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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridazines
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Accession:CHEBI:37921 term browser browse the term
Synonyms:xref_mesh: MESH:D011724


show annotations for term's descendants           Sort by:
pyridazines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Pyridazines analog binds to and results in decreased activity of MCHR1 protein] which results in decreased phosphorylation of MAPK1 protein CTD PMID:16987592 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Pyridazines analog binds to and results in decreased activity of MCHR1 protein] which results in decreased phosphorylation of MAPK3 protein CTD PMID:16987592 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mchr1 melanin-concentrating hormone receptor 1 multiple interactions ISO [Pyridazines analog binds to and results in decreased activity of MCHR1 protein] which results in decreased phosphorylation of MAPK1 protein; [Pyridazines analog binds to and results in decreased activity of MCHR1 protein] which results in decreased phosphorylation of MAPK3 protein; Pyridazines analog binds to and results in decreased activity of MCHR1 protein CTD PMID:16987592 NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032 		JBrowse link
Maleic hydrazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity ISO Maleic Hydrazide results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases activity ISO Maleic Hydrazide results in decreased activity of IMPDH2 protein CTD PMID:11370715 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:15853388 PMID:16608219 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
omipalisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein
omipalisib results in decreased phosphorylation of AKT1 protein		 CTD PMID:22733540 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein CTD PMID:22733540 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of BECN1 protein] CTD PMID:36125241 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of CASP3 protein modified form] CTD PMID:22733540 PMID:36125241 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein CTD PMID:22733540 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO omipalisib enhances the reaction [DDR1-IN-1 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines]] RGD PMID:23899692 RGD:152995467 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased expression of EGFR protein] CTD PMID:36125241 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:22733540 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib] CTD PMID:22733540 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib] CTD PMID:22733540 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein
omipalisib results in increased phosphorylation of MAPK1 protein		 CTD PMID:22733540 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein
omipalisib results in increased phosphorylation of MAPK3 protein		 CTD PMID:22733540 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:36125241 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases phosphorylation
increases cleavage		 ISO omipalisib results in decreased phosphorylation of PARP1 protein
omipalisib results in increased cleavage of PARP1 protein		 CTD PMID:21464613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of RPS6 protein CTD PMID:21464613 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 PMID:22733540 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
pimobendan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO pimobendan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
pimobendan results in decreased expression of IL1B protein		 CTD PMID:9004165 PMID:10193745 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO pimobendan results in decreased expression of IL6 protein
pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:9004165 PMID:10193745 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP pimobendan promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:9492047 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pimobendan results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO pimobendan results in decreased expression of NOS2 mRNA
[pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide		 CTD PMID:10193745 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
pimobendan results in decreased expression of TNF protein		 CTD PMID:9004165 PMID:10193745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
pyridaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco2 aconitase 2 decreases activity EXP pyridaben results in decreased activity of ACO2 protein CTD PMID:26141520 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Adam22 ADAM metallopeptidase domain 22 increases expression ISO pyridaben results in increased expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases expression ISO pyridaben results in increased expression of ADCYAP1 mRNA CTD PMID:22563483 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 increases expression ISO pyridaben results in increased expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Amn amnion associated transmembrane protein decreases expression ISO pyridaben results in decreased expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815 		JBrowse link
G Ar androgen receptor multiple interactions ISO pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atoh7 atonal bHLH transcription factor 7 decreases expression ISO pyridaben results in decreased expression of ATOH7 mRNA CTD PMID:22563483 NCBI chr20:25,530,826...25,531,275
Ensembl chr20:25,530,826...25,531,275 		JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases expression ISO pyridaben results in increased expression of ATP8A2 mRNA CTD PMID:22563483 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions		 ISO BCL2 protein results in decreased susceptibility to pyridaben
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]		 CTD PMID:12730627 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO pyridaben results in increased expression of BCL2A1 mRNA CTD PMID:22563483 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bicd1 BICD cargo adaptor 1 increases expression ISO pyridaben results in increased expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434 		JBrowse link
G C2cd4d C2 calcium-dependent domain containing 4D decreases expression ISO pyridaben results in decreased expression of C2CD4D mRNA CTD PMID:22563483 NCBI chr 2:181,999,778...182,001,941
Ensembl chr 2:181,997,078...182,002,087 		JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated increases expression ISO pyridaben results in increased expression of CABYR mRNA CTD PMID:22563483 NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases expression ISO pyridaben results in increased expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO pyridaben results in increased expression of CAMP mRNA CTD PMID:22563483 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Capn11 calpain 11 decreases expression ISO pyridaben results in decreased expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601 		JBrowse link
G Casp3 caspase 3 increases expression EXP pyridaben results in increased expression of CASP3 mRNA; pyridaben results in increased expression of CASP3 protein CTD PMID:37357870 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO pyridaben results in increased expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO pyridaben results in increased expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 increases expression ISO pyridaben results in increased expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Cdhr4 cadherin-related family member 4 decreases expression ISO pyridaben results in decreased expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 8:108,682,594...108,690,358
Ensembl chr 8:108,682,613...108,690,367 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO pyridaben results in decreased expression of CEBPD mRNA CTD PMID:22563483 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO pyridaben results in increased expression of CEP290 mRNA CTD PMID:22563483 NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392 		JBrowse link
G Cldn3 claudin 3 decreases expression ISO pyridaben results in decreased expression of CLDN3 mRNA CTD PMID:22563483 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 decreases expression ISO pyridaben results in decreased expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642 		JBrowse link
G Dgki diacylglycerol kinase, iota increases expression ISO pyridaben results in increased expression of DGKI mRNA CTD PMID:22563483 NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733 		JBrowse link
G Dip2b disco-interacting protein 2 homolog B increases expression ISO pyridaben results in increased expression of DIP2B mRNA CTD PMID:22563483 NCBI chr 7:131,174,575...131,350,417
Ensembl chr 7:131,174,567...131,349,092 		JBrowse link
G Dmrta2 DMRT-like family A2 decreases expression ISO pyridaben results in decreased expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630 		JBrowse link
G Drd4 dopamine receptor D4 decreases expression ISO pyridaben results in decreased expression of DRD4 mRNA CTD PMID:22563483 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Egr4 early growth response 4 decreases expression ISO pyridaben results in decreased expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328 		JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO pyridaben results in increased expression of ELANE mRNA CTD PMID:22563483 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions		 ISO pyridaben results in increased activity of ESR1 protein
pyridaben binds to and results in increased activity of ESR1 protein; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]		 CTD PMID:20143881 PMID:30818834 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; pyridaben inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Etl4 enhancer trap locus 4 increases expression ISO pyridaben results in increased expression of ETL4 mRNA CTD PMID:22563483 NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715 		JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO pyridaben results in decreased expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr17:42,470,593...42,478,590 JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO pyridaben results in decreased expression of H3C1 mRNA CTD PMID:22563483 NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO pyridaben results in decreased expression of HMX3 mRNA CTD PMID:22563483 NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201 		JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 decreases expression ISO pyridaben results in decreased expression of HS3ST6 mRNA CTD PMID:22563483 NCBI chr10:13,781,999...13,788,133
Ensembl chr10:13,781,993...13,788,133 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO pyridaben results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Il6 interleukin 6 increases expression EXP pyridaben results in increased expression of IL6 mRNA CTD PMID:37357870 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pyridaben results in increased expression of INHBA mRNA CTD PMID:22563483 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Insl3 insulin-like 3 decreases expression ISO pyridaben results in decreased expression of INSL3 mRNA CTD PMID:22563483 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Itgb8 integrin subunit beta 8 increases expression ISO pyridaben results in increased expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 increases expression ISO pyridaben results in increased expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 increases expression ISO pyridaben results in increased expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kif1b kinesin family member 1B increases expression ISO pyridaben results in increased expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Klf2 KLF transcription factor 2 decreases expression ISO pyridaben results in decreased expression of KLF2 mRNA CTD PMID:22563483 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Klhl15 kelch-like family member 15 increases expression ISO pyridaben results in increased expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO pyridaben results in increased expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO pyridaben results in increased expression of LIFR mRNA CTD PMID:22563483 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lrp4 LDL receptor related protein 4 increases expression ISO pyridaben results in increased expression of LRP4 mRNA CTD PMID:22563483 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Lrrc63 leucine rich repeat containing 63 decreases expression ISO pyridaben results in decreased expression of LRRC63 mRNA CTD PMID:22563483 NCBI chr15:50,400,199...50,437,321
Ensembl chr15:50,400,200...50,437,321 		JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 decreases expression ISO pyridaben results in decreased expression of LTB4R2 mRNA CTD PMID:22563483 NCBI chr15:29,258,712...29,260,531
Ensembl chr15:29,259,240...29,260,316 		JBrowse link
G Ltf lactotransferrin increases expression ISO pyridaben results in increased expression of LTF mRNA CTD PMID:22563483 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Mapk15 mitogen-activated protein kinase 15 decreases expression ISO pyridaben results in decreased expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645 		JBrowse link
G Marchf9 membrane associated ring-CH-type finger 9 decreases expression ISO pyridaben results in decreased expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr 7:62,879,017...62,882,495
Ensembl chr 7:62,879,018...62,882,495 		JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 increases expression ISO pyridaben results in increased expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485 		JBrowse link
G Mdfi MyoD family inhibitor decreases expression ISO pyridaben results in decreased expression of MDFI mRNA CTD PMID:22563483 NCBI chr 9:13,156,806...13,175,218
Ensembl chr 9:13,156,866...13,175,217 		JBrowse link
G Mpo myeloperoxidase increases expression ISO pyridaben results in increased expression of MPO mRNA CTD PMID:22563483 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrtfb myocardin related transcription factor B increases expression ISO pyridaben results in increased expression of MRTFB mRNA CTD PMID:22563483 NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897 		JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming increases expression ISO pyridaben results in increased expression of MUC6 mRNA CTD PMID:22563483 NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842 		JBrowse link
G Myoc myocilin increases expression ISO pyridaben results in increased expression of MYOC mRNA CTD PMID:22563483 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO pyridaben results in increased expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO pyridaben results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfib nuclear factor I/B increases expression ISO pyridaben results in increased expression of NFIB mRNA CTD PMID:22563483 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO pyridaben results in increased expression of NIPBL mRNA CTD PMID:22563483 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 decreases response to substance ISO NMNAT3 protein results in decreased susceptibility to pyridaben CTD PMID:18463239 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Nps neuropeptide S increases expression ISO pyridaben results in increased expression of NPS mRNA CTD PMID:22563483 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyridaben binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO pyridaben results in decreased expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 ISO pyridaben inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
pyridaben results in increased activity of ODC1 protein		 CTD PMID:9834970 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases expression ISO pyridaben results in decreased expression of OXT mRNA CTD PMID:22563483 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases response to substance ISO PARK7 protein results in decreased susceptibility to pyridaben CTD PMID:21219333 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO pyridaben results in increased cleavage of PARP1 protein
[pyridaben co-treated with Paraquat] results in increased cleavage of PARP1 protein		 CTD PMID:16237197 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phox2a paired-like homeobox 2a decreases expression ISO pyridaben results in decreased expression of PHOX2A mRNA CTD PMID:22563483 NCBI chr 1:156,178,754...156,183,118
Ensembl chr 1:156,178,754...156,183,118 		JBrowse link
G Plce1 phospholipase C, epsilon 1 increases expression ISO pyridaben results in increased expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pyridaben binds to and results in increased activity of PPARG protein; pyridaben inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO pyridaben results in increased expression of PPARGC1A mRNA
pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]		 CTD PMID:22563483 PMID:30818834 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prr7 proline rich 7 (synaptic) decreases expression ISO pyridaben results in decreased expression of PRR7 mRNA CTD PMID:22563483 NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536 		JBrowse link
G Retnlb resistin like beta increases expression ISO pyridaben results in increased expression of RETNLB mRNA CTD PMID:22563483 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression ISO pyridaben results in increased expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO pyridaben results in increased expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO pyridaben results in increased expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO pyridaben results in decreased expression of SHOX2 mRNA CTD PMID:22563483 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO pyridaben results in increased expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Smoc2 SPARC related modular calcium binding 2 increases expression ISO pyridaben results in increased expression of SMOC2 mRNA CTD PMID:22563483 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693 		JBrowse link
G Snca synuclein alpha increases response to substance ISO SNCA protein results in increased susceptibility to pyridaben CTD PMID:16239214 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO pyridaben results in decreased expression of SOCS1 mRNA CTD PMID:22563483 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Ston2 stonin 2 increases expression ISO pyridaben results in increased expression of STON2 mRNA CTD PMID:22563483 NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO pyridaben results in increased expression of STRBP mRNA CTD PMID:22563483 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949 		JBrowse link
G Tbck TBC1 domain containing kinase increases expression ISO pyridaben results in increased expression of TBCK mRNA CTD PMID:22563483 NCBI chr 2:221,175,749...221,348,058
Ensembl chr 2:221,175,785...221,348,126 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO pyridaben results in decreased expression of TCF15 mRNA CTD PMID:22563483 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO pyridaben binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tmem42 transmembrane protein 42 decreases expression ISO pyridaben results in decreased expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO pyridaben results in increased expression of TNNT2 mRNA CTD PMID:22563483 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 increases expression ISO pyridaben results in increased expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717 		JBrowse link
G Tusc1 tumor suppressor candidate 1 decreases expression ISO pyridaben results in decreased expression of TUSC1 mRNA CTD PMID:22563483 NCBI chr 5:108,089,952...108,091,315
Ensembl chr 5:108,090,613...108,091,224 		JBrowse link
G Ubxn7 UBX domain protein 7 increases expression ISO pyridaben results in increased expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr11:68,427,896...68,460,100 JBrowse link
G Ucn urocortin decreases expression ISO pyridaben results in decreased expression of UCN mRNA CTD PMID:22563483 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
G Unc13c unc-13 homolog C increases expression ISO pyridaben results in increased expression of UNC13C mRNA CTD PMID:22563483 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
G Vdr vitamin D receptor increases activity ISO pyridaben results in increased activity of VDR protein CTD PMID:20143881 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 increases expression ISO pyridaben results in increased expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163 		JBrowse link
G Zfp580 zinc finger protein 580 decreases expression ISO pyridaben results in decreased expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr 1:68,787,118...68,789,286
Ensembl chr 1:68,787,118...68,789,286 		JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 increases expression ISO pyridaben results in increased expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr 3:149,417,787...149,548,671
Ensembl chr 3:149,417,818...149,527,079 		JBrowse link
pyridaphenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyridafenthion binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Pyridate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding ISO pyridate binds to AR protein CTD PMID:15253041 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding		 ISO pyridate inhibits the reaction [Estradiol binds to ESR1 protein]
pyridate binds to ESR1 protein		 CTD PMID:15253041 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          nitrogen atom 18974
            nitrogen molecular entity 18974
              organonitrogen compound 18827
                organonitrogen heterocyclic compound 18148
                  diazines 13215
                    pyridazines 137
                      (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)\{4-[(6-methoxypyridazin-3-yl)sulfamoyl]anilino\}methanesulfonic acid + 0
                      1,3,8-trimethyl-5,10-diphenylpyrimido[1,2]pyrrolo[4,5-b]pyridazine-2,4-dione 0
                      1-(3,4-dimethylphenyl)-4-(4-methyl-1-piperidinyl)phthalazine 0
                      1-phenyl-1,6-dihydropyridazine 0
                      2-(3-\{(2-chloro-4-fluorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino\}propyl)-1H-isoindole-1,3(2H)-dione 0
                      2-(4-nitrophenoxy)-1-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethanone 0
                      2-Methyl-6-phenyl-2,3-dihydropyridazin-3-one 0
                      2-[(2,6-dichlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                      2-[(3-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                      2-[(4-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                      2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione 0
                      2-[4-[[4-(4-methoxyphenyl)-1-phthalazinyl]amino]phenyl]acetamide 0
                      2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(1-pyrrolidinyl)ethanone 0
                      2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(4-morpholinyl)ethanone 0
                      2-[[6-(4-ethylphenyl)-3-pyridazinyl]thio]-N-(2-oxolanylmethyl)acetamide 0
                      2-hydroxy-1-(4-methylphenyl)-7-phenyl-3-(phenylmethyl)-4-pyrimido[1,2-b]pyridazin-5-iumone 0
                      3(S)-hydroxy-13-cis-eicosenoyl-CoA 0
                      3,5-Dichloropyridazine 0
                      3-Chloro-6-methylpyridazine 0
                      3-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]-N-[2-(2-methyl-1-piperidinyl)ethyl]propanamide 0
                      3-amino-5-(4-bromophenyl)-4-pyridazinecarbonitrile 0
                      3-chloro-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 0
                      3-methoxy-6-[4-(3-methylphenyl)piperazin-1-yl]pyridazine 0
                      3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine 0
                      3-oxido-4,5-dihydro-[1,2,5]oxadiazolo[3,4-f]cinnolin-3-ium 0
                      3-phenyl-1H-cinnolin-4-one 0
                      4,5-diphenyl-2,3-dihydro-1H-pyrazolo[3,4-c]pyridazin-3-one 0
                      4-(2,4-dimethylphenyl)-2H-phthalazin-1-one 0
                      4-(3-bromophenyl)-2-(4-bromophenyl)-7-methylpyrazolo[3,4-d]pyridazine 0
                      4-(3-bromophenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine 0
                      4-(4-hydroxy-3,5-dimethylphenyl)-2-methylphthalazin-1(2H)-one 0
                      4-(cyclohexylmethyl)-6-(2-thienyl)-2,3-dihydropyridazin-3-one hydrate 0
                      4-[6-amino-3-(4-methoxyphenyl)-1-pyridazin-1-iumyl]butanoic acid 0
                      5-Chloropyridazin-3(2H)-one 0
                      5-Methyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                      6-(2-Thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                      6-(4-ethylphenyl)-3-(methylthio)-[1,2,4]triazolo[4,3-b]pyridazine 0
                      6-Methyl-2,3,4,5-tetrahydropyridazin-3-one 0
                      6-Methylpyridazin-3(2H)-one 0
                      6-Phenyl-2,3,4,5-tetrahydropyridazin-3-one 0
                      6-[(5-chloro-3-methyl-1-benzofuran-2-yl)sulfonyl]pyridazin-3(2H)-one 0
                      6-phenyl-5-(1-piperidinyl)-2-prop-2-enyl-3-pyridazinone 0
                      Cintazone 0
                      Ethyl 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxylate 0
                      Gandotinib 0
                      N,N-dimethyl-6-phenyl-3-pyridazinamine 0
                      N-(3,4-dichlorophenyl)-2-[4-(4-methoxyphenyl)-1-oxo-2-phthalazinyl]acetamide 0
                      N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine 0
                      N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 0
                      N-(5-methyl-3-isoxazolyl)-2-[[6-(4-methylphenyl)-3-pyridazinyl]thio]acetamide 0
                      N-[2-(4-morpholinyl)ethyl]-6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-amine 0
                      N-[2-(dimethylamino)ethyl]-2-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]acetamide 0
                      N-[2-methoxy-5-(3-methyl-4-oxo-1-phthalazinyl)phenyl]-2-(4-methylphenoxy)acetamide 0
                      N-[3-[6-(1-azepanyl)-3-pyridazinyl]phenyl]-4-methylbenzenesulfonamide 0
                      N-[4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]cyclohexanecarboxamide 0
                      N-cyclohexyl-2-[[6-(4-ethoxyphenyl)-3-pyridazinyl]thio]acetamide 0
                      N-methyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 0
                      Pyridate 2
                      azafagomine 0
                      chloridazone-desphenyl 0
                      cyclopyrimorate 0
                      irdabisant 0
                      minaprine + 0
                      omipalisib 16
                      pyridazine 0
                      pyridazinone + 122
                      pyridazinylpiperidine + 0
                      sulfachloropyridazine 0
                      sulfamethoxypyridazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteromonocyclic compound 17791
                                    diazines 13215
                                      pyridazines 137
                                        (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)\{4-[(6-methoxypyridazin-3-yl)sulfamoyl]anilino\}methanesulfonic acid + 0
                                        1,3,8-trimethyl-5,10-diphenylpyrimido[1,2]pyrrolo[4,5-b]pyridazine-2,4-dione 0
                                        1-(3,4-dimethylphenyl)-4-(4-methyl-1-piperidinyl)phthalazine 0
                                        1-phenyl-1,6-dihydropyridazine 0
                                        2-(3-\{(2-chloro-4-fluorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino\}propyl)-1H-isoindole-1,3(2H)-dione 0
                                        2-(4-nitrophenoxy)-1-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethanone 0
                                        2-Methyl-6-phenyl-2,3-dihydropyridazin-3-one 0
                                        2-[(2,6-dichlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                                        2-[(3-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                                        2-[(4-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone 0
                                        2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione 0
                                        2-[4-[[4-(4-methoxyphenyl)-1-phthalazinyl]amino]phenyl]acetamide 0
                                        2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(1-pyrrolidinyl)ethanone 0
                                        2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(4-morpholinyl)ethanone 0
                                        2-[[6-(4-ethylphenyl)-3-pyridazinyl]thio]-N-(2-oxolanylmethyl)acetamide 0
                                        2-hydroxy-1-(4-methylphenyl)-7-phenyl-3-(phenylmethyl)-4-pyrimido[1,2-b]pyridazin-5-iumone 0
                                        3(S)-hydroxy-13-cis-eicosenoyl-CoA 0
                                        3,5-Dichloropyridazine 0
                                        3-Chloro-6-methylpyridazine 0
                                        3-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]-N-[2-(2-methyl-1-piperidinyl)ethyl]propanamide 0
                                        3-amino-5-(4-bromophenyl)-4-pyridazinecarbonitrile 0
                                        3-chloro-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 0
                                        3-methoxy-6-[4-(3-methylphenyl)piperazin-1-yl]pyridazine 0
                                        3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine 0
                                        3-oxido-4,5-dihydro-[1,2,5]oxadiazolo[3,4-f]cinnolin-3-ium 0
                                        3-phenyl-1H-cinnolin-4-one 0
                                        4,5-diphenyl-2,3-dihydro-1H-pyrazolo[3,4-c]pyridazin-3-one 0
                                        4-(2,4-dimethylphenyl)-2H-phthalazin-1-one 0
                                        4-(3-bromophenyl)-2-(4-bromophenyl)-7-methylpyrazolo[3,4-d]pyridazine 0
                                        4-(3-bromophenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine 0
                                        4-(4-hydroxy-3,5-dimethylphenyl)-2-methylphthalazin-1(2H)-one 0
                                        4-(cyclohexylmethyl)-6-(2-thienyl)-2,3-dihydropyridazin-3-one hydrate 0
                                        4-[6-amino-3-(4-methoxyphenyl)-1-pyridazin-1-iumyl]butanoic acid 0
                                        5-Chloropyridazin-3(2H)-one 0
                                        5-Methyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                                        6-(2-Thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                                        6-(4-ethylphenyl)-3-(methylthio)-[1,2,4]triazolo[4,3-b]pyridazine 0
                                        6-Methyl-2,3,4,5-tetrahydropyridazin-3-one 0
                                        6-Methylpyridazin-3(2H)-one 0
                                        6-Phenyl-2,3,4,5-tetrahydropyridazin-3-one 0
                                        6-[(5-chloro-3-methyl-1-benzofuran-2-yl)sulfonyl]pyridazin-3(2H)-one 0
                                        6-phenyl-5-(1-piperidinyl)-2-prop-2-enyl-3-pyridazinone 0
                                        Cintazone 0
                                        Ethyl 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxylate 0
                                        Gandotinib 0
                                        N,N-dimethyl-6-phenyl-3-pyridazinamine 0
                                        N-(3,4-dichlorophenyl)-2-[4-(4-methoxyphenyl)-1-oxo-2-phthalazinyl]acetamide 0
                                        N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine 0
                                        N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 0
                                        N-(5-methyl-3-isoxazolyl)-2-[[6-(4-methylphenyl)-3-pyridazinyl]thio]acetamide 0
                                        N-[2-(4-morpholinyl)ethyl]-6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-amine 0
                                        N-[2-(dimethylamino)ethyl]-2-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]acetamide 0
                                        N-[2-methoxy-5-(3-methyl-4-oxo-1-phthalazinyl)phenyl]-2-(4-methylphenoxy)acetamide 0
                                        N-[3-[6-(1-azepanyl)-3-pyridazinyl]phenyl]-4-methylbenzenesulfonamide 0
                                        N-[4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]cyclohexanecarboxamide 0
                                        N-cyclohexyl-2-[[6-(4-ethoxyphenyl)-3-pyridazinyl]thio]acetamide 0
                                        N-methyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 0
                                        Pyridate 2
                                        azafagomine 0
                                        chloridazone-desphenyl 0
                                        cyclopyrimorate 0
                                        irdabisant 0
                                        minaprine + 0
                                        omipalisib 16
                                        pyridazine 0
                                        pyridazinone + 122
                                        pyridazinylpiperidine + 0
                                        sulfachloropyridazine 0
                                        sulfamethoxypyridazine 0
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