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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:crown amine
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Accession:CHEBI:37411 term browser browse the term
Definition:Crown compounds containing only nitrogen as coordinating atom.
Synonyms:related_synonym: crown amines;   polyamine coronand;   polyamine coronands



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1,4,7-triazonane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases expression ISO 1,4,7-triazacyclononane results in decreased expression of CAT protein CTD PMID:32869927 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO 1,4,7-triazacyclononane results in increased expression of GPX1 protein CTD PMID:32869927 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 1,4,7-triazacyclononane results in increased expression of NFE2L2 protein CTD PMID:32869927 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
plerixafor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:18660423 PMID:29510123 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]
plerixafor increases expression of CDH1 protein in lymph node and prostate epithelium
CTD
RGD
PMID:28844962 PMID:30537000 RGD:152025215 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO plerixafor decreases expression of CDH2 protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression
ISO plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
plerixafor results in decreased expression of CXCL12 mRNA
CTD PMID:12220670 PMID:18660423 PMID:24157575 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases activity
decreases phosphorylation
decreases expression
multiple interactions
ISO
EXP
plerixafor results in decreased activity of CXCR4 protein
plerixafor decreases phosphorylation of CXCR4 protein in lymph node and prostate epithelium
plerixafor decreases expression of CXCR4 mRNA and protein in lymph node and prostate epithelium
Plerixafor decreases expression of CXCR4 protein in liver
plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
plerixafor results in decreased expression of CXCR4 protein
CTD
RGD
PMID:12220670 PMID:17121897 PMID:28844962 PMID:30537000 PMID:30537000 More... RGD:152025215, RGD:152025215, RGD:151893463 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor]
plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
CTD PMID:22418586 PMID:25815440 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin decreases expression ISO plerixafor decreases expression on VIM protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                organonitrogen heterocyclic compound 18546
                  crown amine 12
                    1,4,7,10-tetraazacyclododecane + 0
                    1,4,7-triazonane 3
                    1,4,8,11-tetraazacyclotetradecane + 9
                    flotufolastat F-18 0
                    plerixafor 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  crown compound 12
                                    crown amine 12
                                      1,4,7,10-tetraazacyclododecane + 0
                                      1,4,7-triazonane 3
                                      1,4,8,11-tetraazacyclotetradecane + 9
                                      flotufolastat F-18 0
                                      plerixafor 9
paths to the root