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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cimetidine
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Accession:CHEBI:3699 term browser browse the term
Definition:A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Synonyms:exact_synonym: 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
 related_synonym: 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine;   2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine;   Cimetag;   Formula=C10H16N6S;   InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);   InChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N;   N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine;   N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine;   SMILES=CN\\C(NCCSCc1nc[nH]c1C)=N\\C#N;   Tagamet HB 200;   Ulcerfen;   cimetidina;   cimetidinum
 xref: CAS:51481-61-9;   DrugBank:DB00501;   Drug_Central:645;   HMDB:HMDB0014644;   KEGG:D00295;   LINCS:LSM-2404
 xref_mesh: MESH:D002927
 xref: PMID:11910267;   PMID:15637527;   PMID:7229121;   Patent:BE804144;   Patent:US3950333;   Reaxys:6516325;   VSDB:1892;   Wikipedia:Cimetidine


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cimetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions		 ISO ABCG2 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]		 CTD PMID:15365089 PMID:15722455 PMID:26907376 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] CTD PMID:23220590 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA] CTD PMID:20956498 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions		 ISO Cimetidine affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein		 CTD PMID:22733800 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde] CTD PMID:23220590 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde] CTD PMID:23220590 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases activity ISO Cimetidine results in increased activity of APAF1 protein CTD PMID:17273750 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO
EXP		 Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein]
Cimetidine results in decreased expression of AR protein		 CTD PMID:6835285 PMID:26021711 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Cimetidine results in increased expression of BAX protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]		 CTD PMID:20127008 PMID:27983966 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Cimetidine results in decreased expression of BCL2 protein
Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]		 CTD PMID:20127008 PMID:27983966 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 ISO Cimetidine results in increased activity of CASP1 protein
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]		 CTD PMID:16723495 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein] CTD PMID:27983966 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 ISO
EXP		 Cimetidine results in increased activity of CASP3 protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
Cimetidine results in increased expression of CASP3 protein		 CTD PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Cimetidine results in increased activity of CASP7 protein CTD PMID:17273750 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Cimetidine results in increased activity of CASP8 protein CTD PMID:17273750 PMID:20127008 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Cimetidine results in increased activity of CASP9 protein CTD PMID:17273750 PMID:20127008 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd14 CD14 molecule decreases expression ISO Cimetidine results in decreased expression of CD14 protein CTD PMID:11556524 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3] CTD PMID:22525860 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctsd cathepsin D decreases activity EXP Cimetidine results in decreased activity of CTSD protein CTD PMID:12903910 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsl cathepsin L decreases activity EXP Cimetidine results in decreased activity of CTSL protein CTD PMID:12903910 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity		 ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]
Cimetidine results in decreased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein
Cimetidine results in decreased activity of CYP1A1 protein		 CTD PMID:11856816 PMID:22733800 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein] CTD PMID:7946932 PMID:19909766 PMID:31863871 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions
decreases activity		 ISO Cimetidine results in decreased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein
Cimetidine results in decreased activity of CYP2B6 protein		 CTD PMID:22733800 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine] CTD PMID:19961160 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions		 ISO
EXP		 Cimetidine results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]		 CTD PMID:17651725 PMID:19909766 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions		 ISO Cimetidine results in decreased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein		 CTD PMID:22733800 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity		 ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
Cimetidine results in decreased expression of CYP3A4 protein		 CTD PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein] CTD PMID:27983966 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
[Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]		 CTD PMID:17295779 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Cimetidine affects the expression of FSHB protein CTD PMID:435711 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gast gastrin affects expression ISO Cimetidine affects the expression of GAST protein CTD PMID:12503773 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects expression
multiple interactions		 ISO Cimetidine affects the expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein		 CTD PMID:22733800 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein] CTD PMID:12806184 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:14569158 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
increases expression		 ISO
EXP		 [Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
Cimetidine results in decreased activity of HRH2 protein
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
Cimetidine results in increased expression of HRH2 protein		 CTD PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:27983966 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of ICAM1 protein CTD PMID:17189874 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein		 CTD PMID:10569698 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il16 interleukin 16 multiple interactions ISO Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression		 ISO CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]
HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]		 CTD PMID:16723495 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itga4 integrin subunit alpha 4 decreases expression ISO Cimetidine results in decreased expression of ITGA4 protein CTD PMID:11556524 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Cimetidine results in decreased expression of ITGAX protein CTD PMID:11556524 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Cimetidine results in decreased expression of LRP1 protein CTD PMID:11556524 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein CTD PMID:17273750 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression
multiple interactions		 ISO Cimetidine results in decreased expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein		 CTD PMID:22733800 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression
multiple interactions		 ISO Cimetidine results in decreased expression of NR1I3 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein		 CTD PMID:22733800 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] CTD PMID:11131300 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Prl prolactin affects expression ISO Cimetidine affects the expression of PRL protein CTD PMID:435711 PMID:9037573 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Cimetidine results in decreased expression of PROK1 protein CTD PMID:26021711 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]		 CTD PMID:12065299 PMID:12107048 PMID:24300194 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Selp selectin P decreases expression ISO Cimetidine results in decreased expression of SELP protein CTD PMID:17189874 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases uptake
multiple interactions		 EXP
ISO		 SLC22A1 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]		 CTD PMID:16006492 PMID:19357179 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
increases transport
decreases response to substance
increases uptake		 ISO
EXP		 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]
SLC22A2 protein results in increased transport of Cimetidine
SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine		 CTD PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 More... NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases transport		 ISO Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
SLC22A3 protein results in increased transport of Cimetidine		 CTD PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake		 ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine] CTD PMID:15496291 PMID:16006492 PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake
multiple interactions		 ISO SLC22A7 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]		 CTD PMID:12065749 PMID:16006492 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake
affects transport		 ISO
EXP		 Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]
SLC22A8 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]		 CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 affects transport
multiple interactions
decreases activity		 ISO SLC47A1 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine results in decreased activity of SLC47A1 protein		 CTD PMID:16928787 PMID:21599003 PMID:27871888 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium] CTD PMID:21599003 PMID:27871888 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein] CTD PMID:12806184 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]		 CTD PMID:9088875 PMID:11856816 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          analgesic 14769
            cimetidine 69
              cimetidine S-oxide 0
              cimetidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  heteroarene 17151
                                    monocyclic heteroarene 14980
                                      azole 14503
                                        diazole 10770
                                          imidazoles 10220
                                            cimetidine 69
                                              cimetidine S-oxide 0
                                              cimetidine hydrochloride 0
paths to the root