intron

NCBI chr 5:159,474,111...159,593,455
Ensembl chr 5:159,474,158...159,593,367

G

fragile histidine triad diadenosine triphosphatase

affects methylation
increases expression

ISO

Methapyrilene affects the methylation of FHIT intron
Methapyrilene results in increased expression of FHIT mRNA

PMID:30157460 PMID:35690182

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621

G

four and a half LIM domains 1

increases expression

EXP

Methapyrilene results in increased expression of FHL1 mRNA

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:139,592,604...139,652,282

G

formin homology 2 domain containing 3

affects methylation

ISO

Methapyrilene affects the methylation of FHOD3 intron

NCBI chr18:16,267,830...16,700,508
Ensembl chr18:16,267,977...16,700,508

G

FGF1 intracellular binding protein

decreases methylation

ISO

Methapyrilene results in decreased methylation of FIBP exon

NCBI chr 1:212,197,216...212,201,732
Ensembl chr 1:212,197,416...212,201,731

G

filamin A interacting protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FILIP1 intron

NCBI chr 8:89,641,509...89,836,772
Ensembl chr 8:89,644,579...89,802,771

G

filamin A interacting protein 1-like

increases methylation

ISO

Methapyrilene results in increased methylation of FILIP1L intron

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:56,410,582...56,646,402

G

FKBP prolyl isomerase 4

increases expression

EXP

Methapyrilene results in increased expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918

G

FKBP prolyl isomerase 5

decreases expression

EXP

Methapyrilene results in decreased expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

flavin adenine dinucleotide synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of FLAD1 mRNA

NCBI chr 2:177,117,183...177,126,650
Ensembl chr 2:177,117,655...177,126,650

G

folliculin

decreases methylation

ISO

Methapyrilene results in decreased methylation of FLCN intron

NCBI chr10:45,088,164...45,107,581
Ensembl chr10:45,088,167...45,107,309

G

Fli-1 proto-oncogene, ETS transcription factor

increases methylation

ISO

Methapyrilene results in increased methylation of FLI1 intron

NCBI chr 8:39,089,526...39,209,511
Ensembl chr 8:39,089,533...39,208,557

G

filamin A

increases methylation

ISO

Methapyrilene results in increased methylation of FLNA exon

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:157,159,051...157,182,343

G

filamin B

decreases expression

EXP

Methapyrilene results in decreased expression of FLNB mRNA

NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209

G

Fms related receptor tyrosine kinase 1

increases methylation

ISO

Methapyrilene results in increased methylation of FLT1 intron

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

Fms related receptor tyrosine kinase 3

increases methylation

ISO

Methapyrilene results in increased methylation of FLT3 intron

NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581

G

FLVCR choline and putative heme transporter 2

increases methylation

ISO

Methapyrilene results in increased methylation of FLVCR2 intron

NCBI chr 6:111,139,352...111,203,345
Ensembl chr 6:111,139,295...111,203,345

G

formin 1

increases methylation

ISO

Methapyrilene results in increased methylation of FMN1 intron

NCBI chr 3:120,555,445...120,939,978
Ensembl chr 3:120,555,431...120,933,124

G

formin 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of FMN2 intron

NCBI chr13:88,986,863...89,303,789
Ensembl chr13:88,986,842...89,303,789

G

formin-like 2

increases methylation

ISO

Methapyrilene results in increased methylation of FMNL2 intron

NCBI chr 3:57,758,236...58,033,832
Ensembl chr 3:57,758,191...58,033,831

G

formin-like 3

increases methylation

ISO

Methapyrilene results in increased methylation of FMNL3 intron

NCBI chr 7:132,333,130...132,384,483
Ensembl chr 7:132,333,130...132,384,483

G

flavin containing dimethylaniline monoxygenase 5

decreases expression

EXP

Methapyrilene results in decreased expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

fibronectin 1

decreases expression

EXP

Methapyrilene results in decreased expression of FN1 mRNA

PMID:15890375 PMID:30467583

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

fibronectin type III domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of FNDC1 intron

NCBI chr 1:49,686,856...49,769,263
Ensembl chr 1:49,686,856...49,769,263

G

fibronectin type III domain containing 3a

decreases expression

EXP

Methapyrilene results in decreased expression of FNDC3A mRNA

NCBI chr15:54,099,510...54,276,963
Ensembl chr15:54,099,510...54,276,407

G

fibronectin type III domain containing 3B

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of FNDC3B intron
Methapyrilene results in decreased expression of FNDC3B mRNA

PMID:30157460 PMID:30467583

NCBI chr 2:112,240,108...112,546,113
Ensembl chr 2:112,243,202...112,546,306

G

fibronectin type III domain containing 5

increases methylation

ISO

Methapyrilene results in increased methylation of FNDC5 intron

NCBI chr 5:146,765,951...146,775,611
Ensembl chr 5:146,751,416...146,778,540

G

farnesyltransferase, CAAX box, subunit beta

decreases methylation

ISO

Methapyrilene results in decreased methylation of FNTB intron

NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Methapyrilene results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

increases expression

EXP

Methapyrilene results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box N3

increases methylation

ISO

Methapyrilene results in increased methylation of FOXN3 intron

NCBI chr 6:124,191,695...124,572,070
Ensembl chr 6:124,195,701...124,572,040

G

forkhead box N4

decreases methylation

ISO

Methapyrilene results in decreased methylation of FOXN4 intron

NCBI chr12:47,997,308...48,020,526
Ensembl chr12:48,000,257...48,020,526

G

forkhead box O3

increases methylation

ISO

Methapyrilene results in increased methylation of FOXO3 intron

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

forkhead box O6

decreases methylation

ISO

Methapyrilene results in decreased methylation of FOXO6 intron

NCBI chr 5:139,141,329...139,161,629
Ensembl chr 5:139,141,185...139,161,629

G

forkhead box P1

decreases expression

EXP

Methapyrilene results in decreased expression of FOXP1 mRNA

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272

G

forkhead box P2

increases methylation

ISO

Methapyrilene results in increased methylation of FOXP2 intron

NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696

G

FAD-dependent oxidoreductase domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of FOXRED1 mRNA

NCBI chr 8:41,789,557...41,818,064
Ensembl chr 8:41,808,843...41,817,980

G

folylpolyglutamate synthase

decreases expression

EXP

Methapyrilene results in decreased expression of FPGS mRNA

NCBI chr 3:36,370,505...36,391,314
Ensembl chr 3:36,370,300...36,391,068

G

FRA10A associated CGG repeat 1

decreases expression

EXP

Methapyrilene results in decreased expression of FRA10AC1 mRNA

NCBI chr 1:245,381,538...245,413,879
Ensembl chr 1:245,366,451...245,414,189

G

Fras1 related extracellular matrix 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FREM1 intron

NCBI chr 5:102,367,201...102,515,464
Ensembl chr 5:102,367,201...102,515,404

G

FRAS1 related extracellular matrix 2

decreases expression

ISO

Methapyrilene results in decreased expression of FREM2 mRNA

NCBI chr 2:139,753,055...139,891,046
Ensembl chr 2:139,753,055...139,891,046

G

FERM domain containing 4A

affects methylation

ISO

Methapyrilene affects the methylation of FRMD4A intron

NCBI chr17:78,577,062...79,167,924
Ensembl chr17:78,579,277...79,167,663

G

FERM domain containing 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of FRMD8 intron

NCBI chr 1:212,572,534...212,593,181
Ensembl chr 1:212,572,537...212,592,695

G

FERM and PDZ domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of FRMPD1 intron

NCBI chr 5:64,238,730...64,340,778
Ensembl chr 5:64,238,768...64,340,776

G

FERM and PDZ domain containing 3

increases methylation

ISO

Methapyrilene results in increased methylation of FRMPD3 intron

NCBI chr X:108,752,511...108,902,393
Ensembl chr X:108,752,716...108,901,496

G

fibronectin type III and SPRY domain containing 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of FSD2 intron

NCBI chr 1:144,898,499...144,931,753
Ensembl chr 1:144,898,502...144,931,704

G

follistatin

increases expression

EXP

Methapyrilene results in increased expression of FST mRNA

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

follistatin-like 4

increases methylation

ISO

Methapyrilene results in increased methylation of FSTL4 exon; Methapyrilene results in increased methylation of FSTL4 intron

NCBI chr10:37,412,288...37,845,405
Ensembl chr10:37,412,288...37,845,393

G

follistatin-like 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of FSTL5 intron

NCBI chr 2:163,156,576...163,825,140
Ensembl chr 2:163,156,576...163,825,140

G

formimidoyltransferase cyclodeaminase

decreases expression

EXP

Methapyrilene results in decreased expression of FTCD mRNA

NCBI chr20:12,054,710...12,068,219
Ensembl chr20:12,054,711...12,068,237

G

ferritin light chain 1

decreases expression
increases expression

ISO
EXP

Methapyrilene results in decreased expression of FTL mRNA
Methapyrilene results in increased expression of FTL protein
Methapyrilene results in increased expression of FTL mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

FTO, alpha-ketoglutarate dependent dioxygenase

decreases methylation

ISO

Methapyrilene results in decreased methylation of FTO intron

NCBI chr19:31,456,749...31,865,011
Ensembl chr19:31,522,293...31,864,957

G

FTX transcript, XIST regulator

increases methylation

ISO

Methapyrilene results in increased methylation of FTX intron

NCBI chr X:72,654,112...72,696,097

G

far upstream element binding protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of FUBP3 mRNA

NCBI chr 3:35,253,216...35,302,282
Ensembl chr 3:35,253,306...35,302,280

G

FUN14 domain containing 2

decreases expression

EXP

Methapyrilene results in decreased expression of FUNDC2 mRNA

NCBI chr18:142,829...155,123
Ensembl chr18:142,640...155,674

G

forty-two-three domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of FYTTD1 mRNA

NCBI chr11:81,383,040...81,412,604
Ensembl chr11:81,383,040...81,412,599

G

G2 protein

increases methylation

ISO

Methapyrilene results in increased methylation of KIAA1549L intron

NCBI chr 3:110,961,478...111,237,308
Ensembl chr 3:110,961,478...111,237,223

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

EXP

Methapyrilene results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with Methapyrilene] results in increased expression of G6PD protein
Methapyrilene results in increased expression of G6PD mRNA

PMID:28903497 PMID:30467583

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GABA type A receptor associated protein like 2

increases expression

EXP

Methapyrilene results in increased expression of GABARAPL2 mRNA

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660

G

gamma-aminobutyric acid type B receptor subunit 2

increases methylation

ISO

Methapyrilene results in increased methylation of GABBR2 intron

NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:65,743,073...66,083,695

G

GA binding protein transcription factor subunit alpha

decreases expression

EXP

Methapyrilene results in decreased expression of GABPA mRNA

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

GA binding protein transcription factor subunit beta 2

increases methylation

ISO

Methapyrilene results in increased methylation of GABPB2 polyA tail

NCBI chr 2:185,444,309...185,484,200
Ensembl chr 2:185,450,296...185,483,589

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GABRA1 polyA tail

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit alpha 3

increases methylation

ISO

Methapyrilene results in increased methylation of GABRA3 exon; Methapyrilene results in increased methylation of GABRA3 intron

NCBI chr X:155,301,979...155,543,870
Ensembl chr X:155,303,928...155,543,863

G

gamma-aminobutyric acid type A receptor subunit delta

increases methylation

ISO

Methapyrilene results in increased methylation of GABRD intron

NCBI chr 5:171,240,813...171,252,709
Ensembl chr 5:171,240,789...171,253,094

G

gamma-aminobutyric acid type A receptor subunit rho 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GABRR1 intron

NCBI chr 5:52,320,475...52,357,549
Ensembl chr 5:52,320,475...52,357,549

G

growth arrest and DNA-damage-inducible, alpha

increases expression

EXP

Methapyrilene results in increased expression of GADD45A mRNA

PMID:15890375 PMID:22484513 PMID:25242409 PMID:28935588

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

increases expression

EXP

Methapyrilene results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

cyclin G associated kinase

increases methylation

ISO

Methapyrilene results in increased methylation of GAK intron

NCBI chr14:1,234,272...1,308,492
Ensembl chr14:1,234,266...1,323,974

G

galactose-3-O-sulfotransferase 2

increases methylation

ISO

Methapyrilene results in increased methylation of GAL3ST2 polyA tail

NCBI chr 9:101,823,815...101,836,507
Ensembl chr 9:101,823,815...101,836,507

G

galactose mutarotase

decreases expression

EXP

Methapyrilene results in decreased expression of GALM mRNA

NCBI chr 6:20,589,775...20,641,516
Ensembl chr 6:20,589,776...20,644,417

G

galactosamine (N-acetyl)-6-sulfatase

increases methylation

ISO

Methapyrilene results in increased methylation of GALNS intron

NCBI chr19:67,537,175...67,570,900
Ensembl chr19:67,534,737...67,571,191

G

polypeptide N-acetylgalactosaminyltransferase 11

decreases expression

EXP

Methapyrilene results in decreased expression of GALNT11 mRNA

NCBI chr 4:10,571,464...10,604,974
Ensembl chr 4:10,571,464...10,604,974

G

polypeptide N-acetylgalactosaminyltransferase 17

increases methylation

ISO

Methapyrilene results in increased methylation of WBSCR17 intron

NCBI chr12:30,959,460...31,418,150
Ensembl chr12:30,959,447...31,418,149

G

polypeptide N-acetylgalactosaminyltransferase 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of GALNT2 intron

NCBI chr19:69,110,657...69,222,237
Ensembl chr19:69,110,657...69,222,237

G

polypeptide N-acetylgalactosaminyltransferase 8

increases methylation

ISO

Methapyrilene results in increased methylation of GALNT8 promoter

NCBI chr 4:161,307,603...161,336,485

G

polypeptide N-acetylgalactosaminyltransferase-like 6

increases methylation

ISO

Methapyrilene results in increased methylation of GALNTL6 intron

NCBI chr16:36,203,674...37,454,709
Ensembl chr16:36,204,614...37,452,780

G

glucosidase II alpha subunit

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of GANAB intron; Methapyrilene results in increased methylation of GANAB promoter
Methapyrilene results in decreased expression of GANAB mRNA

PMID:30157460 PMID:30467583

NCBI chr 1:215,222,918...215,242,808
Ensembl chr 1:215,222,995...215,243,036

G

growth associated protein 43

increases methylation

ISO

Methapyrilene results in increased methylation of GAP43 exon

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

GTPase activating protein and VPS9 domains 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GAPVD1 intron

NCBI chr 3:38,365,854...38,439,403
Ensembl chr 3:38,365,854...38,439,390

G

GRB2 associated regulator of MAPK1 subtype 1

increases methylation

ISO

Methapyrilene results in increased methylation of GAREM intron

NCBI chr18:12,695,082...12,860,219
Ensembl chr18:12,695,082...12,860,219

G

growth arrest-specific 2

decreases expression

EXP

Methapyrilene results in decreased expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:110,717,312...110,718,541

G

growth arrest specific 6

increases expression

EXP

Methapyrilene results in increased expression of GAS6 mRNA

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

growth arrest specific 7

increases methylation

ISO

Methapyrilene results in increased methylation of GAS7 exon; Methapyrilene results in increased methylation of GAS7 intron

NCBI chr10:52,651,690...52,882,244
Ensembl chr10:52,651,690...52,882,244

G

GATA binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of GATA2 exon; Methapyrilene results in increased methylation of GATA2 polyA tail

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

GATA zinc finger domain containing 2A

increases methylation

ISO

Methapyrilene results in increased methylation of GATAD2A intron

NCBI chr16:19,463,500...19,553,497
Ensembl chr16:19,463,500...19,553,497

G

glutamine amidotransferase class 1 domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GATD1 exon

NCBI chr 1:205,936,189...205,942,121
Ensembl chr 1:205,936,687...205,942,779

G

glucosylceramidase beta 3

increases methylation

ISO

Methapyrilene results in increased methylation of GBA3 intron

NCBI chr14:64,787,601...64,934,043
Ensembl chr14:64,787,601...64,934,043

G

1,4-alpha-glucan branching enzyme 1

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of GBE1 intron
Methapyrilene results in decreased expression of GBE1 mRNA

PMID:30157460 PMID:30467583

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)

increases methylation

ISO

Methapyrilene results in increased methylation of GBGT1 5' UTR

NCBI chr 3:32,219,370...32,227,737

G

grancalcin

decreases expression

EXP

Methapyrilene results in decreased expression of GCA mRNA

NCBI chr 3:67,705,874...67,738,475
Ensembl chr 3:67,705,890...67,737,387

G

glucagon receptor

increases methylation

ISO

Methapyrilene results in increased methylation of GCGR intron

NCBI chr10:106,306,803...106,314,970
Ensembl chr10:106,306,559...106,314,969

G

glucokinase regulator

decreases expression

EXP

Methapyrilene results in decreased expression of GCKR mRNA

NCBI chr 6:30,765,071...30,795,627
Ensembl chr 6:30,765,075...30,795,627

G

glutamate-cysteine ligase, catalytic subunit

increases expression

EXP

Methapyrilene results in increased expression of GCLC mRNA; Methapyrilene results in increased expression of GCLC protein

PMID:15890375 PMID:19523481 PMID:28935588 PMID:30467583

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glial cells missing transcription factor 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GCM1 intron

NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:87,805,993...87,819,229

G

glucosaminyl (N-acetyl) transferase family member 7

increases methylation

ISO

Methapyrilene results in increased methylation of GCNT7 intron

NCBI chr 3:181,637,406...181,647,839
Ensembl chr 3:181,637,406...181,641,460

G

guanine deaminase

increases methylation

ISO

Methapyrilene results in increased methylation of GDA intron

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

growth differentiation factor 15

increases expression

EXP

Methapyrilene results in increased expression of GDF15 mRNA

PMID:15890375 PMID:30467583

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

growth differentiation factor 3

increases methylation

ISO

Methapyrilene results in increased methylation of GDF3 intron

NCBI chr 4:157,503,547...157,507,923
Ensembl chr 4:157,502,884...157,507,907

G

glycerophosphodiester phosphodiesterase domain containing 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of GDPD5 intron

NCBI chr 1:163,091,844...163,173,559
Ensembl chr 1:163,091,833...163,173,559

G

glial fibrillary acidic protein

decreases methylation

ISO

Methapyrilene results in decreased methylation of GFAP exon

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

G elongation factor, mitochondrial 1

decreases expression

EXP

Methapyrilene results in decreased expression of GFM1 mRNA

NCBI chr 2:154,010,601...154,055,523
Ensembl chr 2:154,010,614...154,065,805

G

GDNF family receptor alpha 1

decreases expression

EXP

Methapyrilene results in decreased expression of GFRA1 mRNA

NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501

G

GDNF family receptor alpha 2

increases methylation

ISO

Methapyrilene results in increased methylation of GFRA2 3' UTR; Methapyrilene results in increased methylation of GFRA2 intron

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

gamma-glutamyl carboxylase

decreases expression

EXP

Methapyrilene results in decreased expression of GGCX mRNA

NCBI chr 4:106,027,918...106,043,653
Ensembl chr 4:106,027,912...106,043,923

G

gamma-glutamyltransferase 5

increases methylation

ISO

Methapyrilene results in increased methylation of GGT5 intron

NCBI chr20:13,042,694...13,070,960
Ensembl chr20:13,042,696...13,070,892

G

growth hormone inducible transmembrane protein

decreases expression

EXP

Methapyrilene results in decreased expression of GHITM mRNA

NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123

G

growth hormone receptor

increases expression

EXP

Methapyrilene results in increased expression of GHR mRNA

NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331

G

gypsy retrotransposon integrase 1

decreases expression

EXP

Methapyrilene results in decreased expression of GIN1 mRNA

NCBI chr 9:105,740,914...105,762,357
Ensembl chr 9:105,742,094...105,762,357

G

gap junction protein, beta 1

increases methylation

ISO

Methapyrilene results in increased methylation of GJB1 intron

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

gap junction protein, beta 2

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of GJB2 mRNA
Methapyrilene results in increased methylation of GJB2 promoter

PMID:30157460 PMID:30467583

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

gap junction protein, beta 4

increases methylation

ISO

Methapyrilene results in increased methylation of GJB4 exon

NCBI chr 5:144,948,231...144,964,014
Ensembl chr 5:144,951,184...144,964,097

G

gap junction protein, delta 3

decreases methylation
increases expression

ISO

Methapyrilene results in decreased methylation of GJD3 promoter
Methapyrilene results in increased expression of GJD3 mRNA

NCBI chr10:84,429,923...84,432,011
Ensembl chr10:84,429,036...84,433,870

G

glycerol kinase

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of GK promoter
Methapyrilene results in decreased expression of GK mRNA

PMID:30157460 PMID:30467583

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

glycine decarboxylase

decreases expression

EXP

Methapyrilene results in decreased expression of GLDC mRNA

NCBI chr 1:237,296,753...237,375,620
Ensembl chr 1:237,296,753...237,375,604

G

GLI family zinc finger 2

affects methylation
decreases methylation

ISO

Methapyrilene affects the methylation of GLI2 intron
Methapyrilene results in decreased methylation of GLI2 polyA tail

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

GLIS family zinc finger 1

increases methylation

ISO

Methapyrilene results in increased methylation of GLIS1 intron

NCBI chr 5:127,450,934...127,640,929
Ensembl chr 5:127,451,293...127,640,928

G

GLIS family zinc finger 2

increases methylation

ISO

Methapyrilene results in increased methylation of GLIS2 intron

NCBI chr10:11,457,594...11,484,948
Ensembl chr10:11,457,792...11,477,995

G

glyoxalase domain containing 4

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of GLOD4 mRNA
Methapyrilene results in increased methylation of GLOD4 intron

PMID:30157460 PMID:30467583

NCBI chr10:61,575,770...61,594,111

G

glutaminase 2

decreases expression

EXP

Methapyrilene results in decreased expression of GLS2 mRNA

NCBI chr 7:1,201,757...1,218,014
Ensembl chr 7:1,201,838...1,218,013

G

glycosyltransferase 1 domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of GLT1D1 intron

NCBI chr12:34,611,942...34,685,591
Ensembl chr12:34,612,643...34,685,468

G

glycosyltransferase 8 domain containing 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of GLT8D2 intron

NCBI chr 7:22,917,055...22,968,616
Ensembl chr 7:22,917,100...22,968,930

G

glutamate dehydrogenase 1

decreases expression

EXP

Methapyrilene results in decreased expression of GLUD1 mRNA

NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210

G

glycine-N-acyltransferase-like 2

decreases expression

EXP

Methapyrilene results in decreased expression of GLYATL2 mRNA

NCBI chr 1:219,232,154...219,265,142
Ensembl chr 1:219,232,103...219,266,322

G

glycerate kinase

decreases expression

EXP

Methapyrilene results in decreased expression of GLYCTK mRNA

NCBI chr 8:115,676,071...115,681,403
Ensembl chr 8:115,676,072...115,681,091

G

glyoxylate reductase 1 homolog

decreases expression

EXP

Methapyrilene results in decreased expression of GLYR1 mRNA

NCBI chr10:11,038,577...11,074,093
Ensembl chr10:11,038,568...11,074,090

G

GDP-mannose 4, 6-dehydratase

affects methylation

ISO

Methapyrilene affects the methylation of GMDS intron

NCBI chr17:32,304,029...32,830,708
Ensembl chr17:32,304,056...32,830,706

G

glucocorticoid modulatory element binding protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GMEB1 intron

NCBI chr 5:149,703,035...149,746,474
Ensembl chr 5:149,705,825...149,737,259

G

glia maturation factor, beta

decreases expression

EXP

Methapyrilene results in decreased expression of GMFB mRNA

NCBI chr15:22,549,705...22,560,125
Ensembl chr15:22,547,034...22,560,308

G

geminin, DNA replication inhibitor

increases expression

EXP

Methapyrilene results in increased expression of GMNN mRNA

NCBI chr17:40,729,760...40,738,077
Ensembl chr17:40,729,824...40,738,068

G

G protein subunit alpha 15

increases methylation

ISO

Methapyrilene results in increased methylation of GNA15 polyA tail

NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,835,357...8,856,268

G

G protein subunit alpha i1

decreases expression

EXP

Methapyrilene results in decreased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha o1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GNAO1 3' UTR; Methapyrilene results in decreased methylation of GNAO1 intron

NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437

G

G protein subunit beta 5

decreases expression

EXP

Methapyrilene results in decreased expression of GNB5 mRNA

NCBI chr 8:84,956,629...84,985,576
Ensembl chr 8:84,953,815...84,986,888

G

G protein subunit gamma 12

increases methylation

ISO

Methapyrilene results in increased methylation of GNG12 intron

NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476

G

G protein subunit gamma 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of GNG2 intron

NCBI chr15:4,365,222...4,466,060
Ensembl chr15:4,365,135...4,466,059

G

G protein subunit gamma 4

increases methylation

ISO

Methapyrilene results in increased methylation of GNG4 intron

NCBI chr17:93,432,791...93,481,709
Ensembl chr17:93,433,195...93,481,709

G

G protein subunit gamma 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of GNG7 intron

NCBI chr 7:9,348,148...9,411,924
Ensembl chr 7:9,348,218...9,411,923

G

G protein nucleolar 3 like

decreases expression

EXP

Methapyrilene results in decreased expression of GNL3L mRNA

NCBI chr X:23,404,324...23,437,501
Ensembl chr X:23,404,324...23,439,315

G

glycine N-methyltransferase

increases expression

EXP
ISO

Methapyrilene results in increased expression of GNMT protein
Methapyrilene results in increased expression of GNMT mRNA

PMID:30467583 PMID:35690182

NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692

G

glyceronephosphate O-acyltransferase

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of GNPAT mRNA
Methapyrilene results in decreased methylation of GNPAT intron

PMID:30157460 PMID:30467583

NCBI chr19:69,719,707...69,746,244
Ensembl chr19:69,719,394...69,746,244

G

golgin A3

decreases methylation

ISO

Methapyrilene results in decreased methylation of GOLGA3 intron

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

golgin A4

decreases expression

EXP

Methapyrilene results in decreased expression of GOLGA4 mRNA

NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603

G

golgin A5

decreases expression

EXP

Methapyrilene results in decreased expression of GOLGA5 mRNA

NCBI chr 6:127,377,244...127,405,404
Ensembl chr 6:127,377,236...127,405,403

G

golgi integral membrane protein 4

decreases expression

EXP

Methapyrilene results in decreased expression of GOLIM4 mRNA

NCBI chr 2:162,939,429...163,031,901
Ensembl chr 2:162,939,429...163,031,901

G

gon-4 like

decreases methylation

ISO

Methapyrilene results in decreased methylation of GON4L intron

NCBI chr 2:176,531,274...176,604,446
Ensembl chr 2:176,531,274...176,604,444

G

golgi SNAP receptor complex member 1

affects expression

EXP

Methapyrilene affects the expression of GOSR1 mRNA

NCBI chr10:62,068,662...62,105,442
Ensembl chr10:61,948,693...62,105,324

G

glutamic-oxaloacetic transaminase 1

decreases expression

EXP

Methapyrilene results in decreased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycoprotein A33

increases methylation

ISO

Methapyrilene results in increased methylation of GPA33 exon

NCBI chr13:80,914,119...80,947,738
Ensembl chr13:80,912,430...80,948,903

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

EXP

Methapyrilene results in decreased expression of GPAM mRNA

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

G patch domain and ankyrin repeats 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GPANK1 exon

NCBI chr20:3,702,309...3,705,476
Ensembl chr20:3,702,309...3,705,306

G

glycerol-3-phosphate acyltransferase 4

increases methylation

ISO

Methapyrilene results in increased methylation of GPAT4 intron

NCBI chr16:75,515,935...75,555,431
Ensembl chr16:75,521,640...75,557,847

G

G patch domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of GPATCH2 intron

NCBI chr13:101,316,413...101,457,109
Ensembl chr13:101,316,413...101,457,109

G

glypican 3

increases methylation

ISO

Methapyrilene results in increased methylation of GPC3 intron

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

glypican 4

decreases expression

EXP

Methapyrilene results in decreased expression of GPC4 mRNA

NCBI chr X:136,565,536...136,676,142
Ensembl chr X:136,565,591...136,676,057

G

glypican 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of GPC5 intron

NCBI chr15:98,614,499...100,051,285
Ensembl chr15:98,646,340...100,051,514

G

glycerophosphocholine phosphodiesterase 1

decreases expression

EXP

Methapyrilene results in decreased expression of GPCPD1 mRNA

NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372

G

glycerol-3-phosphate dehydrogenase 1

increases methylation

ISO

Methapyrilene results in increased methylation of GPD1 intron

NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368

G

gephyrin

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of GPHN mRNA
Methapyrilene results in increased methylation of GPHN intron

PMID:30157460 PMID:30467583

NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:102,687,423...103,216,674

G

glycosylphosphatidylinositol specific phospholipase D1

increases methylation

ISO

Methapyrilene results in increased methylation of GPLD1 intron

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

glycoprotein m6b

increases methylation

ISO

Methapyrilene results in increased methylation of GPM6B intron

NCBI chr X:31,689,485...31,836,199
Ensembl chr X:31,690,359...31,733,272

G

G protein-coupled receptor 107

decreases expression

EXP

Methapyrilene results in decreased expression of GPR107 mRNA

NCBI chr 3:34,832,462...34,893,692
Ensembl chr 3:34,832,480...34,893,654

G

G protein-coupled receptor 108

decreases methylation

ISO

Methapyrilene results in decreased methylation of GPR108 intron

NCBI chr 9:2,207,716...2,218,738
Ensembl chr 9:2,207,726...2,219,750

G

G protein-coupled receptor 137B

increases methylation

ISO

Methapyrilene results in increased methylation of GPR137B intron

NCBI chr17:92,987,792...93,026,003
Ensembl chr17:92,942,559...93,025,911

G

G protein-coupled receptor 146

decreases expression

EXP

Methapyrilene results in decreased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

G protein-coupled receptor 156

increases methylation

ISO

Methapyrilene results in increased methylation of GPR156 polyA tail

NCBI chr11:76,228,104...76,320,890
Ensembl chr11:76,228,104...76,320,890

G

G protein-coupled receptor 157

increases methylation

ISO

Methapyrilene results in increased methylation of GPR157 intron

NCBI chr 5:165,833,651...165,849,376
Ensembl chr 5:165,833,673...165,851,280

G

G protein-coupled receptor 32

increases methylation

ISO

Methapyrilene results in increased methylation of GPR32 exon

NCBI chr 1:103,893,405...103,894,667

G

G protein regulated inducer of neurite outgrowth 2

increases methylation

ISO

Methapyrilene results in increased methylation of GPRIN2 intron

NCBI chr16:9,502,697...9,518,901
Ensembl chr16:9,502,711...9,513,259

G

G-protein signaling modulator 1

increases methylation

ISO

Methapyrilene results in increased methylation of GPSM1 intron

NCBI chr 3:29,538,929...29,565,921
Ensembl chr 3:29,526,802...29,565,920

G

glutamic--pyruvic transaminase

increases expression
decreases expression
increases activity

EXP

Methapyrilene results in increased expression of GPT protein
Methapyrilene results in decreased expression of GPT mRNA
Methapyrilene results in increased activity of GPT protein

PMID:24863736 PMID:28529062 PMID:30467583

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamic--pyruvic transaminase 2

affects methylation

ISO

Methapyrilene affects the methylation of GPT2 intron

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917

G

glutathione peroxidase 2

increases expression

EXP

Methapyrilene results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 3

increases expression

EXP

Methapyrilene results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

GRAM domain containing 1B

increases methylation

ISO

Methapyrilene results in increased methylation of GRAMD1B intron

NCBI chr 8:49,551,642...49,790,965
Ensembl chr 8:49,556,332...49,791,052

G

GRB2-related adaptor protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of GRAP2 intron

NCBI chr 7:113,997,356...114,071,073
Ensembl chr 7:113,997,307...114,075,367

G

growth factor receptor bound protein 14

decreases expression

EXP

Methapyrilene results in decreased expression of GRB14 mRNA

NCBI chr 3:69,976,331...70,091,921
Ensembl chr 3:69,976,339...70,091,921

G

growth factor receptor bound protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of GRB2 intron

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

gene rich cluster, C10 gene

increases methylation

ISO

Methapyrilene results in increased methylation of C12ORF57 promoter

NCBI chr 4:159,237,562...159,239,223

G

growth regulating estrogen receptor binding 1

increases methylation

ISO

Methapyrilene results in increased methylation of GREB1 intron

NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126

G

glyoxylate and hydroxypyruvate reductase

decreases expression

ISO

Methapyrilene results in decreased expression of GRHPR mRNA

NCBI chr 5:64,029,856...64,039,287
Ensembl chr 5:64,022,368...64,039,276

G

glutamate ionotropic receptor delta type subunit 1

affects methylation

ISO

Methapyrilene affects the methylation of GRID1 intron

NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,144,964...10,891,946

G

Grid2 interacting protein

increases methylation

ISO

Methapyrilene results in increased methylation of GRID2IP intron

NCBI chr12:16,274,809...16,317,319
Ensembl chr12:16,280,168...16,317,278

G

glutamate ionotropic receptor kainate type subunit 1

increases methylation

ISO

Methapyrilene results in increased methylation of GRIK1 intron

NCBI chr11:40,655,974...41,056,966
Ensembl chr11:40,655,975...41,056,517

G

glutamate ionotropic receptor kainate type subunit 4

affects methylation

ISO

Methapyrilene affects the methylation of GRIK4 intron

NCBI chr 8:51,802,045...52,228,751
Ensembl chr 8:51,802,058...52,102,063

G

glutamate ionotropic receptor kainate type subunit 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of GRIK5 intron

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962

G

glutamate ionotropic receptor NMDA type subunit 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GRIN1 intron

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

increases methylation

ISO

Methapyrilene results in increased methylation of GRIN2A intron

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

increases methylation

ISO

Methapyrilene results in increased methylation of GRIN2B intron

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate receptor interacting protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of GRIP2 intron

NCBI chr 4:125,828,609...125,913,693
Ensembl chr 4:125,828,609...125,913,750

G

G protein-coupled receptor kinase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of GRK1 intron

NCBI chr16:82,821,184...82,837,971
Ensembl chr16:82,826,022...82,837,971

G

G protein-coupled receptor kinase 5

increases methylation

ISO

Methapyrilene results in increased methylation of GRK5 intron

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

G protein-coupled receptor kinase 6

decreases expression

EXP

Methapyrilene results in decreased expression of GRK6 mRNA

NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954

G

glutamate metabotropic receptor 4

increases methylation

ISO

Methapyrilene results in increased methylation of GRM4 intron

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,482,977...5,574,668

G

glutamate metabotropic receptor 5

increases methylation

ISO

Methapyrilene results in increased methylation of GRM5 intron

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649

G

GrpE-like 1, mitochondrial

increases expression

EXP

Methapyrilene results in increased expression of GRPEL1 mRNA

NCBI chr14:78,517,049...78,522,868
Ensembl chr14:78,517,052...78,522,861

G

goosecoid homeobox

increases methylation

ISO

Methapyrilene results in increased methylation of GSC polyA tail

NCBI chr 6:129,152,836...129,154,875
Ensembl chr 6:129,152,836...129,154,875

G

gasdermin A

increases methylation

ISO

Methapyrilene results in increased methylation of GSDMA intron

NCBI chr10:84,110,590...84,135,804
Ensembl chr10:84,123,314...84,135,804

G

gasdermin D

decreases methylation

ISO

Methapyrilene results in decreased methylation of GSDMD intron

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

GSG1-like

increases methylation

ISO

Methapyrilene results in increased methylation of GSG1L intron

NCBI chr 1:189,871,034...190,084,947
Ensembl chr 1:189,871,034...190,084,947

G

glycogen synthase kinase 3 beta

increases expression

EXP

Methapyrilene results in increased expression of GSK3B mRNA

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

increases expression

EXP

Methapyrilene results in increased expression of GSR mRNA

PMID:15890375 PMID:28935588

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione synthetase

increases expression

EXP

Methapyrilene results in increased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306

G

glutathione S-transferase alpha 2

increases expression

EXP

Methapyrilene results in increased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 4

increases expression

EXP

Methapyrilene results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase alpha 5

increases expression

EXP

Methapyrilene results in increased expression of GSTA5 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 2

decreases expression

EXP

Methapyrilene results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

increases expression

EXP

Methapyrilene results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase, theta 3

decreases expression

EXP

Methapyrilene results in decreased expression of GSTT3 mRNA

NCBI chr20:12,873,618...12,881,974
Ensembl chr20:12,874,374...12,881,973

G

general transcription factor 2A subunit 1 like

increases methylation

ISO

Methapyrilene results in increased methylation of GTF2A1L intron

NCBI chr 6:11,506,362...11,591,622
Ensembl chr 6:11,506,363...11,565,862

G

general transcription factor II I

decreases expression

EXP

Methapyrilene results in decreased expression of GTF2I mRNA

NCBI chr12:28,037,344...28,112,677
Ensembl chr12:28,037,853...28,112,677

G

GTF2I repeat domain containing 1

affects methylation

ISO

Methapyrilene affects the methylation of GTF2IRD1 intron

NCBI chr12:27,890,594...27,997,506
Ensembl chr12:27,890,675...27,997,494

G

general transcription factor IIIC subunit 2

decreases expression

EXP

Methapyrilene results in decreased expression of GTF3C2 mRNA

NCBI chr 6:30,913,263...30,941,305
Ensembl chr 6:30,923,106...30,940,465

G

general transcription factor IIIC subunit 3

decreases expression

EXP

Methapyrilene results in decreased expression of GTF3C3 mRNA

NCBI chr 9:63,375,860...63,437,475
Ensembl chr 9:63,375,874...63,437,413

G

GTP binding protein 10

decreases expression

EXP

Methapyrilene results in decreased expression of GTPBP10 mRNA

NCBI chr 4:29,431,683...29,449,201
Ensembl chr 4:29,431,692...29,449,212

G

GTP binding protein 2

decreases expression

EXP

Methapyrilene results in decreased expression of GTPBP2 mRNA

NCBI chr 9:22,311,532...22,321,405
Ensembl chr 9:22,311,158...22,321,441

G

G-2 and S-phase expressed 1

increases expression

EXP

Methapyrilene results in increased expression of GTSE1 mRNA

NCBI chr 7:118,829,793...118,846,662
Ensembl chr 7:118,829,903...118,846,661

G

guanylate cyclase 1 soluble subunit alpha 2

increases methylation

ISO

Methapyrilene results in increased methylation of GUCY1A2 intron

NCBI chr 8:8,785,212...9,174,322
Ensembl chr 8:8,785,121...9,174,272

G

guanylate cyclase 2C

decreases methylation

ISO

Methapyrilene results in decreased methylation of GUCY2C intron

NCBI chr 4:171,299,715...171,380,296
Ensembl chr 4:171,299,740...171,380,296

G

guanylate cyclase 2E

increases methylation

ISO

Methapyrilene results in increased methylation of GUCY2D intron

NCBI chr10:54,453,753...54,478,639
Ensembl chr10:54,457,844...54,472,898

G

gulonolactone (L-) oxidase

decreases expression

EXP

Methapyrilene results in decreased expression of GULO mRNA

NCBI chr15:44,381,226...44,403,314
Ensembl chr15:44,381,214...44,403,422

G

glycogen synthase 2

decreases expression

EXP

Methapyrilene results in decreased expression of GYS2 mRNA

PMID:16393664 PMID:30467583

NCBI chr 4:177,096,063...177,137,236
Ensembl chr 4:177,096,063...177,137,236

G

H1.0 linker histone

decreases expression

EXP

Methapyrilene results in decreased expression of H1F0 mRNA

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:112,473,222...112,475,006

G

H2A.X variant histone

increases methylation
increases expression

ISO
EXP

Methapyrilene results in increased methylation of H2AX polyA tail
Methapyrilene results in increased expression of H2AX mRNA

PMID:15890375 PMID:30157460

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H2A.Z variant histone 1

increases expression

EXP

Methapyrilene results in increased expression of H2AZ1 mRNA

NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:229,028,843...229,031,411

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of H6PD mRNA
Methapyrilene results in increased methylation of H6PD intron

PMID:30157460 PMID:30467583

NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125

G

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

decreases expression

EXP

Methapyrilene results in decreased expression of HACE1 mRNA

NCBI chr20:50,618,004...50,733,460
Ensembl chr20:50,618,004...50,733,466

G

2-hydroxyacyl-CoA lyase 1

decreases expression

EXP

Methapyrilene results in decreased expression of HACL1 mRNA

NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,833,268...6,869,410

G

hydroxyacyl-CoA dehydrogenase

decreases expression

EXP

Methapyrilene results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

EXP

Methapyrilene results in decreased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

histidine ammonia lyase

decreases expression

EXP

Methapyrilene results in decreased expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hepcidin antimicrobial peptide

increases expression

ISO

Methapyrilene results in increased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hydroxyacid oxidase 2

decreases expression

ISO
EXP

Methapyrilene results in decreased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

HAUS augmin-like complex, subunit 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of HAUS7 intron

NCBI chr X:156,306,320...156,331,940
Ensembl chr X:156,306,320...156,352,158

G

HAUS augmin-like complex, subunit 8

increases methylation

ISO

Methapyrilene results in increased methylation of HAUS8 intron

NCBI chr16:17,964,813...17,979,313
Ensembl chr16:17,964,814...17,979,192

G

host cell factor C2

decreases expression

EXP

Methapyrilene results in decreased expression of HCFC2 mRNA

NCBI chr 7:22,875,440...22,907,391
Ensembl chr 7:22,864,278...22,907,322

G

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

affects methylation

ISO

Methapyrilene affects the methylation of HCN4 intron

NCBI chr 8:68,118,062...68,155,482
Ensembl chr 8:68,118,062...68,155,495

G

histone deacetylase 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of HDAC4 intron

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637

G

histone deacetylase 9

decreases methylation

ISO

Methapyrilene results in decreased methylation of HDAC9 intron

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835

G

histidine decarboxylase

increases expression

EXP

Methapyrilene results in increased expression of HDC mRNA

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

HD domain containing 3

decreases expression

EXP

Methapyrilene results in decreased expression of HDDC3 mRNA

NCBI chr 1:143,708,703...143,711,010
Ensembl chr 1:143,705,320...143,711,010

G

haloacid dehalogenase-like hydrolase domain containing 3

decreases expression

EXP

Methapyrilene results in decreased expression of HDHD3 mRNA

NCBI chr 5:80,966,878...80,970,345
Ensembl chr 5:80,954,610...80,970,854

G

HEAT repeat containing 5B

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of HEATR5B mRNA
Methapyrilene results in increased methylation of HEATR5B exon

PMID:30157460 PMID:30467583

NCBI chr 6:21,995,558...22,075,582
Ensembl chr 6:21,995,602...22,075,582

G

HECT domain E3 ubiquitin protein ligase 1

decreases expression

EXP

Methapyrilene results in decreased expression of HECTD1 mRNA

NCBI chr 6:74,916,803...75,003,408
Ensembl chr 6:74,916,803...75,003,408

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of HECW1 intron

NCBI chr17:55,366,904...55,780,028
Ensembl chr17:55,366,657...55,776,212

G

helicase with zinc finger

increases methylation

ISO

Methapyrilene results in increased methylation of HELZ intron

NCBI chr10:92,979,039...93,144,868
Ensembl chr10:92,999,733...93,138,075

G

helicase with zinc finger 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of HELZ2 promoter

NCBI chr 3:188,716,370...188,730,776
Ensembl chr 3:188,716,370...188,730,716

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of HERC3 exon

NCBI chr 4:89,282,374...89,372,656
Ensembl chr 4:89,282,445...89,372,652

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

EXP

Methapyrilene results in decreased expression of HERC6 mRNA

NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993

G

homocysteine inducible ER protein with ubiquitin like domain 1

decreases expression

EXP

Methapyrilene results in decreased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

HEXIM P-TEFb complex subunit 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of HEXIM2 intron

NCBI chr10:88,572,102...88,584,856
Ensembl chr10:88,578,996...88,584,855

G

hepatocyte growth factor

decreases methylation

ISO

Methapyrilene results in decreased methylation of HGF intron

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

3-hydroxyisobutyrate dehydrogenase

decreases expression

EXP

Methapyrilene results in decreased expression of HIBADH mRNA

NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:82,979,765...83,111,242

G

3-hydroxyisobutyryl-CoA hydrolase

decreases expression

EXP

Methapyrilene results in decreased expression of HIBCH mRNA; Methapyrilene results in decreased expression of HIBCH protein

NCBI chr 9:56,082,082...56,161,796
Ensembl chr 9:56,082,091...56,161,886

G

hypoxia inducible factor 1 subunit alpha

decreases expression

EXP

Methapyrilene results in decreased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

EXP

Methapyrilene results in increased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

histidine triad nucleotide binding protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:28,854,844...28,867,125

G

huntingtin interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of HIP1 intron

NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296

G

homeodomain interacting protein kinase 1

decreases expression

EXP

Methapyrilene results in decreased expression of HIPK1 mRNA

NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164

G

homeodomain interacting protein kinase 2

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of HIPK2 mRNA
Methapyrilene results in decreased methylation of HIPK2 intron

PMID:30157460 PMID:30467583

NCBI chr 4:68,399,358...68,586,404
Ensembl chr 4:68,369,099...68,586,108

G

HIRA interacting protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of HIRIP3 mRNA

NCBI chr 1:190,903,065...190,905,610
Ensembl chr 1:190,902,593...190,905,607

G

HIVEP zinc finger 3

increases methylation

ISO

Methapyrilene results in increased methylation of HIVEP3 intron

NCBI chr 5:138,610,592...139,013,058
Ensembl chr 5:138,943,312...139,010,430

G

hemojuvelin BMP co-receptor

decreases expression

EXP

Methapyrilene results in decreased expression of HJV mRNA

NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:186,754,811...186,758,867

G

hexokinase 1

affects expression

EXP

Methapyrilene affects the expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

hexokinase 3

decreases expression

EXP

Methapyrilene results in decreased expression of HK3 mRNA

NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,605,016...9,620,037

G

holocarboxylase synthetase

decreases methylation
decreases expression

ISO
EXP

Methapyrilene results in decreased methylation of HLCS intron
Methapyrilene results in decreased expression of HLCS mRNA

PMID:30157460 PMID:30467583

NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082

G

histocompatibility minor 13

decreases methylation

ISO

Methapyrilene results in decreased methylation of HM13 intron

NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:161,606,052...161,644,805

G

hydroxymethylbilane synthase

decreases expression

EXP

Methapyrilene results in decreased expression of HMBS mRNA

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

hemicentin 1

increases methylation

ISO

Methapyrilene results in increased methylation of HMCN1 intron

NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519

G

hemicentin 2

increases methylation

ISO

Methapyrilene results in increased methylation of HMCN2 intron

NCBI chr 3:34,986,246...35,136,047
Ensembl chr 3:34,986,263...35,136,106

G

high mobility group box 2

increases expression

EXP

Methapyrilene results in increased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression
increases expression

EXP

Methapyrilene results in decreased expression of HMGCS2 mRNA
Methapyrilene results in increased expression of HMGCS2 protein

PMID:16393664 PMID:30467583

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

heme oxygenase 1

increases expression

EXP

Methapyrilene results in increased expression of HMOX1 mRNA; Methapyrilene results in increased expression of HMOX1 protein

PMID:15890375 PMID:16393664 PMID:19523481

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of HMOX2 intron

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

H6 family homeobox 1

increases methylation

ISO

Methapyrilene results in increased methylation of HMX1 intron; Methapyrilene results in increased methylation of HMX1 polyA tail

NCBI chr14:79,585,840...79,589,626
Ensembl chr14:79,585,840...79,589,626

G

HNF1 homeobox A

decreases expression

EXP

Methapyrilene results in decreased expression of HNF1A mRNA

NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755

G

hepatocyte nuclear factor 4, alpha

multiple interactions
decreases expression

ISO
EXP

Methapyrilene inhibits the reaction [HNF4A protein binds to TF promoter]
Methapyrilene results in decreased expression of HNF4A mRNA
Methapyrilene results in decreased expression of HNF4A protein

PMID:28935588 PMID:30467583

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heterogeneous nuclear ribonucleoprotein A0

decreases expression

EXP

Methapyrilene results in decreased expression of HNRNPA0 mRNA

NCBI chr17:6,513,129...6,515,786
Ensembl chr17:6,512,629...6,516,127

G

heterogeneous nuclear ribonucleoprotein A3

decreases expression

EXP

Methapyrilene results in decreased expression of HNRNPA3 mRNA

NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:80,985,969...80,996,043

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

EXP

Methapyrilene results in decreased expression of HNRNPK mRNA

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

heterogeneous nuclear ribonucleoprotein M

decreases methylation

ISO

Methapyrilene results in decreased methylation of HNRNPM polyA tail

NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:15,129,287...15,178,871

G

heterogeneous nuclear ribonucleoprotein R

decreases expression

EXP

Methapyrilene results in decreased expression of HNRNPR mRNA

NCBI chr 5:153,826,482...153,872,272
Ensembl chr 5:153,826,692...153,858,344

G

heterogeneous nuclear ribonucleoprotein U

decreases expression

EXP

Methapyrilene results in decreased expression of HNRNPU mRNA

NCBI chr13:92,609,791...92,618,580
Ensembl chr13:92,605,216...92,618,612

G

hook microtubule-tethering protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of HOOK2 intron

NCBI chr19:40,056,732...40,075,027
Ensembl chr19:40,056,732...40,081,270

G

hook microtubule-tethering protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of HOOK3 mRNA

NCBI chr16:72,656,929...72,751,696
Ensembl chr16:72,657,019...72,764,071

G

homeo box C12

increases methylation

ISO

Methapyrilene results in increased methylation of HOXC12 exon

NCBI chr 7:135,952,682...135,954,280
Ensembl chr 7:135,952,682...135,954,280

G

heterochromatin protein 1, binding protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of HP1BP3 mRNA

NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:155,719,115...155,746,325

G

hippocalcin-like 1

increases methylation

ISO

Methapyrilene results in increased methylation of HPCAL1 intron

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

4-hydroxyphenylpyruvate dioxygenase

decreases methylation

ISO

Methapyrilene results in decreased methylation of HPD intron

NCBI chr12:39,042,246...39,053,596
Ensembl chr12:39,042,238...39,053,612

G

hepsin

decreases expression

EXP

Methapyrilene results in decreased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199

G

hypoxanthine phosphoribosyltransferase 1

increases expression

EXP

Methapyrilene results in increased expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

heparanase 2 (inactive)

increases methylation

ISO

Methapyrilene results in increased methylation of HPSE2 intron

NCBI chr 1:251,532,149...252,231,316
Ensembl chr 1:251,532,149...252,195,255

G

HRas proto-oncogene, GTPase

increases expression

EXP

Methapyrilene results in increased expression of HRAS mRNA

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

heparan sulfate-glucosamine 3-sulfotransferase 3B1

decreases methylation

ISO

Methapyrilene results in decreased methylation of HS3ST3B1 intron

NCBI chr10:49,060,693...49,093,185
Ensembl chr10:49,060,693...49,093,185

G

heparan sulfate 6-O-sulfotransferase 1

increases methylation

ISO

Methapyrilene results in increased methylation of HS6ST1 intron

NCBI chr 9:45,779,402...45,818,583
Ensembl chr 9:45,779,019...45,818,582

G

hydroxysteroid (17-beta) dehydrogenase 14

increases methylation

ISO

Methapyrilene results in increased methylation of HSD17B14 intron

NCBI chr 1:105,165,695...105,176,045
Ensembl chr 1:105,165,695...105,176,510

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

EXP

Methapyrilene results in decreased expression of HSD17B4 mRNA

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

hydroxysteroid (17-beta) dehydrogenase 6

increases methylation

ISO

Methapyrilene results in increased methylation of HSD17B6 intron

NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5

decreases expression

EXP

Methapyrilene results in decreased expression of HSD3B5 mRNA

NCBI chr 2:188,697,669...188,717,141
Ensembl chr 2:188,697,670...188,709,118

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of HSD3B7 intron
Methapyrilene results in decreased expression of HSD3B7 mRNA

PMID:30157460 PMID:30467583

NCBI chr 1:191,842,688...191,845,919
Ensembl chr 1:191,842,636...191,845,921

G

heat shock transcription factor 1

increases expression

EXP

Methapyrilene results in increased expression of HSF1 mRNA

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

hematopoietic SH2 domain containing

decreases methylation

ISO

Methapyrilene results in decreased methylation of HSH2D polyA tail

NCBI chr16:17,664,548...17,686,976
Ensembl chr16:17,669,345...17,682,013

G

heat shock protein 90 beta family member 1

decreases expression

EXP

Methapyrilene results in decreased expression of HSP90B1 mRNA

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 12A

decreases methylation

ISO

Methapyrilene results in decreased methylation of HSPA12A intron

NCBI chr 1:267,921,780...268,083,171
Ensembl chr 1:267,921,782...268,082,794

G

heat shock protein family A (Hsp70) member 13

decreases expression

EXP

Methapyrilene results in decreased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898

G

heat shock protein family A (Hsp70) member 5

increases expression

EXP

Methapyrilene results in increased expression of HSPA5 mRNA

PMID:15120968 PMID:17450226

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

increases expression

EXP

Methapyrilene results in increased expression of HSPA8 protein

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family A (Hsp70) member 9

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of HSPA9 mRNA
Methapyrilene results in decreased expression of HSPA9 protein

PMID:15890375 PMID:17450226 PMID:22484513 PMID:30467583

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

heat shock protein family B (small) member 1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of HSPB1 mRNA
Methapyrilene results in decreased expression of HSPB1 mRNA

PMID:15890375 PMID:16393664 PMID:30467583

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

increases expression

EXP

Methapyrilene results in increased expression of HSPD1 protein

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

increases expression

EXP

Methapyrilene results in increased expression of HSPE1 mRNA

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

heat shock protein family H (Hsp110) member 1

increases expression

EXP

Methapyrilene results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

HtrA serine peptidase 3

increases methylation

ISO

Methapyrilene results in increased methylation of HTRA3 intron

NCBI chr14:79,293,535...79,321,936
Ensembl chr14:79,293,541...79,321,936

G

hormonally upregulated Neu-associated kinase

decreases methylation

ISO

Methapyrilene results in decreased methylation of HUNK promoter

NCBI chr11:43,127,244...43,244,502
Ensembl chr11:43,127,244...43,244,502

G

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of HUWE1 exon

NCBI chr X:24,350,708...24,480,798
Ensembl chr X:24,353,217...24,480,798

G

hyccin PI4KA lipid kinase complex subunit 2

decreases expression

EXP

Methapyrilene results in decreased expression of HYCC2 mRNA

NCBI chr 9:67,551,064...67,623,353
Ensembl chr 9:67,551,064...67,587,186

G

Hydin, axonemal central pair apparatus protein

affects methylation

ISO

Methapyrilene affects the methylation of HYDIN intron

NCBI chr19:55,146,382...55,492,660
Ensembl chr19:55,146,466...55,492,660

G

isoleucyl-tRNA synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of IARS1 mRNA

NCBI chr17:15,147,357...15,193,716
Ensembl chr17:15,147,357...15,193,652

G

inhibitor of Bruton tyrosine kinase

decreases expression

EXP

Methapyrilene results in decreased expression of IBTK mRNA

NCBI chr 8:95,505,630...95,579,435
Ensembl chr 8:95,505,630...95,578,301

G

intercellular adhesion molecule 1

increases expression

EXP
ISO

Methapyrilene results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

intercellular adhesion molecule 2

increases methylation

ISO

Methapyrilene results in increased methylation of ICAM2 polyA tail

NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,808,316...91,815,072

G

insulin degrading enzyme

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of IDE mRNA
Methapyrilene results in decreased expression of IDE mRNA

PMID:15890375 PMID:30467583

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

EXP

Methapyrilene results in decreased expression of IDH2 mRNA

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

increases methylation

ISO

Methapyrilene results in increased methylation of IDH3G polyA tail

NCBI chr X:156,666,573...156,675,482
Ensembl chr X:156,666,577...156,675,799

G

isopentenyl-diphosphate delta isomerase 1

increases expression

EXP

Methapyrilene results in increased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

iduronate 2-sulfatase

decreases expression

EXP

Methapyrilene results in decreased expression of IDS mRNA

NCBI chr X:154,070,781...154,093,681
Ensembl chr X:154,070,781...154,091,444

G

immediate early response 3 interacting protein 1, pseudogene 1

increases methylation

ISO

Methapyrilene results in increased methylation of IER3IP1 promoter

NCBI chr 4:133,898,662...133,899,156
Ensembl chr 4:133,887,903...133,898,847

G

immediate early response 5

increases expression

EXP

Methapyrilene results in increased expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

IFI30, lysosomal thiol reductase

decreases methylation

ISO

Methapyrilene results in decreased methylation of IFI30 intron

NCBI chr16:18,709,570...18,713,635
Ensembl chr16:18,709,563...18,715,711

G

interferon-induced protein 35

decreases expression

EXP

Methapyrilene results in decreased expression of IFI35 mRNA

NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

EXP

Methapyrilene results in decreased expression of IFIT2 mRNA

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:241,515,709...241,521,798

G

interferon induced transmembrane protein 1

increases expression

EXP

Methapyrilene results in increased expression of IFITM1 mRNA

NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776

G

interferon alpha and beta receptor subunit 1

decreases expression

EXP

Methapyrilene results in decreased expression of IFNAR1 mRNA

NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205

G

interferon gamma

increases expression

EXP

Methapyrilene results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 2

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of IFNGR2 intron
Methapyrilene results in decreased methylation of IFNGR2 promoter

NCBI chr11:44,265,703...44,283,975
Ensembl chr11:44,265,703...44,283,975

G

interferon-related developmental regulator 1

increases expression

EXP

Methapyrilene results in increased expression of IFRD1 mRNA

PMID:18619722 PMID:22484513

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

intraflagellar transport 140

increases methylation

ISO

Methapyrilene results in increased methylation of IFT140 intron

NCBI chr10:14,537,134...14,624,926
Ensembl chr10:14,537,466...14,624,926

G

intraflagellar transport 46

decreases expression

EXP

Methapyrilene results in decreased expression of IFT46 mRNA

NCBI chr 8:53,975,085...54,000,837
Ensembl chr 8:53,984,242...54,000,836

G

immunoglobulin superfamily, DCC subclass, member 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of IGDCC4 intron

NCBI chr 8:74,517,082...74,552,834
Ensembl chr 8:74,517,086...74,552,834

G

insulin-like growth factor 2 mRNA binding protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of IGF2BP3 intron

NCBI chr 4:79,391,367...79,525,923
Ensembl chr 4:79,393,067...79,525,730

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

EXP

Methapyrilene results in decreased expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 1

increases expression
decreases expression

EXP

Methapyrilene results in increased expression of IGFBP1 mRNA
Methapyrilene results in decreased expression of IGFBP1 mRNA

PMID:15120968 PMID:15890375 PMID:30467583

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of IGFBP2 intron

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

immunoglobulin-like and fibronectin type III domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of IGFN1 intron

NCBI chr13:49,947,330...49,979,203
Ensembl chr13:49,947,330...49,989,601

G

immunoglobulin superfamily, member 11

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of IGSF11 mRNA
Methapyrilene results in increased methylation of IGSF11 exon; Methapyrilene results in increased methylation of IGSF11 intron

PMID:30157460 PMID:30467583

NCBI chr11:75,238,706...75,389,748
Ensembl chr11:75,236,545...75,390,425

G

immunoglobin superfamily, member 21

decreases methylation

ISO

Methapyrilene results in decreased methylation of IGSF21 intron

NCBI chr 5:157,570,964...157,795,290
Ensembl chr 5:157,570,964...157,795,290

G

immunoglobulin superfamily, member 9

decreases methylation

ISO

Methapyrilene results in decreased methylation of IGSF9 exon; Methapyrilene results in decreased methylation of IGSF9 promoter

NCBI chr13:87,480,979...87,497,974
Ensembl chr13:87,481,279...87,497,974

G

immunoglobulin superfamily, member 9B

increases methylation

ISO

Methapyrilene results in increased methylation of IGSF9B intron

NCBI chr 8:33,971,779...34,027,390
Ensembl chr 8:33,971,779...34,018,128

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of IKBKB mRNA
Methapyrilene results in decreased methylation of IKBKB intron

PMID:30157460 PMID:30467583

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

decreases expression

EXP

Methapyrilene results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 10 receptor subunit alpha

increases methylation

ISO

Methapyrilene results in increased methylation of IL10RA intron

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028

G

interleukin 12B

increases expression

EXP

Methapyrilene results in increased expression of IL12B protein

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 12 receptor subunit beta 1

increases methylation

ISO

Methapyrilene results in increased methylation of IL12RB1 promoter

NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,654,207...18,666,824

G

interleukin 17 receptor D

increases methylation

ISO

Methapyrilene results in increased methylation of IL17RD intron

NCBI chr16:2,235,172...2,489,827
Ensembl chr16:2,235,169...2,301,850

G

interleukin 18 receptor 1

increases methylation

ISO

Methapyrilene results in increased methylation of IL18R1 intron

NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:50,223,200...50,257,367

G

interleukin 1 alpha

increases expression

EXP

Methapyrilene results in increased expression of IL1A protein

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

EXP

Methapyrilene results in increased expression of IL1B mRNA; Methapyrilene results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor accessory protein

increases methylation

ISO

Methapyrilene results in increased methylation of IL1RAP intron

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342

G

interleukin 1 receptor accessory protein-like 1

increases methylation

ISO

Methapyrilene results in increased methylation of IL1RAPL1 intron

NCBI chr X:55,322,779...56,827,486
Ensembl chr X:55,328,964...56,826,613

G

interleukin 1 receptor-like 1

decreases expression

EXP

Methapyrilene results in decreased expression of IL1RL1 protein

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 1 receptor antagonist

increases expression

EXP

Methapyrilene results in increased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 2 receptor subunit beta

increases methylation

ISO

Methapyrilene results in increased methylation of IL2RB 3' UTR

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537

G

interleukin 4 induced 1

increases methylation

ISO

Methapyrilene results in increased methylation of IL4I1 intron

NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:104,435,981...104,461,053

G

interleukin 4 receptor

increases methylation

ISO

Methapyrilene results in increased methylation of IL4R intron

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 6

decreases expression

EXP

Methapyrilene results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases methylation

ISO

Methapyrilene results in increased methylation of IL6R intron

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

decreases expression

EXP

Methapyrilene results in decreased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

interleukin 7

decreases expression

ISO

Methapyrilene results in decreased expression of IL7 mRNA

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

ilvB acetolactate synthase like

decreases methylation

ISO

Methapyrilene results in decreased methylation of HACL2 intron

NCBI chr 7:11,690,445...11,700,498
Ensembl chr 7:11,690,445...11,700,498

G

inner mitochondrial membrane peptidase subunit 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of IMMP2L intron

NCBI chr 6:63,797,189...64,696,906
Ensembl chr 6:63,797,237...64,697,749

G

inhibitor of growth family, member 1

increases expression

EXP

Methapyrilene results in increased expression of ING1 mRNA

NCBI chr16:84,639,378...84,649,498
Ensembl chr16:84,639,381...84,647,616

G

inhibin subunit beta E

decreases expression

EXP

Methapyrilene results in decreased expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

inositol polyphosphate-4-phosphatase type I A

increases methylation

ISO

Methapyrilene results in increased methylation of INPP4A intron

NCBI chr 9:47,024,064...47,142,391
Ensembl chr 9:47,087,471...47,135,968

G

inositol polyphosphate-5-phosphatase A

affects methylation

ISO

Methapyrilene affects the methylation of INPP5A intron

NCBI chr 1:203,619,676...203,810,035
Ensembl chr 1:203,619,637...203,810,028

G

inositol polyphosphate-5-phosphatase D

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of INPP5D intron
Methapyrilene results in decreased methylation of INPP5D exon

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

insulin induced gene 2

decreases expression

EXP

Methapyrilene results in decreased expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

insulin receptor

affects methylation
decreases expression
decreases methylation

ISO
EXP

Methapyrilene affects the methylation of INSR intron
Methapyrilene results in decreased expression of INSR mRNA
Methapyrilene results in decreased methylation of INSR exon

PMID:30157460 PMID:30467583

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

inhibitory synaptic factor family member 2B

increases methylation

ISO

Methapyrilene results in increased methylation of INSYN2B intron

NCBI chr10:19,420,561...19,528,006
Ensembl chr10:19,507,084...19,511,298

G

integrator complex subunit 6

increases expression

EXP

Methapyrilene results in increased expression of INTS6 mRNA

NCBI chr15:41,080,584...41,224,350
Ensembl chr15:41,109,125...41,197,519

G

integrator complex subunit 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of INTS7 intron

NCBI chr13:105,686,208...105,739,609
Ensembl chr13:105,686,128...105,739,608

G

integrator complex subunit 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of INTS8 intron

NCBI chr 5:29,094,475...29,141,874
Ensembl chr 5:29,094,475...29,142,099

G

integrator complex subunit 9

increases methylation

ISO

Methapyrilene results in increased methylation of INTS9 intron

NCBI chr15:43,376,235...43,460,549
Ensembl chr15:43,375,850...43,478,936

G

importin 4

increases expression
decreases methylation

EXP
ISO

Methapyrilene results in increased expression of IPO4 mRNA
Methapyrilene results in decreased methylation of IPO4 promoter

PMID:28935588 PMID:30157460

NCBI chr15:33,087,321...33,097,241
Ensembl chr15:33,087,321...33,097,241

G

importin 7

increases methylation

ISO

Methapyrilene results in increased methylation of IPO7 promoter

NCBI chr 1:173,497,472...173,537,707
Ensembl chr 1:173,497,503...173,536,778

G

inositol-pentakisphosphate 2-kinase

increases methylation

ISO

Methapyrilene results in increased methylation of IPPK promoter

NCBI chr17:15,396,691...15,441,648
Ensembl chr17:15,395,168...15,436,000

G

IQ motif containing with AAA domain 1

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of DRC11 promoter
Methapyrilene results in decreased methylation of DRC11 intron

NCBI chr 9:98,074,389...98,190,233
Ensembl chr 9:98,073,887...98,190,066

G

IQ motif containing E

decreases methylation

ISO

Methapyrilene results in decreased methylation of IQCE intron

NCBI chr12:19,057,060...19,096,626
Ensembl chr12:19,056,307...19,096,624

G

IQ motif containing G

increases methylation

ISO

Methapyrilene results in increased methylation of DRC9 intron

NCBI chr11:81,235,204...81,276,249
Ensembl chr11:81,235,090...81,276,249

G

IQ motif containing GTPase activating protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of IQGAP3 intron

NCBI chr 2:175,840,001...175,881,799
Ensembl chr 2:175,839,949...175,881,797

G

IQ motif and Sec7 domain ArfGEF 1

increases methylation

ISO

Methapyrilene results in increased methylation of IQSEC1 intron

NCBI chr 4:124,725,917...125,045,351
Ensembl chr 4:124,725,917...125,045,550

G

IQ motif and Sec7 domain ArfGEF 3

increases methylation

ISO

Methapyrilene results in increased methylation of IQSEC3 exon

NCBI chr 4:156,283,040...156,379,396
Ensembl chr 4:156,283,043...156,379,396

G

iron responsive element binding protein 2

affects expression
decreases expression

ISO
EXP

Methapyrilene affects the expression of IREB2 mRNA
Methapyrilene results in decreased expression of IREB2 mRNA

PMID:28935588 PMID:30467583

NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520

G

interferon regulatory factor 2

increases methylation

ISO

Methapyrilene results in increased methylation of IRF2 intron

NCBI chr16:52,171,855...52,283,620
Ensembl chr16:52,164,442...52,282,627

G

interferon regulatory factor 2 binding protein-like

decreases expression

EXP

Methapyrilene results in decreased expression of IRF2BPL mRNA

NCBI chr 6:112,258,149...112,262,264
Ensembl chr 6:112,258,188...112,263,280

G

interferon regulatory factor 3

increases methylation

ISO

Methapyrilene results in increased methylation of IRF3 promoter

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

interferon regulatory factor 9

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of IRF9 mRNA
Methapyrilene results in decreased methylation of IRF9 exon

PMID:30157460 PMID:30467583

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879

G

immunity related GTPase cinema

decreases methylation

ISO

Methapyrilene results in decreased methylation of IRGC promoter

NCBI chr 1:89,148,056...89,151,838
Ensembl chr 1:89,147,624...89,153,921

G

insulin receptor substrate 2

decreases expression

EXP

Methapyrilene results in decreased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

immunoglobulin superfamily containing leucine-rich repeat 2

increases methylation

ISO

Methapyrilene results in increased methylation of ISLR2 intron

NCBI chr 8:67,504,042...67,512,125
Ensembl chr 8:67,504,037...67,513,708

G

isthmin 1

increases methylation

ISO

Methapyrilene results in increased methylation of ISM1 intron

NCBI chr 3:147,476,983...147,555,900
Ensembl chr 3:147,475,533...147,555,908

G

isthmin 2

increases methylation

ISO

Methapyrilene results in increased methylation of ISM2 intron

NCBI chr 6:112,652,772...112,675,098
Ensembl chr 6:112,657,122...112,675,295

G

isochorismatase domain containing 2b

increases methylation

ISO

Methapyrilene results in increased methylation of ISOC2 intron

NCBI chr 1:78,001,735...78,022,565
Ensembl chr 1:78,001,735...78,022,564

G

integrin subunit alpha 11

decreases methylation

ISO

Methapyrilene results in decreased methylation of ITGA11 intron

NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137

G

integrin subunit alpha 2b

increases methylation

ISO

Methapyrilene results in increased methylation of ITGA2B intron

NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833

G

integrin subunit alpha 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of ITGA3 intron

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901

G

integrin subunit alpha 5

increases methylation

ISO

Methapyrilene results in increased methylation of ITGA5 intron

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305

G

integrin subunit alpha 6

increases methylation

ISO

Methapyrilene results in increased methylation of ITGA6 intron

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

integrin subunit alpha 9

increases methylation

ISO

Methapyrilene results in increased methylation of ITGA9 intron

NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296

G

integrin subunit alpha D

increases methylation

ISO

Methapyrilene results in increased methylation of ITGAD intron

NCBI chr 1:192,190,204...192,218,864
Ensembl chr 1:192,190,204...192,218,864

G

integrin subunit alpha E

decreases methylation

ISO

Methapyrilene results in decreased methylation of ITGAE intron

NCBI chr10:58,203,331...58,262,606
Ensembl chr10:58,203,364...58,262,606

G

inter-alpha-trypsin inhibitor heavy chain 4

increases expression

EXP

Methapyrilene results in increased expression of ITIH4 mRNA

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

inter-alpha-trypsin inhibitor heavy chain 5

increases methylation

ISO

Methapyrilene results in increased methylation of ITIH5 polyA tail

NCBI chr17:73,161,886...73,261,930
Ensembl chr17:73,161,611...73,262,496

G

IL2-inducible T-cell kinase

increases methylation

EXP

Methapyrilene results in increased methylation of ITK gene

NCBI chr10:31,254,667...31,316,004
Ensembl chr10:31,254,667...31,316,004

G

inositol-tetrakisphosphate 1-kinase

affects methylation

ISO

Methapyrilene affects the methylation of ITPK1 intron

NCBI chr 6:127,475,589...127,609,320
Ensembl chr 6:127,476,808...127,609,062

G

inositol-trisphosphate 3-kinase A

increases methylation

ISO

Methapyrilene results in increased methylation of ITPKA polyA tail

NCBI chr 3:127,179,841...127,188,405
Ensembl chr 3:127,179,808...127,188,414

G

inositol-trisphosphate 3-kinase B

increases methylation

ISO

Methapyrilene results in increased methylation of ITPKB exon

NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

EXP

Methapyrilene results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

inositol 1,4,5-trisphosphate receptor, type 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of ITPR2 intron

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763

G

intersectin 1

increases methylation

ISO

Methapyrilene results in increased methylation of ITSN1 intron

NCBI chr11:44,464,515...44,646,598
Ensembl chr11:44,513,186...44,646,598

G

intersectin 2

decreases expression

EXP

Methapyrilene results in decreased expression of ITSN2 mRNA

NCBI chr 6:33,336,086...33,446,818
Ensembl chr 6:33,336,441...33,446,818

G

isovaleryl-CoA dehydrogenase

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of IVD mRNA
Methapyrilene results in increased methylation of IVD intron

PMID:30157460 PMID:30467583

NCBI chr 3:126,305,584...126,326,016
Ensembl chr 3:126,305,364...126,328,160

G

interacts with SUPT6H, CTD assembly factor 1

decreases expression

EXP

Methapyrilene results in decreased expression of IWS1 mRNA

NCBI chr18:23,969,352...24,011,560
Ensembl chr18:23,969,733...24,010,415

G

jade family PHD finger 1

decreases expression

EXP

Methapyrilene results in decreased expression of JADE1 mRNA

NCBI chr 2:126,471,124...126,524,252
Ensembl chr 2:126,471,124...126,524,252

G

Janus kinase 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of JAK3 exon

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222

G

janus kinase and microtubule interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of JAKMIP1 intron

NCBI chr14:77,871,034...77,991,566
Ensembl chr14:77,871,034...77,991,525

G

janus kinase and microtubule interacting protein 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of JAKMIP3 intron

NCBI chr 1:203,182,764...203,310,714
Ensembl chr 1:203,241,125...203,310,713

G

junctional adhesion molecule 3

increases methylation

ISO

Methapyrilene results in increased methylation of JAM3 intron

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

jumonji and AT-rich interaction domain containing 2

affects methylation

ISO

Methapyrilene affects the methylation of JARID2 intron

NCBI chr17:19,983,217...20,163,598
Ensembl chr17:19,983,217...20,161,970

G

Jun dimerization protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of JDP2 intron

NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:110,992,806...111,033,392

G

junctional cadherin complex regulator

increases methylation

ISO

Methapyrilene results in increased methylation of JHY exon; Methapyrilene results in increased methylation of JHY intron

NCBI chr 8:50,173,602...50,230,429
Ensembl chr 8:50,173,123...50,230,542

G

junctophilin 2

increases methylation

ISO

Methapyrilene results in increased methylation of JPH2 intron

NCBI chr 3:172,414,246...172,478,678
Ensembl chr 3:172,414,256...172,478,348

G

junctophilin 3

affects methylation

ISO

Methapyrilene affects the methylation of JPH3 intron

NCBI chr19:66,702,497...66,763,948
Ensembl chr19:66,702,680...66,763,937

G

Jupiter microtubule associated homolog 1

increases expression

EXP

Methapyrilene results in increased expression of JPT1 mRNA

NCBI chr10:101,243,428...101,261,464
Ensembl chr10:101,243,424...101,261,469

G

Jupiter microtubule associated homolog 2

increases expression

EXP

Methapyrilene results in increased expression of JPT2 protein

NCBI chr10:14,467,652...14,487,769
Ensembl chr10:14,467,661...14,535,664

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Methapyrilene results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases methylation

ISO

Methapyrilene results in decreased methylation of JUND promoter

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

junction plakoglobin

increases methylation

ISO

Methapyrilene results in increased methylation of JUP exon

NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,800,814...85,827,429

G

kalirin, RhoGEF kinase

increases methylation

ISO

Methapyrilene results in increased methylation of KALRN intron

NCBI chr11:79,703,345...80,309,210
Ensembl chr11:79,703,366...80,133,329

G

KN motif and ankyrin repeat domains 1

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of KANK1 intron
Methapyrilene results in decreased methylation of KANK1 exon

NCBI chr 1:232,381,720...232,500,834
Ensembl chr 1:232,445,658...232,500,839

G

KN motif and ankyrin repeat domains 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of KANK4 intron

NCBI chr 5:118,516,994...118,581,024
Ensembl chr 5:118,517,971...118,581,002

G

lysine acetyltransferase 2B

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of KAT2B mRNA
Methapyrilene results in increased methylation of KAT2B intron

PMID:30157460 PMID:30467583

NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616

G

lysine acetyltransferase 6A

decreases expression

EXP

Methapyrilene results in decreased expression of KAT6A mRNA

NCBI chr16:75,787,411...75,868,584
Ensembl chr16:75,787,411...75,866,099

G

katanin catalytic subunit A1 like 2

decreases expression

ISO

Methapyrilene results in decreased expression of KATNAL2 mRNA

NCBI chr18:72,806,967...72,883,091
Ensembl chr18:72,806,900...72,883,256

G

kazrin, periplakin interacting protein

affects methylation

ISO

Methapyrilene affects the methylation of KAZN intron

NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:159,675,803...160,664,154

G

potassium voltage-gated channel subfamily A member 2

increases methylation

ISO

Methapyrilene results in increased methylation of KCNA2 exon

NCBI chr 2:197,392,746...197,406,606
Ensembl chr 2:197,392,698...197,407,519

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

affects methylation

ISO

Methapyrilene affects the methylation of KCNAB1 intron

NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:151,446,947...151,913,636

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

increases methylation

ISO

Methapyrilene results in increased methylation of KCNAB2 intron; Methapyrilene results in increased methylation of KCNAB2 promoter

NCBI chr 5:168,182,228...168,270,760
Ensembl chr 5:168,184,613...168,270,760

G

potassium voltage-gated channel subfamily C member 2

increases methylation

ISO

Methapyrilene results in increased methylation of KCNC2 intron

NCBI chr 7:49,586,274...49,770,212
Ensembl chr 7:49,586,136...49,770,212

G

potassium voltage-gated channel subfamily D member 3

increases methylation

ISO

Methapyrilene results in increased methylation of KCND3 intron

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel modifier subfamily G member 1

increases methylation

ISO

Methapyrilene results in increased methylation of KCNG1 intron

NCBI chr 3:177,379,593...177,412,986
Ensembl chr 3:177,392,031...177,411,507

G

potassium voltage-gated channel subfamily H member 2

increases methylation

ISO

Methapyrilene results in increased methylation of KCNH2 intron

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel subfamily H member 4

increases methylation

ISO

Methapyrilene results in increased methylation of KCNH4 intron

NCBI chr10:86,168,644...86,188,476
Ensembl chr10:86,168,644...86,188,476

G

potassium voltage-gated channel subfamily H member 8

increases methylation

ISO

Methapyrilene results in increased methylation of KCNH8 intron

NCBI chr 9:5,742,683...6,182,445
Ensembl chr 9:5,742,683...6,182,445

G

potassium voltage-gated channel interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of KCNIP1 intron

NCBI chr10:18,723,726...19,093,025
Ensembl chr10:18,723,726...19,093,087

G

potassium voltage-gated channel interacting protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of KCNIP3 intron

NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216

G

potassium voltage-gated channel interacting protein 4

increases methylation

ISO

Methapyrilene results in increased methylation of KCNIP4 intron

NCBI chr14:65,593,297...66,743,994
Ensembl chr14:65,593,366...66,743,993

G

potassium inwardly-rectifying channel, subfamily J, member 12

increases methylation

ISO

Methapyrilene results in increased methylation of KCNJ12 polyA tail

NCBI chr10:46,196,110...46,245,008
Ensembl chr10:46,195,428...46,260,169

G

potassium two pore domain channel subfamily K member 2

affects methylation

ISO

Methapyrilene affects the methylation of KCNK2 intron

NCBI chr13:103,297,387...103,494,686
Ensembl chr13:103,297,393...103,494,686

G

potassium two pore domain channel subfamily K member 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of KCNK4 intron

NCBI chr 1:213,547,577...213,558,706
Ensembl chr 1:213,547,577...213,555,861

G

potassium calcium-activated channel subfamily M alpha 1

affects methylation
increases expression
decreases expression

ISO

Methapyrilene affects the methylation of KCNMA1 intron
Methapyrilene results in increased expression of KCNMA1 mRNA
Methapyrilene results in decreased expression of KCNMA1 mRNA

PMID:30157460 PMID:31555880 PMID:35690182

NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117

G

potassium calcium-activated channel subfamily N member 3

affects methylation

ISO

Methapyrilene affects the methylation of KCNN3 intron

NCBI chr 2:177,227,276...177,378,849
Ensembl chr 2:177,234,327...177,379,693

G

potassium voltage-gated channel subfamily Q member 1

affects methylation

ISO

Methapyrilene affects the methylation of KCNQ1 intron

NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072

G

potassium voltage-gated channel subfamily Q member 3

increases methylation

ISO

Methapyrilene results in increased methylation of KCNQ3 intron

NCBI chr 7:99,614,089...99,914,736
Ensembl chr 7:99,619,544...99,914,610

G

potassium sodium-activated channel subfamily T member 1

increases methylation

ISO

Methapyrilene results in increased methylation of KCNT1 intron

NCBI chr 3:29,081,071...29,136,902
Ensembl chr 3:29,081,321...29,134,768

G

potassium channel tetramerization domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of KCTD1 intron

NCBI chr18:6,396,947...6,591,026
Ensembl chr18:6,396,947...6,515,191

G

potassium channel tetramerization domain containing 3

increases methylation

ISO

Methapyrilene results in increased methylation of KCTD3 intron

NCBI chr13:103,041,488...103,080,069
Ensembl chr13:103,041,490...103,080,009

G

potassium channel tetramerization domain containing 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of KCTD5 intron

NCBI chr10:13,583,781...13,609,762
Ensembl chr10:13,583,781...13,610,062

G

lysine demethylase 4A

affects methylation

ISO

Methapyrilene affects the methylation of KDM4A intron

NCBI chr 5:136,958,178...137,004,942
Ensembl chr 5:136,958,178...137,004,951

G

lysine demethylase 4B

increases methylation

ISO

Methapyrilene results in increased methylation of KDM4B intron

NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,245,899...1,324,384

G

lysine demethylase 5A

increases methylation

ISO

Methapyrilene results in increased methylation of KDM5A intron

NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121

G

lysine demethylase 6B

decreases expression

EXP

Methapyrilene results in decreased expression of KDM6B mRNA

NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,619,544...54,629,610

G

lysine demethylase 7A

increases methylation

ISO

Methapyrilene results in increased methylation of KDM7A intron

NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:68,871,677...68,931,506

G

KH domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of KHDC1 intron

NCBI chr 9:31,309,032...31,311,266
Ensembl chr 9:31,296,805...31,311,422

G

KH-type splicing regulatory protein

increases methylation

ISO

Methapyrilene results in increased methylation of KHSRP intron

NCBI chr 9:1,949,557...1,959,400
Ensembl chr 9:1,949,557...1,959,497

G

KIAA0319 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of KIAA0319 exon

NCBI chr17:40,587,001...40,654,525
Ensembl chr17:40,590,546...40,653,679

G

KIAA0825 homolog

decreases methylation

ISO

Methapyrilene results in decreased methylation of KIAA0825 intron

NCBI chr 2:8,606,257...9,167,308
Ensembl chr 2:8,606,281...9,167,180

G

KIAA0930 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of KIAA0930 intron

NCBI chr 7:117,947,898...117,987,601
Ensembl chr 7:117,947,898...117,987,636

G

KIAA1671 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of KIAA1671 intron

NCBI chr12:49,069,929...49,212,604
Ensembl chr12:49,069,940...49,212,604

G

KIAA2012 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of KIAA2012 intron

NCBI chr 9:68,453,459...68,599,150
Ensembl chr 9:68,461,495...68,570,706

G

kinesin family member 11

increases expression

EXP

Methapyrilene results in increased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 16B

decreases expression

EXP

Methapyrilene results in decreased expression of KIF16B mRNA

NCBI chr 3:150,428,233...150,707,755
Ensembl chr 3:150,366,838...150,707,770

G

kinesin family member 19

increases methylation

ISO

Methapyrilene results in increased methylation of KIF19 exon; Methapyrilene results in increased methylation of KIF19 intron

NCBI chr10:100,298,912...100,325,591
Ensembl chr10:100,299,275...100,325,767

G

kinesin family member 1A

increases methylation

ISO

Methapyrilene results in increased methylation of KIF1A intron

NCBI chr 9:101,010,447...101,094,891
Ensembl chr 9:101,010,447...101,094,777

G

kinesin family member 26A

affects methylation

ISO

Methapyrilene affects the methylation of KIF26A intron

NCBI chr 6:137,035,986...137,072,027
Ensembl chr 6:137,033,789...137,072,022

G

kinesin family member 26B

affects methylation

ISO

Methapyrilene affects the methylation of KIF26B intron

NCBI chr13:92,815,427...93,221,071
Ensembl chr13:92,815,427...93,215,453

G

kinesin family member 4A

decreases methylation

ISO

Methapyrilene results in decreased methylation of KIF4A intron

NCBI chr X:69,761,803...69,864,335
Ensembl chr X:69,761,883...69,864,335

G

kinesin family member 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of KIF6 intron

NCBI chr 9:18,573,925...18,870,789
Ensembl chr 9:18,573,789...18,870,729

G

kinesin family member C1

increases expression

EXP

Methapyrilene results in increased expression of KIFC1 mRNA

NCBI chr20:5,000,929...5,018,967
Ensembl chr20:5,000,648...5,018,988

G

kirre like nephrin family adhesion molecule 3

increases methylation

ISO

Methapyrilene results in increased methylation of KIRREL3 intron

NCBI chr 8:41,123,692...41,663,528
Ensembl chr 8:41,123,878...41,664,147

G

KLF transcription factor 13

increases methylation

ISO

Methapyrilene results in increased methylation of KLF13 intron

NCBI chr 1:126,917,671...126,948,436
Ensembl chr 1:126,916,781...126,961,056

G

KLF transcription factor 15

decreases expression

EXP

Methapyrilene results in decreased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

KLF transcription factor 16

increases methylation

ISO

Methapyrilene results in increased methylation of KLF16 intron

NCBI chr 7:9,789,185...9,799,004
Ensembl chr 7:9,775,042...9,798,999

G

kelch-like family member 2

decreases expression

EXP

Methapyrilene results in decreased expression of KLHL2 mRNA

NCBI chr16:29,627,171...29,739,782
Ensembl chr16:29,627,237...29,739,957

G

kelch-like family member 24

decreases expression

EXP

Methapyrilene results in decreased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

kelch-like family member 26

increases methylation

ISO

Methapyrilene results in increased methylation of KLHL26 intron

NCBI chr16:18,986,095...19,011,297
Ensembl chr16:18,985,865...19,011,297

G

kelch-like family member 29

increases methylation

ISO

Methapyrilene results in increased methylation of KLHL29 exon; Methapyrilene results in increased methylation of KLHL29 intron

NCBI chr 6:33,805,922...34,110,055
Ensembl chr 6:33,805,922...34,110,055

G

kelch-like family member 5

increases methylation

ISO

Methapyrilene results in increased methylation of KLHL5 polyA tail

NCBI chr14:43,497,915...43,565,833
Ensembl chr14:43,497,918...43,537,894

G

kelch-like family member 7

decreases expression

EXP

Methapyrilene results in decreased expression of KLHL7 mRNA

NCBI chr 4:11,898,766...11,947,796
Ensembl chr 4:11,898,769...11,947,796

G

kelch-like family member 9

decreases expression

EXP

Methapyrilene results in decreased expression of KLHL9 mRNA

NCBI chr 5:108,449,492...108,453,676
Ensembl chr 5:108,437,583...108,454,140

G

lysine methyltransferase 2A

increases methylation

ISO

Methapyrilene results in increased methylation of KMT2A exon

NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317

G

lysine methyltransferase 2B

increases methylation

ISO

Methapyrilene results in increased methylation of KMT2B exon

NCBI chr 1:94,949,144...94,969,239
Ensembl chr 1:94,949,144...94,968,441

G

kinase non-catalytic C-lobe domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of KNDC1 intron

NCBI chr 1:204,119,597...204,167,967
Ensembl chr 1:204,119,659...204,167,965

G

kinetochore-localized astrin/SPAG5 binding protein

increases expression

EXP

Methapyrilene results in increased expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418

G

karyopherin subunit alpha 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of KPNA5 intron

NCBI chr20:31,365,647...31,430,793
Ensembl chr20:31,365,656...31,430,792

G

lysine-rich coiled-coil 1

decreases expression

EXP

Methapyrilene results in decreased expression of KRCC1 mRNA

NCBI chr 4:104,819,958...104,832,987
Ensembl chr 4:104,819,190...104,855,484

G

KRIT1, ankyrin repeat containing

decreases expression

EXP

Methapyrilene results in decreased expression of KRIT1 mRNA

NCBI chr 4:31,253,918...31,288,066
Ensembl chr 4:31,253,918...31,288,073

G

keratin 18

increases expression
affects expression

EXP

Methapyrilene results in increased expression of KRT18 mRNA
Methapyrilene affects the expression of KRT18 protein

PMID:28935588 PMID:30467583

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

keratin 23

increases methylation

ISO

Methapyrilene results in increased methylation of KRT23 exon

NCBI chr10:84,930,603...84,946,929
Ensembl chr10:84,930,603...84,946,929

G

keratin 33A

decreases methylation

ISO

Methapyrilene results in decreased methylation of KRT33A exon

NCBI chr10:85,442,988...85,447,947
Ensembl chr10:85,442,988...85,447,947

G

keratin 5

increases methylation

ISO

Methapyrilene results in increased methylation of KRT5 exon

NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569

G

keratin 73

increases expression

EXP

Methapyrilene results in increased expression of KRT73 protein

NCBI chr 7:134,806,517...134,815,028
Ensembl chr 7:134,806,517...134,815,028

G

keratin 8

increases expression
affects expression

EXP

Methapyrilene results in increased expression of KRT8 mRNA
Methapyrilene affects the expression of KRT8 protein

PMID:28935588 PMID:30467583

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

kinase suppressor of ras 1

increases methylation
decreases methylation

ISO

Methapyrilene results in increased methylation of KSR1 5' UTR
Methapyrilene results in decreased methylation of KSR1 exon; Methapyrilene results in decreased methylation of KSR1 intron

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082

G

kinase suppressor of ras 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of KSR2 intron

NCBI chr12:44,462,579...44,848,555
Ensembl chr12:44,471,038...44,848,308

G

kinectin 1

decreases expression

EXP

Methapyrilene results in decreased expression of KTN1 mRNA

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

kynureninase

decreases expression

EXP

Methapyrilene results in decreased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

L-2-hydroxyglutarate dehydrogenase

increases methylation

ISO

Methapyrilene results in increased methylation of L2HGDH intron

NCBI chr 6:93,900,427...93,941,534
Ensembl chr 6:93,900,427...93,941,534

G

L3MBTL histone methyl-lysine binding protein 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of L3MBTL2 intron

NCBI chr 7:115,066,427...115,087,625
Ensembl chr 7:115,066,486...115,087,598

G

L3MBTL histone methyl-lysine binding protein 4

increases methylation

ISO

Methapyrilene results in increased methylation of L3MBTL4 intron

NCBI chr 9:115,741,720...116,194,592
Ensembl chr 9:115,776,638...116,194,591

G

laminin subunit alpha 3

increases methylation
affects methylation

ISO

Methapyrilene results in increased methylation of LAMA3 intron
Methapyrilene affects the methylation of LAMA3 exon

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

laminin subunit gamma 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of LAMC3 exon

NCBI chr 3:35,562,989...35,624,460
Ensembl chr 3:35,562,713...35,624,460

G

LARGE xylosyl- and glucuronyltransferase 1

affects methylation

ISO

Methapyrilene affects the methylation of LARGE intron

NCBI chr19:11,609,004...12,057,174
Ensembl chr19:11,609,004...12,054,707

G

La ribonucleoprotein 1, translational regulator

decreases expression

EXP

Methapyrilene results in decreased expression of LARP1 mRNA

NCBI chr10:42,691,833...42,746,816
Ensembl chr10:42,691,600...42,746,816

G

La ribonucleoprotein 4B

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of LARP4B mRNA
Methapyrilene results in increased methylation of LARP4B intron

PMID:30157460 PMID:30467583

NCBI chr17:65,813,125...65,908,920
Ensembl chr17:65,830,022...65,908,676

G

leucyl-tRNA synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of LARS1 mRNA

NCBI chr18:34,452,567...34,507,030
Ensembl chr18:34,452,561...34,506,938

G

LBH domain containing 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of LBHD2 polyA tail

NCBI chr 6:136,263,383...136,268,422
Ensembl chr 6:136,263,572...136,268,422

G

ligand dependent nuclear receptor corepressor

decreases methylation

ISO

Methapyrilene results in decreased methylation of LCOR intron

NCBI chr 1:250,247,965...250,354,985
Ensembl chr 1:250,247,934...250,354,985

G

ligand dependent nuclear receptor corepressor-like

increases methylation

ISO

Methapyrilene results in increased methylation of LCORL intron

NCBI chr14:69,482,919...69,620,269
Ensembl chr14:69,518,837...69,587,177

G

LIM domain binding 3

increases methylation

ISO

Methapyrilene results in increased methylation of LDB3 intron

NCBI chr16:9,862,161...9,926,338
Ensembl chr16:9,862,161...9,926,985

G

low density lipoprotein receptor class A domain containing 4

increases methylation

ISO

Methapyrilene results in increased methylation of LDLRAD4 intron

NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064

G

lymphoid enhancer binding factor 1

increases methylation

ISO

Methapyrilene results in increased methylation of LEF1 intron

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

leukocyte receptor cluster member 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of LENG8 intron

NCBI chr 1:79,113,038...79,124,868
Ensembl chr 1:79,113,038...79,124,738

G

leptin

decreases expression

EXP

Methapyrilene results in decreased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

leucine zipper and EF-hand containing transmembrane protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of LETM1 intron

NCBI chr14:81,167,268...81,206,776
Ensembl chr14:81,162,309...81,209,459

G

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

decreases methylation

ISO

Methapyrilene results in decreased methylation of LFNG intron

NCBI chr12:19,144,474...19,152,951
Ensembl chr12:19,124,662...19,152,918

G

galectin 3

increases expression

EXP

Methapyrilene results in increased expression of LGALS3 mRNA

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737

G

galectin 9

decreases expression

EXP

Methapyrilene results in decreased expression of LGALS9 mRNA

NCBI chr10:64,405,044...64,428,249
Ensembl chr10:64,405,044...64,428,070

G

galectin-like

decreases expression

EXP

Methapyrilene results in decreased expression of LGALSL mRNA

NCBI chr14:99,198,340...99,205,846
Ensembl chr14:99,198,339...99,206,487

G

leucine-rich repeat LGI family, member 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of LGI2 intron

NCBI chr14:62,628,746...62,656,231
Ensembl chr14:62,596,150...62,656,188

G

leucine-rich repeat-containing G protein-coupled receptor 6

increases methylation

ISO

Methapyrilene results in increased methylation of LGR6 intron

NCBI chr13:48,976,193...49,095,870
Ensembl chr13:48,976,193...49,095,857

G

LHFPL tetraspan subfamily member 3

increases methylation

ISO

Methapyrilene results in increased methylation of LHFPL3 intron

G

LHFPL tetraspan subfamily member 6

increases methylation

ISO

Methapyrilene results in increased methylation of LHFPL6 intron

NCBI chr 2:139,276,810...139,474,740
Ensembl chr 2:139,276,789...139,474,737

G

LHFPL tetraspan subfamily member 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of LHFPL7 intron

NCBI chr12:49,053,607...49,057,890
Ensembl chr12:49,053,740...49,057,890

G

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

increases methylation

ISO

Methapyrilene results in increased methylation of LHPP intron

NCBI chr 1:196,833,516...196,924,687
Ensembl chr 1:196,833,523...196,924,871

G

LIM homeobox 4

increases methylation

ISO

Methapyrilene results in increased methylation of LHX4 intron

NCBI chr13:70,423,768...70,477,337
Ensembl chr13:70,427,399...70,467,505

G

LIM homeobox 6

increases methylation

ISO

Methapyrilene results in increased methylation of LHX6 intron

NCBI chr 3:39,829,846...39,853,681
Ensembl chr 3:39,830,990...39,853,559

G

leukocyte immunoglobulin like receptor A5

increases methylation

ISO

Methapyrilene results in increased methylation of LILRA5 polyA tail

NCBI chr 1:79,011,865...79,073,860
Ensembl chr 1:79,045,546...79,050,111

G

LIM domain and actin binding 1

increases methylation

ISO

Methapyrilene results in increased methylation of LIMA1 intron

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

LIM zinc finger domain containing 2

decreases expression
increases methylation

EXP
ISO

Methapyrilene results in decreased expression of LIMS2 mRNA
Methapyrilene results in increased methylation of LIMS2 intron

PMID:30157460 PMID:30467583

NCBI chr18:23,828,164...23,866,363
Ensembl chr18:23,837,686...23,867,086

G

lin-28 homolog B

increases methylation

ISO

Methapyrilene results in increased methylation of LIN28B intron

NCBI chr20:50,447,700...50,547,135
Ensembl chr20:50,450,971...50,541,968

G

lin-52 DREAM MuvB core complex component

increases methylation

ISO

Methapyrilene results in increased methylation of LIN52 intron

NCBI chr 6:109,829,896...109,927,122
Ensembl chr 6:109,830,131...109,925,310

G

lin-7 homolog B, crumbs cell polarity complex component

increases expression

EXP

Methapyrilene results in increased expression of LIN7B protein

NCBI chr 1:104,983,368...104,986,795
Ensembl chr 1:104,982,771...104,986,078

G

leucine rich repeat and Ig domain containing 1

increases methylation

ISO

Methapyrilene results in increased methylation of LINGO1 intron; Methapyrilene results in increased methylation of LINGO1 promoter

NCBI chr 8:65,907,275...66,089,485
Ensembl chr 8:65,897,844...66,091,740

G

leucine rich repeat and Ig domain containing 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of LINGO2 intron

NCBI chr 5:55,166,250...56,488,672
Ensembl chr 5:55,156,997...56,489,155

G

lipase C, hepatic type

increases expression

EXP

Methapyrilene results in increased expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lipase G, endothelial type

increases methylation

ISO

Methapyrilene results in increased methylation of LIPG 3' UTR

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

lectin, mannose-binding 2-like

increases methylation

ISO

Methapyrilene results in increased methylation of LMAN2L intron

NCBI chr 9:46,157,596...46,181,151
Ensembl chr 9:46,157,596...46,181,207

G

lipase maturation factor 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of LMF1 intron

NCBI chr10:15,094,432...15,188,665
Ensembl chr10:15,098,138...15,188,664

G

leishmanolysin like peptidase

increases methylation

ISO

Methapyrilene results in increased methylation of LMLN intron

NCBI chr11:81,161,330...81,230,972
Ensembl chr11:81,161,330...81,229,447

G

lamin A/C

decreases methylation

ISO

Methapyrilene results in decreased methylation of LMNA intron

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

LIM domain only 4

decreases expression

EXP

Methapyrilene results in decreased expression of LMO4 mRNA

NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:235,924,403...235,941,275

G

leiomodin 1

increases methylation

ISO

Methapyrilene results in increased methylation of LMOD1 intron

NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116

G

LIM homeobox transcription factor 1 beta

affects methylation

ISO

Methapyrilene affects the methylation of LMX1B intron

NCBI chr 3:37,257,025...37,338,675
Ensembl chr 3:37,259,855...37,338,557

G

mucin-12-like

increases methylation

ISO

Methapyrilene results in increased methylation of MUC12 promoter

NCBI chr12:25,127,100...25,137,925

G

lon peptidase 1, mitochondrial

decreases methylation

ISO

Methapyrilene results in decreased methylation of LONP1 intron

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427

G

lon peptidase 2, peroxisomal

increases methylation
decreases expression

ISO
EXP

Methapyrilene results in increased methylation of LONP2 polyA tail
Methapyrilene results in decreased expression of LONP2 mRNA

PMID:30157460 PMID:30467583

NCBI chr19:36,580,736...36,672,242
Ensembl chr19:36,580,736...36,672,242

G

LON peptidase N-terminal domain and ring finger 2

increases methylation

ISO

Methapyrilene results in increased methylation of LONRF2 intron

NCBI chr 9:48,524,962...48,566,353
Ensembl chr 9:48,530,549...48,570,807

G

lysyl oxidase

decreases expression

EXP

Methapyrilene results in decreased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lysyl oxidase-like 2

increases methylation

ISO

Methapyrilene results in increased methylation of LOXL2 intron

NCBI chr15:51,091,547...51,182,843
Ensembl chr15:51,069,997...51,182,842

G

lysophosphatidic acid receptor 5

increases methylation

ISO

Methapyrilene results in increased methylation of LPAR5 polyA tail

NCBI chr 4:159,556,735...159,570,216
Ensembl chr 4:159,554,805...159,571,894

G

lysophosphatidylcholine acyltransferase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of LPCAT1 intron

NCBI chr 1:31,594,621...31,644,946
Ensembl chr 1:31,594,622...31,644,946

G

lipin 2

decreases expression

EXP

Methapyrilene results in decreased expression of LPIN2 mRNA

NCBI chr 9:118,529,988...118,604,796
Ensembl chr 9:118,529,943...118,604,796

G

lipoprotein lipase

increases expression

EXP

Methapyrilene results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LPS responsive beige-like anchor protein

increases methylation

ISO

Methapyrilene results in increased methylation of LRBA intron

NCBI chr 2:173,919,330...174,500,536
Ensembl chr 2:173,921,747...174,500,527

G

leucine-rich repeats and guanylate kinase domain containing

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRGUK intron

NCBI chr 4:63,614,431...63,737,463
Ensembl chr 4:63,614,461...63,763,564

G

leucine-rich repeats and immunoglobulin-like domains 1

increases methylation

ISO

Methapyrilene results in increased methylation of LRIG1 intron

NCBI chr 4:128,687,723...128,788,219
Ensembl chr 4:128,687,723...128,788,219

G

leucine rich melanocyte differentiation associated

increases methylation

ISO

Methapyrilene results in increased methylation of LRMDA intron

NCBI chr15:1,275,139...2,334,153
Ensembl chr15:1,274,199...2,334,089

G

LDL receptor related protein 3

decreases expression

EXP

Methapyrilene results in decreased expression of LRP3 mRNA

NCBI chr 1:96,980,762...96,996,157
Ensembl chr 1:96,981,815...96,996,057

G

LDL receptor related protein 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRP5 intron

NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822

G

LDL receptor related protein 6

decreases expression

EXP

Methapyrilene results in decreased expression of LRP6 mRNA

NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716

G

LDL receptor related protein 8

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRP8 intron

NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:127,792,299...127,864,207

G

leucine-rich pentatricopeptide repeat containing

decreases expression

EXP

Methapyrilene results in decreased expression of LRPPRC mRNA

NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116

G

leucine rich repeat containing 25

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRRC25 exon

NCBI chr16:18,840,867...18,847,722
Ensembl chr16:18,840,867...18,846,464

G

leucine rich repeat containing 3

increases methylation

ISO

Methapyrilene results in increased methylation of LRRC3 3' UTR

NCBI chr20:10,758,399...10,763,358
Ensembl chr20:10,758,357...10,762,022

G

leucine rich repeat containing 32

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRRC32 intron

NCBI chr 1:162,196,995...162,209,563
Ensembl chr 1:162,197,653...162,209,563

G

leucine rich repeat containing 42

increases methylation

ISO

Methapyrilene results in increased methylation of LRRC42 intron

NCBI chr 5:127,243,484...127,264,599
Ensembl chr 5:127,243,486...127,264,599

G

leucine rich repeat containing 4B

increases methylation

ISO

Methapyrilene results in increased methylation of LRRC4B intron

NCBI chr 1:104,058,558...104,092,831
Ensembl chr 1:104,072,128...104,093,298

G

leucine rich repeat containing 7

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRRC7 intron

NCBI chr 2:249,792,441...250,294,267
Ensembl chr 2:249,805,448...250,293,718

G

leucine rich repeat containing 74A

increases methylation

ISO

Methapyrilene results in increased methylation of C14ORF166B intron

NCBI chr 6:112,117,226...112,147,152
Ensembl chr 6:112,117,241...112,148,068

G

leucine rich repeat containing 8 VRAC subunit C

increases methylation

ISO

Methapyrilene results in increased methylation of LRRC8C intron

NCBI chr14:4,528,721...4,621,259
Ensembl chr14:4,531,823...4,620,049

G

leucine rich repeat containing 8 VRAC subunit D

increases methylation

ISO

Methapyrilene results in increased methylation of LRRC8D intron

NCBI chr14:4,335,114...4,411,549
Ensembl chr14:4,332,130...4,445,639

G

leucine rich repeat and coiled-coil centrosomal protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRRCC1 intron

NCBI chr 2:88,746,904...88,781,532
Ensembl chr 2:88,746,443...88,781,542

G

LRR binding FLII interacting protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of LRRFIP1 intron

NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779

G

leucine-rich repeat kinase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRRK1 intron

NCBI chr 1:129,254,815...129,390,217
Ensembl chr 1:129,254,515...129,389,941

G

leucine-rich repeat kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of LRRK2 intron

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

leucine rich repeat neuronal 3

increases methylation

ISO

Methapyrilene results in increased methylation of LRRN3 intron

NCBI chr 6:64,216,164...64,247,293
Ensembl chr 6:64,215,878...64,247,614

G

leucine rich repeat transmembrane neuronal 3

increases methylation

ISO

Methapyrilene results in increased methylation of LRRTM3 intron

NCBI chr20:24,514,304...24,688,322
Ensembl chr20:24,514,284...24,689,002

G

leucine-rich repeats and transmembrane domains 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of LRTM2 5' UTR

NCBI chr 4:154,158,165...154,180,389
Ensembl chr 4:154,158,168...154,167,641

G

limbic system-associated membrane protein

increases methylation

ISO

Methapyrilene results in increased methylation of LSAMP intron

NCBI chr11:72,053,285...74,223,019
Ensembl chr11:72,053,285...72,702,134

G

LSM10, U7 small nuclear RNA associated

decreases expression

EXP

Methapyrilene results in decreased expression of LSM10 mRNA

NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:143,615,360...143,663,986

G

LSM12 homolog

increases methylation

ISO

Methapyrilene results in increased methylation of LSM12 intron

NCBI chr10:87,618,518...87,640,556
Ensembl chr10:87,618,518...87,640,556

G

LSM14A mRNA processing body assembly factor

decreases methylation

ISO

Methapyrilene results in decreased methylation of LSM14A intron

NCBI chr 1:96,101,990...96,146,578
Ensembl chr 1:96,101,992...96,146,448

G

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

EXP

Methapyrilene results in increased expression of LSM3 mRNA

NCBI chr 4:125,578,185...125,584,429
Ensembl chr 4:125,578,185...125,584,429

G

leucine-rich single-pass membrane protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of LSMEM1 intron

NCBI chr 6:62,978,880...62,988,750
Ensembl chr 6:62,978,885...62,988,750

G

lymphocyte-specific protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of LSP1 promoter

NCBI chr 1:207,044,157...207,077,891
Ensembl chr 1:207,044,159...207,077,893

G

lanosterol synthase

decreases methylation

ISO

Methapyrilene results in decreased methylation of LSS intron

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

latent transforming growth factor beta binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of LTBP2 intron

NCBI chr 6:110,161,029...110,261,586
Ensembl chr 6:110,161,029...110,257,298

G

listerin E3 ubiquitin protein ligase 1

decreases expression

EXP

Methapyrilene results in decreased expression of LTN1 mRNA

NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303

G

LTO1 maturation factor of ABCE1

increases expression

EXP

Methapyrilene results in increased expression of LTO1 mRNA

NCBI chr 1:209,502,900...209,510,237
Ensembl chr 1:209,498,312...209,517,347

G

lymphocyte antigen 6 family member G6E

increases methylation

ISO

Methapyrilene results in increased methylation of LY6G6E intron

NCBI chr20:3,749,352...3,752,578
Ensembl chr20:3,749,656...3,751,392

G

lymphocyte antigen 86

decreases methylation

ISO

Methapyrilene results in decreased methylation of LY86 intron

NCBI chr17:27,621,313...27,705,336
Ensembl chr17:27,621,313...27,692,743

G

lymphocyte antigen 96

decreases methylation

ISO

Methapyrilene results in decreased methylation of LY96 intron

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816

G

Ly6/Plaur domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of LYPD2 intron

NCBI chr 7:108,506,545...108,508,582
Ensembl chr 7:108,506,545...108,508,582

G

Ly6/Plaur domain containing 5

increases methylation

ISO

Methapyrilene results in increased methylation of LYPD5 intron

NCBI chr 1:89,057,719...89,069,696
Ensembl chr 1:89,057,891...89,069,696

G

Ly6/Plaur domain containing 6

decreases methylation

ISO

Methapyrilene results in decreased methylation of LYPD6 intron

NCBI chr 3:54,896,618...55,041,928
Ensembl chr 3:54,896,575...55,041,929

G

LYR motif containing 2

decreases expression

EXP

Methapyrilene results in decreased expression of LYRM2 mRNA

NCBI chr 5:51,994,540...51,996,818
Ensembl chr 5:51,994,543...51,997,979

G

lysozyme 2

increases expression

EXP

Methapyrilene results in increased expression of LYZ2 mRNA

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

mono-ADP ribosylhydrolase 1

affects methylation

ISO

Methapyrilene affects the methylation of MACROD1 intron

NCBI chr 1:213,675,413...213,831,571
Ensembl chr 1:213,675,406...213,816,348

G

mitotic arrest deficient 1 like 1

affects methylation

ISO

Methapyrilene affects the methylation of MAD1L1 intron

NCBI chr12:19,434,782...19,744,574
Ensembl chr12:19,434,746...19,744,567

G

mitotic arrest deficient 2 like 1

increases expression

EXP

Methapyrilene results in increased expression of MAD2L1 mRNA

NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:97,236,503...97,243,222

G

MAGE family member D1

increases methylation

ISO

Methapyrilene results in increased methylation of MAGED1 intron

NCBI chr X:63,416,464...63,423,167
Ensembl chr X:63,416,466...63,423,112

G

MAGE family member H1

decreases expression

EXP

Methapyrilene results in decreased expression of MAGEH1 mRNA

NCBI chr X:21,725,709...21,726,965
Ensembl chr X:21,718,669...21,727,219

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of MAGI1 mRNA

NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

increases methylation

ISO

Methapyrilene results in increased methylation of MAGI2 intron

NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199

G

membrane associated guanylate kinase, WW and PDZ domain containing 3

decreases expression

EXP

Methapyrilene results in decreased expression of MAGI3 mRNA

NCBI chr 2:194,206,587...194,405,468
Ensembl chr 2:194,206,934...194,405,157

G

mal, T-cell differentiation protein 2

decreases expression

EXP

Methapyrilene results in decreased expression of MAL2 mRNA

NCBI chr 7:87,790,239...87,823,219
Ensembl chr 7:87,790,239...87,850,403

G

MAM and LDL receptor class A domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MALRD1 intron

NCBI chr17:83,327,372...84,039,558
Ensembl chr17:83,327,372...84,039,559

G

MAM domain containing 4

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAMDC4 intron

NCBI chr 3:28,780,523...28,789,139
Ensembl chr 3:28,780,523...28,789,139

G

mastermind-like transcriptional coactivator 3

affects methylation

ISO

Methapyrilene affects the methylation of MAML3 intron

NCBI chr 2:137,871,267...138,288,615
Ensembl chr 2:137,871,267...138,287,960

G

mannosidase, alpha, class 1A, member 1

decreases expression

EXP

Methapyrilene results in decreased expression of MAN1A1 mRNA

NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584

G

mannosidase, alpha, class 1A, member 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAN1A2 intron

NCBI chr 2:190,636,134...190,784,975
Ensembl chr 2:190,615,094...190,784,975

G

mannosidase, alpha, class 1C, member 1

increases methylation

ISO

Methapyrilene results in increased methylation of MAN1C1 intron

NCBI chr 5:152,057,839...152,197,737
Ensembl chr 5:152,057,967...152,197,138

G

mannosidase, alpha, class 2A, member 1

decreases expression

EXP

Methapyrilene results in decreased expression of MAN2A1 mRNA

NCBI chr 9:111,698,913...111,855,257
Ensembl chr 9:111,698,913...111,867,850

G

mannosidase, alpha, class 2A, member 2

increases methylation

ISO

Methapyrilene results in increased methylation of MAN2A2 exon

NCBI chr 1:143,712,157...143,736,624
Ensembl chr 1:143,716,072...143,736,562

G

mannosidase beta

increases methylation

ISO

Methapyrilene results in increased methylation of MANBA intron

NCBI chr 2:226,583,968...226,676,520
Ensembl chr 2:226,583,917...226,676,517

G

mannosidase, endo-alpha

decreases expression

EXP

Methapyrilene results in decreased expression of MANEA mRNA

NCBI chr 5:44,992,937...45,015,084
Ensembl chr 5:44,992,937...45,015,084

G

monoamine oxidase A

decreases expression

EXP

Methapyrilene results in decreased expression of MAOA mRNA

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases expression

EXP

Methapyrilene results in decreased expression of MAOB mRNA

PMID:16393664 PMID:30467583

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 3

increases expression

EXP

Methapyrilene results in increased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase kinase kinase 14

increases methylation

ISO

Methapyrilene results in increased methylation of MAP3K14 intron

NCBI chr10:88,665,417...88,715,669
Ensembl chr10:88,665,417...88,715,592

G

mitogen-activated protein kinase kinase kinase 15

increases methylation

ISO

Methapyrilene results in increased methylation of MAP3K15 intron

NCBI chr X:38,522,143...38,667,746
Ensembl chr X:38,521,183...38,667,676

G

mitogen-activated protein kinase kinase kinase 20

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAP3K20 intron

NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538

G

mitogen-activated protein kinase kinase kinase 6

increases expression

EXP

Methapyrilene results in increased expression of MAP3K6 mRNA

NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111

G

MAP3K7 C-terminal like

increases methylation

ISO

Methapyrilene results in increased methylation of MAP3K7CL intron

NCBI chr11:40,276,839...40,321,848
Ensembl chr11:40,277,688...40,321,847

G

mitogen activated protein kinase kinase kinase kinase 2

increases methylation

ISO

Methapyrilene results in increased methylation of MAP4K2 exon

NCBI chr 1:213,074,360...213,090,042
Ensembl chr 1:213,074,377...213,096,987

G

mitogen-activated protein kinase kinase kinase kinase 3

affects methylation
decreases expression

ISO
EXP

Methapyrilene affects the methylation of MAP4K3 intron
Methapyrilene results in decreased expression of MAP4K3 mRNA

PMID:30157460 PMID:30467583

NCBI chr 6:20,029,246...20,198,583
Ensembl chr 6:20,029,397...20,198,583

G

microtubule-associated protein 6

increases expression

EXP

Methapyrilene results in increased expression of MAP6 mRNA

NCBI chr 1:162,980,339...163,046,548
Ensembl chr 1:162,980,181...163,046,548

G

MAP6 domain containing 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAP6D1 intron

NCBI chr11:94,238,552...94,244,781
Ensembl chr11:94,238,542...94,246,901

G

microtubule-associated protein 7

decreases expression

EXP

Methapyrilene results in decreased expression of MAP7 mRNA

NCBI chr 1:16,730,000...16,857,173
Ensembl chr 1:16,730,075...16,857,170

G

mitogen activated protein kinase 14

decreases expression

EXP

Methapyrilene results in decreased expression of MAPK14 mRNA

PMID:16393664 PMID:30467583

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen-activated protein kinase 1 interacting protein 1-like

decreases expression

EXP

Methapyrilene results in decreased expression of MAPK1IP1L mRNA

NCBI chr15:23,024,757...23,051,189

G

mitogen activated protein kinase 3

increases expression
increases methylation

EXP
ISO

Methapyrilene results in increased expression of MAPK3 protein
Methapyrilene results in increased methylation of MAPK3 intron

PMID:30157460 PMID:30467583

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 6

increases expression

EXP

Methapyrilene results in increased expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

MAPK associated protein 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAPKAP1 intron

NCBI chr 3:38,113,268...38,315,913
Ensembl chr 3:38,113,323...38,315,913

G

MAPK activated protein kinase 5

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAPKAPK5 intron

NCBI chr12:40,654,220...40,673,740
Ensembl chr12:40,654,423...40,677,170

G

mitogen activated protein kinase binding protein 1

increases methylation

ISO

Methapyrilene results in increased methylation of MAPKBP1 intron

NCBI chr 3:127,401,612...127,452,152
Ensembl chr 3:127,401,612...127,449,983

G

membrane associated ring-CH-type finger 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MARCHF1 intron

NCBI chr16:28,022,159...28,880,872
Ensembl chr16:28,022,159...28,881,054

G

membrane associated ring-CH-type finger 10

increases methylation

ISO

Methapyrilene results in increased methylation of MARCHF10 exon

NCBI chr10:90,832,647...90,975,700
Ensembl chr10:90,832,648...90,922,722

G

membrane associated ring-CH-type finger 6

decreases expression

EXP

Methapyrilene results in decreased expression of MARCHF6 mRNA

NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792

G

macrophage receptor with collagenous structure

increases methylation

ISO

Methapyrilene results in increased methylation of MARCO exon

NCBI chr13:34,169,011...34,210,340
Ensembl chr13:34,169,011...34,201,255

G

microtubule affinity regulating kinase 3

decreases expression

EXP

Methapyrilene results in decreased expression of MARK3 mRNA

NCBI chr 6:136,447,327...136,537,409
Ensembl chr 6:136,448,531...136,537,404

G

methionyl-tRNA synthetase 1

decreases expression

EXP

Methapyrilene results in decreased expression of MARS1 mRNA

NCBI chr 7:65,006,456...65,023,880
Ensembl chr 7:64,998,544...65,023,753

G

MBL associated serine protease 2

increases methylation

ISO

Methapyrilene results in increased methylation of MASP2 intron

NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:164,308,991...164,332,705

G

microtubule associated serine/threonine kinase family member 4

increases methylation

ISO

Methapyrilene results in increased methylation of MAST4 intron

NCBI chr 2:35,627,190...36,219,090
Ensembl chr 2:35,627,190...36,218,832

G

methionine adenosyltransferase 1A

decreases expression

EXP

Methapyrilene results in decreased expression of MAT1A mRNA; Methapyrilene results in decreased expression of MAT1A protein

NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367

G

microtubule associated tyrosine carboxypeptidase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MATCAP1 intron

NCBI chr19:50,067,978...50,076,715
Ensembl chr19:50,069,015...50,076,709

G

matrilin 2

increases methylation

ISO

Methapyrilene results in increased methylation of MATN2 intron

NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:67,380,168...67,530,153

G

matrilin 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of MATN3 intron

NCBI chr 6:37,467,729...37,487,776
Ensembl chr 6:37,467,729...37,487,776

G

MYC associated zinc finger protein

decreases methylation

ISO

Methapyrilene results in decreased methylation of MAZ exon

NCBI chr 1:191,060,271...191,065,722
Ensembl chr 1:191,060,280...191,065,339

G

myoglobin

increases methylation

ISO

Methapyrilene results in increased methylation of MB intron

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958

G

methyl-CpG binding domain protein 3

increases methylation

ISO

Methapyrilene results in increased methylation of MBD3 polyA tail

NCBI chr 7:9,961,053...9,970,845
Ensembl chr 7:9,963,797...9,970,265

G

mannose binding lectin 2

decreases expression

EXP

Methapyrilene results in decreased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546

G

metallo-beta-lactamase domain containing 1

decreases expression

EXP

Methapyrilene results in decreased expression of MBLAC1 mRNA

NCBI chr12:22,185,142...22,186,404
Ensembl chr12:22,184,917...22,200,899

G

muscleblind-like splicing regulator 1

increases methylation

ISO

Methapyrilene results in increased methylation of MBNL1 exon

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

muscleblind-like splicing regulator 2

decreases expression

EXP

Methapyrilene results in decreased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

myelin basic protein

increases methylation

ISO

Methapyrilene results in increased methylation of MBP intron

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

MCC regulator of WNT signaling pathway

increases methylation

ISO

Methapyrilene results in increased methylation of MCC intron

NCBI chr18:37,042,350...37,517,114
Ensembl chr18:37,049,253...37,517,076

G

methylcrotonyl-CoA carboxylase subunit 1

decreases expression

EXP

Methapyrilene results in decreased expression of MCCC1 mRNA

NCBI chr 2:120,727,313...120,779,334
Ensembl chr 2:120,727,316...120,779,554

G

methylcrotonyl-CoA carboxylase subunit 2

decreases expression

EXP

Methapyrilene results in decreased expression of MCCC2 mRNA

NCBI chr 2:33,039,044...33,110,092
Ensembl chr 2:33,039,045...33,110,299

G

MCF.2 cell line derived transforming sequence-like

increases methylation

ISO

Methapyrilene results in increased methylation of MCF2L intron

NCBI chr16:83,209,277...83,355,683
Ensembl chr16:83,209,280...83,354,956

G

minichromosome maintenance complex component 6

increases expression

EXP

Methapyrilene results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

mucolipin TRP cation channel 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of MCOLN2 intron

NCBI chr 2:237,714,100...237,762,979
Ensembl chr 2:237,714,084...237,762,978

G

mitochondrial calcium uniporter

increases methylation

ISO

Methapyrilene results in increased methylation of MCU intron

NCBI chr20:27,960,520...28,123,103
Ensembl chr20:27,961,327...28,123,103

G

MyoD family inhibitor

increases methylation

ISO

Methapyrilene results in increased methylation of MDFI intron

NCBI chr 9:20,654,359...20,672,768
Ensembl chr 9:20,654,417...20,672,767

G

MyoD family inhibitor domain containing

decreases expression

EXP

Methapyrilene results in decreased expression of MDFIC mRNA

NCBI chr 4:44,938,301...45,018,157
Ensembl chr 4:44,938,480...45,018,156

G

MDM2 proto-oncogene

decreases expression
increases expression
increases phosphorylation

EXP

Methapyrilene results in decreased expression of MDM2 mRNA
Methapyrilene results in increased expression of MDM2 mRNA
Methapyrilene results in increased phosphorylation of MDM2 protein

PMID:15890375 PMID:18619722 PMID:22584684 PMID:25242409 PMID:26558467 More...

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

midasin AAA ATPase 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MDN1 exon; Methapyrilene results in decreased methylation of MDN1 intron

NCBI chr 5:51,851,785...51,982,688
Ensembl chr 5:51,851,809...51,982,688

G

malic enzyme 3

increases methylation

ISO

Methapyrilene results in increased methylation of ME3 intron

NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026

G

MDS1 and EVI1 complex locus

increases methylation

ISO

Methapyrilene results in increased methylation of MECOM intron

NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:114,837,840...115,393,038

G

methyl CpG binding protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of MECP2 intron

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:156,941,234...156,943,560

G

mediator complex subunit 13

decreases methylation

ISO

Methapyrilene results in decreased methylation of MED13 intron

NCBI chr10:71,584,354...71,674,614
Ensembl chr10:71,584,354...71,673,901

G

mediator complex subunit 13L

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of MED13L mRNA
Methapyrilene results in decreased methylation of MED13L intron

PMID:30157460 PMID:30467583

NCBI chr12:43,468,556...43,665,819
Ensembl chr12:43,468,556...43,665,819

G

mediator complex subunit 21

increases expression

EXP

Methapyrilene results in increased expression of MED21 mRNA

NCBI chr 4:181,291,191...181,314,504
Ensembl chr 4:181,291,271...181,298,234

G

mediator complex subunit 27

increases methylation

ISO

Methapyrilene results in increased methylation of MED27 intron

NCBI chr 3:33,027,240...33,201,240
Ensembl chr 3:33,027,525...33,201,240

G

mediator complex subunit 4

increases expression

EXP

Methapyrilene results in increased expression of MED4 mRNA

NCBI chr15:55,106,079...55,116,354
Ensembl chr15:55,105,998...55,116,429

G

maternally expressed 3

increases methylation

ISO

Methapyrilene results in increased methylation of MEG3 intron

NCBI chr 6:134,274,056...134,306,249

G

multiple EGF-like-domains 11

increases methylation

ISO

Methapyrilene results in increased methylation of MEGF11 intron

NCBI chr 8:73,787,568...74,113,228
Ensembl chr 8:73,787,397...74,111,690

G

multiple EGF-like-domains 6

increases methylation

ISO

Methapyrilene results in increased methylation of MEGF6 intron

NCBI chr 5:170,020,699...170,121,557
Ensembl chr 5:170,020,778...170,121,554

G

multiple EGF-like-domains 8

increases methylation

ISO

Methapyrilene results in increased methylation of MEGF8 exon

NCBI chr 1:90,030,057...90,079,423
Ensembl chr 1:90,030,388...90,079,422

G

meiosis initiator

increases methylation

ISO

Methapyrilene results in increased methylation of MEIOSIN intron

NCBI chr 1:87,873,020...87,896,092
Ensembl chr 1:87,872,760...87,906,314

G

Meis homeobox 3

decreases methylation

ISO

Methapyrilene results in decreased methylation of MEIS3 intron

NCBI chr 1:85,986,602...86,000,873
Ensembl chr 1:85,990,050...86,000,873

G

maternal embryonic leucine zipper kinase

decreases expression

EXP

Methapyrilene results in decreased expression of MELK mRNA

NCBI chr 5:63,336,151...63,396,254
Ensembl chr 5:63,336,106...63,396,247

G

mesenchyme homeobox 1

increases methylation

ISO

Methapyrilene results in increased methylation of MEOX1 intron

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:87,318,695...87,337,976

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

decreases expression

EXP

Methapyrilene results in decreased expression of METTL14 mRNA

NCBI chr 2:214,215,165...214,231,412
Ensembl chr 2:214,215,165...214,231,412

G

methyltransferase 16, RNA N6-adenosine

increases methylation

ISO

Methapyrilene results in increased methylation of METTL16 3' UTR

NCBI chr10:60,139,317...60,185,438
Ensembl chr10:60,139,330...60,187,571

G

methyltransferase 21C, AARS1 lysine

increases methylation

ISO

Methapyrilene results in increased methylation of METTL21C exon

NCBI chr 9:53,625,473...53,637,220
Ensembl chr 9:53,626,093...53,637,204

G

methyltransferase 23, arginine

decreases expression

EXP

Methapyrilene results in decreased expression of METTL23 mRNA

NCBI chr10:102,546,102...102,550,782
Ensembl chr10:102,545,430...102,553,909

G

methyltransferase 8, tRNA N3-cytidine

increases methylation

ISO

Methapyrilene results in increased methylation of METTL8 intron

NCBI chr 3:76,140,465...76,271,367
Ensembl chr 3:76,144,178...76,271,400

G

microfibril associated protein 2

increases methylation

ISO

Methapyrilene results in increased methylation of MFAP2 intron

NCBI chr 5:158,595,121...158,603,283
Ensembl chr 5:158,597,512...158,610,656

G

milk fat globule EGF and factor V/VIII domain containing

increases methylation

ISO

Methapyrilene results in increased methylation of MFGE8 intron

NCBI chr 1:142,474,027...142,489,431
Ensembl chr 1:142,474,028...142,489,431

G

mitofusin 1

decreases expression

EXP

Methapyrilene results in decreased expression of MFN1 mRNA

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

mitofusin 2

decreases methylation

ISO

Methapyrilene results in decreased methylation of MFN2 intron

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

major facilitator superfamily domain containing 6

decreases expression

EXP

Methapyrilene results in decreased expression of MFSD6 mRNA

NCBI chr 9:56,265,152...56,350,449
Ensembl chr 9:56,265,237...56,350,446

G

MAX dimerization protein MGA

decreases expression

EXP

Methapyrilene results in decreased expression of MGA mRNA

NCBI chr 3:127,300,558...127,396,694
Ensembl chr 3:127,328,264...127,394,826

G

maltase-glucoamylase

increases methylation

ISO

Methapyrilene results in increased methylation of MGAM intron

NCBI chr 4:70,408,263...70,568,752
Ensembl chr 4:70,408,263...70,568,752

G

maltase-glucoamylase 2

increases methylation

ISO

Methapyrilene results in increased methylation of MGAM2 intron

NCBI chr 4:70,590,706...70,682,462
Ensembl chr 4:70,590,706...70,682,462

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

decreases methylation

ISO

Methapyrilene results in decreased methylation of MGAT4A intron

NCBI chr 9:47,169,229...47,282,577
Ensembl chr 9:47,169,232...47,282,574

G

monoglyceride lipase

decreases expression

EXP

Methapyrilene results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

O-6-methylguanine-DNA methyltransferase

increases expression
decreases methylation

EXP
ISO

Methapyrilene results in increased expression of MGMT mRNA
Methapyrilene results in decreased methylation of MGMT intron

PMID:15890375 PMID:21813463 PMID:30157460

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 3

decreases expression

EXP

Methapyrilene results in decreased expression of MGST3 mRNA

PMID:16393664 PMID:30467583

NCBI chr13:82,059,480...82,080,418
Ensembl chr13:82,059,480...82,080,575

G

microtubule associated monooxygenase, calponin and LIM domain containing 3

decreases expression

EXP

Methapyrilene results in decreased expression of MICAL3 mRNA

NCBI chr 4:155,824,941...156,025,003
Ensembl chr 4:155,824,946...156,005,238

G

mitochondrial calcium uptake 1

decreases methylation

ISO

Methapyrilene results in decreased methylation of MICU1 intron

NCBI chr20:28,211,774...28,357,928
Ensembl chr20:28,211,691...28,359,919

G

midline 1

decreases expression

EXP

Methapyrilene results in decreased expression of MID1 mRNA

NCBI chr X:27,678,248...28,053,049
Ensembl chr X:27,681,867...27,906,105

G

MIER family member 2

increases methylation

ISO

Methapyrilene results in increased methylation of MIER2 intron

NCBI chr 7:10,804,238...10,819,979
Ensembl chr 7:10,804,268...10,819,979

G

mitoguardin 1

increases methylation

ISO

Methapyrilene results in increased methylation of MIGA1 intron

NCBI chr 2:243,884,071...243,939,059
Ensembl chr 2:243,886,617...243,937,086

G

MINDY lysine 48 deubiquitinase 4

increases methylation

ISO

Methapyrilene results in increased methylation of MINDY4 intron; Methapyrilene results in increased methylation of MINDY4 polyA tail

NCBI chr 4:85,689,049...85,797,553
Ensembl chr 4:85,675,899...85,795,160

G

mitochondrial intermediate peptidase

decreases expression
decreases methylation

EXP
ISO

Methapyrilene results in decreased expression of MIPEP mRNA
Methapyrilene results in decreased methylation of MIPEP intron

PMID:16393664 PMID:30157460

NCBI chr15:39,102,301...39,227,915
Ensembl chr15:39,102,115...39,227,914

G

microRNA 100

affects expression

EXP

Methapyrilene affects the expression of MIR100 mRNA

NCBI chr 8:50,798,295...50,798,374
Ensembl chr 8:50,798,295...50,798,374

G

microRNA 10b

increases expression

EXP

Methapyrilene results in increased expression of MIR10B mRNA

NCBI chr 3:80,035,859...80,035,967
Ensembl chr 3:80,035,859...80,035,967

G

microRNA 122

increases expression
decreases expression

EXP
ISO

Methapyrilene results in increased expression of MIR122 mRNA
Methapyrilene results in decreased expression of MIR122 mRNA

PMID:22363424 PMID:28935588

NCBI chr18:61,028,817...61,028,901

G

microRNA 138-1

increases methylation

ISO

Methapyrilene results in increased methylation of MIR138-1 promoter

NCBI chr 8:131,178,434...131,178,532
Ensembl chr 8:131,178,434...131,178,532

G

microRNA 149

increases expression

EXP

Methapyrilene results in increased expression of MIR149 mRNA

NCBI chr 9:100,861,800...100,861,888
Ensembl chr 9:100,861,800...100,861,888

G

microRNA 150

affects expression

EXP

Methapyrilene affects the expression of MIR150 mRNA

NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571

G

microRNA 181c

decreases expression

EXP

Methapyrilene results in decreased expression of MIR181C mRNA

NCBI chr19:40,888,291...40,888,396
Ensembl chr19:40,888,291...40,888,396

G

microRNA 192

affects expression
increases expression

EXP

Methapyrilene affects the expression of MIR192 mRNA
Methapyrilene results in increased expression of MIR192 mRNA

PMID:24863736 PMID:24880025

NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:212,994,209...212,994,318

G

microRNA 196b

increases expression

EXP

Methapyrilene results in increased expression of MIR196B mRNA

NCBI chr 4:82,661,101...82,661,185

G

microRNA 19a

affects expression

EXP

Methapyrilene affects the expression of MIR19A mRNA

NCBI chr15:98,588,131...98,588,212
Ensembl chr15:98,588,131...98,588,212

G

microRNA 200a

increases expression

EXP

Methapyrilene results in increased expression of MIR200A mRNA; Methapyrilene results in increased expression of MIR200A mRNA alternative form

PMID:22363424 PMID:22584684

NCBI chr 5:171,930,717...171,930,805

G

microRNA 200c

increases expression

EXP

Methapyrilene results in increased expression of MIR200C mRNA alternative form

NCBI chr 4:159,209,965...159,210,033

G

microRNA 21

increases expression

EXP

Methapyrilene results in increased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

microRNA 210

increases expression

EXP

Methapyrilene results in increased expression of MIR210 mRNA

NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:205,755,917...205,756,034

G

microRNA 214

affects expression

EXP

Methapyrilene affects the expression of MIR214 mRNA

NCBI chr13:77,121,645...77,121,752
Ensembl chr13:77,121,643...77,121,752

G

microRNA 22

affects expression

EXP

Methapyrilene affects the expression of MIR22 mRNA

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425

G

microRNA 222

affects expression

EXP

Methapyrilene affects the expression of MIR222 mRNA

NCBI chr X:6,022,621...6,022,723
Ensembl chr X:6,022,621...6,022,723

G