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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cilazapril
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Accession:CHEBI:3698 term browser browse the term
Definition:A pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure.
Synonyms:related_synonym: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid;   Cilazapril anhydrous;   Dynorm;   Inhibace;   Ro 34-2848;   Vascace;   Vascase;   cilazaprilum
 xref: CAS:88768-40-5;   DrugBank:DB01340;   HMDB:HMDB0015433
 xref_mesh: MESH:D017315
 xref: drugcentral:641;   kegg.drug:D07699;   pubmed:18297254;   pubmed:1836986;   pubmed:21760854;   pubmed:24383331;   pubmed:24754013;   pubmed:25272892;   pubmed:28334985;   pubmed:28445944;   pubmed:31531043;   wikipedia.en:Cilazapril
 chemrof_formula: C22H31N3O5
 chemrof_smiles: CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCCN2CCC[C@@H](C(=O)O)N2C1=O
 chemrof_inchikey: HHHKFGXWKKUNCY-FHWLQOOXSA-N
 chemrof_inchi: InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
 cyclic_relationship: has_functional_parent CHEBI:81005


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cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cilazapril results in increased expression of ADIPOQ protein CTD PMID:19789415 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] CTD PMID:15331931 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein CTD PMID:9640960 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
affects secretion 		ISO [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein 		CTD PMID:1457087 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Ren renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2425185 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:77,519,565...77,548,609
Ensembl chr11:77,519,529...77,548,606 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:15331931 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pro-agent 8265
          prodrug 7985
            cilazapril 10
              cilazapril monohydrate 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      ethyl ester 6137
                                        cilazapril 10
                                          cilazapril monohydrate 10
paths to the root