thienopyridine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thienopyridine	go back to main search page
Accession:	CHEBI:37942	browse the term
Definition:	Any organic heterobicyclic compound whose skeleton results from the formal ortho-fusion of any bond of a pyridine with any bond of a thiophene.
Synonyms:	related_synonym:	thienopyridines

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Genes (84)

clopidogrel

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases uptake
decreases expression
increases secretion
decreases activity
affects response to substance

ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]
[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel
ABCB1 protein results in decreased uptake of clopidogrel
clopidogrel results in decreased expression of ABCB1 mRNA; clopidogrel results in decreased expression of ABCB1 protein
ABCB1 protein results in increased secretion of clopidogrel
clopidogrel results in decreased activity of ABCB1 protein
ABCB1 gene affects the susceptibility to clopidogrel; ABCB1 gene polymorphism affects the susceptibility to clopidogrel; ABCB1 gene SNP affects the susceptibility to clopidogrel

PMID:17112805 PMID:19106083 PMID:19934793 PMID:20180610 PMID:21900887

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA]

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

Rho GTPase activating protein 31

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGAP31 mRNA]

NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564

G

brain-derived neurotrophic factor

decreases secretion

clopidogrel results in decreased secretion of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

complement C4B

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA]

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

calcineurin binding protein 1

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CABIN1 mRNA]

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcium/calmodulin-dependent protein kinase kinase 2

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA]

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

C-C motif chemokine ligand 11

increases expression

clopidogrel results in increased expression of CCL11 mRNA

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 4

increases expression

clopidogrel results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression

clopidogrel results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD40 ligand

multiple interactions
decreases expression

clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
clopidogrel results in decreased expression of CD40LG protein
Clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD40LG protein]

PMID:11297035 PMID:17043144 PMID:19155974 PMID:30537341

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD86 molecule

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

chloride voltage-gated channel 7

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CLCN7 mRNA]

NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130

G

colony stimulating factor 2 receptor subunit beta

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2RB mRNA]

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Clopidogrel results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases oxidation

CYP1A2 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; furafylline inhibits the reaction [CYP1A2 protein results in increased oxidation of Clopidogrel]
CYP1A2 protein results in increased oxidation of clopidogrel

PMID:19170597 PMID:19812348

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Clopidogrel results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases oxidation
increases expression
multiple interactions

CYP2B6 protein results in increased oxidation of clopidogrel
Clopidogrel results in increased expression of CYP2B6 mRNA
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA

PMID:19812348 PMID:31312845

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases oxidation
increases metabolic processing
decreases response to substance
increases response to substance
decreases metabolic processing
affects abundance
affects response to substance

ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
CYP2C19 protein results in increased metabolism of clopidogrel
CYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrel
CYP2C19 gene polymorphism affects the abundance of clopidogrel metabolite
CYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrel

PMID:16772608 PMID:17697139 PMID:17900275 PMID:18532997 PMID:18577829 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

multiple interactions

CYP2C8 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases response to substance
increases degradation
affects response to substance
multiple interactions

Clopidogrel results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Clopidogrel
CYP3A4 protein results in increased degradation of Clopidogrel
CYP3A4 gene polymorphism affects the susceptibility to Clopidogrel
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]

PMID:16645157 PMID:19170597 PMID:22651985 PMID:31312845

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects response to substance
multiple interactions

CYP3A5 gene polymorphism affects the susceptibility to clopidogrel
CYP3A5 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite

PMID:16754899 PMID:19170597

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

dual specificity phosphatase 1

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 mRNA]

NCBI chr10:16,680,478...16,683,275

G

eukaryotic translation initiation factor 1A

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of EIF1A mRNA]

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

coagulation factor II, thrombin

multiple interactions

clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

affects response to substance

F2R gene SNP affects the susceptibility to clopidogrel

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

coagulation factor III, tissue factor

multiple interactions

Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Clopidogrel results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

intercellular adhesion molecule 1

decreases expression

clopidogrel results in decreased expression of ICAM1 mRNA; clopidogrel results in decreased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10 receptor subunit alpha

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA]

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 13

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions

Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

increases expression

clopidogrel results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
decreases expression
increases response to substance

clopidogrel promotes the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]
clopidogrel results in decreased expression of IL6 mRNA
IL6 protein results in increased susceptibility to clopidogrel
clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:17537833 PMID:19155974 PMID:24793913 PMID:24849676

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 2

multiple interactions

ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]

PMID:15205592 PMID:16214444

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit beta 3

decreases response to substance
affects response to substance

ITGB3 gene SNP results in decreased susceptibility to clopidogrel
ITGB3 gene SNP affects the susceptibility to clopidogrel

PMID:15166949 PMID:19530321

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

leukotriene B4 receptor

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA]

NCBI chr15:29,263,199...29,265,716

G

mitogen activated protein kinase 3

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 mRNA]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

methylcrotonyl-CoA carboxylase subunit 2

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA]

NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972

G

mediator complex subunit 1

multiple interactions

Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]

NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299

G

microRNA 155

increases expression

Clopidogrel results in increased expression of MIR155 mRNA

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 17

decreases expression

Clopidogrel results in decreased expression of MIR17 mRNA

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

G

microRNA 363

increases expression

Clopidogrel results in increased expression of MIR363 mRNA

NCBI chr X:132,421,791...132,421,877
Ensembl chr X:132,421,791...132,421,877

G

matrix metallopeptidase 9

decreases activity

clopidogrel results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

Clopidogrel inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

PMID:20133375 PMID:30537341

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear receptor subfamily 1, group I, member 3

affects localization
multiple interactions

Clopidogrel affects the localization of NR1I3 protein mutant form
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Clopidogrel binds to and results in increased activity of NR1I3 protein alternative form; Clopidogrel inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

occludin

decreases expression
multiple interactions

clopidogrel results in decreased expression of OCLN protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

purinergic receptor P2Y12

multiple interactions
increases response to substance
affects response to substance

clopidogrel binds to and results in decreased activity of P2RY12 protein; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
P2RY12 protein results in increased susceptibility to clopidogrel
P2RY12 gene affects the susceptibility to clopidogrel; P2RY12 gene SNP affects the susceptibility to clopidogrel; P2RY12 protein affects the susceptibility to clopidogrel

PMID:11413167 PMID:15933261 PMID:18404433 PMID:18485500 PMID:18577829 More...

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

phosphoenolpyruvate carboxykinase 1

increases expression

Clopidogrel results in increased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

platelet derived growth factor subunit B

decreases expression

clopidogrel results in decreased expression of PDGFB mRNA; clopidogrel results in decreased expression of PDGFB protein

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

paraoxonase 1

affects response to substance
multiple interactions

PON1 gene polymorphism affects the susceptibility to clopidogrel
PON1 protein results in increased metabolism of and results in increased activity of clopidogrel

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein kinase C, beta

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

RAN, member RAS oncogene family

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA]

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

S100 calcium binding protein A11

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of S100A11 mRNA]

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

stearoyl-CoA desaturase

decreases expression

Clopidogrel results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

selectin E

decreases expression

clopidogrel results in decreased expression of SELE mRNA; clopidogrel results in decreased expression of SELE protein

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selectin P

multiple interactions
decreases expression

Clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]
clopidogrel results in decreased expression of SELP mRNA; clopidogrel results in decreased expression of SELP protein

PMID:17043144 PMID:19155974 PMID:30537341

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

solute carrier family 3 member 1

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SLC3A1 mRNA]

NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907

G

signal transducer and activator of transcription 2

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA]

NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967

G

succinate-CoA ligase ADP-forming subunit beta

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA]

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

transforming growth factor, beta 1

multiple interactions
increases expression

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
clopidogrel results in increased expression of TGFB1 mRNA

PMID:19155974 PMID:19172522

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thrombospondin 1

increases expression

clopidogrel results in increased expression of THBS1; clopidogrel results in increased expression of THBS1 mRNA; clopidogrel results in increased expression of THBS1 protein

PMID:9447704 PMID:11875746

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone responsive

increases expression

Clopidogrel results in increased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

tight junction protein 1

decreases expression
multiple interactions

clopidogrel results in decreased expression of TJP1 protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transmembrane protein 69

multiple interactions

clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TMEM69 mRNA]

NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655

G

tumor necrosis factor

increases expression
multiple interactions

clopidogrel results in increased expression of TNF mRNA
Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:19155974 PMID:30537341

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

clopidogrel results in increased expression of TP53 mRNA; clopidogrel results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vasodilator-stimulated phosphoprotein

multiple interactions

CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

ticlopidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
decreases expression

Ticlopidine results in decreased activity of ABCB11 protein
Ticlopidine results in decreased expression of ABCB11 mRNA

PMID:22646477 PMID:27765674

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

decreases activity
increases expression

Ticlopidine results in decreased activity of ABCC2 protein
Ticlopidine results in increased expression of ABCC2 mRNA

PMID:22646477 PMID:27765674

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Ticlopidine results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

Ticlopidine results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

caspase 3

increases activity
multiple interactions

Ticlopidine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Ticlopidine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

collagen type XVIII alpha 1 chain

increases expression

Ticlopidine results in increased expression of COL18A1 protein

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

CYP1A2 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP1A2 protein

PMID:10759690 PMID:19053182 PMID:19170597

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Ticlopidine results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases activity

Ticlopidine binds to and results in decreased activity of CYP2B6 protein; Ticlopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]; Ticlopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Ticlopidine results in decreased activity of CYP2B6 protein

PMID:16855053 PMID:19328226 PMID:23850985 PMID:28887089 PMID:33253783

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

CYP2C19 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP2C19 protein]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP2C19 protein

PMID:10759690 PMID:15333513 PMID:15860655 PMID:16049126 PMID:19053182 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

multiple interactions

CYP2C8 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases activity

CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite
Ticlopidine results in decreased activity of CYP2D6 protein

PMID:10759690 PMID:19170597

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases degradation
increases response to substance
multiple interactions

CYP3A4 protein results in increased degradation of Ticlopidine
CYP3A4 protein results in increased susceptibility to Ticlopidine
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

PMID:19170597 PMID:19299527 PMID:22651985

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions

CYP3A5 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

heme oxygenase 1

multiple interactions
increases expression

1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

progesterone receptor

multiple interactions

Ticlopidine binds to and results in decreased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

RT1 class I, locus CE16

affects response to substance

HLA-A gene polymorphism affects the susceptibility to Ticlopidine

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

solute carrier family 10 member 1

decreases expression

Ticlopidine results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 47 member 1

multiple interactions

Ticlopidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Ticlopidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

thrombospondin 1

affects expression

Ticlopidine affects the expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

UDP glucuronosyltransferase family 1 member A1

increases expression

Ticlopidine results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

decreases activity

Ticlopidine results in decreased activity of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
chemical entity	19878
atom	19878
nonmetal atom	19800
nitrogen atom	18979
nitrogen molecular entity	18979
organonitrogen compound	18833
organonitrogen heterocyclic compound	18153
thienopyridine	84
1-(3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinyl)ethanone	0
1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester	0
2-(1-oxopropylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-(3-fluoroanilino)-7-hydroxy-5-oxo-4H-thieno[3,2-b]pyridine-3-carbonitrile	0
2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole	0
2-(4-tert-butylphenyl)sulfinyl-4,6-dimethyl-3-thieno[2,3-b]pyridinamine	0
2-(6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole	0
2-Chloroticlopidine	0
2-[[(2,5-dichloro-3-thiophenyl)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	0
2-[[1-oxo-2-(2-pyrimidinylthio)ethyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-[[2-(2-cyanophenoxy)-1-oxoethyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-[[3-(benzenesulfonyl)-1-oxopropyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-acetamido-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester	0
3-(dimethylaminomethylideneamino)-4-methoxy-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid methyl ester	0
3-amino-4,6-dimethyl-N-(thiophen-2-ylmethylideneamino)-2-thieno[2,3-b]pyridinecarboxamide	0
3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl ester	0
3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide	0
4-(dimethylamino)-3-[(phenylmethoxyamino)methylideneamino]-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester	0
4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine	0
4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester	0
5,5,7,7-tetramethyl-2-[[oxo-(4-propan-2-yloxyphenyl)methyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid methyl ester	0
5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate +	0
6-methyl-2-[(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
7-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl-(phenylmethyl)amino]methyl]-4-oxo-5-thieno[2,3-b]pyridinecarboxylic acid propan-2-yl ester	0
7-hydroxyticlopidine	0
IWP-2	0
LSM-16789	0
LSM-19448	0
LSM-32991	0
N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxybenzamide	0
N-[(3S)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]acetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide	0
N-[3-(1,3-benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(2-benzofuranyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(4-phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide	0
N-[6-acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide	0
R-95913	0
Thieno[2,3-b]pyridine-2-carboxylic acid	0
Thienodihydropyridinium	0
Tinoridine hydrochloride	0
[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-cyclopropylmethanone	0
clopidogrel +	69
clopidogrel carboxylic acid	0
diethyl 3-amino-6-methylthieno[2,3-b]pyridine-2,5-dicarboxylate	0
ticlopidine +	84
tinoridine	0
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
p-block element atom	19817
carbon group element atom	19757
carbon atom	19754
organic molecular entity	19754
organic molecule	19706
organic cyclic compound	19495
organic heterocyclic compound	18874
organic heteropolycyclic compound	18300
organic heterobicyclic compound	17242
thienopyridine	84
1-(3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinyl)ethanone	0
1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester	0
2-(1-oxopropylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-(3-fluoroanilino)-7-hydroxy-5-oxo-4H-thieno[3,2-b]pyridine-3-carbonitrile	0
2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole	0
2-(4-tert-butylphenyl)sulfinyl-4,6-dimethyl-3-thieno[2,3-b]pyridinamine	0
2-(6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole	0
2-Chloroticlopidine	0
2-[[(2,5-dichloro-3-thiophenyl)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	0
2-[[1-oxo-2-(2-pyrimidinylthio)ethyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-[[2-(2-cyanophenoxy)-1-oxoethyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-[[3-(benzenesulfonyl)-1-oxopropyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
2-acetamido-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester	0
3-(dimethylaminomethylideneamino)-4-methoxy-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid methyl ester	0
3-amino-4,6-dimethyl-N-(thiophen-2-ylmethylideneamino)-2-thieno[2,3-b]pyridinecarboxamide	0
3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl ester	0
3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide	0
4-(dimethylamino)-3-[(phenylmethoxyamino)methylideneamino]-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	0
4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester	0
4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine	0
4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester	0
5,5,7,7-tetramethyl-2-[[oxo-(4-propan-2-yloxyphenyl)methyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid methyl ester	0
5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate +	0
6-methyl-2-[(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester	0
7-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl-(phenylmethyl)amino]methyl]-4-oxo-5-thieno[2,3-b]pyridinecarboxylic acid propan-2-yl ester	0
7-hydroxyticlopidine	0
IWP-2	0
LSM-16789	0
LSM-19448	0
LSM-32991	0
N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxybenzamide	0
N-[(3S)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]acetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide	0
N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide	0
N-[3-(1,3-benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(2-benzofuranyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-(4-phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide	0
N-[6-acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	0
N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide	0
R-95913	0
Thieno[2,3-b]pyridine-2-carboxylic acid	0
Thienodihydropyridinium	0
Tinoridine hydrochloride	0
[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-cyclopropylmethanone	0
clopidogrel +	69
clopidogrel carboxylic acid	0
diethyl 3-amino-6-methylthieno[2,3-b]pyridine-2,5-dicarboxylate	0
ticlopidine +	84
tinoridine	0

paths to the root