CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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ATF4
activating transcription factor 4
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of ATF4 protein]
CTD
PMID:37442268
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
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BAX
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium results in increased expression of BAX protein]
CTD
PMID:19135140
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147
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BCL2
BCL2 apoptosis regulator
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]
CTD
PMID:19135140
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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CASP3
caspase 3
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Selenium inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
CTD
PMID:17383151 PMID:19135140
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP9
caspase 9
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium results in increased activity of CASP9 protein]
CTD
PMID:19135140
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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CLDN1
claudin 1
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
CTD
PMID:37442268
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
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CXCL8
C-X-C motif chemokine ligand 8
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]
CTD
PMID:37442268
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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DDIT3
DNA damage inducible transcript 3
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of DDIT3 protein]
CTD
PMID:37442268
NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
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EIF2A
eukaryotic translation initiation factor 2A
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2A protein]
CTD
PMID:37442268
NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
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EIF2AK3
eukaryotic translation initiation factor 2 alpha kinase 3
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2AK3 protein]
CTD
PMID:37442268
NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
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GAPDH
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
EXP
Selenium inhibits the reaction [Paraquat results in decreased activity of GAPDH protein]
CTD
PMID:17055214
NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
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GPX1
glutathione peroxidase 1
increases activity
EXP
Selenium analog results in increased activity of GPX1 protein
CTD
PMID:37442268
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of HSPA5 protein]
CTD
PMID:37442268
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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IL10
interleukin 10
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in decreased expression of IL10 protein]
CTD
PMID:37442268
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
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IL6
interleukin 6
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]
CTD
PMID:37442268
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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ITPR1
inositol 1,4,5-trisphosphate receptor type 1
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased expression of ITPR1 protein]
CTD
PMID:37442268
NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912
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MAPK8
mitogen-activated protein kinase 8
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]
CTD
PMID:17383151
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
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MAPK9
mitogen-activated protein kinase 9
multiple interactions
EXP
Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]
CTD
PMID:17383151
NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
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OCLN
occludin
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]
CTD
PMID:37442268
NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
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SOD1
superoxide dismutase 1
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in increased activity of SOD1 protein]
CTD
PMID:37442268
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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TGFB1
transforming growth factor beta 1
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in decreased expression of TGFB1 protein]
CTD
PMID:37442268
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TJP1
tight junction protein 1
multiple interactions
EXP
Selenium analog inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein]
CTD
PMID:37442268
NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
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TXNRD1
thioredoxin reductase 1
increases expression multiple interactions increases activity
EXP
Selenium results in increased expression of TXNRD1 mRNA Selenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein] Selenium analog results in increased activity of TXNRD1 protein; Selenium results in increased activity of TXNRD1 protein
CTD
PMID:16908641 PMID:17055214 PMID:37442268
NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219
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