clozapine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	clozapine	go back to main search page
Accession:	CHEBI:3766	browse the term
Definition:	A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Synonyms:	exact_synonym:	8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
	related_synonym:	Clozapin; Formula=C18H19ClN4; InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3; InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N; SMILES=N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C; clozapina; clozapinum
	xref:	Beilstein:0764984; CAS:5786-21-0; DrugBank:DB00363; Drug_Central:722; HMDB:HMDB0014507; KEGG:C06924; KEGG:D00283
	xref_mesh:	MESH:D003024
	xref:	PMID:18690109; PMID:18766167; PMID:20825390; PMID:24219174; Patent:FR1334944; Patent:NL293201; Patent:US3539573; Reaxys:764984; Wikipedia:Clozapine

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Genes (750)

clozapine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of AARS1 protein

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases activity

Clozapine results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein

PMID:9111066 PMID:16810505

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily E member 1

increases expression

Clozapine results in increased expression of ABCE1 protein

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily G member 1

increases expression

Clozapine results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions

Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

actin binding LIM protein family, member 2

increases expression

Clozapine results in increased expression of ABLIM2 mRNA

NCBI chr14:74,865,409...74,990,334
Ensembl chr14:74,866,281...74,990,334

G

acetyl-CoA acetyltransferase 2

increases expression

Clozapine results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA thioesterase 2

increases expression

Clozapine results in increased expression of ACOT2 protein

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 7

decreases expression

Clozapine results in decreased expression of ACOT7 protein

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA oxidase 1

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

actin, beta

decreases expression

Clozapine results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, beta-like 2

increases expression

Clozapine results in increased expression of ACTBL2 protein

NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767

G

actin related protein 3

decreases expression

Clozapine results in decreased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

actin related protein 5

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein

NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110

G

ADAM metallopeptidase domain 1a

decreases expression

Clozapine results in decreased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

adenylate cyclase 5

affects response to substance
multiple interactions

ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions
increases expression

Clozapine results in decreased expression of ADIPOQ protein
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]
Clozapine results in increased expression of ADIPOQ protein

PMID:17933447 PMID:18162013 PMID:20564506

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A2a receptor

decreases expression

Clozapine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1A

multiple interactions

Clozapine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

Clozapine results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

G

angiotensinogen

multiple interactions

Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

Clozapine results in increased expression of AIMP1 protein

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 1

decreases expression

Clozapine results in decreased expression of AK1 protein

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

AKT serine/threonine kinase 1

increases expression
increases phosphorylation
decreases expression

Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in increased phosphorylation of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA

PMID:15860345 PMID:19440698

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases expression

Clozapine results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

multiple interactions
affects binding

Clozapine results in decreased expression of and results in decreased reduction of ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Clozapine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Clozapine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

increases expression
decreases expression

Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein

PMID:34122009 PMID:36482696

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA

PMID:15860345 PMID:16465460

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkaline phosphatase, placental

multiple interactions

Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

Aly/REF export factor

decreases expression

Clozapine results in decreased expression of ALYREF protein

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

G

annexin A1

decreases expression

Clozapine results in decreased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

decreases expression

Clozapine results in decreased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Clozapine results in decreased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Clozapine results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 2 subunit beta 1

increases expression

Clozapine results in increased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

adaptor related protein complex 3 subunit beta 1

increases expression

Clozapine results in increased expression of AP3B1 protein

NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935

G

apolipoprotein A5

affects response to substance

APOA5 gene polymorphism affects the susceptibility to Clozapine

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein D

increases expression

Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein

PMID:11158250 PMID:14647396 PMID:17266109

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

increases expression

Clozapine results in increased expression of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

decreases expression

Clozapine results in decreased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

Cdc42 guanine nucleotide exchange factor 9

decreases expression

Clozapine results in decreased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

G

ADP-ribosylation factor like GTPase 8A

decreases expression

Clozapine results in decreased expression of ARL8A protein

NCBI chr13:46,585,845...46,594,851
Ensembl chr13:46,585,845...46,594,851

G

acidic residue methyltransferase 1

increases expression

Clozapine results in increased expression of ARMT1 protein

NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302

G

actin related protein 2/3 complex, subunit 4

affects expression

Clozapine affects the expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

N-acylsphingosine amidohydrolase 1

increases expression

Clozapine results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein

PMID:15342952 PMID:17175557 PMID:36482696

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Clozapine results in increased expression of ASPH protein

NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876

G

argininosuccinate synthase 1

increases expression

Clozapine results in increased expression of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 3A

decreases expression

Clozapine results in decreased expression of ATAD3A protein

NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Clozapine results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit beta

decreases expression

Clozapine results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Clozapine results in increased expression of ATP5PB protein

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATPase H+ transporting V1 subunit A

decreases expression

Clozapine results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B1

decreases expression

Clozapine results in decreased expression of ATP6V1B1 protein

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

ATPase H+ transporting V1 subunit B2

decreases expression

Clozapine results in decreased expression of ATP6V1B2 protein

PMID:19441803 PMID:34122009

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ataxin 10

increases expression

Clozapine results in increased expression of ATXN10 protein

NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087

G

axin 2

decreases expression

Clozapine results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

beta-secretase 2

increases expression

Clozapine results in increased expression of BACE2 protein

NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression
multiple interactions

Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
Clozapine results in decreased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]

PMID:16160616 PMID:17069804

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCAR1 scaffold protein, Cas family member

decreases expression

Clozapine results in decreased expression of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

increases expression

Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 14

decreases expression

Clozapine results in decreased expression of BCL2L14 protein

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

brain-derived neurotrophic factor

decreases expression
increases expression

Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein

PMID:11488957 PMID:12478621 PMID:17442489

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

Bet1 golgi vesicular membrane trafficking protein-like

decreases expression

Clozapine results in decreased expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

BCL2-interacting killer

multiple interactions
increases expression

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

bromodomain PHD finger transcription factor

decreases expression

Clozapine results in decreased expression of BPTF mRNA

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

basic leucine zipper and W2 domains 1

increases expression

Clozapine results in increased expression of BZW1 protein

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

Clozapine results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium binding and coiled coil domain 1

increases expression

Clozapine results in increased expression of CALCOCO1 protein

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calmodulin 2

increases expression

Clozapine results in increased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calreticulin

decreases expression

Clozapine results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

decreases expression

Clozapine results in decreased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression
increases expression

Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein

PMID:15860345 PMID:17266109 PMID:19289156

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Clozapine results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Clozapine results in decreased expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase IV

increases expression
decreases expression

Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein

PMID:15860345 PMID:19289156

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

Clozapine results in decreased expression of CAMKK1 protein

NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

Clozapine results in decreased expression of CAMKK2 protein

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

calnexin

decreases expression

Clozapine results in decreased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

cysteinyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of CARS1 protein

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

CART prepropeptide

decreases expression

Clozapine results in decreased expression of CARTPT mRNA

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

caspase 1

increases activity

Clozapine results in increased activity of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions

Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]

PMID:22700542 PMID:24709159

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

increases expression

Clozapine results in increased expression of CCAR1 protein

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 47

increases expression
multiple interactions

Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein

NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881

G

cholecystokinin

multiple interactions
increases expression

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA

PMID:10974607 PMID:16567023

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

increases expression

Clozapine results in increased expression of CCKBR mRNA

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 1

decreases expression

Clozapine results in decreased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

cyclin D1

decreases expression

Clozapine results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

increases expression

Clozapine results in increased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin L1

increases expression

Clozapine results in increased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

chaperonin containing TCP1 subunit 7

decreases expression

Clozapine results in decreased expression of CCT7 protein

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

Cd276 molecule

decreases expression

Clozapine results in decreased expression of CD276 protein

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

Cd63 molecule

increases expression

Clozapine results in increased expression of CD63 protein

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

increases expression

Clozapine results in increased expression of CDIPT protein

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

G

cyclin-dependent kinase 4

increases expression

Clozapine results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

increases expression

Clozapine results in increased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Clozapine results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein V

increases expression

Clozapine results in increased expression of CENPV protein

NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761

G

cilia and flagella associated protein 210

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein

NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607

G

coiled-coil-helix-coiled-coil-helix domain containing 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein

NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755

G

chromodomain helicase DNA binding protein 4

decreases expression

Clozapine results in decreased expression of CHD4 protein

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

chromogranin A

decreases expression
increases expression

Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

cell adhesion molecule L1-like

decreases expression

Clozapine results in decreased expression of CHL1 mRNA

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

G

chimerin 1

decreases expression

Clozapine results in decreased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cysteine and histidine rich domain containing 1

increases expression

Clozapine results in increased expression of CHORDC1 protein

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cholinergic receptor, muscarinic 1

affects binding
multiple interactions
increases expression

Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]
Clozapine results in increased expression of CHRM1 protein

PMID:11997696 PMID:16983399 PMID:18806925

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cytoskeleton-associated protein 4

increases expression

Clozapine results in increased expression of CKAP4 protein

NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914

G

chloride intracellular channel 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

chloride intracellular channel 4

increases expression

Clozapine results in increased expression of CLIC4 protein

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

clock circadian regulator

affects response to substance

CLOCK gene SNP affects the susceptibility to Clozapine

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

clathrin, light chain A

decreases expression

Clozapine results in decreased expression of CLTA mRNA

NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472

G

clathrin, light chain B

decreases expression

Clozapine results in decreased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression
increases expression

Clozapine results in decreased expression of CNP mRNA
Clozapine results in increased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein

PMID:17266109 PMID:34122009

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

coilin

increases expression

Clozapine results in increased expression of COIL mRNA

NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393

G

collagen type V alpha 2 chain

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

catechol-O-methyltransferase

multiple interactions
increases response to substance
affects response to substance

[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT gene polymorphism results in increased susceptibility to Clozapine
COMT protein affects the susceptibility to Clozapine

PMID:15190105 PMID:17123785

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COP9 signalosome subunit 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein

NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597

G

coronin 1B

decreases expression

Clozapine results in decreased expression of CORO1B protein

NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416

G

complexin 2

decreases expression

Clozapine results in decreased expression of CPLX2 mRNA

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

carboxypeptidase N subunit 1

increases expression

Clozapine results in increased expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

copine 1

decreases expression

Clozapine results in decreased expression of CPNE1 protein

NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636

G

carnitine palmitoyltransferase 2

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

decreases expression

Clozapine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone binding protein

decreases expression

Clozapine results in decreased expression of CRHBP mRNA

NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710

G

C-reactive protein

increases expression

Clozapine results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 3

multiple interactions

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 2 alpha 1

decreases expression

Clozapine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

cystatin C

increases expression

Clozapine results in increased expression of CST3 mRNA

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

cleavage stimulation factor subunit 1

decreases expression

Clozapine results in decreased expression of CSTF1 protein

NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300

G

cleavage stimulation factor subunit 2

decreases expression

Clozapine results in decreased expression of CSTF2 protein

NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476

G

C-terminal binding protein 1

increases expression

Clozapine results in increased expression of CTBP1 protein

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

catenin beta 1

increases expression
multiple interactions

Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsin-like

increases expression

Clozapine results in increased expression of CTRL mRNA

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin K

increases expression

Clozapine results in increased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cortactin

increases expression

Clozapine results in increased expression of CTTN protein

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cullin 2

increases expression

Clozapine results in increased expression of CUL2 protein

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 3

increases expression

Clozapine results in increased expression of CUL3 protein

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

C-X-C motif chemokine ligand 1

decreases expression
increases secretion
multiple interactions
decreases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in increased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:34935985 PMID:36482696

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases secretion

Clozapine results in decreased secretion of CXCL10 protein

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

decreases expression
decreases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:36482696

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

similar to human chromosome X open reading frame 49

increases expression

Clozapine results in increased expression of CXORF49 protein

NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293

G

cytochrome b5 type B

increases expression

Clozapine results in increased expression of CYB5B mRNA

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b5 reductase 1

increases expression

Clozapine results in increased expression of CYB5R1 protein

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases metabolic processing
decreases activity

Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CYP1A1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1A1 protein

PMID:18493746 PMID:18809730 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance
decreases metabolic processing
increases metabolic processing
affects response to substance
multiple interactions
affects metabolic processing
increases expression

CYP1A2 gene SNP results in decreased susceptibility to Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA

PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
decreases activity

CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein

PMID:18809730 PMID:33814510

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases metabolic processing

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

CYP2C8 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
multiple interactions
increases metabolic processing

CYP2D6 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2D6 protein results in increased metabolism of Clozapine

PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases metabolic processing

CYP2J2 protein results in increased metabolism of Clozapine

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
multiple interactions
affects metabolic processing

CYP3A4 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]
CYP3A4 protein affects the metabolism of Clozapine

PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

CYP3A5 protein results in increased metabolism of Clozapine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

DAB adaptor protein 1

increases expression

Clozapine results in increased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

DAB adaptor protein 2

increases expression

Clozapine results in increased expression of DAB2 protein

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

diacylglycerol lipase, beta

increases expression

Clozapine results in increased expression of DAGLB protein

NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154

G

DDB1 and CUL4 associated factor 6

decreases expression

Clozapine results in decreased expression of DCAF6 mRNA

NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512

G

doublecortin-like kinase 1

increases expression

Clozapine results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

dopa decarboxylase

multiple interactions
increases expression

Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DEAD-box helicase 46

increases expression

Clozapine results in increased expression of DDX46 protein

NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439

G

DENN domain containing 10

increases expression

Clozapine results in increased expression of DENND10 mRNA

NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455

G

DEPP autophagy regulator 1

increases expression

Clozapine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

DiGeorge syndrome critical region gene 6

decreases expression

Clozapine results in decreased expression of DGCR6 protein

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

diacylglycerol kinase, alpha

decreases expression

Clozapine results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

24-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR24 protein

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DExH-box helicase 30

increases expression

Clozapine results in increased expression of DHX30 protein

NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381

G

DEAH-box helicase 38

decreases expression

Clozapine results in decreased expression of DHX38 protein

NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140

G

DISC1 scaffold protein

decreases response to substance
affects response to substance

DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine

NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778

G

dihydrolipoamide S-acetyltransferase

decreases expression
increases expression

Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein

PMID:15860345 PMID:34122009

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Clozapine results in increased expression of DLG2 protein

NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475

G

dihydrolipoamide S-succinyltransferase

decreases expression

Clozapine results in decreased expression of DLST protein

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

dynein, axonemal, heavy chain 11

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

Clozapine results in increased expression of DNAJB11 protein

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

double PHD fingers 1

affects expression

Clozapine affects the expression of DPF1 mRNA

NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950

G

dipeptidylpeptidase 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein

NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541

G

dihydropyrimidinase-like 3

decreases expression

Clozapine results in decreased expression of DPYSL3 protein

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

dihydropyrimidinase-like 4

decreases expression

Clozapine results in decreased expression of DPYSL4 protein

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

down-regulator of transcription 1

decreases expression

Clozapine results in decreased expression of DR1 protein

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D1

affects binding
affects response to substance
decreases expression

Clozapine binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine
Clozapine analog binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA

PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
affects response to substance
increases response to substance
affects binding
decreases expression

[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine
DRD2 gene SNP results in increased susceptibility to Clozapine
Clozapine binds to DRD2 protein alternative form
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine results in decreased expression of DRD2 mRNA
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

affects response to substance
decreases response to substance
multiple interactions

DRD3 protein affects the susceptibility to Clozapine
DRD3 gene polymorphism results in decreased susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]

PMID:15579174 PMID:20029384

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects binding
affects response to substance
multiple interactions

Clozapine binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine
Clozapine analog binds to DRD4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine binds to Drd4 protein

CTD
RGD

PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

dystrophin related protein 2

increases expression

Clozapine results in increased expression of DRP2 mRNA alternative form

NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

dual specificity phosphatase 1

decreases expression

Clozapine results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

decreases expression

Clozapine results in decreased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dishevelled segment polarity protein 3

increases expression
multiple interactions

Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

Clozapine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

Clozapine results in decreased expression of DYNC1LI2 protein

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

enhancer of mRNA decapping 4

increases expression

Clozapine results in increased expression of EDC4 protein

NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758

G

eukaryotic translation elongation factor 1 alpha 2

increases expression

Clozapine results in increased expression of EEF1A2 protein

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

eukaryotic translation elongation factor 1 delta

decreases expression

Clozapine results in decreased expression of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

early growth response 1

decreases expression

Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein

PMID:17028028 PMID:18208916

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

affects expression
decreases expression

Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein

PMID:17028028 PMID:19401217

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

affects response to substance

EGR3 protein affects the susceptibility to Clozapine

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

Clozapine results in increased expression of EIF2S3 protein

NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit J

increases expression

Clozapine results in increased expression of EIF3J protein

NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953

G

eukaryotic translation initiation factor 3, subunit M

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 4A3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein

NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057

G

eukaryotic translation initiation factor 4E

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 5B

increases expression

Clozapine results in increased expression of EIF5B protein

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

eukaryotic translation initiation factor 6

decreases expression

Clozapine results in decreased expression of EIF6 protein

NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401

G

ETS transcription factor ELK1

decreases phosphorylation

Clozapine results in decreased phosphorylation of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

enolase 1

increases expression

Clozapine results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

enolase 3

increases expression

Clozapine results in increased expression of ENO3 protein

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

Eph receptor A7

increases expression

Clozapine results in increased expression of EPHA7 mRNA

NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112

G

Eph receptor B3

increases expression

Clozapine results in increased expression of EPHB3 protein

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

endoplasmic reticulum aminopeptidase 1

decreases expression

Clozapine results in decreased expression of ERAP1 protein

NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447

G

erb-b2 receptor tyrosine kinase 2

affects phosphorylation

Clozapine affects the phosphorylation of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERH, mRNA splicing and mitosis factor

increases expression

Clozapine results in increased expression of ERH protein

NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210

G

endoplasmic reticulum protein 44

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

EWS RNA-binding protein 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

G

exosome component 4

increases expression

Clozapine results in increased expression of EXOSC4 protein

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

ezrin

decreases expression

Clozapine results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 1

increases expression

Clozapine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

FANCD2 and FANCI associated nuclease 1

increases expression

Clozapine results in increased expression of FAN1 protein

NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977

G

phenylalanyl-tRNA synthetase subunit alpha

increases expression

Clozapine results in increased expression of FARSA protein

NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980

G

phenylalanyl-tRNA synthetase subunit beta

increases expression

Clozapine results in increased expression of FARSB protein

NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045

G

Fas cell surface death receptor

multiple interactions

[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

increases expression

Clozapine results in increased expression of FASN mRNA

PMID:16027736 PMID:17052361

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

farnesyl diphosphate synthase

increases expression

Clozapine results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

flap structure-specific endonuclease 1

increases expression

Clozapine results in increased expression of FEN1 protein

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

fibroblast growth factor 2

increases expression

Clozapine results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibrinogen-like 1

increases expression

Clozapine results in increased expression of FGL1 protein

NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093

G

formin homology 2 domain containing 1

decreases expression

Clozapine results in decreased expression of FHOD1 protein

NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356

G

FKBP prolyl isomerase 8

decreases expression

Clozapine results in decreased expression of FKBP8 protein

NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612

G

flotillin 2

increases expression

Clozapine results in increased expression of FLOT2 protein

NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of Clozapine

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 3

increases metabolic processing

FMO3 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibronectin type III domain containing 4

increases expression

Clozapine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in decreased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein

PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression
multiple interactions

Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in decreased expression of FOSB mRNA
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein

PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of FOSL2 mRNA

PMID:12093589 PMID:12243769

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box P2

increases expression

Clozapine results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

follistatin-like 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

far upstream element binding protein 1

increases expression

Clozapine results in increased expression of FUBP1 protein

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glucose-6-phosphate dehydrogenase

decreases expression

Clozapine results in decreased expression of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

increases expression

Clozapine results in increased expression of GABARAPL2 protein

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
Ensembl chr 8:39,910,534...39,924,628

G

gamma-aminobutyric acid type B receptor subunit 1

decreases expression

Clozapine results in decreased expression of GABBR1 mRNA

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

Clozapine results in increased expression of GABRA1 mRNA

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases expression

Clozapine results in increased expression of GABRB3 mRNA

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

glutamate decarboxylase 1

increases expression
multiple interactions
decreases methylation

Clozapine results in increased expression of GAD1 mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]

PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

increases expression

Clozapine results in increased expression of GAD2 mRNA

PMID:17266109 PMID:18923069

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein

PMID:15860345 PMID:34122009

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

increases expression

Clozapine results in increased expression of GART protein

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

glycine amidinotransferase

increases expression

Clozapine results in increased expression of GATM protein

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

GRIP and coiled-coil domain containing 2

decreases expression

Clozapine results in decreased expression of GCC2 protein

NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613

G

growth differentiation factor 15

increases expression

Clozapine results in increased expression of GDF15 protein

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Clozapine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

glial fibrillary acidic protein

decreases expression
increases expression

Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA

PMID:18585900 PMID:19441803

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth hormone inducible transmembrane protein

increases expression

Clozapine results in increased expression of GHITM protein

NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879

G

GTPase, IMAP family member 5

decreases expression

Clozapine results in decreased expression of GIMAP5 mRNA

NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086

G

gastric inhibitory polypeptide

increases expression

Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

gap junction protein, alpha 1

increases expression

Clozapine results in increased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glucagon-like peptide 1 receptor

multiple interactions
decreases expression

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

glutaredoxin 3

increases expression

Clozapine results in increased expression of GLRX3 protein

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

G

glutamate-ammonia ligase

decreases expression

Clozapine results in decreased expression of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein subunit alpha 12

decreases expression
increases expression

Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein

PMID:15860345 PMID:34122009

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

G protein subunit alpha i1

decreases expression

Clozapine results in decreased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

decreases expression

Clozapine results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha i3

decreases expression

Clozapine results in decreased expression of GNAI3 mRNA

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

GNAS complex locus

decreases expression
increases expression
multiple interactions

Clozapine results in decreased expression of GNAS mRNA
Clozapine results in increased expression of GNAS protein
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein

PMID:15860345 PMID:34122009

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit beta 3

decreases response to substance
increases response to substance
affects response to substance
increases expression

GNB3 gene polymorphism results in decreased susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine
GNB3 protein affects the susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein

PMID:16139171 PMID:16141801 PMID:18855531

NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173

G

golgin A3

increases expression

Clozapine results in increased expression of GOLGA3 protein

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509

G

golgin B1

increases expression

Clozapine results in increased expression of GOLGB1 protein

NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770

G

glutamic-oxaloacetic transaminase 2

increases expression
multiple interactions

Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein

PMID:15860345 PMID:34122009

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycerol-3-phosphate dehydrogenase 2

decreases expression

Clozapine results in decreased expression of GPD2 protein

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glucose-6-phosphate isomerase

increases expression

Clozapine results in increased expression of GPI protein

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutamic--pyruvic transaminase

multiple interactions

[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression

Clozapine results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

Clozapine results in increased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor kainate type subunit 5

affects expression
decreases expression

Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA

PMID:14647396 PMID:18923069

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression
increases expression

Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA

PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Clozapine results in decreased expression of GRIN2A mRNA

PMID:12608697 PMID:18923069

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

Clozapine results in decreased expression of GRIN2B mRNA

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Clozapine results in decreased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

G protein-coupled receptor kinase 6

decreases expression

Clozapine results in decreased expression of GRK6 mRNA

NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644

G

glycogen synthase kinase 3 alpha

increases expression
multiple interactions

Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions
increases expression

Clozapine results in increased phosphorylation of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]

PMID:16144542 PMID:19359144 PMID:19440698

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase alpha 1

decreases activity
increases glutathionylation

GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase mu 1

decreases activity
increases glutathionylation
increases expression

GSTM1 protein results in decreased activity of Clozapine
GSTM1 protein results in increased glutathionylation of Clozapine
Clozapine results in increased expression of GSTM1 mRNA

PMID:15860345 PMID:20849150

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases expression

Clozapine results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

decreases activity
affects binding
increases glutathionylation
affects metabolic processing

Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
Clozapine metabolite binds to GSTP1 protein
GSTP1 protein results in increased glutathionylation of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite

PMID:20849150 PMID:21639118 PMID:24185126

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H1.2 linker histone, cluster member

increases expression

Clozapine results in increased expression of H1-2 protein

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2A clustered histone 18

increases expression

Clozapine results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

G

H2A clustered histone 20

increases expression

Clozapine results in increased expression of H2AC20 protein

NCBI chr 2:183,779,879...183,780,357

G

H2A.J histone

increases expression

Clozapine results in increased expression of H2AJ protein

NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

Clozapine results in decreased expression of HAAO protein

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

Clozapine results in increased expression of HACD3 protein

NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Clozapine results in increased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of HARS1 protein

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

histone acetyltransferase 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hematopoietic cell specific Lyn substrate 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein

NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014

G

HDGF like 2

increases expression

Clozapine results in increased expression of HDGFRP2 protein

NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

Clozapine results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

high mobility group box 2

increases expression

Clozapine results in increased expression of HMGB2 protein

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases activity
increases expression

[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Clozapine results in increased expression of HMGCS1 mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression

Clozapine results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Clozapine results in decreased expression of HNRNPD protein

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

heterogeneous nuclear ribonucleoprotein H2

decreases expression

Clozapine results in decreased expression of HNRNPH2 protein

NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041

G

homer scaffold protein 1

increases expression
multiple interactions

Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]

PMID:12464447 PMID:15860345

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

hippocalcin-like 1

decreases expression

Clozapine results in decreased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

hippocalcin-like 4

affects expression

Clozapine affects the expression of HPCAL4 mRNA

NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416

G

hepsin

increases expression

Clozapine results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

histamine receptor H 1

affects binding

Clozapine binds to HRH1 protein

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H3

multiple interactions

Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]

RGD

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

Clozapine results in decreased expression of HSD17B10 protein

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

Clozapine results in increased expression of HSD17B12 protein

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

heat shock protein family A (Hsp70) member 9

decreases expression

Clozapine results in decreased expression of HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

5-hydroxytryptamine receptor 1A

multiple interactions
affects binding

Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein

PMID:9723970 PMID:15482641

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1D

decreases expression

Clozapine results in decreased expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

G

5-hydroxytryptamine receptor 2A

increases response to substance
increases expression
affects response to substance
multiple interactions
affects binding
decreases activity
decreases expression

HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA
HTR2A protein affects the susceptibility to Clozapine
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
Clozapine binds to HTR2A protein
Clozapine results in decreased activity of HTR2A protein
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein

PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More...

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 2C

affects binding
affects response to substance
decreases expression

Clozapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of HTR2C mRNA

PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More...

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

5-hydroxytryptamine receptor 3A

multiple interactions
affects response to substance

Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine

PMID:19696922 PMID:20168265

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

5-hydroxytryptamine receptor 6

multiple interactions
affects binding

Clozapine binds to and results in decreased activity of HTR6 protein
Clozapine binds to HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein

PMID:11406289 PMID:16983399 PMID:34122009

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

inhibitor of DNA binding 2

increases expression

Clozapine results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Clozapine results in decreased expression of IDI1 protein

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon gamma

affects expression
decreases expression

Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

Clozapine results in increased expression of IFNGR1 protein

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

insulin-like growth factor 1

decreases expression

Clozapine results in decreased expression of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 1

increases expression

Clozapine results in increased expression of IGFBP1 protein

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 10

decreases expression

Clozapine results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

increases secretion
multiple interactions

Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2 receptor subunit alpha

increases secretion

Clozapine results in increased secretion of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 5

affects expression

Clozapine affects the expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

ILK associated serine/threonine phosphatase

decreases expression

Clozapine results in decreased expression of ILKAP mRNA

NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892

G

inhibin subunit alpha

decreases expression

Clozapine results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta E

increases expression

Clozapine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 2

affects secretion
increases expression

Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein

PMID:11769361 PMID:16601995

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

integrin subunit alpha 6

increases expression

Clozapine results in increased expression of ITGA6 protein

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

Janus kinase 1

increases expression

Clozapine results in increased expression of JAK1 protein

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

multiple interactions

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA

PMID:12093589 PMID:15860345 PMID:18208916

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of JUNB mRNA

PMID:12093589 PMID:19695244

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

Clozapine results in decreased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

potassium voltage-gated channel subfamily A member 1

increases expression

Clozapine results in increased expression of KCNA1 mRNA

NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel interacting protein 3

decreases expression
increases expression

Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556

G

potassium two pore domain channel subfamily K member 2

decreases expression

Clozapine results in decreased expression of KCNK2 mRNA

NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435

G

potassium channel tetramerization domain containing 12

decreases expression

Clozapine results in decreased expression of KCTD12 protein

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

G

kinase insert domain receptor

increases expression

Clozapine results in increased expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

Clozapine results in decreased expression of KHDRBS1 protein

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

G

kinesin family member 13B

increases expression

Clozapine results in increased expression of KIF13B protein

NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879

G

kinesin family member 5C

decreases expression

Clozapine results in decreased expression of KIF5C protein

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

kizuna centrosomal protein

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein

NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190

G

kelch domain containing 2

decreases expression

Clozapine results in decreased expression of KLHDC2 protein

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

lysine methyltransferase 2A

increases expression
multiple interactions
decreases expression

Clozapine results in increased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]
Clozapine results in decreased expression of KMT2A mRNA

PMID:14647396 PMID:17942719

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

karyopherin subunit alpha 4

multiple interactions
increases expression

[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

kringle containing transmembrane protein 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein

NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516

G

lactamase, beta 2

increases expression

Clozapine results in increased expression of LACTB2 protein

NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429

G

lysosomal-associated membrane protein 1

increases expression

Clozapine results in increased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

increases expression

Clozapine results in increased expression of LAMTOR3 mRNA

NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607

G

La ribonucleoprotein 7, transcriptional regulator

increases expression

Clozapine results in increased expression of LARP7 protein

NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865

G

lipocalin 1

decreases expression

Clozapine results in decreased expression of LCN1 protein

NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577

G

lactate dehydrogenase B

increases expression

Clozapine results in increased expression of LDHB mRNA

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

low density lipoprotein receptor

increases expression
multiple interactions

Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]

PMID:17052361 PMID:20564506

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

liver enriched antimicrobial peptide 2

increases expression

Clozapine results in increased expression of LEAP2 mRNA

NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244

G

LEM domain nuclear envelope protein 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein

NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626

G

leptin

affects response to substance
increases expression

LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein

PMID:16402076 PMID:17502770

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 8

increases expression

Clozapine results in increased expression of LGALS8 protein

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

lipase A, lysosomal acid type

increases expression

Clozapine results in increased expression of LIPA protein

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

leiomodin 2

increases expression

Clozapine results in increased expression of LMOD2 protein

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lipoprotein lipase

decreases expression
increases expression

Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA

PMID:17266109 PMID:19682446

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 10

increases expression

Clozapine results in increased expression of LRP10 protein

NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505

G

leucine-rich pentatricopeptide repeat containing

increases expression

Clozapine results in increased expression of LRPPRC protein

NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293

G

leucine-rich repeat kinase 2

increases expression

Clozapine results in increased expression of LRRK2 protein

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

lanosterol synthase

increases expression
multiple interactions

Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein

PMID:15342952 PMID:17175557 PMID:34122009

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

leukotriene A4 hydrolase

decreases expression

Clozapine results in decreased expression of LTA4H protein

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

magnesium transporter 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein

NCBI chr X:71,038,489...71,079,704
Ensembl chr X:71,038,489...71,079,699

G

mal, T-cell differentiation protein

decreases expression

Clozapine results in decreased expression of MAL mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

monoamine oxidase B

increases expression

Clozapine results in increased expression of MAOB mRNA

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

microtubule-associated protein 1A

increases expression
decreases expression

Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein

PMID:15860345 PMID:34122009

NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899

G

microtubule-associated protein 1B

decreases expression

Clozapine results in decreased expression of MAP1B protein

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

microtubule-associated protein 1 light chain 3 beta

increases lipidation
multiple interactions

Clozapine results in increased lipidation of MAP1LC3B protein
[Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 1S

increases expression

Clozapine results in increased expression of MAP1S protein

NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988

G

mitogen activated protein kinase kinase 1

decreases expression

Clozapine results in decreased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

increases expression
decreases expression

Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA

PMID:14647396 PMID:15860345

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 5

decreases expression

Clozapine results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase kinase 1

increases expression

Clozapine results in increased expression of MAP3K1 mRNA

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen activated protein kinase kinase kinase 12

increases expression

Clozapine results in increased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
decreases expression

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased phosphorylation of MAPK1 protein
Clozapine results in decreased expression of MAPK1 mRNA

PMID:12871586 PMID:15860345

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects expression

Clozapine affects the expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 6

affects expression

Clozapine affects the expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

mitogen-activated protein kinase 8 interacting protein 1

increases expression

Clozapine results in increased expression of MAPK8IP1 mRNA

NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884

G

mitogen-activated protein kinase 9

affects expression

Clozapine affects the expression of MAPK9 mRNA

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein, RP/EB family, member 1

decreases expression
multiple interactions

Clozapine results in decreased expression of MAPRE1 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein

NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983

G

MAS1 proto-oncogene, G protein-coupled receptor

decreases expression

Clozapine results in decreased expression of MAS1 mRNA

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

methionine adenosyltransferase 2A

decreases expression

Clozapine results in decreased expression of MAT2A protein

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

methionine adenosyltransferase 2 non-catalytic beta subunit

decreases expression

Clozapine results in decreased expression of MAT2B protein

NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777

G

myelin basic protein

increases expression

Clozapine results in increased expression of MBP mRNA

PMID:17266109 PMID:17346280

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

melanocortin 1 receptor

increases expression

Clozapine results in increased expression of MC1R mRNA

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

mediator of DNA damage checkpoint 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

malate dehydrogenase 1

decreases expression

Clozapine results in decreased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

mitofusin 2

decreases expression
multiple interactions

Clozapine results in decreased expression of MFN2 protein
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

mixed lineage kinase domain like pseudokinase

increases expression

Clozapine results in increased expression of MLKL protein

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

matrix metallopeptidase 10

decreases expression

Clozapine results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 14

increases expression

Clozapine results in increased expression of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 7

decreases expression

Clozapine results in decreased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

myelin-associated oligodendrocyte basic protein

increases expression

Clozapine results in increased expression of MOBP mRNA

PMID:15542763 PMID:17266109

NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563

G

myeloperoxidase

affects response to substance
increases oxidation
multiple interactions
increases activity

MPO protein affects the susceptibility to Clozapine
MPO protein results in increased oxidation of Clozapine
Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]
Clozapine results in increased activity of MPO protein

PMID:24588327 PMID:35575633

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MAGUK p55 scaffold protein 3

decreases expression

Clozapine results in decreased expression of MPP3 mRNA

NCBI chr10:86,945,705...86,975,261
Ensembl chr10:86,945,714...86,974,737

G

major histocompatibility complex, class I-related

affects expression

Clozapine affects the expression of MR1 mRNA

NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970

G

metastasis associated 1 family, member 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein

NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946

G

metadherin

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein

NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413

G

methylenetetrahydrofolate reductase

affects response to substance

MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

myeloid-associated differentiation marker

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein

NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035

G

MYB binding protein 1a

increases expression

Clozapine results in increased expression of MYBBP1A protein

NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255

G

myosin heavy chain 10

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein

NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165

G

myosin heavy chain 3

increases expression

Clozapine results in increased expression of MYH3 protein

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

myosin, light chain 1

increases expression

Clozapine results in increased expression of MYL1 protein

NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

decreases expression

Clozapine results in decreased expression of NAA10 protein

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

nucleosome assembly protein 1-like 4

increases expression

Clozapine results in increased expression of NAP1L4 protein

NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020

G

N-acetyltransferase 10

decreases expression

Clozapine results in decreased expression of NAT10 protein

NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927

G

neurocan

decreases expression

Clozapine results in decreased expression of NCAN mRNA

NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436

G

non-SMC condensin I complex, subunit G

increases expression

Clozapine results in increased expression of NCAPG protein

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin I complex, subunit H

decreases expression

Clozapine results in decreased expression of NCAPH protein

PMID:34122009 PMID:36482696

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nuclear cap binding protein subunit 1

decreases expression

Clozapine results in decreased expression of NCBP1 protein

NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089

G

nucleolin

increases expression

Clozapine results in increased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

nuclear receptor coactivator 4

increases expression

Clozapine results in increased expression of NCOA4 protein

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

Clozapine results in increased expression of NDUFV2 mRNA

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

nectin cell adhesion molecule 2

decreases expression

Clozapine results in decreased expression of NECTIN2 protein

NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

Clozapine results in decreased expression of NEDD4 mRNA

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

nestin

decreases expression

Clozapine results in decreased expression of NES protein

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

NFE2 like bZIP transcription factor 2

affects response to substance

NFE2L2 protein affects the susceptibility to Clozapine

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

Clozapine results in decreased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor receptor

decreases expression

Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA

PMID:12111809 PMID:14598305 PMID:16513140

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nucleolar protein interacting with the FHA domain of MKI67

decreases expression

Clozapine results in decreased expression of NIFK protein

NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896

G

nicotinamide N-methyltransferase

increases expression

Clozapine results in increased expression of NNMT protein

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

nicotinamide nucleotide transhydrogenase

decreases expression

Clozapine results in decreased expression of NNT protein

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

Clozapine results in increased expression of NOC2L protein

NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949

G

Nodal modulator 1

increases expression

Clozapine results in increased expression of NOMO3 protein

NCBI chr 1:96,505,460...96,556,280
Ensembl chr 1:96,505,484...96,556,279

G

NOP53 ribosome biogenesis factor

affects expression

Clozapine affects the expression of NOP53 mRNA

NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902

G

notch receptor 2

increases expression

Clozapine results in increased expression of NOTCH2 protein

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

NPL4 homolog, ubiquitin recognition factor

decreases expression

Clozapine results in decreased expression of NPLOC4 protein

NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913

G

neuroplastin

increases expression

Clozapine results in increased expression of NPTN mRNA

NCBI chr 8:58,996,873...59,063,402
Ensembl chr 8:58,996,887...59,063,401

G

neuronal pentraxin 2

decreases expression

Clozapine results in decreased expression of NPTX2 mRNA

NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345

G

neuropeptide Y

decreases expression

Clozapine results in decreased expression of NPY mRNA

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects response to substance
multiple interactions
increases reduction

NQO2 gene SNP affects the susceptibility to Clozapine
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]
NQO2 protein results in increased reduction of Clozapine metabolite

PMID:14617031 PMID:29281794

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Clozapine results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression
decreases expression

Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA

PMID:10987852 PMID:11564422 PMID:19695244

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

increases expression

Clozapine results in increased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

neuregulin 1

increases expression
affects response to substance
affects expression

Clozapine results in increased expression of NRG1 mRNA
NRG1 protein affects the susceptibility to Clozapine
Clozapine affects the expression of NRG1 protein

PMID:15706234 PMID:18184445 PMID:19502011

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

Clozapine results in decreased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

netrin G2

increases expression

Clozapine results in increased expression of NTNG2 mRNA

NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890

G

neurotensin

increases expression

Clozapine results in increased expression of NTS mRNA

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nuclear mitotic apparatus protein 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

NUMB-like, endocytic adaptor protein

decreases expression

Clozapine results in decreased expression of NUMBL mRNA

NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776

G

nucleoporin 160

increases expression

Clozapine results in increased expression of NUP160 protein

NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565

G

nucleoporin 50

increases expression

Clozapine results in increased expression of NUP50 protein

NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905

G

nucleoporin 54

decreases expression

Clozapine results in decreased expression of NUP54 protein

NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028

G

nuclear protein 1, transcriptional regulator

increases expression

Clozapine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

oxysterol binding protein-like 8

increases expression

Clozapine results in increased expression of OSBPL8 mRNA

NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888

G

oxytocin/neurophysin I prepropeptide

affects response to substance

OXT protein affects the susceptibility to Clozapine

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

paralemmin A kinase anchor protein

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein

NCBI chr 5:72,536,986...72,648,524
NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524

G

pantothenate kinase 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein

NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955

G

Parkinsonism associated deglycase

increases expression

Clozapine results in increased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly(rC) binding protein 1

increases expression

Clozapine results in increased expression of PCBP1 protein

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

decreases expression

Clozapine results in decreased expression of PCK2 protein

NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283

G

piccolo (presynaptic cytomatrix protein)

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein

NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885

G

pericentriolar material 1

decreases expression

Clozapine results in decreased expression of PCM1 mRNA

NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091

G

PEST proteolytic signal containing nuclear protein

increases expression

Clozapine results in increased expression of PCNP protein

NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348

G

proprotein convertase subtilisin/kexin type 1 inhibitor

affects expression

Clozapine affects the expression of PCSK1N mRNA

NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566

G

programmed cell death 11

increases expression

Clozapine results in increased expression of PDCD11 protein

NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999

G

phosphodiesterase 10A

increases expression

Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein

PMID:17266109 PMID:18222493

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

phosphodiesterase 1B

increases expression

Clozapine results in increased expression of PDE1B mRNA

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

G

phosphodiesterase 4A

decreases expression

Clozapine results in decreased expression of PDE4A protein

NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961

G

phosphodiesterase 4B

decreases expression
increases expression

Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein

PMID:18222493 PMID:20222156

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

protein disulfide isomerase family A, member 3

decreases expression

Clozapine results in decreased expression of PDIA3 protein

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 4

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

PDZ and LIM domain 5

decreases expression

Clozapine results in decreased expression of PDLIM5 protein

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

phosphatidylethanolamine binding protein 1

decreases expression

Clozapine results in decreased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

proenkephalin

decreases expression
increases expression

Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA

PMID:1635659 PMID:12887421

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

prefoldin subunit 5

increases expression

Clozapine results in increased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

phosphofructokinase, platelet

increases expression

Clozapine results in increased expression of PFKP mRNA

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

decreases expression

Clozapine results in decreased expression of PGAM5 protein

NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420

G

phosphoglycerate kinase 1

increases expression

Clozapine results in increased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

progesterone receptor membrane component 1

multiple interactions

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

phosphatase and actin regulator 1

increases expression

Clozapine results in increased expression of PHACTR1 mRNA

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

G

PHD finger protein 14

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein

NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

Clozapine results in decreased expression of PIK3R3 mRNA

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

phosphatidylinositol transfer protein, beta

increases expression

Clozapine results in increased expression of PITPNB protein

NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314

G

cAMP-dependent protein kinase inhibitor beta

decreases expression

Clozapine results in decreased expression of PKIB mRNA

NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187

G

pyruvate kinase M1/2

increases expression

Clozapine results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase C beta 1

increases expression

Clozapine results in increased expression of PLCB1 mRNA

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

proteolipid protein 1

decreases expression
increases expression

Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA

PMID:17266109 PMID:18797397

NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032

G

plastin 3

decreases expression

Clozapine results in decreased expression of PLS3 protein

NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891

G

PNMA family member 1

increases expression

Clozapine results in increased expression of PNMA1 protein

NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567

G

paraoxonase 3

increases expression

Clozapine results in increased expression of PON3 protein

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

inorganic pyrophosphatase 1

increases expression

Clozapine results in increased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

decreases expression

Clozapine results in decreased expression of PPM1A mRNA

NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

Clozapine results in decreased expression of PPM1B mRNA

NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974

G

protein phosphatase 1 catalytic subunit beta

decreases expression

Clozapine results in decreased expression of PPP1CB mRNA

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 1 catalytic subunit gamma

decreases expression

Clozapine results in decreased expression of PPP1CC mRNA

NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

decreases expression

Clozapine results in decreased expression of PPP1R14B protein

NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

decreases expression

Clozapine results in decreased expression of PPP1R1A mRNA

NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions
increases phosphorylation

Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein

PMID:11880652 PMID:12871586

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

decreases expression

Clozapine results in decreased expression of PPP1R2 mRNA

NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463

G

protein phosphatase 1, regulatory subunit 9B

increases expression

Clozapine results in increased expression of PPP1R9B protein

NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

Clozapine results in decreased expression of PPP2CA mRNA

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Clozapine results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

Clozapine results in increased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 2, regulatory subunit B, alpha

decreases expression

Clozapine results in decreased expression of PPP2R2A mRNA

NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions
decreases expression
increases expression

[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA

PMID:12437575 PMID:16033416

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein phosphatase 4, regulatory subunit 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

protein phosphatase 5, catalytic subunit

affects expression

Clozapine affects the expression of PPP5C mRNA

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

G

peroxiredoxin 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

protein kinase cAMP-activated catalytic subunit alpha

increases expression

Clozapine results in increased expression of PRKACA mRNA

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase cAMP-activated catalytic subunit beta

decreases expression
increases expression

Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA

PMID:11907174 PMID:15860345

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions
decreases expression

Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein

PMID:11907174 PMID:34122009

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

protein kinase cAMP-dependent type II regulatory subunit beta

decreases expression
multiple interactions

Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]

PMID:11907174 PMID:15860345

NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933

G

protein kinase C, beta

affects expression
increases expression

Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA

PMID:15860345 PMID:15967061

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, epsilon

increases expression

Clozapine results in increased expression of PRKCE mRNA

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein kinase C, zeta

increases expression

Clozapine results in increased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

prolactin

increases secretion
multiple interactions
increases expression

Clozapine results in increased secretion of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein
Clozapine analog results in increased expression of PRL protein

PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

protein arginine methyltransferase 1

decreases expression

Clozapine results in decreased expression of PRMT1 protein

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

protein C, inactivator of coagulation factors Va and VIIIa

increases expression

Clozapine results in increased expression of PROC protein

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

pre-mRNA processing factor 38B

decreases expression

Clozapine results in decreased expression of PRPF38B mRNA

NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250

G

pre-mRNA processing factor 6

decreases expression
multiple interactions

Clozapine results in decreased expression of PRPF6 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein

NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991

G

proline-rich coiled-coil 2A

decreases expression

Clozapine results in decreased expression of PRRC2A mRNA

NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130

G

proteasome 20S subunit beta 5

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 7

decreases expression

Clozapine results in decreased expression of PSMB7 protein

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

proteasome 26S subunit, ATPase 3

increases expression

Clozapine results in increased expression of PSMC3 protein

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 5

increases expression

Clozapine results in increased expression of PSMC5 protein

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

proteasome 26S subunit, non-ATPase 14

increases expression

Clozapine results in increased expression of PSMD14 protein

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

proteasome 26S subunit, non-ATPase 7

increases expression

Clozapine results in increased expression of PSMD7 protein

NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588

G

Pentatricopeptide repeat domain 3

increases expression

Clozapine results in increased expression of PTCD3 protein

NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538

G

prostaglandin D2 synthase

decreases expression
increases expression

Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA

PMID:15542763 PMID:17266109

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

protein tyrosine kinase 2

increases expression

Clozapine results in increased expression of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

prothymosin alpha

increases expression

Clozapine results in increased expression of PTMA protein

NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333

G

parathymosin

increases expression

Clozapine results in increased expression of PTMS mRNA

NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009

G

parvalbumin

multiple interactions

Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

PWP2, small subunit processome component

increases expression

Clozapine results in increased expression of PWP2 protein

NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640

G

pyrroline-5-carboxylate reductase 1

increases expression

Clozapine results in increased expression of PYCR1 protein

NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549

G

quinoid dihydropteridine reductase

decreases expression

Clozapine results in decreased expression of QDPR protein

NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854

G

RAB12, member RAS oncogene family

decreases expression

Clozapine results in decreased expression of RAB12 mRNA

NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910

G

Rac family small GTPase 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

receptor for activated C kinase 1

decreases expression

Clozapine results in decreased expression of RACK1 protein

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RALY RNA binding protein-like

increases expression

Clozapine results in increased expression of RALYL protein

NCBI chr 2:87,482,747...88,274,329
Ensembl chr 2:87,482,755...88,274,452

G

RAN, member RAS oncogene family

decreases expression

Clozapine results in decreased expression of RAN protein

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

Rap1 GTPase-GDP dissociation stimulator 1

increases expression

Clozapine results in increased expression of RAP1GDS1 protein

NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169

G

Rap guanine nucleotide exchange factor 4

decreases expression

Clozapine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

Clozapine affects the expression of RASGRF1 mRNA

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

RB binding protein 4, chromatin remodeling factor

decreases expression

Clozapine results in decreased expression of RBBP4 protein

NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284

G

RELA proto-oncogene, NF-kB subunit

decreases expression

Clozapine results in decreased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression
decreases methylation
multiple interactions

Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased methylation of RELN promoter
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]
Clozapine results in decreased expression of RELN protein

PMID:17266109 PMID:18757738 PMID:19359144

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

replication factor C subunit 5

increases expression

Clozapine results in increased expression of RFC5 protein

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

regulator of G-protein signaling 4

increases expression

Clozapine results in increased expression of RGS4 mRNA

PMID:15860345 PMID:17266109

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

regulator of G-protein signaling 7

multiple interactions
increases expression

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA

NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888

G

regulator of G-protein signaling 8

increases expression

Clozapine results in increased expression of RGS8 mRNA

NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807

G

ras homolog family member B

increases expression

Clozapine results in increased expression of RHOB protein

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

RIC8 guanine nucleotide exchange factor A

decreases expression

Clozapine results in decreased expression of RIC8A protein

NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467

G

ring finger protein 13

increases expression

Clozapine results in increased expression of RNF13 protein

NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801

G

ring finger protein 20

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein

NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754

G

RAR-related orphan receptor B

decreases expression

Clozapine results in decreased expression of RORB mRNA

NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390

G

replication protein A1

decreases expression

Clozapine results in decreased expression of RPA1 protein

NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949

G

ribosomal protein L11

increases expression

Clozapine results in increased expression of RPL11 protein

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L19

increases expression

Clozapine results in increased expression of RPL19 protein

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L30

increases expression

Clozapine results in increased expression of RPL30 protein

NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363

G

ribosomal protein L5

increases expression

Clozapine results in increased expression of RPL5 protein

NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290

G

ribosomal protein lateral stalk subunit P0 like 1

decreases expression

Clozapine results in decreased expression of RPLP0P6 protein

NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646

G

ribosomal protein lateral stalk subunit P2

increases expression

Clozapine results in increased expression of RPLP2 mRNA

NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645

G

ribophorin II

decreases expression

Clozapine results in decreased expression of RPN2 protein

NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543

G

ribosomal protein S10

increases expression

Clozapine results in increased expression of RPS10 mRNA

NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
Ensembl chr 6:5,694,313...5,699,044

G

ribosomal protein S11

decreases expression

Clozapine results in decreased expression of RPS11 protein

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S3

decreases expression

Clozapine results in decreased expression of RPS3 protein

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosome binding protein 1

decreases expression

Clozapine results in decreased expression of RRBP1 protein

NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981

G

remodeling and spacing factor 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein

NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051

G

ring finger and SPRY domain containing 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein

NCBI chr19:10,352,449...10,403,015
Ensembl chr19:10,353,821...10,401,102

G

RT1 class Ia, locus A2

increases expression

Clozapine results in increased expression of HLA-E protein

NCBI chr20:4,870,939...4,910,183

G

RNA 2',3'-cyclic phosphate and 5'-OH ligase

increases expression

Clozapine results in increased expression of RTCB protein

NCBI chr 7:17,907,668...17,927,136
Ensembl chr 7:17,907,705...17,927,132

G

reticulon 4

increases expression

Clozapine results in increased expression of RTN4 mRNA

NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686

G

retinoid X receptor gamma

decreases expression

Clozapine results in decreased expression of RXRG mRNA alternative form

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

S100 calcium binding protein A9

decreases expression

Clozapine results in decreased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

scaffold attachment factor B

increases expression

Clozapine results in increased expression of SAFB protein

NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644

G

seryl-tRNA synthetase 1

decreases expression

Clozapine results in decreased expression of SARS1 protein

NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277

G

SATB homeobox 2

increases expression

Clozapine results in increased expression of SATB2 protein

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

sterol-C5-desaturase

increases expression

Clozapine results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

increases expression

Clozapine results in increased expression of SCD mRNA

PMID:16027736 PMID:17052361

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

syndecan binding protein

decreases expression
increases expression

Clozapine results in decreased expression of SDCBP protein
Clozapine results in increased expression of SDCBP protein

PMID:34122009 PMID:36482696

NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572

G

SEC31 homolog A, COPII coat complex component

increases expression

Clozapine results in increased expression of SEC31A protein

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

SEC61 translocon subunit beta

increases expression

Clozapine results in increased expression of SEC61B protein

NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804

G

SEC63 homolog, protein translocation regulator

increases expression

Clozapine results in increased expression of SEC63 protein

NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055

G

septin 14

decreases expression

Clozapine results in decreased expression of SEPTIN14 protein

NCBI chr12:26,975,283...27,005,588
Ensembl chr12:26,975,344...26,998,299

G

serine incorporator 1

increases expression

Clozapine results in increased expression of SERINC1 protein

NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691

G

serpin family A member 3N

increases expression

Clozapine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family E member 2

increases expression

Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

Set nuclear proto-oncogene

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of SET protein

NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567

G

senataxin

increases expression

Clozapine results in increased expression of SETX protein

NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803

G

splicing factor 3b, subunit 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein

NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245

G

splicing factor proline and glutamine rich

decreases expression

Clozapine results in decreased expression of SFPQ protein

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

sideroflexin 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

serum/glucocorticoid regulated kinase 1

increases expression

Clozapine results in increased expression of SGK1 mRNA

PMID:17266109 PMID:18208916

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

SH3 domain containing GRB2 like 1, endophilin A2

increases expression

Clozapine results in increased expression of SH3GL1 protein

NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716

G

SH3 domain-containing kinase-binding protein 1

increases expression

Clozapine results in increased expression of SH3KBP1 protein

NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747

G

SH3 and PX domains 2B

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

SIM bHLH transcription factor 2

decreases expression

Clozapine results in decreased expression of SIM2 protein

NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663

G

sirtuin 2

increases expression

Clozapine results in increased expression of SIRT2 protein

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

S-phase kinase-associated protein 1

decreases expression

Clozapine results in decreased expression of SKP1 protein

NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388

G

solute carrier family 17 member 6

increases expression

Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein

PMID:17266109 PMID:18155072

NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542

G

solute carrier family 17 member 7

increases expression

Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 18 member A2

increases expression

Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 1 member 1

decreases expression

Clozapine results in decreased expression of SLC1A1 mRNA

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 1 member 2

decreases activity
decreases expression

Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein

PMID:11443521 PMID:12873733

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 22 member 2

multiple interactions

Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 5

multiple interactions

Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 13

increases expression

Clozapine results in increased expression of SLC25A13 protein

NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902

G

solute carrier family 25 member 24

increases expression

Clozapine results in increased expression of SLC25A24 protein

NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231

G

solute carrier family 25 member 5, pseudogene 11

increases expression

Clozapine results in increased expression of SLC25A6 protein

NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 2 member 3

decreases expression

Clozapine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 39 member 7

increases expression

Clozapine results in increased expression of SLC39A7 mRNA

NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537

G

solute carrier family 3 member 2

increases expression

Clozapine results in increased expression of SLC3A2 protein

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 2

decreases expression

Clozapine results in decreased expression of SLC6A2 mRNA

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 6 member 3

affects response to substance

SLC6A3 5' UTR affects the susceptibility to Clozapine

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

multiple interactions
affects response to substance
increases expression

[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
SLC6A4 protein affects the susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4

PMID:12007678 PMID:20452607

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

decreases expression

Clozapine results in decreased expression of SMARCB1 protein

NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein

NCBI chr 7:881,844...910,090
Ensembl chr 7:881,421...909,978

G

structural maintenance of chromosomes 2

decreases expression

Clozapine results in decreased expression of SMC2 protein

NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242

G

structural maintenance of chromosomes 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

synaptosome associated protein 25

increases expression
affects response to substance

Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine

PMID:15823421 PMID:15860345

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

small nuclear ribonucleoprotein U5 subunit 200

increases expression

Clozapine results in increased expression of SNRNP200 protein

NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182

G

small nuclear ribonucleoprotein polypeptides B and B1

increases expression

Clozapine results in increased expression of SNRPB protein

NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

Clozapine results in increased expression of SNRPD2 mRNA

NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351

G

sorting nexin 1

decreases expression

Clozapine results in decreased expression of SNX1 protein

NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360

G

sorting nexin 6

increases expression

Clozapine results in increased expression of SNX6 protein

NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911

G

superoxide dismutase 1

increases expression
multiple interactions
decreases expression

Clozapine results in increased expression of SOD1 mRNA
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Clozapine results in decreased expression of SOD1 protein

PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

Clozapine results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

increases expression

Clozapine results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression
increases expression

Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

secreted phosphoprotein 1

decreases expression

Clozapine results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

serine palmitoyltransferase, long chain base subunit 1

decreases expression

Clozapine results in decreased expression of SPTLC1 protein

NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295

G

sequestosome 1

increases expression

Clozapine results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

increases expression
multiple interactions

Clozapine results in increased expression of SREBF1 mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein

PMID:17052361 PMID:19682446 PMID:20564506

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression

Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

serine/arginine repetitive matrix 2

decreases expression

Clozapine results in decreased expression of SRRM2 protein

NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751

G

serine and arginine rich splicing factor 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine and arginine rich splicing factor 5

multiple interactions
increases expression

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

G

serine and arginine rich splicing factor 7

decreases expression

Clozapine results in decreased expression of SRSF7 protein

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

signal sequence receptor subunit 3

decreases expression

Clozapine results in decreased expression of SSR3 protein

NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132

G

somatostatin

multiple interactions

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

stromal interaction molecule 1

decreases expression

Clozapine results in decreased expression of STIM1 protein

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

stress-induced phosphoprotein 1

decreases expression

Clozapine results in decreased expression of STIP1 protein

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

serine/threonine kinase receptor associated protein

decreases expression

Clozapine results in decreased expression of STRAP protein

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

striatin 4

increases expression

Clozapine results in increased expression of STRN4 mRNA

NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858

G

syntaxin 1A

increases expression

Clozapine results in increased expression of STX1A mRNA

NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930

G

syntaxin 1B

increases expression

Clozapine results in increased expression of STX1B mRNA

NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280

G

syntaxin 4

increases expression

Clozapine results in increased expression of STX4 mRNA

NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979

G

syntaxin 8

affects expression

Clozapine affects the expression of STX8 mRNA

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

syntaxin binding protein 1

affects expression

Clozapine affects the expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

succinate-CoA ligase ADP-forming subunit beta

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

Clozapine results in decreased expression of SUCLG1 protein

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600

G

SPT3 homolog, SAGA and STAGA complex component

increases expression

Clozapine results in increased expression of SUPT3H mRNA

NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706

G

synapsin II

decreases expression
increases expression

Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA

PMID:15860345 PMID:17266109

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

Clozapine results in decreased expression of SYNCRIP protein

NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515

G

synaptotagmin 11

increases expression

Clozapine results in increased expression of SYT11 mRNA

NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964

G

synaptotagmin 2

increases expression

Clozapine results in increased expression of SYT2 mRNA

NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859

G

synaptotagmin 4

increases expression

Clozapine results in increased expression of SYT4 mRNA

NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332

G

synaptotagmin 5

decreases expression

Clozapine results in decreased expression of SYT5 mRNA

NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067

G

tachykinin, precursor 1

decreases expression

Clozapine results in decreased expression of TAC1 mRNA

PMID:10974607 PMID:17266109

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transgelin

decreases expression

Clozapine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17175557

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transgelin 2

decreases expression

Clozapine results in decreased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

TAO kinase 2

increases expression

Clozapine results in increased expression of TAOK2 protein

NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613

G

TatD DNase domain containing 1

increases expression

Clozapine results in increased expression of TATDN1 mRNA

NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133

G

TBC1 domain family, member 15

increases expression

Clozapine results in increased expression of TBC1D15 protein

NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175

G

TBC1 domain family member 8B

increases expression

Clozapine results in increased expression of TBC1D8B protein

NCBI chr X:103,319,181...103,407,137
Ensembl chr X:103,319,340...103,407,133

G

tubulin folding cofactor B

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein

NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488

G

transducin (beta)-like 3

increases expression

Clozapine results in increased expression of TBL3 protein

NCBI chr10:13,726,127...13,731,340
Ensembl chr10:13,726,129...13,731,372

G

TRPM8 channel-associated factor 1

decreases expression

Clozapine results in decreased expression of TCAF1 protein

NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309

G

testin LIM domain protein

decreases expression

Clozapine results in decreased expression of TES protein

NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829

G

trans-golgi network protein 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein

NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164

G

tyrosine hydroxylase

decreases activity
multiple interactions
increases activity
decreases expression
increases expression

Clozapine results in decreased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased expression of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]

PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

thyroid hormone receptor alpha

decreases expression
increases expression

Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor associated protein 3

decreases expression

Clozapine results in decreased expression of THRAP3 protein

NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477

G

thyroid hormone receptor beta

decreases expression

Clozapine results in decreased expression of THRB mRNA alternative form

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

talin 2

decreases expression

Clozapine results in decreased expression of TLN2 protein

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

transmembrane 9 superfamily member 2

decreases expression

Clozapine results in decreased expression of TM9SF2 protein

NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049

G

transmembrane p24 trafficking protein 10

decreases expression

Clozapine results in decreased expression of TMED10 protein

NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753

G

transmembrane protein 109

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein

NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215

G

thymopoietin

decreases expression

Clozapine results in decreased expression of TMPO protein

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

tumor necrosis factor

affects response to substance
increases expression
multiple interactions
increases secretion

TNF protein affects the susceptibility to Clozapine
Clozapine results in increased expression of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]

PMID:20521320 PMID:24709159 PMID:34935985

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 15

decreases expression

Clozapine results in decreased expression of TNFSF15 mRNA

NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228

G

TRAF2 an