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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monoatomic bromine
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Accession:CHEBI:36896 term browser browse the term
Synonyms:related_synonym: Formula=Br;   atomic bromine


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3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr 7:113,385,677...113,428,794 JBrowse link
G Casp3 caspase 3 increases activity ISO thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 increases activity ISO thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases reduction
multiple interactions		 ISO NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]		 CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725 JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
NAN 190 hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP
ISO		 [1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine		 CTD PMID:15213358 PMID:15482641 PMID:16528294 NCBI chr 2:38,427,169...38,431,733 JBrowse link
pifithrin-alpha hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA] CTD PMID:20064835 NCBI chr 1:174,164,178...174,182,372 JBrowse link
G Agt angiotensinogen multiple interactions EXP pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein] CTD PMID:19808082 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization		 ISO pifithrin binds to and results in increased activity of AHR protein
pifithrin affects the localization of AHR protein		 CTD PMID:15843497 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] CTD PMID:15983031 NCBI chr  X:132,528,107...132,567,237 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein CTD PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO pifithrin results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr 7:27,381,392...27,466,772 JBrowse link
G App amyloid beta precursor protein multiple interactions EXP pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein] CTD PMID:24567336 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA] CTD PMID:26148435 NCBI chr13:105,274,103...105,331,653 JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein] CTD PMID:26259609 NCBI chr 8:62,724,939...62,829,040 JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] CTD PMID:30009776 NCBI chr20:5,102,334...5,111,615 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein]
pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]
pifithrin results in decreased expression of BAX protein		 CTD PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 More... NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
decreases expression		 ISO
EXP		 pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein		 CTD PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 More... NCBI chr 1:86,141,450...86,150,666 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein]		 CTD PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 More... NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO
EXP		 [Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]]
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]		 CTD PMID:15987750 PMID:21593185 PMID:30009776 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 4:155,785,366...155,808,775 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] CTD PMID:19812371 NCBI chr10:103,567,369...103,580,069 JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] CTD PMID:26259609 NCBI chr10:86,917,693...86,978,012 JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions ISO pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]] CTD PMID:22886373 NCBI chr 3:126,017,019...126,069,470 JBrowse link
G C3 complement C3 multiple interactions EXP pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein] CTD PMID:32924446 NCBI chr 9:2,174,412...2,201,339 JBrowse link
G C5 complement C5 multiple interactions EXP pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein] CTD PMID:32924446 NCBI chr 3:38,668,174...38,759,468 JBrowse link
G Casp12 caspase 12 multiple interactions EXP pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:16687611 NCBI chr 8:10,927,188...10,954,442 JBrowse link
G Casp2 caspase 2 multiple interactions ISO
EXP		 pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]		 CTD PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371 NCBI chr 4:72,116,265...72,134,023 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity
decreases expression		 EXP
ISO		 pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
pifithrin results in increased cleavage of CASP3 protein
pifithrin results in decreased activity of CASP3 protein
[pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]
pifithrin results in decreased expression of CASP3 protein
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein]		 CTD PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 More... NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp7 caspase 7 multiple interactions EXP
ISO		 pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]
pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]		 CTD PMID:24704558 PMID:26259609 NCBI chr 1:265,442,647...265,481,938 JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP		 pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]		 CTD PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]		 CTD PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 More...
G Ccnb1 cyclin B1 multiple interactions
increases expression		 ISO [pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein
pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein		 CTD PMID:16620711 PMID:18516295 NCBI chr 2:33,646,252...33,655,225 JBrowse link
G Ccng1 cyclin G1 multiple interactions EXP pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA] CTD PMID:17487067 NCBI chr10:25,678,503...25,684,876 JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO [pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA CTD PMID:35030298 NCBI chr14:15,088,694...15,097,190 JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA] CTD PMID:26148435 NCBI chr 8:118,742,824...118,761,190 JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein CTD PMID:18516295 NCBI chr18:26,608,483...26,630,292 JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]
pifithrin results in decreased expression of CDH1 protein		 CTD PMID:32687844 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
increases phosphorylation		 ISO pifithrin results in increased expression of CDK1 protein
[pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein
pifithrin results in increased phosphorylation of CDK1 protein		 CTD PMID:16620711 PMID:18516295 NCBI chr20:19,265,252...19,280,456 JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein] CTD PMID:26451628 NCBI chr 7:1,714,392...1,721,964 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression		 ISO
EXP		 pifithrin results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]
pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
pifithrin results in decreased expression of CDKN1A protein		 CTD PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 More... NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein] CTD PMID:26259609 NCBI chr12:51,448,838...51,481,159 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]] CTD PMID:21660965 NCBI chr 1:12,312,426...12,314,869 JBrowse link
G Crebbp CREB binding protein multiple interactions EXP pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] CTD PMID:13679428 NCBI chr10:11,842,307...11,968,266 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA] CTD PMID:20064835 NCBI chr13:42,630,383...42,634,288 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] CTD PMID:16687611 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression		 ISO pifithrin results in decreased activity of CYP1A1 protein
pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein		 CTD PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO pifithrin results in decreased activity of CYP1A2 protein
pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein		 CTD PMID:16258175 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
decreases activity		 ISO pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]
pifithrin results in increased expression of CYP1B1 mRNA
pifithrin results in decreased activity of CYP1B1 protein		 CTD PMID:16258175 PMID:35908932 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA] CTD PMID:20064835 PMID:27694624 NCBI chr 3:77,185,114...77,207,650 JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA] CTD PMID:20064835 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO pifithrin results in decreased expression of EDN1 mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]		 CTD PMID:19098008 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Ednrb endothelin receptor type B decreases expression ISO pifithrin results in decreased expression of EDNRB mRNA CTD PMID:19098008 NCBI chr15:87,055,490...87,086,765 JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] CTD PMID:24361490 NCBI chr12:22,151,211...22,158,264 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP		 pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein] CTD PMID:11779855 PMID:16687611 PMID:26451628 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fdxr ferredoxin reductase multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA] CTD PMID:20064835 NCBI chr10:100,507,863...100,516,649 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA] CTD PMID:20064835 NCBI chr 1:88,082,324...88,089,506 JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein] CTD PMID:32687844 NCBI chr 1:216,052,037...216,054,325 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA]		 CTD PMID:20064835 PMID:20955365 NCBI chr 4:97,484,497...97,486,799 JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA] CTD PMID:20064835 NCBI chr16:18,838,436...18,842,022 JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] CTD PMID:33737050 NCBI chr 8:122,963,718...123,036,326 JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] CTD PMID:33737050 NCBI chr 7:10,300,833...10,303,629 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]
[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein]		 CTD PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949 NCBI chr 8:53,568,718...53,570,072 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions		 EXP pifithrin results in increased phosphorylation of IKBKB protein
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]		 CTD PMID:31618665 NCBI chr16:76,021,968...76,075,717 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO pifithrin results in increased expression of JUN protein CTD PMID:16061640 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO pifithrin results in decreased expression of KIT mRNA CTD PMID:19098008 NCBI chr14:32,901,615...32,978,895 JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions		 ISO pifithrin results in decreased expression of KITLG mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]		 CTD PMID:19098008 NCBI chr 7:36,782,621...36,863,796 JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO pifithrin results in increased expression of LASP1 mRNA CTD PMID:28232485 NCBI chr10:83,290,820...83,331,989 JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein] CTD PMID:38431053 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA] CTD PMID:18550754 NCBI chr 7:52,906,810...52,912,154 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression		 EXP
ISO		 pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
pifithrin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]
pifithrin results in increased expression of MAPK1 protein modified form		 CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions EXP pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein] CTD PMID:16687611 NCBI chr14:6,802,247...7,094,103 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation		 EXP
ISO		 pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein]
pifithrin results in increased phosphorylation of MAPK14 protein		 CTD PMID:16005925 PMID:16061640 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
increases phosphorylation		 ISO
EXP		 pifithrin results in increased expression of MAPK3 protein modified form
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]
pifithrin results in increased phosphorylation of MAPK8 protein		 CTD PMID:16061640 PMID:16777994 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP		 pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein]		 CTD PMID:16687611 PMID:16777994 NCBI chr10:34,670,750...34,711,972 JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO pifithrin results in decreased expression of MC1R mRNA CTD PMID:19098008 NCBI chr19:68,360,950...68,363,877 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP
ISO		 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA]
pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]		 CTD PMID:14766674 PMID:17487067 PMID:18940243 NCBI chr 7:55,176,558...55,201,757 JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein CTD PMID:19098008 NCBI chr 4:131,965,676...132,177,790 JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein] CTD PMID:18557930 NCBI chr 8:12,943,453...12,963,966 JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
multiple interactions		 ISO pifithrin results in increased expression of MTOR protein
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein]		 CTD PMID:32687844 NCBI chr 5:164,167,985...164,277,438 JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression		 ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
pifithrin results in decreased expression of NCOA4 protein		 CTD PMID:32687844 NCBI chr16:7,395,502...7,415,846 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16061640 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation EXP pifithrin results in increased phosphorylation of NFKBIA protein CTD PMID:31618665 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] CTD PMID:26086121 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 NCBI chr 3:29,676,040...29,721,613 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP		 [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein]
pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]		 CTD PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 More... NCBI chr13:94,839,484...94,871,295 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA] CTD PMID:17487067 NCBI chr 3:139,951,948...139,955,820 JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA] CTD PMID:15983031 NCBI chr 1:205,966,392...205,972,359 JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein] CTD PMID:38431053 NCBI chr 8:68,949,731...68,975,394 JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein CTD PMID:18516295 NCBI chr 1:186,147,658...186,157,637 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 decreases expression
multiple interactions		 ISO
EXP		 pifithrin results in decreased expression of PMAIP1 protein
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein]		 CTD PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897 NCBI chr18:62,255,970...62,262,384 JBrowse link
G Polh DNA polymerase eta multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein] CTD PMID:25125662 PMID:27694624 NCBI chr 9:14,778,355...14,813,210 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein CTD PMID:24535669 NCBI chr 2:55,967,766...56,003,450 JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein] CTD PMID:22226932 NCBI chr11:98,544,952...98,762,499 JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]] CTD PMID:12556443 NCBI chr13:94,499,451...94,528,419 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 NCBI chr 1:240,043,707...240,110,330 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein] CTD PMID:29484840 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein] CTD PMID:27989139 NCBI chr 3:126,554,210...126,578,888 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein CTD PMID:18516295 NCBI chr 4:150,352,158...150,412,813 JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions EXP pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein] CTD PMID:18683188 NCBI chr15:54,780,858...54,911,989 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 EXP
ISO		 pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein]
pifithrin results in increased expression of RELA protein
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein]		 CTD PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions EXP pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein] CTD PMID:32924446 NCBI chr 2:178,487,941...178,490,622 JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA] CTD PMID:26148435 NCBI chr20:46,876,918...46,970,010 JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein
pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]		 CTD PMID:24535669 PMID:26031332 PMID:35030298 NCBI chr 5:149,986,304...150,005,255 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP
ISO		 pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein]
pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]		 CTD PMID:31618665 PMID:38431053 NCBI chr 5:138,002,522...138,030,742 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein] CTD PMID:31618665 NCBI chr10:55,164,721...55,170,289 JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein] CTD PMID:33737050 NCBI chr 2:136,532,912...136,668,560 JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions		 ISO pifithrin results in increased expression of SNAI1 protein
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]		 CTD PMID:20064835 PMID:32687844 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO pifithrin results in increased expression of SNAI2 protein CTD PMID:32687844 NCBI chr11:99,686,934...99,690,349 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein] CTD PMID:19226370 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sox30 SRY-box transcription factor 30 multiple interactions ISO pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein] CTD PMID:25435374 NCBI chr10:30,417,499...30,446,441 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein] CTD PMID:32199951 NCBI chr16:72,969,824...72,974,447 JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
decreases expression		 EXP TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein] CTD PMID:12143041 NCBI chr 4:120,175,549...120,258,342 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tp53 tumor protein p53 decreases activity
decreases expression
multiple interactions
decreases phosphorylation
affects expression		 EXP
ISO		 pifithrin results in decreased activity of TP53 protein
pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]
pifithrin results in decreased phosphorylation of TP53 protein
pifithrin affects the expression of TRP53 protein
[pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein]
pifithrin results in decreased activity of TRP53 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]		 CTD PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 More... NCBI chr10:54,798,871...54,810,300 JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:26259609 NCBI chr 3:108,166,574...108,270,229 JBrowse link
G Tyr tyrosinase decreases expression ISO pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein CTD PMID:19098008 NCBI chr 1:150,527,687...150,622,857 JBrowse link
G Usp8 ubiquitin specific peptidase 8 multiple interactions ISO pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein] CTD PMID:35022897 NCBI chr 3:113,962,136...114,009,683 JBrowse link
G Vim vimentin multiple interactions ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein] CTD PMID:32687844 NCBI chr17:81,577,261...81,585,746 JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein] CTD PMID:19812371 NCBI chr  X:125,756,107...125,803,979 JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA] CTD PMID:27694624 NCBI chr 4:123,993,670...124,020,922 JBrowse link
sodium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:12488351 NCBI chr16:18,546,709...18,556,698 JBrowse link
tiotropium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO Tiotropium Bromide binds to CHRM1 protein CTD PMID:21870878 NCBI chr 1:205,567,226...205,583,001 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding ISO Tiotropium Bromide binds to CHRM2 protein CTD PMID:21870878 NCBI chr 4:65,981,136...66,116,128 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding ISO Tiotropium Bromide binds to CHRM3 protein CTD PMID:21870878 NCBI chr17:64,696,549...65,158,622 JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding ISO Tiotropium Bromide binds to CHRM4 protein CTD PMID:21870878 NCBI chr 3:98,349,080...98,356,821 JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects binding ISO Tiotropium Bromide binds to CHRM5 protein CTD PMID:21870878 NCBI chr 3:99,284,846...99,337,252 JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:34,261,312...34,292,327 JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Tiotropium Bromide results in decreased secretion of TNF protein CTD PMID:21352583 NCBI chr20:3,626,685...3,629,303 JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:64,313,335...64,349,221 JBrowse link
vecuronium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] CTD PMID:30036686 NCBI chr 5:72,473,676...72,596,563 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] CTD PMID:30036686 NCBI chr20:9,128,056...9,184,312 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:9846649 NCBI chr 1:205,567,226...205,583,001 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:65,981,136...66,116,128 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] CTD PMID:9846649 NCBI chr17:64,696,549...65,158,622 JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9846649 NCBI chr 3:98,349,080...98,356,821 JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 8:55,401,668...55,415,165 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 3:168,136,246...168,157,839 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 8:55,417,583...55,437,027 JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] CTD PMID:31846720 NCBI chr 8:67,318,665...67,330,196 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] CTD PMID:30959089 NCBI chr 8:63,449,148...63,476,534 JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] CTD PMID:29486207 NCBI chr18:26,737,078...26,740,877 JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:3,692,367...3,709,252 JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 NCBI chr 9:99,950,972...100,200,994 JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO Vecuronium Bromide results in increased secretion of HEXB protein CTD PMID:19758318 NCBI chr 2:28,483,997...28,504,165 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression
multiple interactions		 ISO Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]		 CTD PMID:29486207 NCBI chr19:50,307,569...50,312,812 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:29486207 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:29486207 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] CTD PMID:30036686 NCBI chr 1:95,041,967...95,047,358 JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] CTD PMID:30036686 NCBI chr 3:97,614,616...97,632,053 JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr12:36,957,302...37,023,982 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] CTD PMID:31846720 NCBI chr16:72,969,824...72,974,447 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19895
        elemental molecular entity 17202
          elemental halogen 9889
            elemental bromine 154
              monoatomic bromine 147
                bromide + 147
                bromine(.) 0
                bromine(1+) 0
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