dihydroxyanthraquinone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dihydroxyanthraquinone	go back to main search page
Accession:	CHEBI:37484	browse the term
Synonyms:	exact_synonym:	dihydroxyanthracene-9,10-dione
	related_synonym:	Formula=C14H8O4; dihydroxy-9,10-anthracenedione; dihydroxy-9,10-anthraquinone
	xref:	CAS:1322-60-7

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Rat (354) Mouse (358) Human (374) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (354)

2-hydroxychrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions

CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases chemical synthesis

[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

Alizarin Red S binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

alizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
multiple interactions

alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]

PMID:12379470 PMID:37515497

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

alizarin results in decreased activity of CYP1A2 protein

PMID:12379470 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

alizarin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

alizarin results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

estrogen receptor 1

multiple interactions

alizarin binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

H2A.X variant histone

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

mitogen activated protein kinase 1

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]

PMID:33421718 PMID:38670245

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

N-acetyltransferase 1

decreases activity

alizarin results in decreased activity of NAT1 protein

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of alizarin

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of alizarin

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of alizarin

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

Aloe emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

aldo-keto reductase family 1 member B10

decreases activity

aloe emodin results in decreased activity of AKR1B10 protein

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C3

decreases activity

aloe emodin results in decreased activity of AKR1C3 protein

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

activating transcription factor 3

increases expression

aloe emodin results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression

aloe emodin results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein

PMID:19928967 PMID:22210228

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
multiple interactions
increases cleavage
increases expression

aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein

PMID:19928967 PMID:22210228

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity
multiple interactions
increases expression

aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases expression
multiple interactions

aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

carbonyl reductase 1

decreases activity

aloe emodin results in decreased activity of CBR1 protein

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cytochrome c, somatic

increases expression

aloe emodin results in increased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

aloe emodin results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

aloe emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

aloe emodin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases chemical synthesis

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

aloe emodin results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

increases expression

aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

aloe emodin results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

fatty acid binding protein 4

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of FADD protein

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

increases expression

aloe emodin results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

aloe emodin results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

heat shock protein family A (Hsp70) member 5

increases expression

aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

lipoprotein lipase

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

N-acetyltransferase 1

multiple interactions
decreases expression

aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

nitric oxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

peroxisome proliferator-activated receptor gamma

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

resistin

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA]

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

sulfotransferase family 1A member 1

decreases activity

aloe emodin results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

decreases activity

aloe emodin results in decreased activity of SULT1E1 protein

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

tumor necrosis factor

multiple interactions
increases expression

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein

PMID:19928967 PMID:22645054

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

aloe emodin results in increased expression of TNFRSF1A protein

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

increases expression

aloe emodin results in increased expression of TNFRSF1B protein

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

tumor protein p53

increases expression

aloe emodin results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of TRADD protein

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of aloe emodin

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

X-box binding protein 1

increases splicing

aloe emodin results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

anthraflavic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects binding

2,6-dihydroxyanthraquinone binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

PMID:12756209 PMID:14557274

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

chrysazin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases expression

danthron affects the localization of and results in increased expression of AIFM1 protein
danthron results in increased expression of AIFM1 mRNA

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

albumin

affects binding

danthron binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activating transcription factor 6

increases expression

danthron results in increased expression of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

increases expression

danthron results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

danthron results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
decreases expression

danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases expression

danthron results in increased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

decreases expression

danthron results in decreased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

increases expression

danthron results in increased expression of BIRC3 protein

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

danthron results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions
increases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases expression

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases expression

benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytochrome c, somatic

multiple interactions

danthron affects the localization of and results in increased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

danthron results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

DNA-damage inducible transcript 3

increases expression

danthron results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

diablo, IAP-binding mitochondrial protein

increases expression

danthron results in increased expression of DIABLO protein

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

endonuclease G

increases expression
multiple interactions

danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

Fas cell surface death receptor

increases expression

danthron results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

danthron results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

heat shock protein family A (Hsp70) member 5

increases expression

danthron results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

superoxide dismutase 1

decreases expression

danthron results in decreased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

danthron results in decreased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

TNF superfamily member 10

increases expression

danthron results in increased expression of TNFSF10 protein

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

X-linked inhibitor of apoptosis

decreases expression

danthron results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

chrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

increases expression

chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

increases expression

chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

aryl hydrocarbon receptor

multiple interactions

chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2-antagonist/killer 1

increases expression

chrysophanic acid results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression

chrysophanic acid results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

chrysophanic acid results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases metabolic processing

chrysophanic acid results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

PMID:27633141 PMID:29698620 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

chrysophanic acid results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased metabolism of chrysophanic acid
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

increases expression

chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

DNA-damage inducible transcript 3

increases expression

chrysophanic acid results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2AK3 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

increases expression

chrysophanic acid results in increased expression of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

mitogen activated protein kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

proliferating cell nuclear antigen

decreases expression

chrysophanic acid results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

ribosomal protein S6

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 10 member 1

decreases expression

chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 22 member 6

decreases activity

chrysophanic acid results in decreased activity of SLC22A6 protein

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

chrysophanic acid results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

sulfotransferase family 1A member 1

decreases activity

chrysophanic acid results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of chrysophanic acid

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

mitoxantrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects response to substance

ABCA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Mitoxantrone results in increased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 2

affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
affects uptake
affects transport
increases response to substance

ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [GSK 1363089 results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; GSK 1363089 inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone

PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA dehydrogenase, very long chain

decreases expression

Mitoxantrone results in decreased expression of ACADVL protein

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

acyl-CoA synthetase long-chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin, alpha 1, skeletal muscle

decreases expression

Mitoxantrone results in decreased expression of ACTA1 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin gamma 2, smooth muscle

affects response to substance

ACTG2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

adenosine deaminase, RNA-specific, B1

affects response to substance

ADARB1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852

G

1-acylglycerol-3-phosphate O-acyltransferase 5

affects response to substance

AGPAT5 protein affects the susceptibility to Mitoxantrone

NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560

G

adenosylhomocysteinase-like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

aldehyde dehydrogenase 2 family member

affects response to substance

ALDH2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

angiomotin-like 1

affects response to substance

AMOTL1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573

G

ankyrin 2

decreases expression

Mitoxantrone results in decreased expression of ANK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

G

asparagine synthetase (glutamine-hydrolyzing)

affects response to substance

ASNS protein affects the susceptibility to Mitoxantrone

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

affects response to substance

ASS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

autophagy related 5

decreases expression

Mitoxantrone results in decreased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

decreases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein

PMID:22832221 PMID:29913208

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Mitoxantrone results in decreased expression of ATP1A2 mRNA

PMID:26537877 PMID:28940058

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATP synthase F1 subunit alpha

decreases expression

Mitoxantrone results in decreased expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

decreases expression

Mitoxantrone results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

decreases expression

Mitoxantrone results in decreased expression of ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Mitoxantrone

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression

Mitoxantrone results in increased expression of BAX mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BBX high mobility group box domain containing

affects response to substance

BBX protein affects the susceptibility to Mitoxantrone

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

G

basal cell adhesion molecule (Lutheran blood group)

affects response to substance

BCAM protein affects the susceptibility to Mitoxantrone

NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403

G

branched chain amino acid transaminase 1

increases expression

Mitoxantrone results in increased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA

PMID:8219202 PMID:8840993 PMID:15582267

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

decreases expression

Mitoxantrone results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 2

decreases expression

Mitoxantrone results in decreased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

affects expression
increases expression

Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

affects response to substance

BMP7 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone marrow stromal cell antigen 2

affects response to substance

BST2 protein affects the susceptibility to Mitoxantrone

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BTB domain containing 3

affects response to substance

BTBD3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038

G

calcium voltage-gated channel subunit alpha1 G

decreases expression

Mitoxantrone results in decreased expression of CACNA1G mRNA

PMID:26537877 PMID:28940058

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Mitoxantrone results in decreased expression of CACNA2D2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173

G

calreticulin

affects localization

Mitoxantrone affects the localization of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

affects response to substance

CAMK2N1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

CASC3 exon junction complex subunit

affects response to substance

CASC3 mRNA affects the susceptibility to Mitoxantrone

NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966

G

caspase 2

increases expression
increases splicing

Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]

PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases activity

Mitoxantrone results in increased activity of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases activity
multiple interactions

Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]

PMID:12948851 PMID:22700542

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases activity

Mitoxantrone results in increased activity of CASP8 protein

PMID:12948851 PMID:32894303

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Mitoxantrone results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity

Mitoxantrone results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolae associated protein 3

affects response to substance

CAVIN3 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161

G

caveolae associated protein 4

decreases expression

Mitoxantrone results in decreased expression of CAVIN4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:62,996,906...63,007,677
Ensembl chr 5:62,996,865...63,007,678

G

CD55 molecule (Cromer blood group)

affects response to substance

CD55 protein affects the susceptibility to Mitoxantrone

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

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CUGBP, Elav-like family member 2

affects response to substance

CELF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

centrosomal protein 15

affects response to substance

CEP15 protein affects the susceptibility to Mitoxantrone

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

carboxylesterase 2H

affects response to substance

CES2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

chordin-like 1

affects response to substance

CHRDL1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

G

chemokine-like factor

affects response to substance

CKLF protein affects the susceptibility to Mitoxantrone

NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570

G

creatine kinase, M-type

decreases expression

Mitoxantrone results in decreased expression of CKM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

chloride nucleotide-sensitive channel 1A

affects response to substance

CLNS1A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661

G

clusterin

affects response to substance

CLU protein affects the susceptibility to Mitoxantrone

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cochlin

affects response to substance

COCH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

G

collagen type XI alpha 1 chain

affects response to substance

COL11A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

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corin, serine peptidase

decreases expression

Mitoxantrone results in decreased expression of CORIN mRNA

PMID:26537877 PMID:28940058

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

carboxypeptidase, vitellogenic-like

affects response to substance

CPVL protein affects the susceptibility to Mitoxantrone

NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655

G

cAMP responsive element binding protein-like 2

affects response to substance

CREBL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292

G

citrate synthase

decreases activity

Mitoxantrone results in decreased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cysteine and serine rich nuclear protein 2

affects response to substance

CSRNP2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075

G

cystathionine gamma-lyase

affects response to substance

CTH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

CXADR, Ig-like cell adhesion molecule

affects response to substance

CXADR protein affects the susceptibility to Mitoxantrone

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

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cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

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cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

death associated protein kinase 1

affects response to substance

DAPK1 protein affects the susceptibility to Mitoxantrone

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DNA-damage-inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitoxantrone

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

dehydrogenase/reductase 2

affects response to substance

DHRS2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

affects response to substance

DIS3 protein affects the susceptibility to Mitoxantrone

NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642

G

dystrophin

decreases expression

Mitoxantrone results in decreased expression of DMD mRNA

PMID:26537877 PMID:28940058

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

dual specificity phosphatase 4

affects response to substance
increases expression

DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA

PMID:16217747 PMID:26537877 PMID:28940058

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity tyrosine phosphorylation regulated kinase 2

affects response to substance

DYRK2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

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early growth response 1

affects response to substance

EGR1 protein affects the susceptibility to Mitoxantrone

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit alpha

affects response to substance

EIF2S1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5A

affects response to substance

EIF5A protein affects the susceptibility to Mitoxantrone

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ELAV like RNA binding protein 4

affects response to substance

ELAVL4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446

G

ELOVL fatty acid elongase 5

affects response to substance

ELOVL5 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

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engrailed homeobox 2

affects response to substance

EN2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943

G

ectodermal-neural cortex 1

affects response to substance

ENC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

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erythrocyte membrane protein band 4.1-like 2

affects response to substance

EPB41L2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

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erb-b2 receptor tyrosine kinase 3

decreases expression

Mitoxantrone results in decreased expression of ERBB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

electron transfer flavoprotein dehydrogenase

decreases expression

Mitoxantrone results in decreased expression of ETFDH protein

NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745

G

ecotropic viral integration site 5

affects response to substance

EVI5 protein affects the susceptibility to Mitoxantrone

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

exostosin-like glycosyltransferase 2

affects response to substance

EXTL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653

G

fatty acid binding protein 3

increases expression

Mitoxantrone results in increased expression of FABP3 protein

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

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family with sequence similarity 117, member A

affects response to substance

FAM117A protein affects the susceptibility to Mitoxantrone

NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343

G

Fas cell surface death receptor

multiple interactions
increases expression

Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein

PMID:9676859 PMID:26537877 PMID:28940058

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases response to substance
multiple interactions

FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

farnesyl diphosphate farnesyl transferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

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four and a half LIM domains 1

increases expression

Mitoxantrone results in increased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

fibronectin leucine rich transmembrane protein 3

affects response to substance

FLRT3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

fibronectin type III domain containing 3a

affects response to substance

FNDC3A protein affects the susceptibility to Mitoxantrone

NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784

G

forkhead box F2

affects response to substance

FOXF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitoxantrone

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 2

affects response to substance

FZD2 protein affects the susceptibility to Mitoxantrone

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

GTP cyclohydrolase 1

affects response to substance

GCH1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

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growth differentiation factor 15

increases expression

Mitoxantrone results in increased expression of GDF15 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamate-ammonia ligase

affects response to substance

GLUL protein affects the susceptibility to Mitoxantrone

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutathione peroxidase 1

increases expression

Mitoxantrone results in increased expression of GPX1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

affects response to substance

GPX3 protein affects the susceptibility to Mitoxantrone

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

guanylate cyclase 1 soluble subunit beta 1

affects response to substance

GUCY1B1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]

PMID:19738048 PMID:24994473 PMID:29913208

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

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hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Mitoxantrone results in decreased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 4

affects response to substance

HDAC4 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

high mobility group 20 B

affects response to substance

HMG20B protein affects the susceptibility to Mitoxantrone

NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640

G

homeo box A5

affects response to substance

HOXA5 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

G

histidine rich calcium binding protein

decreases expression

Mitoxantrone results in decreased expression of HRC mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

G

heat shock protein family A (Hsp70) member 2

affects response to substance

HSPA2 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects response to substance
decreases expression

IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein

PMID:16217747 PMID:34246718

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

interferon induced transmembrane protein 1

affects response to substance

IFITM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Mitoxantrone

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

insulin-like growth factor binding protein 3

affects response to substance

IGFBP3 protein affects the susceptibility to Mitoxantrone

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 7

affects response to substance

IGFBP7 protein affects the susceptibility to Mitoxantrone

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Mitoxantrone

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

inner membrane mitochondrial protein

decreases expression

Mitoxantrone results in decreased expression of IMMT protein

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

IQ motif containing GTPase activating protein 1

affects response to substance

IQGAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

interferon regulatory factor 7

affects response to substance

IRF7 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

iroquois homeobox 1

affects response to substance

IRX1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444

G

iroquois homeobox 4

decreases expression

Mitoxantrone results in decreased expression of IRX4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549

G

ISG15 ubiquitin-like modifier

affects response to substance

ISG15 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

affects response to substance

ISG20 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

Janus kinase 2

decreases expression

Mitoxantrone results in decreased expression of JAK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

KCNAB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243

G

potassium voltage-gated channel subfamily H member 2

decreases expression

Mitoxantrone results in decreased expression of KCNH2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 2

increases expression

Mitoxantrone results in increased expression of KCNJ2 mRNA

PMID:26537877 PMID:28940058

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

potassium voltage-gated channel subfamily Q member 1

decreases expression

Mitoxantrone results in decreased expression of KCNQ1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

KRR1, small subunit processome component homolog

affects response to substance

KRR1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985

G

laminin subunit alpha 2

affects response to substance

LAMA2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530

G

laminin subunit beta 1

affects response to substance

LAMB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit gamma 1

affects response to substance

LAMC1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

LBH regulator of WNT signaling pathway

affects response to substance

LBH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

G

LIM domain binding 3

decreases expression

Mitoxantrone results in decreased expression of LDB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532

G

LEM domain nuclear envelope protein 2

affects response to substance

LEMD2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626

G

leucine-rich repeat-containing G protein-coupled receptor 4

affects response to substance

LGR4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899

G

lipase A, lysosomal acid type

affects response to substance

LIPA protein affects the susceptibility to Mitoxantrone

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

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lipase G, endothelial type

affects response to substance

LIPG protein affects the susceptibility to Mitoxantrone

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

LIM and cysteine-rich domains 1

increases expression

Mitoxantrone results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

lamin B1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

mono-ADP ribosylhydrolase 1

affects response to substance

MACROD1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716

G

MAF bZIP transcription factor F

affects response to substance

MAFF mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member D1

affects response to substance

MAGED1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:59,422,715...59,429,381
Ensembl chr X:59,422,717...59,429,364

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

malate dehydrogenase 2

decreases expression

Mitoxantrone results in decreased expression of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

MDM2 proto-oncogene

decreases response to substance

MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mesoderm specific transcript

affects response to substance

MEST protein affects the susceptibility to Mitoxantrone

NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145

G

molybdenum cofactor sulfurase

affects response to substance

MOCOS protein affects the susceptibility to Mitoxantrone

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

mitochondrial pyruvate carrier 2

affects response to substance

MPC2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects response to substance

MTHFD2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

MAX interactor 1, dimerization protein

affects response to substance

MXI1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYC binding protein 2

affects response to substance

MYCBP2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498

G

myosin heavy chain 6

decreases expression

Mitoxantrone results in decreased expression of MYH6 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

decreases expression

Mitoxantrone results in decreased expression of MYH7 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myomesin 2

decreases expression

Mitoxantrone results in decreased expression of MYOM2 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

nicotinamide phosphoribosyltransferase

affects response to substance

NAMPT protein affects the susceptibility to Mitoxantrone

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

NADH:ubiquinone oxidoreductase subunit S5

affects response to substance

NDUFS5 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

neurofilament heavy chain

affects response to substance

NEFH protein affects the susceptibility to Mitoxantrone

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nidogen 2

affects response to substance

NID2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843

G

nuclear receptor subfamily 3, group C, member 1

decreases activity

Mitoxantrone results in decreased activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

affects response to substance

NR4A2 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nebulin-related anchoring protein

decreases expression

Mitoxantrone results in decreased expression of NRAP mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

3-oxoacid CoA transferase 1

affects response to substance

OXCT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714

G

prolyl 4-hydroxylase subunit alpha 1

affects response to substance

P4HA1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

parkin coregulated like

affects response to substance

PACRGL mRNA affects the susceptibility to Mitoxantrone

NCBI chr14:62,532,019...62,556,977
Ensembl chr14:62,532,030...62,556,993

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

PMID:8840993 PMID:15582267

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PBX homeobox 1

affects response to substance

PBX1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

G

phosphodiesterase 4D

affects response to substance

PDE4D protein affects the susceptibility to Mitoxantrone

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 8A

affects response to substance

PDE8A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

Mitoxantrone results in decreased expression of PDHA1 protein

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

G

prohibitin 2

decreases expression

Mitoxantrone results in decreased expression of PHB2 protein

NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272

G

phosphoglycerate dehydrogenase

affects response to substance

PHGDH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

PLAG1 like zinc finger 1

affects response to substance

PLAGL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

G

plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Mitoxantrone

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase C, beta 4

affects response to substance

PLCB4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392

G

pyridoxal phosphate binding protein

affects response to substance

PLPBP protein affects the susceptibility to Mitoxantrone

NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886

G

PML nuclear body scaffold

affects mutagenesis

Mitoxantrone affects the mutagenesis of PML gene

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

affects response to substance

PPP1R2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463

G

protein phosphatase 1, regulatory subunit 3A

decreases expression

Mitoxantrone results in decreased expression of PPP1R3A mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638

G

PR/SET domain 16

decreases expression

Mitoxantrone results in decreased expression of PRDM16 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601

G

peroxiredoxin 2

affects response to substance

PRDX2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

PRELI domain containing 3B

affects response to substance

PRELID3B protein affects the susceptibility to Mitoxantrone

NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181

G

protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

Mitoxantrone results in increased expression of PRKX mRNA

PMID:26537877 PMID:28940058

NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669

G

protein tyrosine phosphatase, receptor type, E

affects response to substance

PTPRE protein affects the susceptibility to Mitoxantrone

NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534

G

glycogen phosphorylase, muscle associated

decreases expression

Mitoxantrone results in decreased expression of PYGM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

retinoic acid receptor, alpha

affects mutagenesis

Mitoxantrone affects the mutagenesis of RARA gene

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

Mitoxantrone results in increased expression of RARB mRNA alternative form

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAS p21 protein activator 1

affects response to substance

RASA1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB binding protein 8, endonuclease

affects response to substance

RBBP8 protein affects the susceptibility to Mitoxantrone

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RNA binding motif protein 17

multiple interactions
decreases response to substance

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014

G

RCC1 and BTB domain containing protein 1

affects response to substance

RCBTB1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:33,319,586...33,362,421
Ensembl chr15:33,319,586...33,365,302

G

ring finger and CHY zinc finger domain containing 1

affects response to substance

RCHY1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167

G

regulator of G-protein signaling 2

affects response to substance

RGS2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

Rho family GTPase 1

increases expression

Mitoxantrone results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

Ras-related GTP binding D

affects response to substance

RRAGD mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356

G

RUNX family transcription factor 3

affects response to substance

RUNX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

ryanodine receptor 2

decreases expression

Mitoxantrone results in decreased expression of RYR2 mRNA

PMID:26537877 PMID:28940058

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

spalt-like transcription factor 2

affects response to substance

SALL2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:25,021,345...25,038,918
Ensembl chr15:25,021,345...25,038,918

G

SATB homeobox 2

affects response to substance

SATB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

stearoyl-CoA desaturase

affects response to substance

SCD protein affects the susceptibility to Mitoxantrone

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

schwannomin interacting protein 1

affects response to substance

SCHIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585

G

sodium voltage-gated channel beta subunit 2

decreases expression

Mitoxantrone results in decreased expression of SCN2B mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 5

decreases expression

Mitoxantrone results in decreased expression of SCN5A mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

syndecan 2

affects response to substance

SDC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

SEC31 homolog A, COPII coat complex component

affects response to substance

SEC31A protein affects the susceptibility to Mitoxantrone

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

serpin family E member 1

increases expression

Mitoxantrone results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

stratifin

affects response to substance

SFN protein affects the susceptibility to Mitoxantrone

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

secreted frizzled-related protein 4

affects response to substance

SFRP4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

solute carrier family 16, member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitoxantrone

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 25 member 11

decreases expression

Mitoxantrone results in decreased expression of SLC25A11 protein

NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410

G

solute carrier family 7 member 5

affects response to substance

SLC7A5 protein affects the susceptibility to Mitoxantrone

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 4a1

affects response to substance

SLCO4A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

SMAD family member 2

affects response to substance

SMAD2 protein affects the susceptibility to Mitoxantrone

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

spondin 1

affects response to substance

SPON1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

spondin 2

affects response to substance

SPON2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996

G

secreted phosphoprotein 1

increases expression

Mitoxantrone results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

affects expression
decreases expression

Mitoxantrone affects the expression of SQSTM1 protein
Mitoxantrone metabolite results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Mitoxantrone results in decreased expression of SUCLA2 protein

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

synaptotagmin-like 2

affects response to substance

SYTL2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222

G

transgelin

affects response to substance

TAGLN protein affects the susceptibility to Mitoxantrone

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

TBC1 domain family, member 8

affects response to substance

TBC1D8 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 2

increases expression

Mitoxantrone results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

TIA1 cytotoxic granule-associated RNA binding protein

affects response to substance

TIA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586

G

TIMP metallopeptidase inhibitor 1

increases expression

Mitoxantrone results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 47

affects response to substance

TMEM47 protein affects the susceptibility to Mitoxantrone

NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900

G

tankyrase

affects response to substance

TNKS protein affects the susceptibility to Mitoxantrone

NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260

G

troponin T1, slow skeletal type

decreases expression

Mitoxantrone results in decreased expression of TNNT1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

G

tumor protein p53

affects activity

Mitoxantrone affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622

G

tropomyosin 1

affects response to substance

TPM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tribbles pseudokinase 1

affects response to substance

TRIB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tripartite motif-containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927

G

ubiquitin-like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitoxantrone

NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

ubiquinol-cytochrome c reductase hinge protein

affects response to substance

UQCRH protein affects the susceptibility to Mitoxantrone

NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242

G

utrophin

affects response to substance

UTRN protein affects the susceptibility to Mitoxantrone

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

versican

affects response to substance

VCAN protein affects the susceptibility to Mitoxantrone

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

voltage-dependent anion channel 1

decreases expression

Mitoxantrone results in decreased expression of VDAC1 protein

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

tryptophanyl-tRNA synthetase 1

affects response to substance

WARS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WASH complex subunit 3

affects response to substance

WASHC3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696

G

X-linked inhibitor of apoptosis

affects localization
decreases expression

Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

Mitoxantrone results in increased expression of YWHAE protein

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

zinc finger AN1-type containing 1

affects response to substance

ZFAND1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger, matrin type 3

increases expression

Mitoxantrone results in increased expression of ZMAT3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger and SCAN domain containing 18

affects response to substance

ZSCAN18 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897

Obtusifolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 6

decreases activity

obtusifolin results in decreased activity of SLC22A6 protein

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

obtusifolin results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

physcion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression

physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

decreases expression

physcione results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

decreases expression

physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression

physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

physcione results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

physcione results in decreased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases hydroxylation

CYP2B6 protein results in increased hydroxylation of physcione

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases hydroxylation

CYP2C19 protein results in increased hydroxylation of physcione

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation

CYP3A4 protein results in increased hydroxylation of physcione

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

solute carrier family 10 member 1

decreases expression

physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

sulfotransferase family 1A member 1

decreases activity

physcione results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of physcione

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

quinizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects binding

1,4-dihydroxyanthraquinone binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

1,4-dihydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

estrogen receptor 1

multiple interactions

1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Rhein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

actin alpha 2, smooth muscle

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

aryl hydrocarbon receptor

multiple interactions

rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

decreases activity

rhein results in decreased activity of ALKBH2 protein

NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914

G

BCL2 associated X, apoptosis regulator

increases expression

rhein results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

beclin 1

decreases expression

rhein results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases expression

rhein results in decreased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

rhein results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases expression

rhein results in decreased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

rhein results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

rhein results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

rhein results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

rhein results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

epidermal growth factor

decreases expression

rhein results in decreased expression of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

erb-b2 receptor tyrosine kinase 2

decreases expression

rhein results in decreased expression of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

glutamic--pyruvic transaminase

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interferon gamma

increases expression
multiple interactions

rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

increases expression

rhein results in increased expression of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

rhein results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:26784856 PMID:37023836

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 4

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

kinase insert domain receptor

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

midkine

multiple interactions

rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

nuclear factor kappa B subunit 1

affects localization
multiple interactions
decreases activity

rhein affects the localization of NFKB1 protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]
rhein results in decreased activity of NFKB1 protein

PMID:21457705 PMID:37023836

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

prostaglandin-endoperoxide synthase 2

decreases expression

rhein results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

decreases activity
multiple interactions
affects localization

rhein results in decreased activity of RELA protein
rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]

PMID:21457705 PMID:36731809 PMID:37023836

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 6

multiple interactions

rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

sequestosome 1

increases expression

rhein results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sulfotransferase family 1A member 1

decreases activity

rhein results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

TEK receptor tyrosine kinase

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transforming growth factor, beta 1

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
multiple interactions

rhein results in increased expression of TNF protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:26784856 PMID:31436023 PMID:37023836

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNFRSF1A-associated via death domain

increases expression

rhein results in increased expression of TRADD protein

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

TNF receptor-associated factor 1

increases expression

rhein results in increased expression of TRAF1 protein

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

vascular endothelial growth factor A

decreases expression
multiple interactions
decreases response to substance

rhein results in decreased expression of VEGFA protein
rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]
rhein results in decreased susceptibility to VEGFA protein

PMID:21457705 PMID:36731809

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

rubiadin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin receptor

decreases expression

rubiadin results in decreased expression of CALCR mRNA

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

carbonic anhydrase 2

decreases expression

rubiadin results in decreased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

cathepsin K

increases activity

rubiadin results in increased activity of CTSK protein

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

rubiadin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

rubiadin results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

rubiadin results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

NFKB inhibitor alpha

multiple interactions

rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

TNF receptor superfamily member 11B

increases expression

rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

decreases expression
multiple interactions

rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19899
chemical entity	19897
molecular entity	19897
polyatomic entity	19849
heteroatomic molecular entity	19806
hydroxides	19366
organic hydroxy compound	18975
phenols	18678
hydroxyanthraquinones	510
dihydroxyanthraquinone	354
1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3-dihydroxy-6-methoxy-2-methyl-9,10-anthraquinone	0
1,4-dihydroxy-2-methylanthraquinone	0
1,6-dihydroxy-2-methyl-9,10-anthraquinone	0
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	1
4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside	0
Aloe emodin	39
Alterporriol G and H (Atropisomers)	0
DRAQ5 dye	0
Emodin 8-glucoside	0
Lucidin	0
Lucidin omega-methyl ether	0
Obtusifolin	2
Obtusin	0
Purpurin 1-methyl ether	0
Questinol	0
Rhein	43
aklanonic acid +	0
alizarin +	13
alizarin complexone	0
anthraflavic acid	6
anthrarufin	0
aurantio-obtusin beta-D-glucoside	0
chrysazin +	73
chrysophanol +	30
dihydro-nogalonic acid methyl ester	0
gaboroquinone A	0
isoanthraflavin	0
knipholone +	0
methyl aklanonate	0
methyl nogalonate	0
mitoxantrone +	256
nogalonic acid +	0
nuclear fast red free acid	0
physcion +	14
questin	0
quinizarin	6
rubiadin	9
rubianthraquinone	0
scutianthraquinone A	0
scutianthraquinone B	0
scutianthraquinone C	0
variecolorquinone A	0
xanthopurpurin	0
Path 2
Term	Annotations
CHEBI ontology	19899
subatomic particle	19897
composite particle	19897
hadron	19897
baryon	19897
nucleon	19897
atomic nucleus	19897
atom	19897
main group element atom	19835
p-block element atom	19835
carbon group element atom	19776
carbon atom	19772
organic molecular entity	19772
heteroorganic entity	19532
organochalcogen compound	19293
organooxygen compound	19209
carbonyl compound	18933
ketone	17278
cyclic ketone	15924
quinone	9911
acenoquinone	7729
anthraquinone	522
hydroxyanthraquinones	510
dihydroxyanthraquinone	354
1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3-dihydroxy-6-methoxy-2-methyl-9,10-anthraquinone	0
1,4-dihydroxy-2-methylanthraquinone	0
1,6-dihydroxy-2-methyl-9,10-anthraquinone	0
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	1
4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside	0
Aloe emodin	39
Alterporriol G and H (Atropisomers)	0
DRAQ5 dye	0
Emodin 8-glucoside	0
Lucidin	0
Lucidin omega-methyl ether	0
Obtusifolin	2
Obtusin	0
Purpurin 1-methyl ether	0
Questinol	0
Rhein	43
aklanonic acid +	0
alizarin +	13
alizarin complexone	0
anthraflavic acid	6
anthrarufin	0
aurantio-obtusin beta-D-glucoside	0
chrysazin +	73
chrysophanol +	30
dihydro-nogalonic acid methyl ester	0
gaboroquinone A	0
isoanthraflavin	0
knipholone +	0
methyl aklanonate	0
methyl nogalonate	0
mitoxantrone +	256
nogalonic acid +	0
nuclear fast red free acid	0
physcion +	14
questin	0
quinizarin	6
rubiadin	9
rubianthraquinone	0
scutianthraquinone A	0
scutianthraquinone B	0
scutianthraquinone C	0
variecolorquinone A	0
xanthopurpurin	0

paths to the root