|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Benzothiazoles metabolite results in increased expression of BAX mRNA |
CTD |
PMID:23339777 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Benzothiazoles metabolite results in decreased expression of BCL2 mRNA |
CTD |
PMID:23339777 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
Benzothiazoles metabolite results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:23339777 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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|
G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
decreases activity multiple interactions |
ISO |
zopolrestat results in decreased activity of AKR1B1 protein [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]; [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]; [zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant |
CTD |
PMID:21334316 |
|
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
multiple interactions decreases activity |
ISO |
zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] zopolrestat results in decreased activity of AKR1B10 protein; zopolrestat results in decreased activity of AKR1B10 protein mutant form |
CTD |
PMID:18325492 PMID:19028477 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL4 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL5 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL10 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL13 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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|
G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL4 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL5 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL6 mRNA] zopolrestat inhibits the reaction [Antigens, Plant results in increased secretion of IL6 protein] |
CTD |
PMID:21334316 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
zopolrestat results in decreased phosphorylation of and results in decreased activity of JAK2 protein |
CTD |
PMID:15746188 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] |
CTD |
PMID:24021941 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] |
CTD |
PMID:24021941 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] |
CTD |
PMID:24021941 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Stat5a |
signal transducer and activator of transcription 5A |
multiple interactions |
EXP |
zopolrestat results in decreased phosphorylation of and results in decreased activity of STAT5A protein |
CTD |
PMID:15746188 |
|
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of TNF mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein] |
CTD |
PMID:21334316 PMID:24021941 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
captax results in increased expression of AHR mRNA |
CTD |
PMID:21590714 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases activity increases expression |
ISO |
captax results in increased activity of AKR1C2 promoter captax results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 PMID:20713136 PMID:21195160 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
ISO |
captax results in increased expression of AMPD3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
captax results in increased expression of ATF3 mRNA |
CTD |
PMID:23999411 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
captax results in decreased expression of CCL2 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases secretion |
ISO |
captax results in increased secretion of CCL4 protein |
CTD |
PMID:16314067 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
increases expression |
ISO |
captax results in increased expression of CCR2 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression |
ISO |
captax results in increased expression of CCR5 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
captax results in increased expression of CD86 protein |
CTD |
PMID:12423654 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases expression |
ISO |
captax results in decreased expression of CREB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
captax results in decreased expression of CXCL14 mRNA; captax results in decreased expression of CXCL14 protein |
CTD |
PMID:31734321 |
|
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
captax results in increased expression of CXCL2 protein |
CTD |
PMID:23178550 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
captax results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
captax results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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|
G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
captax results in increased expression of DNAJB4 mRNA |
CTD |
PMID:23999411 PMID:27965148 |
|
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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|
G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
increases expression |
ISO |
captax results in increased expression of ENPP2 protein |
CTD |
PMID:22952646 |
|
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
captax results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
captax results in increased expression of FTH1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
captax results in increased expression of FTL mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
captax results in increased expression of GCLC mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
captax results in increased expression of GCLM mRNA |
CTD |
PMID:23999411 PMID:24211530 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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|
G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
captax results in increased expression of H2AX protein 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [captax results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein] |
CTD |
PMID:35279910 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
captax results in increased expression of HMOX1 mRNA |
CTD |
PMID:20713136 PMID:23445166 PMID:24211530 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
captax results in increased expression of HSPA6 mRNA |
CTD |
PMID:23999411 |
|
NCBI chr13:83,273,176...83,274,317
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|
G |
Ifng |
interferon gamma |
increases secretion |
ISO |
captax results in increased secretion of IFNG protein |
CTD |
PMID:22245253 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il18 |
interleukin 18 |
increases expression |
ISO |
captax results in increased expression of IL18 protein |
CTD |
PMID:23063874 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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|
G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
captax results in increased expression of IL1A protein captax results in increased expression of IL1A mRNA |
CTD |
PMID:23178550 PMID:33715048 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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|
G |
Il1b |
interleukin 1 beta |
increases expression increases secretion |
ISO |
captax results in increased expression of IL1B mRNA captax results in increased secretion of IL1B protein |
CTD |
PMID:33715048 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
captax results in increased secretion of IL2 protein |
CTD |
PMID:22245253 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
captax results in increased secretion of IL6 protein |
CTD |
PMID:22245253 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7r |
interleukin 7 receptor |
increases expression |
ISO |
captax results in increased expression of IL7R mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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|
G |
Mir146a |
microRNA 146a |
increases expression |
ISO |
captax results in increased expression of MIR146A mRNA |
CTD |
PMID:37326882 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
captax results in increased expression of MMP9 mRNA; captax results in increased expression of MMP9 protein |
CTD |
PMID:22952646 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
captax results in increased expression of MYC mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
affects expression |
ISO |
captax affects the expression of NFKB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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|
G |
Notch3 |
notch receptor 3 |
decreases expression |
ISO |
captax results in decreased expression of NOTCH3 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
captax results in increased expression of NQO1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
captax results in increased expression of PMAIP1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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|
G |
Rgs1 |
regulator of G-protein signaling 1 |
increases expression |
ISO |
captax results in increased expression of RGS1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984
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G |
Sel1l3 |
SEL1L family member 3 |
increases expression |
ISO |
captax results in increased expression of SEL1L3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
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G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] |
CTD |
PMID:27979590 |
|
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
captax results in increased expression of SLC7A11 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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|
G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
captax results in increased expression of SQSTM1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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|
G |
Syne2 |
spectrin repeat containing nuclear envelope protein 2 |
decreases expression |
ISO |
captax results in decreased expression of SYNE2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064
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|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
captax results in decreased expression of TNF mRNA |
CTD |
PMID:20385217 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnnt2 |
troponin T2, cardiac type |
decreases expression |
ISO |
captax results in decreased expression of TNNT2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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|
G |
Tpo |
thyroid peroxidase |
multiple interactions decreases activity |
ISO EXP |
captax binds to and results in decreased activity of TPO protein captax results in decreased activity of TPO protein |
CTD |
PMID:23959146 PMID:26865668 PMID:26884060 PMID:31629072 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
captax results in increased expression of TXNRD1 mRNA |
CTD |
PMID:23445166 PMID:24211530 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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|
G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
captax results in increased expression of VEGFA protein |
CTD |
PMID:25617811 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
affects binding |
ISO |
benzothiazole binds to AHR protein; benzothiazole metabolite binds to AHR protein |
CTD |
PMID:16705413 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
benzothiazole results in increased expression of EPHX1 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTA2 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTM1 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTM2 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein |
CTD |
PMID:12062936 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein |
CTD |
PMID:12062936 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of E 3040 analog |
CTD |
PMID:19628752 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
affects export |
ISO |
ABCG2 protein affects the export of E 3040 analog |
CTD |
PMID:15598971 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
CTD |
PMID:21272127 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Car1 |
carbonic anhydrase 1 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA1 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA2 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA3 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
lubeluzole binds to and results in decreased activity of KCNH2 protein |
CTD |
PMID:29550817 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Dihydrotestosterone inhibits the reaction [mefenacet results in increased activity of AR protein] |
CTD |
PMID:15064155 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to mefenacet |
CTD |
PMID:15853388 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
mefenacet binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in increased activity of ACHE protein] |
CTD |
PMID:35868426 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of ATP5F1A protein] |
CTD |
PMID:35868426 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] |
CTD |
PMID:16362428 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP ISO |
pramipexole binds to and results in increased activity of DRD2 protein |
CTD |
PMID:10728880 |
|
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
multiple interactions |
ISO |
pramipexole binds to and results in increased activity of DRD3 protein |
CTD |
PMID:10728880 |
|
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:16362428 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:16362428 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Pramipexole results in increased expression of PPARGC1A protein |
CTD |
PMID:35868426 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ptprd |
protein tyrosine phosphatase, receptor type, D |
increases expression |
EXP |
[Pramipexole cotreated with exercise] increases expression of Ptprd protein in the striatum |
RGD |
PMID:37633178 |
RGD:401976430 |
NCBI chr 5:90,046,993...90,698,977 NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
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G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SDHB protein] |
CTD |
PMID:35868426 |
|
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]; Riluzole promotes the reaction [AR protein binds to SQSTM1 protein]; Riluzole results in increased degradation of and results in decreased expression of AR protein; Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form; Riluzole results in increased degradation of and results in decreased expression of AR protein mutant form; STF 083010 inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] |
CTD |
PMID:30280407 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
Riluzole results in increased expression of ATF6 protein |
CTD |
PMID:30280407 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Riluzole results in increased expression of BCL2 protein |
CTD |
PMID:20885006 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] |
CTD |
PMID:19528481 PMID:22700542 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases activity |
ISO |
Riluzole results in increased activity of CASP4 protein |
CTD |
PMID:19528481 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Riluzole results in increased activity of CASP8 protein |
CTD |
PMID:19528481 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
Riluzole results in increased activity of CASP9 protein |
CTD |
PMID:19528481 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Riluzole results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Riluzole results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Glul |
glutamate-ammonia ligase |
multiple interactions |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] |
CTD |
PMID:19615351 |
|
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Riluzole results in increased expression of HSPA5 protein |
CTD |
PMID:30280407 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation |
EXP |
Riluzole results in decreased phosphorylation of JUN protein |
CTD |
PMID:10067977 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
decreases expression |
ISO |
Riluzole results in decreased expression of KLK3 mRNA |
CTD |
PMID:30280407 |
|
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Nefh |
neurofilament heavy chain |
decreases phosphorylation |
EXP |
Riluzole results in decreased phosphorylation of NEFH protein |
CTD |
PMID:19429076 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nefm |
neurofilament medium chain |
affects localization decreases phosphorylation |
EXP |
Riluzole affects the localization of NEFM protein Riluzole results in decreased phosphorylation of NEFM protein |
CTD |
PMID:19429076 |
|
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
Riluzole results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] |
CTD |
PMID:16303979 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Slc17a7 |
solute carrier family 17 member 7 |
decreases expression |
EXP |
Riluzole results in decreased expression of SLC17A7 protein |
CTD |
PMID:17507170 |
|
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions increases expression |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA] Riluzole results in increased expression of SLC1A2 mRNA; Riluzole results in increased expression of SLC1A2 protein |
CTD |
PMID:19615351 PMID:22966415 |
|
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc1a3 |
solute carrier family 1 member 3 |
multiple interactions increases expression |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA] Riluzole results in increased expression of SLC1A3 mRNA; Riluzole results in increased expression of SLC1A3 protein |
CTD |
PMID:19615351 PMID:22966415 |
|
NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Riluzole promotes the reaction [AR protein binds to SQSTM1 protein] |
CTD |
PMID:30280407 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Utrn |
utrophin |
increases expression |
ISO |
Riluzole results in increased expression of UTRN mRNA |
CTD |
PMID:22028826 |
|
NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] |
CTD |
PMID:16303979 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
Riluzole results in increased expression of XBP1 protein |
CTD |
PMID:30280407 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2D6 protein results in increased metabolism of sabeluzole |
CTD |
PMID:11259989 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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|
G |
Afp |
alpha-fetoprotein |
increases expression |
ISO |
Saccharin results in increased expression of AFP mRNA |
CTD |
PMID:26272751 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Car13 |
carbonic anhydrase 13 |
increases expression |
ISO |
Saccharin results in increased expression of CAR13 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525
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G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
Saccharin binds to and results in decreased activity of CA3 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
ISO |
Saccharin results in increased expression of CDK1 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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|
G |
Cer1 |
cerberus 1, DAN family BMP antagonist |
increases expression |
ISO |
Saccharin results in increased expression of CER1 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783
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|
G |
Chek1 |
checkpoint kinase 1 |
increases expression |
ISO |
Saccharin results in increased expression of CHEK1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of FOSL1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Gnat3 |
G protein subunit alpha transducin 3 |
affects response to substance |
ISO |
GNAT3 protein affects the susceptibility to Saccharin |
CTD |
PMID:16740645 |
|
NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
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|
G |
Hdac7 |
histone deacetylase 7 |
decreases expression |
ISO |
Saccharin results in decreased expression of HDAC7 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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|
G |
Hells |
helicase, lymphoid specific |
increases expression |
ISO |
Saccharin results in increased expression of HELLS mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
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|
G |
Il1rl1 |
interleukin 1 receptor-like 1 |
increases expression |
ISO |
Saccharin results in increased expression of IL1RL1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of JUN mRNA |
CTD |
PMID:19000923 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of JUNB mRNA |
CTD |
PMID:19000923 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Kdr |
kinase insert domain receptor |
increases expression |
ISO |
Saccharin results in increased expression of KDR mRNA |
CTD |
PMID:26272751 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Mcm3 |
minichromosome maintenance complex component 3 |
increases expression |
ISO |
Saccharin results in increased expression of MCM3 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
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G |
Mesp1 |
mesoderm posterior bHLH transcription factor 1 |
decreases expression |
ISO |
Saccharin results in decreased expression of MESP1 mRNA |
CTD |
PMID:26272751 |
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NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Saccharin results in increased expression of MYC mRNA |
CTD |
PMID:26272751 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myo1e |
myosin IE |
increases expression |
ISO |
Saccharin results in increased expression of MYO1E mRNA |
CTD |
PMID:26272751 |
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NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
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Nes |
nestin |
increases expression |
ISO |
Saccharin results in increased expression of NES mRNA |
CTD |
PMID:26272751 |
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NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
ISO |
Saccharin results in increased expression of NOS2 mRNA |
CTD |
PMID:28472674 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nup54 |
nucleoporin 54 |
increases expression |
ISO |
Saccharin results in increased expression of NUP54 mRNA |
CTD |
PMID:19000923 |
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NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
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G |
Orm1 |
orosomucoid 1 |
increases expression |
ISO |
Saccharin results in increased expression of ORM1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Phex |
phosphate regulating endopeptidase X-linked |
increases expression |
ISO |
Saccharin results in increased expression of PHEX mRNA |
CTD |
PMID:19000923 |
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NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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G |
Pik3r5 |
phosphoinositide-3-kinase, regulatory subunit 5 |
increases expression |
ISO |
Saccharin results in increased expression of PIK3R5 mRNA |
CTD |
PMID:19000923 |
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NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
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G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases expression |
ISO |
Saccharin results in decreased expression of PNPLA6 mRNA |
CTD |
PMID:26272751 |
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NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Saccharin co-treated with Glucose] binds to PPARA protein; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Rad21 |
RAD21 cohesin complex component |
increases expression |
ISO |
Saccharin results in increased expression of RAD21 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
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Rif1 |
replication timing regulatory factor 1 |
increases expression |
ISO |
Saccharin results in increased expression of RIF1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
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Scarb1 |
scavenger receptor class B, member 1 |
increases expression |
ISO |
Saccharin results in increased expression of SCARB1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Shh |
sonic hedgehog signaling molecule |
decreases expression |
ISO |
Saccharin results in decreased expression of SHH mRNA |
CTD |
PMID:26272751 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Saccharin results in increased expression of SLC2A1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Stmn1 |
stathmin 1 |
increases expression |
ISO |
Saccharin results in increased expression of STMN1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Tas1r3 |
taste 1 receptor member 3 |
affects response to substance multiple interactions |
ISO |
TAS1R3 protein affects the susceptibility to Saccharin TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin] |
CTD |
PMID:18804451 |
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NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742
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Tas2r136 |
taste receptor, type 2, member 136 |
increases activity |
ISO |
Saccharin results in increased activity of TAS2R31 protein |
CTD |
PMID:21629661 |
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NCBI chr 4:166,098,848...166,099,840
Ensembl chr 4:166,098,848...166,099,840
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Tfrc |
transferrin receptor |
increases expression |
ISO |
Saccharin results in increased expression of TFRC mRNA |
CTD |
PMID:19000923 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tnf |
tumor necrosis factor |
increases expression |
ISO |
Saccharin results in increased expression of TNF mRNA |
CTD |
PMID:28472674 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions increases activity |
ISO |
TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin] Saccharin results in increased activity of TRPV1 protein |
CTD |
PMID:17567713 PMID:18804451 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
Saccharin results in increased expression of VEGFA mRNA |
CTD |
PMID:19000923 PMID:26272751 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Wnt3 |
Wnt family member 3 |
increases expression |
ISO |
Saccharin results in increased expression of WNT3 mRNA |
CTD |
PMID:26272751 |
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NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
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Alb |
albumin |
multiple interactions affects binding |
EXP ISO |
ziprasidone results in decreased expression of and results in increased reduction of ALB protein ziprasidone binds to ALB protein [ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein] |
CTD |
PMID:31400341 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Cat |
catalase |
increases expression |
EXP |
ziprasidone results in increased expression of CAT mRNA |
CTD |
PMID:32937854 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
ziprasidone results in increased expression of HMGCR mRNA |
CTD |
PMID:17052361 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
ziprasidone results in increased expression of HMGCS1 mRNA |
CTD |
PMID:17052361 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
ziprasidone results in increased expression of HMOX1 mRNA |
CTD |
PMID:32937854 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP |
[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone |
CTD |
PMID:15996562 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions |
ISO |
ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] |
CTD |
PMID:16314884 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
ziprasidone results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
ziprasidone results in increased expression of NQO1 mRNA |
CTD |
PMID:32937854 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
ISO |
ziprasidone results in increased expression of SC5D mRNA |
CTD |
PMID:17052361 |
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NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:30465787 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Sox17 |
SRY-box transcription factor 17 |
decreases localization |
ISO |
ziprasidone results in decreased localization of SOX17 protein |
CTD |
PMID:24154490 |
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NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
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