elemental selenium - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	elemental selenium	go back to main search page
Accession:	CHEBI:36904	browse the term
Synonyms:	xref:	CAS:7782-49-2
	xref_mesh:	MESH:D012643

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Genes (1607)

elemental selenium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression
multiple interactions

Selenium results in increased expression of A2M mRNA
Selenium inhibits the reaction [T-2 Toxin results in decreased expression of A2M mRNA]; Selenium promotes the reaction [T-2 Toxin results in decreased expression of A2M protein]

PMID:18997278 PMID:21144892

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

angio-associated, migratory cell protein

increases expression

Selenium results in increased expression of AAMP mRNA

NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547

G

aminoadipate-semialdehyde synthase

decreases expression
multiple interactions

Selenium results in decreased expression of AASS mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of AASS mRNA

NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136

G

apoptosis antagonizing transcription factor

increases expression

Selenium results in increased expression of AATF mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

ATP binding cassette subfamily A member 7

increases expression

Selenium results in increased expression of ABCA7 mRNA

NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425

G

ATP binding cassette subfamily C member 2

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of ABCC2 mRNA
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC2 mRNA]

PMID:11444866 PMID:36464106

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily F member 3

increases expression

Selenium results in increased expression of ABCF3 mRNA

NCBI chr11:80,340,476...80,352,211
Ensembl chr11:80,339,977...80,352,211

G

ATP binding cassette subfamily G member 2

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCG2 mRNA]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of ABCG5 mRNA]

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

abhydrolase domain containing 17A, depalmitoylase

increases expression

Selenium results in increased expression of ABHD17A mRNA

NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

Selenium results in increased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

ABR activator of RhoGEF and GTPase

increases expression

Selenium results in increased expression of ABR mRNA

NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505

G

acetyl-CoA acyltransferase 2

increases expression

Selenium results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acyl-CoA dehydrogenase short chain

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of ACADS mRNA
Selenium results in increased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acetylcholinesterase

multiple interactions

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]

PMID:20688495 PMID:37415728

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

apoptotic chromatin condensation inducer 1

increases expression

Selenium results in increased expression of ACIN1 mRNA

NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001

G

aconitase 2

increases expression

Selenium results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 2

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of ACOT2 mRNA
Selenium results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acid phosphatase 1

decreases expression

Selenium results in decreased expression of ACP1 mRNA

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

[2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] inhibits the reaction [Aflatoxin B1 results in increased expression of ACSL4 protein]; [2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] which results in decreased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

actin, beta

increases expression

Selenium results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

increases expression

Selenium results in increased expression of ACTG1 mRNA

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actinin, alpha 1

increases expression

Selenium results in increased expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

increases expression

Selenium results in increased expression of ACTN4 mRNA

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

actin related protein 1A

increases expression

Selenium results in increased expression of ACTR1A mRNA

NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495

G

actin related protein 1B

increases expression

Selenium results in increased expression of ACTR1B mRNA

NCBI chr 9:38,928,819...38,938,483
Ensembl chr 9:38,929,912...38,938,507

G

aminoacylase 1

increases expression

Selenium results in increased expression of ACY1 mRNA

NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

decreases expression

Selenium results in decreased expression of ADAMTS5 mRNA

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

ArfGAP with dual PH domains 1

increases expression

Selenium results in increased expression of ADAP1 mRNA

NCBI chr12:15,323,913...15,376,110
Ensembl chr12:15,324,209...15,380,831

G

adenylate cyclase 2

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNA
Selenium results in decreased expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase 6

increases expression

Selenium results in increased expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adducin 1

increases expression

Selenium results in increased expression of ADD1 mRNA

NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182

G

adducin 3

decreases expression

Selenium results in decreased expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor B1

increases expression

Selenium results in increased expression of ADGRB1 mRNA

NCBI chr 7:106,404,827...106,476,902
Ensembl chr 7:106,404,958...106,476,902

G

adipose secreted signaling protein

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of ADISSP mRNA

NCBI chr 3:118,364,730...118,378,881
Ensembl chr 3:118,362,363...118,378,838

G

adenosine A2a receptor

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 2C

increases expression

Selenium results in increased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

Selenium results in increased expression of ADRM1 mRNA

NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195

G

AE binding protein 2

decreases methylation

Selenium results in decreased methylation of AEBP2 gene

NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100

G

1-acylglycerol-3-phosphate O-acyltransferase 2

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of AGPAT2 mRNA
Selenium results in increased expression of AGPAT2 mRNA

NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371

G

agrin

increases expression

Selenium results in increased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of AIMP1 mRNA
Selenium results in decreased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

aryl-hydrocarbon receptor-interacting protein

increases expression

Selenium results in increased expression of AIP mRNA

NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122

G

adenylate kinase 1

increases expression

Selenium results in increased expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

adenylate kinase 2

increases expression

Selenium results in increased expression of AK2 mRNA

NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632

G

adenylate kinase 3

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 13

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
increases expression
increases phosphorylation

[Selenium results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein]; Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
Selenium results in increased expression of AKT1 mRNA
Selenium inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]
Selenium results in increased phosphorylation of AKT1 protein
Selenium inhibits the reaction [arsenite results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Selenium inhibits the reaction [Potassium Iodide results in increased phosphorylation of AKT1 protein]

PMID:17339365 PMID:17997286 PMID:19244175 PMID:29324385 PMID:38013145

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

Selenium inhibits the reaction [Arsenic results in decreased activity of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

5'-aminolevulinate synthase 1

increases expression

Selenium results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

multiple interactions

[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]

PMID:24485406 PMID:37676925

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activated leukocyte cell adhesion molecule

decreases expression

Selenium results in decreased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 1 family, member B1

increases expression

Selenium deficiency results in increased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 1 family, member L1

affects expression

Selenium affects the expression of ALDH1L1 protein

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 4 family, member A1

increases expression

Selenium results in increased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

aldolase, fructose-bisphosphate A

increases expression

Selenium results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

ALG3, alpha-1,3- mannosyltransferase

increases expression

Selenium results in increased expression of ALG3 mRNA

NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912

G

ALG9, alpha-1,2-mannosyltransferase

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of ALG9 mRNA

NCBI chr 8:51,117,057...51,188,790
Ensembl chr 8:51,119,365...51,182,261

G

arachidonate 15-lipoxygenase

increases expression
multiple interactions

Selenium deficiency results in increased expression of ALOX15 mRNA
Selenomethionine inhibits the reaction [Selenium deficiency results in increased expression of ALOX15 protein]; Sodium Selenite inhibits the reaction [Selenium deficiency results in increased expression of ALOX15 protein]

PMID:11444866 PMID:34970773

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

arachidonate 5-lipoxygenase

multiple interactions

[Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 mRNA; [Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 protein

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

ALS2 C-terminal like

increases expression

Selenium results in increased expression of ALS2CL mRNA

NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419

G

adenosine monophosphate deaminase 3

decreases expression

Selenium results in decreased expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

anaphase promoting complex subunit 15

increases expression

Selenium results in increased expression of ANAPC15 mRNA

NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145

G

anaphase promoting complex subunit 2

increases expression

Selenium results in increased expression of ANAPC2 mRNA

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

angiopoietin 1

decreases expression

Selenium results in decreased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

ankyrin 3

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat family A member 2

decreases expression

Selenium results in decreased expression of ANKRA2 mRNA

NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730

G

acidic nuclear phosphoprotein 32 family member B

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of ANP32B mRNA

NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717

G

alanyl aminopeptidase, membrane

increases expression

Selenium results in increased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

aldehyde oxidase 1

multiple interactions
decreases expression

Selenium deficiency results in decreased expression of and results in decreased activity of AOX1 protein
Selenium deficiency results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit beta 1

increases expression

Selenium results in increased expression of AP1B1 mRNA

NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778

G

adaptor related protein complex 1 subunit mu 2

increases expression

Selenium results in increased expression of AP1M2 mRNA

NCBI chr 8:19,838,579...19,856,560
Ensembl chr 8:19,838,580...19,856,482

G

adaptor related protein complex 2 subunit alpha 2

increases expression

Selenium results in increased expression of AP2A2 mRNA

NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603

G

adaptor related protein complex 2 subunit mu 1

increases expression

Selenium results in increased expression of AP2M1 mRNA

NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140

G

adaptor related protein complex 2 subunit sigma 1

increases expression

Selenium results in increased expression of AP2S1 mRNA

NCBI chr 1:77,417,496...77,428,903
Ensembl chr 1:77,417,477...77,428,905

G

APC regulator of WNT signaling pathway

decreases expression

Selenium results in decreased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

acylaminoacyl-peptide hydrolase

increases expression

Selenium results in increased expression of APEH mRNA

NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933

G

amyloid beta precursor like protein 2

increases expression

Selenium results in increased expression of APLP2 mRNA

NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855

G

apolipoprotein B

multiple interactions
decreases expression

Selenium inhibits the reaction [Cholesterol results in increased expression of APOB protein]
Selenium results in decreased expression of APOB protein

PMID:16271152 PMID:16581047

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

increases expression
affects expression

Selenium results in increased expression of APOE mRNA
Selenium affects the expression of APOE protein

PMID:17996733 PMID:19244175

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

decreases expression

Selenium results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

amyloid beta precursor protein binding protein 2

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of APPBP2 mRNA

NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835

G

aquaporin 3 (Gill blood group)

increases expression
multiple interactions

Selenium results in increased expression of AQP3 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

androgen receptor

multiple interactions
decreases expression
decreases localization

Selenium results in decreased expression of and results in decreased activity of AR protein
Selenium results in decreased expression of AR mRNA
Selenium results in decreased localization of AR protein

PMID:14729601 PMID:16648561

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

A-Raf proto-oncogene, serine/threonine kinase

increases expression
multiple interactions

Selenium results in increased expression of ARAF mRNA
[Selenium co-treated with Vitamin E] results in increased expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

ARF GTPase 5

increases expression

Selenium results in increased expression of ARF5 mRNA

NCBI chr 4:57,038,521...57,041,447
Ensembl chr 4:57,038,521...57,041,441

G

ARF GTPase activating protein 2

increases expression

Selenium results in increased expression of ARFGAP2 mRNA

NCBI chr 3:77,236,305...77,248,445
Ensembl chr 3:77,236,322...77,248,455

G

ARF interacting protein 2

increases expression

Selenium results in increased expression of ARFIP2 mRNA

NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336

G

ARF related protein 1

increases expression

Selenium results in increased expression of ARFRP1 mRNA

NCBI chr 3:168,466,351...168,473,960
Ensembl chr 3:168,466,496...168,473,914

G

arginase 1

multiple interactions

2-chloro-5-nitrobenzanilide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; [Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein; [Selenium co-treated with IL4 protein] results in increased expression of ARG1 mRNA; leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; rosiglitazone promotes the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

arginase 2

decreases expression

Selenium results in decreased expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho GDP dissociation inhibitor alpha

increases expression

Selenium results in increased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

Selenium results in decreased expression of ARIH1 mRNA

NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245

G

ARF like GTPase 5A

decreases expression

Selenium results in decreased expression of ARL5A mRNA

NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211

G

ARF like GTPase 6 interacting protein 4

increases expression

Selenium results in increased expression of ARL6IP4 mRNA

NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799

G

actin related protein 2/3 complex, subunit 1A

increases expression

Selenium results in increased expression of ARPC1A mRNA

NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330

G

actin related protein 2/3 complex, subunit 1B

increases expression

Selenium results in increased expression of ARPC1B mRNA

NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747

G

actin related protein 2/3 complex, subunit 4

increases expression

Selenium results in increased expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

arsenite methyltransferase

multiple interactions

Selenium inhibits the reaction [AS3MT protein results in increased methylation of Arsenic]

NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

increases expression

Selenium results in increased expression of ASAP3 mRNA

NCBI chr 5:148,433,382...148,476,027
Ensembl chr 5:148,433,494...148,474,073

G

ankyrin repeat and SOCS box-containing 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of ASB1 mRNA
Selenium results in increased expression of ASB1 mRNA

NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376

G

activating signal cointegrator 1 complex subunit 2

increases expression

Selenium results in increased expression of ASCC2 mRNA

NCBI chr14:79,503,449...79,547,801
Ensembl chr14:79,503,517...79,545,494

G

argininosuccinate lyase

increases expression

Selenium results in increased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

acetylserotonin O-methyltransferase-like

increases expression

Selenium results in increased expression of ASMTL mRNA

NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080

G

argininosuccinate synthase 1

increases expression

Selenium results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ASXL transcriptional regulator 1

decreases expression

Selenium results in decreased expression of ASXL1 mRNA

NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538

G

ASXL transcriptional regulator 2

decreases expression

Selenium results in decreased expression of ASXL2 mRNA

NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477

G

activating transcription factor 4

increases expression

Selenium results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of ATF5 mRNA
Selenium results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

autophagy related 12

decreases expression

Selenium results in decreased expression of ATG12 mRNA

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 13

increases expression

Selenium results in increased expression of ATG13 mRNA

NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043

G

autophagy related 14

decreases expression

Selenium results in decreased expression of ATG14 mRNA

NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113

G

autophagy related 9A

increases expression

Selenium results in increased expression of ATG9A mRNA

NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986

G

ATM interactor

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of ATMIN mRNA
Selenium results in decreased expression of ATMIN mRNA

NCBI chr19:44,996,506...45,013,606
Ensembl chr19:44,996,356...45,013,605

G

ATPase phospholipid transporting 10D (putative)

decreases expression

Selenium results in decreased expression of ATP10D mRNA

NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564

G

ATPase plasma membrane Ca2+ transporting 4

increases expression

Selenium results in increased expression of ATP2B4 mRNA

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATPase secretory pathway Ca2+ transporting 1

decreases expression

Selenium results in decreased expression of ATP2C1 mRNA

NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006

G

ATP synthase membrane subunit e

decreases expression

Selenium results in decreased expression of ATP5ME mRNA

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase peripheral stalk subunit d

decreases expression

Selenium results in decreased expression of ATP5PD mRNA

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase peripheral stalk subunit F6

decreases expression

Selenium results in decreased expression of ATP5PF mRNA

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

G

ATPase H+ transporting accessory protein 1

increases expression

Selenium results in increased expression of ATP6AP1 mRNA

NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034

G

ATPase H+ transporting V0 subunit D1

increases expression

Selenium results in increased expression of ATP6V0D1 mRNA

NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450

G

ATPase H+ transporting V0 subunit e1

decreases expression

Selenium results in decreased expression of ATP6V0E mRNA

NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434

G

ATPase H+ transporting V1 subunit C1

decreases expression

Selenium results in decreased expression of ATP6V1C1 mRNA

NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278

G

ATRX, chromatin remodeler

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of ATRX mRNA
Selenium results in decreased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

ataxin 1

decreases expression

Selenium results in decreased expression of ATXN1 mRNA

NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360

G

ataxin 7

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of ATXN7 mRNA
Selenium results in decreased expression of ATXN7 mRNA

NCBI chr15:11,117,360...11,262,818
Ensembl chr15:11,118,886...11,263,106

G

AVL9 cell migration associated

decreases expression

Selenium results in decreased expression of AVL9 mRNA

NCBI chr 4:85,961,493...86,008,347
Ensembl chr 4:85,961,635...86,008,791

G

Axl receptor tyrosine kinase

decreases expression

Selenium results in decreased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

beta-1,3-glucuronyltransferase 3

increases expression

Selenium results in increased expression of B3GAT3 mRNA

NCBI chr 1:205,817,374...205,823,928
Ensembl chr 1:205,817,378...205,837,807

G

BAG cochaperone 1

increases expression

Selenium results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BAG cochaperone 6

increases expression

Selenium results in increased expression of BAG6 mRNA

NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657

G

BRCA1 associated deubiquitinase 1

increases expression

Selenium results in increased expression of BAP1 mRNA

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

BRCA1 associated RING domain 1

decreases expression

Selenium results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

basic leucine zipper ATF-like transcription factor

increases expression

Selenium results in increased expression of BATF mRNA

NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions

Selenium results in decreased expression of BAX protein
[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; Selenium analog inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; Selenium inhibits the reaction [T-2 Toxin results in increased expression of BAX mRNA]
Selenium inhibits the reaction [arsenite results in increased expression of BAX protein]

PMID:16307838 PMID:17997286 PMID:27920530 PMID:29324385

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

increases expression

Selenium results in increased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BBX high mobility group box domain containing

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA
Selenium results in decreased expression of BBX mRNA

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

G

BCL11 transcription factor A

decreases expression

Selenium results in decreased expression of BCL11A mRNA

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Selenium results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased expression of BCL2 mRNA]; Selenium analog inhibits the reaction [Diazinon results in decreased expression of BCL2 mRNA]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]

PMID:17523932 PMID:27920530 PMID:34612572

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions

Selenium results in increased expression of BCL2L1 mRNA
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of BCL2L1 mRNA

PMID:11444866 PMID:19244175

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

multiple interactions
increases expression

BCL2L11 protein affects the susceptibility to [Doxorubicin co-treated with Selenium]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with Selenium] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein]
Selenium results in increased expression of BCL2L11 protein

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

increases expression

Selenium results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BAF chromatin remodeling complex subunit BCL7B

increases expression

Selenium results in increased expression of BCL7B mRNA

NCBI chr12:21,496,860...21,510,079
Ensembl chr12:21,496,856...21,510,202

G

BCL2-associated transcription factor 1

decreases expression
multiple interactions

Selenium results in decreased expression of BCLAF1 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of BCLAF1 mRNA

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

Selenium results in decreased expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

G

brain-derived neurotrophic factor

increases expression
multiple interactions

Selenium results in increased expression of BDNF protein
Selenium inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

Selenium deficiency inhibits the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]; Selenium inhibits the reaction [Acrylamide results in increased expression of BECN1 protein]

PMID:30629952 PMID:37987225

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BICD cargo adaptor 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of BICD1 mRNA
Selenium results in decreased expression of BICD1 mRNA

NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434

G

BICD family like cargo adaptor 1

increases expression

Selenium results in increased expression of BICDL1 mRNA

NCBI chr12:40,878,190...41,001,152
Ensembl chr12:40,876,884...40,966,130

G

BRD4 interacting chromatin remodeling complex associated protein

increases expression

Selenium results in increased expression of BICRA mRNA

NCBI chr 1:76,661,897...76,736,146
Ensembl chr 1:76,661,897...76,737,157

G

BH3 interacting domain death agonist

increases cleavage

Selenium results in increased cleavage of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

increases expression

Selenium results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 2

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

affects response to substance
multiple interactions

BIRC5 protein affects the susceptibility to Selenium
[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased expression of BIRC5 mRNA]; Selenium analog inhibits the reaction [Diazinon results in decreased expression of BIRC5 mRNA]

PMID:17876054 PMID:27920530

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basophilic leukemia expressed protein BLES03

increases expression

Selenium results in increased expression of C11ORF68 mRNA

NCBI chr 1:202,734,555...202,736,809
Ensembl chr 1:202,734,555...202,736,804

G

bridge-like lipid transfer protein family member 2

increases expression

Selenium results in increased expression of BLTP2 mRNA

NCBI chr10:63,155,999...63,185,213
Ensembl chr10:63,156,044...63,191,141

G

bridge-like lipid transfer protein family member 3B

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of BLTP3B mRNA
Selenium results in decreased expression of BLTP3B mRNA

NCBI chr 7:24,181,635...24,261,720
Ensembl chr 7:24,181,644...24,261,720

G

biliverdin reductase B

increases expression

Selenium results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bromodomain PHD finger transcription factor

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of BPTF mRNA
Selenium results in decreased expression of BPTF mRNA

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

bromodomain containing 2

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNA
Selenium results in increased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

BRF2 general transcription factor 3B subunit

increases expression

Selenium results in increased expression of BRF2 mRNA

NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059

G

BRMS1, transcriptional repressor and anoikis regulator

increases expression

Selenium results in increased expression of BRMS1 mRNA

NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028

G

BSCL2 lipid droplet biogenesis associated, seipin

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of BSCL2 mRNA
Selenium results in increased expression of BSCL2 mRNA

NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421

G

bone marrow stromal cell antigen 2

increases expression

Selenium results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

bystin-like

increases expression

Selenium results in increased expression of BYSL mRNA

NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339

G

similar to human chromosome 7 open reading frame 25

decreases expression

Selenium results in decreased expression of C7ORF25 mRNA

NCBI chr17:50,543,231...50,549,880
Ensembl chr17:50,542,858...50,549,976

G

complement C1q B chain

increases expression

Selenium results in increased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

C2 calcium-dependent domain containing 5

decreases expression

Selenium results in decreased expression of C2CD5 mRNA

NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558

G

similar to human chromosome 1 open reading frame 54

decreases expression

Selenium results in decreased expression of C1ORF54 mRNA

NCBI chr 2:183,424,989...183,434,713
Ensembl chr 2:183,424,984...183,435,089

G

similar to human chromosome 2 open reading frame 42

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of C2ORF42 mRNA
Selenium results in decreased expression of C2ORF42 mRNA

NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936

G

similar to human chromosome 1 open reading frame 50

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of C1ORF50 mRNA
Selenium results in decreased expression of C1ORF50 mRNA

NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762

G

similar to human chromosome 14 open reading frame 132

decreases expression

Selenium results in decreased expression of C14ORF132 mRNA

NCBI chr 6:124,365,466...124,398,449

G

calcineurin binding protein 1

increases expression

Selenium results in increased expression of CABIN1 mRNA

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcium binding and coiled coil domain 1

increases expression

Selenium results in increased expression of CALCOCO1 mRNA

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

caldesmon 1

decreases expression

Selenium results in decreased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calcium homeostasis modulator family member 2

increases expression

Selenium results in increased expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calmodulin 3

increases expression

Selenium results in increased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calreticulin

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CALR mRNA
Selenium results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNA
Selenium results in increased expression of CALU mRNA

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

Selenium results in increased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

cyclase associated actin cytoskeleton regulatory protein 2

decreases expression

Selenium results in decreased expression of CAP2 mRNA

NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373

G

capping actin protein, gelsolin like

increases expression

Selenium results in increased expression of CAPG mRNA

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calpain 1

increases expression

Selenium results in increased expression of CAPN1 mRNA

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 7

decreases expression

Selenium results in decreased expression of CAPN7 mRNA

NCBI chr16:6,545,630...6,581,908
Ensembl chr16:6,545,731...6,581,905

G

calpain, small subunit 1

increases expression

Selenium results in increased expression of CAPNS1 mRNA

NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795

G

capping actin protein of muscle Z-line subunit beta

increases expression

Selenium results in increased expression of CAPZB mRNA

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

carbonic anhydrase 3

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

CASC3 exon junction complex subunit

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of MLN51 mRNA

NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966

G

caspase 12

multiple interactions

Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

decreases activity
increases activity
multiple interactions

Selenium results in decreased activity of CASP3 protein
Selenium results in increased activity of CASP3 protein
[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; Selenium deficiency promotes the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Selenium inhibits the reaction [arsenite results in increased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CASP3 mRNA]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]

PMID:15318939 PMID:17997286 PMID:21628957 PMID:27920530 PMID:29324385 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 8

multiple interactions
increases activity
decreases expression

[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]; [Doxorubicin co-treated with Selenium] promotes the reaction [FAS protein binds to CASP8 protein]; Selenium analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA]
Selenium results in increased activity of CASP8 protein
Selenium results in decreased expression of CASP8 mRNA

PMID:12432279 PMID:17970047 PMID:19244175 PMID:27920530

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
decreases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; [Doxorubicin co-treated with Selenium] results in increased cleavage of and results in increased activity of CASP9 protein; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with Selenium] results in increased cleavage of and results in increased activity of CASP9 protein]; Selenium analog inhibits the reaction [Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP9 mRNA]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; Selenium inhibits the reaction [arsenite results in increased expression of CASP9 mRNA]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
Selenium results in decreased activity of CASP9 protein

PMID:17339365 PMID:17997286 PMID:21628957 PMID:27920530 PMID:29324385 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases expression
increases activity
decreases expression

Arsenic promotes the reaction [Selenium results in increased expression of CAT protein]; Fluorides promotes the reaction [Selenium results in increased activity of CAT protein]; Selenium inhibits the reaction [Fluorides results in decreased activity of CAT protein]
[[Sodium Selenite results in increased abundance of Selenium] which co-treated with Ascorbic Acid] inhibits the reaction [barium chloride results in decreased activity of CAT protein]; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [barium chloride results in decreased activity of CAT protein]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Selenium affects the reaction [Clofibrate results in increased activity of CAT protein]; Selenium affects the reaction [Mercury results in decreased activity of CAT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Selenium inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Selenium inhibits the reaction [chromium hexavalent ion results in decreased activity of CAT protein]; Selenium inhibits the reaction [chromium hexavalent ion results in increased activity of CAT protein]; Selenium inhibits the reaction [Chromium results in increased activity of CAT protein]; Selenium inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]; Selenium inhibits the reaction [Enrofloxacin results in decreased activity of CAT protein]; Selenium inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Selenium inhibits the reaction [nickel sulfate results in increased activity of CAT protein]; Selenium inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Selenium inhibits the reaction [Potassium Dichromate results in increased activity of CAT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]]
Selenium deficiency results in decreased expression of CAT mRNA

PMID:3456598 PMID:8250967 PMID:11260395 PMID:17512462 PMID:19652462 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolae associated protein 1

increases expression

Selenium results in increased expression of CAVIN1 mRNA

NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120

G

Cbl proto-oncogene B

decreases expression

Selenium results in decreased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

chromobox 5

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CBX5 mRNA
Selenium results in decreased expression of CBX5 mRNA

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

chromobox 7

increases expression

Selenium results in increased expression of CBX7 mRNA

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

coiled-coil domain containing 85B

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DIPA mRNA
Selenium results in increased expression of DIPA mRNA

NCBI chr 1:202,763,645...202,764,660
Ensembl chr 1:202,763,631...202,764,703

G

coiled-coil alpha-helical rod protein 1

increases expression

Selenium results in increased expression of CCHCR1 mRNA

NCBI chr20:3,205,675...3,218,437
Ensembl chr20:3,205,676...3,218,308

G

C-C motif chemokine ligand 2

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CCL2 mRNA; Selenium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Selenium inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL2 mRNA]

PMID:16143069 PMID:21481475

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin B1

decreases expression

Selenium deficiency results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin C

decreases expression

Selenium deficiency results in decreased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

increases expression
multiple interactions

Selenium results in increased expression of CCND1 mRNA
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CCND1 mRNA

PMID:11444866 PMID:19244175

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

Selenium deficiency results in decreased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cell cycle progression 1

decreases expression

Selenium results in decreased expression of CPR8 mRNA

NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430

G

C-C motif chemokine receptor 3

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of CCR3 mRNA

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

coiled-coil serine-rich protein 2

decreases expression

Selenium results in decreased expression of CCSER2 mRNA

NCBI chr16:12,613,103...12,725,764
Ensembl chr16:12,613,103...12,725,738

G

CD14 molecule

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

Cd2 (cytoplasmic tail) binding protein 2

increases expression

Selenium results in increased expression of CD2BP2 mRNA

NCBI chr 1:181,809,399...181,815,269
Ensembl chr 1:181,809,406...181,813,448

G

CD44 molecule

multiple interactions
increases expression

Selenium inhibits the reaction [T-2 Toxin results in decreased expression of CD44 protein]
Selenium results in increased expression of CD44 mRNA; Selenium results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD74 molecule

increases expression

Selenium results in increased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD99 molecule (Xg blood group)

increases expression

Selenium results in increased expression of CD99 mRNA

NCBI chr20:54,418,239...54,422,882

G

cell division cycle 14B

decreases expression

Selenium results in decreased expression of CDC14B mRNA

NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235

G

cell division cycle 16

decreases expression

Selenium results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 23

decreases expression

Selenium results in decreased expression of CDC23 mRNA

NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163

G

CDC42 binding protein kinase alpha

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA
Selenium results in decreased expression of CDC42BPA mRNA

NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732

G

CDC42 effector protein 4

increases expression

Selenium results in increased expression of CDC42EP4 mRNA

NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695

G

cell division cycle 73

decreases expression

Selenium results in decreased expression of CDC73 mRNA

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cadherin 11

decreases expression

Selenium results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cadherin 3

increases expression

Selenium results in increased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cyclin-dependent kinase 1

decreases expression

Selenium deficiency results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

increases expression
multiple interactions

Selenium results in increased expression of CDK10 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin dependent kinase 2

decreases expression

Selenium deficiency results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 2 associated protein 2

increases expression

Selenium results in increased expression of CDK2AP2 mRNA

NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137

G

cyclin-dependent kinase 4

decreases expression
increases expression

Selenium deficiency results in decreased expression of CDK4 mRNA
Selenium results in increased expression of CDK4 mRNA

PMID:11925459 PMID:19244175

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1C

decreases expression

Selenium results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

CDP-diacylglycerol synthase 1

decreases expression

Selenium results in decreased expression of CDS1 mRNA

NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681

G

CCAAT/enhancer binding protein alpha

increases expression

Selenium results in increased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

carboxyl ester lipase

increases expression

Selenium results in increased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

CUGBP, Elav-like family member 2

decreases expression

Selenium results in decreased expression of CELF2 mRNA

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

centrosomal protein 170

decreases expression

Selenium results in decreased expression of CEP170 mRNA

NCBI chr13:88,669,672...88,754,011
Ensembl chr13:88,670,358...88,732,226

G

centrosomal protein 290

decreases expression

Selenium results in decreased expression of CEP290 mRNA

NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392

G

centrosomal protein 350

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of CEP350 mRNA
Selenium results in decreased expression of CEP350 mRNA

NCBI chr13:68,023,327...68,164,478
Ensembl chr13:68,026,891...68,165,214

G

centrosomal protein 57

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CEP57 mRNA
Selenium results in decreased expression of CEP57 mRNA

NCBI chr 8:10,669,588...10,689,257
Ensembl chr 8:10,669,590...10,689,249

G

ceramide transporter 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of CERT1 mRNA
Selenium results in decreased expression of CERT1 mRNA

NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074

G

carboxylesterase 1D

increases expression

Selenium results in increased expression of CES1 mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

complement factor H

decreases expression

Selenium results in decreased expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]; Selenium analog promotes the reaction [Diazinon results in increased expression of CFLAR mRNA]

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

chromodomain helicase DNA binding protein 1

decreases expression
multiple interactions

Selenium results in decreased expression of CHD1 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of CHD1 mRNA

NCBI chr 1:56,661,743...56,729,119
Ensembl chr 1:56,664,054...56,728,125

G

chromodomain helicase DNA binding protein 3

increases expression

Selenium results in increased expression of CHD3 mRNA

NCBI chr10:54,063,629...54,090,030
Ensembl chr10:54,063,629...54,090,047

G

chromodomain helicase DNA binding protein 4

increases expression

Selenium results in increased expression of CHD4 mRNA

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

chromodomain helicase DNA binding protein 9

decreases expression

Selenium results in decreased expression of CHD9 mRNA

NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556

G

choline kinase alpha

increases expression

Selenium results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

charged multivesicular body protein 1A

increases expression

Selenium results in increased expression of CHMP1A mRNA

NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436

G

charged multivesicular body protein 2A

increases expression

Selenium results in increased expression of CHMP2A mRNA

NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452

G

chimerin 2

increases expression

Selenium results in increased expression of CHN2 mRNA

NCBI chr 4:83,148,616...83,407,711
Ensembl chr 4:83,147,983...83,407,709

G

cysteine and histidine rich domain containing 1

decreases expression

Selenium results in decreased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

chondroitin polymerizing factor

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CHPF mRNA
Selenium results in increased expression of CHPF mRNA

NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878

G

cholinergic receptor nicotinic alpha 4 subunit

increases expression

Selenium results in increased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic epsilon subunit

increases expression

Selenium results in increased expression of CHRNE mRNA

NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530

G

carbohydrate sulfotransferase 3

increases expression

Selenium results in increased expression of CHST3 mRNA

NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807

G

carbohydrate sulfotransferase 5

increases expression

Selenium results in increased expression of CHST6 mRNA

NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064

G

CDKN1A interacting zinc finger protein 1

increases expression

Selenium results in increased expression of CIZ1 mRNA

NCBI chr 3:15,658,479...15,673,762
Ensembl chr 3:15,658,539...15,673,762

G

cytoskeleton associated protein 2

decreases expression

Selenium results in decreased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase B

increases expression

Selenium results in increased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Selenium results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

chloride channel CLIC-like 1

decreases expression

Selenium results in decreased expression of CLCC1 mRNA

NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913

G

chloride voltage-gated channel 3

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of CLCN3 mRNA
Selenium results in decreased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

claudin 4

increases expression

Selenium results in increased expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 5

multiple interactions

[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; Selenium results in increased expression of and results in increased localization of CLDN5 protein

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

C-type lectin domain family 3, member B

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of TNA mRNA
Selenium results in increased expression of TNA mRNA

NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835

G

CLN3 lysosomal/endosomal transmembrane protein, battenin

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of CLN3 mRNA
Selenium results in increased expression of CLN3 mRNA

NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434

G

CLPTM1 regulator of GABA type A receptor forward trafficking

increases expression

Selenium results in increased expression of CLPTM1 mRNA

NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092

G

clathrin, light chain B

increases expression

Selenium results in increased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

clusterin

increases expression

Selenium results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

C-x(9)-C motif containing 2

decreases expression

Selenium results in decreased expression of CMC2 mRNA

NCBI chr19:44,943,283...44,971,930
Ensembl chr19:44,943,285...44,971,983

G

cornichon family member 1

decreases expression

Selenium results in decreased expression of CNIH1 mRNA

NCBI chr15:20,037,885...20,049,857
Ensembl chr15:20,037,885...20,049,761

G

cornichon family member 4

decreases expression

Selenium results in decreased expression of CNIH4 mRNA

NCBI chr13:92,910,315...92,926,428
Ensembl chr13:92,910,315...92,927,853

G

calponin 2

increases expression

Selenium results in increased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

calponin 3

increases expression

Selenium results in increased expression of CNN3 mRNA

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

CCR4-NOT transcription complex, subunit 8

decreases expression

Selenium results in decreased expression of CNOT8 mRNA

NCBI chr10:42,281,614...42,294,740
Ensembl chr10:42,281,722...42,294,730

G

canopy FGF signaling regulator 2

decreases expression

Selenium results in decreased expression of CNPY2 mRNA

NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519

G

canopy FGF signaling regulator 3

increases expression

Selenium results in increased expression of CNPY3 mRNA

NCBI chr 9:14,233,478...14,247,847
Ensembl chr 9:14,233,428...14,247,831

G

component of oligomeric golgi complex 4

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of COG4 mRNA

NCBI chr19:38,820,478...38,854,803
Ensembl chr19:38,820,501...38,854,796

G

component of oligomeric golgi complex 7

increases expression

Selenium results in increased expression of COG7 mRNA

NCBI chr 1:176,489,795...176,549,455
Ensembl chr 1:176,489,791...176,549,455

G

component of oligomeric golgi complex 8

increases expression

Selenium results in increased expression of COG8 mRNA

NCBI chr19:34,951,625...34,962,377
Ensembl chr19:34,951,627...34,962,397

G

collagen type XIV alpha 1 chain

decreases expression

Selenium results in decreased expression of COL14A1 mRNA

NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214

G

collagen type XVIII alpha 1 chain

increases expression

Selenium results in increased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

multiple interactions

[fulvic acid co-treated with Selenium deficiency] affects the metabolism of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type II alpha 1 chain

multiple interactions

[fulvic acid co-treated with Selenium deficiency] affects the metabolism of COL2A1 protein

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type IV alpha 3 chain

decreases expression

Selenium results in decreased expression of COL4A3 mRNA

NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895

G

collagen type VI alpha 2 chain

increases expression

Selenium results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collectin sub-family member 12

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

COMM domain containing 3

decreases expression

Selenium results in decreased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

G

COMM domain containing 4

increases expression

Selenium results in increased expression of COMMD4 mRNA

NCBI chr 8:57,566,236...57,569,701
Ensembl chr 8:57,566,236...57,569,760

G

COPI coat complex subunit epsilon

increases expression

Selenium results in increased expression of COPE mRNA

NCBI chr16:19,114,871...19,125,076
Ensembl chr16:19,114,871...19,128,907

G

COPI coat complex subunit gamma 1

increases expression

Selenium results in increased expression of COPG1 mRNA

NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616

G

COP9 signalosome subunit 7A

increases expression

Selenium results in increased expression of COPS7A mRNA

NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948

G

COP9 signalosome subunit 8

decreases expression

Selenium results in decreased expression of COPS8 mRNA

NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258

G

cytochrome c oxidase subunit 6A1

decreases expression

Selenium results in decreased expression of COX6A1 mRNA

NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041

G

cytochrome c oxidase subunit 7A1

decreases expression

Selenium results in decreased expression of COX7A1 mRNA

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

cytochrome c oxidase subunit 7A2

decreases expression

Selenium results in decreased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7B

decreases expression

Selenium results in decreased expression of COX7B mRNA

NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732

G

cytochrome c oxidase subunit 7C

decreases expression

Selenium results in decreased expression of COX7C mRNA

NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760

G

carboxypeptidase A3

decreases expression

Selenium results in decreased expression of CPA3 mRNA

NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203

G

carboxypeptidase D

decreases expression

Selenium results in decreased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

cleavage and polyadenylation specific factor 1

increases expression

Selenium results in increased expression of CPSF1 mRNA

NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934

G

cellular retinoic acid binding protein 2

increases expression

Selenium deficiency results in increased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

carnitine O-acetyltransferase

increases expression

Selenium results in increased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

cereblon

decreases expression

Selenium results in decreased expression of CRBN mRNA

NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938

G

cAMP responsive element binding protein 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CREB1 mRNA
Selenium inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of CREB1 protein]
Selenium results in decreased expression of CREB1 mRNA

PMID:19244175 PMID:30695686

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3

increases expression

Selenium results in increased expression of CREB3 mRNA

NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390

G

CREB binding protein

decreases expression

Selenium results in decreased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cysteine-rich with EGF-like domains 1

increases expression

Selenium results in increased expression of CRELD1 mRNA

NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499

G

CREB regulated transcription coactivator 1

increases expression

Selenium results in increased expression of CRTC1 mRNA

NCBI chr16:18,988,197...19,046,914
Ensembl chr16:18,988,250...19,043,381

G

crystallin beta-gamma domain containing 2

increases expression
multiple interactions

Selenium results in increased expression of CRYBG2 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of CRYBG2 mRNA

NCBI chr 5:146,286,406...146,318,417
Ensembl chr 5:146,286,925...146,323,666

G

colony stimulating factor 1

increases expression

Selenium results in increased expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

C-terminal Src kinase

increases expression

Selenium results in increased expression of CSK mRNA

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

casein kinase 1, alpha 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CSNK1A1 mRNA
Selenium results in decreased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

casein kinase 1, epsilon

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CSNK1E mRNA
Selenium results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

G

casein kinase 2 alpha 1

decreases expression

Selenium results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

casein kinase 2 beta

increases expression

Selenium results in increased expression of CSNK2B mRNA

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

G

chondroitin sulfate proteoglycan 4

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

centrosome and spindle pole associated protein 1

decreases expression
multiple interactions

Selenium results in decreased expression of CSPP1 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of CSPP1 mRNA

NCBI chr 5:9,077,161...9,192,402
Ensembl chr 5:9,077,161...9,193,377

G

cystatin C

increases expression

Selenium results in increased expression of CST3 mRNA

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

cystatin A

decreases expression

Selenium results in decreased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

C-terminal binding protein 1

increases expression

Selenium results in increased expression of CTBP1 mRNA

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

C-terminal binding protein 2

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CTBP2 mRNA
Selenium results in decreased expression of CTBP2 mRNA

NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222

G

chitobiase

decreases expression

Selenium results in decreased expression of CTBS mRNA

NCBI chr 2:235,340,520...235,355,091
Ensembl chr 2:235,340,547...235,355,091

G

CTD nuclear envelope phosphatase 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of CTDNEP1 mRNA
Selenium results in increased expression of CTDNEP1 mRNA

NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781

G

catenin alpha 1

increases expression

Selenium results in increased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin, beta like 1

increases expression

Selenium results in increased expression of CTNNBL1 mRNA

NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987

G

cathepsin A

increases expression

Selenium results in increased expression of CTSA mRNA

NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215

G

cathepsin B

increases expression

Selenium results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin O

decreases expression

Selenium results in decreased expression of CTSO mRNA

NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702

G

CUE domain containing 2

increases expression

Selenium results in increased expression of CUEDC2 mRNA

NCBI chr 1:245,192,057...245,200,594
Ensembl chr 1:245,192,063...245,200,339

G

cullin 3

decreases expression

Selenium results in decreased expression of CUL3 mRNA

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

cullin 4A

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

cullin 7

increases expression

Selenium results in increased expression of CUL7 mRNA

NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741

G

cutC copper transporter

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of CUTC mRNA
Selenium results in decreased expression of CUTC mRNA

NCBI chr 1:242,622,281...242,637,048
Ensembl chr 1:242,622,276...242,637,047

G

C-X-C motif chemokine ligand 1

increases expression

Selenium results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

increases expression

Selenium results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

Selenium results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

decreases expression

Selenium results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 4

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

CXXC finger protein 1

increases expression

Selenium results in increased expression of CXXC1 mRNA

NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551

G

cytochrome b561 family, member D2

increases expression

Selenium results in increased expression of CYB561D2 mRNA

NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759

G

cytochrome c, somatic

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CYCS mRNA]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]

PMID:27920530 PMID:34612572

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Selenium inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Selenium promotes the reaction [Plant Extracts results in increased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP27A1 mRNA]

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Selenium deficiency results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression

Selenium results in decreased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases expression

Selenium results in decreased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

Selenium deficiency results in increased expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Magnesium co-treated with Selenium co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP7A1 mRNA]

PMID:30031400 PMID:36464106

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

increases expression

Selenium deficiency results in increased expression of CYP7B1 mRNA; Selenium results in increased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

increases expression
multiple interactions

Selenium deficiency results in increased expression of CYP8B1 mRNA; Selenium results in increased expression of CYP8B1 mRNA
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP8B1 mRNA]

PMID:16170372 PMID:36464106

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

dishevelled associated activator of morphogenesis 1

decreases expression

Selenium results in decreased expression of DAAM1 mRNA

NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

Selenium results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

defender against cell death 1

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of DAD1 mRNA

NCBI chr15:27,677,286...27,697,120
Ensembl chr15:27,677,268...27,697,347

G

death-associated protein kinase 3

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DAPK3 mRNA
Selenium results in increased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

dynactin subunit 1

increases expression

Selenium results in increased expression of DCTN1 mRNA

NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815

G

doublecortin

multiple interactions

[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of DCX mRNA

NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476

G

dicarbonyl and L-xylulose reductase

increases expression

Selenium results in increased expression of DCXR mRNA

NCBI chr10:106,006,404...106,008,293

G

DDAH family member 2, ADMA-independent

increases expression

Selenium results in increased expression of DDAH2 mRNA

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

increases expression

Selenium results in increased expression of DDOST mRNA

NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413

G

DEAD-box helicase 17

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of DDX17 mRNA
Selenium results in decreased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 18

decreases expression
multiple interactions

Selenium results in decreased expression of DDX18 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of DDX18 mRNA

NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161

G

DEAD-box helicase 24

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DDX24 mRNA
Selenium results in decreased expression of DDX24 mRNA

NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927

G

DExD-box helicase 39B

decreases expression
increases expression

Selenium results in decreased expression of DDX39B mRNA
Selenium results in increased expression of DDX39B mRNA

NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996

G

DEAD box helicase 3, Y-linked

decreases expression

Selenium results in decreased expression of DDX3Y mRNA

NCBI chr Y:1,115,095...1,135,754
Ensembl chr Y:1,116,309...1,135,706

G

DEAD-box helicase 41

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DDX41 mRNA
Selenium results in increased expression of DDX41 mRNA

NCBI chr17:9,102,926...9,108,415
Ensembl chr17:9,103,010...9,108,415

G

DEAD-box helicase 49

increases expression

Selenium results in increased expression of DDX49 mRNA

NCBI chr16:19,125,388...19,133,042
Ensembl chr16:19,125,384...19,133,616

G

2,4-dienoyl-CoA reductase 2

increases expression

Selenium deficiency results in increased expression of DECR2 mRNA

NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479

G

death effector domain-containing

increases expression

Selenium results in increased expression of DEDD mRNA

NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332

G

delta(4)-desaturase, sphingolipid 1

decreases expression

Selenium results in decreased expression of DEGS1 mRNA

NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664

G

DENN domain containing 2B

increases expression

Selenium results in increased expression of DENND2B mRNA

NCBI chr 1:163,544,075...163,734,736
Ensembl chr 1:163,544,074...163,694,680

G

deoxyribose-phosphate aldolase

decreases expression

Selenium results in decreased expression of DERA mRNA

NCBI chr 4:170,663,689...170,742,469
Ensembl chr 4:170,663,665...170,758,865

G

desmin

increases expression

Selenium results in increased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

desumoylating isopeptidase 2

decreases expression

Selenium results in decreased expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

DiGeorge syndrome critical region gene 6

increases expression

Selenium results in increased expression of DGCR6 mRNA

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

DGCR8 microprocessor complex subunit

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of DGCR8 mRNA
Selenium results in increased expression of DGCR8 mRNA

NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242

G

24-dehydrocholesterol reductase

increases expression

Selenium results in increased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

increases expression

Selenium results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

deoxyhypusine synthase

increases expression
multiple interactions

Selenium results in increased expression of DHPS mRNA
[Selenium co-treated with Vitamin E] results in increased expression of DHPS mRNA

NCBI chr19:23,082,454...23,086,544
Ensembl chr19:23,082,448...23,086,881

G

dehydrogenase/reductase 4

increases expression

Selenium results in increased expression of DHRS4 mRNA

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127

G

dehydrogenase/reductase 7B

increases expression

Selenium results in increased expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076

G

DExH-box helicase 30

increases expression

Selenium results in increased expression of DHX30 mRNA

NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381

G

dicer 1 ribonuclease III

decreases expression

Selenium results in decreased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

iodothyronine deiodinase 1

decreases expression
increases expression
affects expression
increases activity
multiple interactions

Selenium deficiency results in decreased expression of DIO1 mRNA
Selenium results in increased expression of DIO1 mRNA
Selenium deficiency affects the expression of DIO1 mRNA
Selenium results in increased activity of DIO1 protein
Selenium inhibits the reaction [Iodine results in decreased activity of DIO1 protein]; Selenium inhibits the reaction [Iodine results in decreased expression of DIO1 mRNA]; Selenium inhibits the reaction [potassium iodate results in decreased activity of DIO1 protein]

PMID:16170372 PMID:16271152 PMID:16874406 PMID:16959840 PMID:17044649 More...

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

iodothyronine deiodinase 2

multiple interactions
increases activity

Selenium results in increased expression of and results in increased activity of DIO2 protein
Selenium results in increased activity of DIO2 protein

PMID:11425850 PMID:15471965

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

disco-interacting protein 2 homolog C

decreases expression

Selenium results in decreased expression of DIP2C mRNA

NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305

G

discs large MAGUK scaffold protein 1

decreases expression

Selenium results in decreased expression of DLG1 mRNA

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

dimethylglycine dehydrogenase

affects abundance

DMGDH gene SNP affects the abundance of Selenium

NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528

G

cyclin D binding myb-like transcription factor 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of DMTF1 mRNA
Selenium results in decreased expression of DMTF1 mRNA

NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967

G

DM1 locus, WD repeat containing

increases expression

Selenium results in increased expression of DMWD mRNA

NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593

G

Dmx-like 2

decreases expression

Selenium results in decreased expression of DMXL2 mRNA

NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DNAJA3 mRNA
Selenium results in decreased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B3

multiple interactions
decreases expression

[Selenium co-treated with Selenium] results in decreased expression of DNAJB3 mRNA
Selenium deficiency results in decreased expression of DNAJB3 mRNA

NCBI chr 9:88,795,542...88,796,555
Ensembl chr 9:88,795,488...88,796,560

G

DnaJ heat shock protein family (Hsp40) member B4

decreases expression

Selenium results in decreased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member C2

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of DNAJC2 mRNA

NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:13,270,191...13,297,431

G

DnaJ heat shock protein family (Hsp40) member C7

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of DNAJC7 mRNA

NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575

G

DnaJ heat shock protein family (Hsp40) member C9

decreases expression

Selenium results in decreased expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

DNA methyltransferase 1

affects activity

Selenium affects the activity of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

aspartyl aminopeptidase

increases expression

Selenium results in increased expression of DNPEP mRNA

NCBI chr 9:76,799,931...76,808,841
Ensembl chr 9:76,783,966...76,808,716

G

deoxyhypusine hydroxylase

increases expression
multiple interactions

Selenium results in increased expression of DOHH mRNA
[Selenium co-treated with Vitamin E] results in increased expression of DOHH mRNA

NCBI chr 7:8,321,466...8,326,305
Ensembl chr 7:8,321,466...8,326,289

G

dolichyldiphosphatase 1

increases expression

Selenium results in increased expression of DOLPP1 mRNA

NCBI chr 3:13,666,000...13,674,312
Ensembl chr 3:13,665,823...13,674,311

G

dihydropyrimidine dehydrogenase

decreases expression

Selenium results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

down-regulator of transcription 1

decreases expression

Selenium results in decreased expression of DR1 mRNA

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

developmentally regulated GTP binding protein 2

increases expression

Selenium results in increased expression of DRG2 mRNA

NCBI chr10:45,255,512...45,269,971
Ensembl chr10:45,255,507...45,269,969

G

desmocollin 2

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of DSC2 mRNA
Selenium results in decreased expression of DSC2 mRNA

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

G

dermatan sulfate epimerase

decreases expression

Selenium results in decreased expression of DSE mRNA

NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992

G

dual oxidase 1

increases expression

Selenium results in increased expression of DUOX1 mRNA

NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563

G

dual specificity phosphatase 8

increases expression

Selenium results in increased expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

decapping exoribonuclease

increases expression

Selenium results in increased expression of DXO mRNA

NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494

G

dymeclin

decreases expression

Selenium results in decreased expression of DYM mRNA

NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903

G

dynein cytoplasmic 1 heavy chain 1

increases expression

Selenium results in increased expression of DYNC1H1 mRNA

NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883

G

dynein light chain roadblock-type 1

decreases expression

Selenium results in decreased expression of DYNLRB1 mRNA

NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227

G

E2F transcription factor 1

increases expression

Selenium results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 4

increases expression

Selenium results in increased expression of E2F4 mRNA

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

E2F transcription factor 6

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of E2F6 mRNA
Selenium results in decreased expression of E2F6 mRNA

NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683

G

E4F transcription factor 1

increases expression

Selenium results in increased expression of E4F1 mRNA

NCBI chr10:13,471,478...13,495,018
Ensembl chr10:13,474,456...13,485,974

G

extracellular matrix protein 2

decreases expression

Selenium results in decreased expression of ECM2 mRNA

NCBI chr17:15,120,194...15,152,536
Ensembl chr17:15,120,196...15,152,516

G

ECSIT signaling integrator

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of ECSIT mRNA
Selenium results in increased expression of ECSIT mRNA

NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390

G

endothelial differentiation-related factor 1

increases expression

Selenium results in increased expression of EDF1 mRNA

NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363

G

endothelin receptor type A

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNA
Selenium results in decreased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

eukaryotic translation elongation factor 1 alpha 2

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of EEF1A2 mRNA
Selenium results in increased expression of EEF1A2 mRNA

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

eukaryotic translation elongation factor 1 delta

increases expression

Selenium results in increased expression of EEF1D mRNA

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

EF-hand calcium binding domain 14

increases expression

Selenium results in increased expression of EFCAB14 mRNA

NCBI chr 5:129,218,139...129,258,628
Ensembl chr 5:129,218,424...129,258,625

G

EGF containing fibulin extracellular matrix protein 2

increases expression

Selenium results in increased expression of EFEMP2 mRNA

NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414

G

EF-hand domain containing 1

decreases expression

Selenium results in decreased expression of EFHC1 mRNA

NCBI chr 9:23,375,815...23,414,283
Ensembl chr 9:23,375,840...23,414,283

G

EF-hand domain family, member D2

increases expression

Selenium results in increased expression of EFHD2 mRNA

NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980

G

epidermal growth factor

multiple interactions

Selenium inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]; Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression

Selenium results in decreased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EH domain binding protein 1

decreases expression

Selenium results in decreased expression of EHBP1 mRNA

NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332

G

EH-domain containing 2

increases expression

Selenium results in increased expression of EHD2 mRNA

NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783

G

eukaryotic translation initiation factor 1B

decreases expression

Selenium results in decreased expression of EIF1B mRNA

NCBI chr 8:120,203,561...120,206,176
Ensembl chr 8:120,203,451...120,206,176
Ensembl chr 5:120,203,451...120,206,176

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

Selenium results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 3, subunit A

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of EIF3A mRNA

NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 3, subunit B

increases expression

Selenium results in increased expression of EIF3B mRNA

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit C

increases expression

Selenium results in increased expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 4 gamma 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA
Selenium results in increased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

eukaryotic translation initiation factor 5A

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of IF2 mRNA
Selenium results in decreased expression of IF2 mRNA

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

eukaryotic translation initiation factor 6

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of EIF6 mRNA
Selenium results in increased expression of EIF6 mRNA

NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401

G

elongin A

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of ELOA mRNA

NCBI chr 5:148,231,600...148,246,760
Ensembl chr 5:148,231,596...148,246,765

G

elongator acetyltransferase complex subunit 1

decreases expression

Selenium results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

ER membrane protein complex subunit 9

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of EMC9 mRNA

NCBI chr15:29,071,881...29,076,098
Ensembl chr15:29,071,883...29,076,098

G

elastin microfibril interfacer 1

increases expression

Selenium results in increased expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

EMAP like 2

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of EML2 mRNA
Selenium results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

epithelial membrane protein 2

increases expression

Selenium results in increased expression of EMP2 mRNA

NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733

G

epithelial membrane protein 3

increases expression

Selenium results in increased expression of EMP3 mRNA

NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988

G

EMSY transcriptional repressor, BRCA2 interacting

decreases expression

Selenium results in decreased expression of EMSY mRNA

NCBI chr 1:152,881,485...152,960,420
Ensembl chr 1:152,883,992...152,953,528

G

endonuclease G

increases expression

Selenium results in increased expression of ENDOG mRNA

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

endoglin

increases expression

Selenium results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 2

increases expression

Selenium results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

decreases expression

Selenium results in decreased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

erythrocyte membrane protein band 4.1 like 4B

decreases expression

Selenium results in decreased expression of EPB41L4B mRNA

NCBI chr 5:71,691,706...71,852,583
Ensembl chr 5:71,694,331...71,851,990

G

Eph receptor B6

increases expression

Selenium results in increased expression of EPHB6 mRNA

NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230

G

epoxide hydrolase 2

increases expression

Selenium results in increased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

epsin 2

increases expression

Selenium results in increased expression of EPN2 mRNA

NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642

G

erb-b2 receptor tyrosine kinase 2

increases expression
multiple interactions

Selenium results in increased expression of ERBB2 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

Selenium results in increased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERGIC and golgi 3

increases expression

Selenium results in increased expression of ERGIC3 mRNA

NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813

G

estrogen receptor 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

epithelial splicing regulatory protein 2

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of ESRP2 mRNA

NCBI chr19:34,034,559...34,041,726
Ensembl chr19:34,034,559...34,041,726

G

ess-2 splicing factor homolog

increases expression

Selenium results in increased expression of ESS2 mRNA

NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846

G

EvC ciliary complex subunit 1

increases expression

Selenium results in increased expression of EVC mRNA

NCBI chr14:73,456,181...73,498,955
Ensembl chr14:73,456,222...73,498,099

G

ecotropic viral integration site 5

decreases expression

Selenium results in decreased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

EWS RNA-binding protein 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of EWSR1 mRNA
Selenium results in increased expression of EWSR1 mRNA

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

G

exocyst complex component 3

increases expression

Selenium results in increased expression of SEC6 mRNA

NCBI chr 1:29,091,298...29,122,056
Ensembl chr 1:29,091,294...29,122,045

G

exosome component 4

increases expression

Selenium results in increased expression of EXOSC4 mRNA

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

exosome component 8

decreases expression

Selenium results in decreased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

G

exostosin glycosyltransferase 1

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of EXT1 mRNA

NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357

G

exostosin glycosyltransferase 2

decreases expression

Selenium results in decreased expression of EXT2 mRNA

NCBI chr 3:79,665,414...79,798,077
Ensembl chr 3:79,665,415...79,798,059

G

EYA transcriptional coactivator and phosphatase 2

increases expression

Selenium results in increased expression of EYA2 mRNA

NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793

G

ezrin

decreases expression
multiple interactions

Selenium results in decreased expression of EZR mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

F11 receptor

increases expression

Selenium results in increased expression of F11R mRNA

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor II (thrombin) receptor

decreases expression
multiple interactions

Selenium results in decreased expression of F2R mRNA
[Selenium co-treated with Vitamin E] results in increased expression of F2R mRNA

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

fatty acid amide hydrolase

increases expression

Selenium results in increased expression of FAAH mRNA

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

Fas associated via death domain

multiple interactions
increases expression

[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]; [Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA]; Selenium analog inhibits the reaction [Diazinon results in decreased expression of FADD mRNA]
Selenium results in increased expression of FADD protein

PMID:17970047 PMID:27920530

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

fatty acid desaturase 3

increases expression

Selenium results in increased expression of FADS3 mRNA

NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769

G

family with sequence similarity 107, member A

increases expression

Selenium results in increased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

FAM111 trypsin like peptidase A

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of FAM111A mRNA
Selenium results in decreased expression of FAM111A mRNA

NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547

G

family with sequence similarity 149, member A

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of FAM149A mRNA
Selenium results in decreased expression of FAM149A mRNA

NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066

G

family with sequence similarity 32, member A

increases expression

Selenium results in increased expression of FAM32A mRNA

NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398

G

FAM3 metabolism regulating signaling molecule A

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of FAM3A mRNA
Selenium results in increased expression of FAM3A mRNA

NCBI chr X:152,166,716...152,175,327
Ensembl chr X:152,165,535...152,175,362

G

family with sequence similarity 50, member A

increases expression

Selenium results in increased expression of FAM50A mRNA

NCBI chr X:152,095,245...152,102,362
Ensembl chr X:152,095,245...152,102,362

G

family with sequence similarity 53, member B

increases expression

Selenium results in increased expression of FAM53B mRNA

NCBI chr 1:187,500,061...187,591,186
Ensembl chr 1:187,500,066...187,591,186

G

FANCD2 and FANCI associated nuclease 1

decreases expression

Selenium results in decreased expression of FAN1 mRNA

NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases expression

Selenium results in increased expression of FARP1 mRNA

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

G

phenylalanyl-tRNA synthetase subunit alpha

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of FARSA mRNA
Selenium results in increased expression of FARSA mRNA

NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980

G

Fas cell surface death receptor

multiple interactions

[Doxorubicin co-treated with Selenium] promotes the reaction [FAS protein binds to CASP8 protein]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of FAS mRNA]; Selenium analog inhibits the reaction [Diazinon results in increased expression of FAS mRNA]

PMID:17970047 PMID:27920530

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

[Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FASLG mRNA]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

increases expression
multiple interactions

Selenium results in increased expression of FASN mRNA
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of FASN mRNA]

PMID:19022953 PMID:19244175 PMID:36464106

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAT atypical cadherin 4

decreases expression

Selenium results in decreased expression of FAT4 mRNA

NCBI chr 2:121,927,266...122,056,700
Ensembl chr 2:121,927,942...122,056,707

G

fatty acid hydroxylase domain containing 2

decreases expression

Selenium results in decreased expression of FAXDC2 mRNA

NCBI chr10:42,245,808...42,271,679
Ensembl chr10:42,246,868...42,271,871

G

fibulin 1

increases expression

Selenium results in increased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

fibulin 5

increases expression

Selenium results in increased expression of FBLN5 mRNA

NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755

G

fructose-bisphosphatase 1

increases expression

Selenium results in increased expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

F-box and leucine-rich repeat protein 5

decreases expression

Selenium results in decreased expression of FBXL5 mRNA

NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383

G

F-box and leucine-rich repeat protein 8

increases expression

Selenium results in increased expression of FBXL8 mRNA

NCBI chr19:33,142,705...33,147,266
Ensembl chr19:33,142,715...33,147,262

G

F-box protein 11

decreases expression

Selenium results in decreased expression of FBXO11 mRNA

NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662

G

F-box protein 17

increases expression

Selenium results in increased expression of FBXO17 mRNA

NCBI chr 1:84,002,276...84,024,455
Ensembl chr 1:84,002,267...84,024,453

G

F-box protein 2

increases expression

Selenium results in increased expression of FBXO2 mRNA

NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355

G

F-box protein 28

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of FBXO28 mRNA
Selenium results in decreased expression of FBXO28 mRNA

NCBI chr13:93,995,993...94,021,464
Ensembl chr13:93,995,996...94,021,464

G

Fc gamma receptor and transporter

increases expression

Selenium results in increased expression of FCGRT mRNA

NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084

G

farnesyl diphosphate farnesyl transferase 1

increases expression

Selenium deficiency results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

ferrochelatase

decreases expression

Selenium results in decreased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

FERM domain containing kindlin 1

decreases expression

Selenium results in decreased expression of FERMT1 mRNA

NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555

G

free fatty acid receptor 2

increases expression

Selenium results in increased expression of FFAR2 mRNA

NCBI chr 1:86,071,855...86,075,049
Ensembl chr 1:86,072,184...86,075,033

G

fibrinogen gamma chain

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

formin homology 2 domain containing 3

decreases expression

Selenium results in decreased expression of FHOD3 mRNA

NCBI chr18:15,993,079...16,425,796
Ensembl chr18:15,993,324...16,425,796

G

FIG4 phosphoinositide 5-phosphatase

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of FIG4 mRNA
Selenium results in decreased expression of FIG4 mRNA

NCBI chr20:44,600,603...44,724,047
Ensembl chr20:44,600,603...44,723,844

G

fission, mitochondrial 1

increases expression

Selenium results in increased expression of FIS1 mRNA

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

FKBP prolyl isomerase 1A

increases expression
multiple interactions

Selenium results in increased expression of FKBP1A mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

FKBP prolyl isomerase 3

decreases expression

Selenium results in decreased expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

FLII, actin remodeling protein

increases expression

Selenium results in increased expression of FLII mRNA

NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970

G

filamin A

increases expression

Selenium results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

flotillin 1

increases expression

Selenium results in increased expression of FLOT1 mRNA

NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978

G

flotillin 2

increases expression

Selenium results in increased expression of FLOT2 mRNA

NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756

G

fibronectin leucine rich transmembrane protein 3

decreases expression

Selenium results in decreased expression of FLRT3 mRNA

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

folate hydrolase 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of FOLH1 mRNA
Selenium results in decreased expression of FOLH1 mRNA

NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Selenium results in increased expression of FOS mRNA; Selenium results in increased expression of FOS protein
[Selenium co-treated with Iodine] results in increased expression of FOS mRNA; [Selenium co-treated with Iodine] results in increased expression of FOS protein

PMID:12475444 PMID:12666833

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box F2

decreases expression

Selenium results in decreased expression of FOXF2 mRNA

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

forkhead box O1

multiple interactions

Selenium inhibits the reaction [arsenite results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

multiple interactions

Selenium results in decreased phosphorylation of and results in increased activity of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

FRAT regulator of WNT signaling pathway 1

increases expression

Selenium results in increased expression of FRAT1 mRNA

NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945

G

follicle stimulating hormone subunit beta

multiple interactions

Selenium inhibits the reaction [Acrylamide results in decreased expression of FSHB protein]; Selenium inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein]

PMID:20957662 PMID:37987225

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

ferritin light chain 1

increases expression

Selenium results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

Fus RNA binding protein

increases expression

Selenium results in increased expression of FUS mRNA

NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414

G

FMR1 autosomal homolog 1

decreases expression

Selenium results in decreased expression of FXR1 mRNA

NCBI chr 2:116,884,167...116,937,590
Ensembl chr 2:116,884,248...116,937,590

G

frizzled class receptor 7

decreases expression

Selenium results in decreased expression of FZD7 mRNA

NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781

G

fizzy and cell division cycle 20 related 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of FZR1 mRNA
Selenium results in increased expression of FZR1 mRNA

NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952

G

G0/G1switch 2

increases expression

Selenium results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GALNT1 mRNA
Selenium results in decreased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

glucosidase II alpha subunit

increases expression

Selenium results in increased expression of GANAB mRNA

NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Selenium results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest specific 8

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GAS8 mRNA
Selenium results in increased expression of GAS8 mRNA

NCBI chr19:51,552,770...51,572,323
Ensembl chr19:51,552,816...51,572,305

G

GATA zinc finger domain containing 2A

increases expression

Selenium results in increased expression of GATAD2A mRNA

NCBI chr16:19,429,578...19,520,320
Ensembl chr16:19,429,578...19,519,587

G

guanylate binding protein 1

decreases expression

Selenium results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glycine C-acetyltransferase

increases expression

Selenium results in increased expression of GCAT mRNA

NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

GDP-L-fucose synthase

increases expression

Selenium results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

G

geranylgeranyl diphosphate synthase 1

decreases expression

Selenium results in decreased expression of GGPS1 mRNA

NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220

G

gamma-glutamyltransferase 1

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of GGT1 mRNA
Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]; Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]

PMID:19244175 PMID:24485406

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

GIPC PDZ domain containing family, member 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of GIPC1 mRNA
Selenium results in increased expression of GIPC1 mRNA

NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997

G

gap junction protein, beta 1

increases expression

Selenium results in increased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

golgi glycoprotein 1

decreases expression
increases expression

Selenium results in decreased expression of GLG1 mRNA
Selenium results in increased expression of GLG1 mRNA

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178

G

GLI family zinc finger 2

increases expression

Selenium results in increased expression of GLI2 mRNA

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

glomulin, FKBP associated protein

decreases expression

Selenium results in decreased expression of GLMN mRNA

NCBI chr14:2,187,144...2,231,295
Ensembl chr14:2,187,642...2,230,420

G

glutaredoxin

increases expression
affects expression

Selenium deficiency results in increased expression of GLRX mRNA; Selenium results in increased expression of GLRX mRNA
Selenium affects the expression of GLRX mRNA

PMID:16170372 PMID:19351701

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

glutaredoxin 2

affects activity
affects expression

Selenium affects the activity of GLRX2 protein
Selenium affects the expression of GLRX2 protein

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

glutamate dehydrogenase 1

affects expression

Selenium affects the expression of GLUD1 protein

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

geminin, DNA replication inhibitor

decreases expression

Selenium results in decreased expression of GMNN mRNA

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

G

GDP-mannose pyrophosphorylase A

increases expression

Selenium results in increased expression of GMPPA mRNA

NCBI chr 9:76,926,724...76,934,274
Ensembl chr 9:76,926,739...76,934,269

G

guanosine monophosphate reductase 2

increases expression

Selenium results in increased expression of GMPR2 mRNA

NCBI chr15:29,165,421...29,175,933
Ensembl chr15:29,165,783...29,174,935

G

G protein subunit alpha i2

increases expression

Selenium results in increased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

GNAS complex locus

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GNAS mRNA
Selenium results in decreased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit beta 2

increases expression

Selenium results in increased expression of GNB2 mRNA

NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019

G

G protein nucleolar 1

increases expression

Selenium results in increased expression of GNL1 mRNA

NCBI chr20:2,783,130...2,792,115
Ensembl chr20:2,778,985...2,792,115

G

glycine N-methyltransferase

affects activity

Selenium affects the activity of GNMT protein

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glucosamine (N-acetyl)-6-sulfatase

decreases expression

Selenium results in decreased expression of GNS mRNA

NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151

G

golgin A3

increases expression
multiple interactions

Selenium results in increased expression of GOLGA3 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of GOLGA3 mRNA

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
Ensembl chr 4:46,454,870...46,500,509

G

golgi reassembly stacking protein 1

increases expression

Selenium results in increased expression of GORASP1 mRNA

NCBI chr 8:119,655,267...119,667,022
Ensembl chr 8:119,655,268...119,666,972

G

golgi SNAP receptor complex member 1

decreases expression

Selenium results in decreased expression of GOSR1 mRNA

NCBI chr10:61,570,499...61,607,287
Ensembl chr10:61,450,494...61,607,177
Ensembl chr10:61,450,494...61,607,177

G

glucose-6-phosphate isomerase

increases expression

Selenium results in increased expression of GPI mRNA

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

G patch domain and KOW motifs

increases expression

Selenium results in increased expression of GPKOW mRNA

NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384

G

G protein-coupled receptor 107

increases expression

Selenium results in increased expression of GPR107 mRNA

NCBI chr 3:14,431,704...14,497,623
Ensembl chr 3:14,434,723...14,495,958

G

G protein-coupled receptor 137

increases expression

Selenium results in increased expression of GPR137 mRNA

NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082

G

G protein-coupled receptor 137B

decreases expression

Selenium results in decreased expression of GPR137B mRNA

NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835

G

G protein regulated inducer of neurite outgrowth 2

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of GPRIN2 mRNA

NCBI chr16:9,496,452...9,512,672
Ensembl chr16:9,505,643...9,507,010

G

glutamic--pyruvic transaminase

multiple interactions

[[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; [Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in increased activity of GPT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Selenium inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]]
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased activity of GPT protein]

PMID:20688495 PMID:24485406 PMID:30031400 PMID:36464106 PMID:37676925

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

affects response to substance
decreases activity
increases activity
increases expression
decreases expression
multiple interactions
affects expression
affects activity

GPX1 gene polymorphism affects the susceptibility to Selenium; GPX1 protein polymorphism affects the susceptibility to Selenium
Selenium deficiency results in decreased activity of GPX1 protein
Selenium results in increased activity of GPX1 protein
Selenium results in increased expression of GPX1 mRNA; Selenium results in increased expression of GPX1 protein
Selenium deficiency results in decreased expression of GPX1 mRNA; Selenium deficiency results in decreased expression of GPX1 protein
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GPX1 mRNA; Selenium inhibits the reaction [2-iodohexadecanal results in decreased expression of GPX1 mRNA]; Selenium inhibits the reaction [arsenite results in decreased expression of GPX1 protein]; Selenium inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]; Selenium inhibits the reaction [Potassium Iodide results in decreased expression of GPX1 mRNA]; Selenium results in increased expression of and results in decreased degradation of GPX1 mRNA
Selenium affects the expression of GPX1 mRNA
Selenium affects the activity of GPX1 protein
Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]; Selenium deficiency results in decreased expression of and results in decreased activity of GPX1 protein
Selenium affects the expression of GPX1 mRNA; Selenium affects the expression of GPX1 protein

PMID:10874123 PMID:10949970 PMID:11294903 PMID:11444866 PMID:11463357 More...

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases activity
decreases expression

Selenium deficiency results in decreased activity of GPX2 protein
Selenium deficiency results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression
affects activity
increases activity
affects expression

Selenium results in increased expression of GPX3 mRNA
Selenium affects the activity of GPX3 protein
Selenium results in increased activity of GPX3 protein
Selenium affects the expression of GPX3 mRNA

PMID:15894816 PMID:19022953 PMID:19106321 PMID:19244175 PMID:19351701

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

increases activity
decreases expression
multiple interactions
increases expression
decreases activity
affects activity
decreases abundance

Selenium analog results in increased activity of GPX4 protein
Selenium deficiency results in decreased expression of GPX4 protein
Selenomethionine inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein]; Sodium Selenite inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein]
[2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] which results in increased expression of GPX4 protein
Selenium deficiency results in decreased expression of GPX4 mRNA
Selenium results in increased expression of GPX4 mRNA
Selenium deficiency results in decreased activity of GPX4 protein
Selenium affects the activity of GPX4 protein
Selenium results in increased activity of GPX4 protein
GPX4 gene mutant form results in decreased abundance of Selenium
Selenium results in increased expression of and results in increased activity of GPX4 protein
Selenium results in increased expression of GPX4 mRNA; Selenium results in increased expression of GPX4 protein

PMID:11673642 PMID:12031252 PMID:15670848 PMID:15792362 PMID:16246897 More...

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione peroxidase 5

affects expression

Selenium affects the expression of GPX5

NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

Selenium results in decreased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GRINA mRNA
Selenium results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

G protein-coupled receptor kinase 6

increases expression

Selenium results in increased expression of GRK6 mRNA

NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644

G

granulin precursor

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of GRN mRNA
Selenium results in increased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

gasdermin E

decreases expression

Selenium results in decreased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glycogen synthase kinase 3 alpha

increases expression

Selenium results in increased expression of GSK3A mRNA

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of GSK3B mRNA; Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]
Selenium results in decreased phosphorylation of GSK3B protein
Selenium results in decreased expression of GSK3B mRNA

PMID:17339365 PMID:19244175

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

Selenium results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

multiple interactions

Selenium inhibits the reaction [cyfluthrin results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

increases expression

Selenium deficiency results in increased expression of GSTA2 mRNA; Selenium results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

affects expression

Selenium affects the expression of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 5

increases expression

Selenium deficiency results in increased expression of GSTA5 mRNA; Selenium deficiency results in increased expression of GSTA5 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase pi 1

multiple interactions
affects expression
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GSTP1 mRNA
Selenium affects the expression of GSTP1 protein
Selenium results in increased expression of GSTP1 mRNA

PMID:7532609 PMID:19244175

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases expression

Selenium deficiency results in increased expression of GSTT1

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

general transcription factor IIF subunit 1

increases expression

Selenium results in increased expression of GTF2F1 mRNA

NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423

G

general transcription factor IIIC subunit 1

increases expression

Selenium results in increased expression of GTF3C1 mRNA

NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201

G

GTP binding protein 8

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of GTPBP8 mRNA
Selenium results in decreased expression of GTPBP8 mRNA

NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635

G

GULP PTB domain containing engulfment adaptor 1

decreases expression

Selenium results in decreased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

G

H2A.X variant histone

increases expression
multiple interactions

Selenium results in increased expression of H2AX mRNA
Selenium inhibits the reaction [Acrylamide results in increased expression of H2AX protein]

PMID:19244175 PMID:37987225

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H3.3 histone A

decreases expression

Selenium results in decreased expression of H3-3A mRNA

NCBI chr13:92,533,289...92,544,902
Ensembl chr13:92,533,298...92,544,908

G

histone H4C like 1

decreases expression

Selenium results in decreased expression of H4C6 mRNA

NCBI chr17:41,368,743...41,426,735

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of H6PD mRNA
Selenium results in increased expression of H6PD mRNA

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

Selenium results in decreased expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl glutathione hydrolase

increases expression

Selenium results in increased expression of HAGH mRNA

NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504

G

histidyl-tRNA synthetase 1

increases expression

Selenium results in increased expression of HARS1 mRNA

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

HAUS augmin-like complex, subunit 3

decreases expression
multiple interactions

Selenium results in decreased expression of HAUS3 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of HAUS3 mRNA

NCBI chr14:76,580,549...76,599,542
Ensembl chr14:76,580,546...76,752,463

G

HAUS augmin-like complex, subunit 4

increases expression

Selenium results in increased expression of HAUS4 mRNA

NCBI chr15:27,994,530...28,006,147
Ensembl chr15:27,994,532...28,005,938

G

hemoglobin alpha, adult chain 3

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of HBA2 mRNA

NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481

G

heparin binding growth factor

increases expression

Selenium results in increased expression of HDGF mRNA

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

high density lipoprotein binding protein

increases expression

Selenium results in increased expression of HDLBP mRNA

NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048

G

hephaestin

decreases expression

Selenium results in decreased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions

Selenium results in decreased expression of HES1 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hepatocyte growth factor-regulated tyrosine kinase substrate

increases expression

Selenium results in increased expression of HGS mRNA

NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835

G

Hedgehog-interacting protein

increases expression

Selenium results in increased expression of HHIP mRNA

NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528

G

huntingtin interacting protein 1 related

increases expression

Selenium results in increased expression of HIP1R mRNA

NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734

G

homeodomain interacting protein kinase 2

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HIPK2 mRNA
Selenium results in decreased expression of HIPK2 mRNA

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

G

HIRA interacting protein 3

increases expression

Selenium results in increased expression of HIRIP3 mRNA

NCBI chr 1:181,472,537...181,475,082
Ensembl chr 1:181,472,056...181,475,079

G

HLF transcription factor, PAR bZIP family member

decreases expression

Selenium results in decreased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

hydroxymethylbilane synthase

increases expression

Selenium results in increased expression of HMBS mRNA

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

high mobility group box 1

multiple interactions

[Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA]
[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA]

PMID:16581047 PMID:30031400 PMID:36464106

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

HMG-box containing 3

increases expression

Selenium results in increased expression of HMGXB3 mRNA

NCBI chr18:54,590,558...54,638,050
Ensembl chr18:54,590,560...54,638,155

G

HMG-box containing 4

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA
Selenium results in decreased expression of HMGXB4 mRNA

NCBI chr19:13,364,741...13,403,563
Ensembl chr19:13,364,807...13,403,563

G

heme oxygenase 1

multiple interactions
increases expression
affects expression
affects activity

[Arsenic co-treated with Selenium] results in increased expression of HMOX1 mRNA; [Arsenic co-treated with Selenium] results in increased expression of HMOX1 protein; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] affects the expression of HMOX1 mRNA; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of HMOX1 mRNA
Selenium deficiency results in increased expression of HMOX1 mRNA
Phenobarbital promotes the reaction [Selenium deficiency results in increased expression of and results in increased activity of HMOX1 protein]; Phenobarbital promotes the reaction [Selenium deficiency results in increased expression of HMOX1 mRNA]; Selenium deficiency results in increased expression of and results in increased activity of HMOX1 protein; Selenium inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Selenium affects the expression of HMOX1 protein
Selenium affects the activity of HMOX1 protein
NFE2L2 protein affects the reaction [Selenium affects the activity of HMOX1 protein]
Selenium results in increased expression of HMOX1 mRNA; Selenium results in increased expression of HMOX1 protein

PMID:12751798 PMID:16837816 PMID:18279678 PMID:20478284 PMID:21481475

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

H6 family homeobox 1

increases expression

Selenium results in increased expression of HMX1 mRNA

NCBI chr14:75,361,207...75,364,993
Ensembl chr14:75,361,225...75,364,993

G

HNF1 homeobox B

increases expression

Selenium results in increased expression of HNF1B mRNA

NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888

G

histamine N-methyltransferase

decreases expression
multiple interactions

Selenium results in decreased expression of HNMT mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

heterogeneous nuclear ribonucleoprotein D

increases expression

Selenium results in increased expression of HNRNPD mRNA

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

heterogeneous nuclear ribonucleoprotein M

increases expression

Selenium results in increased expression of HNRNPM mRNA

NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762

G

homer scaffold protein 1

decreases expression
multiple interactions

Selenium results in decreased expression of HOMER1 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

hook microtubule-tethering protein 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HOOK1 mRNA
Selenium results in decreased expression of HOOK1 mRNA

NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787

G

hippocalcin-like 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HPCAL1 mRNA
Selenium results in increased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

hematopoietic prostaglandin D synthase

multiple interactions

[Selenium deficiency co-treated with 4-(benzo(b)thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with 4-(benzo(b)thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein; [Selenium deficiency co-treated with rosiglitazone] results in increased expression of HPGDS protein

NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883

G

hepsin

increases expression

Selenium results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

HRas proto-oncogene, GTPase

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of HRAS mRNA
Selenium results in increased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate-glucosamine 3-sulfotransferase 3A1

decreases expression

Selenium results in decreased expression of HS3ST3A1 mRNA

NCBI chr10:49,092,850...49,180,676
Ensembl chr10:49,094,026...49,180,676

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions

[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSD11B2 mRNA]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSD11B2 protein]; [Sodium Selenite results in increased abundance of Selenium] which results in increased expression of HSD11B2 protein

PMID:11444866 PMID:35384129

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

Selenium deficiency results in increased expression of HSD17B11 mRNA; Selenium results in increased expression of HSD17B11 mRNA

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

Selenium inhibits the reaction [Acrylamide results in decreased expression of HSD17B3 mRNA]

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 8

increases expression

Selenium results in increased expression of HSD17B8 mRNA

NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742

G

heat shock protein 90 alpha family class A member 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HSP90AA1 mRNA
Selenium results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

Selenium results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of HSP90B1 mRNA
Selenium results in decreased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions

Selenium results in increased expression of HSPA1A mRNA; Selenium results in increased expression of HSPA1A protein
[Selenium co-treated with Fluorides] results in increased expression of HSPA1A mRNA; Fluorides promotes the reaction [Selenium results in increased expression of HSPA1A protein]

PMID:19244175 PMID:19652462

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 4

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 9

decreases expression
multiple interactions

Selenium results in decreased expression of HSPA9 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

increases expression

Selenium results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 2

decreases expression

Selenium results in decreased expression of HSPB2 mRNA

NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533

G

HSPB1 associated protein 1

decreases expression

Selenium results in decreased expression of HSPBAP1 mRNA

NCBI chr11:64,940,089...64,994,753
Ensembl chr11:64,940,091...64,994,756

G

5-hydroxytryptamine receptor 4

increases expression

Selenium results in increased expression of HTR4 mRNA

NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321

G

isoleucyl-tRNA synthetase 1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in increased expression of IARS1 mRNA
Selenium results in decreased expression of IARS1 mRNA

NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237

G

islet cell autoantigen 1

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of ICA1 mRNA
Selenium results in increased expression of ICA1 mRNA

NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298

G

inhibitor of DNA binding 1

increases expression

Selenium results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

decreases expression

Selenium results in decreased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

increases expression

Selenium results in increased expression of IDH3B mRNA

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of IDH3G mRNA
Selenium results in increased expression of IDH3G mRNA

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

G

alpha-L-iduronidase

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in increased expression of IDUA mRNA
Selenium results in increased expression of IDUA mRNA

NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522

G

immediate early response 3

increases expression

Selenium results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon-induced protein 35

increases expression

Selenium results in increased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon induced transmembrane protein 1

increases expression

Selenium results in increased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon induced transmembrane protein 2

increases expression

Selenium results in increased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

G

interferon induced transmembrane protein 3

increases expression

Selenium results in increased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon, alpha 1

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] affects the expression of IFNA1 mRNA

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

decreases expression

Selenium results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 2

increases expression

Selenium results in increased expression of IFRD2 mRNA

NCBI chr 8:108,260,969...108,266,191
Ensembl chr 8:108,260,969...108,266,194

G

intraflagellar transport 74

decreases expression
multiple interactions

Selenium results in decreased expression of IFT74 mRNA
[Selenium co-treated with Vitamin E] results in decreased expression of IFT74 mRNA

NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833

G

intraflagellar transport 81

decreases expression

Selenium results in decreased expression of IFT81 mRNA

NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057

G

insulin-like growth factor 2 receptor

decreases expression

Selenium results in decreased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 2

increases expression

Selenium results in increased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

insulin-like growth factor binding protein 3

increases expression

Selenium results in increased expression of IGFBP3 mRNA; Selenium results in increased expression of IGFBP3 protein

PMID:15318950 PMID:18997278

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 4

increases expression

Selenium results in increased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 6

increases expression

Selenium results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

IK cytokine

increases expression

Selenium results in increased expression of IK mRNA

NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of IKBKB protein]
[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IKBKB mRNA

PMID:17439952 PMID:21481475

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

[Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] inhibits the reaction [Streptozocin results in decreased expression of IL10 protein]; Selenium affects the reaction [Mercuric Chloride results in decreased expression of IL10 protein]
[Drugs, Chinese Herbal co-treated with Selenium] results in increased expression of IL10 mRNA
[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL10 mRNA; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IL10 mRNA

PMID:15862027 PMID:21481475 PMID:24626144 PMID:26089086

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

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interleukin 17 receptor C

increases expression

Selenium results in increased expression of IL17RC mRNA

NCBI chr 4:146,618,321...146,631,444
Ensembl chr 4:146,619,004...146,631,442

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interleukin 1 beta

multiple interactions
increases expression

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IL1B mRNA; Selenium affects the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Selenium inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Selenium promotes the reaction [T-2 Toxin results in increased expression of IL1B protein]
Selenium inhibits the reaction [Acrylamide results in increased expression of IL1B protein]
Selenium deficiency results in increased expression of IL1B mRNA
[Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of IL1B mRNA; Selenium inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
Selenium results in increased expression of IL1B mRNA

PMID:10802230 PMID:17293063 PMID:17630198 PMID:18196609 PMID:21481475 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor type 2

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

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interleukin 1 receptor accessory protein-like 2

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RAPL2 mRNA

NCBI chr X:100,961,509...102,271,753
Ensembl chr X:100,961,812...102,271,753

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interleukin 1 receptor-like 2

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RL2 mRNA

NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667

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interleukin 1 receptor antagonist

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

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interleukin 2

affects expression

Selenium affects the expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

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interleukin 4

decreases expression
multiple interactions

Selenium results in decreased expression of IL4 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased expression of MRC1 mRNA]; 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; [Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein; [Selenium co-treated with IL4 protein] results in increased expression of ARG1 mRNA; [Selenium co-treated with IL4 protein] results in increased expression of MRC1 mRNA; [Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of IL1B mRNA; [Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of TNF mRNA; leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; rosiglitazone promotes the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]
[Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein

PMID:14624943 PMID:15862027 PMID:21775527

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

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interleukin 4 receptor

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of IL4R mRNA
Selenium results in increased expression of IL4R mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IL6 mRNA
[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Selenium affects the reaction [Mercuric Chloride results in decreased expression of IL6 protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Selenium inhibits the reaction [Acrylamide results in increased expression of IL6 protein]

PMID:21481475 PMID:26089086 PMID:37676925 PMID:37987225

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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interleukin 6 cytokine family signal transducer

decreases expression

Selenium results in decreased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

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interleukin enhancer binding factor 3

multiple interactions

[Selenium co-treated with Vitamin E] results in increased expression of ILF3 mRNA

NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350

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integrin-linked kinase

increases expression

Selenium results in increased expression of ILK mRNA

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

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inflammation and lipid regulator with UBA-like and NBR1-like domains

increases expression

Selenium results in increased expression of ILRUN mRNA

NCBI chr20:5,809,931...5,876,197
Ensembl chr20:5,809,936...5,876,012

G

inositol polyphosphate-5-phosphatase K

increases expression

Selenium results in increased expression of INPP5K mRNA

NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773

G

insulin 1

multiple interactions

[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA; [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein]; Selenium analog inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; Selenium analog inhibits the reaction [Diazinon results in decreased secretion of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

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integrator complex subunit 1

increases expression

Selenium results in increased expression of INTS1 mRNA

NCBI chr12:14,861,312...14,886,048
Ensembl chr12:14,861,318...14,886,037

G

integrator complex subunit 15

increases expression

Selenium results in increased expression of INTS15 mRNA

NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166

G

integrator complex subunit 3

increases expression

Selenium results in increased expression of INTS3 mRNA

NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709

G

integrator complex subunit 6

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNA
Selenium results in decreased expression of INTS6 mRNA

NCBI chr15:36,908,966...37,048,043
Ensembl chr15:36,933,724...37,021,527

G

IQ motif containing B1

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of IQCB1 mRNA
Selenium results in decreased expression of IQCB1 mRNA

NCBI chr11:63,905,595...63,960,141
Ensembl chr11:63,905,590...63,960,093

G

IQ motif containing K

multiple interactions
decreases expression

[Selenium co-treated with Vitamin E] results in decreased expression of IQCK mRNA
Selenium results in decreased expression of IQCK mRNA

NCBI chr 1:173,199,308...173,316,982
Ensembl chr 1:173,199,316...173,316,984

G

interleukin-1 receptor-associated kinase 2

multiple interactions

[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

interferon regulatory factor 3

increases expression

Selenium results in increased expression of IRF3 mRNA

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

interferon regulatory factor 9

multiple interactions
increases expression

[Selenium co-treated with Vitamin E] results in decreased expression of IRF9 mRNA
Selenium results in increased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

inositol-3-phosphate synthase 1

increases expression

Selenium results in increased expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

integrin subunit alpha 3

increases expression
multiple interactions

Selenium results in increased expression of ITGA3 mRNA
[Selenium co-treated with Vitamin E] results in increased expression of ITGA3 mRNA

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha E

decreases expression

Selenium results in decreased expression of ITGAE mRNA

NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093