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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-hydroxyisovaleric acid
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Accession:CHEBI:37084 term browser browse the term
Definition:A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms:exact_synonym: 3-hydroxy-3-methylbutanoic acid
 related_synonym: 3-OH-isovaleric acid;   3-hydroxy-3-methylbutyric acid;   3-hydroxy-isovaleric acid;   3-methyl-3-hydroxybutyric acid;   Formula=C5H10O3;   HMB;   Hmb-d6;   InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7);   InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N;   SMILES=CC(C)(O)CC(O)=O;   beta-Hydroxyisovaleric acid;   beta-hydroxy-beta-methylbutyric acid
 xref: Beilstein:1743952;   CAS:625-08-1;   HMDB:HMDB0000754;   LIPID_MAPS_instance:LMFA01050396
 xref_mesh: MESH:C004961
 xref: PMID:12399279;   PMID:22770225;   PMID:9523856;   Reaxys:1743952;   Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82957


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3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions		 EXP beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]		 CTD PMID:24124592 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            eukaryotic metabolite 19380
              plant metabolite 17988
                isovaleric acid 1717
                  3-hydroxyisovaleric acid 5
                    3-hydroxyisovaleryl-CoA 0
                    3-hydroxyisovalerylcarnitine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      monocarboxylic acid 18007
                                        fatty acid 16847
                                          short-chain fatty acid 15933
                                            fatty acid 4:0 8232
                                              butyric acid 6728
                                                methylbutyric acid 2486
                                                  isovaleric acid 1717
                                                    3-hydroxyisovaleric acid 5
                                                      3-hydroxyisovaleryl-CoA 0
                                                      3-hydroxyisovalerylcarnitine 0
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